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Articles 27331 - 27360 of 1440143
Full-Text Articles in Entire DC Network
Reimagining A Nexus Between Seaport And National Development: Sociotechnical Imaginaries Of Ghana’S Port Of Tema, Jonas Aryee, Casper Andersen, Annette Hansen
Reimagining A Nexus Between Seaport And National Development: Sociotechnical Imaginaries Of Ghana’S Port Of Tema, Jonas Aryee, Casper Andersen, Annette Hansen
Plymouth Business School
This article explores the evolving sociotechnical imaginaries (STIs) shaping Ghana’s Port of Tema, revealing how national development goals and global trade imperatives intersect in African port governance. Through analysis of policy documents, media discourse, and interviews, it identifies four overlapping phases in the evolution of these imaginaries: the industrial gateway era, neoliberal globalization, the rise of a transshipment hub, and the most recent phase of indigenous contestation and institutional resilience. Rather than replacing earlier visions, newer imaginaries build upon and hybridize older ones, creating both synergies and tensions. The study demonstrates that STIs at Tema have evolved through processes of …
Lived Oral Health Experiences Of Syrian Refugees In The United States, Taniya Michael Henry-Sangar
Lived Oral Health Experiences Of Syrian Refugees In The United States, Taniya Michael Henry-Sangar
Walden Dissertations and Doctoral Studies
The oral health status of Syrian refugees has been impacted by war and displacement since the 2011 civil war. To date, limited in-depth knowledge is available on oral health experiences of resettled Syrian refugees in the United States. The purpose of this qualitative study was to explore lived oral health experiences of resettled Syrian refugees before, during, and after the 2011 Syrian civil war. The health belief model (HBM) and theory of planned behavior (TPB) were theoretical frameworks for this phenomenological inquiry. The study was guided by semi-structured phone interviews with a purposeful sample of 11 Syrian refugees over the …
A Phase-Ii Randomized Controlled Pilot And Feasibility Study Of Nicotinamide Riboside Supplementation In Older Adults With Amnestic Mild Cognitive Impairment, Christopher R. Martens, Kevin P. Decker, Theodore M. Deconne, Faria Sanjana, Fiona Horvat, Nicholas A. Rizzi, Catherine Awad, Elizabeth Habash, Joshua C. Hobson, Michael L. Armstrong, Nichole Reisdorph, Ryan T. Pohlig, Alyssa M. Lanzi, Curtis L. Johnson, Matthew L. Cohen, James M. Ellison
A Phase-Ii Randomized Controlled Pilot And Feasibility Study Of Nicotinamide Riboside Supplementation In Older Adults With Amnestic Mild Cognitive Impairment, Christopher R. Martens, Kevin P. Decker, Theodore M. Deconne, Faria Sanjana, Fiona Horvat, Nicholas A. Rizzi, Catherine Awad, Elizabeth Habash, Joshua C. Hobson, Michael L. Armstrong, Nichole Reisdorph, Ryan T. Pohlig, Alyssa M. Lanzi, Curtis L. Johnson, Matthew L. Cohen, James M. Ellison
Department of Psychiatry and Human Behavior Faculty Papers
Abstract
Background
The decline of nicotinamide adenine dinucleotide (NAD+) with aging may elevate risk of Alzheimer’s disease and related neurocognitive disorders (ADRD) by impairing cellular energy metabolism and reducing cerebral blood flow.
Method
We conducted a 12-week double-blind, randomized, placebo-controlled pilot study to evaluate the safety, tolerability, and preliminary efficacy of the NAD+ precursor, nicotinamide riboside (NR; 500 mg b.i.d.), for enhancing cognitive function and cerebral perfusion in older adults with mild cognitive impairment (MCI).
