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Inhibition Of Mcl-1 And Mek Overcomes Mek Inhibitor Resistance In Triple-Negative And Inflammatory Breast Cancers, Mohd Mughees, Moises Tacam, Alex W Tan, Mary Kathryn Pitner, Lakesla R Iles, Xiaoding Hu, Emilly S Villodre, Bisrat G Debeb, Takahiro Kogawa, Bora Lim, Rachel M Layman, Wendy A Woodward, Naoto T Ueno, Debu Tripathy, Savitri Krishnamurthy, Yuan Qi, Lajos Pusztai, Jian Wang, Varsha Gandhi, Geoffrey Bartholomeusz, Chandra Bartholomeusz Sep 2025

Inhibition Of Mcl-1 And Mek Overcomes Mek Inhibitor Resistance In Triple-Negative And Inflammatory Breast Cancers, Mohd Mughees, Moises Tacam, Alex W Tan, Mary Kathryn Pitner, Lakesla R Iles, Xiaoding Hu, Emilly S Villodre, Bisrat G Debeb, Takahiro Kogawa, Bora Lim, Rachel M Layman, Wendy A Woodward, Naoto T Ueno, Debu Tripathy, Savitri Krishnamurthy, Yuan Qi, Lajos Pusztai, Jian Wang, Varsha Gandhi, Geoffrey Bartholomeusz, Chandra Bartholomeusz

Faculty, Staff and Student Publications

The MAPK pathway can drive resistance in highly aggressive breast cancers. Our previous work showed that the MEK inhibitor (MEKi) AZD6244 (selumetinib) prevented lung metastasis in a breast cancer xenograft model. In clinical studies, MEKis as single agents have had only modest activity against solid tumors due to the onset of resistance. Using synthetic lethality siRNA screening, we identified myeloid cell leukemia-1 (MCL-1) as a potential contributor to AZD6244 resistance. We hypothesized that MCL-1 promotes MEKi resistance in highly aggressive breast cancers and that MCL-1 inhibition overcomes AZD6244 resistance. We established two AZD6244-resistant cell lines: MDA-MB-231-R (triple-negative breast cancer) and …


Trends In Radiation Use From 2004 To 2020 Among Adolescents And Young Adults With Hodgkin Lymphoma, Kelsey L Corrigan, Amy M Berkman, Jillian Gunther, Clark R Andersen, Susan Wu, Amber Gibson, Branko Cuglievan, Miriam B Garcia, Gohar Manzar, Penny Fang, Brian De, Sairah Ahmed, Cesar Nunez, Michelle A T Hildebrandt, David C Mccall, Susan K Parsons, Michael E Roth Sep 2025

Trends In Radiation Use From 2004 To 2020 Among Adolescents And Young Adults With Hodgkin Lymphoma, Kelsey L Corrigan, Amy M Berkman, Jillian Gunther, Clark R Andersen, Susan Wu, Amber Gibson, Branko Cuglievan, Miriam B Garcia, Gohar Manzar, Penny Fang, Brian De, Sairah Ahmed, Cesar Nunez, Michelle A T Hildebrandt, David C Mccall, Susan K Parsons, Michael E Roth

Faculty, Staff and Student Publications

Background: Hodgkin lymphoma has excellent survival rates in adolescents and young adults (AYA, diagnosed between ages 15 and 39 years). However, survivors are at risk of treatment-related late effects. Whereas radiotherapy (RT) de-escalation/omission has emerged as an approach to minimize late effects, no prior studies have evaluated RT use over time in AYAs with Hodgkin lymphoma.

Methods: Using the National Cancer Database, we identified 40,717 AYAs diagnosed with Hodgkin lymphoma between 2004 and 2020. Differences in sociodemographic and clinical variables were assessed using a two-sample two-sided t test or χ2 test. RT use was summarized per year by frequency with …


Functional Connectivity Predicting Transdiagnostic Treatment Outcomes In Internalizing Psychopathologies, Kai Zhang, Heide Klumpp, Jagan Jimmy, K Luan Phan, Mohammed R Milad, Zhenfu Wen Sep 2025

Functional Connectivity Predicting Transdiagnostic Treatment Outcomes In Internalizing Psychopathologies, Kai Zhang, Heide Klumpp, Jagan Jimmy, K Luan Phan, Mohammed R Milad, Zhenfu Wen

Faculty, Staff and Student Publications

Importance: Predicting treatment outcomes for internalizing psychopathologies (IPs), such as depression and anxiety, holds promise for advancing precision medicine. The extent to which whole-brain functional connectivity (FC) can predict treatment responses for patients with IPs across different therapeutic modalities remains unclear.

