Digital Commons Network^™

Phase Iv Clinical Trials For The Treatment Of Non-Small Cell Lung Carcinoma (Nsclc): A Systemic Review From 2020-2025, Yousif A. Kariri, Mohammed H. Alqasmi, Bijad S. Alqahtani

Saudi Medical Journal

ABSTRACT Objective: To evaluate and provide evidence on drugs investigated in completed phase IV clinical trials for adult non-small cell lung carcinoma (NSCLC) therapy, primarily focusing on treatment objectives and adverse effects. Methods: Clinical research studies from January 2020 to January 2025 were systematically reviewed using the “ClinicalTrials.gov” database. The inclusion criteria focused on publicly available, relevant, and completed Phase IV studies limited to “Clinicaltrials.gov”, while those not meeting these specifications were excluded. As of 3 January 2025, a total of 7,541 Phase IV clinical trials were available on “ClinicalTrials.gov”, of which 121 were related to NSCLC. Results: Six of …

The Effect Of Specialized Management Of Acute Coronary Syndrome On Patient’S Quality Of Life: A Tertiary Care Centre Study., Maan Jamjoom, Muath Alharbi, Waleed M. Malibari, Waleed Alshehri, Mohammed A. Aalem, Wafa D. Althubaity, Nouf K. Alalshaikh, Mahmoud A. Toonsi, Faisal A. Boker

Saudi Medical Journal

ABSTRACT Objectives: To assess the impact of Acute Coronary Syndrome (ACS) on quality of life (QoL) among patients at King Abdulaziz Medical City in Western Jeddah. Acute Coronary Syndrome significantly affect patients’ QoL. Many individuals experience challenges post-ACS. While previous research has identified baseline QoL, access to specialized care, and assessment tools as important factors influencing recovery, limited studies have examined how baseline QoL affects long-term outcomes. Methods: This hybrid cross-sectional study included ACS patients treated at King Abdulaziz Medical City. A sample size of 268 was calculated using RAOSOFT. A culturally tailored questionnaire, derived from the SF-36, was developed, …

The Association Between Inflammatory Bowel Disease And Ischemic Heart Disease: A Retrospective Cohort Study, Mahmoud H. Mosli, Dima M. Alsulami, Yara K. Alghamdi, Abdullah S. Badahdah, Asmaa H. Alhibshi, Thamer M. Alamri, Maan S. Alkhattabi, Khames T. Alzahrani, Hadeel A. Alsufyani, Omar I. Saadah

Saudi Medical Journal

ABSTRACT Objectives: To evaluate the association between Inflammatory bowel disease (IBD) and Ischemic heart disease (IHD). Methods: A retrospective cohort analysis included patients with and without IBD seen at the outpatient gastroenterology clinic of a large tertiary care hospital between January 2015 and October 2022. The primary outcome was the association between IBD and IHD, and the secondary outcome was predictors of IHD in patients with IBD. Results: The study included 400 patients; 291 were IBD patients, and 109 had other non-inflammatory GI disorders. The IBD group displayed significantly lower rates of hyperlipidemia (8.6% vs. 30.3%, p <0.001), diabetes mellitus (DM) (10% vs. 24.8%, p <0.001), and hypertension (11.7% vs. 32.1%, p <0.001) compared to the non-IBD group. Only 2.7% (n=8) of IBD patients developed IHD. Logistic regression analysis did not demonstrate a significant association between IBD and IHD ( p =0.932). Among classical risk factors, only hypertension (OR: 26.2, 95% CI: 2.14–661, p =0.016) and hyperlipidemia (OR: 10.5, 95% CI: 1.32–132, p =0.0405) significantly increased the risk of developing IHD among patients with IBD. Conclusion: In this cohort, there is no increased risk of developing IHD in patients with IBD compared to non-IBD patients.