Result
52 participants (33 females, 19 males) were randomized and 42 completed the trial (NR = 22, placebo = 20). Adherence was similar between groups …
The Nonlinguistic Factors That Predict Spanish Oral Proficiency, Merrie Kay Ames
The Nonlinguistic Factors That Predict Spanish Oral Proficiency, Merrie Kay Ames
Theses and Dissertations
This study investigates the predictive power of self-assessment and nonlinguistic factors in determining Spanish oral proficiency among university learners. Drawing on data from 2,475 undergraduate students enrolled in a third-year Spanish course at Brigham Young University, the research examines how self-assessed speaking ability and experiential background variables--including age of acquisition, mission service, dual immersion, and study abroad--influence Oral Proficiency Interview - Computer (OPIc) scores. A one-way ANOVA revealed a statistically significant but modest relationship between students' calibration (self-assessment minus actual ability) and their OPIc ratings, suggesting that learners can generally approximate their speaking proficiency within two sublevels. A multiple regression …
Integration Of Afghan Refugee Professionals Into American Society, Khatera Bahrami
Integration Of Afghan Refugee Professionals Into American Society, Khatera Bahrami
Walden Dissertations and Doctoral Studies
This study explored the social and psychological challenges Afghan refugee professionals experienced when they entered the U.S. workforce after being forcibly displaced. Trauma, job loss, and cultural adjustment significantly impacted their mental health and reintegration. The study examined how social and psychological obstacles impacted their cultural adjustment, well-being, and capacity to deal with credentialing and professional demands. This research employed a qualitative phenomenological design, grounded in Conservation of Resources (COR) Theory and the Stress Appraisal Model, using 60-minute audio-only, semi-structured interviews with 10 Afghan refugee professionals. Using Reflexive Thematic Analysis (RTA), according to the findings, participants faced challenges relating to …
Investigating Trust Between Hispanic Immigrants And Law Enforcement, Nina Marie Morales-Perez
Investigating Trust Between Hispanic Immigrants And Law Enforcement, Nina Marie Morales-Perez
Walden Dissertations and Doctoral Studies
In this qualitative study, the evolving perceptions of law enforcement among child immigrants from Central and South America following their immigration to the United States were investigated. Anchored in social learning theory, the aim was to discern whether interactions with law enforcement in their home countries and the United States influence these perceptions. A phenomenological approach was used to conduct in-depth interviews with six Latino individuals who immigrated between the ages of 7 and 17 and are at least 18 years old at the time of their interview. Participants were recruited through purposeful sampling, and interview questions were used to …
Beyond The Human–Animal Transformation In Hasan Aourid’S SīRat ḤImāR And Rawi Hage’S Cockroach, Noha Hanafy
Beyond The Human–Animal Transformation In Hasan Aourid’S SīRat ḤImāR And Rawi Hage’S Cockroach, Noha Hanafy
English Language and Literature
The paper examines the human-animal transformation as a marker of identity explo-
ration in Moroccan writer Hassan Aourid’s Sīrat Ḥimār (2014 سيرة حمار) and Lebanese
Canadian writer Rawi Hage’s Cockroach (2008). The two texts employ the concept of
the human-animal transformation to highlight the complexity of the marginalized
existence in the world. Both texts present nuanced versions of the human-animal
transformation which renders the experience both emancipatory and destabilizing at
the same time. Using the theoretical framework of Deleuze and Guattari’s work on
becoming-animal and the deterritorialization of existence along with Derrida’s discus-
sion of the anthropocentric limit, the paper …
Design Of An Fsae Muffler, Suzy Schwabl
Design Of An Fsae Muffler, Suzy Schwabl
Mechanical Engineering and Materials Science Independent Study
To compete in the dynamic events at the the Formula SAE IC competition, each vehicle must undergo a rigorous technical inspection. One element of the inspection is the Noise Test, which states that each car must be quieter than 103 dBc when idling and less than 110 dBc at the engine redline. Over the past few years, WashU Racing has used off-the-shelf mufflers with a guess and check system to find muffler combinations that satisfy the noise requirement. The results of that method have yielded either heavy and performance damaging muffler configurations or mufflers that have failed to meet the …
