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Technical And Vocational High School Training And Graduates' Socioeconomic Insertion In Burkina Faso, Jacqueline Nikièma Aug 2026

Technical And Vocational High School Training And Graduates' Socioeconomic Insertion In Burkina Faso, Jacqueline Nikièma

Educational Leadership & Workforce Development Theses & Dissertations

Technical and vocational education and training (TVET) is widely promoted as a pathway to improving employment opportunities, supporting economic growth, and facilitating successful labor market transition. However, empirical evidence on its effectiveness remains limited in Burkina Faso. This study examined the relationship between TVET high schools and graduates’ socioeconomic insertion, with particular emphasis on employment in occupations related to the field of study (horizontal match) and examined the relationship between gender and this employment outcome. The study used descriptive statistics to summarize the characteristics of the sample, and logistic regressions to analyze the relationship between TVET training and employment in …


Faculty Conceptualizations Of Recreational Therapy And Disability: Influences On The Formal, Hidden, And Null Curricula In Undergraduate Recreational Therapy Education, Shelly Lynne Beaver Aug 2026

Faculty Conceptualizations Of Recreational Therapy And Disability: Influences On The Formal, Hidden, And Null Curricula In Undergraduate Recreational Therapy Education, Shelly Lynne Beaver

Human Movement Studies & Special Education Theses & Dissertations

Undergraduate education is a bedrock of professional preparation for entry-level recreational therapists, shaping their scope of practice, philosophical orientations, and approaches to service delivery. While significant attention has been given to the development of a formal recreational therapy curriculum – explicitly taught knowledge, skills, and competencies – little is known about the hidden and null curricula that may implicitly or unintentionally shape students’ professional identities, values, and beliefs. While these less explicit curricular dimensions may have profound effects on how preservice recreational therapists conceptualize both recreational therapy and disability, their impact remains largely unknown. Therefore, the aim of this research …


Making Sense Of Generative Ai: A Qualitative Single Case Study Examining How College Students Describe Its Use In Academic Coursework, Hollie L. Reese Aug 2026

Making Sense Of Generative Ai: A Qualitative Single Case Study Examining How College Students Describe Its Use In Academic Coursework, Hollie L. Reese

Electronic Theses and Dissertations

Generative artificial intelligence has become increasingly present in higher education, creating opportunities and challenges related to teaching, learning, academic integrity, and student preparation for future professional settings. The problem addressed in this study was the growing misalignment between students’ use of generative artificial intelligence tools and the guidance, expectations, and policies provided within college courses. The purpose of this qualitative case study was to explore how college students described their use of these tools in academic courses and to identify the benefits and challenges associated with integrating them into learning experiences. Data were collected through semistructured interviews with undergraduate students …


The Rending Of The Temple Curtain In The Gospel Of Luke: Its Relocation And Implications, Kim Kai Chan Aug 2026

The Rending Of The Temple Curtain In The Gospel Of Luke: Its Relocation And Implications, Kim Kai Chan

Electronic Theses and Dissertations

The rending of the temple curtain at Jesus’s death is recorded in all three Synoptic Gospels, yet Luke relocates the event from after to before Jesus’s death, creating interpretive challenges. While Mark connects the curtain’s tearing to the rending of the heavens at Jesus’s baptism through the verb σχίζω, this study argues that Luke reframes the tearing motif by linking the curtain’s rending to the tearing of the new garment in the parables of Luke 5:36–39, likewise employing σχίζω.

