Digital Commons Network^™

The Shorthorn: September 18, 1970

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

The Shorthorn: September 4, 1970

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

Evaluating The Toxicity Of Electronic Cigarette Aerosols For Firsthand And Secondhand Exposure Under Different Device Operating Conditions, Kashala Fabrice Kapiamba, Hsin Yin Chuang, Weixing Hao, Ta Chun Lin, Lung Chi Chen, Yue-Wern Huang, Yang Wang

Biological Sciences Faculty Research & Creative Works

The rapid proliferation of electronic cigarettes (ECs) has raised significant concerns about their potential health effects on both users and bystanders. This study systematically investigates the impact of EC aerosol exposure on human alveolar epithelial cells (A549), considering variations in device parameters, nicotine concentration, and exposure type. Using a gravity-based air–liquid interface exposure system, we assessed cytotoxicity and epithelial barrier integrity by measuring cell viability and transepithelial electrical resistance (TEER). Our results indicate that EC aerosol exposure significantly reduces cell viability and disrupts monolayer integrity in a dose- and device-dependent manner. Notably, VUSE (pod-type) exposure led to a 16% decrease …

2025-2026 Ursinus College Course Catalogue, Office Of The Registrar

Ursinus College Catalogues, 1869-Present

A digital copy of the 2025-2026 Ursinus College Catalog. It contains details of the curriculum, departmental requirements and courses of instruction as well as the Open Questions core requirements, experiential learning and the Common Intellectual Experience (CIE). Academic policies, special opportunities and scholarships, off-campus programs and graduation requirements are also outlined.

The Current - Volume 36 Issue 1, Nova Southeastern University

Student Newspapers

No abstract provided.

Addressing Psychosocial Barriers To Participation In People Experiencing Homelessness: An Occupational Therapy Workshop, Preston E. Bender

Student Capstone Papers

This capstone project addressed the critical gap in occupational therapy education and practice regarding the psychosocial needs of people experiencing homelessness. Despite the occupational therapy profession’s emphasis on holistic, person-centered care, many occupational therapy practitioners and occupational therapy students report feeling a lack of self-efficacy and preparedness to navigate the complex psychological, social, and systemic barriers that hinder occupational participation among this population. This capstone project aimed to address the perceived unpreparedness among clinicians through the creation of an 8-hour interactive educational workshop. The workshop is grounded in the Model of Human Occupation and informed by the Bridging the Transition …

Stephanie Murrin V. Commissioner Of Internal Revenue

2025 Decisions

Tax Court

Two Decapod Crustaceans, Panopeus Herbstii And Petrolisthes Armatus, Stabilize Their Gaze Using Achromatic Visual Cues, But Not The Angle Of Linearly Polarized Light, M. Janakis, S. Guirges, A. C. Grant, I. Paris, E. F. Lopresti, Daniel Isaac Speiser

Faculty Publications

No abstract provided.

Mechanisms Of Ssdna Gap Resection In Brca1-Proficient And -Deficient Cells, Isabelle Seppa

Arts & Sciences Graduate Student Theses and Dissertations

Single-stranded (ss) DNA gaps are potentially genome-destabilizing structures that require prompt repair (or filling) to prevent DNA breakage and genome instability. We previously showed that gap repair is defective in cancer cells with deficiencies in the breast cancer susceptibility gene BRCA1. These findings explain why ssDNA gaps accumulate in BRCA1-deficient cells in response to therapies that target DNA, such as platinum-based compounds, or therapies that inhibit specific repair pathways, such as PARP inhibitors (PARPi). We also discovered that gap repair can be restored in BRCA1-deficient cells by inhibiting MRE11 nuclease activity, indicating that nuclease processing plays a central role in …

Design And Evaluation Of An Electromagnetic Band Gap Structure For Self-Interference Reduction In Mmwave Full-Duplex Systems, Adewale Kehinde Oladeinde

Dissertations and Theses

Full-duplex (FD) wireless is a new technology that allows a device to transmit and receive at the same time and on the same frequency band. It has the potential to double the capacity and spectral efficiency of a wireless link compared to the family of conventional half-duplex wireless systems. The key challenge in implementing FD wireless communication is self-interference (SI): a node's transmitting signal generates significant interference to its receiver. Several previous studies have demonstrated the potential to reduce SI and develop FD radios; however, these studies are mostly limited to sub-6 GHz systems. Previous and on-going research explored various …

Florida Fish And Wildlife Conservation Commission Comment Tool For Proposed Changes To Trapping Regulations, Amy Donley, Jacquelyn Reiss

Institute for Social and Behavioral Science (ISBS)

No abstract provided.

Essay, The Mighty Mangrove, Carol A. Mickett

Creekshed: Ekphrastic Writing with the Archives

An ekphrastic reflection on mangroves in Tampa Bay.