Debunking The Myth: A Dive Into The Role Of Relational Capital In Sustainable Food Production Systems, Ismail Badraoui, Tarik Saikouk, Nejib Fattam, Ahmed Hamdi, Vikas Kumar
Debunking The Myth: A Dive Into The Role Of Relational Capital In Sustainable Food Production Systems, Ismail Badraoui, Tarik Saikouk, Nejib Fattam, Ahmed Hamdi, Vikas Kumar
All Works
The shift towards sustainable food production is essential to address the urgent dual challenges of climate change and population growth, with agricultural cooperatives playing a vital role in this transformation. However, many cooperatives struggle to deliver the expected value to their members. By considering cooperatives as member-centred production systems, this research investigates relational capital's role in determining cooperative success. This study uses a sequential mixed-methods research approach. First, we use empirical survey data from 320 farmers to test a moderated mediation model that links relational capital to collaboration activities and outcomes. Then, we use qualitative responses from 50 farmers to …
Electrochemical Behavior Of Dental Alloys After Surface Modification By Sputtering Coating Technique, Noor Muneerabdulsahib, Nidhal Sahib Mansoor, Muna Noori Ismail
Electrochemical Behavior Of Dental Alloys After Surface Modification By Sputtering Coating Technique, Noor Muneerabdulsahib, Nidhal Sahib Mansoor, Muna Noori Ismail
Hilla University College Journal For Medical Science
For metallic materials, the corrosion behavior is the most important property to be considered due to the biocompatibility and cytotoxicity of the products of the corrosion process in vivo. Numerous coating processes have been developed to improve corrosion resistance, enhance the metal’s surface qualities, and increase its service life. The purpose of this review was to gather data on the corrosion of alloys in dentistry and plasma sputtering coating techniques to improve the surface characteristics of substrates. Several databases, including google scholar, pubmed, science direct, and web of science were searched electronically, and a manual search of the scientific literature …
Sox11 Modulates Bcr Signaling Through The Pax5/Cd19 Axis For Therapeutic Targeting In Btk-Resistant Mantle Cell Lymphoma, Rudra Prasad Dutta, Heng-Huan Lee, Violetta V Leshchenko, Ravi Prakash Shukla, Fangfang Yan, Yang Liu, H Ümit Kaniskan, Xing Qiu, Jian Jin, Lapo Alinari, Michael Wang, Samir Parekh
Sox11 Modulates Bcr Signaling Through The Pax5/Cd19 Axis For Therapeutic Targeting In Btk-Resistant Mantle Cell Lymphoma, Rudra Prasad Dutta, Heng-Huan Lee, Violetta V Leshchenko, Ravi Prakash Shukla, Fangfang Yan, Yang Liu, H Ümit Kaniskan, Xing Qiu, Jian Jin, Lapo Alinari, Michael Wang, Samir Parekh
Faculty, Staff and Student Publications
Mantle cell lymphoma (MCL) is an incurable subtype of B-cell non-Hodgkin lymphoma. Despite multiple approved Bruton tyrosine kinase inhibitors (BTKis), resistance to BTKi continues to pose a major clinical challenge. The transcription factor sex determining region Y-box 11 (SOX11) is expressed in most patients with MCL and is associated with poor outcomes. We have previously demonstrated SOX11-dependent B-cell receptor (BCR) signaling in transgenic models of MCL. Here, we report that SOX11 drives BCR signaling via the transcriptional activation of the PAX5/CD19 axis. The translational potential of these results is significant as single-cell RNA sequencing data show that SOX11 is overexpressed …
Coordinated Changes In Stromal And Hematopoietic Cells That Define The Perinatal To Juvenile Transition In The Mouse Thymus, Anusha Vasudev, Colin R Moore, Aparna Calindi, Seung Woo Kang, Bryan R Helm, Jayashree Srinivasan, Siddhartha Shah, Erin Baker, Ruiting Zong, Nandini Singarapu, Scott Casey, Andrew N Macintyre, Ken S Lau, Laura P Hale, Qi Liu, Nancy R Manley, Lauren I R Ehrlich, Ellen R Richie
Coordinated Changes In Stromal And Hematopoietic Cells That Define The Perinatal To Juvenile Transition In The Mouse Thymus, Anusha Vasudev, Colin R Moore, Aparna Calindi, Seung Woo Kang, Bryan R Helm, Jayashree Srinivasan, Siddhartha Shah, Erin Baker, Ruiting Zong, Nandini Singarapu, Scott Casey, Andrew N Macintyre, Ken S Lau, Laura P Hale, Qi Liu, Nancy R Manley, Lauren I R Ehrlich, Ellen R Richie
Faculty, Staff and Student Publications
