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Exploring Mediated Psychosocial Effects On Dating Violence Perpetration And Victimization In The Me & You Building Healthy Relationships Program For Middle School Students, Mike Henson-Garcia, Elizabeth R Baumler, Christine M Markham, Robert C Addy, Ross Shegog, Belinda Hernandez, Paula Cuccaro, Jeffery Temple, Susan Tortolero Emery, Melissa F Peskin Dec 2025

Exploring Mediated Psychosocial Effects On Dating Violence Perpetration And Victimization In The Me & You Building Healthy Relationships Program For Middle School Students, Mike Henson-Garcia, Elizabeth R Baumler, Christine M Markham, Robert C Addy, Ross Shegog, Belinda Hernandez, Paula Cuccaro, Jeffery Temple, Susan Tortolero Emery, Melissa F Peskin

Faculty, Staff and Student Publications

Teen dating violence (TDV) is a prevalent and injurious public health threat affecting adolescent populations across the globe. In response, a plethora of interventions have been developed and implemented with various effects emerging from evaluation studies of these prevention initiatives. The purpose of this study was to investigate whether attitudes toward sexting, gender-based norms toward violence, and constructive conflict resolution skills mediate the main effects of a TDV intervention. Specifically, this study leverages data from the original efficacy trial of the


Imaging Reactive Oxygen Species With L-012 Reveals Neutrophil Extracellular Trap Formation In Pancreatic Ductal Adenocarcinoma, Angisha Basnet, Kaitlyn M Landreth, Michael Sestito, Kristen Ranson, Seth T Gammon, David Piwnica-Worms, Brian A Boone, Tracy W Liu Dec 2025

Imaging Reactive Oxygen Species With L-012 Reveals Neutrophil Extracellular Trap Formation In Pancreatic Ductal Adenocarcinoma, Angisha Basnet, Kaitlyn M Landreth, Michael Sestito, Kristen Ranson, Seth T Gammon, David Piwnica-Worms, Brian A Boone, Tracy W Liu

Faculty, Staff and Student Publications

Neutrophils, key effector cells of the innate immune system, combat pathogens through mechanisms including the production of reactive oxygen species (ROS) and the release of neutrophil extracellular traps (NETs). While these responses are critical for host defense, prolonged elevation of ROS and dysregulated NETosis mediated by neutrophils have been implicated in autoimmune diseases, chronic inflammation, and cancer. In pancreatic ductal adenocarcinoma (PDAC), a highly aggressive and inflammatory malignancy, an increase in neutrophils infiltrating the tumor microenvironment promotes cancer progression and metastasis through increased ROS production and NET release. Using bioluminescence imaging with the reporter L-012 and NET assays, we assessed …


Precise Diagnosis Of Small Invasive Pulmonary Nodules Driven By Single-Cell Immune Signatures In Peripheral Blood, Yang Xia, Yin Zhu, Sai Zhang, Mo Zhou, Jiaqi Zhou, Guanxin Xu, Baiqin Zhao, Guofei Zhang, Qiyuan Wang, Bin Wang, Zexin Chen, Hongyu Shi, Xiuning Le, Tony Mok, Wei Chen, Junqiang Fan, Weiwei Yin, Wen Li Dec 2025

Precise Diagnosis Of Small Invasive Pulmonary Nodules Driven By Single-Cell Immune Signatures In Peripheral Blood, Yang Xia, Yin Zhu, Sai Zhang, Mo Zhou, Jiaqi Zhou, Guanxin Xu, Baiqin Zhao, Guofei Zhang, Qiyuan Wang, Bin Wang, Zexin Chen, Hongyu Shi, Xiuning Le, Tony Mok, Wei Chen, Junqiang Fan, Weiwei Yin, Wen Li

Faculty, Staff and Student Publications

Early detection of lung cancer is crucial for improving patient outcomes. However, accurately diagnosing invasive pulmonary nodules and predicting tumor invasiveness remain major clinical challenges. Given the established role of immune dysfunction in cancer development, we hypothesize that peripheral immune profiling could provide a strategy for managing pulmonary nodules. In this multi-center, prospective study, we combine peripheral immune profiling via mass cytometry with machine learning algorithms to develop an integrated pulmonary nodule management platform. This platform accurately distinguishes invasive from non-invasive pulmonary nodules (AUC = 0.952), outperforming established clinical and radiomics-based models. Furthermore, it effectively predicts tumor invasiveness, differentiating minimally …


The Impacts Of The St. Louis Guaranteed Basic Income Program On Quality Of Life, Hannah Allee, Grace Anderson, Rachel Barth, Laura Brugger, Meihsi Chiang, Alex Dobill, Leah Hamilton, Ashley Moore, Liz Rolf, Stephen Roll, Guangli Zhang Dec 2025

The Impacts Of The St. Louis Guaranteed Basic Income Program On Quality Of Life, Hannah Allee, Grace Anderson, Rachel Barth, Laura Brugger, Meihsi Chiang, Alex Dobill, Leah Hamilton, Ashley Moore, Liz Rolf, Stephen Roll, Guangli Zhang

Center for Social Development Research

How does guaranteed basic income influence recipients’ quality of life?

