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Pitx2 Dosage-Dependent Changes In Pacemaker Cell State Underlie Sinus Node Dysfunction And Atrial Arrhythmias, Lieve E Van Der Maarel, M Ridwane Mungroo, Otto J Mulleners, Mathilde R Rivaud, Arie O Verkerk, Karel Van Duijvenboden, Freek H T Tiel Groenestege, Jeffrey D Steimle, Lianne Fokkert, Corrie De Gier-De Vries, Mischa Klerk, Arie R Boender, James F Martin, Bjarke Jensen, Gerard J J Boink, Harsha D Devalla, Vincent M Christoffels Dec 2025

Pitx2 Dosage-Dependent Changes In Pacemaker Cell State Underlie Sinus Node Dysfunction And Atrial Arrhythmias, Lieve E Van Der Maarel, M Ridwane Mungroo, Otto J Mulleners, Mathilde R Rivaud, Arie O Verkerk, Karel Van Duijvenboden, Freek H T Tiel Groenestege, Jeffrey D Steimle, Lianne Fokkert, Corrie De Gier-De Vries, Mischa Klerk, Arie R Boender, James F Martin, Bjarke Jensen, Gerard J J Boink, Harsha D Devalla, Vincent M Christoffels

Faculty, Staff and Students Publications

Physiologically relevant increases in transcription factor dosage and their role in development and disease remain largely unexplored. Genomic deletions upstream of the Paired-like homeodomain transcription factor gene (PITX2), identified in patients with sinus node dysfunction and atrial fibrillation and modeled in mice (delB), rewire the local epigenetic landscape, increasing PITX2 expression. Here, we demonstrate that pacemaker cardiomyocytes in the embryonic delB sinus node ectopically express PITX2 at physiological dosages in a heterogeneous pattern. The prenatal delB sinus node forms discrete subdomains showing PITX2 dosage-dependent mild or severe loss of pacemaker cardiomyocyte identity. Respective subdomain sizes and severity of sinus node …

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Dinaciclib Improves Treatment Response In Chemoresistant Hepatoblastoma, Brian T Hickner, Andres F Espinoza, Rohit K Srivastava, Roma H Patel, Priyanka Rao, Nicholas A O'Brien, Kalyani R Patel, Andrew A Badachhape, Abhishek Kona, Dolores H López-Terrada, Sarah E Woodfield, Sanjeev A Vasudevan Dec 2025

Dinaciclib Improves Treatment Response In Chemoresistant Hepatoblastoma, Brian T Hickner, Andres F Espinoza, Rohit K Srivastava, Roma H Patel, Priyanka Rao, Nicholas A O'Brien, Kalyani R Patel, Andrew A Badachhape, Abhishek Kona, Dolores H López-Terrada, Sarah E Woodfield, Sanjeev A Vasudevan

Faculty, Staff and Students Publications

Chemoresistant hepatoblastoma (HB) is associated with poor outcomes. Cyclin-dependent kinases (CDKs) are potential therapeutic targets because of their critical role in cell growth and chemoresistance. To evaluate the efficacy of CDK inhibition, HB cell lines were treated with dinaciclib and evaluated with cytotoxic, cell-death reversal, and immunoblotting assays. A HB patient-derived xenograft (PDX) model was treated with placebo, vincristine + irinotecan (VI), dinaciclib, or VI + dinaciclib to evaluate tumor growth and response to therapy. We found that dinaciclib had a marked effect on HB cell viability, induced PARP cleavage, and decreased CDK9 protein expression in vitro. Overexpression of CDK9 …

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A Mouse Model Of Lipoatrophy Reveals Relationships Between Beige Fat Appearance And Female Fertility, Elizabeth S Anaya, William Dion, Pradip K Saha, Aaron R Cox, Evelyn De Groot, Avery A Ahmed, Jessica B Felix, Bokai Zhu, Stephanie A Pangas, Sean M Hartig Dec 2025

A Mouse Model Of Lipoatrophy Reveals Relationships Between Beige Fat Appearance And Female Fertility, Elizabeth S Anaya, William Dion, Pradip K Saha, Aaron R Cox, Evelyn De Groot, Avery A Ahmed, Jessica B Felix, Bokai Zhu, Stephanie A Pangas, Sean M Hartig