Perinatal T cells have distinctive phenotypes and functions that may be due in part to age-associated features of stromal cells in the perinatal thymus. We identify age-associated changes in mouse thymic epithelial cells, mesenchyme, endothelium, and hematopoietic antigen-presenting cells from birth to one month of age using single-cell transcriptional profiling, flow cytometry, and imaging. Coordinated cellular and molecular changes occur at 7-14 days of age, designated "transitional ages," as thymus growth switches to homeostasis. E2F target gene expression declines, and the expression of type I interferon response genes increases across diverse cell types at transitional ages. Alterations in thymic stromal …
Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti
Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti
Makara Journal of Science
Antimalarial drug resistance has encouraged various innovations to develop novel drug compounds that are effective, feasible, and safe, adhering to health standards. One way to do that is by observing and predicting the biological activity of drug compounds using quantitative structure–activity relationship (QSAR) analysis. In this study, QSAR analysis was conducted on the 4-N-(methyl)-4-aminoquinoline derivatives, which effectively inhibit the growth of Plasmodium falciparum as a source of malaria. The research stages involved molecular structure modeling, molecular geometry optimization using the AM1 semi-empirical method, and QSAR descriptor calculations, including electronic (atomic charges (q), HOMO and LUMO energies, polarizability (α), …
Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia
Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia
Makara Journal of Science
Microplastics are a serious global problem that arises worldwide because of their widespread use. Exposure to microplastics can negatively affect human and environmental health. In this study, we used molecular docking methods with MOE software (version 2014.0901) to investigate the interaction between the laccase enzyme and several microplastic compounds as a preliminary study of microplastic degradation using enzymes. The Quantitative Structure Analysis Relationship (QSAR) analysis revealed that all microplastic ligands had higher Pa values than Pi, indicating that the laccase enzyme may be biologically active. The findings of the present study show that polyamide (PA) has the lowest binding energy …
Enzyme-Free Colorimetric Sensing Of Glucose Using Silver Nanoparticles With A Green Stabilizing Agent From Capsicum Chinense Jacq Extract, Boyfannie Ivan Putra, Hermin Sulistyarti, Muhammad Mashuri Utama, Aura Ananda Haryanto, Rurini Retnowati, Mohamad Rafi, Akhmad Sabarudin
Enzyme-Free Colorimetric Sensing Of Glucose Using Silver Nanoparticles With A Green Stabilizing Agent From Capsicum Chinense Jacq Extract, Boyfannie Ivan Putra, Hermin Sulistyarti, Muhammad Mashuri Utama, Aura Ananda Haryanto, Rurini Retnowati, Mohamad Rafi, Akhmad Sabarudin
Makara Journal of Science
Diabetes mellitus (DM) is a significant global health issue characterized by abnormal glucose levels in the human body. DM diagnostics are often based on invasive sampling from blood, which poses a potential risk of infection and tissue damage. Therefore, a non-enzymatic and non-invasive method for glucose monitoring is demanded as a simple alternative to glucose detection in urine samples. In this work, enzyme-free glucose determination is based on the formation of silver nanoparticles stabilized by Capsicum chinense Jacq extract (CCJ-AgNPs). Under alkaline conditions, glucose functions as a reducing agent for silver ions, and the extract acts as a stabilizer to …
Enhanced Oviposition Preferences And Larval Performance Of Hermetia Illucens L. In Fruit Wastes Fermented By Effective Microorganisms, Resti Rahayu, Robby Jannatan, Muhamad Ronaldo, Risa Ukhti Muslima
Enhanced Oviposition Preferences And Larval Performance Of Hermetia Illucens L. In Fruit Wastes Fermented By Effective Microorganisms, Resti Rahayu, Robby Jannatan, Muhamad Ronaldo, Risa Ukhti Muslima
Makara Journal of Science
Organic waste comprises a considerable portion of global waste, requiring effective management. The ability of the black soldier fly (Hermetia illucens, BSF) to convert organic waste into biomass has been well reported. However, bioconversion can be hindered by fiber-rich substrates, a challenge that can be addressed through substrate pretreatment. This study examined the oviposition preferences and larval performance of BSFs in several fruit wastes fermented by effective microorganisms (EMs), which were compared to non-fermented substrates. The oviposition attractants utilized pineapple peel and overripe soursop, with larval performance evaluated among different treatments, i.e., non-fermented pineapple peel (NFP), fermented pineapple …