On the one hand, these parables in Luke 5 represent Jesus’s reasoning with his critics that to resist him and his …


Cultural Intelligence And Leadership: Examining School Principals’ Impact On Teacher Belonging, Retention, And Conflict Resolution, Quincy C. Commerford Aug 2026

Cultural Intelligence And Leadership: Examining School Principals’ Impact On Teacher Belonging, Retention, And Conflict Resolution, Quincy C. Commerford

Electronic Theses and Dissertations

The increasing diversity throughout the United States, especially reflected in the school system, has increased the need for school leaders who can effectively lead culturally diverse communities, and, specifically, for culturally diverse teachers. Cultural intelligence has gradually become a leadership competency alongside other intelligences, such as emotional and social, but little is known about how a school leader’s cultural intelligence affects culturally diverse teachers sense of belonging, their experiences with conflict, and overall teacher retention. In this study the researcher examined how a school leader’s cultural intelligence affects teachers’ sense of belonging in two culturally diverse secondary school settings. Using …


Motivation And Constraints In Recreation Participation Among Children And Adults With Disabilities, Monica Klock Aug 2026

Motivation And Constraints In Recreation Participation Among Children And Adults With Disabilities, Monica Klock

Human Movement Studies & Special Education Theses & Dissertations

This dissertation investigated how motivation and constraints relate to participation in outdoor and community recreation among children with disabilities and adults who are blind or visually impaired. Although outdoor recreation is associated with important physical, psychological, and social benefits, people with disabilities continue to participate at lower rates than their peers without disabilities, and prior work shows that barriers extend well beyond physical access to include structural, interpersonal, and intrapersonal constraints. Drawing on the Constraint–Negotiation Model (CNM) and social cognitive theory, this dissertation addressed gaps in multivariate research and life-course perspectives by examining whether and how motivations, perceived constraints, and …


Harnessing Kenyan Aquaculture Through Social Media: Impacts, Challenges And Strategic Directions, Domitila Kyule, Jonathan Munguti, Mavindu Muthoka, Esther Magondu, Menaga Meenakshisundaram, Chrysantus M. Tanga, Kevin Obiero, Cecilia Githukia Aug 2026

Harnessing Kenyan Aquaculture Through Social Media: Impacts, Challenges And Strategic Directions, Domitila Kyule, Jonathan Munguti, Mavindu Muthoka, Esther Magondu, Menaga Meenakshisundaram, Chrysantus M. Tanga, Kevin Obiero, Cecilia Githukia

All Peer-Reviewed Publications

Aquaculture is increasingly important for food, nutrition and livelihoods in Kenya, but the sector still faces persistent constraints in extension delivery, farmer learning, input access, market coordination and information reliability. This review examines how social media and related digital communication tools are shaping aquaculture development in Kenya, with attention to impacts, challenges, governance needs and strategic directions. A systematic literature review of studies and institutional sources published between 2015 and 2025 was conducted. The search identified 388 records, of which 45 sources were included in the final synthesis after screening, eligibility assessment and quality appraisal. Because the evidence was heterogeneous, …


Efficient Test-Time Retrieval Augmented Generation, Hailong Yin, Bin Zhu, Jingjing Chen, Chong-Wah Ngo Aug 2026

Efficient Test-Time Retrieval Augmented Generation, Hailong Yin, Bin Zhu, Jingjing Chen, Chong-Wah Ngo

Research Collection School Of Computing and Information Systems

Although Large Language Models (LLMs) demonstrate significant capabilities, their reliance on parametric knowledge often leads to inaccuracies. Retrieval Augmented Generation (RAG) mitigates this by incorporating external knowledge, but these methods may introduce irrelevant retrieved documents, leading to inaccurate responses. While the integration methods filter out incorrect answers from multiple responses, but lack external knowledge like RAG methods, and their high costs require balancing overhead with performance gains. To address these issues, we propose an Efficient Test-Time Retrieval-Augmented Generation Framework named ET2RAG to improve the performance of LLMs while maintaining efficiency. Specifically, ET2RAG is a training-free method, that first retrieves the …


Dynamic Spectral Denoising With Global-Context Attention For Multi-Behavior Recommendation, Miaomiao Cai, Yunshan Ma, Fangqi Zhu, Junfeng Fang, Zhijie Zhang, Zhiyong Cheng, Xiang Wang, See-Kiong Ng Aug 2026

