Digital Commons Network^™

A Phase 2 Study Of Cpx-351 In Combination With Venetoclax In Patients With Newly Diagnosed High-Risk Acute Myeloid Leukemia, Wei-Ying Jen, Jennifer Croden, Emmanuel Almanza-Huante, Courtney Dinardo, Kelly Chien, Danielle Hammond, Wei Qiao, Yesid Alvarado, Lucia Masarova, Andres E Quesada, Sherry Pierce, Alex Bataller, Guillermo Garcia-Manero, Amin Alousi, Nicholas Short, Naval Daver, Farhad Ravandi, Hagop Kantarjian, Tapan M Kadia

Faculty, Staff and Student Publications

Venetoclax has been combined with intensive chemotherapy regimens in the treatment of acute myeloid leukemia (AML). We aimed to investigate the safety and efficacy of venetoclax combined with full‐dose CPX‐351 (CPX + VEN) in newly diagnosed (ND) AML. Seventeen patients with a median age of 59 years (range, 43–69) were treated; 71% had secondary AML, 47% had prior hypomethylating agent (HMA) exposure, 59% had myelodysplastic syndrome (MDS)‐related (MR) mutations, 47% had complex karyotype, and 29% were TP53 mutated. The overall response rate (ORR) was 82% (95% CI, 57–96) with a composite complete remission rate (CRc) of 71% (95% CI, 50–93). …

Multi-Institution Analysis Of Tarlatamab For The Treatment Of Egfr-Mutant Transformed Small Cell Lung Cancer, Alissa J Cooper, Benjamin Herzberg, Mitchell Parma, Kaiwen Wang, Laura Alder, Urs M Weber, Tejas Patil, Utsav Joshi, Sonam Puri, Anjali Saqi, Phoebe Clark, Carl M Gay, Tina Cascone, Eric K Singhi, George Blumenschein, Ferdinandos Skoulidis, Janet Tu, Thomas E Stinchcombe, Charles M Rudin, Catherine A Shu, Lauren A Byers, Helena Yu, Bingnan Zhang

Faculty, Staff and Student Publications

No abstract provided.

Pka-Driven Spp1 Activation As A Novel Mechanism Connecting The Bone Microenvironment To Prostate Cancer Progression, Pablo Sanchis, Agustina Sabater, Julia Lechuga, Jimena Rada, Rocio Seniuk, Gaston Pascual, Mora Gatti, Juan Bizzotto, Peter D A Shepherd, Jun Yang, Javier Cotignola, Elba Vazquez, Joaquin Mateo, Pia Valacco, Estefania Labanca, Christopher Logothetis, Geraldine Gueron, Nicolas Anselmino

Faculty, Staff and Student Publications

Prostate cancer (PCa) bone metastasis (BM) poses a significant clinical challenge due to the heterogeneity of treatment responses and patient outcomes. In this study, we examined the role of Protein Kinase A (PKA) signaling in modulating the expression of osteopontin (SPP1/OPN), a protein associated with poor prognosis, within a subset of PCa BM patients. By integrating multi-omics results we identified a novel mechanism in which bone-derived type-I collagen (Col1a1) and fibronectin (Fn1) stimulate SPP1 expression in PCa cells through the activation of PKA signaling. This bone-induced regulation of SPP1 was confirmed both in vitro, using PCa-bone co-culture systems (PC3 or …

Trickle-Down Coordination: The National Security Advisor’S Role As The Strategic And Operational Planner Of The Dod-Dos Interagency Relationship, Fabio S. Van Loon

Journal of Strategic Security

Forging a coherent U.S. foreign policy requires the competent management of the inter-agency framework. Defining strategy at the cabinet level and ensuring its implementation at the operational level, the National Security Advisor must act as an honest broker of the inter-agency process. This article will examine the role of three National Security Advisors from the Nixon, Carter and George W. Bush administrations, and study two examples of operational success and failure, highlighting the importance of the strategic-operational link. The author concludes by recommending a National Security Council (NSC)-led inter-agency framework that drives consensus-based strategic planning and mandates operational coordination through …

Intelligence As An Instrument Of National Power: Lessons Learned From The Tensions Between Serbia And Kosovo, Vadym Chernysh