Objective: To examine whether pretreatment FC patterns predict multidimensional treatment outcomes in patients with IPs and whether predictive performance generalizes across diagnoses and treatment modalities.

Design, setting, and participants: This prognostic study analyzed baseline neuroimaging and clinical data from patients with IPs enrolled in 1 of 2 randomized clinical trials (conducted from December 2013 to February 2018 and September …


Identification Of An Rsph4a Founder Variant And Newborn Screening For Primary Ciliary Dyskinesia, Wilfredo De Jesús-Rojas, Katherine P Guerra-Torres, Alondra J Rosado-Ayala, Edwin L Acevedo-Soto, Marcos J Ramos-Benitez, Ricardo A Mosquera Sep 2025

Identification Of An Rsph4a Founder Variant And Newborn Screening For Primary Ciliary Dyskinesia, Wilfredo De Jesús-Rojas, Katherine P Guerra-Torres, Alondra J Rosado-Ayala, Edwin L Acevedo-Soto, Marcos J Ramos-Benitez, Ricardo A Mosquera

Faculty, Staff and Student Publications

This cross-sectional study estimates the prevalence of an RSPH4A variant identified in Puerto Rico in an effort to evaluate the feasibility of targeted newborn screening for primary ciliary dyskinesia (PCD).


Usage And Behavioral Data Of Consumers Using Hair Dye Products Containing 2-Methoxymethyl-P-Phenylenediamine, Monika Kock, Carsten Goebel, Lidia Mihailescu, Maike Seib, Agnieszka Malesa, Anthony Gaspari, Brunhilde Blömeke Sep 2025

Usage And Behavioral Data Of Consumers Using Hair Dye Products Containing 2-Methoxymethyl-P-Phenylenediamine, Monika Kock, Carsten Goebel, Lidia Mihailescu, Maike Seib, Agnieszka Malesa, Anthony Gaspari, Brunhilde Blömeke

Department of Dermatology and Cutaneous Biology Faculty Papers

The potent sensitizer PPD is considered a key sensitizer in hair dye contact allergy. Modification of its molecular structure to 2-methoxymethyl-p-phenylenediamine (ME-PPD) reduces its skin sensitizing potency. We investigated the usage, behavior, and tolerance profile of ME-PPD-containing professional hair color products in a specifically tailored proactive market surveillance program in hairdresser salons across 5 countries. Hairdressers completed record cards for their clients, which were evaluated at the end of the program. 497 individuals received in total 2461 hair color treatments with ME-PPD-containing hair color. Feedback on compatibility was provided for 194 individuals: 6 individuals reported intolerance reactions, which were assessed …


Psma-1-Dota Potentially For Effective Targeted Radioligand Therapy Of Prostate Cancer, Xinning Wang, Olga Sergeeva, Maxim Sergeev, Lifang Zhang, Zoey Lockwood, Zhenghong Lee, James P. Basilion Sep 2025

Psma-1-Dota Potentially For Effective Targeted Radioligand Therapy Of Prostate Cancer, Xinning Wang, Olga Sergeeva, Maxim Sergeev, Lifang Zhang, Zoey Lockwood, Zhenghong Lee, James P. Basilion

Faculty Scholarship

Purpose: While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the α-emitting RLT often results in severe salivary gland toxicity, limiting its use. Various strategies to mitigate this side effect have been attempted with limited success. Accordingly, this study introduced a new PSMA-targeting ligand with more favorable binding characteristics than the existing ligands. Procedures: The binding affinity of PSMA-1-DOTA to PSMA was compared with that of PSMA-11 and PSMA I&T. Comparison of uptake in the salivary glands, kidneys and PC3pip tumor cells in the xenograft mouse models between [⁶⁸Ga]Ga-PSMA-1-DOTA, [⁶⁸Ga]Ga-PSMA-11 and [⁶⁸Ga]Ga-PSMA I&T was conducted …