Dynamic Spectral Denoising With Global-Context Attention For Multi-Behavior Recommendation, Miaomiao Cai, Yunshan Ma, Fangqi Zhu, Junfeng Fang, Zhijie Zhang, Zhiyong Cheng, Xiang Wang, See-Kiong Ng

Research Collection School Of Computing and Information Systems

Multi-behavior recommendation improves target-behavior predic-tion by exploiting heterogeneous auxiliary feedback (e.g., view,collect, and cart), yet its robustness is often undermined by behavior-dependent noise and inconsistency. We argue that the key bottle-neck is not merely noisy behaviors, but a representation-level failurecaused by two coupled heterogeneities. First, intra-behavior rep-resentation entanglement arises when multi-hop propagationblends incidental signals with true preferences in the embeddingspace. This entanglement renders coarse spatial denoising inef-fective, since it cannot suppress noise without sacrificing weak-but-informative niche signals. Second, inter-behavior reliabilityheterogeneity complicates cross-behavior fusion, as the predic-tive value of auxiliary behaviors varies substantially across usersand contexts. Without reliability calibration, aggregation can …


Semiparametric Cointegrating Rank Selection For Curved Cross-Section Time Series, Peter C. B. Phillips Aug 2026

Semiparametric Cointegrating Rank Selection For Curved Cross-Section Time Series, Peter C. B. Phillips

Research Collection School Of Economics

Cointegrating rank selection is studied in a function space reduced rank regression where the data are time series of cross-section curves. Consistent cointegrating rank estimation is developed using information criteria extended to curve time series environments. The asymptotic theory involves two-parameter Gaussian processes that generalise the standard limit processes involved in cointegrating regressions. Simulations provide evidence of the effectiveness of consistent rank selection by the BIC criterion and the tendency of AIC to overestimate order as in standard lag order selection in autoregression, as well as in reduced rank regression with multiple time series.


Connectivity And Selective Rural Migration, Lin Ma, Yuan Mei, Qunfeng Wu, Mingzhi Xu Aug 2026

Connectivity And Selective Rural Migration, Lin Ma, Yuan Mei, Qunfeng Wu, Mingzhi Xu

Research Collection School Of Economics

How does infrastructure shape rural development? Using household panel data from a nationally representative sample of Chinese villages, matched to high-resolution highway maps, we find that road expansion between 2000 and 2015 operates mainly through reallocation, with less productive farmers scaling down or exiting and more productive farmers remaining and expanding. We quantify the aggregate and distributional consequences in a dynamic spatial equilibrium model with heterogeneous households and endogenous migration. Improved connectivity not only accelerates urbanization but also increases aggregate rural output by 2.2%–5.3% in the long run, even as the rural workforce declines.


Singapore In Global Value Chains: Implications Of The Trump Ii Tariffs, Pao-Li Chang, Ruoqing Chen Aug 2026

Singapore In Global Value Chains: Implications Of The Trump Ii Tariffs, Pao-Li Chang, Ruoqing Chen

Research Collection School Of Economics

This paper examines Singapore’s structural position in global value chains (GVCs) and the implications of the second Trump administration’s tariff escalation for Singapore and the broader ASEAN region. We proceed in three parts. First, using the ADB Multi-Regional Input–Output (MRIO) tables for 2019 and 2024, we characterise Singapore’s GVC participation and position. Singapore is the most GVCintensive economy in ASEAN, with nearly half of its gross exports comprising foreign value-added and a markedly downstream orientation. China is its dominant upstream partner across manufacturing and services—intermediating over 27% of foreign content in electronics and over 10% in chemicals—while Malaysia, Taiwan, and …


Marital Stability And Intrahousehold Inequality, Tomoki Fujii, Xirong Lin, Jacob Penglase Aug 2026

Marital Stability And Intrahousehold Inequality, Tomoki Fujii, Xirong Lin, Jacob Penglase