Some New Ecological Aspects Of The Lesser Sunda Endemic Drepanosticta Berlandi (Odonata: Zygoptera: Platystictidae), Muhammad Zulhariadi, Muhammad Setyo Nugroho, Nurul Hidayani
Some New Ecological Aspects Of The Lesser Sunda Endemic Drepanosticta Berlandi (Odonata: Zygoptera: Platystictidae), Muhammad Zulhariadi, Muhammad Setyo Nugroho, Nurul Hidayani
Makara Journal of Science
Drepanosticta berlandi is an endemic damselfly in the Lesser Sunda region of Indonesia, which was first recorded on Lombok Island in the 19th century. Albeit recognized for a century, information on its ecology is still lacking; hence, this study aims to reveal its distribution and habitat preferences. The research was conducted at the Tibu Ijo Waterfall tourist area in West Lombok Regency using line transects combined with field survey in the Kekait River and on footpaths on both sides of the river. Vegetation density, topography, and land survey temperature (LST) were measured at the sampling area using ArcGIS 10.4.1 software. …
Perspectives On The Future Of The Profession Of Microbiology, Todd L Kelson, Heidi B Kaplan, Michelle Dziejman, Shilpa Gadwal, Irene Hulede, Jennifer Bennett, Roger Greenwell, Shelley Payne, Kyle Maclea, Eric Miller, Diana L Vullo, Rebecca Sparks-Thissen, Astral Bertolio, Jorge Cervantes
Perspectives On The Future Of The Profession Of Microbiology, Todd L Kelson, Heidi B Kaplan, Michelle Dziejman, Shilpa Gadwal, Irene Hulede, Jennifer Bennett, Roger Greenwell, Shelley Payne, Kyle Maclea, Eric Miller, Diana L Vullo, Rebecca Sparks-Thissen, Astral Bertolio, Jorge Cervantes
Faculty, Staff and Student Publications
The Profession of Microbiology (POM) embodies the bulk of the American Society for Microbiology (ASM) members and represents the career preparation arm of the ASM for academia, industry, and clinical lab professions. The ASM Council on Microbial Sciences hosted a virtual retreat in 2025 to identify the future of the POM. The retreat presentations centered on workforce development, professional development, innovations in technology, and interdisciplinary collaborations. Various aspects were identified, such as the need to prepare for careers in industry, as an important goal of future training. It was also clear that scientists, in all walks of life, need professional …
Intraosseous Lipoma Of The Calcaneus: A Systematic Review Of Reported Cases, Imaging Characteristics, And Treatment Outcomes, Adam W. Youssef, Paul M. Doney, Cameron Ballard, Dryden Dalbey, Jayden Harrington
Intraosseous Lipoma Of The Calcaneus: A Systematic Review Of Reported Cases, Imaging Characteristics, And Treatment Outcomes, Adam W. Youssef, Paul M. Doney, Cameron Ballard, Dryden Dalbey, Jayden Harrington
Student Publications
Intraosseous lipoma (IOL) of the calcaneus is a rare benign tumor composed of mature adipose tissue that may undergo fat necrosis and calcification. Because its imaging features can overlap with other radiolucent bone lesions, calcaneal IOL is sometimes misclassified and may prompt biopsy or surgical intervention for definitive diagnosis. To better characterize this entity, we conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and performed a comprehensive PubMed search using the terms “intraosseous lipoma”, “calcaneus”, and “heel bone”. Eligible studies included case reports and series published between January 1976 and May 2024 …
Synergistic Effects Of Gfap With Tnfr1 And Tnfr2 On Conversion To Ad Dementia And Overall Survival Across The Alzheimer’S Disease Spectrum, Laura Alejandra Ramirez Tirado, Ann D. Cohen, C. Elizabeth Shaaban, Cristy Matan, Brian J. Lopresti, Milos D. Ikonomovic, Thomas K. Karikari, Victor L. Villemagne, Oscar L. Lopez
Synergistic Effects Of Gfap With Tnfr1 And Tnfr2 On Conversion To Ad Dementia And Overall Survival Across The Alzheimer’S Disease Spectrum, Laura Alejandra Ramirez Tirado, Ann D. Cohen, C. Elizabeth Shaaban, Cristy Matan, Brian J. Lopresti, Milos D. Ikonomovic, Thomas K. Karikari, Victor L. Villemagne, Oscar L. Lopez
Department of Neurology Faculty Papers
Background: We recently reported synergistic effects of TNFR1 and TNFR2 with
astrogliosis resulting in greater vascular burden and neurodegeneration, particularly in
Aβ+ participants. Here, we aimed to assess the interactions of peripheral inflammation
and astrogliosis on incidence of AD dementia and mortality. We hypothesized
synergistic effects with astrogliosis resulting in increased incidence of dementia, and
mortality, particularly in Aβ+ participants.
