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Articles 31051 - 31080 of 1439670
Full-Text Articles in Entire DC Network
Epigenetic Landscape In Lysosomal Storage Disorders: Mechanisms And Modulation, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu
Epigenetic Landscape In Lysosomal Storage Disorders: Mechanisms And Modulation, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu
Department of Pediatrics Faculty Papers
Lysosomal storage disorders (LSDs) are rare substrate-accumulating diseases primarily characterized by mutations in genes encoding proteins involved in lysosomal function, most of which have enzymatic activity. Resulting lysosomal dysfunction leads to the overaccumulation of non- or partially degraded substrates. While it is true that enzyme deficiency is the primary cause of LSDs, the epigenetic alterations in DNA methylation, miRNA expression, and histone modifications appear to be critical mechanisms involved in the pathogenesis of LSDs. As epigenetic marks are, in most cases, reversible, their study becomes vital to developing strategies aimed at reversing epigenome alterations. Although classical therapeutic alternatives aim to …
Deprescription Of Benzodiazepine, Oji Gibson
Deprescription Of Benzodiazepine, Oji Gibson
Walden Dissertations and Doctoral Studies
Background: Benzodiazepines are commonly prescribed for anxiety disorders; however, long-term use increases risks of dependence, cognitive impairment, falls, and overdose. Despite established guidelines recommending time-limited use, inappropriate chronic prescribing remains prevalent in primary care. Purpose: The purpose of this Doctor of Nursing Practice (DNP) project was to develop and implement an evidence-based clinical practice guideline (CPG) to reduce benzodiazepine overprescribing for adults with anxiety disorders in a primary care setting. The goal was to improve prescriber adherence to current best practices and promote patient safety. Methods: This quality improvement project utilized the Johns Hopkins Evidence-Based Practice Model to guide development, …
Impact Of Team Coaching, Team Resilience, And Team Learning Agility On Team Adaptive Performance In Volatility, Uncertainty, Complexity, And Ambiguity Environments, Devon Morris
Walden Dissertations and Doctoral Studies
With volatile and rapidly changing environments, teams are under increasing pressure to adapt and maintain performance. This quantitative, cross-sectional correlational study examined the extent to which team coaching predicts team adaptive performance in volatility, uncertainty, complexity, and ambiguity environments, with team resilience as a mediator and team learning agility as a moderator. An integrated theoretical framework combining conservation of resources theory, social cognitive theory, goal-setting theory, and team coaching theory grounded this study. Participants included 291 working professionals with at least 3 months of team membership and coaching experience, spanning various industries, including technology, healthcare, finance, and government sectors. They …
Understanding The Barriers And Challenges Of Spanish-Speaking Latinos Who Received Calaim Initiative Social Support Services, Jessica De Lara Vallejo
Understanding The Barriers And Challenges Of Spanish-Speaking Latinos Who Received Calaim Initiative Social Support Services, Jessica De Lara Vallejo
Walden Dissertations and Doctoral Studies
Spanish-speaking Latinos continue to face significant barriers when attempting to access social support services through healthcare initiatives such as California Advancing and Innovating Medi-Cal (CalAIM). Despite previous efforts to address this issue, this population continues to encounter barriers such as systemic discrimination, language barriers, and limited access to culturally responsive care. This qualitative study was guided by the consolidated framework for implementation research and used an interpretative phenomenological analysis approach to explore the lived experiences of Spanish-speaking Latino parents whose children received CalAIM asthma home remediation (AHR) services. The purpose of this study was to understand the barriers and challenges …
Posterior Fossa Decompression In Syndromic Children With Chiari-Like Posterior Fossa Crowding: A Nationwide Us-Based Study, Victor Gabriel El-Hajj, Josué Aganze Mwambali, Ihab Ahmad Al-Rikabi, Erik Öhlen, Maria Gharios, Victor E. Staartjes, Joanna M. Roy, Basel Musmar, Pascal Jabbour, Erik Edström, Adrian Elmi-Terander
Posterior Fossa Decompression In Syndromic Children With Chiari-Like Posterior Fossa Crowding: A Nationwide Us-Based Study, Victor Gabriel El-Hajj, Josué Aganze Mwambali, Ihab Ahmad Al-Rikabi, Erik Öhlen, Maria Gharios, Victor E. Staartjes, Joanna M. Roy, Basel Musmar, Pascal Jabbour, Erik Edström, Adrian Elmi-Terander
Department of Neurosurgery Faculty Papers
INTRODUCTION: Posterior fossa crowding, due to cerebellar tonsil herniation, often requires surgery with posterior fossa decompression (PFD). Although most cases are due to a Chiari-1 malformation (CM1), some are due to concomitant congenital conditions, mimicking a radiological CM1. The aim of this study was to compare PFD outcomes between CM1 and the syndromic Chiari-like crowding of the posterior fossa. A national pediatric surgical database was used to compare baseline characteristics and short-term postoperative outcomes.
