Digital Commons Network^™

A Systematic Characterization Of Fibroblast Subtypes And Heterogeneity, Xiuli Zhu, Hongen Kang, Zhongming Zhao, Peilin Jia

Faculty, Staff and Student Publications

Fibroblasts are essential components in development, disease, and treatment response, yet their diversity and function remain incompletely understood. Here, we constructed a comprehensive fibroblast landscape by integrating large-scale single-cell and single-nucleus RNA sequencing datasets spanning 60 major human organs and tissues across various developmental stages and biological conditions. We identified 16 fibroblast subtypes and systematically characterized their tissue specificities, transcriptional heterogeneity, and cell states. Further analyses revealed distinct fibroblast subtypes associated with pluripotency and senescence across tissues. Leveraging the well-defined fibroblast atlas, we demonstrated that different fibroblast subtypes were associated with various complex traits such as anthropometric and immune diseases. …

Accepting Vs Understanding, Transgender Aliens And Alienation, Reyna G. Aliah

English

Trans people have been the subject of intense discrimination in recent years, suffering dehumanization from right-wing and conservative groups. This dehumanization (and the fear resulting from it) parallels common attitudes in science fiction about actual aliens. Orson Scott Card’s Hierarchy of Foreignness classifies individuals and species into five categories, depending on their sentience; whether they are from the same city, nation, or planet; and whether communication is possible. This paper examines how transgender people can be classified according to this system on a societal level, with said class depending on the lens used to view them as well as the …

Facilitators Of Routine Cervical Screening Receipt For Women With Intellectual And Developmental Disabilities In Nebraska, Anne Woodruff Jameson

Theses & Dissertations

Women with intellectual and developmental disabilities (I/DD) experience disproportionately low rates of cervical screening relative to women without I/DD, despite its clear role in cancer prevention. This disparity is especially stark in Nebraska, where in 2023, only 56% of women with I/DD had cervical screen receipt, compared to 78.4% of their non-disabled peers.. Previous literature has explored barriers to cervical screening for women with I/DD using the socioecological model (SEM) as a framework. This dissertation used three methodologies: a case study, a scoping review, and survey research, to examine facilitators to cervical screening for women with I/DD using the SEM …

Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari

Theses & Dissertations

Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.

For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …

Probing The Mechanisms Of Reinforcement Learning: Reinforcement Learning, Ventral Striatal Astrocytes, And The Dynamic Coordination Of Information Seeking With Learning, Fatih Sogukpinar

McKelvey School of Engineering Graduate Student Theses & Dissertations

While reinforcement learning has been a vital component in artificial intelligence and machine learning, there exist many open questions about its implementations and how to improve them, in both minds and machines. Among these are i) the contribution of non-neuronal cell types to reinforcement learning, and ii) information-seeking behavior during reinforcement learning. In this thesis, we studied these main topics pertaining to reinforcement learning. In the first chapter, we examined the role of astrocytes in reinforcement learning, and in the second, we investigated human information seeking during reinforcement learning. Neurons in the human and animal brain have been known to …

A Framework For Fostering Flood Ready Neighborhoods, Kirsten Howard, Lucy Perkins, Alyson Eberhardt, Lisa Wise, Abigail Lyon, Lynn Vaccaro, Gracie Ballou, Annie Cox, Kate O'Brien

UNH Cooperative Extension

This resource summarizes lessons learned from the Flood Ready Neighborhoods Program and shares prompts and resources for readers related to community engagement and resilience building.

