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A Descriptive Bibliometric Study Of Cera Publication Dissemination, Authorship, And Citation Rates., Bryce A Ringwald, Jennifer L Middleton Jul 2025

A Descriptive Bibliometric Study Of Cera Publication Dissemination, Authorship, And Citation Rates., Bryce A Ringwald, Jennifer L Middleton

Medical Education Articles

BACKGROUND AND OBJECTIVES: Barriers to performing family medicine research include funding, infrastructure, and mentorship shortages. The Council of Academic Family Medicine Educational Research Alliance (CERA) was created in 2011 to address these issues. This study explores the scope and impact of CERA-related publications in family medicine.

METHODS: We performed a descriptive bibliometric study of CERA-related publications from 2011 to 2023. Articles were sourced from Medline (PubMed), SCOPUS, and the CERA website. Data analysis focused on publication type, authors, CERA survey type, and citation rates.

RESULTS: From a total of 231 articles retrieved via initial searches and 166 from the CERA …


Statewide Injunction: State Judicial Power And Meaningful Remedies, Constance C. Van Kley Jul 2025

Statewide Injunction: State Judicial Power And Meaningful Remedies, Constance C. Van Kley

Faculty Law Review Articles

As federal courts increasingly limit the scope of constitutional remedies, state courts have begun issuing statewide injunctions that extend protections beyond individual litigants. This article examines the doctrinal foundations and implications of such injunctions, arguing that they represent a legitimate exercise of state judicial power. By analyzing historical practices, procedural norms, and recent case law, the author contends that statewide injunctions can serve as essential tools for enforcing civil rights and ensuring meaningful relief. The piece calls for a reevaluation of remedial doctrines to better accommodate the evolving role of state courts in safeguarding constitutional guarantees.


Chronic Pain Is Associated With Greater Brain Entropy In The Prefrontal Cortex, Gianpaolo Del Mauro, Yiran Li, Jiaao Yu, Peter Kochunov, Landrew Samuel Sevel, Jeff Boissoneault, Shuo Chen, Ze Wang Jul 2025

Chronic Pain Is Associated With Greater Brain Entropy In The Prefrontal Cortex, Gianpaolo Del Mauro, Yiran Li, Jiaao Yu, Peter Kochunov, Landrew Samuel Sevel, Jeff Boissoneault, Shuo Chen, Ze Wang

Faculty, Staff and Student Publications

Chronic pain is a debilitating clinical condition and a severe public health issue that demands to be addressed. Neuroimaging-based techniques have been widely adopted to investigate the neural underpinnings of chronic pain. Despite the efforts the complex nature of pain experience as well as the heterogeneity of chronic pain have made the identification of neuroimaging-based biomarkers extremely challenging. In this study, resting-state fMRI-based brain entropy, a measure reflecting the "irregularity" of brain activity, was adopted as a biomarker of chronic pain by comparing individuals with chronic pain and healthy controls in a sample of middle-to-old-age participants (n > 30,000) drawn from …


Factors Associated With Self-Report Symptom Screening Adherence In Pediatric Cancer Patients, L Lee Dupuis, Allison A King, Lisa M Klesges, Et Al. Jul 2025

Factors Associated With Self-Report Symptom Screening Adherence In Pediatric Cancer Patients, L Lee Dupuis, Allison A King, Lisa M Klesges, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Objective was to describe the association between baseline characteristics and the number of Symptom Screening in Pediatrics Tool (SSPedi) assessments completed over an 8-week period.

METHODS: This was a sub-analysis of a cluster randomized controlled trial among 10 sites that were randomized to the intervention group. Participants were English- or Spanish-speaking pediatric patients 8-18 years of age newly diagnosed with cancer. Participants were prompted to complete SSPedi three times weekly for 8 weeks. The outcome was the number of SSPedi assessments completed during the 8-week period. Factors associated with the number of assessments were determined using mixed effects Poisson …


Geopolymer Clsm With Off-Specification Fly Ash And Bottom Ash: A Sustainable Approach To Hazardous Waste Utilization, Alexis K. Vandomelen, Ahmed A. Gheni, Eslam Gomaa, Mohamed A. Elgawady Jul 2025

Geopolymer Clsm With Off-Specification Fly Ash And Bottom Ash: A Sustainable Approach To Hazardous Waste Utilization, Alexis K. Vandomelen, Ahmed A. Gheni, Eslam Gomaa, Mohamed A. Elgawady