Magnetic Nanoparticles Tethered With Zn–Dpa For The Removal Of Bacteria From Red Blood Cell Suspension, Tochukwu P. Okonkwo, Rajendra P. Gautam, Jacob B. Limburg, Breckin L. Forstrom, Bowen J. Houser, Aaron Rappleyea, Tyler P. Green, Joseph P. Talley, Alexander D. Daum, Stacey J. Smith, Karine Chesnel, William G. Pitt, Roger G. Harrison Sep 2025

Magnetic Nanoparticles Tethered With Zn–Dpa For The Removal Of Bacteria From Red Blood Cell Suspension, Tochukwu P. Okonkwo, Rajendra P. Gautam, Jacob B. Limburg, Breckin L. Forstrom, Bowen J. Houser, Aaron Rappleyea, Tyler P. Green, Joseph P. Talley, Alexander D. Daum, Stacey J. Smith, Karine Chesnel, William G. Pitt, Roger G. Harrison

Faculty Publications

Bacterial infections continue to drive the need for more effective and rapid methods for bacterial analysis. To address this, magnetic nanoparticles (MNPs) have emerged as promising tools, especially when their surfaces are modified with bacteria binders. The bis-zinc–dipicolylamine (Zn–DPA) complex is known for its broad affinity to bacteria. We have synthesized MNPs via a thermal decomposition method, encapsulated them in silica, modified their surface with Zn–DPA, and tested their ability to remove bacteria. The MNPs retain their superparamagnetic properties and crystallite structure after being encapsulated. The MNPs coated with silica and Zn–DPA effectively bind and remove both Gram-positive and Gram-negative …


What Is Worthy Of Inclusion? An Assessment Of The Utility Of Content Selection Strategies At Institutions Of Higher Learning In Zimbabwe, Darlington Mutanda Sep 2025

What Is Worthy Of Inclusion? An Assessment Of The Utility Of Content Selection Strategies At Institutions Of Higher Learning In Zimbabwe, Darlington Mutanda

Irish Journal of Academic Practice

The selection of content for university curricula is of the utmost importance, especially at universities where lecturers have choice in content selection. By contrast, in many jurisdictions, state school systems for primary and secondary schools have syllabi that must be followed to the letter. University teachers/lecturers can choose what to teach, and the selection of content can be based on several factors such as convenience (choosing to teach what one is comfortable with), expertise, research interests, ideology, by accident, or even what one was taught previously despite the dynamic change of knowledge. This means that the student can be impacted …


Commensal Colonization Of Candida Albicans In The Mouse Gastrointestinal Tract Is Mediated Via Expression Of Candidalysin And Adhesins, Kelsey E Mauk, Pedro Miramón, Michael C Lorenz, Léa Lortal, Julian R Naglik, Bernhard Hube, Lynn Bimler, Farrah Kheradmand, David B Corry Sep 2025

Commensal Colonization Of Candida Albicans In The Mouse Gastrointestinal Tract Is Mediated Via Expression Of Candidalysin And Adhesins, Kelsey E Mauk, Pedro Miramón, Michael C Lorenz, Léa Lortal, Julian R Naglik, Bernhard Hube, Lynn Bimler, Farrah Kheradmand, David B Corry

Faculty, Staff and Students Publications

The ubiquitous fungal pathogen Candida albicans has the potential to either asymptomatically colonize the gastrointestinal (GI) tract or become an invasive pathogen through mechanisms that remain incompletely understood. Here we explored the fungal, host, and environmental factors that influence the ability of C. albicans to colonize the mouse GI tract using a representative clinical strain, CLCA10. After a single gavage challenge (5 × 106 CFU C. albicans), specific pathogen-free (SPF) mice remained colonized with C. albicans strain CLCA10, but not other Candida species, for at least 58 days with the fungus confined largely to the gut luminal …


Encapsulation Of Disease-Causing And Commensal Mitis Group Non-Pneumococcal Streptococci, Daniel M Musher, Mathias Müsken, M John Hicks, Lesley Mcgee, Bernard Beall Sep 2025

Encapsulation Of Disease-Causing And Commensal Mitis Group Non-Pneumococcal Streptococci, Daniel M Musher, Mathias Müsken, M John Hicks, Lesley Mcgee, Bernard Beall

Faculty, Staff and Students Publications

Background: Mitis group non-pneumococcal streptococci (MGNPS), specifically Streptococcus mitis, Streptococcus infantis and Streptococcus oralis, have recently been shown to cause pneumonia and/or bacteremia. These organisms often have capsular (cps) operons resembling those in pneumococci, and some express cps-generated polysaccharides that antigenically cross-react with pneumococcal capsular serotypes. But, to date, a series of MGNPS isolates has not been studied by electron microscopy (EM) for the presence of a capsule.