Optimal Sizing Of Battery Energy Storage Systems For Peak Shaving And Demand Response Using A Degradation-Aware Bayesian Optimization-Mixed-Integer Linear Programming Framework, Jiwei Yao, Blake Billings, Tao Gao, John Hedengren, Kody M. Powell

Faculty Publications

The increasing integration of renewable energy and rising electricity demand highlight the importance of battery energy storage systems for peak shaving and demand response. Unlike prior approaches that overlook operational impacts on degradation, this study proposes a Bayesian Optimization–Mixed Integer Linear Programming framework for optimal battery energy storage system sizing. In this framework, Mixed Integer Linear Programming determines short-term scheduling while a calibrated electrochemical model iteratively evaluates degradation. The central hypothesis is that the framework can efficiently identify optimal sizes that yield realistic and economically robust outcomes. The method is tested across three scenarios: peak shaving, peak shaving with energy-reduction …

Organizational Return On Investment In Nursing: A Systematic Review, Olga Yakusheva, Kathryn Lee, Alissa V. Fial, Marianne E. Weiss

Individual Articles

Background: High-quality nursing care is crucial for healthcare quality and safety, yet there’s limited understanding of the business case for investing in nursing from an organizational perspective. This study seeks to address this evidence gap by identifying and synthesizing data on the organizational return on investment in nursing human capital, considering initial investment costs and the resulting impact on production costs and revenue.

Method: We conducted a systematic review using four databases (PubMed, CINAHL, EconLit, Web of Science) to find nursing human capital studies from January 1990 to June 2024. Studies were eligible for inclusion if they examined nurses …

Adaptive Neuromodulation Dialogues: Navigating Current Challenges And Emerging Innovations In Neuromodulation System Development, Frederik Lampert, Matthew R Baker, Michael A Jensen, Amir H Ayyoubi, Christian Bentler, Jessica L Bowersock, Rosana Esteller, Jeffrey A Herron, Graham W Johnson, Daryl R Kipke, Christopher K Kovach, Vaclav Kremen, Filip Mivalt, Joseph S Neimat, Theoden I Netoff, Enrico Opri, Alexander Rockhill, Joshua M Rosenow, Kristin K Sellers, Nathan P Staff, Chandra Prakash Swamy, Ashwin Viswanathan, Gerwin Schalk, Timothy Denison, Dora Hermes, Nuri F Ince, Peter Brunner, Gregory A Worrell, Kai J Miller

Faculty, Staff and Students Publications

Adaptive neuromodulation systems and implantable brain-computer interfaces have made notable strides in recent years, translating experimental prototypes into clinical applications and garnering substantial attention from the public. This surge in interest is accompanied by increased scrutiny related to the safety, efficacy, and ethical implications of these systems, all of which must be directly addressed as we introduce new neurotechnologies. In response, we have synthesized the insights resulting from discussions between groups of experts in the field and summarized them into five key domains essential to therapeutic device development: (1) analyzing current landscape of neuromodulation devices and translational platforms (2) identifying …

Evaluation And Calibration Of Coupled Low-Cost Particulate Matter Sensors, Tyler Cargill

McKelvey School of Engineering Graduate Student Theses & Dissertations

Low-cost sensors (LCS), if used appropriately, are useful instruments to elucidate human exposure to particles suspended in the air (i.e. particulate matter, PM). Characterizing this exposure is crucial, as exposure to PM2.5 (i.e. particles with aerodynamic diameter ≤ 2.5 μm) negatively affects the respiratory, cardiovascular, and other organ systems and is the leading environmental burden for global mortality. Similarly, exposure to particles with aerodynamic diameters greater than 2.5 μm and less than or equal to 10 μm, here forth termed as PMCoarse, is known to cause health ailments for the upper respiratory system. This dissertation focuses on the MODULAIRTM-PM (MOD-PM), …

Investigating Metabolic Heterogeneity In Engineered Isogenic Microorganisms, Xinyue Mu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Engineered microorganisms play an increasingly important role in the sustainable production of fuels, bioplastics, and other valuable biomaterials. Successful industrial deployment depends on maximizing product titers and ensuring process robustness at large scale. However, one of the major obstacles is non-genetic cell-to-cell heterogeneity arising from stochastic intracellular processes. Such heterogeneity can result in subpopulations that divert substrates toward growth rather than product biosynthesis, ultimately reducing yield and contributing to batch-to-batch inconsistency. To better understand the mechanisms by which cell-to-cell variation emerges, propagates, and impacts bioproduction, this dissertation investigated how intracellular energetic dynamics and stochastic biosynthetic noise contributed to metabolic heterogeneity …