Journal of Strategic Security

Intelligence activity is unique; it can be a valuable and powerful tool in the hands of state leaders. Leaders should rely not solely on their perception or intuition to leverage the intelligence instrument of national power but rather on understanding this phenomenon and its inherent qualities. Often, political leadership may confuse the functions of intelligence and law-enforcement agencies, leading to the ineffective or inefficient use of national power instruments to achieve strategic goals. Leveraging the intelligence instrument of national power in prolonged conflicts with a larger adversary is a crucial aspect of statecraft. The role of intelligence can be vital …

The Institutional Effect: Democracies, Dictators And Diversionary Foreign Policy, Thomas Reilly

Journal of Strategic Security

The diversionary theory of war remains controversial in International Relations. The extant literature remains dominated by the study of democratic diversions and the use of warfare as the prime diversionary strategy. The sheer amount of work covering democratic diversions has created theoretical biases which are oft transposed to autocratic states, despite being largely unique to democratic processes. This article expands the traditional bounds of diversionary theory to provide a logic of autocratic diversions and diversionary strategies outside of war, presenting a theoretical framework which argues that institutionalization is the primary conduit through which the intended audience, benefit and preferred diversions …

Vulnerable State’S Foreign Policy Navigation In A Multipolar World: Discerning Ethiopia’S Security Engagement With Turkey, Henok Getachew

Journal of Strategic Security

Throughout its modern history, the Ethiopian state has operated in space that constraints its strategic autonomy. Since the mid of the twenty-first century, the Ethiopian state has consistently struggled to survive in the face of formidable challenges that manifested in the forms of irredentism, aggression, civil war, and external pressure. To deal with such security conundrums, maintaining strategic partnership for instance is not a new phenomenon in the tradition of Ethiopia’s foreign policy. Over the years, it has employed inter alia alliance, loose partnership, and asymmetric relationships with other states as well as collective security to ameliorate security risks originating …

The I2u2: China’S Increasing Role In The Middle East And Geostrategic Implications On India, Pooja Devi, Jyoti Singh Ph.D.

Journal of Strategic Security

In the present era, the concept of minilateralism has emerged as an essential instrument of the attainment of a country’s strategic interests. Consequently, the global world is shifting from multilateral alliances to minilateral groupings. The article analyzes the emergence of a minilateral construct and the formation of minilateral platform I2U2. The newly established quadrilateral group I2U2, which includes India, Israel, the UAE and the United States, is called ‘the Middle East Quad.’ The economic partnership is aimed at utilizing the different sector capacities of member countries to counter shared challenges that have occurred in the past few years. Six key …

India’S Policy Shift Towards Afghanistan Under De Facto Taliban Government, Neha Manhas, Sitakanta Mishra

Journal of Strategic Security

The Taliban takeover of Afghanistan is no longer at the forefront of the global agenda, though after four years of its rule, the Islamic Emirate strives for global legitimacy. India, one of the major partners in the reconstruction of Afghanistan since 2001, has drastically minimized its role, and no major attempt was made to deal with the Taliban until the withdrawal of US/NATO forces in 2021. Similarly, the Taliban regime in turn has not made any breakthrough with India in its diplomatic pursuits. However, sporadic meetings between the Indian and Taliban government officials have taken place, leading to speculation …

Looking Inside Seychelles Beneficial Multi-Alignment Strategy Amidst India-China Competition, Gaurav Sen

Journal of Strategic Security

The article is designed to understand the political strategy of Seychelles. Seychelles situated in Western Indian Ocean has emerged as key player in the Indo-China competition. India and China are striving to exert influence over small island state, which hold strategic significance in the contested waters of the Indian Ocean. Seychelles has been adept at maintaining beneficial relationships with both India and China, despite its differing strategic interests. This article undertakes a detailed overview of Seychelles political strategy during India- China competition in the IOR. The first part of the paper devoted in understanding the importance of political strategy and …

Assessing India-Philippines Defence Engagement: Strategic Alignments And Future Trajectories, Arushi Anthal, Anu Sharma

Journal of Strategic Security

India and the Philippines signed the deal worth USD 375 million dollars for the BrahMos supersonic cruise missiles in 2022, and the first batch of missiles was delivered in April of 2024. The growing defence cooperation between both nations marks a strategic shift in India’s Act East Policy which was launched in 2014. Within the broader Indo-Pacific framework, this engagement offers mutual advantages in maritime security, counter-terrorism, and capacity building. This research paper explores and examines the strategic relevance of this partnership in lines with the rising assertiveness of China, assesses challenges and identifies potential areas of cooperation. It also …

