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The Social Standing Versus The Mind Standing Of Older Adults In Egypt: Cross-Sectional Analysis Of The Relationship Between Social Capital And Cognitive Functions, Shaza H. Shinaishen Dr Jun 2025

The Social Standing Versus The Mind Standing Of Older Adults In Egypt: Cross-Sectional Analysis Of The Relationship Between Social Capital And Cognitive Functions, Shaza H. Shinaishen Dr

Theses and Dissertations

Introduction: Egypt's population, much like that of other countries, is expected to age considerably over the course of the coming decades. Although biological and socioeconomic predictors of cognitive function have been studied widely, personal level social capital remains unexplored, especially in LMICs.

Purpose: This study primarily investigates the relationship between individual social capital and cognitive functioning among older adults aged 65 years and older in Egypt using the structural and cognitive components of social capital, including group membership, civic engagements, and caregiving roles.

Methods: A cross-sectional survey on 363 older individuals in different geographical and demographic segments of Egypt using …


Ways Of Living And Knowing, Reem El Hassan Mohamed Jun 2025

Ways Of Living And Knowing, Reem El Hassan Mohamed

Theses and Dissertations

After decades of sedentarization, the Muzeina tribe in South Sinai now has new generations born into sedentary lifestyles, never experiencing nomadism like their ancestors once did. This shift has impacted their knowledge system, traditionally shaped by interactions and kinship with nature. Exposure to social media is influencing younger generations' ways of living, raising the older generations’ concerns about their Bedouin identity. Despite being one of the largest tribes in South Sinai, the Muzeina are rarely represented in literature.

This ethnography explores the impact of sedentarization and contextual developments on the Muzeina's knowledge system, inherited from their ancestors. Muzeina’s relationship, and …


Finding Meaning In Loss: The Role Of Attachment Styles, Coping Strategies, And Resilience, Salma Seyam Jun 2025

Finding Meaning In Loss: The Role Of Attachment Styles, Coping Strategies, And Resilience, Salma Seyam

Theses and Dissertations

Grief is a deeply personal yet universal experience impacted by personal, social, and cultural factors. The present study examines how attachment styles, coping mechanisms, and resilience impact both grief intensity and the ability to find meaning after a loss, within an Egyptian sample. While previous studies have explored the experience of grief, few have looked at these factors within a Middle Eastern cultural context. A total of 140 bereaved Egyptians who experienced the loss of a loved one within the past three years completed standardized measures assessing grief intensity (Prolonged Grief Disorder-Revised; PG-13-R), coping strategies (Brief COPE), meaning-making (Grief and …


The Sealed Palace: How Direct Access To The Supreme Constitutional Court Can Bridge The Gaps In Constitutional Review In Egypt, Ahmed Sameh Fahmi Jun 2025

The Sealed Palace: How Direct Access To The Supreme Constitutional Court Can Bridge The Gaps In Constitutional Review In Egypt, Ahmed Sameh Fahmi

Theses and Dissertations

This thesis examines the limitations of Egypt’s current constitutional review system and argues for the introduction of a direct access mechanism to the Supreme Constitutional Court (SCC). Under Egypt’s centralized model of judicial review, individuals are restricted to indirect access through ordinary courts, which has resulted in significant procedural and substantive inefficiencies. The referral-based mechanism of judicial review of legislation has caused delays in adjudicating constitutional claims, the insulation of certain laws from review, legislative omissions, and excessive gatekeeping by lower courts. Through a comparative analysis of direct access models in Colombia, Germany, Turkey, and South Africa, the thesis identifies …


The Instrumentalization Of The Unprivileged Combatants By Western Countries Aimed To Oppress National Liberation Wars, Fares Mahmoud Def-Allah Abdelhamid Jun 2025

The Instrumentalization Of The Unprivileged Combatants By Western Countries Aimed To Oppress National Liberation Wars, Fares Mahmoud Def-Allah Abdelhamid

Theses and Dissertations

The goal of International Humanitarian Law (IHL) is purported to be the humanization of wars. Nonetheless, the atrocities committed in wars and the war criminals’ impunity suggest the failure of IHL. Notwithstanding, some voices call for reforming and developing IHL. In contrast, this thesis argues that IHL should be rejected entirely since the distinction between privileged and unprivileged combatants indicates that IHL is biased against anti-colonizers. It is biased in three senses. Firstly, IHL, particularly the distinction between privileged and unprivileged combatants, is dominated by Western rationality, which can be noticed in the domination of the civilization concept with its …


