Differential Effects Of Macrophage Subtype-Specific Cytokines On Fibroblast Proliferation And Endothelial Cell Function In Co-Culture System, Phillip Mcclellan, Thomas R. Wong, Sara Hijaz, David R. Fletcher, Ozan Akkus, Tracey L. Bonfield, James M. Anderson, Adonis Hijaz

Faculty Scholarship

Macrophages are involved in several critical activities associated with tissue repair and regeneration. Current approaches in regenerative medicine are focusing on leveraging the innate immune response to accelerate tissue regeneration and improve long-term healing outcomes. Of particular interest in this regard are the currently known, four main M2 macrophage subtypes: M2interleukin (IL)-4,IL-13, M2IC, M2IL-10, M2non-selective adenosine receptor agonists (NECA) (M2IL-4,IL-13 → M2(NECA). In this study, rat bone marrow-derived macrophages (M₀) were polarized to each of the four subtypes M2IL-4,IL-13 → M2NECA and cultured for 72 h in vitro. Luminex assay results highlighted increased production of tissue inhibitor of metalloproteinases-1 (TIMP-1) …

Dementia As A Critical Lens On The Role Of Narrative In Medical Training And Practice, Erin Gentry Lamb

Faculty Scholarship

Narrative holds an important place within medicine and medical education, but an uncritical use of narrative can have troubling consequences for the care of patients who have limited or no capacity for self-narration, such as those living with dementia. We argue that the guiding principles in the use of narrative within medicine and medical education must be inclusivity and opportunity. We illustrate how medical training can benefit from a more inclusive definition of narrative, and we present a selection of innovative approaches to narrative coming out of literary studies, narrative gerontology, and medical and health humanities that focus on metaphor, …

Introduction, Rosalind Latiner Raby

Journal of Comparative & International Higher Education

No abstract provided.

The Cowl - V. 89 N. 1 - September 18, 2025

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 1 - September 18, 2025. 20 pages.

Full Pdf Issue 17(4) 2025

Journal of Comparative & International Higher Education

No abstract provided.

Cetuximab Increases Lgr5 Expression And Augments Lgr5-Targeting Antibody-Drug Conjugate Efficacy In Patient-Derived Colorectal Cancer Models, Peyton C High, Zhengdong Liang, Cara Guernsey-Biddle, Shraddha Subramanian, Yueh-Ming Shyu, Adela M Aldana, Yukimatsu Toh, Kendra S Carmon

The Brown Foundation: Institute of Molecular Medicine

Colorectal cancer (CRC) remains the second-leading cause of cancer-associated deaths, indicating an urgent need for improved therapeutic options. We previously generated antibody-drug conjugates (ADCs) targeting the cancer stem-like cell marker leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5). However, tumor relapse due to LGR5 downregulation and suboptimal payload selection warrants strategies to improve ADC efficacy. Here, we report that cetuximab, an epidermal growth factor receptor (EGFR)-targeting monoclonal antibody indicated for RASWT metastatic CRC, augments LGR5 expression independent of RAS/PIK3CA mutation status and promotes EGFR-LGR5 interactions. Furthermore, we describe the development of LGR5 ADCs incorporating a camptothecin-derived payload that is well tolerated …

Nigerian Immigrant Mothers’ Parenting Style In Supporting Academic Achievement In Their Children, Ganiyat Olasumbo Saidu

Walden Dissertations and Doctoral Studies

Supporting their children’s academic activities while navigating the socioeconomic norms of the new system continues to be a significant challenge for most immigrant parents in urban areas of the United States. However, there is inadequate literature on the parenting behaviors used by Nigerian immigrant parents to support their children’s academic achievement. The purpose of this qualitative study was to understand how Nigerian immigrant mothers describe the parenting styles that support their children’s academic achievement. The theoretical framework for this study was Bandura’s (1977) social cognitive theory and Baumrind’s (1966) theory of parenting styles. For this basic qualitative study, the population …

Leading Through Crisis: Lessons In Leadership From New Jersey Administrators During The Covid-19 Pandemic, Alicia Subervi

Seton Hall University Dissertations and Theses (ETDs)

