Digital Commons Network^™

Branch-And-Cut-And-Price For Agile Earth Observation Satellite Scheduling, Guansheng Peng, Jianjiang Wang, Guopeng Song, Aldy Gunawan, Lining Xing, Pieter Vansteenwegen

Research Collection School Of Computing and Information Systems

The Agile Earth Observation Satellite scheduling selects and sequences satellite observations of possible targets on the Earth’s surface, each with a specific profit and multiple time windows. The objective is to maximize the collected profit of all observations completed under some operational constraints. The problem can be modeled as a variant of the Team Orienteering Problem with Time Windows (TOPTW). The key differences with the regular TOPTW are twofold: first, a time-dependent transition time is required for each pair of consecutive observations to adjust the camera’s look angles. Second, the time windows of each target vary during different observation cycles, …

Spanish Heritage Speakers And Latinidad: How Spanish Fluency Influences Self-Perceived Latinidad Among Heritage Speakers, David Alejandro Rivera Sandoval, Gladys Valle

Undergraduate Theses and Capstone Projects

Abstract of Research: This study examines 1) how heritage speakers' self-perceived proficiency and fluency in Spanish influence their identity as Latinos, and 2) the generational similarities and differences in their lived experiences. Through surveys and interviews, the relationship between Spanish proficiency and fluency and perceived Latinidad among nine Spanish heritage speakers (with Latin American ancestry) has been assessed. The research suggests that no statistically significant relationship was found between language proficiency or fluency and perceived Latinismo. However, qualitative findings revealed that participants construct their Latino identity based on cultural values, lived experiences, and a sense of belonging rather than language …

Perceived Prejudice Or Discrimination In Medical Care Among Us Adults, Inimfon Jackson, Robert Yu, Joël Fokom Domgue, Sanjay Shete

Faculty, Staff and Student Publications

No abstract provided.

Misfolded Amyloid-Beta Conformational Variants (Strains) As Drivers Of Alzheimer's Disease Neuropathology, Salvatore Saieva, Rodrigo Morales

Faculty, Staff and Student Publications

No abstract provided.

Phase 2 Study Of Monotherapy With Pembrolizumab For Advanced Adrenocortical Carcinoma, Brenda Chahla, Bettzy Stephen, Juhee Song, Vania Balderrama-Brondani, Feyza Yaylaci, Matthew T Campbell, Aung Naing, Mouhammed Amir Habra

Faculty, Staff and Student Publications

Introduction: Adrenocortical carcinoma (ACC) is a rare cancer with suboptimal response to chemotherapy. The role of immunotherapy in ACC management is evolving.

Methods: An investigator-initiated, open-label, phase 2 clinical trial was performed to ascertain the activity and safety of monotherapy with pembrolizumab (a humanized monoclonal anti-programmed cell death protein 1 antibody) in patients with advanced ACC. This study was part of a basket clinical trial (ClinicalTrials.gov ID: NCT02721732). Study participants were enrolled from August 15, 2016, until December 7, 2020. Pembrolizumab (200 mg) was administered intravenously every 3 weeks. All other lines of therapy, including mitotane, were stopped before …

Surgical Outcomes With Neoadjuvant Durvalumab Plus Chemotherapy Followed By Adjuvant Durvalumab In Resectable Nsclc, Tetsuya Mitsudomi, John V Heymach, Martin Reck, Janis M Taube, Shugeng Gao, Yoshitsugu Horio, Jian You, Gaofeng Li, Dinh Van Luong, Somcharoen Saeteng, Fumihiro Tanaka, Stefan B Watzka, Laszlo Urban, Zsuzsanna Szalai, Hiroaki Akamatsu, Jin Hyoung Kang, Francisco J Orlandi, Guzel Z Mukhametshina, Andreas Pircher, Carlos Henrique Andrade Teixeira, Mike Aperghis, Gary J Doherty, Ruth Doake, Tamer M Fouad, David Harpole

Faculty, Staff and Student Publications

Introduction: In AEGEAN, perioperative durvalumab plus neoadjuvant chemotherapy, versus neoadjuvant chemotherapy alone, significantly improved event-free survival (p = 0.004) and pathologic complete response (p < 0.001; primary end points; modified intention-to-treat [mITT] population, which excluded patients with known EGFR or ALK aberrations) with a manageable safety profile in patients with resectable (R)-NSCLC. Here, we report surgical outcomes from AEGEAN.