The Communal Lyric: Poetry In Devotional And Oppressed Communities, Michael N. Yacoub Jun 2025

The Communal Lyric: Poetry In Devotional And Oppressed Communities, Michael N. Yacoub

Theses and Dissertations

This thesis investigates the interaction between lyric and community; it asks what a communal lyric is, how it functions, and to what ends. In Chapter One, I compare Jonathan Culler’s performative model of lyric with the theory of Takhyīl as expounded by Arab philosopher-critics al-Farabi, Ibn Sina, and al-Qartajanni to argue that a communal lyric is a form of audience-oriented public discourse distinguished by formal features that prompt the poem’s (re-)iteration and establish an interpersonal relationship with the audience in order to influence them and make shareable value claims about the world. In Chapters Two and Three I provide close-reading …


In-Service Teachers’ Awareness And Professional Development In Egyptian Public Schools, Hanan Mohamed Metawea Jun 2025

In-Service Teachers’ Awareness And Professional Development In Egyptian Public Schools, Hanan Mohamed Metawea

Theses and Dissertations

Neuroscience is an emergent field that focuses on studying brain structure and understanding its significance in the learning process. There has been a recent movement in how to bridge the gap between neuroscience concepts and education by incorporating neuroscience principles into the teaching process. However, there have been limited studies in Egypt on how educators understand and utilize neuroscience principles in the classroom. This qualitative exploratory case study examines Egyptian teachers’ understanding of neuroscience concepts and how they apply them in their teaching practices. This case study was carried out in two government schools, including interviews with 11 teachers representing …


Paradise Lost Thrice: Exile And The Abrahamic Religions In Aciman, Werfel, And Ashour, Malak K. Hosny Jun 2025

Paradise Lost Thrice: Exile And The Abrahamic Religions In Aciman, Werfel, And Ashour, Malak K. Hosny

Theses and Dissertations

Exile is an integral part of the history of all three Abrahamic religions: Judaism, Christianity and Islam. This thesis compares between literary narratives of the exile of Jews, Christians, and Muslims. It explores the notion that having been exiled from Eden with the fall of Adam and Eve, and having each religion’s prophet’s story intrinsically tied with exile, the believers’ exile is then the third in a layered cycle of exile. Having lost the paradise, believers tend to search for earthly paradises that they attach themselves to, and then tragically lose those as well. The thesis’ three primary literary texts …


Assessing The Impact Of Digital Transformation On Regulatory Processes And Systems Compared To Traditional Paper-Based Processes At The Egyptian Drug Authority, Rania Aa Soliman Jun 2025

Assessing The Impact Of Digital Transformation On Regulatory Processes And Systems Compared To Traditional Paper-Based Processes At The Egyptian Drug Authority, Rania Aa Soliman

Theses and Dissertations

In the past several decades, the rate of scientific and technological advancements in drug development and digital fields have been extraordinary. Internet of Things and block chain technologies are currently viable in the mature cloud computing industry, these transformative examples contrast starkly with the current pharmaceutical regulatory submission, review, and approval process of the EDA. However, with the emergence of initiatives that aim to improve and expedite regulatory decision-making, there is a promising future ahead. These initiatives, if successful, will not only transform the current transactional structure but also leverage scientific and technological advances to deliver patient-centric therapies. This radical …


Stuck In The Maze: Syrian Unaccompanied Children Navigating Spheres Of Protection In Egypt, Anouk Pelletier De Chambure Jun 2025

Stuck In The Maze: Syrian Unaccompanied Children Navigating Spheres Of Protection In Egypt, Anouk Pelletier De Chambure

Theses and Dissertations

This research explores the protection of Syrian unaccompanied and separated children (UASC) in Egypt who have fled the Syrian conflict and reflects on the role of formal protection providers and informal networks of solidarity. In hopes of pushing back against the over- essentialization of UASC as vulnerable children, this research unravels the lived experiences of seven aged-out Syrian UASCs who have been living in Egypt for a few years, which reveals their authentic and original crafting of spheres of protection. This thesis aims to contribute to a more extensive and more accurate understanding of the lives and needs of Syrian …