ABSTRACT

This qualitative comparative case study examined the lived experiences of building- and district-level administrators in a single New Jersey school district as they navigated the unprecedented challenges of the COVID-19 pandemic. The study explored how administrators perceived and responded to disruptions, how responses evolved over time, lessons learned, and the ways these insights are being applied in schools today. Data were collected from demographic and technology surveys, two rounds of semi-structured interviews, and a targeted review of district documents. Analysis was conducted using a combination of a priori and emergent coding to identify 27 codes organized into nine overarching …

Mymoney: A Program That Leverages Digital And Artificial Intelligence Tools For Improving The Financial Wellbeing Of Hispanic Families, Luisa Blanco, Kamila Campos, Jessica Gonzalez, Jorge Macias

School of Public Policy Working Papers

Abstract: Our Community-Based Digital Intervention (CBDI) MyMoney was designed to meet the informational needs and promote behavioral change among Hispanic adults. We leverage Digital and Artificial Intelligence (DAI) tools to provide participants access to content that is linguistically and culturally tailored and structured to be delivered in short, accessible modules. MyMoney program provided an introductory experience to financial education with a mobilephone based approach, offering a four-week experience for improving money management skills. We conducted an extensive quantitative and qualitative data analysis of participants’ and stakeholders’ program experience and perspectives, which provides important insights for the design, evaluation, and implementation …

Who Gets Stitches? The Effects Of Rewarding Whistleblowers And Protecting Their Identity On Subsequent Willingness To Work With Others, Ryan D. Sommerfeldt

Faculty Publications

Companies are strongly encouraged to implement whistleblowing programs to help detect and deter misconduct in organizations, but whistleblowers often face ostracism as their coworkers are less willing to work with them (the whistleblower effect). Rewarding the whistleblower and protecting the whistleblower’s identity are two highly recommended features of whistleblowing programs that aim to encourage reporting. Across two experiments, I examine the spillover effects of these whistleblowing program features on how willing employees are to work with their coworkers after reporting occurs. I find that providing a reward to the whistleblower exacerbates the whistleblower effect, leading employees to work even less …

Sensory And Chemical Characterization Of Upcycled Pomace- And Whey-Based Piquette Beverages, Dean G. Hauser, Rahul Sen, Scott R. Lafontaine, Chris Gerling, Luann M. Preston-Wisley, Timothy A. Demarsh, Samuel D. Alcaine

Food Science Faculty Publications and Presentations

Upcycling, or utilizing materials that would otherwise go to waste, enables the creation of novel products that offer sustainability advantages and generate additional value. This study evaluates the feasibility of producing alcoholic beverages using yogurt acid whey (YAW) and grape pomace (GP), byproducts of the dairy and wine industries, respectively, and compares them to commercial grape pomace beverages (piquettes) in terms of sensory attributes and chemical composition. Two YAW-GP piquettes were produced, and five commercial piquettes were obtained. Sugars and organic acids were quantified using HPLC-RID, and semi-quantitative volatile composition was determined using HS-SPME-GC-MS/MS. Descriptive analysis was conducted using a …

September 18, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Efficacy And Safety Of Rigosertib In Patients With Recessive Dystrophic Epidermolysis Bullosa-Associated Advanced/Metastatic Cutaneous Squamous Cell Carcinoma, Martin Laimer, Andrew P. South, Elisabeth Mayr, Sophie Kitzmueller, Lauren Banner, Michael Alexander, Linda Hosler, Henry Yang, Matthew Parris, Meena Arora, Georg Zimmermann, Gregor Schweighofer-Zwink, Johann Bauer, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Recessive dystrophic epidermolysis bullosa (RDEB) is an epithelial fragility disease primarily affecting the skin and is caused by variants in the COL7A1 gene. Individuals with RDEB are predisposed to develop highly aggressive cutaneous squamous cell carcinomas (SCCs) which are the most common cause of premature death. There is a lack of effective prevention or treatment options for patients with RDEB-SCC.