Methods: Patients with treatment-naive R-NSCLC (stage II-IIIB [N2]) and Eastern Cooperative Oncology Group performance status 0 or 1 were randomized (1:1) to platinum-based chemotherapy plus durvalumab or placebo intravenously (every 3 wk, 4 cycles) before surgery, followed by durvalumab or placebo (every 4 wk, 12 cycles). Surgical outcomes were summarized for the mITT population using descriptive statistics.

Results: A total of 737 out of 740 mITT patients received treatment, 366 and 371 in the durvalumab and …

Sars-Cov-2 Mrna Vaccines Sensitize Tumours To Immune Checkpoint Blockade, Adam J Grippin, Christiano Marconi, Sage Copling, Nan Li, Chen Braun, Cole Woody, Elliana Young, Priti Gupta, Min Wang, Annette Wu, Seong Dong Jeong, Dhruvkumar Soni, Frances Weidert, Chao Xie, Eden Goldenberg, Andrew Kim, Chong Zhao, Anna Devries, Paul Castillo, Rishabh Lohray, Michael K Rooney, Benjamin R Schrank, Yifan Wang, Yifan Ma, Enoch Chang, Ramez Kouzy, Kyle Dyson, Jordan Jafarnia, Nina Nariman, Gregory Gladish, Jacob New, Ada Argueta, Diana Amaya, Nagheme Thomas, Andria Doty, Joe Chen, Nikhil Copling, Gabriel Alatrash, Julie Simon, Alicia Bea Davies, William Dennis, Richard Liang, Jeff Lewis, Xiong Wei, Waree Rinsurongkawong, Ara A Vaporciyan, Andrew Johns, D3code Team, Jack Lee, Ji-Hyun Lee, Ryan Sun, Padmanee Sharma, Hai Tran, Jianjun Zhang, Don L Gibbons, Jennifer Wargo, Betty Y S Kim, John V Heymach, Hector R Mendez-Gomez, Wen Jiang, Elias J Sayour, Steven H Lin

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs) extend survival in many patients with cancer but are ineffective in patients without pre-existing immunity1–9. Although personalized mRNA cancer vaccines sensitize tumours to ICIs by directing immune attacks against preselected antigens, personalized vaccines are limited by complex and time-intensive manufacturing processes10–14. Here we show that mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to ICIs. In preclinical models, SARS-CoV-2 mRNA vaccines led to a substantial increase in type I interferon, enabling innate immune cells to prime CD8+ T cells that target tumour-associated antigens. Concomitant ICI treatment is required for …

Cardiovascular Multimorbidity In Older Adults In The United States By Race And Sex, Michael D Green, Robert J Mentz, Stephen J Greene, Bradley G Hammill, Utibe R Essien, Ying Xian, Erin D Michos, Roland J Thorpe, Matthew E Dupre, Brian Mac Grory, Chi-Tsun Chiu, Emily C O'Brien, Jay B Lusk

Faculty, Staff and Student Publications

Background: It is essential to understand the prevalence of cardiovascular multimorbidity and to recognize disparities by race and sex to promote health equity.

Objectives: The objectives of the study are to investigate disparities in the development and progression of cardiovascular multimorbidity among older adults in the United States and estimate relative life expectancies among patients with cardiovascular multimorbidity.