A Tragedy Of Incommensurability: Indigenous Rights And The Limits Of Human Rights Law, Zeina Ali Jun 2025

A Tragedy Of Incommensurability: Indigenous Rights And The Limits Of Human Rights Law, Zeina Ali

Theses and Dissertations

This thesis explores the tragedy of incommensurability between indigenous rights and international human rights law. Despite the emergence of frameworks like the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP), indigenous calls for sovereignty remain fundamentally unintelligible within a liberal order structured to preserve settler-state legitimacy. Tracing the historical and theoretical evolution of indigenous advocacy, this study critiques the strategic shift from demands for self-determination to claims of cultural rights. It argues that this shift offers no real alternative: self-determination and cultural rights are functionally equivalent, as both are ultimately filtered through legal and political frameworks that cannot …


The Cellular Mechanisms Of Alzheimer's Disease Protection By The Pilra G78r Variant, Wenhan Cheng Jun 2025

The Cellular Mechanisms Of Alzheimer's Disease Protection By The Pilra G78r Variant, Wenhan Cheng

Theses and Dissertations

Microglial dysfunction is increasingly linked to Alzheimer’s Disease (AD). Immune receptors like TREM2 and CD33 play opposing roles in microglial activity. TREM2 activation triggers immunoreceptor tyrosine-based activation motif (ITAM) signaling to promote microglial activities, including amyloid-β clearance, but variants in TREM2 such as R47H that impair its function increase AD risk. In contrast, CD33 is an inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) which transmits signals that suppress microglial function. An AD-protective variant in CD33 alters CD33 activity, potentially enhancing TREM2 function. PILRA is another inhibitory immune receptor expressed by microglia that contains an ITIM. A naturally …


Awaken Your Academic Mind: The Unseen Power Of Prayer In Learning, Ryuichi Inouye Jun 2025

Awaken Your Academic Mind: The Unseen Power Of Prayer In Learning, Ryuichi Inouye

Spiritual Proficiency

Even faithful members of the Church sometimes neglect to pray when engaging in learning—something that should be of eternal importance. We invite you to use this article as a guide to overcome that weakness and experience the miracle of learning. We testify that God is pleased with such efforts and will provide wonderful support in return.


Strategic Narratives To Counter Global Threats, Jerry E. Landrum, Chase Metcalf, Michael M. Posey Jun 2025

Strategic Narratives To Counter Global Threats, Jerry E. Landrum, Chase Metcalf, Michael M. Posey

The US Army War College Quarterly: Parameters

This article argues that the current National Security Strategy lacks the necessary coherence and fidelity to mobilize collective action against the emerging Russia-China axis. It merges multiple theoretical concepts to assert that the “rules-based order” theme is insufficient for mobilizing public support. Using textual analysis of the strategy compared with publicly available polling to determine levels of popular resonance, the authors find that the “rules-based order emphasis” does not resonate. This study’s conclusions will assist practitioners as they develop an updated National Security Strategy in the new presidential administration.


When Access Is Not Enough: The Role Of Utilization Barriers In Nutrition Security And Cardiometabolic Risk, Maha Almohamad, Ruosha Li, Natalia I Heredia, Jayna M Dave, Eric E Calloway, Anjail Z Sharrief, Shreela V Sharma Jun 2025

When Access Is Not Enough: The Role Of Utilization Barriers In Nutrition Security And Cardiometabolic Risk, Maha Almohamad, Ruosha Li, Natalia I Heredia, Jayna M Dave, Eric E Calloway, Anjail Z Sharrief, Shreela V Sharma

Faculty, Staff and Student Publications

Background: Food and nutrition security are key social determinants of cardiometabolic health. While food security reflects access to sufficient food, nutrition security incorporates the quality, consistency, and usability of food that supports long-term health. However, few studies have examined how household-level barriers to food utilization shape these relationships. Objective: This study assessed whether tangible (e.g., equipment, storage) and intangible (e.g., time, knowledge) food utilization barriers modify the associations between food and nutrition security and cardiometabolic outcomes in low-income adults.