Molecular Identification Of Respiratory Syncytial Virus, Seasonal Influenza Viruses, And Sars-Cov-2 In Respiratory Tract Infections: A Cross-Sectional Study In Taif City, Mazen M. Almehmadi, Faiha A Alharbi, Ahmad K. Shawush, Mamdouh A. Allahyani, Osama A. Abdulaziz, Ayman S. Alhazmi, Ahmad A. Aghamdi

Saudi Medical Journal

ABSTRACT Objectives: To explore the prevalence of respiratory tract infections (RTIs) in Taif via molecular diagnosis method, to enhance the clinical decision making and the need for vaccination strategies. Methods: A 5864 participants were enrolled in this study, all from Taif city. Samples were collected via nasal swab, throat swab, or sputum sample. The duration of the study were 24 months from January 2023 to December 2024. Samples were transported in viral transport medium. Then processed using GeneXpert system. Fluorescent probes detected viral RNA and reported as detected or not detected. Chi-square test was applied for statistical analysis purposes. Results: …

Diagnostic Accuracy Of Thyroid Nodules With Indeterminate Cytology When Combined With Ultrasonographic Risk, Shaza A. Samargandy, Yousef Z. Khedher, Ghaida A. Alzahrani, Hesham T. Nahhas, Mohammed A. Alshaikh, Saad Samargandy, Khalid A. Alzahrani, Aliaa H. Ghoneim

Saudi Medical Journal

ABSTRACT Objectives: To evaluate the added diagnostic value of ultrasonographic risk levels to cytological diagnoses in nodules with Bethesda III and IV cytology. Methods: This retrospective study was conducted in Jeddah, Saudi Arabia, and involved analyzing thyroid nodules from patients who underwent thyroidectomy between 2016 and 2023. We focused on pathology, US risk stratification based on the 2015 American Thyroid Association (ATA) guidelines, and fine-needle aspiration cytology (FNAC) using the Bethesda system. We calculated malignancy rates for each ultrasound (US) and FNAC category, with the indeterminate cytology groups defined as follicular lesions of undetermined significance (FLUS) and follicular neoplasms (FN). …

Healthcare Transformation Through The Implementation Of A New Population Health Management Approach To Achieve Saudi Arabia’S Vision 2030: The Lessons Learned In The Qassim Health Cluster, Majed S. Alharbi, Emmanuel F. Osagiede, Raed F. Al-Harbi

Saudi Medical Journal

ABSTRACT Objectives: To investigate how the Qassim Health Cluster (QHC) implemented population health management (PHM) in tandem with the goals of Saudi Vision 2030 and to pinpoint the main issues and lessons gained from this implementation. Methods: This research used a descriptive population study design and was conducted between November and December 2024. We collected data using a mixed-method approach, gathering qualitative data from 11 PHM implementers and secondary quantitative data from 102,946 healthcare service users. Results: Qassim Health Cluster’s PHM implementation team established a regional 5-year strategic plan to follow the national PHM framework, utilizing data-based decision-making to implement …

Characterization And Management Of Pain Across Phases Of Intraosseous Infusion In Emergency Department Patients With Non-Cardiac Arrest, Aiping Shi, Juan Chen, Xiaowei He, Chunyan Chen, Ming Sun, Wei Li, Wenxia Xu, Wei Yang, Xiaoqin Han

Saudi Medical Journal

ABSTRACT Objectives: To identify risk factors for moderate-to-severe pain during intraosseous infusion (IOI) in non-cardiac arrest patients in the emergency department (ED). Secondary aims include evaluating pain trajectory across procedural stages and assessing the efficacy of a personalized pain management strategy. Methods: This mixed-methods study analyzed 220 ED patients undergoing IOI (150 retrospective, 70 prospective). The prospective cohort was randomized to standard care (n=35) or personalized pain management (n=35). Pain was quantified using the numeric rating scale (NRS) and critical-care pain observation tool (CPOT). Results: During puncture, 35.33% (53/150) reported no/mild pain. Pain severity peaked during flushing, with 73.33% (110/150) …