In late 2023, the City of St Louis launched a pilot program providing $500 a month for 18 months to more than 500 low-income St. Louis households with children. Researchers from the Center for Social Development and the Brown School Evaluation Center conducted a mixed-methods evaluation of the program, tracking recipients’ journeys over the pilot’s duration. This brief presents findings on the effects of the St. Louis Guaranteed Basic Income Program on participants’ quality of life, including the ability to meet daily living expenses, the well-being of participants and their …


Experiences And Perceptions Of Patients, Caregivers, And Healthcare Professionals With Long-Acting Injectable Antipsychotics For The Treatment Of Schizophrenia: Qualitative Results From The Multinational Advance Study, Martha Sajatovic Dec 2025

Experiences And Perceptions Of Patients, Caregivers, And Healthcare Professionals With Long-Acting Injectable Antipsychotics For The Treatment Of Schizophrenia: Qualitative Results From The Multinational Advance Study, Martha Sajatovic

Faculty Scholarship

Introduction: Schizophrenia imposes a substantial burden on individuals and society. Long-acting injectable antipsychotics (LAIs) improve adherence and reduce relapse and hospitalization rates compared with oral treatments for schizophrenia, yet LAI use varies globally. The qualitative interview portion of the global Attitudes DriVing regional differences in long-acting injectable ANtipsychotic utilization for schizophrenia among healthcare professionals (HCPs), patients, and CaregivErs (ADVANCE) study explored the patient journey from schizophrenia diagnosis to treatment, treatment goals, and experiences and perspectives on LAIs that may influence their use. Methods: ADVANCE included HCPs, patients, and caregivers from Australia, Canada, China, Germany, Israel, Spain, South Korea, and the …


Increasing Colon Cancer Screening Completion Rates Utilizing Patient Navigation In Primary Care: A Quality Improvement Project, Anya C. Pennycooke Dec 2025

Increasing Colon Cancer Screening Completion Rates Utilizing Patient Navigation In Primary Care: A Quality Improvement Project, Anya C. Pennycooke

Electronic Theses and Dissertations 2020 - Present

Colorectal cancer is the second leading cause of cancer-related deaths in the United States. It is highly preventable through routine screening and early detection, yet national data indicate that one in three eligible adults remains unscreened. The purpose of this Quality Improvement (QI) project was to increase colon cancer screening completion rates by implementing a patient navigation program. Kristen Swanson’s Theory of Caring guided the intervention by promoting patient-centered communication. W. Edwards Deming’s Plan-Do-Study-Act (PDSA) model provided the framework for this approach. Patients aged 45-75 years due for colon cancer screening were identified using the electronic health record (EHR) in …


Towards A Typology Of Mental Health Crisis Care Services For Children And Young People In England And Wales: A Cross-Sectional Survey And Analysis Of Implementation Practices, Clare Bennett, Claire Fraser, Ben Hannigan, Leanne Sawle, Jessy Williams, Aled Jones, Steven Pryjmachuk, Mair B. Elliott, Martin Elliott, Nicola Bennett, Euan Hails, Iain Mcmillan, Rachael Vaughan Dec 2025

Towards A Typology Of Mental Health Crisis Care Services For Children And Young People In England And Wales: A Cross-Sectional Survey And Analysis Of Implementation Practices, Clare Bennett, Claire Fraser, Ben Hannigan, Leanne Sawle, Jessy Williams, Aled Jones, Steven Pryjmachuk, Mair B. Elliott, Martin Elliott, Nicola Bennett, Euan Hails, Iain Mcmillan, Rachael Vaughan

School of Nursing and Midwifery

Background: The mental health and wellbeing of children and young people is a global concern. Alongside approaches emphasising mental health promotion in schools, communities and in the home, many countries are also investing in crisis services. These aim to meet the needs of young people experiencing acute psychosocial distress. A recent synthesis of the international evidence found a paucity of research in this area. This study sought to address this gap while simultaneously situating the findings within the international context and drawing out implications for policymakers and practitioners. Methods: A cross-sectional study aiming to describe and map approaches to the …