Research Collection School Of Economics

We study what predicts marital instability using a unique dataset from Japan with detailed measures of spouses’ consumption, savings, labor supply, satisfaction, and marriage-market conditions. We combine descriptive survival and event-study analyses with several econometric and machine-learning approaches, including Cox proportional-hazards models and DynForest, a method designed for survival data with time-varying covariates. Across these approaches, match quality, household resources, time use, stated satisfaction, and marriage-market conditions all contain predictive information. Our main contribution is to show that intrahousehold consumption allocation matters, highlighting information that is missed by standard demographic, time use, and income measures. We relate these findings to …


Laponite Nanosilicate As A Platform For Antigen–Adjuvant Co-Delivery In Vaccination, Haoyu Qi Aug 2026

Laponite Nanosilicate As A Platform For Antigen–Adjuvant Co-Delivery In Vaccination, Haoyu Qi

McKelvey School of Engineering Graduate Student Theses & Dissertations

Nanosilicates are two-dimensional, charged nanomaterials with tunable surface chemistry that enable electrostatic interactions with proteins and nucleic acids. These properties make Laponite nanosilicate a promising platform for vaccine delivery, where coordinated antigen–adjuvant presentation and lymph node delivery are important for shaping immune responses. This thesis investigated nanosilicates as scaffolds for lysozyme-based antigen delivery and co-delivery with CpG.

The preparation method reduced the apparent size of the NS–Lys–CpG complex at pH 10, although neutralization to pH 7 promoted larger aggregate formation. In vivo IVIS imaging after footpad injection showed persistent Cy7-associated fluorescence at the injection site for up to three weeks …


Dissecting Ms4a4a Function In Microglia And Its Role In Alzheimer’S Disease Pathogenesis, Emma Pascal Danhash Aug 2026

Dissecting Ms4a4a Function In Microglia And Its Role In Alzheimer’S Disease Pathogenesis, Emma Pascal Danhash

Arts & Sciences Graduate Student Theses and Dissertations

Genome-wide association studies have begun to uncover the complex genetic architecture of Alzheimer's disease (AD). Expression of many AD risk loci is enriched in microglia, the resident immune cells of the brain. Common variants near the MS4A gene family have been associated with AD risk and altered soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels in the cerebrospinal fluid (CSF). MS4A4A is a microglial gene that encodes a tetraspan membrane protein that regulates anti-inflammatory responses in macrophages. However, the mechanism by which MS4A4A contributes to microglial function and AD pathogenesis remains unknown. In this dissertation, I leveraged a …


Quicknotes August 2026, Southern Adventist University Aug 2026

Quicknotes August 2026, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. The August 2026 edition features Southern alumni serving in Kenya.


“We Want To Make You A Better Man”: African American Men With Dual Membership In Black Greek Letter Organizations And Prince Hall Masonic Lodges, Lakesha Rae Denton Aug 2026

“We Want To Make You A Better Man”: African American Men With Dual Membership In Black Greek Letter Organizations And Prince Hall Masonic Lodges, Lakesha Rae Denton

All-Inclusive List of Electronic Theses and Dissertations

This dissertation examines the rationale and experiences of Black men who have initial membership within a black Greek letter organization as an undergraduate, who also join Masonic Lodges. The study was guided by one research question: 1) what the rationale is pertaining to Black men, who are initially members of Black Greek letter organizations as an undergraduate, that also join a Masonic lodge, therefore granting them dual membership status. The study was important because the value of BGLO’s has declined due to hazing and lack of leadership and guidance. Black men are not being developed as they should and while …


Paperless Society, Paperless Future And Borderless Libraries, Ukoha O. Igwe Aug 2026

Paperless Society, Paperless Future And Borderless Libraries, Ukoha O. Igwe

Library Philosophy and Practice (e-journal)

Purpose: This study explores the indispensability of books and physical libraries despite the digital technologies and digital transformation engulfing our lives, work and society.