Learning From Images And Text (Clinical) Data: Toward Putting Ai In Radiology Workflows, Pan Xiao

McKelvey School of Engineering Graduate Student Theses & Dissertations

The rapid growth of medical imaging data highlights the need for intelligent systems that can understand both radiological language and image content. This dissertation presents two complementary research directions that advance machine learning in radiology through large-scale natural language understanding and unsupervised image representation learning. The first part develops and benchmarks machine learning models for identifying follow-up recommendations in radiology reports—a task essential for improving patient care and reducing missed follow-ups. Using 49,769 reports across multiple modalities and three institutional datasets, along with external and temporal test sets, thirty-two classification methods were systematically evaluated on both findings and impression sections. …

Transforming Co2 Into Value-Added Products: Liquefied Petroleum Gas And Solid Carbon Materials, Kaiying Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

The escalating climate crisis, driven by anthropogenic carbon dioxide (CO2) emissions, necessitates the development of advanced Carbon Capture and Utilization (CCU) technologies. A critical distinction within CCU lies between transient carbon cycling, which converts CO2 into fuels, and permanent sequestration, which transforms it into durable, solid materials. This dissertation addresses fundamental catalytic challenges across both pathways to develop economically viable and technologically sound solutions for CO2 valorization. This work seeks to answer two primary research questions: (1) How can the catalyst temperature mismatch and stability limitations in the tandem conversion of CO2 to Liquefied Petroleum Gas (LPG) be overcome to …

A Fish & A Bird, Deanna Moorehead

Theses

As a curtain of trees opens and dawn breaks over the glistening waters of Lake Ontario, a fish and a bird spot each other through the surface and fall madly in love. They dance and sing together from their respective atmospheres, yet each time the bird soars past the water's edge and onto the beach, the fish cannot follow. Night after night, by the light of the moon, the fish trains herself to leap out of the water, hoping to breach high enough to join her beau above. Late one afternoon, the fish approaches the shore, where the bird stands …

Single-Nucleus Multiomics Reveals The Disrupted Regulatory Programs In Three Brain Regions Of Sporadic Early-Onset Alzheimer’S Disease, Andi Liu, Citu Citu, Nitesh Enduru, Xian Chen, Chia-Hao Tung, Tirthankar Sinha, Sofia E Sepulveda, Astrid M Manuel, Damian Gorski, Brisa S Fernandes, Meifang Yu, Paul E Schulz, Lukas M Simon, Claudio Soto, Zhongming Zhao

Faculty, Staff and Student Publications

Sporadic early-onset Alzheimer’s disease (sEOAD) represents a substantial but less-studied subtype of Alzheimer’s disease (AD). Here, we generated a single-nucleus multiome atlas derived from the postmortem prefrontal cortex, entorhinal cortex, and hippocampus of nine individuals with or without sEOAD. Comprehensive analyses were conducted to delineate cell type–specific transcriptomic changes and linked candidate cis-regulatory elements (cCREs) across brain regions. We prioritized eight conservative transcription factors in glial cells in multiple brain regions, including RFX4 in astrocytes and IKZF1 in microglia, which are implicated in regulating sEOAD-associated genes. Moreover, we identified the top 25 altered intercellular signaling between glial cells …

Metabolomic Profiling Reveals Brain Lipid Alterations In Pex7-Deficient Models Of Rhizomelic Chondrodysplasia Punctata, Riya Sankhe, Meredith I Williams, Wedad Fallatah, Laura Mackay, Mary Layne Brown, Pranjali Bhagwat, Sarah H Elsea, Nancy Braverman, Michael F Wangler