Time-Resolved Ultrafast Infrared Spectroscopic Interrogation Of Intramolecular Reaction Coordinates, Valerie Winkler Dec 2025

Time-Resolved Ultrafast Infrared Spectroscopic Interrogation Of Intramolecular Reaction Coordinates, Valerie Winkler

Arts & Sciences Graduate Student Theses and Dissertations

Light-induced chemical transformations are practical across many chemical and biological systems. From intramolecular hydrogen-bonding coordinates to reactions which alter the carbon framework of a molecule, the application of light can induce conformational changes that can subsequently be harnessed for a variety of tasks. However, molecular-level mechanistic insight about photo-induced chemical reactions remains difficult to acquire using current methodologies. In this dissertation, several intramolecular reactions are investigated and characterized, ranging from ground- and excited-state intramolecular proton transfers to the photochemical synthesis of a complex organic cyclization structure. The reaction coordinates are directly interrogated by utilizing ultrafast infrared spectroscopic techniques, such as …


Chimes: December 8, 2025, Calvin University Dec 2025

Chimes: December 8, 2025, Calvin University

Chimes

Women's volleyball's memorable season ends in the DIII quarterfinals by Zach Kern

Facilities expands recycling program on campus by Ian Tjoelker

A history of the liberal arts at Calvin: 1890s to today by McKenna Wilkinson

Christmas beyond Calvin: Letters to Santa by Ellery Johnson

"Energy and vision": Calvin's Black Student Union by Jorie Cho

Running with Sophie by Evangeline Anga

Students prepare for upcoming Fall Film & Media Showcase by Ashley Hamons


Spike Timing Depended Plasticity Produces Unsupervised Learning Of Synergistic Muscle Feedback In A Synthetical Neural Network, Mark Allen Pupkiewicz Dec 2025

Spike Timing Depended Plasticity Produces Unsupervised Learning Of Synergistic Muscle Feedback In A Synthetical Neural Network, Mark Allen Pupkiewicz

Dissertations and Theses

This study investigates how type Ia feedback from muscle spindles can be organized into groups representing agonistic muscle pairs through Spike Timing Dependent Plasticity (STDP). A single degree of freedom joint is actuated with four biologically modeled muscles forming two agonistic pairs. In order to emulate the sensory dynamics of biological muscle spindles, sensors in the model record the active length and velocity states of each muscle, the two primary factors eliciting type Ia afferent responses. In biological networks, synapses from Ia sensory neurons frequently activate interneurons representing agonistic muscle sources. This research investigates whether this organization can emerge in …


You Have To Cut&Walk Before You Can Cut&Run: Regulation Of Gene Expression By The Vitamin D Receptor (Vdr) In The Annual Killifish, Austrofundulus Limnaeus, Rosalia Tanori Dec 2025

You Have To Cut&Walk; Before You Can Cut&Run;: Regulation Of Gene Expression By The Vitamin D Receptor (Vdr) In The Annual Killifish, Austrofundulus Limnaeus, Rosalia Tanori

Dissertations and Theses

The annual killifish, Austrofundulus limnaeus, found in ephemeral ponds in South America, possesses a remarkable ability to survive extended periods without water and oxygen. This ability is associated with developmental dormancy known as diapause. Numerous genetic and environmental factors influence the entry into diapause and tolerance to environmental stress. Among these is vitamin D3 signaling mediated by the vitamin D receptor (VDR), which plays a crucial role in regulating entry into diapause and the continuous development of an embryo in a temperature-dependent manner. Vitamin D3 signaling influences a variety of physiological processes in vertebrates. While extensively characterized in mammalian …


Comprehensive Cmr Evaluation Including 4d Flow-Derived E/A Vorticity Ratio In Overweight Adults With And Without Type 2 Diabetes Mellitus, Sungho Park, Erin K Englund, Takashi Fujiwara, Daniel Enge, Michal Schäfer, Jochen Gerstner Saucedo, Ethan W Clark, Layla A Abushamat, Rebecca L Scalzo, Brian Fonseca, Kendall S Hunter, Mary D Sammel, Judith G Regensteiner, Jane E B Reusch, Alex J Barker Dec 2025