METHODS: Pediatric patients undergoing PFD (2012-2021) were identified in the ACS NSQIP-P database. Baseline characteristics and 30-day outcomes were compared between syndromic and non-syndromic cases. Multivariate …
Geneseo Authors Celebration 2025, Milne Library
Geneseo Authors Celebration 2025, Milne Library
Geneseo Authors Celebration
Milne Library began a tradition of celebrating faculty authorship in 2009 with a series of workshops and a celebration in collaboration with the Teaching and Learning Center. Over the years it has evolved to more accurately reflect on the variety of academic and creative work done here at Geneseo. The annual Geneseo Authors Celebration is an opportunity for the Library and the campus to celebrate the faculty and truly acknowledge the time and effort that faculty have invested into creating exceptional works that contribute to the scholarly discussions taking place in their disciplines.
Books authored or edited by Geneseo faculty …
Securitizing Kinmen: China’S Gray Zone Strategy And The Evolution Of The Kinmen Model, Ian Murphy
Securitizing Kinmen: China’S Gray Zone Strategy And The Evolution Of The Kinmen Model, Ian Murphy
Political Science & Geography Faculty Publications
This paper examines the evolving dynamics of cross-strait relations through the lens of securitization theory, focusing on China’s strategic deployment of what it calls the Kinmen Model and its implications for regional security. While existing discourse predominantly concentrates on a potential full-scale invasion of Taiwan, this study shifts attention to the strategic significance of the outlying islands and the nuanced employment of securitization to exert indirect control. Utilizing Vuori’s (2008) framework for analyzing securitization in non-democratic contexts, this research conducts a discourse analysis of nineteen Chinese language media sources to dissect the speech acts employed by Chinese media and their …
Gritz, Helen, Sophia Maier Garcia
Gritz, Helen, Sophia Maier Garcia
Bronx Jewish History Project
Helen Gritz, b. 1929, grew up on Barnes Avenue in the Northeast Bronx. Her parents immigrated from Poland, her father arriving first and her mother having to enter illegally through Canada after the establishment of the 1924 Quota Acts. Her father was an expert tailor and a Communist. They lived in an Italian and Jewish neighborhood, with the Jews living in apartment buildings and the Italians living in one-family homes. Nearby, Allerton Avenue was the main shopping area.
Gritz was not allowed to play with the “gasn kinder” (street children) as a young child, instead playing with her …
Reprogramming Tumor Microenvironment Via Systemic Delivery Of Tlr3 Agonist And Manganese Nanoparticle, Young Seok Cho, Xingwu Zhou, Xiaoqi Sun, Ziye Wan, Julia Crowther, Mariko Takahashi, Swetha Kodamasimham, Qi Wu, May Thazin Phoo, Youngseo Na, Kai Han, Zaiye Li, Anna Schwendeman, Steven P Schwendeman, Yu Leo Lei, James J Moon
Reprogramming Tumor Microenvironment Via Systemic Delivery Of Tlr3 Agonist And Manganese Nanoparticle, Young Seok Cho, Xingwu Zhou, Xiaoqi Sun, Ziye Wan, Julia Crowther, Mariko Takahashi, Swetha Kodamasimham, Qi Wu, May Thazin Phoo, Youngseo Na, Kai Han, Zaiye Li, Anna Schwendeman, Steven P Schwendeman, Yu Leo Lei, James J Moon
Faculty, Staff and Student Publications
Toll-like receptor (TLR) agonists, as potent immunostimulatory adjuvants, play a critical role in linking the innate and adaptive immune responses. However, their antitumor effects as cancer immunotherapeutic agents have been limited. Here, we report our finding that manganese ion (Mn2+) potentiates various TLR agonists, leading to robust activation of the TLR pathway and the stimulator of interferon genes (STING) pathway among innate immune cells. In particular, we have observed robust antitumor efficacy after intratumoral administration of a TLR3 agonist and Mn2+. To achieve systemic codelivery of TLR3 agonist and Mn2+, we have developed a low-molecular-weight poly(inosinic:cytidylic acid)-Mn2+ coordination lipid nanoparticle …
Hydration Strategies In Ultra-Endurance Running: A Narrative Review Of Programmed Versus Thirst-Driven Approaches, Shawn C. Wierick, Rosie I. Perez, Xiujing Zhao, Brendon P. Mcdermott
Hydration Strategies In Ultra-Endurance Running: A Narrative Review Of Programmed Versus Thirst-Driven Approaches, Shawn C. Wierick, Rosie I. Perez, Xiujing Zhao, Brendon P. Mcdermott
