Digital Commons Network^™

The Pathophysiological Role Of Mitochondrial Acid-Sensing Ion Channel 1a In Hypoxic Pulmonary Hypertension, Megan N. Tuineau

Biomedical Sciences ETDs

Pulmonary hypertension (PH) is characterized by increased pulmonary arterial constriction, pulmonary arterial remodeling, and right ventricular dysfunction. While metabolic and mitochondrial derangements are increasingly recognized as central pathogenic features, the underlying mechanisms and effectors are not yet fully understood. Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel involved in the development of chronic hypoxia (CH)-induced PH. ASIC1a represents a potential candidate involved in metabolic-mitochondrial dysfunction, as metabolic byproducts can act as ligands for ASIC1a. Additionally, ASIC1a has recently been identified as a mitochondrial ion channel involved in neuronal death following oxidative stress. Therefore, we hypothesize that ASIC1a functions …

Grappling With Parenthood In 2025, Elisa Muyl

Capstones

In 2024, I became a parent for the first time. Within the first year of my child's life, president Trump was elected for a second term and came into office on the back of a right-wing project to “restore” the American family as the central unit of American life. I knew instinctively that the values and policies this project espoused would not work for my family or many others. At the same time, I was grappling with a profound sense of social alienation and the lack of structural support for new parents, exacerbated by the way that community is sustained …

“Comenzando De Nuevo”: Los Niños Migrantes Enfrentan Inestabilidad En Las Escuelas De Nyc, Adelina Romero

Capstones

This article documents how housing instability and frequent shelter relocations are disrupting the education of migrant children in New York City public schools. Through in-depth reporting centered on a Venezuelan family living in a Midtown shelter, as well as interviews with teachers, librarians, and advocates, the project demonstrates how frequent moves lead to reduced enrollment, academic delays, and emotional strain among English Language Learners. The reporting presents individual experiences within broader citywide trends, such as declining school enrollment and gaps in mandated services for multilingual students. As schools struggle to provide adequate instruction, public libraries have emerged as one of …

Solicitantes De Asilo Enfrentan Audiencias Sin Abogados Ante Fallas En La Ayuda Legal De Nyc, Nicol V. Leon Arge

Capstones

Este reportaje examina cómo las fallas en el sistema de asistencia legal de la ciudad de Nueva York están dejando a personas solicitantes de asilo enfrentar la corte de inmigración sin representación legal, lo que incrementa su riesgo de detención y deportación. A través de los casos de tres mujeres de Ecuador y Venezuela, el texto documenta cómo las barreras idiomáticas, la sobrecarga de las organizaciones sin fines de lucro y las limitaciones de los programas financiados por la ciudad hacen que el acceso a abogados pro bono sea inestable o inalcanzable. Pese a las iniciativas anunciadas por la administración …

The Remnants Of Nyc's Asylum Shelters, Charles Finnerty

Capstones

Since the spring of 2022, over 200,000 migrants and asylum seekers have arrived in New York City. For three years, the Eric Adams administration’s response shifted constantly, from welcoming new arrivals with open arms, to clashing with the Biden White House over federal support, to collaborating with the Trump administration’s mass deportation regime

Behind all these headlines and political fights, the city’s outer borough neighborhoods have absorbed new arrivals in school systems, gig work economies and over 150 shelters. Local government and corporate news media have largely failed to inform the public about the city's shelter program, allowing confusion and …

A Phenomenological Study Of The Lived Experiences Of Implementing An Education Model From School Leaders’ Perspectives, Jackie Marie Cusimano Phd

Teacher Education, Educational Leadership & Policy ETDs

A high school science teacher asked the question, “Why not make every class an elective?” He noticed that when his high school students were required to take a course, such as biology, the attendance and participation lacked when compared to his elective course of forensic biology. Both classes covered the same science standards. This question led him to applying for a public charter license and ultimately opening the first Choice Charter School in Albuquerque, New Mexico, in 2014. Choice Charter Schools follow the created Choice Charter Education Model, which is based on William Glasser’s Choice Theory (Glasser, 1998). Since the …

Despite Successful Lawsuits And Investigations, Kensington Grocery Stores Still Deny Workers Legal Wages, Tareq Saghie

Capstones

This article looks at three grocery stores in Kensington, Brooklyn that continue to pay immigrant workers below legal wages despite courts and the Department of Labor penalizing them for it repeatedly. The reporting speaks to the ineffectiveness of the law at deterring labor violations, the commonality of wage theft in New York's grocery stores, and the impacts it has on workers.

https://medium.com/@tareqsaghienyc/despite-successful-lawsuits-and-investigations-kensington-grocery-stores-still-deny-workers-legal-a332c980a1cb