Design/Methodology: This study used qualitative design and methodology utilizing a systematic review and synthesis of empirical research, institutional reports and documents published between 1978 and 2025 to achieve its objectives. An extensive review of the pertinent literature was undertaken to underscore the journey and permutations of the death of books and libraries. This conceptual review synthesizes the interplay between digital technologies, digital transformation,and libraries in information dissemination. This provided a basis for inferences and extrapolation of …


The Stories Of College Faculty Navigating Student Trauma Disclosures: A Narrative Inquiry, Samantha Daluz Aug 2026

The Stories Of College Faculty Navigating Student Trauma Disclosures: A Narrative Inquiry, Samantha Daluz

LSU New Orleans Theses and Dissertations

The purpose of this narrative inquiry was to understand how faculty who navigate student trauma disclosures construct stories about themselves as educators and how those stories shape their understanding of teaching and learning. Although the literature has increasingly focused on trauma-informed approaches to teaching and learning, little research has explored how faculty navigate student trauma disclosures or how those experiences shape their understanding of teaching and learning. This study sought to better understand those experiences and provide institutional leaders with insight into how faculty experience student trauma disclosures within higher education. Narrative inquiry was employed using Mahayana Buddhism as the …


Promoting Adolescent Girls’ Mental Health And Resilience In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian Aug 2026

Promoting Adolescent Girls’ Mental Health And Resilience In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian

Adolescents and Young People

The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. This brief emphasizes the importance of adolescent girls’ mental health and resilience in the West and Central African context. It summarizes the evidence on the burden of mental health disorders among adolescent girls, drawing on evidence from the GIRL Center’s priority countries. The brief points to community-based interventions and strategies that have the potential to transform girls’ mental health and resilience.


Intentional Investment In Adolescent Girls In The Digital Space In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian Aug 2026

Intentional Investment In Adolescent Girls In The Digital Space In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian

Adolescents and Young People

The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. This brief summarizes the evidence on which adolescent girls are most excluded from the digital space in West and Central Africa (WCA), drawing on evidence from the GIRL Center’s priority countries. It identifies digital approaches that may be relevant for adolescent girls in the West and Central African context, while recognizing that rigorous evidence remains limited, especially in francophone and fragile settings.


Accelerating Progress For Adolescent Girls In Humanitarian Settings In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian Aug 2026

Accelerating Progress For Adolescent Girls In Humanitarian Settings In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian

Adolescents and Young People

The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. This brief summarizes the evidence on what humanitarian crises mean for girls’ immediate safety, continuity of services, and longer-term life chances in West and Central Africa (WCA), particularly evidence from the GIRL Center’s priority countries. This brief summarizes the evidence on what humanitarian crises mean for girls’ immediate safety, continuity of services, and longer-term life chances. The brief informs strategies that have the potential to enhance protection, resilience, and development in …


Accélérer L’Éducation Des Adolescentes En Afrique De L’Ouest Et Du Centre, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian Aug 2026

Accélérer L’Éducation Des Adolescentes En Afrique De L’Ouest Et Du Centre, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian

Adolescents and Young People

La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels font face les adolescentes de la région et met en lumière des approches éclairées par les données probantes pour améliorer leurs conditions de vie. Cette note présente les données disponibles sur les inégalités entre les sexes dans l’éducation en Afrique de l’Ouest et du Centre (AOC), avec une attention particulière aux pays prioritaires du GIRL Center. Elle analyse la fréquentation scolaire, la progression des apprentissages, le passage au secondaire et la réintégration scolaire. Elle vise à …


Climate Change And Adolescent Girls In West And Central Africa: Building A Girl-Intentional Response, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian Aug 2026

Climate Change And Adolescent Girls In West And Central Africa: Building A Girl-Intentional Response, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian

Adolescents and Young People

The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. This brief summarizes the evidence on how climate shocks reshape the lives of adolescent girls in West and Central Africa, drawing in particular on evidence from the GIRL Center’s priority countries. It examines gendered climate vulnerabilities, gaps in climate policies that overlook girls, and emerging adaptation strategies that hold promise for girls in the region. The brief points to what a girl-intentional climate response could look like across the priority countries.