Comprehensive Cmr Evaluation Including 4d Flow-Derived E/A Vorticity Ratio In Overweight Adults With And Without Type 2 Diabetes Mellitus, Sungho Park, Erin K Englund, Takashi Fujiwara, Daniel Enge, Michal Schäfer, Jochen Gerstner Saucedo, Ethan W Clark, Layla A Abushamat, Rebecca L Scalzo, Brian Fonseca, Kendall S Hunter, Mary D Sammel, Judith G Regensteiner, Jane E B Reusch, Alex J Barker

Faculty, Staff and Students Publications

Aims: This study aimed to assess the impacts of overweight and type 2 diabetes (T2D) on early hemodynamic and left ventricular (LV) changes using comprehensive cardiovascular magnetic resonance imaging (CMR) in three age- and sex-similar groups: lean individuals (LI group), BMI-similar overweight controls without T2D (CWO group) and overweight individuals with uncomplicated T2D (T2D group).

Methods: Middle-aged participants included 13 in the LI group, 37 in the CWO group, and 28 in the T2D group. Baseline assessments included cardiac and vascular function measured by CMR, thoracic echocardiography, insulin sensitivity, clinical measures, and cardiorespiratory fitness. 4D flow CMR was used to …


Library Guides For Graduate Students: A Content Analysis, Maria Kiriakova, Junli Diao, Joan Kelly Castro Dec 2025

Library Guides For Graduate Students: A Content Analysis, Maria Kiriakova, Junli Diao, Joan Kelly Castro

Journal of Graduate Librarianship

This study looked at 117 Association of Research Libraries (ARL) academic library websites and identified 48 library guides that consider graduate students in general as their target audience. The broad and systematic content analysis of these library guides resulted in the discovery of four different types, which we categorized as Checklist, Orientation Module, Directory, and Comprehensive. We identify and describe content patterns that address the different roles graduate students might play as advanced library users, novice researchers, and teaching assistants/instructors. Academic librarians who have already created library guides for graduate students could use the results of …


Social Development Dynamics Of Students In Inclusive Education In Indonesia, Nur Hidayat Nh Dec 2025

Social Development Dynamics Of Students In Inclusive Education In Indonesia, Nur Hidayat Nh

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This narrative review analyses the social development of students with special needs in Indonesian inclusive schools by synthesising five high-quality empirical studies (indexed SINTA 1–3) published between 2018 and 2023. Addressing three research questions, the synthesis reveals heterogeneous and generally limited social development trajectories shaped primarily by ecological interactions rather than inherent disability characteristics. Key barriers include symbolic inclusion, inadequate teacher training in multimodal strategies, low peer acceptance, and systemic resource deficits, whereas facilitators encompass contextualised multimodal communication, active family involvement, and supportive institutional leadership. Effective interventions depend on coordinated teacher–parent–peer triangulation, leveraging local sign language, structured peer-mediated activities, and …


Choosing The Best Entity For Investments Trading After Understanding The Tax Limitations And Restrictions, Ray A. Knight, Joseph Lakatos Dec 2025

Choosing The Best Entity For Investments Trading After Understanding The Tax Limitations And Restrictions, Ray A. Knight, Joseph Lakatos

DePaul Business & Commercial Law Journal

The trading of various securities is subject to market rules. However, when securities trading is completed within a business entity, the entity is subject to tax limitations and restrictions. The tax benefits cannot be the dominant purpose for the entity structure; economic substance including profit motive and business purpose for each transaction must be able to be shown.

The trading of investment securities must be housed in the right entity to gain the best economic results as well as to minimize the tax burden. The entity selection process must first consider the characteristics and nature of the securities (e.g., currencies, …


Immeasurable Halls And Dreamlike Forms: Tracing The Caves Of Cheddar Gorge Throughout Tolkien’S Legendarium (And Beyond), Kristine Larsen Dec 2025

Immeasurable Halls And Dreamlike Forms: Tracing The Caves Of Cheddar Gorge Throughout Tolkien’S Legendarium (And Beyond), Kristine Larsen

Journal of Tolkien Research

Cheddar Gorge (Mendip Hills, Somerset County, southwest England) is home to extensive cave systems carved into ancient limestone. Two of the most picturesque, Gough’s Cave and Cox’s Cave, are among the most important geological tourist attractions in England. Among the caves’ many enthusiasts was J.R.R. Tolkien, who first visited the site in 1916 while on his honeymoon and later in 1940 on a family vacation during his early work on The Lord of the Rings. As he noted in a 1971 letter these two visits (in particular, his earlier memories of the caves before their unfortunate commercialization) spawned the …


Tax Clinic, Albert H. Cohen Dec 2025

Tax Clinic, Albert H. Cohen

Tax Adviser

No abstract provided.


