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Ethical Sourcing In The Context Of Health Data Supply Chain Management: A Value Sensitive Design Approach, Camille Nebeker Edd, Ms, Ellen Wright Clayton, Et Al. Oct 2025

Ethical Sourcing In The Context Of Health Data Supply Chain Management: A Value Sensitive Design Approach, Camille Nebeker Edd, Ms, Ellen Wright Clayton, Et Al.

Vanderbilt Law School Faculty Publications

Abstract

Objective

The Bridge2AI program is establishing rules of practice for creating ethically sourced health data repositories to support the effective use of ML/AI in biomedical and behavioral research. Given the initially undefined nature of ethically sourced data, this work concurrently developed definitions and guidelines alongside repository creation, grounded in a practical, operational framework.

Materials and Methods

A Value Sensitive Design (VSD) approach was used to explore ethical tensions across stages of health data repository development. The conceptual investigation drew from supply chain management (SCM) processes to (1) identify actors who would interact with or be affected by the data …


Mentoring Programs For Youth In Hagerstown, Maryland: Addressing The Opioid Epidemic, Stephane Reed Oct 2025

Mentoring Programs For Youth In Hagerstown, Maryland: Addressing The Opioid Epidemic, Stephane Reed

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: The goal of this social change portfolio is to help develop and promote mentoring programs for youth in Hagerstown, Maryland as preventive strategy to reduce the impact of the opioid epidemic. This initiative seeks to strengthen resilience, enhance academic performance and foster healthy decision-making among adolescents through consistent, supportive adult-youth relationships. The proposed mentoring framework to integrate culturally responsive, trauma-informed and community-based approaches address the systemic and interpersonal factors contributing to misuse in Washington County. Significant Findings: In Washington County, where Hagerstown is located, it continues to experience one of the highest opioids overdoes within Maryland which is …


Addressing Mental Health And Homelessness In The Lower Valley, Viere Arellano-Almazan Oct 2025

Addressing Mental Health And Homelessness In The Lower Valley, Viere Arellano-Almazan

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: To reduce homelessness in the Lower Yakima Valley by implementing early intervention and culturally responsive mental health prevention strategies that enhance access to care, reduce stigma, and strengthen community resilience. Significant Findings: The Lower Yakima Valley faces significant challenges in addressing the intersection of mental health and homelessness due to limited access to culturally and linguistically appropriate care. Research indicates that rural residents particularly Hispanic immigrant and farmworker populations experience elevated levels of psychological distress, stigma, and barriers to accessing services (Armstrong et al., 2022). Applying the Social-Ecological Model has illuminated how multiple interconnected factors influence vulnerability, including …


Veteran Suicide Prevention In Central Florida, Michael Terkos Oct 2025

Veteran Suicide Prevention In Central Florida, Michael Terkos

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: The goal of this project is to reduce suicide rates among veterans in Central Florida by strengthening protective factors, increasing access to culturally competent, trauma- informed care, and fostering community-based resilience networks that connect veterans, families, and local agencies. Significant Findings: Veteran suicide remains a critical public health concern in Florida, which continues to rank among the states with the highest veteran suicide rates (Florida Department of Health, 2025). Research indicates that approximately 17 veterans die by suicide each day nationwide (U.S. Department of Veterans Affairs [VA], 2022). Key risk factors include post- traumatic stress disorder (PTSD), depression, …


Tutoring Online During The Covid-19 Pandemic: Use Of Critical Incidents To Improve Practice, A.E. Dreyfuss, Jose Armando Sanchez Diaz, Barakat Adigun, Helen Baraki, Thalyia Thompson Oct 2025

Tutoring Online During The Covid-19 Pandemic: Use Of Critical Incidents To Improve Practice, A.E. Dreyfuss, Jose Armando Sanchez Diaz, Barakat Adigun, Helen Baraki, Thalyia Thompson

Publications and Research

Developing expertise in the practice of online tutoring is presented by peer tutors who provided support to students with synchronous sessions with the onset of COVID-19. The experiences and learning of peer tutors were probed through the use of critical incidents (Flanagan, 1954), and how weekly training meetings provided support to them, creating a collaboration among the tutors and the training manager.