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Conventional controlled low-strength material (CLSM) is a self-consolidating cementitious material with high flowability and low strength, traditionally composed of cement, sand, and water. This study explores the sustainable utilization of off-specification fly ash (OSFA) and bottom ash (BA), classified as industrial by-products with potential environmental hazards, to develop eco-friendly geopolymer CLSM as an alternative to conventional CLSM. Sodium hydroxide (NaOH) was used as an alkali activator to stabilize and solidify both two-part (liquid NaOH) and one-part (solid NaOH pellets) geopolymer CLSM mixtures. These mixtures were evaluated based on flowability (ASTM D6103-17) and compressive strength (< 300 psi per ACI Committee 229 guidelines for excavatability). A cost analysis was also conducted. The results demonstrated that incorporating OSFA as a cement replacement increased water demand by 15% to meet flowability requirements, while BA substitution for sand led to segregation challenges requiring mixture adjustments. For two-part mixtures, higher carbon content in OSFA necessitated an increased water-to-fly ash ratio. All self-consolidating mixtures exhibited 1-day compressive strengths ranging from 5 psi (0.03 MPa) to 87 psi (0.6 MPa). One-part mixtures showed a 1% to 34% reduction in 7-day compressive strength compared to two-part mixtures, improving excavatability. Increasing the BA-to-OSFA ratio from 1:1 to 3:1 reduced water demand due to lower surface area but increased the NaOH/OSFA ratio. This study highlights the potential of geopolymer CLSM to reduce costs by up to 94% at current NaOH prices (USD 6 per cubic yard) while repurposing hazardous industrial by-products, offering a cost-efficient, sustainable, and environmentally responsible solution for CLSM production.


Towards Accountability: A Primer On The Space Debris Problem And An Overview Of The Legal Issues Surrounding It, William Schonberg Jul 2025

Towards Accountability: A Primer On The Space Debris Problem And An Overview Of The Legal Issues Surrounding It, William Schonberg

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Since 1957, the near-Earth population of trackable space objects has grown in number to over 36,000. Of these 36,000+ trackable objects now in low Earth orbit, just a few thousand are working spacecraft. The rest are Earth-orbiting objects which are no longer operational and are considered to be space junk. Because this junk can no longer receive maneuvering commands from its Earth-based owners, the survivability of other spacecraft traveling through or operating in Earth orbit can be jeopardized by the impacts of any number of pieces of this space junk, whose origins can usually be traced back to defunct satellites. …


Ftir Characterization Of Asphalt Sara Fractions In Response To Rubber Modification, Mohyeldin Ragab, Eslam Deef-Allah, Magdy Abdelrahman Jul 2025

Ftir Characterization Of Asphalt Sara Fractions In Response To Rubber Modification, Mohyeldin Ragab, Eslam Deef-Allah, Magdy Abdelrahman

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Asphalt–rubber binders (A-RBs) have a long and deep history of use; however, little is known regarding the interrelated chemical behaviors and miscibility of rubber with the asphalt fractions [saturates, aromatics, resins, and asphaltenes (SARA)]. This study comprehensively attempted to address this knowledge deficiency by employing Fourier transform infrared spectroscopy (FTIR) to investigate the chemical evolution of A-RBs. A-RB interacted at 190 °C and 3000 min−1 for 8 h was deemed to have the optimal rheological performance. FTIR of the liquid fractions of A-RB 190–3000 showed a prominent chemical shift in the SARA fractions, with new peaks that showed rubber …


Investigating The Thixotropy Of Fresh Struvite Cement-Based Composite: Insights On Mechanisms Of The Pastes’ Thixotropic Behavior, Ugochukwu Ewuzie, Abdulkareem O. Yusuf, Damilola Daramola, Monday Uchenna Okoronkwo Jul 2025

Investigating The Thixotropy Of Fresh Struvite Cement-Based Composite: Insights On Mechanisms Of The Pastes’ Thixotropic Behavior, Ugochukwu Ewuzie, Abdulkareem O. Yusuf, Damilola Daramola, Monday Uchenna Okoronkwo