Methods: A cross-sectional survey was conducted among 486 low-income adults across five U.S. states. Participants reported household food security (USDA …


Implications Of The Mind’S Active Participation In The Formation Of Perception, Maikel Adel Samy Michael Jun 2025

Implications Of The Mind’S Active Participation In The Formation Of Perception, Maikel Adel Samy Michael

Theses and Dissertations

The mind-body problem, particularly the issue of qualia, remains a fundamental challenge in understanding the nature of the mind and its relation to the body. In this thesis I argue that the problem is epistemic, stemming from how we perceive and know ourselves as physical and mental beings. This argument will be explored through the respective of idealisms proposed by George Berkeley and Immanuel Kant. Berkeley's idealism suggests that reality is rooted in perception, offering a major steppingstone by demonstrating the major role perception plays in understanding and acquiring knowledge. Kant contributes by asserting that the "thing-in-itself" is beyond our …


Microglial Phagocytosis In Epilepsy: Mechanisms And Impact, Abhijeet S Barath, Long-Jun Wu Jun 2025

Microglial Phagocytosis In Epilepsy: Mechanisms And Impact, Abhijeet S Barath, Long-Jun Wu

The Brown Foundation: Institute of Molecular Medicine

Microglia are resident immune cells critical in maintaining brain homeostasis via their surveillance and phagocytosis function. Under disease contexts such as seizures and epilepsy, microglial phagocytic signalling is activated in response to both inflammatory and non-inflammatory cell death. This process involves a range of well-characterized 'find me' and 'eat me' signals, phagocytic receptors, and less well-characterized intracellular signalling pathways. In addition, epigenetic and transcriptional regulators orchestrate microglial responses to seizures, including the integration of phagocytic and inflammatory pathways. Interestingly, although inhibiting phagocytosis has been shown to improve neuronal survival and cognitive performance after seizures, it paradoxically increases the risk of …


Photographic Truth: Civilian Manipulation And Reality Under Stalinism, Reese Finnigan Jun 2025

Photographic Truth: Civilian Manipulation And Reality Under Stalinism, Reese Finnigan

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.


Evaluating The Chemical Composition And Sensory Attributes Of Japanese And U.S. Sake, Rahul Sen, Katie Hope, Ben Bell, Scott Robert Lafontaine Jun 2025

Evaluating The Chemical Composition And Sensory Attributes Of Japanese And U.S. Sake, Rahul Sen, Katie Hope, Ben Bell, Scott Robert Lafontaine

Food Science Faculty Publications and Presentations

Sake, a traditional rice beverage from Japan, is brewed using four key ingredients: rice, water, a koji mold, and yeast. While sake is gaining popularity in the US market, there remains a significant knowledge gap regarding the best practices for sake production and how different methods impact the chemical and sensory aspects of American sake as well as its resemblance to traditional Japanese sake. This study compared 21 sake samples from Japan and the U.S., covering grades such as ginjo, diaginjo, junmai, and nigori. Out of total 209 features, 120 were significant aromatic compounds with esters (e.g., ethyl decanoate, hexyl …


Nepaliness As Assemblage: Diasporic Belonging, Colorism, And Caste In The Associational Life Of Nepali Migrants In Florida, Shuvechha Ghimire Sharma Jun 2025

Nepaliness As Assemblage: Diasporic Belonging, Colorism, And Caste In The Associational Life Of Nepali Migrants In Florida, Shuvechha Ghimire Sharma

USF Tampa Graduate Theses and Dissertations

The research fundamentally challenges romanticized ideas of migration—shedding older inequalities, idealizing “leveling up,” and being a part of “unified diasporic communities”—and unmasks a rather uneasy, far more intricate reality: the preexisting sociocultural and political structures and identities are not shed, rather actively reproduced and rigorously, often consciously, reconfigured within the transnational diasporic spaces. As such, the research reveals that Nepali diasporic associations in Florida play a vital role in perpetuating and reshaping social inequalities and contested national identities, significantly impacting transnational dynamics. The work contends that caste hierarchies persist in structuring associational life, influencing participation and resource distribution. Concurrently, colorism …


The Effect Of Sars-Cov-2 Reinfection On Long-Term Symptoms In The Innovative Support For Patients With Sars-Cov-2 Infections Registry (Inspire), John J. Openshaw, Ji Chen, Robert Rodriguez, Michael Gottlieb, Kalyani Mccullough, Michelle Santangelo, Mandy J. Hill, Kristyn Gatling, Ahamed H. Idris, Samuel Mcdonald, Lauren E. Wisk, Jonathan Dyal, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Kelli N. O'Laughlin, Kari A. Stephens, Caitlin Malicki, Zhenqiu Lin, Erica S. Spatz, Huihui Yu, Robert A. Weinstein, Joann Elmore Jun 2025