A Review Of The 2024/25 International Moots Season, Siyuan Chen Oct 2025

A Review Of The 2024/25 International Moots Season, Siyuan Chen

Research Collection Yong Pung How School Of Law

This is the 11th annual review of Singapore’s performance in international moot court competitions. In a nutshell, 2024/25 has been a tremendous, record-breaking season for Singapore – and a particular duck has finally been broken. In the highest-tier or Grand Slam competitions, Singapore Management University emerged world champions in the Jessup, Vis East, International Criminal Court, and Frankfurt competitions; the previous world record for most Grand Slam wins in a season was 2 (held by various universities), and this new record may well increase to 5, depending on whether SMU can successfully defend its world championship at the Lachs Space …


How The Billable Hour Can Survive Generative Ai, Jonah Perlin Oct 2025

How The Billable Hour Can Survive Generative Ai, Jonah Perlin

Georgetown Law Faculty Publications and Other Works

The legal profession is rapidly adopting generative AI technology. With this shift has come an increasingly common assumption that generative AI will significantly reduce or even bring an end to hourly billing. The logic underlying this conclusion seems intuitive: if AI reduces the time lawyers spend on certain tasks while eliminating others altogether, then the total number of billable hours will fall. That decline, in turn, could threaten the financial viability of hourly billing, despite its place as the dominant law firm compensation model over the past half century.

This Article challenges this assumption. It argues instead that the billable …


Attribution As Architecture In The Digital Age, Laura A. Heymann Oct 2025

Attribution As Architecture In The Digital Age, Laura A. Heymann

Faculty Publications

As technology changes, one thing remains constant: human creators seem to care about attribution, whether as creators or as audience members. Current U.S. law lacks the means for many creators to effectively address attributional interests, and experience has shown that top-down, imposed technological solutions can fail to gain the necessary buy-in and adoption. The best approach, examples suggest, is for platforms to think of attribution as part of the architecture of their systems, but to take their cues from user-developed, individualized solutions, which will not only be more responsive to user interests but also allow adaptation as interests change and …


Supporting Young Children’S Composing Practices Through Pre- And Post-Writing Conversations, Jackie Ridley, Rebecca Rohloff, Xiao Zhang, Margaret Quinn Oct 2025

Supporting Young Children’S Composing Practices Through Pre- And Post-Writing Conversations, Jackie Ridley, Rebecca Rohloff, Xiao Zhang, Margaret Quinn

Journal of Response to Writing

In this teaching tip, we propose purposeful pre- and post-writing conferences as a teacher practice to support young children’s early writing practices. We share how teachers can facilitate children’s idea development through conversational moves during writing conferences and provide a model for what this could look like using a task-based composing prompt.


“What Grade Do You Feel You Earned?” Integrating Student-Led Grading With A Labor-Based Grading Framework, Megan Von Bergen Oct 2025

“What Grade Do You Feel You Earned?” Integrating Student-Led Grading With A Labor-Based Grading Framework, Megan Von Bergen

Journal of Response to Writing

This brief article discusses the advantages of using a student grade proposal within a labor-based grading framework, focusing on how the grade proposal may reinforce the equity-related aims of labor-based grading and hone students' ability to self-assess. The article discusses the learning outcomes of the grade proposal and its process, then ends with a sample grade proposal.


Academic Department Indicators: 2024-2025, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha Oct 2025

Academic Department Indicators: 2024-2025, Systems Intelligence And Data Analytics, University Of Nebraska At Omaha

Academic Department Indicators

The audience is the Academic Planning Council (APC), college and department heads, and faculty. The purpose is to report instructional productivity measures useful for making comparisons and observing trends. Selected departmental information in this report is submitted annually to the Delaware Study, a National Study of Instructional Costs and Productivity.

This Instructional Productivity information corresponds to the UNO state- and tuition-funded budget. The Supplemental Information at the end of the document provides counts and statistics for campus-wide programs embedded in most colleges. Only Dual Enrollment instruction is excluded from the productivity report since it is a fee-based instructional program for …


The Importance Of Self-Care To Avoid Teacher Burnout, Lindsey Brittain Oct 2025

The Importance Of Self-Care To Avoid Teacher Burnout, Lindsey Brittain

Master's Theses & Capstone Projects

Schools across the world are facing the increasingly significant issue of teacher burnout and the ability to retain good teachers. The problem is teachers are experiencing heightened levels of stress, emotional exhaustion, and a lack of motivation in the classroom. Not only is this detrimental to their well-being but it also affects their students. Research has shown that self-care practices can help prevent burnout, but many teachers find it hard to implement these consistently for various reasons. This study aimed to find out how teachers experience burnout and the self-care practices they use to manage stress by using a mixed-methods …