Methods: This was a nationwide study of a 5% nationwide sample of fee-for-service Medicare beneficiaries aged 65 or older from 2010 to 2020. Multistate survival models were employed to estimate cardiovascular disease (CVD) progression and a microsimulation approach was used to derive …

Acute And Chronic Nasal Inflammation Induces Lymphangiogenesis In The Olfactory Mucosa In Mice, Suzuho Komaki, Ryuichi Imai, Yuzuki Sugimoto, Rei Settsu, Aki Obara, Atsuyoshi Shimada, Robert Dantzer, Geoffroy Laumet, Fumiaki Imamura, Sanae Hasegawa-Ishii

Faculty, Staff and Student Publications

Background: Lymphangiogenesis, the formation of new lymphatic vessels, is primarily driven by VEGF-C-mediated activation of VEGFR-3 and plays a critical role in immune regulation and tissue repair. Although lymphangiogenesis has been well documented in various inflamed tissues, its occurrence and spatiotemporal characteristics in the olfactory mucosa during nasal inflammation remain poorly understood. To address this, we investigated the localization and development of lymphatic vessels in a mouse model of both acute and chronic nasal inflammation.

Methods: Acute inflammation was induced by intranasal administration of lipopolysaccharide (LPS; 10 μg per nostril) in 8-week-old male mice, with saline-treated mice as controls. Behavioral …

Omacetaxine And Venetoclax In Relapsed/Refractory Acute Myeloid Leukemia Or Myelodysplastic Syndrome With Mutant Runx1, Courtney D Dinardo, Wei-Ying Jen, Guillermo Montalban-Bravo, Xuemei Wang, Sanam Loghavi, Sravanthi Lavu, Nicholas J Short, Kelly Chien, Ghayas C Issa, Naveen Pemmaraju, Musa Yilmaz, Michael Andreeff, Gautam Borthakur, Tapan M Kadia, Naval G Daver, Guillermo Garcia-Manero, Christopher P Mill, Xiaoping Su, Warren Fiskus, Kapil N Bhalla

Faculty, Staff and Student Publications

Mutations in RUNX1 (RUNX1mut) occur in 10% to 20% of patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) and are associated with poor outcomes to standard therapy. Omacetaxine mepesuccinate (OM), a semisynthetic analog of homoharringtonine, has been shown to be lethal to RUNX1mut AML cells in vitro through reduction of MCL1 and BCL-XL, and synergizes with venetoclax (VEN) in RUNX1mut AML models. We investigated the safety and efficacy of OM + VEN in relapsed/refractory RUNX1mut MDS/AML in a Bayesian Optimal Interval design. VEN 400 mg daily from days 1 to 14 and OM …

Missing The Target: A Scoping Review Of The Use Of Percent Weight Loss For Obesity Management, Diana Sherifali, Megan Racey, Donna Fitzpatrick-Lewis, Michelle Greenway, Sanjeev Sockalingam, Jun Wada, Soo Huat Teoh, Ian Patton, David Macklin, Elizabeth F C Van Rossum, Luca Busetto, Deborah Bade Horn, J D Patricia Nece, Morgan Emile Gabriel Salmon Leguede, Nicole Pearce, Carel Le Roux, Jamy Ard, Angela S Alberga, Lee Kaplan, Arya M Sharma, Sean Wharton

Faculty, Staff and Student Publications

Introduction: To co-create comprehensive targets for obesity management, we need to understand the genesis and current use of percent weight loss targets in research. The goals of our scoping review are to (1) synthesize the literature on percent weight loss targets for adults with obesity and (2) discuss the percent weight loss targets in context with their health benefits.

Methods: We searched Cochrane, MEDLINE, and EMBASE for English language, pharmaceutical, and/or behavioral intervention studies in adults with obesity where the explicit aim of the study was weight reduction defined as a percent of body weight. Reviewers screened citations and extracted …

Peptide Receptor Radionuclide Therapy-Induced Hypercortisolemic Crisis In Ectopic Cushing Syndrome, Raghavendra Pandit, Chethan Yamichannaiah, Anurag Ranjan Lila, Manjiri Karlekar, Saba Samad Memon, Tushar Bandgar