Health, Human Performance and Recreation Faculty Publications and Presentations
Background/Objectives: Ultra-endurance running (UER) presents unique hydration challenges due to prolonged duration, variable terrain, environmental extremes, and gastrointestinal limitations. Athletes often use either programmed fluid intake (PFI), which prescribes fluid volumes based on estimated sweat rate, or thirst-driven fluid intake (TDFI), which relies on internal cues. This review examines the effectiveness and limitations of each strategy in the context of UER performance and safety. Methods: A narrative review was conducted using a targeted selection of peer-reviewed studies. Both laboratory- and field-based research were included to evaluate the physiological rationale, practical feasibility, and outcomes associated with PFI and TDFI. A total …
Reducing Moral Distress Through Interdisciplinary Collaboration: The Impact Of A Weekly Palliative Care And Neonatology Conference, Kirthi Devireddy, Riddhi Shukla, Rachel Boren, James E Slaven, Rebecca A Baker, Jayme D Allen, Karen M Moody
Reducing Moral Distress Through Interdisciplinary Collaboration: The Impact Of A Weekly Palliative Care And Neonatology Conference, Kirthi Devireddy, Riddhi Shukla, Rachel Boren, James E Slaven, Rebecca A Baker, Jayme D Allen, Karen M Moody
Faculty, Staff and Student Publications
Background: Moral distress is the experience of knowing what ethically right action to take, but being unable to act accordingly, due to external factors. It is an experience common to providers working in the neonatal intensive care unit (NICU) where care for infants, often born at the edges of viability or with other life-limiting diagnoses, includes life and death medical decision-making in the context of uncertain prognoses. Palliative care, which aims to reduce suffering, can assist with staff moral distress by providing space for conversations regarding goals-of-care and end-of-life decision making.
Methods: The palliative care and NICU teams co-developed a …
Association Between Adherence Barriers, Self-Reported Adherence, And Psychiatric Symptoms Among Adults With Bipolar Disorder, Martha Sajatovic, Jennifer B. Levin, Clara Adeniyi, Jessica Black, Celeste Weise, Nicole Fiorelli, Erika Kelley
Association Between Adherence Barriers, Self-Reported Adherence, And Psychiatric Symptoms Among Adults With Bipolar Disorder, Martha Sajatovic, Jennifer B. Levin, Clara Adeniyi, Jessica Black, Celeste Weise, Nicole Fiorelli, Erika Kelley
Faculty Scholarship
Aims: While suboptimal medication adherence is a widely recognized problem for people with bipolar disorder (BD), it is less clear how individual characteristics are associated with varying levels of adherence and how specific adherence barriers impact behaviors. This interim analysis from an ongoing randomized controlled trial (RCT) examined associations between patient-reported adherence, adherence barriers, and mood symptoms among poorly adherent individuals with BD. Methods: RCT participants were adults age ≥ 18 years old with BD Type 1 or 2, difficulties with medication adherence, and actively symptomatic as measured by Brief Psychiatric Rating Scale (BPRS) score ≥ 36, Young Mania Rating …
Hepatic Ischemia-Reperfusion Injury: Underlying Mechanisms And Concepts In Liver Surgery And Liver Transplantation, Jie Zhao, Lidan Hou, Kenneth J Dery, Xiaoyi Yuan, Kang Ho Kim, Jerzy W Kupiec-Weglinski, David R Hall, Caitlin J Thornley, Mark J Hobeika, Holger K Eltzschig, Cynthia Ju
Hepatic Ischemia-Reperfusion Injury: Underlying Mechanisms And Concepts In Liver Surgery And Liver Transplantation, Jie Zhao, Lidan Hou, Kenneth J Dery, Xiaoyi Yuan, Kang Ho Kim, Jerzy W Kupiec-Weglinski, David R Hall, Caitlin J Thornley, Mark J Hobeika, Holger K Eltzschig, Cynthia Ju
Faculty, Staff and Student Publications
Hepatic ischemia-reperfusion injury (H-IRI) is a critical complication in liver surgery and liver transplantation, contributing to graft dysfunction and poor clinical outcomes. When hepatocyte protective mechanisms are insufficient to counteract energy depletion and oxidative stress during ischemia, cell death occurs. Tissue damage during H-IRI leads to the release of damage-associated molecular patterns (DAMPs), which recruit and activate immune cells such as neutrophils and monocytes, orchestrating the initiation, progression, and eventual resolution of sterile inflammation. Extended criteria donor (ECD) livers, particularly steatotic ones, are more vulnerable to H-IRI, leading to poorer outcomes and limiting expansion of the donor pool. However, the …