Methods: We studied 21 MGNPS; 11 were isolated from sputum and determined to have caused pneumonia, 3 were isolated from blood, and 7 were commensal isolates cultured …


Genome-Wide Insights Into The Genes And Pathways Shaping Human Foveal Development: Redefining The Genetic Landscape Of Foveal Hypoplasia, Callum Hunt, Ha-Jun Yoon, Alvin Lirio, Kayesha Coley, Jun Wang, Nick Shrine, Jianming Shao, Gail D E Maconachie, Zhanhan Tu, Jonathan H Zippin, Pirro G Hysi, Christopher J Hammond, Omar A Mahroo, Mariya Moosajee, Michel Michaelides, Andrew R Webster, Ala Moshiri, Rui Chen, Martin D Tobin, Chiara Batini, Mervyn G Thomas, Uk Biobank Eye And Vision Consortium Sep 2025

Genome-Wide Insights Into The Genes And Pathways Shaping Human Foveal Development: Redefining The Genetic Landscape Of Foveal Hypoplasia, Callum Hunt, Ha-Jun Yoon, Alvin Lirio, Kayesha Coley, Jun Wang, Nick Shrine, Jianming Shao, Gail D E Maconachie, Zhanhan Tu, Jonathan H Zippin, Pirro G Hysi, Christopher J Hammond, Omar A Mahroo, Mariya Moosajee, Michel Michaelides, Andrew R Webster, Ala Moshiri, Rui Chen, Martin D Tobin, Chiara Batini, Mervyn G Thomas, Uk Biobank Eye And Vision Consortium

Faculty, Staff and Students Publications

Purpose: To define the genetic architecture of foveal morphology and explore its relevance to foveal hypoplasia (FH), a hallmark of developmental macular disorders.

Methods: We applied deep-learning algorithms to quantify foveal pit depth from central optical coherence tomography (OCT) B-scans in 61,269 UK Biobank participants. A genome-wide association study (GWAS) was conducted using REGENIE, adjusting for age, sex, height, and ancestry. Rare coding variants (frequency < 1%) were analyzed in an exome-wide rare-variant association study (RVAS). Candidate genes were prioritized using integrative mapping; pathway, cross-ancestry, and genetic-correlation analyses were exploratory.

Results: GWAS identified 126 sentinel variants, including 47 novel associations. Integrative mapping prioritized 129 putative causal genes, with 64 not previously implicated in foveal biology. Enriched pathways included retinoic acid metabolism (e.g., CYP26A1), photoreceptor differentiation …


Barriers And Facilitators To Surgical Trainee Psychological Safety, Jennifer H Chen, Alyssa A Pradarelli, Julie Evans, Niki Matusko, Norah N Naughton, Roy Phitayakorn, John T Mullen, Lily Chang, Melissa Johnson, Thavam Thambi-Pillai, Jon Ryckman, Melissa Alvarez-Downing, Nell Maloney Patel, Sebastiano Cassaro, Felicia Ivascu, David T Hughes, Gurjit Sandhu Sep 2025

Barriers And Facilitators To Surgical Trainee Psychological Safety, Jennifer H Chen, Alyssa A Pradarelli, Julie Evans, Niki Matusko, Norah N Naughton, Roy Phitayakorn, John T Mullen, Lily Chang, Melissa Johnson, Thavam Thambi-Pillai, Jon Ryckman, Melissa Alvarez-Downing, Nell Maloney Patel, Sebastiano Cassaro, Felicia Ivascu, David T Hughes, Gurjit Sandhu

Faculty, Staff and Students Publications

Importance: Although psychological safety has been shown to be imperative for effective learning, specific factors associated with its presence in surgical training have not been well characterized.

Objective: To identify barriers and facilitators to psychological safety for surgical trainees in the clinical learning environment.