Duncan NRI Faculty and Staff Publications

Rhizomelic chondrodysplasia punctata type 1 (RCDP1) is a peroxisomal disorder characterized by skeletal shortening, intellectual disability, seizures, cataracts, and reduced lifespans. RCDP1 is caused by biallelic loss-of-function variants in PEX7, which encodes a protein required for importing select enzymes into the peroxisome matrix, including those essential for ether lipid synthesis (e.g., plasmalogens) and the branched-chain fatty acid catabolism. Plasmalogen deficiency is a hallmark of RCDP1 and other peroxisomal disorders, including RCDP types 2-5 (RCDP2-5) and Zellweger spectrum disorders (ZSD). Here, we performed comprehensive metabolomic profiling of clinical samples from RCDP patients and Pex7-deficient mouse models. We identified profound …

P-15 Peptide Enhanced Bone Graft Improves Time To Fusion In Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study, James S. Harrop, Michael P. Steinmetz, John E. O'Toole, Christopher D Chaput, Rick C. Sasso, K. Brandon Strenge, Greg Maislin, Jeffrey P. Mullin, Thomas B. Freeman, Anthony Guanciale, Howard Lantner, Michael E. Janssen, David G. Schwartz, John M. Small, Wellington K. Hsu, Paul M. Arnold

Department of Neurosurgery Faculty Papers

STUDY DESIGN: Prospective, multicenter, single-blind, randomized, and controlled pivotal study.

OBJECTIVE: Compare time-to-fusion in patients treated with P-15L (PearlMatrix TM P-15 peptide enhanced bone graft) versus local autograft over 24 months and evaluate changes in pain and quality of life at 24 months relative to baseline.

SUMMARY OF BACKGROUND DATA: P-15L, an FDA-designated breakthrough device, is a composite bone graft with P-15, a 15-amino acid polypeptide that promotes cellular adhesion, proliferation, and differentiation to support bone formation.

METHODS: Patients (22-80 y) with degenerative disc disease were randomized to the investigational (P-15L) or control (local autograft) group during single-level transforaminal lumbar …

The Impact Of Patient-Generated Health Data From Mobile Health Technologies On Health Care Management And Clinical Decision-Making: Narrative Scoping Review, Ava Keeling, John Downey, Matthew Halkes, Yinghui Wei

School of Nursing and Midwifery

Background: Long-term health conditions and multimorbidity are increasing globally, placing an unsustainable pressure on health care systems. Mobile health (mHealth) technologies enable the collection of patient-generated health data outside clinical settings, offering the potential to support personalized care and inform clinical decision-making. However, the ways in which mHealth patient data are being used in clinical practice remain unclear. Objective: This study aimed to map and synthesize the existing literature on how patient-generated mHealth data are reportedly being used and influencing clinical decision-making for adults with long-term conditions in an outpatient care setting. Methods: A narrative scoping review was conducted on …

Daily Intake Of A Lycopene-Rich Juice Is Associated With Reductions In Inflammatory Markers But Not Increases In Skin Carotenoids In A Pilot Study Among Participants With Obesity, Stephanie B Jilcott Pitts, Qiang Wu, Melissa N Laska, Elizabeth Gates, Megumi H Seese, Katelyn E Senkus, Santiago Carrero Longlax, Alexandra Portillo-Varela, Andrew R Dinardo, Nancy E Moran

Faculty, Staff and Students Publications

Background

Obesity is associated with systemic inflammation, increasing chronic disease risk. Carotenoids possess anti-inflammatory properties, yet the short-term impact of carotenoid-rich juice intake on inflammation in individuals with obesity remains unclear. Therefore, the purpose of this paper was to examine: (1) participant adherence to a 3-week lycopene-rich juice intervention; (2) variance and effect sizes of responses to the dietary intervention; (3) changes in skin and plasma carotenoids, and inflammatory markers among adults with obesity.