Attachment Styles Connection To Teacher Burnout, Erica Jaeschke Oct 2025

Attachment Styles Connection To Teacher Burnout, Erica Jaeschke

Master's Theses & Capstone Projects

Teacher burnout has become a concern, as teachers are leaving the classroom more frequently than in the past. A teacher's attachment may be associated with the development and persistence of teacher burnout. The problem with this topic is that teachers are leaving the classroom at alarming rates, which is problematic because schools will not have the support they need to educate future generations. This study aims to determine whether teacher burnouts are associated with specific attachment theories. A quantitative method was employed through voluntary survey questions, and 18 teachers participated.


Impact Of Brain Breaks On Student Engagement In An Elementary Classroom, Kailey Hunt Oct 2025

Impact Of Brain Breaks On Student Engagement In An Elementary Classroom, Kailey Hunt

Master's Theses & Capstone Projects

This capstone research project examines the relationship between scheduled brain breaks and student engagement in a third-grade classroom in Bondurant, Iowa. Since the return to in-person learning, classrooms have experienced notable declines in student engagement and motivation. The purpose of this study was to investigate whether incorporating structured brain breaks could provide students with opportunities to reset and reengage during instructional time. Using daily field notes and weekly student surveys, the researcher implemented two brain breaks per day, four days a week, over a four-week period, with 22 students. Findings indicate that short, structured breaks positively influenced student engagement, and …


Cooperative Learning And The Impact On Student Engagement, Erin Pint Oct 2025

Cooperative Learning And The Impact On Student Engagement, Erin Pint

Master's Theses & Capstone Projects

Cooperative learning is an essential instructional approach that supports student engagement. There is limited implementation of this learning method in the classroom which leads to students lacking motivation and opportunities to collaborate with their peers. Research has shown that when teachers incorporate cooperative learning experiences, students demonstrate increased participation which leads to deeper understanding of the content. This inquiry-based research study aims to determine whether cooperative learning can improve student engagement. The study utilized a qualitative approach, using both student and educator surveys as well as field notes. Findings revealed that most students prefer learning alongside at least one peer …


The Impact Of Themes On Students’ Historical Consciousness And Relevance, Madeline Rainey Lincoln Oct 2025

The Impact Of Themes On Students’ Historical Consciousness And Relevance, Madeline Rainey Lincoln

Master's Theses & Capstone Projects

Many students have long perceived history as boring and irrelevant to their lives beyond the classroom. Although recent shifts towards skills-based instruction have attempted to address these issues, students still struggle to recognize the purpose of learning history. This study examined the effectiveness of thematic instructional pedagogy in enhancing 9th-grade students’ historical consciousness and perceptions of relevance in a World History course at a suburban high school in Minnesota. A pre- and post-survey measured students’ views of historical consciousness, thematic learning, and the purpose of learning history before and after a unit of thematic instruction was implemented. Student artifacts, along …


Improving The Use Of Evidence To Support Historical Arguments In A Secondary Classroom, Dylan Vandyke Oct 2025

Improving The Use Of Evidence To Support Historical Arguments In A Secondary Classroom, Dylan Vandyke

Master's Theses & Capstone Projects

The study of history is too often relegated to the basic skills of memorization and summarization. Teaching students history, however, should not be just memorization. Research has shown that the ability of students to take multiple perspectives, analyze cause and effect, and make well-reasons assertions is much more valuable than basic memorization. Tying all these skills together is the concept of being able to present an argument with specific supporting evidence that helps to prove the point. Many freshmen in entry-level high school history courses struggle to use this skill well. This inquiry-based research study aims to help understand why …


Effective Strategies For Creating Inclusive Ell Curricula In Multicultural Classrooms., Katie Struck Oct 2025

Effective Strategies For Creating Inclusive Ell Curricula In Multicultural Classrooms., Katie Struck