Design, setting, and participants: This qualitative study was conducted from February 20 to May 2, 2024, among 25 trainees in general surgery and 3 surgical subspecialty programs at 9 teaching hospitals-4 university-based, 3 community-based, and 2 community-based, university-affiliated hospitals.

Exposure: Participation in surgical training.

Main outcomes and measures: Participants were asked to share their perspectives and …


Network Meta-Analysis Of Randomized Controlled Trials Comparing Safety And Efficacy Of Pharmacological Treatments In Reducing Pain During Intrauterine Device Insertion, Ahmed Ashour, Ahmed H. Saad, Iman Elzahaby Sep 2025

Network Meta-Analysis Of Randomized Controlled Trials Comparing Safety And Efficacy Of Pharmacological Treatments In Reducing Pain During Intrauterine Device Insertion, Ahmed Ashour, Ahmed H. Saad, Iman Elzahaby

Sultan Qaboos University Medical Journal

Conflicting evidence exists regarding the effectiveness of pharmacological interventions in reducing pain during intrauterine device (IUD) insertion. This study aimed to evaluate the safety and efficacy of various analgesics and to rank their effectiveness. A total of 71 randomized controlled trials (RCTs) involving 10,870 women were included. Data were sourced from PubMed, Cochrane Library, Scopus, and other databases up to September 2023. Analyses were performed using the Netmeta package in R, with results reported as standardized mean differences (SMDs) and risk ratios (RRs), each with corresponding 95% confidence intervals (CIs). Lidocaine 4% gel (5 mL) emerged as the most effective …


Effects Of Acute Caffeine Ingestion On Physical Performance And Skill Execution In Volleyball Players: A Systematic Review And Meta-Analysis, Raoof Negaresh, Shihab Aldin A. Al-Riyami, Alireza Paahoo, Rastegar Hoseini, Juan Del Coso Sep 2025

Effects Of Acute Caffeine Ingestion On Physical Performance And Skill Execution In Volleyball Players: A Systematic Review And Meta-Analysis, Raoof Negaresh, Shihab Aldin A. Al-Riyami, Alireza Paahoo, Rastegar Hoseini, Juan Del Coso

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 922-948, 2025. It is well established that oral caffeine administration (3-9 mg/kg) is ergogenic, enhancing numerous aspects of physical performance including strength and power. However, the extent to which these effects translate to volleyball-specific skills remains unclear. The purpose of this study was to systematically review the effects of acute caffeine ingestion on performance outcomes in volleyball-specific actions. A systematic review of published studies was conducted using scientific databases from their inception through December 2024 (registered in PROSPERO, CRD420251006314). We included studies with blinded crossover experimental designs that compared caffeine ingestion to a placebo …


Healing The Sacred: The Fight To Restore Onondaga Lake And Honor Indigenous Land, Adam Dj Brett, Betty Lyons Hill Sep 2025

Healing The Sacred: The Fight To Restore Onondaga Lake And Honor Indigenous Land, Adam Dj Brett, Betty Lyons Hill

International Journal on Responsibility

The Onondaga Nation is petitioning the Organization of American States (OAS) for land rights to Onondaga Lake, a notoriously polluted body of water in Central New York State. The Onondaga Nation is one of six nations of the Haudenosaunee Confederacy (Iroquois), and Onondaga Lake is the sacred site where Gayanashagowa, the Great Law of Peace, was established. As Keepers of the Central Fire, the Onondaga Nation bears the responsibility of maintaining unity and peace within the Haudenosaunee Confederacy. This article examines the history of the lake, its significance to the Haudenosaunee Confederacy, and the consequences of its desecration through …


Make It Pink: Superman, Pink Kryptonite, And Fandom, Tom Ue, Kristofer Starzomski-Wilson Sep 2025

Make It Pink: Superman, Pink Kryptonite, And Fandom, Tom Ue, Kristofer Starzomski-Wilson

Proceedings from the Document Academy

This paper explores several representations of pink kryptonite. In Doug Murphy’s animated short film True Colors (2017), Superman (Jason J. Lewis) transforms into a woman when he’s exposed to this substance. This short, as we have shown elsewhere (2025), offers a useful lens for examining the perpetuation and the critique of gender stereotypes in superhero media: Superman may be equally capable regardless of his sex, but the film pokes fun at, rather than celebrates, his transformation. Pink kryptonite rarely appears in the canon. A single panel in Supergirl (2003) has received perhaps the most sustained attention. Tom Ue’s archival work …