Faculty, Staff and Students Publications

White adipose tissue (WAT) performs vital metabolic and endocrine functions, but roles in female reproduction remain understudied and poorly understood. Here, we report that female mice experiencing progressive lipoatrophy after knockout of Ubc9 in adipocytes (Ubc9fKO) displayed disrupted estrous cycles, reduced ovarian reserve, and subfertility. During aging, female Ubc9fKO mice lose subcutaneous WAT more quickly than their male counterparts and weigh less than littermate controls. Subcutaneous WAT excised from female Ubc9fKO mice strongly enriched for thermogenesis genes generally associated with metabolic benefits. Female Ubc9fKO mice exhibited hypermetabolism and accumulated thermogenic, Uncoupling Protein 1-expressing beige fat cells in residual subcutaneous WAT …

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A Comprehensive Study Of C-Kit-Expressing Amacrine Cells In The Mammalian Retina, Zheng Jiang, Wen Shen Dec 2025

A Comprehensive Study Of C-Kit-Expressing Amacrine Cells In The Mammalian Retina, Zheng Jiang, Wen Shen

Faculty, Staff and Students Publications

Amacrine cells assemble complex circuits in the inner retina, where they integrate, modulate, and relay spatial and temporal information to retinal ganglion cells. Nevertheless, their organization and functional diversity are still not fully understood. In this study, we identify a distinct group of amacrine cells that express the stem cell factor receptor-c-Kit. Using combined techniques of anti-CD117 (c-Kit) immunolabeling, confocal imaging, and computational algorithms, we characterize the morphological features and spatial distribution of the c-Kit-expressing amacrine cells. Our results show that c-Kit-expressing amacrine cells are GABA-positive neurons with medium to wide dendritic fields that stratify within the specific strata in …

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The Power Of Positive Lesbian Representation In Television: How It Affects The Well-Being And Identity Formation Of Lgbtq+ Adults, Brittany Berry Dec 2025

The Power Of Positive Lesbian Representation In Television: How It Affects The Well-Being And Identity Formation Of Lgbtq+ Adults, Brittany Berry

University Honors Theses

To date, there are no studies which explore the effects that positively represented Black and lesbian characters in television have on LGBTQ viewers. Exposure to LGBTQ characters has the potential to validate LGBTQ identities and improve well-being. A comprehensive literature review and quantitative analysis using Żerebecki et. al.'s codebook reveals there are simply not enough characters depicted to provide such research. In an attempt to demonstrate the qualities possessed by positively portrayed Black, lesbian characters, this study analyses Taissa Turner from the hit series Yellowjackets available on the streaming network Paramount+.

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Human Evil (In The Weird), Lucas Ethridge Dec 2025

Human Evil (In The Weird), Lucas Ethridge

University Honors Theses

This paper examines a trending doom in speculative fiction: the post-human age. Many modern works have started to look past human civilization as humans surrender all hope and faith in a climate-doomed world. Honing in on core concepts in Weird fiction, this paper explores human merit through Old and New Weird. A good part spends time establishing the canon, looking at similar patterns across age, philosophy, war and genre. The chief question asks if humankind was ever worth saving.

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Capstone Reflection: Developing A Muslim Prayer App For Psu Students, Jeremiah Su Dec 2025

Capstone Reflection: Developing A Muslim Prayer App For Psu Students, Jeremiah Su

University Honors Theses

This thesis examines the development process of the Muslim Student Association (MSA) App, a computer science capstone project. The app strives to help the Muslim community at Portland State University (PSU) and the Portland area by consolidating essential information for prayers, such as local prayer times, nearby masjids, and the direction of Qibla. The team behind this project was developed by 6 computer science developers, a majority of whom were from the Muslim culture and background. This paper describes the entire capstone development process from the perspective of a developer who is not rooted in Muslim customs. It also describes …

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Child Assent Practices In Research: Improving Ethics, Decision-Making, And Inclusivity, David C. Coker, Ketaki Inamdar, Daniel F. Mccleary, Lesley Cottrell Dec 2025

Child Assent Practices In Research: Improving Ethics, Decision-Making, And Inclusivity, David C. Coker, Ketaki Inamdar, Daniel F. Mccleary, Lesley Cottrell

Journal of Educational Research and Practice

The following article addresses a conundrum: What if child assent in research were a fully informed, stand-alone process that empowered all children to discuss meaningfully, negotiate, and decide how and what the research experience would look like? Past research and practices suggest that child assent, when children (youths to 17-year-olds who have not been emancipated) agree to participate in research before, during, and after parents’ or guardians’ consent, is rife with problems that minimize informed participation and prize procedural ethics over true understanding of the processes and autonomous decision-making. Academic articles often lack details, as length requirements and brevity preclude …

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Estate Planning Techniques: Disclaimer-A Useful Post-Mortem Estate Planning Tool, Philip E. Heckerling Dec 2025

Estate Planning Techniques: Disclaimer-A Useful Post-Mortem Estate Planning Tool, Philip E. Heckerling

Tax Adviser

No abstract provided.