Threat Perception In Taiwan: Trend And Implications, Christina Chen

Journal of Strategic Security

The rising tensions in the Taiwan Strait, driven by China’s growing aggression, have prompted Taiwan to explore ways to bolster its defense and deterrence capabilities. Given that successful deterrence requires the involvement of both military and civilian sectors, the Taiwanese public’s threat perception—specifically, how they view China as a security threat—becomes crucial. This article examines changes in Taiwan’s public threat perception of China. It finds that while Taiwan’s public threat perception has increased since the late 2010s, this shift is more nuanced. External events likely contributed to an overall rise in threat perception, but Chinese coercive actions were associated with …

Growth Of Reusable Space Technology: Commercial Opportunities And Military Advantages, Khyati Singh

Journal of Strategic Security

This paper examines the evolution and implications of reusable space technology, focusing on its impact on commercial opportunities and military advantages. The analysis traces the development from early concepts through the current "third space age," marked by successful commercial ventures like SpaceX and Blue Origin. The study explores how reusable technology has transformed space access by significantly reducing launch costs and increasing mission frequency. It evaluates key technological breakthroughs, including advanced materials, precision landing systems, and improved propulsion systems that enable reusability. The paper further analyses the commercial landscape, discussing emerging markets in satellite constellations, space tourism, and orbital manufacturing. …

The Element Of Surprise: Highly Maneuverable Satellites And Ssa, Simone L. Montandon

Journal of Strategic Security

Military, commercial, and civil space missions rely on accurate space situational awareness (SSA) to avoid collisions and inform the analysis of the threat environment. Historically, man-made objects in space have been highly predictable because their trajectories were mostly constrained within the orbit they occupied. However, fast-paced progress in engine/thruster technology, energy efficiency, and on-orbit servicing and refueling have allowed satellites to maneuver often and quickly within their lifespan. This added an element of unpredictability that adds further uncertainty to an operational environment that is already highly uncertain. This paper argues that solving this issue will require pursuing continued custody of …

Identifying Signatures Of Unidentified Aerospace Phenomena Through Structured Analytic Techniques, Joshua S. Pierson, Ms, Dss

Journal of Strategic Security

Unidentified Aerospace Phenomena (UAP) penetrate sovereign airspace and sea space with such proliferation that often national security entities are left baffled with how to detect, identify, and respond to such actions. Since World War II, these phenomena were reported to pace aircraft, maneuver at high speeds in an erratic fashion and increase speed to hypersonic velocity when starting from stasis. The study of UAP is shrouded in stigma, perplexing government mishaps, and academic inquiry focusing on the material aspects of UAP, leaving a gap in determining the exhibited capability and intent of these phenomena. The use of structured analytic techniques …

Subterranean Warfare’S Strategic Coming Of Age: The Israel-Hamas War Of 2023-Present, Nadav Morag

Journal of Strategic Security

This article posits the question as to whether subterranean warfare, which has been a tactic used in warfare since ancient times, has evolved to being an operational tactic in some contexts (such as in the Vietnam War and some Israeli-Hamas clashes in Gaza prior to 2023) and has now, for the first time, has “come of age” to the strategic level in the Israel-Hamas war that broke out in October 2023. The article argues that the current war in Gaza is one in which subterranean warfare has become strategic because the outcomes of this form of warfare in this context …

Sofs And Pmscs: Factors Of Stability And Change, Mirko Tasic

Journal of Strategic Security

The legitimacy of special operations forces (SOFs) and private military and security companies (PMSCs) often resides in a legal gray area, especially for those operating under the patronage of states that deviate from neoliberal standards and are sometimes labeled as criminal groups or terrorist organizations. This study aimed to develop a framework for categorizing the organizational and operational models of such SOFs and PMSCs. The three primary categories used were: mercantilistic, ideological, and ideological-mercantilistic. A comparative analysis of Iran’s Quds Force, Russia’s Wagner Group, and FR Yugoslavia’s JSO was conducted to better understand the impact of these and similar actors …

Ai-Enabled Terrorism: A Strategic Analysis Of Emerging Threats And Countermeasures In Global Security, Shai Farber

Journal of Strategic Security

The rapid advancement of artificial intelligence (AI) is transforming terrorist methods and counter-terrorism strategies, with far-reaching effects on global security. This paper examines how terrorists use AI for new attack tactics, propaganda, and coordination, while also evaluating the ethical, legal, and strategic challenges AI introduces into counter-terrorism. Through a systematic literature review and qualitative analysis, the study identifies key trends in AI's impact on security dynamics, highlighting its role in blurring the lines between peace and conflict. An analytical framework is proposed to navigate the complex landscape of AI-driven asymmetric warfare, providing practical insights for policymakers and researchers. The study …

Detecting Drone Threats At Stadiums And Public Venues: Overview, Operational Considerations, And Technical Implementation, Nathan P. Jones, John P. Sullivan, George W. Davis Jr.