San Mateo County’S Digital Jail Mail Sparks Reckoning Over Private Data, Juan A. Lasso

Capstones

This capstone examines privacy and data risks embedded in digital communication systems used in U.S. correctional facilities. As private vendors introduce tablets, kiosks, and mail digitization services, these technologies enable widespread surveillance and data collection of incarcerated people and their loved ones. The project explores how these systems track and analyze digital footprints in ways that challenge established legal and ethical expectations around privacy. It documents the personal impact on loved ones of people currently or formerly incarcerated in San Mateo County. The reporting centers on the California county jail where a civil rights lawsuit is pending over the mail …

A Halloween Decoration’S Scary Implications For Real Bats, Coralie Carlson

Capstones

This investigative article examines the online illegal trade of taxidermied bats and how the sales are threatening one particularly showy species: the painted woolly bat.

My OSINT research shows where the bats are still sold – from Amazon to independent websites offering bulk orders – and tracks the sellers and buyers, while weaving in the scientific and cultural history this little-known colorful bat and the conservationists’ race against time to protect them.

The very existence of the painted woolly bat is threatened by Americans who want to display the dead bats in their homes as spooky decorations. Researchers (including a …

Inside Tv’S Reckoning With Writing About Race, Anushka Dakshit

Capstones

In the face of rollbacks in DEI initiatives across the entertainment industry, television writers, producers, and critics discuss how racial representation behind the scenes can impact nuanced storytelling in front of the camera. In the early 2010s Lena Dunham's "Girls" received criticism for in the early 2010s for its lack of racial representation. In 2025, "Southern Fried Rice," produced by Keke Palmer, received controversy for its lack of sensitivity towards the representation of Black women. Critics, writers, and cultural strategists weigh in on what authentic representation looks like throughout all of the stages of the television development process. Link to …

Security Blanket: An Idea Of "Home" Across The Housing Spectrum, Willa D. Odefey

Capstones

Security Blanket: an idea of "home" across the housing spectrum addresses the logistical and emotional gaps left by policy-makers who prescribe a one-size-fits-all approach of housing to New York City’s houseless crisis. Independent living can be a major adjustment for people who have never lived on their own (eg. lived with parents, were formerly incarcerated, were in long-term hospital care), and shelters do not adequately prepare residents for the life-building steps after move-out. I asked New Yorkers experiencing homelessness where they are now, what home means to them, and what it would or has taken to ground themselves as they …

New Yorkers Training, Mobilizing To Protect Immigrants As Federal Crackdown Intensifies, Cristina Ledra, Andrew Serulneck

Capstones

As the Trump administration escalates deportation efforts nationwide, New York City is bracing for increased enforcement, with advocates warning that fear of deportation raids is already reshaping daily life for immigrant communities. New York protesters have not yet faced the most severe federal charges following high-profile confrontations, as protesters have in other states around the country. And the federal cases are largely falling apart and not resulting in trials or convictions. Despite the legal threat, some advocates see the moment as galvanizing.

https://docs.google.com/document/d/e/2PACX-1vQrUcmMi4XgxnkjMV-h58Cp3RTxfmIEt95H79uo7CDFlYD5lo59QylxoWozHJhBhlxHCzA98XHnwX7-/pub

The Box Office Keeps Disappointing. Indie Movie Theaters Keep Selling Tickets Anyway., Ella Feldman

Capstones

It’s been a tough five years at the box office, which has yet to recover from the impact of COVID-19 and the explosion of streaming options. But across the country, independent movie theaters have managed to buck the trend, according to industry data and interviews with theater operators. This feature story explores how indie cinemas have staged their post-pandemic comebacks.

Boeing Turns It Around, How A Change In Leadership Impacted An Industry, Fenix Suriel

Capstones

Boeing’s post McDonnell Douglas merger saw a shift from engineering-led decision-making to shareholder-driven priorities. This change is at the root of major safety failures, production issues, and ripple effects across the aviation labor market and supply chain. The appointment of CEO Kelly Ortberg, an engineer with deep aerospace experience, marked a turning point as he emphasized safety, transparency, training, and cultural reform, including mandatory safety systems and stricter competency standards. Boeing has shown signs of recovery through improved earnings, rising stock value, renewed FAA trust, and increased industry confidence. Though the company has not fully regained its pre-pandemic standing, experts …

How Armenia And Azerbaijan Are Lobbying For Influence In D.C., Gibran C. Boyce, Dawn Kikel

Capstones

In the wake of President Trump taking office, foreign government agencies and U.S.-based non-profits serving Armenian and Azerbaijani interests have been hiring lobbyists in Washington, D.C. as part of their concerted efforts to curry favor, gain influence, and seek policy changes that would benefit the rival post-Soviet nations.