The Effect Of Sars-Cov-2 Reinfection On Long-Term Symptoms In The Innovative Support For Patients With Sars-Cov-2 Infections Registry (Inspire), John J. Openshaw, Ji Chen, Robert Rodriguez, Michael Gottlieb, Kalyani Mccullough, Michelle Santangelo, Mandy J. Hill, Kristyn Gatling, Ahamed H. Idris, Samuel Mcdonald, Lauren E. Wisk, Jonathan Dyal, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Kelli N. O'Laughlin, Kari A. Stephens, Caitlin Malicki, Zhenqiu Lin, Erica S. Spatz, Huihui Yu, Robert A. Weinstein, Joann Elmore

Department of Emergency Medicine Faculty Papers

BACKGROUND: The clinical consequences of repeated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not clear, especially as they relate to long-term symptoms after infection. We analyzed data collected for the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE) to determine whether reinfection changes the likelihood of symptoms 3-6 months after reinfection compared with the likelihood in individuals experiencing a single infection.

METHODS: Individuals reporting a single SARS-CoV-2 infection or a single reinfection were included in this analysis. A positive SARS-CoV-2 test occurring ≥90 days after a first infection was considered a reinfection. Outcomes included severe fatigue (fatigue …


Learning To Support Science: Gender Differences In How Scientific Literacy Mediates Formal Education's Effect On Us Adults' Public Support For Science, Kevin Mark Roessger, Arie Todd Greenleaf Jun 2025

Learning To Support Science: Gender Differences In How Scientific Literacy Mediates Formal Education's Effect On Us Adults' Public Support For Science, Kevin Mark Roessger, Arie Todd Greenleaf

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

Introduction Scientific literacy is targeted by the knowledge deficit model, which predicts that increased scientific literacy improves public support for science. The model, in part, assumes formal education drives scientific knowledge, which, in turn, drives support for science. To date, though, this relationship is unclear, and research shows that, while formal education is associated with adults' public support for science, scientific literacy maintains only a small relationship with support for science, one that may differ by gender.Methods Using a conditional process analysis, we drew on 2018 General Social Survey data to examine whether scientific literacy mediates education's effects on support …


Examining Family Accommodation In Early Childhood, Allison Smith Dupre Jun 2025

Examining Family Accommodation In Early Childhood, Allison Smith Dupre

LSU Doctoral Dissertations

The relationship between parent and child anxiety is well established. One factor that may account for this relationship is family accommodation (how family members alter their behavior to alleviate child distress). Family accommodation has been studied in child anxiety for the past decade and has been linked to increased parent and child anxiety. However, little research has focused on a young sample without clinical elevations of anxiety. Acknowledging the impact of family accommodation on child anxiety, the strong link between parent anxiety and accommodation, and the importance of early intervention, this study aimed to expand the literature of family accommodation …


Examining Associations Between Sleep Variability And Treatment Outcomes In A Clinical Sample Receiving Psychotherapy Treatment For Alcohol Use Disorder, Charles A. Manzler Jun 2025

Examining Associations Between Sleep Variability And Treatment Outcomes In A Clinical Sample Receiving Psychotherapy Treatment For Alcohol Use Disorder, Charles A. Manzler

USF Tampa Graduate Theses and Dissertations

Sleep disturbances are highly prevalent among individuals with AUD. Sleep and alcohol have a bidirectional relationship such that alcohol damages sleep-promoting brain regions, and impaired sleep exacerbates cognitive and emotional deficits that can promote alcohol use. Despite the evidence that sleep improves across treatment for AUD, these improvements have had inconsistent associations with treatment outcomes. This may result from previous research focusing solely on mean values of sleep parameters rather than daily within-person variability. Sleep variability is emerging as an important correlate of physiological dysregulation and is connected to a range of negative symptoms that may promote alcohol use. The …


Do Emotion Malleability Beliefs Buffer Social Ostracism? An Experimental Investigation, Bingjie Tong Jun 2025

Do Emotion Malleability Beliefs Buffer Social Ostracism? An Experimental Investigation, Bingjie Tong

