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Articles 34411 - 34440 of 1439357
Full-Text Articles in Entire DC Network
Using Visual Imagery To Manipulate Recognition Memory For Faces Whose Appearance Has Changed, Michelle M. Ramey, Darya L. Zabelina
Using Visual Imagery To Manipulate Recognition Memory For Faces Whose Appearance Has Changed, Michelle M. Ramey, Darya L. Zabelina
Psychological Science Faculty Publications and Presentations
Real-world recognition requires our memory system to accommodate perceptual changes that occur after encoding; for example, eyewitnesses must recognize perpetrators across changes in appearance. However, it is not clear how this flexible recognition ability can be improved: Standard encoding strategies not only tend to be ineffective,but can in fact be detrimental for recognizing people across appearance changes. Given the effectiveness of visual imagery in creating and modifying memory representations, we examined whether counterfactual visual imagery could be used to manipulate flexible recognition by simulating an increase in encoding-retrieval similarity. Across two experiments, participants (n = 317) encoded faces with neutral …
What Kinds Of Experiences And Activities Contribute To College Students' Sense Of Purpose? A Mixed-Methods Study, Katlyn Rochelle Viers
What Kinds Of Experiences And Activities Contribute To College Students' Sense Of Purpose? A Mixed-Methods Study, Katlyn Rochelle Viers
Dissertations and Theses
For many young people, attending college is a core marker of the transition to emerging adulthood. Some students thrive in college while others become lost, confused, or seem to be just marking their time. Some researchers have hypothesized that one thing that can help students take advantage of their college experience is if they are firmly anchored in their own life goals and sense of purpose. The primary goal of this study is to contribute to knowledge about the role of a sense of purpose in college students' development, including not only its potential benefits to their academic functioning and …
From Either-Or To All Together: Integrating Universal And Relativistic Approaches To Belonging And Engagement In The First Year Of Middle School, Kristina Shiann Tucker
From Either-Or To All Together: Integrating Universal And Relativistic Approaches To Belonging And Engagement In The First Year Of Middle School, Kristina Shiann Tucker
Dissertations and Theses
Schools are designed to foster growth and learning while promoting positive educational outcomes for all students. Yet, there is some evidence that the education system is not meeting the needs of all students, nor are achievement outcomes the same for everyone. Some of the identified challenges seem to be developmentally based, whereas others are evident among different demographic subgroups. Developmental differences are apparent in many aspects of academic functioning, such as student motivation and engagement, which peak when students enter school and normatively decline, relatively steadily, throughout students' educational careers. Demographic disparities are even more pronounced, represented, for example, in …
Public K-12 School Start Times In The Mountain West, 2020-2021, Olivia K. Cheche, William E. Brown Jr.
Public K-12 School Start Times In The Mountain West, 2020-2021, Olivia K. Cheche, William E. Brown Jr.
K-12 Education
This fact sheet presents data on public K-12 school start times in the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah as of the 2020-2021 school year. The data are derived from the “School start time: Average public K–12 school start time and percentage distribution of public school start time, by state: 2020–21” report originally published by the National Center for Education Statistics (NCES). This fact sheet highlights the average public K-12 school start times and distribution of public K-12 school start times for each Mountain West state.