Fear Avoidance After Concussion Tool (Fact): Patient-Reported Outcome Measure Development And Content Validation, Liam J. Sherwood, Gill Cowen, Mandy Vidovich, Jeanette Hasleby, Jon Patricios, Myles C. Murphy
Fear Avoidance After Concussion Tool (Fact): Patient-Reported Outcome Measure Development And Content Validation, Liam J. Sherwood, Gill Cowen, Mandy Vidovich, Jeanette Hasleby, Jon Patricios, Myles C. Murphy
Research outputs 2022 to 2026
Objective No valid patient-reported outcome measures (PROMs) exist to evaluate fear avoidance behaviour following concussion. This study developed a new PROM to evaluate fear avoidance behaviour following concussion and assessed the PROM content validity. Design PROM development was performed using a qualitative study, and content validation was performed using a mixed-methods approach. Methods The development phase consisted of compiling potentially relevant items (eg, questions) from other PROMs proposed to measure fear avoidance before proceeding to a series of one-on-one semistructured interviews with patient and professional participants. The content validity (relevance, comprehensibility and comprehensiveness) of the PROM was first assessed by …
Bridging Reason And Perception: Searching For The Arguments Of Ptolemaïs Of Cyrene In Works On Music Theory From The Italian Renaissance, Sean Robert Denby
Bridging Reason And Perception: Searching For The Arguments Of Ptolemaïs Of Cyrene In Works On Music Theory From The Italian Renaissance, Sean Robert Denby
Electronic Theses and Dissertations Archive
Ptolemaïs of Cyrene is the earliest known female music theorist from antiquity. Her lost work, Pythagorean Elements of Music, is a substantive addition to the debate on the differences in approaches to reason and perception in harmonic science from Pythagorean and Aristoxenian doctrines. It only survives in three quotations in Porphyry of Tyre’s Commentary on Ptolemy’s Harmonics, a work known and used by humanists and music theorists alike in the Italian Renaissance. Considering that numerous individuals in Renaissance Italy—in particular, Franchino Gaffurio, Gioseffo Zarlino, and Vincenzo Galilei—had access to Porphyry’s Commentary, it is a mystery as to why she does …
Leading Inclusive Education: The Impact Of A City’S Place-Based Pedagogical Partnership With Higher Education On Secondary School Inclusion, Suanne Gibson, Sonia Blandford, George Munn, Jen Shute
Leading Inclusive Education: The Impact Of A City’S Place-Based Pedagogical Partnership With Higher Education On Secondary School Inclusion, Suanne Gibson, Sonia Blandford, George Munn, Jen Shute
School of Law, Humanities and Social Sciences
The focus of this article is leadership for inclusive education. The work presented explores a three-year (2021–2024) place-based pedagogical partnership (PBPP) with schools and higher education (HE) leading change for inclusion and school improvement across Plymouth city’s secondary school network. National and international governments emphasise the role HE has in partnering with its local communities to achieve equal education access, inclusive pupil progress and student equality. The aims of this project and partnership were firstly to build meaningful relationships across secondary school leadership teams, local council, regional government and two city universities, and secondly to develop sustained practices that had …
Preclinical Efficacy Of Tasquinimod-Based Combinations In Advanced Myeloproliferative Neoplasms In Blastic Phase, Warren Fiskus, Lucia Masarova, Christopher P Mill, Christine E Birdwell, Kaberi Das, Hanxi Hou, John A Davis, Antrix Jain, Anna Malovannaya, Taghi Manshouri, Andrew Dunbar, Surbhi Sharma, Tapan M Kadia, Courtney D Dinardo, Prithviraj Bose, Naveen Pemmaraju, Sanam Loghavi, Xiaoping Su, Raajit K Rampal, Marie Törngren, Kapil N Bhalla