Defining The Value Of Elective Lumbar Fusion: A Systematic Review Of Existing Methodologies And Framework For The Operative Value Index, Advith Sarikonda, Anthony Chen, Theo S. Biddle, Danyal A. Quraishi, Preston Carey, Arbaz A. Momin, Matthews Lan, Dwight Mitchell Self, Ashmal S. Kabani, Ahilan Sivaganesan Aug 2026

Defining The Value Of Elective Lumbar Fusion: A Systematic Review Of Existing Methodologies And Framework For The Operative Value Index, Advith Sarikonda, Anthony Chen, Theo S. Biddle, Danyal A. Quraishi, Preston Carey, Arbaz A. Momin, Matthews Lan, Dwight Mitchell Self, Ashmal S. Kabani, Ahilan Sivaganesan

Department of Neurosurgery Faculty Papers

BACKGROUND: Despite wide variation in the outcomes and costs of lumbar fusion, few studies have integrated these domains together within a single metric to assess "value" (outcomes achieved per dollar spent). In this review, we sought to 1) characterize existing metrics of cost-effectiveness for lumbar fusion, 2) evaluate all applications of time-driven activity-based costing (TDABC) in spine surgery, and 3) outline the conceptual foundation for a standardized Operative Value Index (OVI).

METHODS: Two PRISMA-concordant systematic reviews were performed on PubMed and Scopus databases. The first review examined all studies which reported a cost-effectiveness metric for lumbar fusion. The second review …


The Joint Effect Of Bilingualism And Sleep On Executive Functions Among Children And Adolescents With Attention Deficit/Hyperactivity Disorder (Adhd), Yirou Jiang Aug 2026

The Joint Effect Of Bilingualism And Sleep On Executive Functions Among Children And Adolescents With Attention Deficit/Hyperactivity Disorder (Adhd), Yirou Jiang

Doctoral Dissertations

Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that significantly impacts cognitive and behavioral functions, leading challenges for individuals across the lifespan. While extensive research has been conducted to understand the connection between executive functioning (EF) and ADHD, research findings related to the contributing factors of bilingualism and sleep still remains inconsistent (Bialystok et al., 2017). Investigating the joint effect between bilingualism and sleep on EF among children and adolescents with ADHD may help further clarify the connection between EF, language, and sleep, and facilitate the development of interventions from the perspective of these protective factors. EF encompasses cognitive processes …


Passive House Envelope Retrofit For Heritage Buildings In Hot Semi-Arid Climates: A Shoebox Energy Simulation Study Of The Former British Residency (Osmania University College For Women), Hyderabad, India, Hasini Kadaru Aug 2026

Passive House Envelope Retrofit For Heritage Buildings In Hot Semi-Arid Climates: A Shoebox Energy Simulation Study Of The Former British Residency (Osmania University College For Women), Hyderabad, India, Hasini Kadaru

Theses

This study assesses interior-oriented envelope retrofits based on Passive House principles, applied to the British Residency of Hyderabad, now called Telangana Mahila Viswa Vidyalayam since 2022, and to Osmania University College for Women (OUCW) for the prior 70 years. This Grade 1-listed building was constructed in several phases starting in the 1790s, then remodeled and extended under Resident James Achilles Kirkpatrick from 1798 to 1805 and completed around 1808. It served as the Residency until 1947, when it was handed over to Osmania University.    Due to the conservation approach applied to the site, which does not allow any external changes, …


The Fall Of King Arthur Of Britain In Giovanni Boccaccio’S On The Downfall Of The Famous, Christopher Berard, Morris Tichenor Aug 2026

The Fall Of King Arthur Of Britain In Giovanni Boccaccio’S On The Downfall Of The Famous, Christopher Berard, Morris Tichenor