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Create @ State 2011, Arkansas State University - Jonesboro Dec 2025

Create @ State 2011, Arkansas State University - Jonesboro

Create@State

The proceedings book for 2011

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Enrolled Deeds As Records And Archives In Jamaica, Andrew Williams Dec 2025

Enrolled Deeds As Records And Archives In Jamaica, Andrew Williams

Journal of Contemporary Archival Studies

This paper examines the history of the enrolled deeds record series in Jamaica, from its creation in the mid-seventeenth century through to the present day. It is a critical examination of a single record series through colonialism and independence. It examines the purpose of deeds and the context in which deeds registries were created before examining the history of the series through the periods of slavery and emancipation. It examines in close detail the late nineteenth century, when the Island Record Office—which has custody of the enrolled deeds—was created and several other important changes happened. It situates the enrolled deeds …

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Restricted Word Order In Languages Without Overt Case Marking: Evidence From Modern Dialects Of Arabic, Mustafa Ahmed Al-Humari Dec 2025

Restricted Word Order In Languages Without Overt Case Marking: Evidence From Modern Dialects Of Arabic, Mustafa Ahmed Al-Humari

UB Journal for Humanities

The study examines the morphosyntactic strategies used in Arabic language to indicate grammatical functions (subject, object) within a sentence, comparing and contrasting modern dialects of Arabic, particularly Saudi Arabic, and Yemeni Arabic, with Standard Arabic. The empirical observation of the study is that, while Standard Arabic mainly relies on a case marking strategy to determine grammatical functions, the modern dialects of Arabic under investigation are incapable of employing this strategy. This incapability raises questions about how grammatical functions are indicated in the absence of overt case morphology in the mentioned dialects. The paper argues that the absence of overt case …

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The Syntax Of Verbless Sentences In Bisha Najdi Arabic, Aeshah Muqbil Saeed Almineeai Dec 2025

The Syntax Of Verbless Sentences In Bisha Najdi Arabic, Aeshah Muqbil Saeed Almineeai

UB Journal for Humanities

This study investigates the syntactic structure of verbless sentences in Bisha Najdi Arabic (henceforth BNA). It explores the different types of BNA verbless constructions, i.e., verbless constructions with nominal predicate, adjectival predicates and adverbial predicate. It argues for the nonverbal predicate analysis, as proposed by Benmamoun (2000, 2008), and extends the analysis to BNA verbless constructions within Chomsky's (1995) Minimalist Framework. In addition, the study argues that hnaak in similar constructions is a verb-like element, and accordingly, a syntactic analysis is provided for both BNA affirmative and negative hnaak-constructions. By investigating the syntactic structure of BNA verbless sentences, the study …

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Variations In Politeness Strategies Among Native Speakers Of Najdi Arabic And American English In Social Communication: A Cross-Cultural Study, Aeshah Muqbil Saeed Almineeai, Asseel Ali Alshahrani Dec 2025

Variations In Politeness Strategies Among Native Speakers Of Najdi Arabic And American English In Social Communication: A Cross-Cultural Study, Aeshah Muqbil Saeed Almineeai, Asseel Ali Alshahrani

UB Journal for Humanities

Uncovering what constitutes polite language in each culture and how certain expressions deemed acceptable in one society might be inappropriate in the other is the focus of politeness. Therefore, this study investigates the variations in communication strategies among speakers of Najdi Arabic, as spoken in Bisha City, and speakers of American English. The study basically explores how individuals from these distinct linguistic backgrounds respond to five different social scenarios. The study used qualitative approach to detect the responses of 15 speakers—11 Saudi Arabian natives and 4 Americans on some situations. Findings show there are some similarities in what may be …

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Exploring The Intricate Relationship Between Automation And Performance In The Saudi Public Sector., Saleh Hamed Alharbi Dec 2025

Exploring The Intricate Relationship Between Automation And Performance In The Saudi Public Sector., Saleh Hamed Alharbi

UB Journal for Humanities

Office automation immensely enhances the working environment. Widespread technological revolution shapes Human Resource Management (HRM) practice. The most important factor in decision-making is the information on which the decision is based. Detailed and accurate information prevents erroneous decisions. This study explores the impact of the automation of HR processes on organizational performance in the public sector. Three hundred and sixteen (316) employees from the University of Tabuk participated in the study. The study used smart Partial Least Squares–Structural Equation Model (smart PLS-SEM) to estimate the relationships between constructs. The results reveal that office automation has a direct impact on organizational …