Methods: Participants of the Gingko evaluation of memory (GEM) study underwent
PiB-PET scans between 2009-2018. GFAP and peripheral inflammatory markers were
measured in 2009 by immunoassay. We evaluated the relationship of peripheral
markers of inflammation (TNFR1,TNFR2) and astrogliosis (GFAPdementia incidence …
The Role Of Reproductive Aging And Surgeries For Alzheimer’S Disease And Related Dementias (Adrd) Diagnoses In The Cardiovascular Health Study, Alexis Reeves, Oscar L. Lopez, Michelle D. Shardell, Hoda S. Abdel Magid, C. Elizabeth Shaaban, Michelle C. Odden
The Role Of Reproductive Aging And Surgeries For Alzheimer’S Disease And Related Dementias (Adrd) Diagnoses In The Cardiovascular Health Study, Alexis Reeves, Oscar L. Lopez, Michelle D. Shardell, Hoda S. Abdel Magid, C. Elizabeth Shaaban, Michelle C. Odden
Department of Neurology Faculty Papers
Abstract
Background
Most US individuals with ADRD are women. Menopause typically occurs in midlife, accompanied by declines in potentially neuroprotective and cardioprotective hormones. Earlier menopause leads to earlier exposure to decreased sex hormones, potentially increasing ADRD risk. Surgical menopause via reproductive surgeries may cause a sudden loss of hormones and may represent be a modifiable risk factor for ADRD. We aimed to determine if menopausal type and age are associated with physician adjudicated-ADRD diagnoses.
Methods
Data were from 3371 women prospectively followed from age 65+ years. Participants self-reported age of menopause and/or surgeries, hormone-therapy, education, and race (Black/White). For this …
Micu2 Controls Mitochondrial Calcium Signaling And Migration In Neurons During Development, Elena Berezhnaya, Benjamín Cartes-Saavedra, Raghavendra Singh, Macarena Rodríguez-Prados, Orly Reiner, Fowzan S Alkuraya, György Hajnóczky
Micu2 Controls Mitochondrial Calcium Signaling And Migration In Neurons During Development, Elena Berezhnaya, Benjamín Cartes-Saavedra, Raghavendra Singh, Macarena Rodríguez-Prados, Orly Reiner, Fowzan S Alkuraya, György Hajnóczky
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Neurological disorders are linked to mitochondrial dysfunction and calcium overload. Mitochondrial calcium uptake is mediated by the mitochondrial calcium uniporter (mtCU), regulated by MICU1, which can be either homodimerized or heterodimerized with MICU2 or MICU3. Though MICU2 is scarce in the adult brain, MICU2 loss in patients leads to a neurodevelopmental disorder. We hypothesized that MICU2 is required for developmental calcium signaling and neuronal migration. MICU2 is present in the developing mouse brain but disappears by maturation, contrasting with other mtCU subunits that increase. MICU2 loss in mice does not affect cytoplasmic calcium but augments the mitochondrial matrix calcium rise …
A Tissue Renewal-Based Mechanism Drives Colon Tumorigenesis, Ryan M. Boman, Gilberto Schleiniger, Christopher Raymond, Juan P. Palazzo, Anne Shehab, Bruce M. Boman
A Tissue Renewal-Based Mechanism Drives Colon Tumorigenesis, Ryan M. Boman, Gilberto Schleiniger, Christopher Raymond, Juan P. Palazzo, Anne Shehab, Bruce M. Boman
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Our Goal is to identify how colorectal cancer (CRC) arises in the single-layered cell epithelium (simple columnar epithelium) that lines the luminal surface of the large intestine. Background: We recently reported that the dynamic organization of cells in colonic epithelium is encoded by five biological rules and conjectured that colon tumorigenesis involves an autocatalytic tissue renewal reaction. Introduction Our objective was to define how altered crypt turnover explains tissue disorganization that leads to adenoma morphogenesis and CRC. Hypothesis: Changes in rate of tissue renewal-based cell polymerization leads to epithelial expansion and tissue disorganization during adenoma histogenesis. Methods: Accordingly, we created …