A Data-Driven Framework For Optimal Retail Store Location, Ming Hui Tan

Dissertations and Theses Collection (Open Access)

This study develops a data-driven framework for optimal retail store location planning that integrates road network analysis, mobility data and optimization techniques. By addressing the limitations of traditional approaches that rely on outdated census data and manual site selection, this research offers a scalable and adaptable solution for retail expansion in diverse urban environments. Chapters 1 and 2 establish the foundational context and theoretical underpinnings of this research. Chapter 1 introduces the research problem and motivation, highlighting the limitations of existing approaches and defining three key research objectives: automating candidate site identification, improving footfall estimation, and developing a scalable multi-site …

Harnessing Se Community Knowledge For Developer-Centric Code Intelligence, Chengran Yang

Dissertations and Theses Collection (Open Access)

The integration of Large Language Models (LLMs), particularly those tailored for programming tasks—referred to as code LLMs—has created novel opportunities to enhance developer productivity. These advanced models automate routine and repetitive coding tasks, such as code generation and debugging, and enable faster prototyping and more efficient problem-solving. Despite these remarkable advantages, the current generation of code LLMs exhibits notable limitations that impact their practical effectiveness in real-world software engineering scenarios. These models frequently produce code that is inefficient or suboptimal in runtime performance, demonstrate opaque reasoning processes, and struggle to adapt effectively to diverse developer contexts and specific requirements. Moreover, …

Factors Influencing Consumers’ Online Purchase Decisions: Evidence From Amazon.Com, Weiwei Li

Dissertations and Theses Collection (Open Access)

With the rapid expansion of cross-border e-commerce, platform sellers increasingly adopt diverse price formatsto influence consumer decision-making. In this context, consumers’ perceptions of and responses to price information have become a pivotal issue in understanding online purchase behavior. Using Amazon as the research setting, this study employs a dynamic panel model with monthly product-level data spanning January 2024 to June 2025 to investigate how different price formats—such as Prime-exclusive pricing and coupon mechanisms—affect consumers’ online purchase intentions when the out-ofpocket price is held constant. Furthermore, the moderating effect of promotional events is systematically examined.

Departing from prior research that largely …

Design-Led Leadership: A Mixed Methods Study On Understanding How Design Thinking Capabilities Impact Leadership Effectiveness, Tareq Waleed Muhmood

Dissertations and Theses Collection (Open Access)

“Widespread design thinking among organisation leaders is desirable for the creation of a humanly and sustainable future” (R. J. Boland et al., 2008a)

This study investigates the impact of design thinking capabilities on leadership effectiveness through a mixed-methods research design.

While design thinking is widely used in product and service innovation, its application as a leadership development framework remains underexplored.   To address this gap, the study employed both quantitative and qualitative methods, including pre- and post-intervention survey of leaders, their supervisors, and subordinates within an education business in Vietnam (EBV), as well as semi-structured interviews with senior leaders at a …

The Role Of Employee Engagement In Predicting Risk Management Outcome, Jenny Tan

Dissertations and Theses Collection (Open Access)

Risk performance is a key business performance indicator as it measures how well an organization manages its uncertainties. Well-balanced risk performance instills confidence in stakeholders (including investors) and improves organizational performance broadly speaking. This dissertation studies the relationship between Perceived Organizational Support, employee engagement and risk appetite and how that relates downstream to organisational risk performance. Using the lens of Social Exchange Theory (SET; Blau, 1964) I examine how perceived organizational support (POS) predicts employee engagement and how this then relates to risk appetite and subsequent levels of risk taking in an organization. I then make predictions about how exchange …

Is Doing-Good-Enough (Dge) Related To Quitting Or Thriving: Organizational Support Moderates The Link Between Dge And Employee Well-Being, Job Satisfaction And Job Crafting, Yun Zhuo

Dissertations and Theses Collection (Open Access)