USF Tampa Graduate Theses and Dissertations

Social ostracism is linked to adverse psychological outcomes, including increased suicide risk among college students. This study examined a manipulation targeting emotion malleability beliefs and its effect on psychological outcomes after a lab-induced social ostracism task (Cyberball). Psychache, a well-established predictor for suicide risk, was examined as a potential moderator variable. College students (N = 243) were randomly assigned to either an experimental condition, which presented information stating that emotions are malleable, or a neutral control condition. Participants in the experimental condition reported a greater increase in beliefs about emotional malleability, greater use of cognitive reappraisal, and less perceived burdensomeness …


"You Need To Make The Decision You Can Live With": An Observational Study Of Anti-Abortion Centers In Tampa Bay, Anna Broich Jun 2025

"You Need To Make The Decision You Can Live With": An Observational Study Of Anti-Abortion Centers In Tampa Bay, Anna Broich

USF Tampa Graduate Theses and Dissertations

Anti-Abortion Centers (AACs) pose a grave threat to the reproductive health outcomes of Americans. Disguising themselves as licensed health clinics, AACs target vulnerable communities to prevent or delay abortion care through the spread of medical misinformation, contributing to abortion stigmatization. Situated in a state with a near-total abortion ban, this secret-shopper study aimed to understand the ways in which AACs in Tampa, Florida communicate anti-abortion rhetoric to pregnant people seeking abortions. Under the guise of people who suspect they are pregnant searching for abortion care, the main researcher and her assistants conducted the first phase of the study through 25 …


Treatment Outcomes Of Successful M1 Versus M2 Thrombectomy For Low-Aspects Stroke Patients, Huanwen Chen, Marco Colasurdo, Hidetoshi Matsukawa, Conor Cunningham, Ilko Maier, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Amir Shaban, Nitin Goyal, Shinichi Yoshimura, Hugo Cuellar, Brian Howard, Ali Alawieh, Ali Alaraj, Mohamad Ezzeldin, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Fazeel Siddiqui, Joshua Osbun, Roberto Crosa, Ramesh Grandhi, Charles Matouk, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Ergun Daglioglu, Richard Williamson, Pedro Navia, Shakeel Chowdhry, David J Altschul, Alejandro M Spiotta, Peter Kan Jun 2025

Treatment Outcomes Of Successful M1 Versus M2 Thrombectomy For Low-Aspects Stroke Patients, Huanwen Chen, Marco Colasurdo, Hidetoshi Matsukawa, Conor Cunningham, Ilko Maier, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Amir Shaban, Nitin Goyal, Shinichi Yoshimura, Hugo Cuellar, Brian Howard, Ali Alawieh, Ali Alaraj, Mohamad Ezzeldin, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Fazeel Siddiqui, Joshua Osbun, Roberto Crosa, Ramesh Grandhi, Charles Matouk, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Ergun Daglioglu, Richard Williamson, Pedro Navia, Shakeel Chowdhry, David J Altschul, Alejandro M Spiotta, Peter Kan

Faculty, Staff and Students Publications

Background

The effectiveness of endovascular thrombectomy (EVT) for low Alberta Stroke Program Early CT score (ASPECTS) stroke patients with occlusion of the second segment of the middle cerebral artery (M2) is unclear.

Methods

This was a multicenter retrospective study. Patients with M1 or M2 occlusions and low ASPECTS (< 6) who underwent successful EVT (modified treatment in cerebral ischemia score of 2b or higher) were included. Primary outcome was futile EVT reperfusion (defined as 90-day modified Rankin scale of 5 or 6). Other outcomes of interest include acceptable outcomes (modified Rankin scale of 3 or less) and intracranial hemorrhage (ICH), and all-cause 90-day mortality. Outcomes for M1 patients were compared to M2 patients with multivariable logistic regression models accounting for potential confounders.

Results

173 patients with M1 or M2 occlusions and low ASPECTS (< 6) who underwent successful EVT were identified. After multivariable adjustments, M2 patients had significantly higher odds of futile reperfusion (OR 5.48 [95%CI 1.91 to 15.7], p = 0.002), lower odds of acceptable outcomes (OR 0.33 [95%CI 0.12 to 0.89], p = 0.028), and higher odds of all-cause mortality (OR 4.90 [95%CI 1.65 to 14.5], p = 0.004). These findings suggest that EVT's efficacy for low-ASPECTS stroke patients may be diminished for patients with M2 occlusions. M2 occlusion was not significantly associated with ICH.