Humanities Program Faculty Publications

Giovanni Boccaccio (1313–75), born in Certaldo, Tuscany, is one of the tre corone (Three Crowns) of Italian Literature. He shares this distinction with Dante Alighieri (1265–1321), about whose life and literary works he wrote treatises and delivered lectures, and Francesco Petrarch (1304–74), with whom he formed a lasting friendship (beginning in 1350). All three wrote widely acclaimed literature in the Florentine-Tuscan dialect of Italian, enabling it to become the basis for standard Italian. In addition to elevating the Italian vernacular as a literary language, they prioritized Classical Studies and were forerunners of the Italian humanist movement (c.1400–1600). Today, Boccaccio is …


Extending Genome-Wide Association Studies To Admixed Cohorts With High Degrees Of Relatedness, Taotao Tan, Alejandra Vergara-Lope, José Jaime Martínez-Magaña, Nirav N Shah, Yi-Sian Lin, Kai Yuan, Jaime Berumen, Jesus Alegre-Díaz, Pablo Kuri-Morales, Roberto Tapia-Conyer, Joel Gelenter, Janitza L Montalvo-Ortiz, Wei Zhou, Jason M Torres, Elizabeth G Atkinson Aug 2026

Extending Genome-Wide Association Studies To Admixed Cohorts With High Degrees Of Relatedness, Taotao Tan, Alejandra Vergara-Lope, José Jaime Martínez-Magaña, Nirav N Shah, Yi-Sian Lin, Kai Yuan, Jaime Berumen, Jesus Alegre-Díaz, Pablo Kuri-Morales, Roberto Tapia-Conyer, Joel Gelenter, Janitza L Montalvo-Ortiz, Wei Zhou, Jason M Torres, Elizabeth G Atkinson

Duncan NRI Faculty and Staff Publications

Admixed populations comprise a large portion of the human population worldwide, but are often excluded from genome-wide association studies (GWASs) due to analytic challenges. Our group developed Tractor, a local-ancestry-informed GWAS tool designed for admixed samples that produces accurate ancestry-specific effect sizes and boosts the discovery power to identify ancestry-enriched loci. However, Tractor operates under an assumption of unrelated samples. Here, to address this gap, we propose Tractor-Mix, which allows for well-calibrated association studies in datasets containing admixed samples with relatedness. Extensive simulations show that this method is competitive with other state-of-the-art approaches that do not produce ancestry-specific results. Empirical …


A Blended Genome And Exome Sequencing Method Captures Genetic Variation In An Unbiased And Cost-Effective Manner, Toni A Boltz, Benjamin B Chu, Matthew Defelice, Calwing Liao, Julia M Sealock, Robert Ye, Jacqueline I Goldstein, Lerato Majara, Jack M Fu, Susan K Service, Lingyu Zhan, Sarah E Medland, Sinéad B Chapman, Simone Rubinacci, Jonna L Grimsby, Tamrat Abebe, Melkam Alemayehu, Fred K Ashaba, Elizabeth G Atkinson, Tim B Bigdeli, Amanda B Bradway, Harrison Brand, Lori B Chibnik, Samuel Deluca, Ana M Diaz-Zuluaga, Abebaw Fekadu, Michael Gatzen, Bizu Gelaye, Stella Gichuru, Marissa L Gildea, Toni C Hill, Hailiang Huang, Kalyn M Hubbard, Wilfred E Injera, Roxanne James, Moses Joloba, Christopher Kachulis, Phillip R Kalmbach, Rogers Kamulegeya, Gabriel Kigen, Soyeon Kim, Nastassja Koen, Edith K Kwobah, Joseph Kyebuzibwa, Seungmo Lee, Niall J Lennon, Penelope A Lind, Esteban A Lopera-Maya, Johnstone Makale, Serghei Mangul, Justin Mcmahon, Pierre Mowlem, Henry Musinguzi, Rehema M Mwema, Noeline Nakasujja, Carter P Newman, Lethukuthula L Nkambule, Conor R O'Neil, Ana Maria Olivares, Catherine M Olsen, Linnet Ongeri, Sophie J Parsa, Adele Pretorius, Shengying Qin, Raj Ramesar, Faye L Reagan, Chiara Sabatti, Jacquelyn A Schneider, Welelta Shiferaw, Christine Stevens, Anne Stevenson, Erik Stricker, Rocky E Stroud, Jessie Tang, Megan Townsend, David Whiteman, Mary T Yohannes, Mingrui Yu, Kai Yuan, Dickens Akena, Lukoye Atwoli, Symon M Kariuki, Karestan C Koenen, Charles R J C Newton, Dan J Stein, Solomon Teferra, Zukiswa Zingela, Carlos N Pato, Michele T Pato, Carlos Lopez-Jaramillo, Nelson B Freimer, Roel A Ophoff, Loes M Olde Loohuis, Michael E Talkowski, Benjamin M Neale, Daniel P Howrigan, Alicia R Martin Aug 2026