Pepquerymhc: Rapid And Comprehensive Tumor Antigen Prioritization From Immunopeptidomics Data, Seunghyuk Choi, Bing Zhang
Pepquerymhc: Rapid And Comprehensive Tumor Antigen Prioritization From Immunopeptidomics Data, Seunghyuk Choi, Bing Zhang
Faculty, Staff and Students Publications
Determining tumor-specificity of MHC-bound peptides is crucial for cancer immunotherapy development, yet current methods struggle with class II peptides and non-reference sequences. We introduce PepQueryMHC, an ultra-fast tool that integrates MHC-bound peptide sequences with translated RNA-seq reads for efficient tumor antigen prioritization. We demonstrate its versatility in prioritizing class I and II tumor antigens, mapping the cellular origins of presented peptides, and resolving uncertainties surrounding the prevalence of proteasome-spliced peptides.
Eif3d And Eif3e Mediate Selective Translational Control Of Hypoxia That Can Be Inhibited By Small Molecules, Stephen C Purdy, Kate Matlin, Christopher Alderman, Amber Baldwin, Natasha Shrivastava, Goksu Sarioglu, Somnath Dutta, Kristofor J Webb, Arthur Wolin, Dillon P Boulton, Annika Gustafson, Jyoti Kapali, John D Landua, Michael T Lewis, M Cecilia Caino, James C Costello, William Old, Xiang Wang, Rui Zhao, Heide L Ford, Neelanjan Mukherjee
Eif3d And Eif3e Mediate Selective Translational Control Of Hypoxia That Can Be Inhibited By Small Molecules, Stephen C Purdy, Kate Matlin, Christopher Alderman, Amber Baldwin, Natasha Shrivastava, Goksu Sarioglu, Somnath Dutta, Kristofor J Webb, Arthur Wolin, Dillon P Boulton, Annika Gustafson, Jyoti Kapali, John D Landua, Michael T Lewis, M Cecilia Caino, James C Costello, William Old, Xiang Wang, Rui Zhao, Heide L Ford, Neelanjan Mukherjee
Faculty, Staff and Students Publications
Exposure to hypoxia is linked to increased cellular plasticity and enhanced metastasis, effects that are primarily attributed to the transcriptional activation of large gene programs downstream of hypoxia-inducible factors (HIFs). However, translational effects in hypoxia, which likely precede transcriptional effects, have remained largely unexplored. Using ribosome profiling, we uncovered a selective translational response in acute hypoxia that is eukaryotic initiation factor (eIF)3d/eIF3e dependent and controls downstream hypoxic responses, including HIF1α accumulation and cellular invasion. We further demonstrated that eIF3e copy number and eIF3e and eIF3d expression signatures are associated with worsened outcomes for patients with breast cancer. Finally, we identified …
Liberal Or Restrictive Postoperative Transfusion In Patients At High Cardiac Risk: The Top Randomized Clinical Trial, Panos Kougias, Sherene E Sharath, Min Zhan, Jeffrey L Carson, L Erin Norman, Zhibao Mi, Rupsi Pal, Hasan Dosluoglu, J Gregory Modrall, George A Sarosi, Peter Nelson, Shipra Arya, Alexandra Scrymgeour, Jade Ollison, Lawrence A Calais, Vijay Nambi, L Parker Gregg, Shuaib M Abdullah, Shirling Tsai, Natasha Becker, Justin C Choi, Louisa Chiu, Salvatore Scali, Neal R Barshes, Samir Awad, Mohammed Moursi, Matthew C Koopmann, Mitchell Sally, Daniel Ihnat, Archana Ramaswamy, Warren Gasper, Edith Tzeng, Mark A Wilson, Gale Tang, Grant Huang, Kousick Biswas
Liberal Or Restrictive Postoperative Transfusion In Patients At High Cardiac Risk: The Top Randomized Clinical Trial, Panos Kougias, Sherene E Sharath, Min Zhan, Jeffrey L Carson, L Erin Norman, Zhibao Mi, Rupsi Pal, Hasan Dosluoglu, J Gregory Modrall, George A Sarosi, Peter Nelson, Shipra Arya, Alexandra Scrymgeour, Jade Ollison, Lawrence A Calais, Vijay Nambi, L Parker Gregg, Shuaib M Abdullah, Shirling Tsai, Natasha Becker, Justin C Choi, Louisa Chiu, Salvatore Scali, Neal R Barshes, Samir Awad, Mohammed Moursi, Matthew C Koopmann, Mitchell Sally, Daniel Ihnat, Archana Ramaswamy, Warren Gasper, Edith Tzeng, Mark A Wilson, Gale Tang, Grant Huang, Kousick Biswas