Preclinical Efficacy Of Tasquinimod-Based Combinations In Advanced Myeloproliferative Neoplasms In Blastic Phase, Warren Fiskus, Lucia Masarova, Christopher P Mill, Christine E Birdwell, Kaberi Das, Hanxi Hou, John A Davis, Antrix Jain, Anna Malovannaya, Taghi Manshouri, Andrew Dunbar, Surbhi Sharma, Tapan M Kadia, Courtney D Dinardo, Prithviraj Bose, Naveen Pemmaraju, Sanam Loghavi, Xiaoping Su, Raajit K Rampal, Marie Törngren, Kapil N Bhalla
Faculty, Staff and Students Publications
The alarmins, S100A8 (A8) and S100A9 (A9), are low molecular weight proteins belonging to the S100 protein family. A8 and A9 are secreted into the extracellular space and plasma, in which they interact with Toll-like receptor 4, receptor for advanced glycation end products, and CD33. In these studies, we determined the preclinical efficacy of tasquinimod (TQ) against advanced myeloproliferative neoplasm (MPN) cell lines and patient-derived (PD) CD34+ blastic phase (BP; >5% blasts in the peripheral blood) MPN cells. TQ induced loss of viability in cell lines and PD MPN-BP cells, but not in normal CD34+ progenitor cells. In TQ-treated PD …
‘In Texas, Everybody Wants Antibiotics’: Reducing Inappropriate Antibiotic Expectations And Use With A Provider-Patient Communication Tool In Primary Care, Ashley Collazo, Paige Wermuth, Johanan Luna Rodriguez, Kiara Olmeda, Azalia Mancera, Fabrizia Faustinella, Michael K Paasche-Orlow, Roger Zoorob, Barbara Wells Trautner, Larissa Grigoryan
‘In Texas, Everybody Wants Antibiotics’: Reducing Inappropriate Antibiotic Expectations And Use With A Provider-Patient Communication Tool In Primary Care, Ashley Collazo, Paige Wermuth, Johanan Luna Rodriguez, Kiara Olmeda, Azalia Mancera, Fabrizia Faustinella, Michael K Paasche-Orlow, Roger Zoorob, Barbara Wells Trautner, Larissa Grigoryan
Faculty, Staff and Students Publications
Background/objective: Patients often expect antibiotics for self-limiting diseases, pressuring providers to prescribe antibiotics unnecessarily. These expectations also contribute to the unsafe practice of taking antibiotics without a prescription (non-prescription use), such as pills retained from prior prescriptions or antibiotics from non-medical sources. Previous work shows that non-prescription use is due to strong, widely held misconceptions regarding the curative power of antibiotics. To reduce unnecessary use of antibiotics, we developed and pilot-tested a patient-focused, bilingual (English and Spanish) educational tool with patient and provider stakeholder input. The tool, a trifold brochure, included information on safe antibiotic use, potential antibiotic harms and …
Infection After Cd19 Chimeric Antigen Receptor T-Cell Therapy For Large B-Cell Lymphoma: Real-World Analysis From Cibmtr, Kitsada Wudhikarn, Megan M Herr, Min Chen, Michael J Martens, John H Baird, Lohith Gowda, Hemalatha G Rangarajan, Muhammad Bilal Abid, Mohamed A Kharfan-Dabaja, Kirsten M Williams, Siddhartha Ganguly, Jo-Anne H Young, Akshay Sharma, Giancarlo Fatobene, Tania Jain, Christopher G Kanakry, Dipenkumar Modi, Natalie S Grover, Baheyeldin Salem, Marjorie Vieira Batista, Paschalis Vergidis, Dwight E Yin, Amer M Beitinjaneh, Amar H Kelkar, Taiga Nishihori, Jennifer Holter Chakrabarty, Usama Gergis, Melody Smith, Zeinab El Boghdadly, Christopher E Dandoy, Hemant S Murthy, Anna R Huppler, Miguel-Angel Perales, Roy F Chemaly, Joshua A Hill, Marcie Riches, Jeffery J Auletta
Infection After Cd19 Chimeric Antigen Receptor T-Cell Therapy For Large B-Cell Lymphoma: Real-World Analysis From Cibmtr, Kitsada Wudhikarn, Megan M Herr, Min Chen, Michael J Martens, John H Baird, Lohith Gowda, Hemalatha G Rangarajan, Muhammad Bilal Abid, Mohamed A Kharfan-Dabaja, Kirsten M Williams, Siddhartha Ganguly, Jo-Anne H Young, Akshay Sharma, Giancarlo Fatobene, Tania Jain, Christopher G Kanakry, Dipenkumar Modi, Natalie S Grover, Baheyeldin Salem, Marjorie Vieira Batista, Paschalis Vergidis, Dwight E Yin, Amer M Beitinjaneh, Amar H Kelkar, Taiga Nishihori, Jennifer Holter Chakrabarty, Usama Gergis, Melody Smith, Zeinab El Boghdadly, Christopher E Dandoy, Hemant S Murthy, Anna R Huppler, Miguel-Angel Perales, Roy F Chemaly, Joshua A Hill, Marcie Riches, Jeffery J Auletta
Faculty, Staff and Students Publications