Multispectral Image Analysis Using Deep Neural Networks, Arun D. Kulkarni
Multispectral Image Analysis Using Deep Neural Networks, Arun D. Kulkarni
Computer Science Faculty Publications and Presentations
Multispectral image classification plays a crucial role in remote sensing applications such as land cover mapping, agricultural monitoring, and environmental surveillance. Traditional classification techniques, including the Maximum Likelihood Classifier (MLC), Support Vector Machine (SVM), Decision Tree (DT), and Multi-Layer Perceptron (MLP), often struggle with the complexity and high dimensionality of multispectral data. Recent advances in deep learning have revolutionized the field of remote sensing by enabling the extraction of high-level, abstract features from raw input data. In this paper, we explore the application of Deep Neural Networks (DNNs) for pixel-wise classification in multispectral imagery. DNNs are capable of learning informative …
Quality Improvement Project Providing Accessible Evidence-Based Education To Nurses Throughout A National Healthcare System, Bailey Wells
Quality Improvement Project Providing Accessible Evidence-Based Education To Nurses Throughout A National Healthcare System, Bailey Wells
Doctor of Nursing Practice Projects
The pursuit of ongoing professional development and learning is crucial to ensure nurses remain well-informed about healthcare trends and have access to the most up-to-date evidence-based materials. This quality improvement project aimed to implement a monthly educational series for nursing personnel within the Veterans Health Administration (VHA) through expansion of the Veterans Administration (VA) – Extension for Community Healthcare Outcomes (ECHO) program. Using Bandura’s Self-Efficacy Theory of Motivation in Psychology, participants’ previous knowledge was linked to continued professional development. The plan, do, study, act (PDSA) framework provided structure for the project, with the awareness, desire, knowledge, ability, and reinforcement (ADKAR) …
The Impact Of The Guided Discovery Method Combined With Sequential Learning On Selected Artistic Gymnastics Skills Among University Students, Ali Shakir Neamah
The Impact Of The Guided Discovery Method Combined With Sequential Learning On Selected Artistic Gymnastics Skills Among University Students, Ali Shakir Neamah
Modern Sport
This study aims to examine the impact of employing the guided discovery method as the primary approach in teaching certain gymnastics skills, with the sequential method serving as a supportive tool to organize and structure the learning stages. which emphasized the combination of both methods so as to achieve both cognitive and motor objectives for the students. The importance of the current article lies on the emphasizing the duty of guided discovery to develop students’ analytical skills and thinking and motivate the learners to participate actively in the process of learning. Moreover, it contributes to develop motor skill through the …
Navigating Succession: Exploring Succession Planning Strategies In Polish Family Businesses, Jan M. Klaczak, Theresa M. Neal, Yvonne Doll
Navigating Succession: Exploring Succession Planning Strategies In Polish Family Businesses, Jan M. Klaczak, Theresa M. Neal, Yvonne Doll
International Journal of Applied Management and Technology
Family businesses are the foundation of modern economies and societies, yet many encounter continuity challenges during succession. The purpose of this qualitative, multiple-case study grounded in Rothwell’s seven-step model for succession planning was to explore succession planning strategies Polish family business leaders used for ownership and leadership transfer to the next generation. Three family business leaders who executed succession planning in their firms participated in the study. Data were collected via semistructured interviews, researcher notes, and company document reviews. Using methodological triangulation and Yin’s five-step data analysis, four themes emerged: systematic succession, grooming the successor, communication with nonfamily stakeholders, and …
Rising Waters, Falling Taxes: The Impact Of Hurricane Sandy On Property Tax Assessments In New York City, Wei Guo, Qing Miao, Yusun Kim, Yilin Hou
Rising Waters, Falling Taxes: The Impact Of Hurricane Sandy On Property Tax Assessments In New York City, Wei Guo, Qing Miao, Yusun Kim, Yilin Hou
Center for Policy Research
Climate disasters pose fiscal challenges for local governments by increasing recovery costs and demand for property tax relief. Homeowners with or without property damage face tax burdens that may not match changes to their property value. This study examines the impact of Hurricane Sandy on property values and tax assessments in New York City. Using a difference-in-differences approach and comprehensive property-level data, we find that (1) inundated properties faced greater tax burdens due to limited declines in taxable value; (2) unaffected properties in flood zones saw tax burden increases due to declining market values and unchanged taxable values; and (3) …
Conference Proceedings: Select Abstracts Presented At The 2025 Advocate Aurora Scientific Day, Advocate Aurora Scientific Day
Conference Proceedings: Select Abstracts Presented At The 2025 Advocate Aurora Scientific Day, Advocate Aurora Scientific Day
Journal of Patient-Centered Research and Reviews
This abstract supplement includes findings presented through oral or poster presentations at the 51st annual Scientific Day event held on May 21, 2025. Scientific Day provides both an in-person and virtual forum for the sharing of research, quality improvement, and case studies conducted by Illinois- and Wisconsin-based faculty, fellows, residents, and other health professionals associated with Advocate Health.