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The Quest For Connection In A Cold And Isolated World: A Psychoanalytical Study On Edward Albee's 'The Zoo Story', Abdulmajeed Abdulqadir Saeed Alhanash Dec 2025

The Quest For Connection In A Cold And Isolated World: A Psychoanalytical Study On Edward Albee's 'The Zoo Story', Abdulmajeed Abdulqadir Saeed Alhanash

UB Journal for Humanities

This research paper explores the theme of connection in a cold and isolated world through a psychoanalytical lens. It specifically focusses on Edward Albee's one-act play, The Zoo Story, examining how the characters' struggles with loneliness, alienation, and detachment reflect the broader human condition. It illuminates the underlying psychological motivations, anxieties, and desires that shape their actions and relationships. The psychological approach is used to analyze the social isolation and loneliness of characters in the play. Analyzing this theme psychologically illuminates the factors contributing to Jerry’s sense of isolation: lack of meaningful social connections, societal pressures, and personal experiences that …

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Problems Of Faithfulness In The English Translation Of Tayeb Salih’S Masterpiece Season Of Migration To The North: Revisiting Equivalence Theory, Ali Albashir Mohammed Alhaj Dec 2025

Problems Of Faithfulness In The English Translation Of Tayeb Salih’S Masterpiece Season Of Migration To The North: Revisiting Equivalence Theory, Ali Albashir Mohammed Alhaj

UB Journal for Humanities

Translation is a bi-lingual communication activity that should convey the information similar to the original. Consequently, the translator's target is to be faithful to the original wording and maintain the essence of the source language (SL) when he/she conveys a text in the target language (TL). This study was conducted to cast a new light on the cultural problems encountered by Denys Johnson-Davis in his English translation of Tayeb Salih's Season of Migration to the North, specifically in terms of his faithfulness to the ST, and how these can be addressed from various theoretical and practical standpoints about the equivalence …

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Exploring The Impact Of Talent Management Strategies On Improving Healthcare Service: A Case Study On King Faisal Medical Complex In Taif, Wejdan Mabrook Abdullah Al-Otaibi, Osama Abdelmonge Yousef Akola, Sami Ahmed Saleh Alghamdi Dec 2025

Exploring The Impact Of Talent Management Strategies On Improving Healthcare Service: A Case Study On King Faisal Medical Complex In Taif, Wejdan Mabrook Abdullah Al-Otaibi, Osama Abdelmonge Yousef Akola, Sami Ahmed Saleh Alghamdi

UB Journal for Humanities

The current study aims to identify the role of talent management in improving the service of healthcare service. To achieve the objectives of the study, the researchers relied on the descriptive analytical approach. A questionnaire was administrated employees at King Faisal Medical Complex (KFMC) in Taif - Kingdom of Saudi Arabia. The researchers received back 230 responses. Results show that the respondents agreed highly on the imperative role of talent management, with an average score of 76.96%. There was a positive correlation was (r=0.4835), between the dimensions of talent management and the improvement of the healthcare service. The results also …

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Fostering Oral English Skills Beyond Formal Learning In Saudi Efl Setting, Ghazwan Mohammed Saeed Mohammed Dec 2025

Fostering Oral English Skills Beyond Formal Learning In Saudi Efl Setting, Ghazwan Mohammed Saeed Mohammed

UB Journal for Humanities

The increasing research on informal language learning illustrates awareness about out-of-class learning. This study aimed to explore how technological advances are being used informally to enhance EFL learners’ oral skills. The study was conducted at the University of Bisha, Saudi Arabia. Employing a survey, data were collected from 191 learners at the university level. The participants were male and female students who were enrolled at different colleges of the university. Findings revealed that learners frequently use a set of strategies for out-of-class oral skills enhancement. The listening and speaking strategies were quite similar, which indicated that learners were aware of …

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Ancient Chivalry And Modern Masculinity, Henry Jones Jones Dec 2025

Ancient Chivalry And Modern Masculinity, Henry Jones Jones

Arkansas Liberal Arts and Humanities Day

I’m dissecting toxic masculinity in society through the lens of chivalry, as shown in Sir Gawain and the Green Knight. Knights were held to a code of chivalry that they used to interact with others and to wage war, a code heavily on display within the text of Sir Gawain. I’ve expanded into the fields of psychology, biology, and warfare to determine if there is a link between ancient chivalry and how men act today.