Northern Illinois University’S Child Development And Family Center “Diversity Bookshelf” Audit, Marinelle Ortega Dec 2025

Northern Illinois University’S Child Development And Family Center “Diversity Bookshelf” Audit, Marinelle Ortega

Honors Capstones

A classroom bookshelf diversity audit allows students to find “mirrors, windows, and glass sliding doors” in the books they choose to read. This metaphor means students will find their identities reflected in books (mirrors), learn about other’s identities (windows), and finally, be put into other perspectives (glass sliding doors). In this diversity audit, a selection of 100 books at the Child Development and Family Center at Northern Illinois University were read and analyzed. Findings showed diverse representation for race, ethnicity, and family type. However, showed a need for books containing content with religion, disability, and linguistic diversity, as most books …


Southern Adventist University Commencement Winter 2025, Southern Adventist University Dec 2025

Southern Adventist University Commencement Winter 2025, Southern Adventist University

Commencement Programs

Program for Southern Adventist University Winter 2025 graduation. The commencement service took place on December 18, 2025 at 7 pm in Iles Physical Education Center.


French 124 Assignment: Film Review, Jovensel Ngamaleu Dec 2025

French 124 Assignment: Film Review, Jovensel Ngamaleu

Open Educational Resources

This assignment will help students discuss a film by focusing on cinematographic and narrative techniques as well as the personalities and worldviews of the main characters. Students will thus be able to develop their critical thinking and analytical skills.


Engr 204 – Electrical Circuits Project Assignment: Exploring A Key Concept From The Textbook, Liubov Kreminska Dec 2025

Engr 204 – Electrical Circuits Project Assignment: Exploring A Key Concept From The Textbook, Liubov Kreminska

Open Educational Resources

This assignment requires students to select a major concept from the ENGR 204 Electrical Circuits textbook and explore it through historical research, conceptual explanation, problem-solving, and real-world application. The project is structured to promote understanding through multiple means of representation, engagement, and expression, following Universal Design for Learning (UDL) principles. Students will describe the history and importance of the chosen concept, explain its main ideas using written or visual aids, solve representative and advanced problems related to the topic, and demonstrate how the concept appears in real-world engineering contexts. The submission must include clearly labeled sections, supporting visuals or simulations, …


Engr 204: 8-Week Op-Amp Major Project Series, Liubov Kreminska Dec 2025

Engr 204: 8-Week Op-Amp Major Project Series, Liubov Kreminska

Open Educational Resources

This submission outlines a collection of electronic design projects that can be completed within an 8-week timeframe, progressing from beginner-friendly circuits to advanced real-world applications involving op-amp design. Each project includes a week-by-week plan, required equipment, and key technical challenges. Through these projects, students gradually develop competence in signal processing, circuit stability, noise reduction, calibration, filter design, audio electronics, and bio-signal amplification. The structured timeline ensures systematic learning while allowing hands-on experimentation, troubleshooting, and refinement. The projects serve both as academic exercises and as practical foundations for more advanced electronic system design.


Arabic Around Us: Exploring Everyday Life Group Project, Bret Windhauser Dec 2025

Arabic Around Us: Exploring Everyday Life Group Project, Bret Windhauser

Open Educational Resources

Students will work in small groups to create a comprehensive and engaging project that explores a particular aspect of everyday life in an Arabic-speaking country. This could include food, traditions, daily routines, or an introduction to the language itself. By the end of the assignment, students will demonstrate their understanding of Arabic vocabulary, grammar, and culture through a creative project.


French 123 Assignment: Group Project, Jovensel Ngamaleu Dec 2025

French 123 Assignment: Group Project, Jovensel Ngamaleu

Open Educational Resources

This assignment is a way to engage with the real world through the practice of French in various areas of everyday life, in order to improve oral and written language skills.


Understanding Enso Through Mathematical Models, Maria I. Sanchez Muniz Dec 2025

Understanding Enso Through Mathematical Models, Maria I. Sanchez Muniz

Open Educational Resources

This assignment introduces students to conceptual models of the El Niño–Southern Oscillation (ENSO) and guides them through a structured investigation of their physical and mathematical foundations. Students analyze the recharge–oscillator and delayed–oscillator frameworks, explore how differential equations capture ocean–atmosphere interactions, and evaluate parameter-driven changes in oscillatory behavior. A key component of the work is the guided use of generative AI as a research tool: students employ AI models to locate peer-reviewed literature, interrogate model extensions, and refine their understanding of complex mechanisms, while synthesizing all final explanations in their own words. By blending classical climate modeling with modern AI-supported inquiry, …


Flm315.1.1 Creative Brief Example 2, Sae University College Dec 2025

Flm315.1.1 Creative Brief Example 2, Sae University College

Exemplars

A Creative Brief exemplar submitted as a component of Project 1 in FLM315 Client Based Productions.