Faculty, Staff and Student Publications

A woman in her fourth decade of life with metastatic ectopic Cushing syndrome due to a thymic neuroendocrine tumor developed an acute adrenocorticotropin (ACTH)-mediated hypercortisolemic crisis 5 days after initiating lutetium-177-labeled DOTA-[Tyr3]-octreotate (177Lu-DOTATATE) peptide receptor radionuclide therapy (PRRT). She presented with hypertension, rapid weight gain (8 kg in a week), psychosis, and biochemical evidence of severe hypercortisolism: serum cortisol: 141 µg/dL (SI: 3889.7 nmol/L) (reference range, 5-25 µg/dL [SI: 137.9-689.7 nmol/L]), plasma ACTH greater than 2000 pg/mL (SI >440.4 pmol/L) (reference range, 10-60 pg/mL [SI: 2.2-13.3 pmol/L]), potassium: 3.4 mEq/L (reference range, 3.5-5.0 mEq/L). Low-dose intravenous etomidate (0.02 mg/kg/h) was …

Educate, Elevate, Empower: Shaping Future-Ready Teachers For Superdiverse Classrooms, Abdelhamid Helmy Safa

Research outputs 2022 to 2026

This paper critically examines the transformative potential of integrating Community Engagement (CE) and Culturally Responsive Pedagogy (CRP) within Initial Teacher Education (ITE) programs globally. It highlights the significance of community-based learning and the Funds of Knowledge (FoK) framework in preparing educators to address the complexities of superdiverse classrooms. Through a systematic review, the study identifies effective practices and systemic barriers in ITE, advocating for a paradigm shift that aligns teacher preparation with the cultural realities of students. The proposed model synthesizes CRP, CE, and FoK to cultivate critical consciousness and adaptive expertise, essential for fostering inclusive learning environments. By providing …

Evidence-Informed Propositions For A Whole-Of-Program Assessment Approach, Janica Jamieson, Rachel Bacon, Andrea Bramley, Janeane Dart, Simone Gibson, Gemma Jenkins, Meredith Kennedy, Sue Kleve, Claire Palermo

Research outputs 2022 to 2026

Aim: To develop evidence-informed propositions for implementing whole-of-program assessment across dietetic education settings, in response to emerging education theory, technological advances such as generative artificial intelligence, and the need for meaningful learning and trustworthy progression decisions. Methods: A four-stage multiple methods study, grounded in pragmatism, was conducted. Initial propositions were developed through a systematic scoping review of programmatic assessment literature. Thematic analysis was used to identify patterns, which were iteratively refined into themes and then preliminary propositions. These were further refined through workshops with dietetic educators, who provided feedback based on their expertise. A repeated systematic scoping review incorporated recent …

Mine Tailings As A Sustainable Filler For Asphalt Binder–Mastics: A Review, Daniel O. Oguntayo, Nuha S. Mashaan, Sanjay K. Shukla

Research outputs 2022 to 2026

Sustainability has become a primary focus on a global scale. However, there is a threat to sustainable development due to the substantial generation of waste from urbanization and industrialization. Particularly, the accumulation of mine tailings is a problem, an industrial waste by-product from the mining sector. To support sustainable development and promote circular economy, it is imperative to utilize the materials in the production of asphalt mastics. This review examines the performance of mining waste-modified asphalt binder–mastic to create an idea of what tailings might be used for in subsequent studies. This review contributes to knowledge by consolidating research efforts …

Testing If Vitamin K1 Reduces The Progression Of Non-Severe Calcific Aortic Stenosis: Design And Rationale Of The Prevention Of Aortic Stenosis Progression Phylloquinone Ossification Reduction Trial (Passport), William A. Courtney, Jarryd Walker, Aindreas Dorai-Raj, Tom Gilbert, Adil Rajwani, Jamie W. Bellinge, Jonathan M. Hodgson, Graham S. Hillis, Carl J. Schultz

Research outputs 2022 to 2026

Aims Calcific aortic stenosis (CAS) is the most common heart valvulopathy in high-income countries. There is no known treatment for CAS other than replacement of the valve in severe, symptomatic disease. Observational studies and a small openlabel randomized trial have reported that vitamin K1 supplementation may reduce the progression rate of calcification and obstruction in CAS. Methods and results 3PASSPORT(ACTRN12622000447752) will be a prospective, randomized, double-blind, placebo-controlled clinical trial investigating if nutritional supplementation with 10 mg of vitamin K1 can reduce the rate of valvular calcification and haemodynamic progression in CAS. Patients identified to have mild or moderate CAS based …