Master's Theses & Capstone Projects

This inquiry-based capstone project examines effective strategies for creating inclusive curricula for English Language Learners (ELLs) in multicultural classrooms, with a focus on leveraging students' first languages (L1) to reduce language barriers and promote motivation, cultural representation, and equitable academic outcomes. Amid the rapid growth of ELL populations in U.S. schools—from 8% to nearly 10% of public enrollment between 2000 and 2016—educators in regions like northwest Iowa face challenges in meeting diverse social and academic needs. A literature review synthesizes recent studies on supporting ELL demographics, preparing school staff, addressing barriers, and implementing evidence-based programs and practices. Conducted in a …


Domestic Military Deployments After Trump V. United States, Chris Mirasola Oct 2025

Domestic Military Deployments After Trump V. United States, Chris Mirasola

William & Mary Law Review

The current legal regime governing domestic military deployments was, largely, born of the Civil War. While conflict was ongoing, Congress enacted what are now a pair of statutes criminalizing military interference with federal elections. And as a coda to Reconstruction, Congress criminalized using the military as a civilian law enforcement force. Over the past 160 years, successive Congresses and Presidents have steadily chipped away at these crucial criminal-law protections. In 2024, the Supreme Court’s decision in Trump v. United States further undermined the limitations that remained.

In Trump, the Supreme Court held that Presidents enjoy, at minimum, a presumption …


The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 103, Issue 2, Fall 2025 Oct 2025

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 103, Issue 2, Fall 2025

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

  • 5 - Dean’s Column
  • 6 - Time Machine
  • 12 - ICYMI (In Case You Missed It)
  • 18 - Medicine Rooted in Connection by Scott Orlov, SKMC Class of 2026
  • 20 - All in the Family by Takami Sato, MD, PhD, and Rino Seedor, MD ’15
  • 24 - When Jefferson and Medicine Struck Gold by Geno J. Merli, MD ’75, RES ’78 and ’80
  • 28 - Alumni Weekend Recap
  • 32 - Born a Jeffersonian by William Valentine Harrer, MD ’62
  • 35 - Class Ambassadors
  • 36 - A Message From the SKMC Alumni Board President
  • 38 - Class Notes …


Slb-Mssim: A Spectral Library-Based Multiplex Segmented Sim Platform For Single-Cell Proteomic Analysis, Lakmini Senavirathna, Cheng Ma, Van-An Duong, Hong-Yuan Tsai, Ru Chen, Sheng Pan Oct 2025

Slb-Mssim: A Spectral Library-Based Multiplex Segmented Sim Platform For Single-Cell Proteomic Analysis, Lakmini Senavirathna, Cheng Ma, Van-An Duong, Hong-Yuan Tsai, Ru Chen, Sheng Pan

The Brown Foundation: Institute of Molecular Medicine

Mass spectrometry (MS)-based single-cell proteomics, while highly challenging, offers unique potential for a wide range of applications to interrogate cellular heterogeneity, trajectories, and phenotypes at a functional level. We report here the development of the spectral library-based multiplex segmented selected ion monitoring (SLB-msSIM) method, a conceptually unique approach with significantly enhanced sensitivity and robustness for single-cell analysis. The single-cell MS data is acquired by a multiplex segmented selected ion monitoring (msSIM) technique, which sequentially applies multiple isolation cycles with the quadrupole using a wide isolation window in each cycle to accumulate and store precursor ions in the C-trap for a …


Investigating Machine Learning Algorithms To Classify Label-Free Images Of Pancreatic Neuroendocrine Neoplasms, Noelle Daigle, Shuyuan Guan, Suzann Duan, Thomas G Knapp, Eung-Joo Lee, Ali Azhdarinia, Sukhen C Ghosh, Solmaz Aghaamiri, Servando Hernandez Vargas, Naruhiko Ikoma, Jeannelyn Estrella, Martin J Schnermann, Tobias Else, Michelle Kang Kim, Juanita L Merchant, Travis W Sawyer Oct 2025

Investigating Machine Learning Algorithms To Classify Label-Free Images Of Pancreatic Neuroendocrine Neoplasms, Noelle Daigle, Shuyuan Guan, Suzann Duan, Thomas G Knapp, Eung-Joo Lee, Ali Azhdarinia, Sukhen C Ghosh, Solmaz Aghaamiri, Servando Hernandez Vargas, Naruhiko Ikoma, Jeannelyn Estrella, Martin J Schnermann, Tobias Else, Michelle Kang Kim, Juanita L Merchant, Travis W Sawyer

The Brown Foundation: Institute of Molecular Medicine

Significance: Pancreatic neuroendocrine neoplasms (PNENs) are an uncommon cancer whose incidence rate has increased dramatically in recent years. Surgery is the only potentially curative treatment, which relies on both preoperative tumor localization and postoperative margin definition using histopathological examination for decision making. If pathology could be automated, valuable time and resources could be saved.