This research introduces the construct, Doing-Good-Enough (DGE), a work strategy in which employees consciously meet, but do not exceed, core job expectations. It is a satisficing approach aimed at prioritizing well-being and managing work demands. Three studies were conducted to build the DGE scale and examined its outcomes. Study 1 developed the new measurement scale of DGE by integrating its initial work definition with the existing Quiet Quitting (QQ) scales. Items composing the DGE scale were identified through an exploratory factor analysis (EFA). Study 2 validated the DGE scale as unidimensional via confirmatory factor analysis (CFA) and established its discriminant …

Stories Of Racism And Resistance: A Narrative Analysis Of Stories Told In The Uk Windrush Generation And Descendants Of The Windrush Generation, Jessica Blumsom, Jacqui Scott, Emma Karwatzki, Aishath Nasheeda, David Hernandez-Saca, Alyson Malach, Glenda Andrew

Faculty Publications

The Windrush Generation (WG) and their descendants continue to experience adversity in the UK, including racism and the Windrush Scandal, with such adversities absent from psychological research literature. Intergenerational trauma is a psychological concept explaining that adverse experiences can be transmitted from one generation to impact subsequent generations. There has been limited consideration of the ongoing impact of adverse experiences that span multiple generations, such as experiences of racism within Western Europe. This paper utilised a narrative research design to study the narratives of members of the WG and those of their descendants in the UK. Eight expert by experience …

Teaching Ai For Radiology Applications: A Multisociety-Recommended Syllabus From The Aapm, Acr, Rsna, And Siim, Felipe Kitamura, Timothy Kline, Daniel Warren, Linda Moy, Roxana Daneshjou, Farhad Maleki, Igor Santos, Judy Gichoya, Walter Wiggins, Brian Bialecki, Kevin O'Donnell, Adam E. Flanders, Matt Morgan, Nabile Safdar, Katherine P. Andriole, Raym Geis, Bibb Allen, Keith Dreyer, Matt Lungren, Monica J. Wood, Marc Kohli, Steve Langer, George Shih, Eduardo Farina, Charles E. Kahn, Ingrid Reiser, Maryellen Giger, Christoph Wald, John Mongan, Tessa Cook, Neil Tenenholtz

Department of Radiology Faculty Papers

No abstract available

Teaching Ai For Radiology Applications: A Multisociety-Recommended Syllabus From The Aapm, Acr, Rsna, And Siim, Felipe Kitamura, Timothy Kline, Daniel Warren, Linda Moy, Roxana Daneshjou, Farhad Maleki, Igor Santos, Judy Gichoya, Walter Wiggins, Brian Bialecki, Kevin O'Donnell, Adam E. Flanders, Matt Morgan, Nabile Safdar, Katherine P. Andriole, Raym Geis, Bibb Allen, Keith Dreyer, Matt Lungren, Monica J. Wood, Marc Kohli, Steve Langer, George Shih, Eduardo Farina, Charles E. Kahn, Ingrid Reiser, Maryellen Giger, Christoph Wald, John Mongan, Tessa Cook, Neil Tenenholtz

Department of Radiology Faculty Papers

No abstract available.

Social Determinants And Stage At Presentation Of Oral Cancer: Insights From The Rio Grande Valley, Texas, Taha Al Hassan, Yamama Al Sammarraie, Noah Alhassan, Michael Machiorlatti, Adam Bender-Heine, Rachel Giese

School of Medicine Publications

Background: This study aims to explore the social determinants of health and stage at presentation of oral cavity cancer in the Rio Grande Valley (RGV), a region with significant socioeconomic and healthcare disparities. There has been no comprehensive research conducted to understand the oral cancer burden in the RGV. By filling this critical gap, the study seeks to shed light on regional challenges and inform targeted interventions to improve outcomes.