Htlv-1 And Atll: Epidemiology, Oncogenesis, And Opportunities For Community-Informed Research In The United States, Adrian D. Altieri, Sean P. Reilly, Abu Mansalay, Alan Khoo, Nettie Johnson, Zafar K. Khan, Amy Leader, Pooja Jain, Pierluigi Porcu
Htlv-1 And Atll: Epidemiology, Oncogenesis, And Opportunities For Community-Informed Research In The United States, Adrian D. Altieri, Sean P. Reilly, Abu Mansalay, Alan Khoo, Nettie Johnson, Zafar K. Khan, Amy Leader, Pooja Jain, Pierluigi Porcu
Kimmel Cancer Center Faculty Papers
Human T-cell leukemia virus type 1 (HTLV-1), the first oncogenic human retrovirus, causes adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm of mature CD4+ T-cells that is incurable in most patients and is associated with a median survival of less than 1 year. HTLV-1 also causes inflammatory disorders, including HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and uveitis. The estimated lifetime risks of ATLL and HAM/TSP in HTLV-1 carriers are 3-5% and 0.25-1.8%, respectively. Although there is uncertainty about other health effects of HTLV-1, a recent meta-analysis showed an association between HTLV-1 and cardiovascular, cerebrovascular, and metabolic diseases and a 57% increased risk …
Ketorolac Use Following Operative Clavicle Fracture Fixation Is Not Associated With Increased Nonunion Or Surgical Complications: A Propensity-Matched Analysis, Tuckerman Jones, Tej Joshi, Akhil Katakam, Daniella Ogilvie, Sefy Paulose, Balazs Galdi
Ketorolac Use Following Operative Clavicle Fracture Fixation Is Not Associated With Increased Nonunion Or Surgical Complications: A Propensity-Matched Analysis, Tuckerman Jones, Tej Joshi, Akhil Katakam, Daniella Ogilvie, Sefy Paulose, Balazs Galdi
Wills Eye Hospital Papers
OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, are commonly used for postoperative pain management. Concerns about their potential impact on bone healing have been raised. This study investigated the relationship between ketorolac use and postoperative complications following clavicle surgery, including nonunion rates.
METHODS: This retrospective cohort study used the TriNetX Research Database to identify patients who underwent surgical fixation of clavicle fractures between 2002 and 2022. Two propensity-matched cohorts were created: patients who received postoperative ketorolac and those who did not. Primary outcomes included nonunion diagnosis and revision surgery; secondary outcomes included opioid use, wound disruption, surgical site infection, and …
Charting Truth, Trust, And Transformers: A Critical Look At Ai Text Detection And Recommendations For Medical Journals, Hari Mudipalli, Mahtab Milburn, Souritya Saha, Jamie Fairclough
Charting Truth, Trust, And Transformers: A Critical Look At Ai Text Detection And Recommendations For Medical Journals, Hari Mudipalli, Mahtab Milburn, Souritya Saha, Jamie Fairclough
Journal of Patient-Centered Research and Reviews
This editorial provides an overview of large language models (LLMs), the risks associated with their use, and the challenges involved in using artificial intelligence (AI) to determine the extent to which LLMs have been used to write text, including articles for publication in medical journals. As narratives generated by LLMs become increasingly difficult to distinguish from human writing, concerns have emerged about their impact on scholarly communication, particularly in health and medicine. The medical community is becoming more aware of various tools that can detect AI-generated text; however, adopting these tools comes with unique challenges. The purpose of this article …
Perspectives On Communicating Information And Shared Decision-Making In Patients Undergoing Transtibial Amputation, Lina Walther Sjödin, Lasse J. Lapidus, Eva Torbjörnsson
Perspectives On Communicating Information And Shared Decision-Making In Patients Undergoing Transtibial Amputation, Lina Walther Sjödin, Lasse J. Lapidus, Eva Torbjörnsson
Journal of Patient-Centered Research and Reviews
Purpose: Patients undergoing lower extremity amputation often desire to take an active part in decision-making. The primary aim of this study was to explore patients’ experiences of the care trajectory and information provided after a new care program was introduced. The secondary aim was to explore patients' perspectives of their involvement and participation in shared decision-making throughout the care process. The care program features new educational material, recommendations for the sagittal surgical technique, and information about a rigid removable dressing, early liner treatment, and a multidisciplinary team follow up three weeks after amputation.
Methods: Fifteen participants who underwent transtibial amputation …
Queering The Classrooms: Filipino Teachers’ Perspectives And Practices Of Queer Pedagogy, Holden Kenneth G. Alcazaren, Jonalou S. Labor
Queering The Classrooms: Filipino Teachers’ Perspectives And Practices Of Queer Pedagogy, Holden Kenneth G. Alcazaren, Jonalou S. Labor
Asia-Pacific Social Science Review
With the increasing progress of queer perspectives in the academic setting, there have been calls for LGBTQ+-inclusive teaching practices. In the Philippines, attempts have been implemented to produce curricula and materials that are more gender-responsive and gender-sensitive. However, these initiatives are without their barriers as conservative traditions and sexist ideologies still affect the eradication of gender-based discrimination in the classrooms. To fully grasp these issues, the present study aimed to elicit insights from queer Filipino teachers about their views and perspectives on using queer pedagogy in their classrooms. With these pedagogical choices, the study tried to understand the queering process …
Executive Committee - Agenda, 09/30/2025, Academic Senate
Executive Committee - Agenda, 09/30/2025, Academic Senate
Academic Senate Agendas
No abstract provided.