Aim: In this study, we investigate the ability of machine learning (ML) with handcrafted features, as well as deep learning, to classify label-free microscopy images of PNENs as a first step toward automated pathology of such tumors.

Approach: Patient samples of two different preparation types were …


It’S Not Elementary, My Dear Ai, Mali Schantz-Feld Ma, Cde Oct 2025

It’S Not Elementary, My Dear Ai, Mali Schantz-Feld Ma, Cde

AADEJ - The Communicator

In this issue, Associate Editor Mali Schantz-Feld cautions dental communicators about the irresponsible use of Artificial Intelligence (AI), highlighting three major risks. The first is the fabrication or "hallucination" of non-existent scholarly references, exemplified by submitted articles where more than half of the citations were fake. The second risk is the removal of human personality, emotion, and nuance, which causes content to feel robotic; this occurred when a profile of an inspiring dentist was run through AI, stripping away their inner light and philosophy. The third danger is the generation of statistics, charts, or figures without providing necessary data or …


Uab Libraries News, 10 2025, Uab Libraries Oct 2025

Uab Libraries News, 10 2025, Uab Libraries

UAB Libraries News

No abstract provided.


Credible Theological Encroachment À La Clemente De Jesús Munguía, Juan Garcia Torres Oct 2025

Credible Theological Encroachment À La Clemente De Jesús Munguía, Juan Garcia Torres

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.


The Distribution Of The Number Of Mutations In The Genealogy Of A Sample From A Single Population, Yun-Xin Fu Oct 2025

The Distribution Of The Number Of Mutations In The Genealogy Of A Sample From A Single Population, Yun-Xin Fu

Faculty, Staff and Student Publications

The number K of mutations in the genealogy of a sample of n sequences from a single population is one essential summary statistic in molecular population genetics and is equal to the number of segregating sites in the sample under the infinite-sites model. Although its expectation and variance are the most widely utilized properties, its sampling formula (i.e., probability distribution) is the foundation for all explorations related to K. Despite existence of an analytic sampling formula, its numerical application is limited due to susceptibility to error propagation. This paper presents a new sampling formula for K in a random sample …


Sleep Eeg And Respiratory Biomarkers Of Sudden Unexpected Death In Epilepsy (Sudep): A Case-Control Study, Oman Magana-Tellez, Rama Maganti, Norma J Hupp, Xi Luo, Sandhya Rani, Johnson P Hampson, Manuela Ochoa-Urrea, Sudha S Tallavajhula, Rup K Sainju, Daniel Friedman, Maromi Nei, Brian K Gehlbach, Stephan Schuele, Ronald M Harper, Beate Diehl, Lisa M Bateman, Orrin Devinsky, George B Richerson, Samden D Lhatoo, Nuria Lacuey Oct 2025

Sleep Eeg And Respiratory Biomarkers Of Sudden Unexpected Death In Epilepsy (Sudep): A Case-Control Study, Oman Magana-Tellez, Rama Maganti, Norma J Hupp, Xi Luo, Sandhya Rani, Johnson P Hampson, Manuela Ochoa-Urrea, Sudha S Tallavajhula, Rup K Sainju, Daniel Friedman, Maromi Nei, Brian K Gehlbach, Stephan Schuele, Ronald M Harper, Beate Diehl, Lisa M Bateman, Orrin Devinsky, George B Richerson, Samden D Lhatoo, Nuria Lacuey

Faculty, Staff and Student Publications

Background: Sudden unexpected death in epilepsy (SUDEP) is the most common category of epilepsy-related mortality. Centrally mediated respiratory dysfunction has been observed to lead to death in the majority of cases of SUDEP. SUDEP also mainly occurs during nighttime sleep. This study seeks to identify sleep EEG and sleep-related respiratory biomarkers of SUDEP risk.