Methods: A retrospective chart review was conducted using data from University of Texas RGV otolaryngology clinics between January 2019 and June 2022. Of 1,609 patient records reviewed, 64 cases met …

Finding Aid For University Of Mississippi Small Manuscripts(Mum01771)

Archives & Special Collections: Finding Aids (alphabetical)

The collection contains items related to the University of Mississippi. The collection is arranged by subject.

Insect Pests Of Wheat In North India: A Comprehensive Review Of Their Bio-Ecology And Integrated Management Strategies, Gurveer Singh, Neelendra K. Joshi

Entomology and Plant Pathology Faculty Publications and Presentations

Wheat (Triticum aestivum L.) is a vital food crop for majority of the world's population. However, its yield potential is significantly threatened by insect pests, which adversely affect production, quality, and overall food security. The diverse array of insect pests throughout wheat's growth stages necessitates a comprehensive understanding of their interactions with wheat cultivation. This review critically assesses the diversity, biology, ecology, and management strategies of major insect pests in North India, including aphids, termites, pink stem borer, gram pod borer, armyworm, and brown wheat mite. These pests infest wheat at various growth stages, posing significant challenges to sustainable production. …

The Temporal Dynamics Of Attention To Threat And Gad Symptoms: A Study Of Lpp Slopes, Ben Swanson, Matt R. Judah, Grant S. Shields

Psychological Science Faculty Publications and Presentations

Individuals experiencing generalized anxiety disorder (GAD) show heightened attention to threat, as suggested by greater amplitude of the late positive potential (LPP). However, amplitude measurements do not fully capitalize on the high temporal resolution of EEG. Specifically, amplitude does not reflect the rate of change in the LPP over a window of interest, which may be important to understand LPP dynamics in individuals with GAD. Indeed, this rate of change of the LPP (i.e., LPP slope) may reflect attentional orienting. The current study leveraged multilevel models to examine the LPP in relation to GAD symptoms. We hypothesized that more-positive LPP …

Faith Vs. Morality: Do Viewpoints Of Protestant Christians Attending Psu Align With Anti-Transgender Legislation Being Proposed In Oregon?, Asher Schneider

University Honors Theses

Transgender-identifying individuals living within the US face significantly higher rates of discrimination and harassment compared to the general US population. Recently, there have been thousands of legislative measures introduced with the intent of limiting the rights of Transgender and other LGBTQ identifying individuals. Christian Americans are significantly more likely than irreligious Americans to be against various rights for Transgender people, such as the ability to participate in sports or use restrooms that correlate with their self-identified gender rather than their biological sex. Research indicates that recent anti-transgender legislative measures introduced in several states is in part driven by the large …

Mama, Appa, And Titi: What Makes Words Sound Parental? A Phonological Exploration Of Parental Terms In And Beyond The Gender Binary, Madeleine C. S. Kruckemeye , '26

Senior Theses, Projects, and Awards

This paper addresses the following research question: What phonological components make a word sound ‘parental’ cross-linguistically and (how) do those components relate to the social genders associated with the word? The goal in answering this question is to extend Jakobson (1960) and Murdock’s (1959) work to be inclusive of our current understanding of gender and gender roles, and to create more options for queer parents and other families that are recognizable as parental terms, an important factor as found by Frank et al. (2017). The research consists of a literature review, an analysis of cross-linguistic parental terms, and an online …

Effectiveness Is Not A Criterion Here: The Curriculum Marketplace And The Students It Leaves Behind, Serena E. Roche

Cardozo Journal of Equal Rights & Social Justice

No abstract provided.

Over. Back. Around., Sarah Trautwein

Yalobusha Review

No abstract provided.

Mathias Sets Out To Study Death, John Cross

Yalobusha Review

No abstract provided.