Registered Nurses' Autism Knowledge And Preparedness To Care For Autistic Patients, Bronte Elisa Weissman

Theses and Dissertations

Autistic individuals frequently report negative experiences during healthcare interactions and numerous provider-level barriers to accessing quality care, including stereotyping, perceived lack of autism knowledge, challenges with communication, and insufficient accommodations. Reports of healthcare providers’ experiences caring for autistic patients in the U.S. have largely come from physicians, who endorse inadequate training, resources, and practical guidelines. Although patients spend far more time with nurses than other healthcare providers, registered nurses (RNs)’ perspectives on caring for autistic patients in the U.S. are largely unknown and autism-focused trainings for nurses are minimal. In the current study, a survey was nationally disseminated to a …

Understanding Loss To Follow-Up: The Role Of Social Determinants Of Health In Infants Referred After A Positive Newborn Screening – A Quantitative Analysis, Betsy Graham-Moeller Graham-Moeller

Walden Dissertations and Doctoral Studies

Newborn screening (NBS) is a vital U.S. public health initiative that identifies medical conditions shortly after birth. Patients with positive screenings are referred for medical follow-up or evaluation. However, many patients do not receive the recommended long-term follow-up, posing concerns for healthcare providers and public health professionals working to ensure timely treatment and care continuity. Based on the Social Determinants of Health framework, this quantitative, retrospective cohort study aimed to examine demographic and clinical factors associated with follow-up adherence among 691 infants identified through NBS in Colorado and Wyoming. The purpose of the study was to determine whether race, ethnicity, …

Adapting Publishing Principles And Best Practices For Repository-Hosted Journals: Sustainable Ideas For Enhancing Local Open Access Publishing, Andrea A. Wirth

Library Faculty Research

This poster addresses the question: How can librarians and administrators working with repository-hosted journal editors incorporate best practices into hosted journals without taking on the role of publisher and without overextending themselves?

The "Principles of Transparency and Best Practice in Scholarly Publishing" (COPE, DOAJ, OASPA, WAME, 2022) provides foundational guidance for journal publishing. The guidelines cover a robust suite of topics such as authorship, peer review, funding sources, author cost transparency, and licensing and copyright. Publishers with staff who support a suite of journals (whether 10 or 1000) may be able to evaluate and adopt such guidance relatively quickly and …

Anti-Tumor Activity Of Camptothecin Analog Conjugate Of An Rspo4-Based Peptibody Targeting Lgr4/5/6 In Preclinical Models Of Colorectal Cancer, Yukimatsu Toh, Ling Wu, Jianghua Tu, Zhengdong Liang, Adela M Aldana, Jake J Wen, Li Li, Sheng Pan, Julie H Rowe, Martha E Hensel, Carolyn L Hodo, Rick A Finch, Kendra S Carmon, Qingyun J Liu

The Brown Foundation: Institute of Molecular Medicine

Background: Antibody-drug conjugates (ADCs) are a significant advancement in targeted cancer therapy, but none are approved for colorectal cancer (CRC). LGR4/5/6, highly expressed in most CRCs, are promising targets. While LGR5-targeting ADCs show strong anti-tumor effects, their efficacy is limited by LGR5 loss in some CRC cells. RSPO4, a natural ligand for LGR4/5/6, binds all three receptors with high affinity. This research develops RSPO4-based peptibody drug-conjugates (PDCs) to simultaneously target LGR4/5/6, offering a novel therapeutic approach for CRC.

Methods: LGR4/5/6 expression in CRCs was analysed using RNA-seq datasets and Western blot. Peptibody binding affinities were measured, conjugated to camptothecin analog, …

A Potential New Sea Surface Temperature Proxy Based On Isomeric Highly Branched Isoprenoid Lipid Biomarkers: Ez25, Simon T. Belt, Lukas Smik, Katrine Husum, Jochen Knies

School of Geography, Earth and Environmental Sciences

Two tri-unsaturated and isomeric (E/Z) highly branched isoprenoid (HBI) diatom lipid biomarkers were quantified in 228 water column samples collected from the English Channel, West Svalbard (Arctic), the Scotia Sea (Southern Ocean) and East Antarctica. We found that the relative amounts of the two HBIs correlate well with water temperatures taken at the time of sampling. Based on these findings and some other HBI data reported previously, we suggest that the proportion of the HBI E-isomer (termed EZ25) may serve as a new proxy for palaeo sea surface temperatures, including in the polar regions. Next steps will involve determination of …

Simulated Emergency Room Sign-Outs: What They Tell Us About Diagnostic Accuracy And Opportunities For Improvement, Roni Matin, Brent R King, Amit M Mehta, Susan H Fenton, Nathan R Hoot, David J Robinson, Charles L Maddow, Amy Franklin

Faculty, Staff and Student Publications

Objective: Emergency department (ED) sign-outs provide continuity of care for patients at shift changes. However, these periods have been associated with communication breakdowns and medical errors. We explored information factors (stage-of-the-case and the explicitness of the sign-out narrative) to determine their impact on clinicians' diagnostic accuracy and confidence.