Journal of Strategic Security

This article overviews the issue of drone threats to stadiums and public venues. It provides emergency managers and those defending this critical infrastructure with an overview, operational considerations, and a discussion of the technical implementation for defending these sites from drone threats through detection. It provides a discussion of the current limitations of countermeasures and legal frameworks relevant to drones. Throughout, this article uses real drone detection data from the Astroworld concert incident (November 2021) as a notional case study to illustrate the type of drone detection data emergency managers will contend with and what can be gleaned from it. …

Strategic Leadership In Security Media: Enhancing Community Safety Against Drug Abuse In Oman, Raed Awashreh, Saif Alshuhoomi,, Viola Gjylbegaj

Journal of Strategic Security

Rapid global development has led to increased security challenges, particularly regarding drug-related crimes. This study examines the role of strategic leadership in security media to enhance community security, focusing on drug abuse in Oman. Despite ongoing efforts to combat drug-related offenses, these crimes remain a significant threat to societal stability. The qualitative research involved in-depth interviews with 14 decision-makers, including 7 experts from Oman’s security media, police, and related institutions. It explores the effectiveness of security media campaigns in raising awareness and reducing drug use. Thematic analysis of the data revealed key challenges, including limited resources, outdated technologies, and insufficient …

The Great Displacement: Climate Change And The Next American Migration. By Jake Bittle. New York, N.Y.: Simon & Schuster, 2023., Christopher John Cook

Journal of Strategic Security

No abstract provided.

The Combination Of All Forms Of Struggle: Insurgent Legitimation And State Response To Farc. By Alexandra Rachel Phelan. Columbia Studies In Terrorism And Irregular Warfare. New York: Columbia University Press, 2024., Thomas A. Marks

Journal of Strategic Security

No abstract provided.

Policing The Favelas Of Rio De Janeiro: Cosmologies Of War And The Far-Right. By Tomas Salem. Cham, Switzerland: Palgrave Macmillan, 2024., Jorge M. Lasmar

Journal of Strategic Security

No abstract provided.

Fairer Public Benefit In Copyright Law, Amanda Levendowski Tepski

Cardozo Law Review

In 1966, a court considered expressly whether a secondary use of copyrighted works served a public benefit. While public benefit has become a subfactor of the fair use doctrine, it remains undefined, uncodified, and undertheorized. Courts often invoked public benefit in pivotal cases involving novel technologies, from home video recorders to digital libraries to algorithms—but they did not need to. After the recent Supreme Court decision in Google v. Oracle, however, public benefit is unavoidable: The Court stated that “we must take into account the public benefits the copying will likely produce.” A qualitative analysis of key public benefit cases …

Do Civil Penalties Punish? The Fbar Penalty And The Case For An Emboldened Excessive Fines Clause, Scott Oatkin

Cardozo Law Review

The Report of Foreign Bank and Financial Accounts (FBAR) regime authorizes the IRS to impose severe penalties—up to the greater of $100,000 or fifty percent of the account balance—for failure to report foreign bank accounts exceeding $10,000. While the Eighth Amendment protects Americans from “excessive fines,” circuit courts are split on whether the FBAR penalty constitutes a fine and is subject to constitutional scrutiny. Some courts have found that the FBAR penalty is wholly remedial and beyond the reach of the Excessive Fines Clause, but this Note argues that such an interpretation is inconsistent with the history and case law …

Redbird Scholar, Vol. 11, No. 1 (Fall 2025), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

Tirzepatide For The Maintenance Of Body Weight Reduction: Rationale, Design, And Baseline Characteristics Of Surmount-Maintain, Deborah B Horn, Louis J Aronne, Sean Wharton, Harold E Bays, Elisa Gomez-Valderas, Avigdor D Arad, Palash Sharma, Julia P Dunn, Cagri Senyucel, Clare J Lee

Faculty, Staff and Student Publications

Objective: SURMOUNT-MAINTAIN aims to evaluate the efficacy and safety of reducing the tirzepatide dose and/or continuing the maximum tolerated dose (MTD) versus placebo in maintaining body weight (BW) reduction achieved with tirzepatide MTD.