Infection is increasingly recognized as a significant cause of morbidity and mortality in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) receiving CD19 chimeric antigen receptor (CAR) T-cell therapy. The current study analyzed the natural history, risk factors, and outcomes of infection in 3350 patients with R/R LBCL receiving commercial CD19 CAR T-cell therapy (n = 2804 axicabtagene ciloleucel [axi-cel], n = 546 tisagenlecleucel) from December 2017 to June 2022. Infection developed in 834 patients (24.9%) within 100 days after infusion, resulting in an infection density of 0.43 per 100 patient days and a 100-day cumulative incidence of 22%. Bacterial, …
Real-World Outcomes Of Infections Following Tisagenlecleucel In Patients With B-Cell All: A Cibmtr Analysis, Hemalatha G Rangarajan, Prakash Satwani, Megan M Herr, Min Chen, Michael J Martens, Kitsada Wudhikarn, Samuel John, Vanessa A Fabrizio, Emily M Hsieh, Amar H Kelkar, Erin Doherty, David I Marks, Olle Ringden, Brian Friend, Matthew S Kelly, Nosha Farhadfar, Tim Prestidge, Nasheed M Hossain, Hongtao Liu, Shahrukh Hashmi, Dipenkumar Modi, Lena E Winestone, Zeinab El Boghdadly, Hemant S Murthy, Miguel-Angel Perales, Roy F Chemaly, Christopher E Dandoy, Joshua A Hill, Anna Huppler, Marcie Riches, Jeffery J Auletta
Real-World Outcomes Of Infections Following Tisagenlecleucel In Patients With B-Cell All: A Cibmtr Analysis, Hemalatha G Rangarajan, Prakash Satwani, Megan M Herr, Min Chen, Michael J Martens, Kitsada Wudhikarn, Samuel John, Vanessa A Fabrizio, Emily M Hsieh, Amar H Kelkar, Erin Doherty, David I Marks, Olle Ringden, Brian Friend, Matthew S Kelly, Nosha Farhadfar, Tim Prestidge, Nasheed M Hossain, Hongtao Liu, Shahrukh Hashmi, Dipenkumar Modi, Lena E Winestone, Zeinab El Boghdadly, Hemant S Murthy, Miguel-Angel Perales, Roy F Chemaly, Christopher E Dandoy, Joshua A Hill, Anna Huppler, Marcie Riches, Jeffery J Auletta
Faculty, Staff and Students Publications
Tisagenlecleucel (tisa-cel) is a CD19-directed chimeric antigen receptor T-cell therapy for relapsed/refractory precursor B-cell acute lymphoblastic leukemia (R/R B-ALL). We report infectious complications for 100 days (D100) following tisa-cel therapy in 471 pediatric and young adults (median age 13.8 years) with R/R B-ALL reported from September 2017 to June 2022. By D100, 137 (29%) patients had an infectious event, with an infection density of 0.542 per 100 person-days at risk. D100 cumulative incidences of bacterial, viral, and fungal infections were 14.1%, 11.6%, and 1.3%, corresponding to infection density scores of 0.296, 0.213, and 0.033 per 100 person-days at risk, respectively. …
Entering A Liminal State When Becoming A Social Prescribing Link Worker And How It Affects Retention: Findings From A Uk Qualitative Study, Stephanie Tierney, Lucy Moore, Debra Westlake, Shoba Dawson, Emma Fuller, Kerryn Husk, David Nunan, Pauline Roberts, Lilly Sabir, Jane R. Smith, Obioha C. Ukoumunne, Kamal R. Mahtani
Entering A Liminal State When Becoming A Social Prescribing Link Worker And How It Affects Retention: Findings From A Uk Qualitative Study, Stephanie Tierney, Lucy Moore, Debra Westlake, Shoba Dawson, Emma Fuller, Kerryn Husk, David Nunan, Pauline Roberts, Lilly Sabir, Jane R. Smith, Obioha C. Ukoumunne, Kamal R. Mahtani
Peninsula Medical School
Aim:To explore factors shaping social prescribing (SP) link workers (LWs) experiences of their job, and how they influence decisions about whether or not to leave it.Background:LWs support healthcare delivery by listening to patients’ non-medical concerns and social or relational difficulties, connecting them to ‘community assets’ (groups, organizations, charities) when relevant to help. LWs try to assist people with often complex emotional and/or social issues. This can affect how they feel in their job.Methods:As part of a mixed methods project on LW retention, a qualitative study was conducted. It involved 20 LWs, purposively selected from respondents to a questionnaire; variation in …
The Long And Winding Road: Planning A Successful Library Orientation For Graduate Students, Kristen Adams, Roger Justus
The Long And Winding Road: Planning A Successful Library Orientation For Graduate Students, Kristen Adams, Roger Justus
Journal of Graduate Librarianship
All new university students would benefit from an orientation focusing on library resources, which should look different for undergraduate and graduate students. But finding a place for incoming graduate student library orientations within the larger campus landscape can be challenging for librarians. Contributing to this struggle is that there is frequently an overemphasis on undergraduate orientations, with the misconception that graduate students have less need for orientations. This article will review how other institutions approach their graduate student orientations and share how ours have developed over five years and will continue to do so as the needs of the library …