Methods: Clinicians from 2 academic ED sites reviewed patient vignettes sign-out narratives (N=69). Using a within-subjects experiment, the explicitness of the sign-out information (i.e., broad statement about labs versus stating each test) and the patient's stage in the diagnostic process (e.g., labs pending, treatment occurring, etc.) at the time of sign-out varied. …

The Impact Of Mental Health Courts On Public Attitudes Held Toward Justice-Involved Individuals With Mental Illness, Maeve Porter

Student Theses

Prior research has established that mental health court programs play an important role in reducing recidivism and mental health symptoms of defendants. However, there is a lack of understanding of the stigma that justice-involved individuals may encounter upon release from mental health court into the community, and the extent to which the general public is aware of mental health court programs. The present study sought to address public perceptions regarding mental health courts, their efficacy, and their participants based on the awareness and availability of these specialized courts in two similar states (New York and New Jersey), one in which …

Development Of Turbulence Models For Prediction Of Hypersonic Flows Using Compressibility Corrections And Uncertainty Quantification With Emphasis On The Wray-Agarwal Model, Aidan Robert Murphy

McKelvey School of Engineering Graduate Student Theses & Dissertations

Accurate prediction of high-speed compressible turbulent flows remains one of the most significant challenges in Computational Fluid Dynamics (CFD), especially in the realm of hypersonic vehicle design. These flow regimes involve significant aerodynamic heating and shock-wave boundary layer interactions (SBLI) which remain a significant challenge for the current CFD prediction capabilities. While Direct Numerical Simulation (DNS) and Large-Eddy Simulation (LES) provide high-fidelity solutions, their computational demands limit their usability, making the Reynolds-Averaged Navier-Stokes (RANS) equations an efficient alternative for many industrial aerodynamic applications. Traditional RANS techniques, while computationally efficient, often provide limited accuracy in high-speed flows due to the presence …

Smartphone Attachment In Emerging Adults : Impacts On Mental Health Through Basic Psychological Needs, Jialin Xiao

Lingnan Theses (MPhil & PhD)

In the digital era, smartphones have become integral to daily life, fulfilling various emotional needs. Mirroring human attachment, past studies have found people can develop three types of attachment to smartphone: secure (comfortable, dependable connection), anxious (intense emotional reliance with separation anxiety) and avoidant (preference for independence from one’ s phone) attachment. However, little is known about how these types of smartphone attachment relate to mental health over time. Moreover, the mechanism underlying the relationship between smartphone attachment and mental health is unknown. To fill these gaps, based on the attachment theory, this study examined the longitudinal associations between smartphone …

Transmission Patterns That Reduce Population Size Without Increasing Disease Prevalence: Masting And Chronic Wasting Disease In White-Tailed Deer, Virginia Kanzinger, Karen C. Abbott

Faculty Scholarship

How individuals use space and, thus, the rate and the nature of their interactions with others are shaped by their environment. Exogenous changes that alter aggregation patterns, such as resource pulses, can therefore have a significant impact on seemingly unrelated processes like disease spread. White-tailed deer (Odocoileus virginianus) aggregate in oak forests during mast events, and chronic wasting disease (CWD) transmission patterns vary with deer density, so we hypothesize a link between the masting cycle and CWD dynamics. We investigate various possible effects of masting on deer, including shifts to more frequency-dependent CWD transmission due to aggregation, as well as …

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Theoretical Study On Electronic And Optoelectronic Properties Of Some C^N^N- And C^C^C-Chelated Iridium(Iii) Complexes For Oleds, Ayhan Üngördü

Turkish Journal of Chemistry

The electronic and optoelectronic properties of 8 C∧N∧N- and C∧C∧C-chelated Ir(III) complexes were investigated using density functional theory at the Becke-style 3-parameter Lee-Yang-Par and triple zeta plus polarization level. Based on reorganization energy calculations, complex 7 was identified as a promising ambipolar material, while complexes 1 and 2 had efficient hole transport properties. Complex 8 had low ionization potential and is therefore a strong candidate for hole transport applications. Complex 4 had high electron affinity and therefore has potential as an effective electron acceptor material. Photophysical analysis showed that all complexes had phosphorescent properties, with complexes 5 and 6 showing …

The Implications Of Insecure Use Of Fonts Against Pdf Documents And Web Pages, Junjie Xiong, Mingkui Wei, Xiao Han, Zhuo Lu, Yao Liu