How Subversive Is Shipping Really? An Analysis Of Heteronormative Elements In Same-Sex Relationships Focused On German-Language Anime And Manga Fan Fiction, Saskia Dreßler Sep 2025

How Subversive Is Shipping Really? An Analysis Of Heteronormative Elements In Same-Sex Relationships Focused On German-Language Anime And Manga Fan Fiction, Saskia Dreßler

Proceedings from the Document Academy

This study investigates whether German-language fan fictions featuring lesbian and gay characters within the anime and manga domain can be regarded as genuinely queer. It situates these fan works within the specific traditions and practices of German fandom. Employing qualitative content analysis, the research examines two prominent fandoms, Naruto and Sailor Moon, focusing on the presence of heteronormative narrative patterns in fan fiction with queer protagonists. The study analyzes which aspects of the original media are adapted and how these adaptations shape the portrayal of queer identities. Furthermore, fan comments are examined to assess the extent to which readers …


An Exceptive Account Of ‘Unless’ Clauses: Corpus Evidence, Wajed Al-Ahmad Sep 2025

An Exceptive Account Of ‘Unless’ Clauses: Corpus Evidence, Wajed Al-Ahmad

Jordan Journal of Applied Science-Humanities Series

This paper provides corpus evidence to demonstrate that ‘unless’ clauses function like exceptive constructions (ECs). It adopts Galal et al. (2019) classification of ECs into two categories: paradigmatic ECs (connected/regular exceptive) and hypotactic ECs (free exceptive). The current analysis applies this classification to ‘unless’ clauses to examine their behavior. Corpus evidence shows that unless clauses consistently occupy a fixed position relative to their antecedent, similar to paradigmatic ECs. However, the two constructions differ in that ‘unless’ clauses occur before the antecedent regardless of the position of the consequent (the statement), whereas paradigmatic ECs occur after the antecedent. Additionally, unless allows …


A Content Analysis Of Pronunciation And Spelling Activities In Action Pack Ten, Sana’ Al-Smadi, Ruba Bataineh, Mohammad Al-Hawamdeh Sep 2025

A Content Analysis Of Pronunciation And Spelling Activities In Action Pack Ten, Sana’ Al-Smadi, Ruba Bataineh, Mohammad Al-Hawamdeh

Jordan Journal of Applied Science-Humanities Series

Pronunciation and spelling are crucial skills for any intelligible form of spoken or written communication. Both serve as important indicators—among others—that determine the quality of speech or writing. However, EFL learners often face challenges with these fundamental skills during real-life communication. This content analysis aims to examine whether pronunciation and spelling are adequately covered in the Student Book and Activity Book, the extent to which these activities are emphasized, and their focus within Action Pack 10. To achieve these objectives, a mixed-methods approach was employed, including the development of four content analysis sheets. Frequencies and percentages were used for analysis, …


The Effect Of Using The Snowball Strategy On Reading Speed Among Third Grade Students In Mafraq District Directorate, Noor Al-Khaza'leh Sep 2025

The Effect Of Using The Snowball Strategy On Reading Speed Among Third Grade Students In Mafraq District Directorate, Noor Al-Khaza'leh

Jordan Journal of Applied Science-Humanities Series

This study aimed to investigate the effect of using the snowball strategy on the reading speed of third-grade students in Mafraq Directorate. The researcher employed a quasi-experimental design. The study was conducted on a purposive sample of 34 third-grade students from two selected schools. The experimental group consisted of 18 students, while the control group included 16 students. The results indicated that the use of the snowball strategy significantly improved overall reading speed as well as individual rapid reading skills. The effect size ranged from 16.3% to 33.5%. The study recommended using the snowball strategy in teaching reading skills and …


The Effect Of The Hot Seat Strategy On Listening Comprehension Skills In The Arabic Language Subject Among Ninth Grade Female Students In Jordan, Zikrayat Al-Amro, Raed Mahmoud Khodair, Khaled Al-Omari Sep 2025

The Effect Of The Hot Seat Strategy On Listening Comprehension Skills In The Arabic Language Subject Among Ninth Grade Female Students In Jordan, Zikrayat Al-Amro, Raed Mahmoud Khodair, Khaled Al-Omari