Chemical and Biochemical Engineering Faculty Research & Creative Works

Struvite (ST) recovered during wastewater treatment has been sparsely applied in cement-based composites. This study systematically evaluated the thixotropic behavior of cement-struvite (CST) pastes, a mix of 5–20 % ST by mass of cement, and proposed the interaction mechanisms leading to the pastes' thixotropy. The hysteresis loop area was used to establish the pastes' thixotropy and investigate its relationship with increased ST content, temperature, and yield stress. In the thixotropic behavior model used, the equilibrium shear stress was employed to examine the CST pastes' irreversible change; the characteristic time of deflocculation was used to study the flocs destruction process; and …


Navigating Child Oral Health In Western Australia: A Caregiver's Perspective, Lesley Andrew, Elizabeth Wenden, Mohamed Estai, Ruth Wallace Jul 2025

Navigating Child Oral Health In Western Australia: A Caregiver's Perspective, Lesley Andrew, Elizabeth Wenden, Mohamed Estai, Ruth Wallace

Research outputs 2022 to 2026

Background: Early childhood caries (ECC) is the most common chronic health condition among Australian preschool-aged children. Untreated, ECC can affect children's physical and emotional health and future social opportunities. ECC is largely preventable through primary caregivers' correct understanding of oral health promoting diets, oral hygiene practices and dental service engagement. The study aim is to explore Western Australian (WA) primary caregivers' child oral health knowledge, experience and practices. The Fisher-Owens socioecological model of child oral health was applied across the study to structure and interpret the findings across the complex, interactive sociocultural influences on child oral health. Methods: The mixed-methods …


Social Service Inclusion Of Immigrants Through The Lens Of Human Rights In Australia, Obed Adonteng-Kissi, Matthew Mabefam, Nnaemeka Meribe, Frank Darkwa Baffour, Elizabeth Archibong Jul 2025

Social Service Inclusion Of Immigrants Through The Lens Of Human Rights In Australia, Obed Adonteng-Kissi, Matthew Mabefam, Nnaemeka Meribe, Frank Darkwa Baffour, Elizabeth Archibong

Research outputs 2022 to 2026

Motivation: A human-centred approach to social service design is necessary to encourage social service inclusion and to offer an avenue for social service action in Australia and globally. Purpose: The purpose of this article is to ascertain the extent to which social service providers design their services to include immigrants. Approach and methods: We draw on literature exploring social service inclusion and the perspectives of 27 social workers and immigrant service users. Semi-structured interviews were conducted with eight social workers and 19 immigrants who were purposefully selected from Brisbane, Townsville, Melbourne and Sydney. We applied the capability theoretical approach of …


Asthma Exacerbation: Dexamethasone Vs. Prednisolone Dosing, Children's Mercy Kansas City Jul 2025

Asthma Exacerbation: Dexamethasone Vs. Prednisolone Dosing, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.


Cell-Free Protein Synthesis Reactor Formats: A Brief History And Analysis, Dallin M. Chipman, Anna C. Woolley, Davu N. Chau, William A. Lance, Joseph P. Talley, Tyler P. Green, Benjamin C. Robbins, Bradley Charles Bundy Jul 2025

Cell-Free Protein Synthesis Reactor Formats: A Brief History And Analysis, Dallin M. Chipman, Anna C. Woolley, Davu N. Chau, William A. Lance, Joseph P. Talley, Tyler P. Green, Benjamin C. Robbins, Bradley Charles Bundy

Faculty Publications

Cell-free protein synthesis (CFPS) has transformed protein production capabilities by eliminating cellular constraints, enabling the rapid expression of difficult-to-produce proteins in an open, customizable environment. As CFPS applications expand from fundamental research to industrial production, therapeutic manufacturing, and point-of-care diagnostics, the diverse array of reactor formats has become increasingly important yet challenging to navigate. This review examines the evolution and characteristics of thirteen major CFPS reactor formats, from traditional batch systems to advanced platforms. The historical development of CFPS reactors from the 1960s to present day is presented. Additionally, for each format, operational principles, advantages, limitations, and notable applications are …


A Systematic Review Of The Internet Of Things And Artificial Intelligence Applications In Milk Quality Monitoring And Analysis, Rahul Mhapsekar, Deirdre Kilbane, Steven Davy, Lizy Abraham, Mark Fenelon, Norah O'Shea Jul 2025