Granite Staters Worried About Political Violence, Mass Shootings; Trump Approval Continues To Slide 9/30/2025, Unh Survey Center
Granite Staters Worried About Political Violence, Mass Shootings; Trump Approval Continues To Slide 9/30/2025, Unh Survey Center
All UNH Survey Center Polls
Three-quarters of New Hampshire residents say they are worried about political violence, while two-thirds are concerned about mass shootings. A majority in the Granite State oppose President Trump's deployment of the National Guard to American cities and few would feel safer if soldiers were deployed to cities in New Hampshire. Approval of Trump's handling of foreign policy, the economy, and his overall job have declined since August, and approval of his handling of the economy is at its lowest point in either of Trump's terms. Just over one-third of state residents approve of Health and Human Services Secretary Robert F. …
Trump Approval Low In Rhode Island; Many Fear Mass Shootings And Political Violence 9/30/2025, Unh Survey Center
Trump Approval Low In Rhode Island; Many Fear Mass Shootings And Political Violence 9/30/2025, Unh Survey Center
All UNH Survey Center Polls
President Trump’s approval rating remains low as Rhode Islanders disapprove of his use of the National Guard in American cities and have increased fears of political violence. A majority also disapprove of Trump’s handling of the economy and disapprove of his actions directed at the Federal Reserve. Less than one-third of Rhode Islanders approve of Health and Human Services Secretary Robert F. Kennedy Jr.'s handling of his job.
Approval Of Trump Remains Low In Connecticut Amid Worries Over Political Violence, Mass Shootings 9/30/2025, Unh Survey Center
Approval Of Trump Remains Low In Connecticut Amid Worries Over Political Violence, Mass Shootings 9/30/2025, Unh Survey Center
All UNH Survey Center Polls
Approval of President Donald Trump's job performance remains low in Connecticut, although nearly all Republicans approve. More than two-thirds of Connecticut residents are very or somewhat worried about political violence and mass shootings harming them or their family, while a majority are also worried about a foreign terrorist attack. A majority feel the federal government is not justified in sending the National Guard to American cities, and a plurality would feel less safe if the National Guard or other soldiers were deployed to cities in Connecticut. One-third of state residents approve of Health and Human Services Secretary Robert F. Kennedy …
Becoming-With Teachers: An Auto-Theoretical Reading Of Reflective Texts, Le Thanh Thao, Pham Trut Thuy
Becoming-With Teachers: An Auto-Theoretical Reading Of Reflective Texts, Le Thanh Thao, Pham Trut Thuy
The Qualitative Report
This article reimagines teacher reflection not as data to be analyzed, but as a relational and affective space to be inhabited. Drawing on the principles of auto-theory and post-qualitative inquiry, we approach a familiar dataset of Vietnamese English as a foreign language (EFL) teacher reflection through a method of writing-with, responding not through interpretation, but through resonance, hesitation, and companionship. Rather than coding or categorizing the texts, we lingered with their silences, rhythms, and rhetorical composure. What emerged was not a framework but a cartography: a radial constellation of five interwoven stances, including permission, composure, relational imprint, echoing, and unknowing. …
Public Housing Film Series, The Lender Center For Social Justice, Cornell University
Public Housing Film Series, The Lender Center For Social Justice, Cornell University
The Lender Center for Social Justice
A poster for the three-part Public Housing Film Series
Market-Economic Decentralization And Governance In Hargeisa Local Government, Somaliland, Mustafe Mahamoud Abdillahi, Bella Oluka Benjamin
Market-Economic Decentralization And Governance In Hargeisa Local Government, Somaliland, Mustafe Mahamoud Abdillahi, Bella Oluka Benjamin
BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi
This study investigates the relationship between market-economic decentralization and governance within the Hargeisa Local Government in Somaliland. Market-economic decentralization, influenced by neoliberal principles, involves transferring decision-making authority to local levels to stimulate private sector engagement and economic efficiency. Despite comprehensive decentralization reforms initiated in 2001, Hargeisa continues to confront significant governance challenges, including institutional weaknesses, fiscal mismanagement, and corruption. Employing a mixed-methods approach, this research integrates quantitative surveys and qualitative interviews with 269 local officials to assess the impact of decentralization on key governance indicators: accountability, transparency, and e-governance. The results demonstrate strong positive correlations between market-economic decentralization and improved …