OBJECTIVES: To evaluate the antitumour activity and safety of the polo-like kinase-1 (PLK1) inhibitor, rigosertib, two investigator-initiated open-label, single-arm phase II studies were opened in Europe and the USA and enrolled five patients with RDEB diagnosed with locally advanced …

Kenyon Collegian - September 18, 2025

The Kenyon Collegian

No abstract provided.

Connecting Innovation And Trust Through Translational Sciences – A Need For A Community Focus And Effective Education Strategiess, Filipa Godoy-Vitorino, Michelle Borrero, Josué Pérez-Santiago, Rubén García-García, Candelaria Gomez-Manzano

Faculty, Staff and Student Publications

Report of a conference held in Puerto Rico, this article highlights how interdisciplinary translational science-anchored in education, public trust, and equity-can accelerate innovation in cancer therapy while empowering underserved communities through inclusive training, collaboration, and research participation.

Socio-Economic Risk Of Rising Compound Precipitation-Wind Extremes In San Francisco Bay Area, Nikhil Kumar, Gregory Brian Pasternack, Yufang Jin, Serena Alexander, Zhihao Wang, Costanza Rampini, Rune Storesund, Chris Lim, Stephanie Moreno, Igor Lacan

Faculty Research, Scholarly, and Creative Activity

Compound precipitation-wind extremes (CPWEs) pose significant socio-economic challenges in urban areas, with the most severe impacts often felt by vulnerable populations. While CPWE studies have often focused on large-scale assessments, localised urban contexts, at a scale of a city and its suburban surroundings, remain understudied, particularly in terms of how CPWEs might differentially impact different socio-economic communities. This study aims to advance understanding of how CPWEs interact with social vulnerability at a localised scale, using the San Francisco Bay Area (SFBA)—a global hotspot for CPWEs with diverse climates, physiography, and socio-economic factors—as a test case. Daily precipitation and wind speed …

Editorial: Wearable Technology: The New Ornament Of Network Physiology, Ankita Srivastava, Santosh Kumar Yadav

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Introduction: The landscape of personal health monitoring is rapidly transforming, driven by advances in wearable technology. These devices, designed to be worn comfortably on the body, can capture real-time physiological data often difficult to obtain in traditional clinical settings. What began as a simple device for activity trackers for walking steps, heart rate, and blood oxygen saturation has evolved to play a crucial role in monitoring more complex physiological parameters critical for chronic disease management and preventative health.

The integration of artificial intelligence (AI) is further expanding the potential of wearable devices, enabling deeper analysis and predictive modeling of the …

Disparities In Liver Transplantation For Metabolic Dysfunction-Associated Steatohepatitis-Associated Hepatocellular Carcinoma, David W Victor, Sudha Kodali, Mazen Noureddin, Elizabeth W Brombosz, Analisa Lopez, Tamneet Basra, Edward A Graviss, Duc T Nguyen, Ashish Saharia, Ashton A Connor, Maen Abdelrahim, Yee Lee Cheah, Caroline J Simon, Mark J Hobeika, Constance M Mobley, R Mark Ghobrial

Faculty, Staff and Students Publications

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is increasingly common, as is hepatocellular carcinoma (HCC) in the background of MASH. Liver transplantation (LT) provides superior long-term survival for patients with unresectable MASH-HCC, but not all patients have equal access to transplant. MASH-HCC disproportionately affects Hispanic patients, but minorities are less likely to undergo LT for HCC. Additionally, females also undergo LT at lower rates than males.

Aim: To investigate whether race/ethnicity and sex affect LT waitlist outcomes.

Methods: Records of adults with MASH-HCC in the United States Organ Procurement and Transplantation Network database listed for LT between 1/2015 and 12/2021 were analyzed. …

Rat Somatic Genome Editing Enables Er+ Breast Cancer Modeling, Wen Bu, Tobie Lee, Meenakshi Anurag, Yunfeng Ding, Ruixin Xu, Lillian He, Alexandria Z Bu, Chandandeep Nagi, Carolina Gutierrez, Susan Hilsenbeck, Chonghui Cheng, Bing Zhang, Shixia Huang, Jianming Xu, C Kent Osborne, Arun Sreekumar, Eric Chang, Chad J Creighton, Xiang Zhang, Yi Li