A Systematic Review Of The Internet Of Things And Artificial Intelligence Applications In Milk Quality Monitoring And Analysis, Rahul Mhapsekar, Deirdre Kilbane, Steven Davy, Lizy Abraham, Mark Fenelon, Norah O'Shea

Research Outputs: 2025-Present

Background: Milk quality analysis (MQA) is critical for ensuring high-quality dairy production and enhancing the productivity of dairy processing plants. The integration of Internet of Things (IoT) and artificial intelligence (AI) can revolutionise MQA by enabling automated, real-time detection and monitoring of key parameters (i.e. composition, adulterants, indicators of microbial quality), reducing human error and improving decision-making in the dairy supply chain. Aim(s): This systematic review aimed to evaluate the application of IoT and AI in MQA over the past decade, focussing on three critical areas: composition monitoring, adulteration detection and indicators of microbial quality. Methods: A systematic analysis of …


Volume 34, Number 2, Summer/Fall 2025, Office Of Communications, Illinois Wesleyan University Jul 2025

Volume 34, Number 2, Summer/Fall 2025, Office Of Communications, Illinois Wesleyan University

Illinois Wesleyan University Magazine, 2018-present

VOLUME 34 | NUMBER 2 | Summer/Fall 2025

ON OUR COVER:

The Illinois Wesleyan University archives, housed on the fourth floor of The Ames Library, holds many artifacts of IWU history, including the original university charter and a gold medal awarded to John Marden, clas of 1909, for his breakthrough work in atomic science and engineering.

18 175 Years of Illinois Wesleyan University. Celebrate IWU's history with a timeline of the last 175 years of our community's milestones.

26 Alumni Award Winners. Meet our Award Winners John Camardella '03, Natalie Lalagos '12, and Carol Willis '68.


Unbounded Multi-Hop Proxy Re-Encryption With Hra Security: An Lwe-Based Optimization, Xiaohan Wan, Yang Wang, Haiyang Xue, Mingqiang Wang Jul 2025

Unbounded Multi-Hop Proxy Re-Encryption With Hra Security: An Lwe-Based Optimization, Xiaohan Wan, Yang Wang, Haiyang Xue, Mingqiang Wang

Research Collection School Of Computing and Information Systems

Proxy re-encryption (PRE) schemes enable a semi-honest proxy to transform a ciphertext of one user i to another user j while preserving the privacy of the underlying message. Multi-hop PRE schemes allow a legal ciphertext to undergo multiple transformations, but for lattice-based multi-hop PREs, the number of transformations is typically bounded due to the increase of error terms. Recently, Zhao et al. (ESORICS 2024) introduced a lattice-based unbounded multi-hop (homomorphic) PRE scheme that supports an unbounded number of hops. Nevertheless, their scheme only achieves the selective CPA security. In contrast, Fuchsbauer et al. (PKC 2019) proposed a generic framework for …


An Incentive Mechanism For Privacy Preserved Data Trading With Verifiable Data Disturbance, Man Zhang, Xinghua Li, Bin Luo, Yanbing Ren, Yinbin Miao, Ximeng Liu, Robert H. Deng Jul 2025

An Incentive Mechanism For Privacy Preserved Data Trading With Verifiable Data Disturbance, Man Zhang, Xinghua Li, Bin Luo, Yanbing Ren, Yinbin Miao, Ximeng Liu, Robert H. Deng

Research Collection School Of Computing and Information Systems

To motivate data owners’ (DOs’) trading willingness, the existing incentive mechanisms allow DOs to independently disturb data following data consumer's (DC’s) availability requirement. However, they cannot motivate DOs’ honest disturbance, which is attributed to DOs’ independent disturbance without any supervision. Thus, we implement an incentive mechanism for privacy preserved data trading with verifiable data disturbance where an honest-but-curious disturbance generator (DG) is additionally introduced to supervise DOs’ local disturbance and assist disturbance verification between DOs and DC. Specifically, DG generates the disturbance strategies and secretly distributes to DOs following private information retrieval, guaranteeing DOs's local disturbance's privacy and verifiability with …


Collaboration With Dynamic Open Ad Hoc Team Via Team State Modelling, Jing Sun, Cong Zhang, Zhiguang Cao Jul 2025

Collaboration With Dynamic Open Ad Hoc Team Via Team State Modelling, Jing Sun, Cong Zhang, Zhiguang Cao