Improving Data-Driven Gated (Ddg) Pet And Ct Registration In Thoracic Lesions: A Comparison Of Ai Registration And Ddg Ct, Tinsu Pan, M Allan Thomas, Yang Lu, Dershan Luo
Improving Data-Driven Gated (Ddg) Pet And Ct Registration In Thoracic Lesions: A Comparison Of Ai Registration And Ddg Ct, Tinsu Pan, M Allan Thomas, Yang Lu, Dershan Luo
Faculty, Staff and Student Publications
Purpose: Misregistration between CT and PET can result in mis-localization and inaccurate quantification of the tracer uptake in PET. Data-driven gated (DDG) CT can correct registration and quantification but requires a radiation dose of 1.3 mSv and 1 min of acquisition time. AI registration (AIR) does not require an additional CT and has been validated to improve registration and reduce the 'banana' misregistration artifacts around the diaphragm. We aimed to compare a validated AIR and DDG CT in registration and quantification of avid thoracic lesions misregistered in DDG PET scans.
Methods: Thirty PET/CT patient data (23 with 18F-FDG, 4 with …
Bay Staters Reject National Guard In Cities, Would Feel Less Safe If Guard Sent To Massachusetts 9/30/2025, Unh Survey Center
Bay Staters Reject National Guard In Cities, Would Feel Less Safe If Guard Sent To Massachusetts 9/30/2025, Unh Survey Center
All UNH Survey Center Polls
Massachusetts residents think sending the National Guard to American cities is not justified, and more than half would feel less safe if the Guard or other soldiers were deployed to cities in Massachusetts. More than two-thirds of state residents are worried about being victimized by political violence or mass shootings. Six in ten disapprove of President Trump's job performance and two-thirds disapprove of Health and Human Services Secretary Robert F. Kennedy Jr.'s handling of his job.
Durable Low-Friction Graphite Coatings Enabled By A Polydopamine Adhesive Underlayer, Adedoyin Ayomide Abe, Fernando Maia De Oliveira, Deborah Okyere, Mourad Benamara, Jingyi Chen, Yuriy I. Mazur, Min Zou
Durable Low-Friction Graphite Coatings Enabled By A Polydopamine Adhesive Underlayer, Adedoyin Ayomide Abe, Fernando Maia De Oliveira, Deborah Okyere, Mourad Benamara, Jingyi Chen, Yuriy I. Mazur, Min Zou
Mechanical Engineering Faculty Publications and Presentations
This study investigates the tribological performance and wear mechanisms of graphite and polydopamine/graphite (PDA/graphite) coatings on stainless steel under dry sliding conditions. While graphite is widely used as a solid lubricant, its poor adhesion to metal substrates limits long-term durability. Incorporating an adhesion-promoting PDA underlayer significantly improved coating lifetime and wear resistance. Tribological testing revealed that PDA/graphite coatings maintained a coefficient of friction (COF) below 0.15 for over seven times longer than graphite-only coatings. High-resolution scanning electron microscopy, SEM, and profilometry showed that PDA improved coating adhesion and suppressed lateral debris transport, confining wear to a narrow zone. Surface and …
Mcmc-Net: Accelerating Markov Chain Monte Carlo With Neural Networks For Inverse Problems, Anuj Abhishek
Mcmc-Net: Accelerating Markov Chain Monte Carlo With Neural Networks For Inverse Problems, Anuj Abhishek
Faculty Scholarship
In many computational problems, using the Markov Chain Monte Carlo (MCMC) can be prohibitively time-consuming. We propose MCMC-Net, a simple yet efficient way to accelerate MCMC via neural networks. The key idea of our approach is to substitute the true likelihood function of the MCMC method with a neural operator based surrogate. We extensively evaluate the accuracy and speedup of our method on three different partial differential equation-based inverse problems where likelihood computations are computationally expensive, namely electrical impedance tomography, diffuse optical tomography, and quantitative photoacoustic tomography. MCMC-Net performs similar to the classical likelihood counterpart but with a significant speedup. …