Faculty, Staff and Students Publications

Genetically engineered mouse models have advanced cancer research but often fail to capture key features of certain human tumors. Rats, with distinct physiology and tumor biology, offer a powerful alternative, yet their use has been constrained by technical barriers to genome editing. Here, we report efficient somatic genome editing in rats, enabling both Indel and substitution mutations. We then apply this approach to model estrogen receptor (ER)-positive breast cancer, which accounts for ~70% of human cases but remains poorly represented in mice. The resulting rat tumors reproduce hallmarks of human ER+ breast cancer, including ductal histology, hormone responsiveness, and immune-microenvironmental …

Decolonizing Colombian Foreign-Language Classroom Assessments: A Meaningful Framework, Patricia Grillet Rodriguez

Journal of Comparative & International Higher Education

In Colombia, foreign-language evaluation validity appears to be mainly related to the analysis of instruments, leaving aside students’ characteristics, affective schemata and expectations. Drawing from critical pedagogy, this study aimed at raising authenticity and meaningfulness in the development of valid foreign-language assessments in a higher education classroom. Framed in the sociocultural perspective, the teacher/researcher and her students obtained substantial gains by adapting a syllabus and evaluation system to better respond to the needs of their context. It was a collaborative process that implied contextualizing contents, establishing a concept of language ability, and including students’ voices in the design of assessments, …

An Autoethnographic Study: Perspectives And Insights Of A Cross-Cultural Educator On Curriculum And Pedagogical Variation In Internationalization Of Higher Education, L. Ge

Journal of Comparative & International Higher Education

This auto-ethnographic inquiry utilizes autobiographical narrative to delve into my experiences and narratives as a cross-cultural educator simultaneously teaching at a Chinese and Canadian university. The aim is to ponder the interconnections, differences, and challenges within formal cross-cultural curriculum design and pedagogy, informal curriculum, and hidden curriculum and engage with academic environments and broader communities. Specifically, the study will examine the content, teaching methodologies, student learning, assessment practices, and the learning environment based on my experiences in an intercultural educational setting, as well as my coping strategies. The constructivist paradigm serves as the theoretical framework to explore my perceptions and …

Do Micro-Level Support Areas Impact International Students’ Perceived Academic Success?, Taiwo O. Soetan

Journal of Comparative & International Higher Education

This study examined the micro-level support areas for international students at a higher education institution (polytechnic) in Canada to determine their perceived academic success using the Bronfenbrenner theory of human development at the micro-level. A quantitative study was conducted to measure the impact of micro-level support areas on international student’s perceived academic success. A target sample of 399 international students was recruited to participate in a hard copy, one on one survey in the 2019 winter semester. The results of this study show that international students’ support areas at the micro-level were strongly related to their perceived academic success. The …

Smartphone-Based Ecological Momentary Assessment (Ema) Tool To Collect Momentary Psychological Data From Older Adults With Mild Cognitive Impairment (Mci): A Feasibility And Acceptability Study., Rose Lin

Sigma Foundation for Nursing Research Grant Reports

Using a user-centered approach, the specific aim is to develop a feasible and acceptable smartphone-based EMA protocol to collect real-time psychological data, including momentary emotions, perceived stress levels, and environmental stressors from individuals with MCI in their everyday environments. Such a tool is a crucial step that enables testing of the theoretical framework underlying neuropsychiatric symptoms (NPS) in MCI, a significant and prevalent risk factor known to speed up progression to dementia. We will evaluate the feasibility and acceptability of this tool by examining adherence metrics (completion rate, compliance rate, response latency, number of technical support requests), and conducting qualitative …

Seeing Google At 25, Paul A. Soukup S.J.