Research Collection School Of Computing and Information Systems

Open ad hoc teamwork presents the challenging problem of designing an autonomous agent that can rapidly adapt to collaborate with teammates without prior coordination in an open environment. Existing methods primarily rely on fixed, predefined teammate types, overlooking the fact that teammates may change dynamically. To address this limitation, we propose a novel reinforcement learning approach, the Open Online Teammate Adaptation Framework (Open-OTAF), which enables a controlled agent to collaborate with dynamic teammates in open ad hoc environments. To achieve this, the controlled agent employs a dual teamwork situation inference model to capture the current teamwork state, facilitating decision-making under …


Ts-Diff: Two-Stage Diffusion Model For Low-Light Raw Image Enhancement, Yi Li, Zhiyuan Zhang, Jiangnan Xia, Jianghan Cheng, Qilong Wu, Junwei Li Jul 2025

Ts-Diff: Two-Stage Diffusion Model For Low-Light Raw Image Enhancement, Yi Li, Zhiyuan Zhang, Jiangnan Xia, Jianghan Cheng, Qilong Wu, Junwei Li

Research Collection School Of Computing and Information Systems

This paper presents a novel Two-Stage Diffusion Model (TS-Diff) for enhancing extremely low-light RAW images. In the pre-training stage, TS-Diff synthesizes noisy images by constructing multiple virtual cameras based on a noise space. Camera Feature Integration (CFI) modules are then designed to enable the model to learn generalizable features across diverse virtual cameras. During the aligning stage, CFIs are averaged to create a target-specific CFIT, which is fine-tuned using a small amount of real RAW data to adapt to the noise characteristics of specific cameras. A structural reparameterization technique further simplifies CFIT for efficient deployment. To address color shifts during …


Rustmap: Towards Project-Scale C-To-Rust Migration Via Program Analysis And Llm, Xuemeng Cai, Jiakun Liu, Xiping Huang, Yijun Yu, Haitao Wu, Chunmiao Li, Bo Wang, Imam Nur Bani Yusuf, Lingxiao Jiang Jul 2025

Rustmap: Towards Project-Scale C-To-Rust Migration Via Program Analysis And Llm, Xuemeng Cai, Jiakun Liu, Xiping Huang, Yijun Yu, Haitao Wu, Chunmiao Li, Bo Wang, Imam Nur Bani Yusuf, Lingxiao Jiang

Research Collection School Of Computing and Information Systems

Migrating existing C programs into Rust is increasingly desired, as Rust offers superior memory safety while maintaining C’s high performance. Existing automated translation tools, such as C2Rust, may rely too much on syntactic, template-based translation and generate unsafe Rust code that is hard for human developers to read, maintain, or even compile. More semantic-aware translation that produces safer, idiomatic, and runnable Rust code is much needed. This paper introduces a novel dependency-guided and large language model (LLM)-based C-to-Rust translation approach, RustMap, based on three key ideas: (1) Utilize LLM’s capabilities to produce idiomatic Rust code from given small pieces of …


Quantum Technologies In Decentralisation, Paul Robert Griffin, Rudy Raymond, Tsuyoshi Idé Jul 2025

Quantum Technologies In Decentralisation, Paul Robert Griffin, Rudy Raymond, Tsuyoshi Idé

Research Collection School Of Computing and Information Systems

Quantum technologies, rooted in the manipulation of quantum information, are revolutionizing computing and networking domains. Their impact on blockchains and decentralized systems is twofold. While much attention has been given to the potential of quantum computing to attack blockchains, these advanced technologies also offer avenues for strengthening and optimizing them. This chapter delves into the intricacies of quantum technologies, from the foundational concepts of qubits, quantum gates, and quantum networks to their implications for blockchains. We explore both the vulnerabilities of blockchains in a quantum-dominant era and the promising solutions quantum technologies provide, culminating in a use case examining their …


The Employment Situation Of Veterans: July 2025, Institute For Veterans And Military Families At Syracuse University Jul 2025

The Employment Situation Of Veterans: July 2025, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

In July 2025, veteran unemployment dropped significantly to 3.0 percent, down from 3.7 percent in June, reflecting stronger labor outcomes compared to nonveterans. Post‑9/11 veteran unemployment also declined to 3.1 percent. Younger veterans experienced major improvements, with unemployment among those aged 18–24 falling from 6.2 percent to 1.8 percent. Most veteran age groups saw declines, except ages 35–44 and 55–64, which saw slight increases. Male veteran unemployment decreased to 2.7 percent, while female veteran unemployment held steady at 4.4 percent. Overall, veterans continued to maintain lower unemployment rates than nonveterans.