More Alike Than Not: The Open Access Preferences Of Humanities Scholars, Rachel E. Scott, Ana Dubnjakovic

Faculty and Staff Publications – Milner Library

Several studies have noted that humanists have not been as quick or enthusiastic in their adoption of Open Access (OA) as their colleagues in other disciplines. This article leverages the Ithaka S+R US 2021 Faculty Survey to provide contextualized analysis of the OA and Open Education Resources (OER) preferences of humanities scholars, as well as some practices related to OA and OER, relative to their colleagues in other disciplines. Findings suggest that although humanists do stand apart in many OA preferences, the small effect sizes render these differences less important than previously suspected. The implications of these findings are considered …

Empowering Community Health Workers In Dementia Care In South Texas, Stephanie Santiago-Mejias, Shanae L. Rhodes, Fayron R. Epps, Robin C. Hilsabeck, Noe Garza, Sudha Seshadri, Neela K. Patel

School of Medicine Publications

Alzheimer's disease and related dementias disproportionately affect minority racial and ethnic communities. Community health workers are essential in addressing these disparities. We evaluated the impact of an educational workshop focusing on improving knowledge and preparedness in dementia care. Sixty-one CHWs attended in-person sessions in Texas and completed surveys to measure confidence and plans to apply the knowledge gained. Results revealed a significant increase in confidence in providing dementia care post-training (p < 0.001). Qualitative analysis identified five primary roles of CHWs. These findings demonstrate the potential of training interventions to improve knowledge gaps and empower CHWs to address dementia in underserved communities.

Enhanced Recovery After Neurosurgery: A Narrative Review Comparing Clinical Outcomes, Protocols, And Challenges With Standard Postoperative Care, Tirath Patel, Hamza Yousuf Ibrahim, Rahma Naveed, Aziz Ur Rehman, Maryam Amir, Fatima Nasir, Anum Zia Khan, Nikhilesh Anand

School of Medicine Publications

Background: By integrating evidence-based pre-, intra-, and postoperative therapies, enhanced recovery after surgery (ERAS) protocols have transformed perioperative care in numerous surgical specialties. Although their use in neurosurgery aims to maximize patient recovery, minimize complications, and reduce hospital stays, the evidence remains heterogeneous, and large randomized controlled trials are scarce.

Objectives: This narrative review contrasts the clinical outcomes, advantages, and challenges of ERAS protocols with those of conventional postoperative care in neurosurgery, with a focus on cranial, spinal, pediatric, cancer, and functional procedures.

Methods: A thematic synthesis of peer-reviewed clinical evidence was conducted using PubMed, Scopus, and Google Scholar (2000-2025). …

Advancements In Metastatic Spinal Cord Compression Treatment: A Narrative Review Of Innovations, Challenges, And Future Directions, Tirath Patel, Fathimathul Henna, Iman Sharif, Anaya Noor, Hafiza Tooba Siddiqui, Zarhaish Barkat-Ullah, Mahnoor Ishaque, Najia Ali Khan, Christopher Hanani, Abhishek Goyal, Nikhilesh Anand

School of Medicine Publications

Objective: To synthesize recent advancements in metastatic spinal cord compression (MSCC) treatment, evaluating their efficacy in improving neurological function, pain relief, survival, and quality of life.

Background: MSCC is an oncologic emergency caused by the progression of cancer to the spine and is prevalent in approximately 3-5% of all cancer patients, with a relatively higher incidence of breast, prostate, and lung cancers. MSCC can lead to irreversible paralysis due to loss of vital sensory and motor functions, thus requiring an immediate diagnosis and treatment.