Iphone-Based Image Refocusing, Katie Jeong, Daniel Niu Dec 2025

Iphone-Based Image Refocusing, Katie Jeong, Daniel Niu

Electrical and Systems Engineering Capstone Design Projects

In this project, we show that we can change the focus of a picture after we take it by using real optical physics instead of fake software blur. Modern phones try to create “portrait mode” effects, but those results are often not physically correct. Our approach uses multiple photos taken from slightly different positions to figure out the directions that light rays came from in the scene.

To collect the photos, we move an iPhone sideways on a slider in small, precise steps. Since we know exactly how far the phone moved for each picture, we can track how objects …


The Importance Of A Pressure Injury Prevention Program In Acute Hospital Settings, Sarah Orial Dec 2025

The Importance Of A Pressure Injury Prevention Program In Acute Hospital Settings, Sarah Orial

Student Scholarly Projects

Practice Problem: The identified practice problem for this project was the lack of a standardized pressure injury prevention program in a 350-bed acute care hospital. The lack of a standard program could be leading to increased hospital-acquired pressure injuries. PICOT: In adult inpatients in a medical/surgical unit (P), does the implementation of a standard unit-based pressure injury prevention program (I) compared to the current practice (C) increase the percentage of nursing skin risk assessment documentation (O) over a 10-week period (T)?

Evidence: The literature supports the development of standard pressure injury prevention programs and continuing education to …


Fall Recital: Community School For The Arts; December 7, 2025, Illinois State University School Of Music Dec 2025

Fall Recital: Community School For The Arts; December 7, 2025, Illinois State University School Of Music

School of Music Programs

This is the eighty-sixth program of the 2025-2026 season.

Kemp Recital Hall

December 7, 2025

Sunday Morning

11:00 a.m.


Bayesian Learning To Reduce Cardiac Risk Of Patients With Locally Advanced Non-Small Cell Lung Cancer Based On Personalized Radiation Therapy Prescription, Ruitao Lin, Mei Chen, Xiaodong Zhang, Tianlin Xu, Ting Xu, Rachel C Maguire, Kelsey L Corrigan, Efstratios Koutroumpakis, Joe Y Chang, Steven H Lin, Aileen B Chen, Quynh-Nhu Nguyen, Saumil J Gandhi, Matthew S Ning, Julianna Bronk, Stephen Chun, Ali Ajdari, Joshua S Niedzielski, Jinzhong Yang, Xinru Chen, Tinsu Pan, Qing H Meng, Anne S Tsao, Anita Deswal, Radhe Mohan, Zhongxing Liao Dec 2025

Bayesian Learning To Reduce Cardiac Risk Of Patients With Locally Advanced Non-Small Cell Lung Cancer Based On Personalized Radiation Therapy Prescription, Ruitao Lin, Mei Chen, Xiaodong Zhang, Tianlin Xu, Ting Xu, Rachel C Maguire, Kelsey L Corrigan, Efstratios Koutroumpakis, Joe Y Chang, Steven H Lin, Aileen B Chen, Quynh-Nhu Nguyen, Saumil J Gandhi, Matthew S Ning, Julianna Bronk, Stephen Chun, Ali Ajdari, Joshua S Niedzielski, Jinzhong Yang, Xinru Chen, Tinsu Pan, Qing H Meng, Anne S Tsao, Anita Deswal, Radhe Mohan, Zhongxing Liao

Faculty, Staff and Student Publications

Purpose: Radiation-induced heart damage is a significant concern in the treatment of non-small cell lung cancer (NSCLC) that can have debilitating or life-threatening consequences. Current strategies focus on minimizing heart exposure, but individual susceptibility varies. Existing evidence also suggests that a uniform "one-size-fits-all" dosimetric constraint for the heart may not be optimal for all patients.

Methods and materials: We developed a prospective study using Bayesian continuous learning and adaptation to develop a framework for personalized adaptive radiation treatment (PART) to reduce cardiovascular adverse events among patients with locally advanced NSCLC. The trial includes a Bayesian personalized risk prediction model to …