Gallium-Containing Bioactive Glasses: Their Influence On Ion Release And The Bioactivity Of Resulting Glass Polyalkenoate Cements, Lana Margaret Placek, Danielle Lee Perry, Mark Robert Towler, Anthony William Wren Jul 2025

Gallium-Containing Bioactive Glasses: Their Influence On Ion Release And The Bioactivity Of Resulting Glass Polyalkenoate Cements, Lana Margaret Placek, Danielle Lee Perry, Mark Robert Towler, Anthony William Wren

Chemical and Biochemical Engineering Faculty Research & Creative Works

A series of glasses (0.48SiO2 − [0.40-x]ZnO − 0.12CaO-xGa2O3, x = 0, 0.8, 0.16) was developed to formulate a series of Ga-containing glass polyalkenoate cements (GPCs). The solubility of GPCs was tested using DI water, and it was found that the sample containing the highest mol% of Ga, LGa-2, had the most Ga ion release. The GPCs were incubated in SBF, and SEM/EDS analysis revealed that the at% of P increased, while the at% of Si decreased, highlighting the CaP precipitation on the GPC surface. The at% of Ga also decreased, reinforcing the Ga release from the GPC. Cellular testing …


In Reply: Most Elderly Patients With Subclinical Hypothyroidism Do Not Need To Be Treated, Risheng Xu, Nicola Abate, Nalini Ram, Kristina Little Jul 2025

In Reply: Most Elderly Patients With Subclinical Hypothyroidism Do Not Need To Be Treated, Risheng Xu, Nicola Abate, Nalini Ram, Kristina Little

Faculty, Staff and Students Publications

No abstract provided.


Anemia In Inflammatory Bowel Disease: Practice Patterns And Clinical Outcomes In A Large National Veterans Cohort, Jared A Sninsky, Carolyn Brooks, Shubhada Sansgiry, Richa Shukla, Stalin Subramanian, Jason K Hou Jul 2025

Anemia In Inflammatory Bowel Disease: Practice Patterns And Clinical Outcomes In A Large National Veterans Cohort, Jared A Sninsky, Carolyn Brooks, Shubhada Sansgiry, Richa Shukla, Stalin Subramanian, Jason K Hou

Faculty, Staff and Students Publications

Background: Anemia is a common complication of inflammatory bowel disease (IBD), impacting patient quality of life and clinical outcomes. This study examines anemia management practices and clinical outcomes in a national cohort of veterans with IBD.

Methods: A retrospective cohort study of 89 687 veterans with IBD from 2000 to 2017 was conducted using Veterans Health Administration data. We assessed anemia screening, iron store assessments, and iron therapy. Primary outcomes included anemia resolution within 12 months. Secondary outcomes included IBD-related hospitalizations, steroid use, and surgery within five years. Multivariate logistic regression models assessed associations between patient characteristics and clinical outcomes. …


Dichotomous Roles Of Acbd3 In Nsclc Growth And Metastasis, Xiaochao Tan, Chao Wu, Priyam Banerjee, Shike Wang, Derrick L Cardin, Yuting Xu, Chad J Creighton, William K Russell Jul 2025

Dichotomous Roles Of Acbd3 In Nsclc Growth And Metastasis, Xiaochao Tan, Chao Wu, Priyam Banerjee, Shike Wang, Derrick L Cardin, Yuting Xu, Chad J Creighton, William K Russell

Faculty, Staff and Students Publications

Lung cancer continues to be the leading cause of cancer-related deaths globally. Unraveling the regulators behind lung cancer growth and its metastatic spread, along with understanding the underlying mechanisms, is crucial for developing novel and effective therapeutic strategies. While much research has focused on identifying potential oncogenes or tumor suppressors, the roles of certain genes can vary depending on the context and may even exhibit contradictory effects. In this study, we demonstrate that acyl-CoA binding domain containing 3 (ACBD3), a Golgi resident protein, promotes primary lung cancer growth by recruiting phosphatidylinositol (PI)-4-kinase IIIβ (PI4KB) to the Golgi, thereby enhancing oncogenic …