Defiance Through Noise, Tyler Paz

Capstones

Defiance Through Noise analyzes the eviction of Punk HQ from 39 Eldridge Street within the broader history of punk-led, DIY, and squatted spaces in New York City. Using court records, historical context, and firsthand accounts from organizers, former nonprofit workers, and participants, the project examines Punk HQ as both a community space for marginalized youth and a continuation of Lower East Side squatting traditions from the 1970s and 1980s. The reporting situates its closure within intersecting forces of government disinvestment, housing policy, post-pandemic economic pressures, and the nonprofit industrial complex that have contributed to the decline of autonomous cultural spaces. …

Beyond The Model Minority: South Asian New Yorkers Confront Poverty, Mizuki Uchiyama

Capstones

This capstone project examines poverty among South Asian immigrants in New York City, challenging the “model minority” myth that portrays Asian Americans as uniformly successful. Through a reported NY1 television news package and accompanying written narrative, the project highlights how language barriers, economic insecurity and limited access to public benefits shape daily life for many immigrant families in Queens.

Reporting from the South Asian Council for Social Services (SACSS) in Flushing, the story connects individual experiences in workforce and sewing programs to broader data showing that Asian New Yorkers experience poverty at rates comparable to Black and Latino residents, with …

Building Another World, Christopher Edwards

Capstones

"Another World" is a mutual aid hub in Crown Heights, Brooklyn. The space was opened in June 2025 and is ran by the Crown Heights Care Collective, a mutual aid network started in 2022. Another World hosts free events surrounding political education and provides basic needs like food and clothing to residents of the area. In just a few months, the group has made inroads in a diverse community altered by gentrification.

Krasg12d Mutation Promotes Pancreatic Tumorigenesis By Suppressing Sirtuin Three Via The Guanine Nucleotide Exchange Factor Rcc1, Taoyi Mai, Mengwen Wang, Ya Qiu, Wenhua Lu, Hongyu Wu, Shuna Chen, Paul J Chiao, Peng Huang

Faculty, Staff and Student Publications

KRASG12D mutation is a prevalent gain-of-function mutation that drives pancreatic cancer tumorigenesis, but the underlying mechanisms that promote KRAS-induced cell proliferation and tumor formation remain elusive. To uncover the molecular pathways that facilitate KRASG12D-driven malignant transformation, we measured the transcriptomic alterations at various time points after induction of KRASG12D expression in human pancreatic normal epithelial cells. KEGG pathway enrichment of the differentially expressed genes (DEGs) showed that the major DEGs were located in pathways that regulate nicotinate/nicotinamide metabolism, TNF signaling, and microRNAs associated with cancer. Among these molecular alterations, the NAD-dependent deacetylase gene SIRT3 was significantly down-regulated by KRASG12D. Conversely, …

Recreating Fiber Recruitment With Fiber Recruitment Using Additive Manufacturing, Natalia D. Mciver

Biomedical Engineering ETDs

Injured ligaments are often repaired with tendon grafts which may over or under constrain the joint; there is a need for an artificial graft option with the mechanical properties of a native ligament. Crimped fibers within ligaments allow for recruitment which means the viscoelastic properties of stress relaxation and creep are not inversely related. A feasibility study using ACLs and large-scale crimp models to study viscoelasticity, led to an in-depth analysis of the scapholunate interosseous ligament. Using the Modified Kelvin spring-dashpot model, for describing viscoelasticity with a variable stiffness property (time dependent fiber recruitment), we defined the relationship between creep …

Methodology For The Pediatric Dose Optimization For Seizures In Emergency Medical Services (Pedidose) Study, Manish I Shah, Kathleen M Adelgais, James M Chamberlain, Henry E Wang, Lindsey A Morgan, James J Riviello, Rana R Said, Joseph E Sullivan, Kimia F Ghaffari, Kathryn M Kothari, Mohsen Saidinejad, Robert A Lowe, Raymond L Fowler, Catherine R Counts, Claudia R Morris, Jonathan R Studnek, Nancy K Glober, Caleb E Ward, Brian M Clemency, Nicholas Patrick, Rachel D Munn, Graham M Brant-Zawadzki, Christian Martin-Gill, Daniel K Nishijima, Kevin Li, Neomi Sepulveda, John M Vanburen

Faculty, Staff and Student Publications

Background: Seizures are one of the most common reasons for emergency medical services (EMS) activation for children, and current EMS practice results in underdosing and delayed delivery of anti-seizure medication. A prehospital evidence-based guideline recommends using intranasal or intramuscular midazolam as first-line treatment for pediatric seizures. Despite attempts to implement these guidelines, one-third of children having a paramedic-witnessed seizure have ongoing seizures on emergency department (ED) arrival; this may be due to inadequate or delayed midazolam dosing. Replacing the error-prone, sequential calculations with age-based midazolam dosing may be simpler, faster, and more effective without compromising safety. The objective of this …