Methods: This Phase 3b, multicenter, randomized, parallel-arm, double-blinded, placebo-controlled, 52-week clinical trial is in progress comparing treatment with once weekly tirzepatide (5 mg and/or MTD of 15 mg or 10 mg) versus placebo in achieving BW reduction maintenance from the initial 60-week open-label weight-loss period on tirzepatide MTD, in adults with obesity (BMI ≥ 30 kg/m2 or ≥ 27 kg/m2 with ≥ 1 obesity-related comorbidity, excluding type …

Tofacitinib Ameliorates Campylobacter-Induced Intestinal Pathology By Suppressing Ifnγ Producing Ilcs And T Cells, Anna A Korchagina, Sergey A Shein, Wayne T Muraoka, Justin Nguyen, Qiangxing Chen, Anna A Tumanova, Austin W Todd, Carlos E Rivera, Rita Tamayo, Paolo Casali, Ekaterina Koroleva, Alexei V Tumanov

Faculty, Staff and Student Publications

Patients with autoimmune diseases are more susceptible to foodborne infections, which can be exacerbated by immunosuppressive therapy. Tofacitinib, a JAK/STAT pathway inhibitor, was recently approved for the treatment of ulcerative colitis, yet its effects on the pathogenesis of intestinal infections remain unclear. Here, we examined the impact of oral tofacitinib treatment in a mouse model of Campylobacter jejuni (C. jejuni) infection. Our results show that early tofacitinib administration attenuates intestinal pathology without affecting bacterial colonization. Specifically, tofacitinib suppressed CXCL1, CXCL2, CCL2 chemokine expression by intestinal epithelial cells, limiting recruitment of monocytes and neutrophils to the gut. In addition, JAK/STAT inhibition …

Family History Of Substance Use And Stressful Life Events Impact Adolescent Maturation Of Cerebral White Matter, Yizhou Ma, Ashley Acheson, Corneliu Bolbocean, Mustafa N Mithaiwala, Si Gao, Neda Jahanshad, Paul M Thompson, Bhim M Adhikari, Xiaoming Du, A Ankeeta, Alia Warner, Antonio F Pagán, L Elliot Hong, Peter Kochunov

Faculty, Staff and Student Publications

Family history (FH) of substance use disorders (SUDs) and stressful life events (SLEs) are known risk factors for SUDs in adolescents and young adults. Cross‐sectional studies suggest that FH and SLEs affect adolescent white matter (WM) development and form abnormal WM patterns. Here, we examined the effects of FH, SLEs and their interaction on WM integrity in youths in the Adolescent Cognitive Brain Development (ABCD) study at baseline and 2‐ and 4‐year follow‐ups. ABCD youths (N = 8939, age ± SD = 9.9 ± 0.6 years, 4302 female) completed baseline diffusion tensor imaging, of which 5661 repeated the scan …

Succinate Dehydrogenase-Related Pheochromocytoma And Paraganglioma (Sdhx-Ppgl): Clinical And Genetic Insights From An Indian Study, Ketki Sunil Ambulkar, Anima Sharma, Vijaya Sarathi, Saba Samad Memon, Anurag Ranjan Lila, Rohit Barnabas, Manjiri Karlekar, Virendra Patil, Samiksha Hegisthe, Gwendolyn Fernandes, Sameer Rege, Gaurav Malhotra, Hemangini Thakkar, Nalini S Shah, Tushar R Bandgar

Faculty, Staff and Student Publications

Objective: Data on succinate dehydrogenase-related pheochromocytoma and paraganglioma (SDHx PPGL) in India are limited. We describe the clinical and genetic characteristics of SDHx PPGL from a single center in western India.

Design, patients, and measurements: A retrospective review of SDHx PPGL patients was performed for clinical, imaging, genetic, and treatment details.

Results: Among 46 patients (39 probands, 24 males), the median age at diagnosis was 32.5 (IQR: 23-41) years. We report the youngest patient with SDHC (age 8 years). SDHB mutations were the most prevalent (24/39 probands), followed by SDHD, SDHC, SDHA, and SDHAF2. We report the first Indian family …