Cytokine Release Syndrome And Neurotoxicity Following Cd19 Car-T In B-Cell Lymphoma, Roni Shouval, Christopher Strouse, Soyoung Kim, Temitope Oloyede, Sairah Ahmed, Farrukh T Awan, Danny Luan, Veronika Bachanova, Talha Badar, Merav Bar, Pere Barba, Amer M Beitinjaneh, Amanda Cashen, Bhagirathbhai Dholaria, Mahmoud Elsawy, Siddhartha Ganguly, Praveen Ramakrishnan Geethakumari, Uri Greenbaum, Hamza Hashmi, Laquisa C Hill, Michael D Jain, Tania Jain, Partow Kebriaei, Adam S Kittai, Frederick L Locke, Premal D Lulla, Elena Mead, Joseph P Mcguirk, Alberto Mussetti, Taiga Nishihori, Amanda L Olson, Martina Pennisi, Miguel-Angel Perales, Peter A Riedell, Wael Saber, Abu-Sayeef Mirza, Margarida Magalhaes-Silverman, Elizabeth J Shpall, Mohamed Sorror, Kitsada Wudhikarn, Cameron J Turtle, Amy Moskop, Marcelo C Pasquini Jul 2025

Cytokine Release Syndrome And Neurotoxicity Following Cd19 Car-T In B-Cell Lymphoma, Roni Shouval, Christopher Strouse, Soyoung Kim, Temitope Oloyede, Sairah Ahmed, Farrukh T Awan, Danny Luan, Veronika Bachanova, Talha Badar, Merav Bar, Pere Barba, Amer M Beitinjaneh, Amanda Cashen, Bhagirathbhai Dholaria, Mahmoud Elsawy, Siddhartha Ganguly, Praveen Ramakrishnan Geethakumari, Uri Greenbaum, Hamza Hashmi, Laquisa C Hill, Michael D Jain, Tania Jain, Partow Kebriaei, Adam S Kittai, Frederick L Locke, Premal D Lulla, Elena Mead, Joseph P Mcguirk, Alberto Mussetti, Taiga Nishihori, Amanda L Olson, Martina Pennisi, Miguel-Angel Perales, Peter A Riedell, Wael Saber, Abu-Sayeef Mirza, Margarida Magalhaes-Silverman, Elizabeth J Shpall, Mohamed Sorror, Kitsada Wudhikarn, Cameron J Turtle, Amy Moskop, Marcelo C Pasquini

Faculty, Staff and Students Publications

Chimeric antigen receptor T cell (CAR-T) therapy is an effective treatment for relapsed-refractory large B-cell lymphoma (LBCL). However, toxicities, particularly cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), remain significant concerns. Analyze temporal trends, risk factors, and associations between these toxicities and their severity. In this registry study by the Center for International Blood and Marrow Transplant Research, we studied CRS and ICANS in 1916 LBCL patients treated with commercial CAR-T therapies (axicabtagene ciloleucel 74.9%, tisagenlecleucel 25.1%) between 2018 and 2020. Outcomes include development of CRS/ICANS, timing and severity according to ASTC grading, overall survival (OS). Risk …


Fibroblast-Restricted Inflammasome Activation Promotes Atrial Fibrillation And Heart Failure With Diastolic Dysfunction, Luge Li, Cristian Coarfa, Yue Yuan, Issam Abu-Taha, Xiaolei Wang, Jia Song, Yuying Zeng, Xiaohui Chen, Amrit Koirala, Sandra L Grimm, Markus Kamler, Lisa K Mcclendon, Michelle Tallquist, Stanley Nattel, Dobromir Dobrev, Na Li Jul 2025

Fibroblast-Restricted Inflammasome Activation Promotes Atrial Fibrillation And Heart Failure With Diastolic Dysfunction, Luge Li, Cristian Coarfa, Yue Yuan, Issam Abu-Taha, Xiaolei Wang, Jia Song, Yuying Zeng, Xiaohui Chen, Amrit Koirala, Sandra L Grimm, Markus Kamler, Lisa K Mcclendon, Michelle Tallquist, Stanley Nattel, Dobromir Dobrev, Na Li