Pen And Punishment: Revenge And Role Reversal In Edith Wharton’S World. A Rewriting Of Gender Roles And The Subversion Of Patriarchy., Shelly Ann Justin

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATION Pen and Punishment: Revenge and Role Reversal in Edith Wharton’s World. A Rewriting of Gender Roles and the Subversion of Patriarchy. by Shelly Ann Justin An unlikely feminist writer sometimes becomes one of the greatest advocates for the feminine movement, and that is exactly what American novelist, Edith Wharton (1862-1937) has done for over 120 years through her essays, short stories, and more specifically, her novels. She is best known for her vivid novels that explore the complexities of American society, especially the upper class which examines the constraints and social expectations of New York’s upper …

Protein-Nucleic Acid Language Model-Assisted Design Of Precise And Compact Adenine Base Editor, Jingxuan Ren, Jiawei Yao, Qiuyu Cao, Yinuo Li, Yang Li, Ziyi Zhang, Xiyu Ge, Shengfang Wang, Yang Zhang, Xiaogang Wang, Xiaohui Zhang

Faculty, Staff and Students Publications

Adenine base editors (ABEs) are powerful tools for gene therapy. However, efficient version of ABEs (e.g. ABE8e) always induce excessive bystander and off-target editing events and are large in size, hindering their potential in clinical disease treatment. Here, we develop a pre-trained Protein-Nucleic Acid Constrained Language Model to design ABE8e with high activity, reduced editing window and decreased size. By further engineering, the smallest ABE8e- PNLM-pcABE- with a 27% size reduction, exhibits high activity, precise 3-nt editing window, and reduced off-target events near background level in HEK293T cells. Compared to ABE8e, PNLM-pcABE has up to 133.5-fold precision improvement in pathogenic …

Design And Evaluation Of The Influence Of Mutual Induction On Microbial Electrolysis Cell Performance And Biogas Production, Ashley L. Blackwell

Civil Engineering ETDs

Microbial electrolysis cells (MECs) present a pathway for energy recovery in wastewater treatment by converting organic substrates into methane or hydrogen. Traditional MEC designs typically rely on physical electrode contacts and expensive materials, which restrict their scalability. This study introduces the first induction-based MEC that uses mutual inductance between an external copper wrap and an internal coil to generate a fluctuating electrical potential, removing the need for expensive electrodes. The induction-stimulated reactor showed faster total organic carbon removal and a higher CH4/CO2 ratio compared to a conventional anaerobic digester, indicating improved carbon-to-methane conversion, although total gas yield remained similar. Microbial …

Book Review: Academic Coaching: Coaching College Students For Success, Corinne Bishop

Journal of Graduate Librarianship

Book review: Howlett, M. A., & Rademacher, K. (2023). Academic coaching: Coaching college students for success. Routledge. 196 pp. ISBN: 9781032272214 (paperback), 9781032265711 (hardcover), 9781003291879 (ebook).

Becoming Steve Bright, Robert L. Tsai

Kentucky Law Journal

No abstract provided.

¿Cómo Se Dice, "Liberty And Justice For All Cannot Exist Without Equal Access For All" En Español?, Turner Denise Reynolds

Kentucky Law Journal

No abstract provided.

2025 Fall Commencement Program: Winona State University, Winona State University

WSU Commencement Programs

This is the Winona State University Fall 2025 commencement program. Commencement was on Friday, December 12, 2025. There were 2 ceremonies at 9:00am and 11:30am.

During the Commencement event, a complete list of graduates was provided online. This program was not published during the Commencement event. This digital copy is maintained in the repository for archival purposes.

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

Validity And Reliability Of The Turkish Version Of The Topical Corticosteroid Phobia (Topicop) Scale, Esra Ağaoğlu, Hi̇lal Kaya Erdoğan, Hi̇lal Çavuş, Selma Meti̇ntaş

Turkish Journal of Medical Sciences

Background/aim: Concerns about the use of topical corticosteroids (TCSs), commonly referred to as corticophobia, are widespread among dermatology patients and often lead to nonadherence to TCS treatment. This study aimed to evaluate the validity and reliability of the Turkish version of the topical corticosteroid phobia (TOPICOP) scale.

Materials and methods: The TOPICOP scale comprises 12 items grouped into 2 dimensions: beliefs (6 items) and worries (6 items). For cultural adaptation, the scale was forward and backward translated. The final Turkish version was administered to 123 patients with chronic dermatoses who rated their perceptions of TCSs using a 4-point Likert scale. …