Jordan Journal of Applied Science-Humanities Series

The study aimed to investigate the effect of the Hot Seat strategy on listening comprehension skills in Arabic among ninth-grade female students at Al Mazar Secondary Comprehensive School, under the Northern Mazar District Education Directorate. The participants consisted of 67 female students selected by the convenience sampling method. The students were divided into two groups: an experimental group and a control group. Prior to the intervention, all students were pretested in listening comprehension skills at the beginning of the second semester of 2018/2019. The experimental group received training on listening comprehension skills using the Hot Seat strategy, while the control …


The Effect Of Using Semantic Maps On Vocabulary Learning Among Jordanian Efl 8th Grade Students, Bassmah Fraihat Sep 2025

The Effect Of Using Semantic Maps On Vocabulary Learning Among Jordanian Efl 8th Grade Students, Bassmah Fraihat

Jordan Journal of Applied Science-Humanities Series

This study investigated the effect of using semantic maps on vocabulary retention among Jordanian EFL 8th-grade students. The participants were 83 female eighth-grade students from two intact sections at Balleh Secondary School for Girls. One group was assigned as the control group, which was taught according to the guidelines of the teacher's book, while the other group served as the experimental group and was taught using a semantic map-based instructional program. The instructional program lasted for eight weeks during the first semester of the 2018-2019 academic year. Data were collected using pre- and post-vocabulary tests. The findings showed statistically significant …


Psychometric Properties Of The Jordanian Picture Test From The Wexler-4 Intelligence Scale In Sign Language For The Deaf (Ages 6–16.11 Years), Samer Abu Drea, Farouq Al-Rawsan Sep 2025

Psychometric Properties Of The Jordanian Picture Test From The Wexler-4 Intelligence Scale In Sign Language For The Deaf (Ages 6–16.11 Years), Samer Abu Drea, Farouq Al-Rawsan

Jordan Journal of Applied Science-Humanities Series

This study focuses on developing and validating a Jordanian version of the WISC-4 intelligence scale in sign language for deaf children aged 6 to 16.11 years. The aim is to assess the psychometric properties, including validity and reliability, of this version to serve as a trustworthy tool for measuring the cognitive abilities of deaf children in Jordan using sign language, aligned with their linguistic and cultural characteristics. A descriptive approach was employed, and the sample consisted of 413 deaf children from various regions across the country. The results demonstrated that the Jordanian version exhibits high content validity, with strong correlations …


The Effect Of An Electronic Collocation-Based Instructional Program On Jordanian Efl Tenth Graders’ Word Knowledge, Marouf Assaf, Dina Al-Jamal, Ebtesam Rababah Sep 2025

The Effect Of An Electronic Collocation-Based Instructional Program On Jordanian Efl Tenth Graders’ Word Knowledge, Marouf Assaf, Dina Al-Jamal, Ebtesam Rababah

Jordan Journal of Applied Science-Humanities Series

This quasi-experimental study investigated the effectiveness of an electronic collocation-based instructional program on Jordanian EFL tenth-grade students' word knowledge. Two sections of 25 students each, from a government school in Irbid, were randomly assigned as experimental and control groups. A word knowledge pre-test, which included a section measuring word meaning and another assessing word collocation, was administered to determine whether the two groups were homogeneous before implementing the program. Lexical collocations in Action Pack 10 were identified through a content analysis of selected reading passages, and these collocations were taught to the experimental group using Quizlet, a flashcard mobile application. …


Experimental And Theoretical Studies Of Novel Resilient Smart Shear Keys For Speedy Functional Recovery Of Highway Bridges After Extreme Events, Xinzhe Yuan, Jun Han, Jian Zhong, Haibin Zhang, Genda Chen Sep 2025

Experimental And Theoretical Studies Of Novel Resilient Smart Shear Keys For Speedy Functional Recovery Of Highway Bridges After Extreme Events, Xinzhe Yuan, Jun Han, Jian Zhong, Haibin Zhang, Genda Chen

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Sacrificial shear keys in small-to-medium-span highway bridges mainly provide lateral support to the bridge superstructure under extreme events such as earthquake and/or tsunami. However, such support could lead to irreparable harm to important bridge elements like abutments and bent caps (base), delaying the functional recovery of bridges in the aftermath. In addition, existing designs of the shear key primarily emphasize resistant capacity but overlook resilience. This study introduces a new sliding, modular, adaptive, replaceable, and two-dimensional (SMART) shear key designed to enhance the resilience of I-girder highway bridges. The SMART shear key has three primary goals: 1) enabling the rapid …