Framework-Based Mathematics Intervention: A Practice Guide For School Psychologists, Shaalein C. Lopez
Framework-Based Mathematics Intervention: A Practice Guide For School Psychologists, Shaalein C. Lopez
Journal of Applied Disciplines
School psychologists are charged with providing guidance related to the implementation of evidence-based interventions across academic subjects including mathematics. Despite recent advances in the availability of empirically supported intervention and instructional strategies in math, finding appropriate math-related interventions that go beyond fluency building and metacognitive techniques into the realm of math understanding and concept building remains difficult for school psychologists. The adaptation of a framework-based approach to mathematics intervention, such as one developed by the National Center on Intensive Intervention, provides school psychologists with an evidence-based approach that overcomes numerous barriers to providing support for students struggling with mathematics learning.
Parameters Of Suspension Training On Core Performance: A Critically Appraised Topic, Sara Stiltner, Andrea Cripps
Parameters Of Suspension Training On Core Performance: A Critically Appraised Topic, Sara Stiltner, Andrea Cripps
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Clinical Scenario: The core is a functional unit connecting the upper and lower extremities consisting of abdominal, back, and hip musculature. A highly functional core is essential within the kinetic chain and aids in injury prevention and rehabilitation. Traditional means of core stability training are performed on a stable surface. An emerging mode of core training is suspension training (ST), which utilizes a movement paired with instability to challenge the core stabilizers and increase motor unit recruitment.The purpose of suspension training is to increase muscle activation in core stabilizer’s, while mimicking functional movements.It was the purpose of this research to …
Using External Visual Feedback Techniques To Improve Chronic Ankle Instability: A Critically Appraised Topic, Paxtyn Watkins, Bradlee Wells, Aric J. Warren
Using External Visual Feedback Techniques To Improve Chronic Ankle Instability: A Critically Appraised Topic, Paxtyn Watkins, Bradlee Wells, Aric J. Warren
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Introduction: Lateral ankle sprains (LAS) are among the most common musculoskeletal injury in physically active populations posing a substantial health burden. Individuals who sustain ankle sprains often have a diminished quality of life with prolonged symptoms, decreased levels of physical activity, and the propensity to develop chronic ankle instability (CAI). It is estimated that up to 40% of people who sustain an initial lateral ankle sprain will develop CAI. Many therapeutic interventions exist to help alleviate symptoms and the feeling of “giving out.” This critically appraised topic will examine multiple interventions that involve using external visual feedback methods to improve …
The Impact Of Athletic Retirement On Anxiety In Elite Athletes, A Critically Appraised Topic, Jordan Gorham, Emily Madrak
The Impact Of Athletic Retirement On Anxiety In Elite Athletes, A Critically Appraised Topic, Jordan Gorham, Emily Madrak
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Though there is growing interest in athletic mental health, this interest appears to diminish significantly once an athlete enters athletic retirement. The abrupt transition can precipitate mental health struggles, exacerbated by the lack of adequate preparation for lifestyle after retirement and the attachment of athletic identity to their sport. Consequently, these circumstances may increase symptoms associated with poor mental health, with a specific focus on anxiety. As the athlete retires and moves into different stages of life, research notes that athletes with stronger athletic identities have poorer mental health than those who had weaker athletic identity. While the scrutiny …