Methods

Twenty-five participants with body mass index (BMI) > 30 kg/m2 were recruited and completed the study. Participants drank 4 ounces (118.3 mL) of study-provided tomato juice, …

Socrates And Early Buddhist Medical Ethics: Foundations Of Moral Reasoning In The Care Of Body And Mind, Chandima Gangodawila

Budhi: A Journal of Ideas and Culture

While Buddhist traditions articulate a parallel moral vision in the early discourses of the Pāli Canon, Western traditions usually locate the roots of ethical reasoning in Socratic inquiry. Especially in their approaches to bodily care, spiritual well - being, and moral responsibility, this article contends that both Socratic and Early Buddhist ideas converge on fundamental principles in medical ethics. Through a comparative textual and philosophical study, the paper examines how Socratic dialectics and the Buddha's diagnostic approach to dissatisfa ction/ suffering (dukkha) both produce frameworks for ethical healthcare anchored in the development of virtue, wisdom, and care for the integrity …

Central Bank Crisis Interventions: A Review Of The Recent Literature On Potential Costs, Patrick Aldridge, David A. Cimon, Rishi Vala

Journal of Financial Crises

Central banks may engage in large-scale lending and asset purchases to stabilize financial markets and implement monetary policy during crises. The ability of these actions to restore financial market functioning is well documented; however, they come with costs. We provide a literature review of the costs associated with these post-Global Financial Crisis central bank actions, without commenting on the net benefits they provide. We find support for the premise that crisis actions may negatively impact market liquidity, distort asset prices, increase rent-seeking and inefficient uses of the liquidity provided by the central bank, create international spillovers, and create distortions in …

Extending The Emotional And Multiple Intelligence Theories: Integrating Cultural And Spiritual Intelligence Constructs To Fill Research Gaps, Kimberly J. Mcdonald

The Scholarship Without Borders Journal

This proposed mixed-methods convergent research study aims to explore extending the Emotional Intelligence (EI) and Multiple Intelligences Theories by integrating Spiritual Intelligence (SI) and Cultural Intelligence (CQ) constructs. The goal is to explore the interconnectedness of these intelligences to bridge existing research gaps concerning leadership, EI, SI, and CQ. By employing both quantitative and qualitative data collection methods from organizational leaders, this study seeks to develop a more comprehensive and holistic understanding of leadership efficacy across various organizational contexts. The anticipated outcomes aim to contribute to the body of knowledge and potentially impact leadership development in business, education, and other …

Equity And Effectiveness In Advanced Mathematics Education: A Literature Review Of Ap Calculus, Cambridge Aice, And Ib Curricula, Jinhee Lee

The Scholarship Without Borders Journal

This literature review investigates equity and effectiveness of three globally recognized advanced high school mathematics programs: AP Calculus, Cambridge International Advanced International Certification of Education (AICE) Advanced Level (A-Level) Mathematics, and International Baccalaureate (IB) Mathematics High Level. Access to advanced mathematics is unequally distributed, impacting underprivileged students (Bressoud, 2021). This review examines curriculum content, teaching methods, and assessment strategies in alignment with college admissions, depth of conceptual understanding, inclusion of diverse approaches, and assessment accessibility. Findings will contribute to informed curriculum choices for students and inform equitable practices for educators.

Our Land: Rodger Mcafee And His Life-Long Quest For Community In America, Morgan E. Bowen

Communal Societies

No abstract provided.

Review Of The Utopian Prince: Robert Owen And The Search For The Millennium, Jayne Kamau

Communal Societies

No abstract provided.

The Communal System Of The Amana Colonies: Impact Of Hired Labor, 1884-1932, Angela Tjaden

Communal Societies

No abstract provided.

Zoar In The Civil War: Choosing Between Pacifism And Participation, Philip E. Webber

Communal Societies

No abstract provided.

The Communal Wanderings Of August Jacobi, Peter Hoehnle

Communal Societies

No abstract provided.

From Developmental Communalism To Transformative Utopianism: An Imagined Conversation With Donald Pitzer, Joshua Lockyer

Communal Societies

No abstract provided.

Burden Of Light: The Emissary Of Divine Light Myth System As A Unifying Community Force, Sandy Brown Jensen

Communal Societies

No abstract provided.