Computer Science Faculty Research & Creative Works

This paper identifies the importance of the safe use of fonts in web and document security. We find multiple attack surfaces that can be exploited by an adversary using malicious fonts. We conduct a comprehensive evaluation of Portable Document Format (PDF) documents collected from the real world to investigate how an attacker can bypass PDF signatures. We further evaluate the potential security threats that an attacker can bring to web-based emails. Our study shows that various security issues may be caused by the inappropriate use of fonts, which are nevertheless overlooked in the past years. As such, guidelines promoting the …

Extended Survival With Pancreatic Carcinosarcoma: A Case Report And Literature Review, Tian Xiao, Claire Browne, Morgan Black, Celia Marginean, Elena Tsvetkova

Faculty, Staff and Students Publications

Pancreatic carcinosarcoma is a rare and aggressive malignancy that can mimic pancreatic adenocarcinomas in presentation but often has different disease biology and different responses to conventional treatment for pancreatic adenocarcinoma. Case reports have documented a 5-year overall survival of approximately 13% only if the disease is caught at an earlier stage and is amenable to multi-modality treatment, including surgery, chemotherapy, and radiation. In the advanced stage, treatments do not often provide benefit, and patients may decline rapidly. There are currently no studies demonstrating survival benefits with chemotherapy in patients with metastatic carcinosarcoma, owing to both the rarity and the often …

Improving Automated Deep Phenotyping Through Large Language Models Using Retrieval-Augmented Generation, Brandon T Garcia, Lauren Westerfield, Priya Yelemali, Nikhita Gogate, E Andres Rivera-Munoz, Haowei Du, Moez Dawood, Angad Jolly, James R Lupski, Jennifer E Posey

Faculty, Staff and Students Publications

Background: Diagnosing rare genetic disorders relies on precise phenotypic and genotypic analysis, with the Human Phenotype Ontology (HPO) providing a standardized language for capturing clinical phenotypes. Rule-based HPO extraction tools use concept recognition to automatically identify phenotypes, but they often struggle with incomplete phenotype assignment, requiring significant manual review. While large language models (LLMs) hold promise for more context-driven phenotype extraction, they are prone to errors and "hallucinations," making them less reliable without further refinement. We present RAG-HPO, a Python-based tool that leverages retrieval-augmented generation (RAG) to elevate accuracy of HPO term assignment by LLM. This approach bypasses the limitations …

Mechano-Signal Transduction Pathways Of The Diaphragmatic Muscle And Role Of Cytoskeleton, Junaith S Mohamed, Patricia S Pardo, Aladin M Boriek

Faculty, Staff and Students Publications

Mechanotransduction, also referred to as mechano-signal transduction, is a biophysical process wherein cells perceive and respond to mechanical stimuli by converting them into biochemical signals that initiate specific cellular responses. This mechanism is fundamental to the development and growth, and proper functioning of mechanically active tissues, such as the diaphragm-a respiratory muscle vital for breathing in mammals. In vivo, the diaphragm is subjected to transdiaphragmatic pressure, and therefore, its muscle fibers are subjected to mechanical forces not only in the direction of the muscle fibers but also in the direction transverse to the fibers. Previous research conducted in our laboratory …

High-Grade Glioma With Pleomorphic And Pseudopapillary Features: A Single-Institution Series Of Three Cases, Eric A Goethe, Rasha Alfattal, Subhiksha Srinivasan, Pushan Dasgupta, Vinay Puduvalli, Shiao-Pei Weathers, Leomar Y Ballester, Jeffrey S Weinberg, Sujit Prabhu, Sherise D Ferguson, Maria A Gubbiotti

Faculty, Staff and Students Publications

Introduction: Modern molecular diagnostic techniques such as DNA methylation profiling are leading to the reclassification of several central nervous system malignancies and discovery of novel diagnostic entities, such as high-grade glioma with pleomorphic and pseudopapillary features (HPAP).

Methods: We performed a retrospective chart review of all patients with HPAP confirmed with methylation profiling at a single institution between 2023 and 2025. Demographic, radiographic, surgical, and outcome data were collected.

Results: Three patients were identified: two females and one male with a mean age of 49.7 years (range 25-62). No patients had a prior cancer history. One patient had an incidentally …

Meta-Analytic Insights On Cover Crop Weed Suppression In The Midsouthern United States, Amar S. Godar, Jason K. Nprsworthy

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Herbicide resistance poses an escalating challenge to successful weed management in contemporary cropping systems, prompting growing interest in integrated strategies to reduce reliance on herbicides. Although cover cropping has long been recognized for its potential to suppress weeds, it has recently gained renewed attention as a weed management tool and for its ability to help producers achieve broader goals of soil health and environmental sustainability. Although research on its efficacy in the midsouthern United States has accumulated, a meta-analytic synthesis has been lacking. This meta-analysis synthesized 746 effect sizes from 27 peer-reviewed studies (selected based on explicit reporting of weed …