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Religion: How Faith And Science Unite Society, James Tester Dec 2025

Religion: How Faith And Science Unite Society, James Tester

Arkansas Liberal Arts and Humanities Day

Over a billion people follow the modern Catholic church, yet one man, Dante, greatly shaped Catholicism as society now sees it today through his writings. Religion is central to humanity, influencing thousands of people’s lives every day, but it can be changed drastically by a new perspective. How, and why, does one person, or a group of people, completely alter a religion and its values? I am examining religion through texts such as Dante’s Inferno and theological studies to catch a glimpse of how societies shape religion and beliefs. Every religion has its own rules and structures, often contradictory to …

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“Leafing” Through Chinese Opera: Phytopoetics In The Peony Pavilion, Madison Bussell Escoto Dec 2025

“Leafing” Through Chinese Opera: Phytopoetics In The Peony Pavilion, Madison Bussell Escoto

Arkansas Liberal Arts and Humanities Day

Ornamental flowering plants have been instrumental symbols in literature across all times and cultures. I’m examining why flowers are such perceptual stimulants, sexual symbols, and literary agents. Through the lens of Harvard Divinity’s term “phytopoetics,” botany, and literary scholarship, I will look closely at this phenomenon in The Peony Pavilion, a Chinese opera from 1598. Exploring “the garden” as a place, I will present the embodied, sensory, and relational elements of the human-flower relationship using the striking visual of Tang Xianzu’s revolutionary production. Just as we perceive the costumes and makeup of the opera as giving traits to the characters, …

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Students’ Use Of Chatgpt As A Writing Tool, Hannah K. Young Dec 2025

Students’ Use Of Chatgpt As A Writing Tool, Hannah K. Young

Arkansas Liberal Arts and Humanities Day

Over the past decade, educational technology has drastically evolved. Generative artificial intelligence chatbots such as ChatGPT, developed by OpenAI, have recently become popular resources for students seeking academic support. While articles discuss whether students should use generative AI, little research exists on how students engage with it in academic settings. This study analyzes student interactions with ChatGPT, where participants enrolled in College English were tasked with writing a one-page essay. This decision aimed at providing a diverse range of students from different disciplines and skill sets, rather than a large group of English majors in a higher-level course. Without specific …

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Exculsivity Of Choice Of Court Agreements: Party Autonomy In Forum Selection, Mo Zhang Dec 2025

Exculsivity Of Choice Of Court Agreements: Party Autonomy In Forum Selection, Mo Zhang

University of Memphis Law Review

Choice of court agreements are contractual agreements where parties exercise autonomy to agree on a forum to which the parties are voluntarily subject to should a dispute arise from their commercial transactions or other civil relationships. Exclusivity is an issue concerning how a choice of court agreement is to be enforced. Presumption of exclusivity is a doctrine aimed at ensuring an effective enforcement of the agreement as such. Acceptance of the doctrine has become a growing trend internationally, as illustrated by the 2005 Hague Convention on Choice of Court Agreements. In American courts, choice of court agreements are generally presumed …

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Sexual Orientation, Rank, And Status, Duane Rudolph Dec 2025

Sexual Orientation, Rank, And Status, Duane Rudolph

University of Memphis Law Review

Dignity retains its ancient focus on rank and status. This Article, therefore, rejects the idea that we now live in the age of equal dignity, meaning equal rank and status for everyone. Rank underscores numbering, placement, and position in a predetermined hierarchy, and status underscores the power and privileges associated with each rank. Rank permits human beings to identify their preassigned location in the hierarchy, and status justifies assertions of rank since status governs the ancestral privileges, powers, and responsibilities attached to each rank. The Article relies on two constitutional cases, one before “dignity” and the other after. In 1986, …

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Empowering The People Of The Developing World Dec 2025

Empowering The People Of The Developing World

Vision and mission statements

No abstract provided.

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Cœur-Age, Andrew Pearson Dec 2025

Cœur-Age, Andrew Pearson

Philomathean

No abstract provided.

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2025 Editorial Board, Meredith Scheiner Dec 2025

2025 Editorial Board, Meredith Scheiner

Philomathean

No abstract provided.

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Back Matter, Meredith Scheiner Dec 2025

Back Matter, Meredith Scheiner

Philomathean

No abstract provided.

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All Of Us Live In Texas, But Our Friends Hang Their Hats In New Zealand, Augusta Arata, Irene L. Flores, Angel Castillo, Robert Hoilman, Donald D. Sanders Ii Dec 2025

All Of Us Live In Texas, But Our Friends Hang Their Hats In New Zealand, Augusta Arata, Irene L. Flores, Angel Castillo, Robert Hoilman, Donald D. Sanders Ii

Sociology and Anthropology Student Research - Archive

Cultural similarities and differences between New Zealand and Texas through an anthropological perspective. The zine focuses on cuisine, sports, consumerism, and lifestyle choices.

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