Faculty, Staff and Students Publications
Importance: Postoperative red blood cell transfusion guidelines recommend transfusion for hemoglobin levels less than 7 g/dL. However, the safety of this strategy in patients at high risk of cardiac events undergoing major operations remains unclear.
Objective: To evaluate the risk of death or major ischemic events within 90 days after a liberal transfusion strategy compared with a restrictive transfusion strategy in patients at high risk of cardiac events who had undergone major vascular or general surgery operations and developed postoperative anemia.
Design, setting, and participants: This parallel, single-blind, randomized clinical superiority trial included 1428 veterans (≥18 y) at high cardiac …
Rightly Dividing Jus Ad Bellum And Jus In Bello In The Israel/Hamas War, Jeffrey F. Addicott
Rightly Dividing Jus Ad Bellum And Jus In Bello In The Israel/Hamas War, Jeffrey F. Addicott
Pace International Law Review
No abstract provided.
Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney
Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney
SURE Journal: Science Undergraduate Research Experience Journal
Consumer uptake of a sustainable diet is critical for addressing environmental challenges and promoting public health. Understanding why consumers resist adopting sustainable eating habits can inform targeted interventions and policies. This pilot study examines whether a newly developed scale can effectively detect consumer resistance to a sustainable diet. Currently, there is a lack of research on a tool to measure consumer resistance to a sustainable diet, highlighting the need for a reliable instrument.
The aim of this study is to develop a scale, based on existing literature, to measure consumer resistance to a sustainable diet. Additionally, the study aims to …
The Illusory Privilege Against Self-Incrimination, Kelsey Rohr
The Illusory Privilege Against Self-Incrimination, Kelsey Rohr
Arkansas Law Review
This Note addresses the insufficiency of the current system in protecting criminal defendants’ privilege against self-incrimination. Part II will outline the background legal principles of the issue, including the privilege against self-incrimination, the presumption of innocence, and the no-impeachment rule. This part will also address the Supreme Court’s sole judicial exception to the no-impeachment rule as laid out in Peña-Rodriguez v. Colorado. Part III will address the statistical significance of juror bias against criminal defendants who invoke the privilege, highlight the widespread nature of the bias, and argue that the procedural safeguards currently in place are insufficient to protect.
Culturally Sustaining Literacy Practices: Insights From Pre-Service Educators, Patricia E. Lane
Culturally Sustaining Literacy Practices: Insights From Pre-Service Educators, Patricia E. Lane
Journal of Multicultural Affairs
The research question for this paper is: How does the tenet culturally sustaining pedagogy of the Integrated Teacher Education Program bridge and/or buffer pre-service teachers’ literacy experiences? Through the use of a case study, the researcher examines Integrated Teacher Education Program (ITEP) pre-service educators’ experiences incorporating culturally sustaining pedagogy into the literacy classroom, while also investigating whether these practices serve to bridge and/or buffer pre-service teachers’ experiences (Honig & Hatch, 2004).