Examining Filipino Cultural Traits And Entrepreneurial Intention: Applying The Mapa Ng Loob Framework Within The Five-Factor Model In Academic Entrepreneurship, Marlo C. Novino
Asia-Pacific Social Science Review
The academic community is transitioning to fulfill its new mission of promoting innovation and entrepreneurship for economic and social development. With this, there is a need to examine the entrepreneurial intention of an academic entrepreneur from a cultural trait lens. This study explores lexically based Filipino personality traits that influence entrepreneurial attitude and intention in an academic setting, highlighting the significance of the Masaklaw na Panukat ng Loob (Mapa ng Loob) psychological tool as a culturally relevant framework. The Mapa ng Loob thoroughly evaluates personality trait constructs that are both theoretically and practically important in Filipino culture by providing a …
Criminal Records As Political Capital: Renegotiating Ex-Convict Labels To Acquire Village Head Positions In East Java, Indonesia, Mochamad Iqbal Jatmiko, Muhamad Supraja
Criminal Records As Political Capital: Renegotiating Ex-Convict Labels To Acquire Village Head Positions In East Java, Indonesia, Mochamad Iqbal Jatmiko, Muhamad Supraja
Asia-Pacific Social Science Review
Unlike other new democracies, the political system in post-authoritarian Indonesia has recently allowed ex-convicts to run for election. This qualitative case study examines how ex-prisoners serving as village heads in Probolinggo Regency, East Java, discursively reframed their criminal past as informal symbolic capital to win rural political contestations and effectively execute village bureaucratic functions. Contrary to previous analyses highlighting collateral consequences that disqualify ex-criminals’ political prospects, we report that interactive dialogue has successfully turned negative reputations into collectively consented territorial patronage, specifically within crime-prone village contexts. Through persuasive discursive means, this can then be leveraged to mobilize voters’ political support …
The Role Of Strategic Alignment In Achieving Sustainable Competitive Advantage-An Analytical Study At Al-Maaref University College, Ali Ahmed Mohammed
The Role Of Strategic Alignment In Achieving Sustainable Competitive Advantage-An Analytical Study At Al-Maaref University College, Ali Ahmed Mohammed
Muthanna Journal of Administrative and Economics Sciences
This study aims to determine the role of strategic alignment as an independent variable and its correlation with sustainable competitive advantage as a dependent variable at Al-Maarif University College. The researcher employed a descriptive-analytical methodology, which comprised a cohort of faculty members from the college, with a sample size of 72 respondents. The researcher employed a questionnaire as the primary instrument for data collection, utilising the statistical software (SPSS) in conjunction with (Excel) for data analysis. Research has demonstrated a direct correlation and beneficial effect of strategic alignment in its dimensions (communication, value, governance, partnership, infrastructure, skills) on sustainable competitive …
Design And Application Of A Tau Seed Amplification Assay For Screening Inhibitors Of Tau Seeding, Damian Gorski, Haley Evans, Tyler Allison, Carla Barria, Danielle Harrison, Victor Banerjee, Nicolas Mendez, Mohammad Shahnawaz, Sanne Kaalund, Jonas Folke, Susana Aznar, Paul Schultz, Fei Wang, Claudio Soto
Design And Application Of A Tau Seed Amplification Assay For Screening Inhibitors Of Tau Seeding, Damian Gorski, Haley Evans, Tyler Allison, Carla Barria, Danielle Harrison, Victor Banerjee, Nicolas Mendez, Mohammad Shahnawaz, Sanne Kaalund, Jonas Folke, Susana Aznar, Paul Schultz, Fei Wang, Claudio Soto
Faculty, Staff and Student Publications
Background: Tau protein aggregates are a key pathological hallmark of Alzheimer's disease (AD) and are closely associated with cognitive decline and neurodegeneration. It is proposed that tau aggregates faithfully propagate throughout the brain by self-templating their disease-associated conformation onto natively-folded tau monomers, thereby inducing their aggregation and incorporation into growing fibrils. As such, the inhibition or modulation of tau seeding and aggregation represents a viable therapeutic strategy for AD and other tauopathies.
Methods: We have recently developed seed amplification assays (SAA) for the detection and amplification of small quantities of misfolded protein aggregates in various neurodegenerative diseases. In this article, …