Conclusions

Among low-ASEPCTS stroke patients who underwent successful EVT, those with M2 occlusions had significantly higher odds of poor outcome compared to those with M1 occlusions.


Heightened Risk: Childhood Trauma And Anticipatory Grief Exacerbate The Impact Of Loneliness On Depressive Symptoms And Lps-Stimulated Cytokines In Dementia Caregivers, Kelly N. Brice, Jensine Paoletti-Hatcher, E Lydia Wu-Chung, Vincent D. Lai, Daniel L. Argueta, Michelle A. Chen, Itee Mahant, Bryan T. Denny, Charles Green, Luis D. Medina, Multiple Additional Authors Jun 2025

Heightened Risk: Childhood Trauma And Anticipatory Grief Exacerbate The Impact Of Loneliness On Depressive Symptoms And Lps-Stimulated Cytokines In Dementia Caregivers, Kelly N. Brice, Jensine Paoletti-Hatcher, E Lydia Wu-Chung, Vincent D. Lai, Daniel L. Argueta, Michelle A. Chen, Itee Mahant, Bryan T. Denny, Charles Green, Luis D. Medina, Multiple Additional Authors

Psychology Faculty Publications and Presentations

Dementia spousal caregivers are at a disproportionate risk for adverse mental and physical health outcomes. Loneliness is associated with depressive symptoms and proinflammatory cytokine production among caregivers. Additionally, childhood trauma, anticipatory grief, and poor sleep quality are all associated with enhanced stress reactivity. This study used a cross-sectional design to investigate whether loneliness is associated with proinflammatory cytokine production and depressive symptoms in caregivers, and whether these relationships are strongest among caregivers who report high levels of childhood trauma, high amounts of anticipatory grief, or poor sleep quality. A sample of 111 dementia spousal caregivers provided blood samples and completed …


Psychological Interventions Added To Standard Care Improve Pain And Function Outcomes In Knee Osteoarthritis: A Systematic Review And Meta‐Analysis, Tim Phelps, Jonathan Gilby, Joanne Hosking, Jonathon Gill Jun 2025

Psychological Interventions Added To Standard Care Improve Pain And Function Outcomes In Knee Osteoarthritis: A Systematic Review And Meta‐Analysis, Tim Phelps, Jonathan Gilby, Joanne Hosking, Jonathon Gill

School of Health Professions

Objective: Knee osteoarthritis is a primary cause of disability across the world and current standard care fails to address all biopsychosocial contributions to pain. The current review aims to evaluate randomised controlled trials examining the effect of adding cognitive behavioural therapy or pain coping skills training to standard care on pain and function outcomes for individuals with knee osteoarthritis. Data sources: Systematic searches were conducted of CINAHL, EMBASE (OVID), Medline (EBSCO) and PsycINFO databases until July 2024 with no date restrictions. Methods: This systematic review followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Risk of bias …


Integrating Endocannabinoid Signaling, Cck Interneurons, And Hippocampal Circuit Dynamics In Behaving Animals, Shreya Malhotra, Florian Donneger, Jordan S Farrell, Barna Dudok, Attila Losonczy, Ivan Soltesz Jun 2025

Integrating Endocannabinoid Signaling, Cck Interneurons, And Hippocampal Circuit Dynamics In Behaving Animals, Shreya Malhotra, Florian Donneger, Jordan S Farrell, Barna Dudok, Attila Losonczy, Ivan Soltesz

Faculty, Staff and Students Publications

The brain's endocannabinoid signaling system modulates a diverse range of physiological phenomena and is also involved in various psychiatric and neurological disorders. The basic components of the molecular machinery underlying endocannabinoid-mediated synaptic signaling have been known for decades. However, limitations associated with the short-lived nature of endocannabinoid lipid signals had made it challenging to determine the spatiotemporal specificity and dynamics of endocannabinoid signaling in vivo. Here, we discuss how novel technologies have recently enabled unprecedented insights into endocannabinoid signaling taking place at specific synapses in behaving animals. In this review, we primarily focus on cannabinoid-sensitive inhibition in the hippocampus in …