Methods: A systematic PubMed search identified studies published over the past 5 years focusing on advancements …

Recommendations From Multi-Disciplinary Professionals For Survivor-Informed And Comprehensive Care For Human Trafficking Survivors, Christina Tsoi, Timothy B. Smith, Elizabeth Cutrer-Párraga, Devan Clayton, Joshua M. Marshall, Jamila Mastny

Faculty Publications

Background: Human trafficking affects millions of people worldwide with multiple adverse outcomes including psychopathology. Although research on human trafficking has become abundant in other academic disciplines (e.g., public health, criminology, social work), healthcare research specific to the mental health treatment of survivors remains limited. Objective: The purpose of this study was to gather recommendations from professionals about mental health treatment of trafficking survivors. Method: Semi-structured interviews were conducted with 21 multidisciplinary professionals working with trafficking survivors. Data were analyzed using qualitative content analysis methodology. Results: An overarching theme derived from the data concerned the recommendation to implement trafficking survivor-informed care, …

(Un)Just Transitions For Youth And The Disabled? The Exclusionary Pressures Facing Science, Technology, Engineering And Mathematics (Stem) Education, Elizabeth Done, Helen Knowler, Irina Lazar, Sylvia Hayes, Joshua Lait, Andrea Perez-Porres

School of Law, Humanities and Social Sciences

This paper highlights the under-representation of young people with disabilities in STEM subjects and career pathways, with particular reference to the engineering sector given its prominent role in the design of energy systems related to net-zero policies. We consider the role of physical infrastructure, and pedagogic and representational practices, in facilitating the marginalisation and under-representation of young people with disabilities. Ultimately, we seek a broader understanding of the ‘just transition’ that acknowledges the role of education in ensuring the active participation of all young people, regardless of learning difficulty or disability or social identity, in that transition. The research is …

Image Captioning Through The Lens Of The Gricean Maxims: Generating Meaningful And Relevant Image Descriptions, Annika Lindh

Doctoral

Image captioning models enable us to automatically generate natural language image descriptions for previously unseen images. It combines the two fields of computer vision and natural language generation, allowing models to interpret the con tent of an image and communicate that knowledge through natural language text.

Research into image captioning has the potential benefit of reducing the gap in digital information availability between fully sighted individuals and those who are visually impaired. However, automatically generated captions often fail to provide the required level of detail and specificity to achieve this goal. Furthermore, current standard evaluation methods are insufficient at measuring …

Risk Factors To Predict Mortality In People With Seizures Reattending Emergency Departments: A Dual-Centre Study, Rohit Shankar, Madeline Dale, Sarah Lennard, William Henley, Brendan Mclean, Mark Jadav, Richard Laugharne, Gurjit Chohan, Sarah Trippier, Laura Sewell, Jamie Ford, Sarah Davis

Peninsula Medical School

Background: Recurrent seizure-related emergency department (ED) attendances are common and associated with poor outcomes. We aimed to identify factors associated with repeated seizure-related ED use and to develop a mortality risk score among individuals re-attending with seizures. Methods: We conducted a retrospective cohort study across two district general hospitals in South-West England, Royal Cornwall Hospitals NHS Trust (RCH; 2015–2018) and Royal United Hospitals Bath NHS Trust (RUH; 2018–2022). Adults (≥18 years) with ≥2 seizure-related ED attendances were included. Negative binomial regression was used to examine demographic and clinical predictors of repeat attendances. A risk score based on these predictors was …

How Do Community Assets Support Health In A Rural Community? An Ethnographic Case Study, Jennie Hayes, Liz Edwards-Smith, Richard Byng, Kerryn Husk, Katrina Wyatt

Peninsula Medical School

Community assets (including voluntary, community, social enterprise and grassroots initiatives) have the potential to help address health inequalities. There is a growing understanding of the importance of putting communities at the heart of public health to improve population health. Understanding the mechanisms by which grassroots activities support health and wellbeing is important for making commissioning decisions, for community confidence and for the purposes of evaluation. This study takes an ethnographic case study approach to explore one rural community in the south-west of England. We observed activities and interactions, had informal conversations with residents and community leaders and conducted focus groups. …

Comparative Fire Hazards Of Lithium-Ion Battery Chemistries: Linking Thermal Behavior, Gas Toxicity, And State-Of-Charge To Composite Risk Profiles, Aamir Iqbal, Ashish Kakoria, Syed Talha Riaz, Jingmin Xu, Robert Illango Pushparaj, Guang Xu