Positive Effects Of Sulfates On Performance Of Cement Paste Incorporating Low-Grade, High-Aluminum Steel Slag, Nannan Zhang, Gao Deng, Wenyu Liao, Chuanlin Hu, Hongyan Ma Sep 2025

Positive Effects Of Sulfates On Performance Of Cement Paste Incorporating Low-Grade, High-Aluminum Steel Slag, Nannan Zhang, Gao Deng, Wenyu Liao, Chuanlin Hu, Hongyan Ma

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Steel slag with high aluminum (Al) content significantly delays the early hydration of cement when used as a supplementary cementitious material (SCM). To address this challenge, this study investigates the effects of gypsum (Gy) and sodium sulfate (SS) additions on the performance of cement pastes with 30 % high-Al ladle metallurgy furnace (LMF) slag. The mechanical properties, hydration kinetics, phase evolution, as well as the early-age hydration mechanism were explored. The results indicate that C3S hydration is substantially inhibited under high-Al conditions, mainly attributed to the rapid dissolution and reaction of reactive aluminates (particularly mayenite) in the slag. Both Gy …


Generalized Transversality Conditions For Fuzzy Quantum-Symmetric Variational Problems Via Granular Approach, Martin Bohner, Ewa Girejko, Agnieszka B. Malinowska, Linh Nguyen, Baruch Schneider, Tri Truong Sep 2025

Generalized Transversality Conditions For Fuzzy Quantum-Symmetric Variational Problems Via Granular Approach, Martin Bohner, Ewa Girejko, Agnieszka B. Malinowska, Linh Nguyen, Baruch Schneider, Tri Truong

Mathematics and Statistics Faculty Research & Creative Works

This paper investigates fuzzy q-symmetric variational problems with natural boundary conditions. Based on the relative distance measure fuzzy arithmetic and horizontal membership functions (HMFs), we propose novel concepts of differentiability and integrability for fuzzy functions on quantum geometric subsets of real numbers. Then, fundamental foundations of q-symmetric calculus of variations based on HMFs are provided. With the help of HMFs and granular q-symmetric differentiability, we derive necessary optimality conditions for fuzzy q-symmetric variational problems that depend on free endpoints. Moreover, sufficient conditions for minimizers of q-symmetric variational problems are obtained. Some numerical examples illustrating the proposed approach are presented.


What Next? A Challenging Case Of Refractory Hypertension With End-Organ Dysfunction In A 33-Year-Old Male, Rezane Miftari Md, Shaun Abid, Anton Stolear, Irma Fotjhadi Sep 2025

What Next? A Challenging Case Of Refractory Hypertension With End-Organ Dysfunction In A 33-Year-Old Male, Rezane Miftari Md, Shaun Abid, Anton Stolear, Irma Fotjhadi

Posters

We present a challenging case of a 33-year-old male with history of longstanding hypertension since high school, which progressed to RH complicated by severe left ventricular hypertrophy and hypertensive nephrosclerosis.


Novel Statistical And Topological Data Analyses Of 2d Electronic Images, Robert L. Paige, Vic Patrangenaru Sep 2025

Novel Statistical And Topological Data Analyses Of 2d Electronic Images, Robert L. Paige, Vic Patrangenaru

Mathematics and Statistics Faculty Research & Creative Works

In this paper, novel statistical and topological data analyses of 2D images are developed. One considers methodologies based on the Region Covariance Descriptor (RCD) and Topological Data Analysis (TDA) rooted in the simplicial as well as cubical persistent homologies. These methods provide statistical methods for data from populations of complex data objects that are elements of non-Euclidean spaces. The 2D image data considered consist of pictures of two leaves—A and B—from the same tree, twenty of each leaf, from different perspectives. The novel statistical procedures developed are used for correctly determining that leaf A images and leaf B images are …


The Information Edge - Library Newsletter - September 2025, Sarah Burns-Feyl, Jennifer Rosenstein Sep 2025

The Information Edge - Library Newsletter - September 2025, Sarah Burns-Feyl, Jennifer Rosenstein

University Library Newsletter

No abstract provided.