Communication Research Trends

Seeing Google at 25

1. History . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

A. Fits and starts to dominating the world . . . . . 5

2. Google in the Eyes of Scholars: Google Services 8

A. Digital library . . . . . . . . . . . . . . . . . . . . . . . . . 8

B. Google Earth and Google Maps . …

Toward An Understanding Of Tax Complexity, Daniel Schaffa

Florida Tax Review

The study of tax complexity has reached consensus on two things. First, complexity pervades the U.S. tax system. And second, it is not always clear what tax complexity means. Indeed, it is common practice for tax complexity scholarship to note the absence of a universal tax complexity definition and then conduct its inquiry without one. A universal definition of tax complexity has proven elusive because tax complexity means many different (although often related) things. This has made the tax policy analysis of complexity challenging. As an alternative to a definition, this Article proposes a framework with four elements for considering …

Do Tax Judges Favor The Tax Authority?, Orli Oren-Kolbinger

Florida Tax Review

Judges and judicial systems have become more specialized in response to increasing legal complexity. While the theoretical literature has discussed judicial specialization extensively, deliberating its pros and cons and its implications—arguably an appealing background for empirical investigation—few empirical studies have attempted to quantify the relationship between judicial specialization and case outcomes. This Article fills that lacuna. It analyzes a hand-coded dataset of tax cases in which rulings were made by both specialized tax judges and generalist judges in Israeli District Courts. Its main finding is that specialized tax judges are more inclined than generalist judges toward the Tax Authority. It …

‘Leading Research From A Remote Community-Based Perspective’, Robyn Ober

Talking Heads Seminar Series

In an ideal world, Aboriginal and Torres Strait Islander people are those best positioned to undertake research with Indigenous Australians, whether in rural, remote or urban community contexts. While this is not always possible, it is important that research projects should at least be designed and conducted in collaboration with Aboriginal and Torres Strait Islander people. This is to the advantage of all stakeholders, including universities and organisations that have a vested interest in envisioning a better future for Indigenous Australians. To this end, Community-based researchers play a pivotal role in working with organisations to initiate, lead and implement research …

Contextual Analysis Of Physical-Tactical Match Performance Demands In Elite U21 Soccer Players, Craig Davies, Christian Vassallo, Ben Ryan, Piotr Zmijewski, Rafael Oliveria, José E. Teixeira, Alexandre Moreira, Ryland Morgans

Baltic Journal of Health and Physical Activity

Background: Soccer matches include physical and tactical factors, yet limited research has integrated physical-tactical variables involving U21 soccer players. This study examined how different phases of play influence physical intensity in elite U21 soccer players. Materials and Methods: Twelve professional development league matches involving 29 male U21 soccer players (106 observations) were analysed. Players wore 10 Hz GPS units to derive relative (m/min) physical metrics during six phases of play. Phases and positions were compared using repeated‑measures ANOVA and one‑way ANOVA. Results: Players covered significantly greater high-speed running per minute (HSR/min) during the final third compared to build-up (p …

Beyond Description: Interrogating Narrative Elements In Archival Finding Aids, David J. Williams, Richard Kearney

Journal of Contemporary Archival Studies

As the archival profession evolves, attention is increasingly paid to the usability of its resources and services. User Experience, or UX, is a contemporary design practice gaining prominence among archivists interested in addressing usability. Information design, the process of organizing and presenting information for efficient and effective use, is a component of UX incorporating both the presentation and content of communication instruments, with plain language writing guidelines applied toward achieving this goal. A prominent information artifact produced by archivists is the finding aid, describing and inventorying archival collections. Those components of finding aids providing “access points” into collections—communicating the …

Between Foreignization And Domestication: A Corpus-Based Study Of The Translation Of Food-Related Cultural References In The Arabic Subtitling Of 90 Hollywood Films, Eisa Ahmad Saeed Asiri

UB Journal for Humanities

This paper explores the translation of food-related cultural references (FCRs) from spoken English into Arabic subtitles based on analysis of a corpus-driven mixed-method of 90 Hollywood films. Using the AVT-FoodCorpus90, a 1.4-million-word English-Arabic parallel corpus, the study examines how subtitlers work to balance foreignization and domestication in the process of translating culturally specific food items. The results reveal that the most popular strategy is that which relies on foreignization through transference (29.8%), followed by literal translation (25.1%) and intratextual glosses (15.4%), creating a new trend in Arabic subtitling that promotes cultural visibility and creates intercultural interaction. However, domestication remains necessary, …