Mining Engineering Faculty Research & Creative Works

Lithium-ion batteries (LIB) are widely used in electric vehicles (EVs) for their high energy density. However, their fire safety causes concerns because of the toxic gases emission and the challenge to extinguish. The type and quantity of toxic gases released during battery fires remain among the least studied hazards, with limited data available despite their serious health risks. This study examines the thermal and gaseous emission behavior of LIB cells after thermal runaway (TR). Five cell types, Lithium Iron Phosphate (LFP), Lithium Titanate (LTO), and three Lithium Nickel Manganese Cobalt oxide (NMC). The three NMC variants share the same base …

Multicomponent One-Dimensional Quantum Droplets Across The Mean-Field Stability Regime, I. A. Englezos, P. Schmelcher, S. I. Mistakidis

Physics Faculty Research & Creative Works

The Lee-Huang-Yang (LHY) energy correction at the edge of the mean-field stability regime is known to give rise to beyond mean-field structures in a wide variety of systems. In this work, we analytically derive the LHY energy for two-, three-and four-component one-dimensional bosonic short-range interacting mixtures across the mean-field stability regime. For varying intercomponent attraction in the two-component setting, quantitative deviations from the original LHY treatment emerge being imprinted in the droplet saturation density and width. On the other hand, for repulsive interactions an unseen early onset of phase-separation occurs for both homonuclear and heteronuclear mixtures. Closed LHY expressions for …

Ded Printing Process Modeling Using Metal Matrix Composites: In-Situ Feedstock Mixing With Variable Compositions And Empirical Validation, Muhammad Arif Mahmood, Sabin Mihai, Diana Chioibasu, Andrei C. Popescu, Frank Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Directed Energy Deposition (DED) is a promising technology for producing metal matrix composites (MMXCs), but precise control over deposited layer dimensions, particularly in multi-material systems, remains difficult to achieve due to the complex interdependence of operating parameters such as laser parameters, feedstock flow rate, and beam energy attenuation. To address these problems, this work proposes an analytical model that predicts the width, height, and depth of the deposited layers using mixed feedstock compositions in-situ, with a focus on Inconel-718 and TiC MMXCs. The model takes into account variables such as laser power, feedstock density, and mixing ratios to improve layer …

Bending Fatigue In Additively Manufactured Metals: A Review Of Current Research And Future Directions, Md Bahar Uddin, Sriram Praneeth Isanaka, Frank Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Metal additive manufacturing (MAM), also referred to as 3D printing, has proven remarkable in the fabrication of complex metal components in multiple sectors. However, the assessment of this revolutionary process through bending fatigue is frequently impeded due to concerns about mechanical and physical conditions of the printed components. The unique layer-by-layer production process results in varied microstructures, anisotropy, and intrinsic defects that considerably differ from traditionally manufactured wrought metals. This review article aims to integrate and evaluate historical and contemporary research on the bending fatigue of additively manufactured materials. More specifically, the impact of process parameters, build orientation, surface conditions, …

Powder Bed Fusion Of Stainless Steel 304l-Nbc Nanocomposite Produced By Ball Milling Method Using A Laser Beam, Khalid Hussain Solangi, Junaid Iqbal Bhatti, Irfan Ali Tunio, Imdad Ali Memon, Temoor Abbas Larik, Lianyi Chen

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Metal powders with uniformly dispersed nanoparticles, suitable shape, and size for additive manufacturing (AM) processes are highly demanded. However, it is difficult to manufacture metal matrix nanocomposite powders (MMNCs) with uniform dispersion of nanoparticles, optimized shape, and size. This study used high-energy ball milling to disperse NbC nanoparticles with an average length of 400 nm (ex-situ reinforcement) in a Stainless Steel (SS) 304 L matrix. In detail, SS304L-5wt% NbC powders were ball-milled from 4 to 10 h. The results showed that the milled powder particles experienced significant cold-welding during the milling time of 4–6 h, with a wide size distribution. …