Methods: In this case-control study, we compared demographic, clinical, EEG, and respiratory data from people with epilepsy who later died of SUDEP (the SUDEP group) with data from age and sex-matched living people with epilepsy, classified as high risk of SUDEP (with ≥1 generalised tonic-clonic seizure …


Wire-In-Needle Versus Conventional Syringe-On-Needle Technique For Ultrasound-Guided Central Venous Catheter Insertion In The Internal Jugular Vein: The Win Randomized Trial, Kristen K Thomsen, Jovana Stekovic, Felix Köster, Alina Bergholz, Karim Kouz, Moritz Flick, Daniel I Sessler, Christian Zöllner, Bernd Saugel, Leonie Schulte-Uentrop Oct 2025

Wire-In-Needle Versus Conventional Syringe-On-Needle Technique For Ultrasound-Guided Central Venous Catheter Insertion In The Internal Jugular Vein: The Win Randomized Trial, Kristen K Thomsen, Jovana Stekovic, Felix Köster, Alina Bergholz, Karim Kouz, Moritz Flick, Daniel I Sessler, Christian Zöllner, Bernd Saugel, Leonie Schulte-Uentrop

Faculty, Staff and Student Publications

Purpose: There are different techniques for ultrasound-guided central venous catheter (CVC) insertion. When using the conventional syringe-on-needle technique, the syringe needs to be removed from the needle after venous puncture to pass the guidewire through the needle into the vein. When, alternatively, using the wire-in-needle technique, the needle is preloaded with the guidewire, and the guidewire-after venous puncture-is advanced into the vein under real-time ultrasound guidance. We tested the hypothesis that the wire-in-needle technique reduces the time to successful guidewire insertion in the internal jugular vein compared with the syringe-on-needle technique in adults.

Methods: We randomized 250 patients to the …


Continuous Versus Bolus Norepinephrine Administration And Arterial Blood Pressure Stability During Induction Of General Anaesthesia In High-Risk Noncardiac Surgery Patients: A Randomised Trial, Christina Vokuhl, Karim Kouz, Moritz Flick, Linda Krause, Alina Kröker, Parisa Moll-Khosrawi, Christian Zöllner, Daniel I Sessler, Bernd Saugel, Kristen K Thomsen Oct 2025

Continuous Versus Bolus Norepinephrine Administration And Arterial Blood Pressure Stability During Induction Of General Anaesthesia In High-Risk Noncardiac Surgery Patients: A Randomised Trial, Christina Vokuhl, Karim Kouz, Moritz Flick, Linda Krause, Alina Kröker, Parisa Moll-Khosrawi, Christian Zöllner, Daniel I Sessler, Bernd Saugel, Kristen K Thomsen

Faculty, Staff and Student Publications

Background: Hypotension after induction of general anaesthesia is common in high-risk patients having noncardiac surgery. Anaesthesiologists often give manual boluses of vasopressors repeatedly to maintain blood pressure during induction of general anaesthesia, including the fast-acting vasopressor norepinephrine which has a short half-life. We tested the hypothesis that giving norepinephrine continuously during induction of general anaesthesia, compared with giving it as repeated manual boluses, improves blood pressure stability in high-risk noncardiac surgery patients.

Methods: In this single-centre trial, 72 participants undergoing noncardiac surgery were randomised to continuous norepinephrine infusion or manual bolus norepinephrine administration during induction of general anaesthesia. Blood pressure …


Mitochondrial Haplogroups, But Not Heteroplasmy, Are Associated With Midlife Cognitive Function, Nien Yeh Daphne Yu, Shea J Andrews, Lifang Hou, Myriam Fornage, Kristine Yaffe Oct 2025

Mitochondrial Haplogroups, But Not Heteroplasmy, Are Associated With Midlife Cognitive Function, Nien Yeh Daphne Yu, Shea J Andrews, Lifang Hou, Myriam Fornage, Kristine Yaffe

Faculty, Staff and Student Publications

Introduction: Mitochondrial DNA (mtDNA) variation may influence cognitive performance, but prior findings are inconsistent.

Methods: We analyzed data from 2308 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study, assessing heteroplasmy (mtHz) burden and haplogroups (mtHg) from blood-derived mtDNA at three timepoints and cognitive function across multiple domains. Multivariate linear regression models and multivariate linear mixed models adjusted for age, sex, education, and race.

Results: MtDNA heteroplasmy burden and count were not associated with cognitive performance. However, mtHgs in macro-mtHg L were linked to poorer cognitive outcomes, particularly in processing speed and global cognition in cross-sectional and …