Targeted Injection Therapies For Temporomandibular Joint Disorders: A Comparative Review Of Hyaluronic Acid And Botox Techniques, Timothy Alexander, Marissa Siegel, Noah Schnoor, Elizabeth A. Starns
Targeted Injection Therapies For Temporomandibular Joint Disorders: A Comparative Review Of Hyaluronic Acid And Botox Techniques, Timothy Alexander, Marissa Siegel, Noah Schnoor, Elizabeth A. Starns
Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association
Purpose: This study aimed to evaluate the effectiveness of different injection therapies for temporomandibular joint disorders (TMD) and answer the research question: how do botulinum toxin (onabotulinumtoxinA, Botox) and hyaluronic acid (HA) injections affect symptoms of temporomandibular joint disorder (TMD)? Methods: An electronic search of three databases was performed using the search terms “Treatment of TMD or TMJ” and one of the following: 1) “Hyaluronic Acid Injection” or 2) “Intramuscular Botox Injection”. Based on studies done with human patients, the effects of both hyaluronic acid and Botox injections as treatments for TMD were observed and analyzed. Inclusion criteria were: full …
The Impact Of Stereotype Threat And Grit On The Experience Of Imposter Syndrome, Lindsey C. Davis
The Impact Of Stereotype Threat And Grit On The Experience Of Imposter Syndrome, Lindsey C. Davis
River Cities Industrial and Organizational Psychology Conference
In-Progress Research Imposter syndrome (IP) is a psychological phenomenon in which one has an internal experience of intellectual phoniness. This phenomenon is particularly seen within workplaces. Past researchers have found that females tend to report higher levels of IP, with Stereotype Threat (ST) being a cited explanation. A common denominator in much of the literature is how a lack of Belongingness can activate Stereotype Threat in females, especially in male-dominated workplaces. It has been found that individuals high in IP, especially females, tend to experience poor mental health outcomes. Past research has also established a link between IP and Conscientiousness …
Making Sense Of Teaming With Ai: Exploring Human-Ai Team Development Through Interpretative Phenomenological Analysis, Elizabeth A. Johnson
Making Sense Of Teaming With Ai: Exploring Human-Ai Team Development Through Interpretative Phenomenological Analysis, Elizabeth A. Johnson
River Cities Industrial and Organizational Psychology Conference
As artificial intelligence (AI) becomes increasingly embedded in collaborative work environments, Human-AI Teaming (HAIT) is reshaping how employees experience team development and view AI as an active teammate, versus passive tool. This in-progress dissertation study uses Interpretative Phenomenological Analysis (IPA) to explore how employees make sense of team development within HAIT context. Grounded in Business Psychology and designed for I-O psychology application, the study explores how employees interpret milestones of human-AI team development and navigate emerging socio-technical dynamics. The primary research question guiding this inquiry is: How do employees make sense of their experiences of team development while working on …
Psychological Safety In Project-Based Workgroups: The Effect Of Individual Experiences On Performance Outcomes, Jacob Brown, David R. Earnest Dr
Psychological Safety In Project-Based Workgroups: The Effect Of Individual Experiences On Performance Outcomes, Jacob Brown, David R. Earnest Dr
River Cities Industrial and Organizational Psychology Conference
Abstract Psychological safety is a vital resource across all occupations because it enables employees to learn, contribute, and adapt without fear of negative consequences. Psychological safety empowers members of high stakes, project-based teams to raise concerns, share expertise, and act ethically before miscommunications escalate into costly failures. While prior research in healthcare and aviation has underscored benefits of psychological safety in team environments, less is known about how psychological safety operates across other project-based professions (civil engineering, construction, software development, disaster response) and job sectors that rely on temporary, interdependent project teams. Centering on individual perceptions rather than aggregated team …