Faculty, Staff and Students Publications

Atrial fibrillation (AF) often coexists with heart failure, both involving inflammatory signaling and cardiac fibroblasts. To understand the role of fibroblast NLR family pyrin domain containing 3 (NLRP3) inflammasome in cardiac function, we found that NLRP3 was up-regulated in atrial fibroblasts from AF patients. Fibroblast-specific activation of NLRP3 in mice induced AF-promoting atrial myopathy and heart failure with diastolic dysfunction, accompanied by increased fibrosis, and reduced conduction velocity. Knockdown of NLRP3 prevented the AF-promoting atrial substrate and cardiomyopathy in the context of NLRP3 activation in fibroblasts. We identify the fibroblast NLRP3 inflammasome as a key pathway governing the promotion of …


Celebrity Politics: Construction And Validation Of A Scale To Measure The Political Influence Of Celebrities, Azmat Rasul, Donghee Shin Jul 2025

Celebrity Politics: Construction And Validation Of A Scale To Measure The Political Influence Of Celebrities, Azmat Rasul, Donghee Shin

All Works

This study develops and validates the Political Influence of Celebrities Scale (PICS), designed to assess how entertainment celebrities influence young adults’ political attitudes and behaviors. Drawing on survey data collected from 498 university students in the United States, we applied exploratory and confirmatory factor analysis to test the scale’s structure and psychometric validity. The results support a three-factor model consisting of general attitudes toward celebrities, enjoyment of celebrity-centered political content, and behavioral outcomes such as political discussion and participation. Each subscale demonstrated strong internal reliability (Cronbach’s α ≥ .79). The PICS provides a theoretically grounded and empirically supported measure to …


Reporting Abcd1 Variants As Actionable Secondary Findings On Exome And Genome Sequencing, Carlos A Dominguez Gonzalez, Nancy B Spinner, Rebecca C Ahrens-Nicklas, Lisa R Young, Laura A Voss, Sara L Reichert, Daniel J Gallo, Julie S Cohen, Joshua L Bonkowsky, Stephanie R Keller, Mariko L Bennett, Amy M Pizzino, Meghan Swantkowski, Kaley Arnold, Jamie L Fraser, Felicity J Emerson, Kelly Miettunen, Ali Fatemi, Keith P Van Haren, Laura Adang, Amy Waldman, Lisa Emrick, Florian Eichler, Adeline Vanderver Jul 2025

Reporting Abcd1 Variants As Actionable Secondary Findings On Exome And Genome Sequencing, Carlos A Dominguez Gonzalez, Nancy B Spinner, Rebecca C Ahrens-Nicklas, Lisa R Young, Laura A Voss, Sara L Reichert, Daniel J Gallo, Julie S Cohen, Joshua L Bonkowsky, Stephanie R Keller, Mariko L Bennett, Amy M Pizzino, Meghan Swantkowski, Kaley Arnold, Jamie L Fraser, Felicity J Emerson, Kelly Miettunen, Ali Fatemi, Keith P Van Haren, Laura Adang, Amy Waldman, Lisa Emrick, Florian Eichler, Adeline Vanderver

Faculty, Staff and Students Publications

No abstract provided.


Implementing A Stakeholder-Informed Approach For Standardized Collection Of Sexual Orientation And Gender Identity Data: Lessons Learned At A Matrix Comprehensive Cancer Center, Susan L Parker, Montserrat Ayala-Ramirez, Jane R Montealegre, Michael E Scheurer Jul 2025

Implementing A Stakeholder-Informed Approach For Standardized Collection Of Sexual Orientation And Gender Identity Data: Lessons Learned At A Matrix Comprehensive Cancer Center, Susan L Parker, Montserrat Ayala-Ramirez, Jane R Montealegre, Michael E Scheurer

Faculty, Staff and Students Publications

This brief report describes takeaways from the implementation of sexual orientation and gender identity (SOGI) data collection within a matrix comprehensive cancer center. Implementation of standardized and parsimonious SOGI data collection practices is a strategy recommended to improve our understanding of the cancer experiences among sexual and gender minority (SGM) populations. However, interventions are rarely sustained in routine practice without an organized program to support their implementation. We used a stakeholder-engaged approach to integrate a SOGI questionnaire in the electronic health record (EHR) at Dan L Duncan Comprehensive Cancer Center (DLDCCC)-affiliated adult oncology clinics and evaluate its feasibility, acceptability, and …