A Blended Genome And Exome Sequencing Method Captures Genetic Variation In An Unbiased And Cost-Effective Manner, Toni A Boltz, Benjamin B Chu, Matthew Defelice, Calwing Liao, Julia M Sealock, Robert Ye, Jacqueline I Goldstein, Lerato Majara, Jack M Fu, Susan K Service, Lingyu Zhan, Sarah E Medland, Sinéad B Chapman, Simone Rubinacci, Jonna L Grimsby, Tamrat Abebe, Melkam Alemayehu, Fred K Ashaba, Elizabeth G Atkinson, Tim B Bigdeli, Amanda B Bradway, Harrison Brand, Lori B Chibnik, Samuel Deluca, Ana M Diaz-Zuluaga, Abebaw Fekadu, Michael Gatzen, Bizu Gelaye, Stella Gichuru, Marissa L Gildea, Toni C Hill, Hailiang Huang, Kalyn M Hubbard, Wilfred E Injera, Roxanne James, Moses Joloba, Christopher Kachulis, Phillip R Kalmbach, Rogers Kamulegeya, Gabriel Kigen, Soyeon Kim, Nastassja Koen, Edith K Kwobah, Joseph Kyebuzibwa, Seungmo Lee, Niall J Lennon, Penelope A Lind, Esteban A Lopera-Maya, Johnstone Makale, Serghei Mangul, Justin Mcmahon, Pierre Mowlem, Henry Musinguzi, Rehema M Mwema, Noeline Nakasujja, Carter P Newman, Lethukuthula L Nkambule, Conor R O'Neil, Ana Maria Olivares, Catherine M Olsen, Linnet Ongeri, Sophie J Parsa, Adele Pretorius, Shengying Qin, Raj Ramesar, Faye L Reagan, Chiara Sabatti, Jacquelyn A Schneider, Welelta Shiferaw, Christine Stevens, Anne Stevenson, Erik Stricker, Rocky E Stroud, Jessie Tang, Megan Townsend, David Whiteman, Mary T Yohannes, Mingrui Yu, Kai Yuan, Dickens Akena, Lukoye Atwoli, Symon M Kariuki, Karestan C Koenen, Charles R J C Newton, Dan J Stein, Solomon Teferra, Zukiswa Zingela, Carlos N Pato, Michele T Pato, Carlos Lopez-Jaramillo, Nelson B Freimer, Roel A Ophoff, Loes M Olde Loohuis, Michael E Talkowski, Benjamin M Neale, Daniel P Howrigan, Alicia R Martin

Duncan NRI Faculty and Staff Publications

Here we developed and deployed the blended genome exome (BGE) method, a DNA library approach that generates low-pass whole-genome (1–4× mean depth) and deep whole-exome (30–40× mean depth) data in a single sequencing run. BGE is cost-effective, empowers most genomic discoveries possible with deep whole-genome sequencing and captures global common single-nucleotide polymorphism diversity. We applied BGE to sequence >53,000 samples from the PUMAS Project (Populations Underrepresented in Mental Illness Associations Studies), including African, African American and Latin American populations. Imputed genotypes showed high concordance with Illumina Global Screening Array calls (R2 ≥ 95% for minor allele frequency ≥1%; …