Screen Time, Physical Activity, And Vo₂Max In Indonesian Vocational School Adolescents (Aged 15–17): A Cross-Sectional Study, Cahyo Wibowo, Yahya Eko Nopiyanto, Angkit Kinasih, Asarya Reno Kombong, Dian Pujianto, Bayu Insanistyo

Indonesian Journal of Research in Physical Education, Sport, and Health

Physical activity and screen time influence many adolescent' fitness problems. This research aims to determine the relationship between screen time and physical activity on adolescent students' cardio-respiratory endurance (VO2max). This research used observational analysis with a cross-sectional study involving 70 teenage students at an Information and Network Technology Vocational School consisting of male and female teenage students. The Screen Time of Adolescents (QUEST) questionnaire was used to assess screen time, the physical activity instrument used the Global Physical Activity Questionnaire (GPAQ v2.0) to assess physical activity levels, and the VO2max instrument used the 20-meter Multistage Fitness Test (MFT). The data …

Association Between Suboptimal Health Status And Academic Performance: A Cross-Sectional Study Of 1,028 Medical Students In Punjab, Pakistan, Maleha Asim, Misbah Malik, Aneela Jamil, Raheela Yasmin, Ghazala Jawwad, Wajahat Ullah Khan

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Suboptimal health status (SHS) refers to the transitional period between health and illness, characterized by unexplained symptoms and premature changes in functional status without a known medical diagnosis. Objective: The aim is to examine how often SHS occurs and how lifestyle factors influence both SHS and the academic success of medical students. Methods: A Cross-sectional survey was conducted from February 2024 to September 2024 with first- to fifth-year medical students from four randomly chosen medical colleges in Punjab, Pakistan. The Suboptimal Health Measurement Scale (SHMS V1.0), Pittsburgh Sleep Quality Index (PSQI), and Health-Promoting Lifestyle Scale (HPLS) were used to …

Exploring Undergraduate Experiences In Physical Education And Health: A Photovoice Study Of Indonesian Students, Sunarno Basuki, Perdinanto Perdinanto, Akhmad Amirudin

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Research on undergraduate students in Physical Education (PE) and Health particularly in Indonesia and the Global South has predominantly relied on quantitative indicators, often neglecting students’ lived, embodied, and emotional experiences within demanding academic and physical environments. Objective: This study aimed to explore the lived experiences of Indonesian undergraduate students enrolled in PE and Health programs and to examine how these experiences can inform more responsive and inclusive educational practices. Methods: A qualitative participatory design was employed using photovoice. Eight undergraduate students documented their academic and personal experiences through photography over a two-week period, followed by reflective writing and …

Identification Of Characteristics And Incidence Of Injuries In Pencak Silat Athletes In The Adult Competition Category In East Java, Dinda Farida Putri Bahari, Kurniati Rahayuni

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Pencak silat, as a competitive sport, has a high risk of injury. However, data on its characteristics and causative factors during pre-match and matches in East Java are still limited. Objective: This study aims to identify the characteristics and incidence of injuries in adult sparring category pencak silat athletes in East Java during training and matches. Methods: Using a quantitative descriptive method with a cross-sectional survey approach. Data were collected through a survey distributed to 100 athletes (61 men and 31 women) aged 17-22 years from 11 cities/districts in East Java, including information on injury characteristics and causal factors. …

Neuromuscular Hamstring Profile Based On Strength Imbalance As A Basis For Injury Prevention In Youth Football Players, Yulingga Nanda Hanief, Sri Sumartiningsih, Setya Rahayu, Heny Setyawati, Hadi Hadi, Karol Karol Jaskulski

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Hamstring strength imbalance between the left and right sides has been identified as a factor contributing to increased injury risk in athletes. However, few studies have evaluated not only bilateral strength differences but also the magnitude of clinically significant imbalances in various hamstring strength parameters. Objective: This study aims to analyze bilateral hamstring muscle asymmetry in terms of maximum, average, and maximum impulse strength, and to evaluate whether the distribution of high imbalances reaches clinically relevant thresholds associated with potential injury risk. Methods: This study is a cross-sectional observational study. Twenty athletes (n = 20) underwent hamstring strength measurements …