Digital Commons Network^™

The Impact Of Targeting Traf2 And Nck-Interacting Protein Kinase On Antitumor Effect And Tumor Immune Environment In C-Myc-High Sclc, Azusa Tanimoto, Kavya Ramkumar, C Allison Stewart, Bingnan Zhang, Kyle Concannon, Robert J Cardnell, Li Shen, Qi Wang, Jing Wang, Carl M Gay, Lauren Averett Byers

Faculty, Staff and Student Publications

Introduction: Wnt/β-catenin signaling pathway activation contributes to tumorigenesis and chemo-resistance in SCLC, yet clinical attempts to target this pathway have been unsuccessful. TRAF2 and NCK-interacting protein kinase (TNIK), an essential nuclear activator of Wnt/β-catenin target genes, has not yet been validated as a viable therapeutic target in SCLC. Here, we validated that TNIK inhibition is a promising approach for personalized anticancer therapy in SCLC.

Methods: We correlated the IC50 values of a TNIK inhibitor, NCB-0846, with proteomic profiling (reverse phase protein array) data across 28 SCLC cell lines. Cytokine array analysis was performed to quantify changes in 105 cytokines after …

Visualizing The Effect Of Process Pause On Virus Entrapment During Constant Flux Virus Filtration, Wenbo Xu, Xianghong Qian, Hironobu Shirataki, Daniel Straus, Sumith Ranil Wickramasinghe

Biomedical Engineering Faculty Publications and Presentations

Virus filtration is an essential unit operation used to validate clearance of adventitious virus during the manufacture of biopharmaceutical products such as monoclonal antibodies. Obtaining at least a 10,000-fold reduction in virus particles in the permeate is challenging as monoclonal antibodies are about half the size of the virus particles. Minute virus of mice, FDA-recommended model adventitious virus, was labeled with a fluorescent dye. Laser scanning confocal microscopy was used to determine the location of virus entrapment within the virus filtration membrane. Three different hollow fiber membranes made of regenerated cellulose and polyvinylidene fluoride were tested. Feed streams consisted of …

Structural Behavior Of Reinforced Concrete Columns Under Eccentric Loads Strengthened By Steel Jackets Filled With Normal And High-Strength Concrete, Mahmoud Ahmed M. Amin, Mahmoud Mostafa El Hawary, Ahmed Shaheen, Ibrahim M. Mashhour

HBRC Journal

Reinforced concrete (RC) columns are essential structural components in buildings and infrastructure, providing vertical load support and stability. However, these columns can be degraded over time due to various factors, such as environmental exposure, seismic events, and increased loading demands. As a result, the need for effective and reliable column-strengthening techniques arises to ensure the safety, durability, and longevity of structures. The main objective of this study is to investigate how fully strengthening damaged columns affects load-bearing capacity and overall structural performance. Moreover, this study tested thirteen reinforced concrete columns during the experimental program. The original dimensions of these columns …

Systemic Sclerosis-Associated Interstitial Lung Disease: Improved Understanding And Advances In Management, Amit Syal, Chris T. Derk

Student Papers, Posters & Projects

Interstitial lung disease (ILD), a common manifestation of systemic sclerosis (SSc), has the highest organ-specific morbidity and mortality, particularly in patients with diffuse cutaneous SSc (dcSSc). Recent advances in diagnostics-including artificial intelligence (AI)-enhanced high-resolution computed tomography (HRCT) and biomarkers such as Krebs van den Lungen (KL)-6-have enabled earlier detection and monitoring of disease progression. Therapeutically, the approval of antifibrotics like nintedanib (NINT) and immunomodulators such as tocilizumab (Toci) has significantly expanded treatment options. Updated international guidelines from the American College of Rheumatology (ACR), American College of Chest Physicians (CHEST), American Thoracic Society (ATS), and European league against Rheumatism (EULAR) now …

Effects Of Video Game Type On Cognitive Performance And Brain Functional Connectivity: A Longitudinal Eeg Study, Jingqing Lu, Ruifang Cui, Lijun Jiang, Chenyu Mu, Weiyi Ma, Diankun Gong, Dezhong Yao

General Human Environmental Sciences Faculty Publications and Presentations

Background: Previous research has shown that video gaming experience is associated with changes in cognitive and perceptual functions as well as neural structure and function. However, how the different types of video games differentially influence cognitive function and neuroplasticity remains unclear. Methods: In this 30-week longitudinal study, participants were randomly assigned to an action video game group or a strategy card game group. Behavioral assessments and resting-state electroencephalography (EEG) recordings were administered at six time points to evaluate changes in attention, working memory, executive function, and their neural correlates. Results: Both groups showed significant improvements in multiple cognitive tasks, but …

Supersaturation Effect And Its Characterization In Gas-Rich Intervals Of Deep Coal Seams, Zhou Lihong, Li Yong, Ding Rong, Li Yun, Li Yongzhou, Kong Jintao

Coal Geology & Exploration

Objective and Method High free gas content serves as a key factor controlling the enrichment and high productivity of deep coalbed methane (CBM). However, its direct determination is challenging, making the accurate identification of free gas-rich coal seam intervals a core scientific issue for efficient exploration and recovery of CBM. This study investigated the Daning-Jixian block (also referred to as the Daji Block) within the Ordos Basin. Based on analyses and tests of the gas content, coal macrolithotype, physical properties, and log responses of cores collected from representative wells through pressure-retained coring, this study systematically assessed the vertical heterogeneity of …

Braingenebot: A Gpt-Engineered, User-Driven Genetic Data Exploration With Polygenic Risk Scores Ranking In Alzheimer’S Disease, Guan Ou, Zhongming Zhao

Faculty, Staff and Student Publications

Background

Polygenic risk scores (PGSs) aggregate the effects of multiple genetic variants to attribute to disease susceptibility, and have been applied to numerous complex diseases including Alzheimer's disease (AD). However, as omics and phenotypic data grow exponentially, reconciling findings across studies with differing ancestral backgrounds, study designs, and statistical methodologies remains a pressing issue. Efficiently extracting biologically relevant insights from this expanding body of data is equally challenging, especially for diseases driven by complex interactions among genetic, environmental, and lifestyle factors.

Method

To address these challenges, we introduce BrainGeneBot, an AI‐driven chatbot framework that automates genetic data analysis and bridges …

Process Activities Of A Neutrosophic-Based Smart Simulation Framework For Islamic Sacred Rituals, Nabil M. Abdelaziz, Mohamad S. Al-Thenyan

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems, Vol. 94, 2025, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez

Neutrosophic Sets and Systems

No abstract provided.

Cover And Content

Turkish Journal of Chemistry

No abstract provided.

Impact Of Physical Activity On Sleep In Adults Recovering From Substance Use Disorders: A Protocol For An N-Of-1 Observational Study, Sascha Thal, Cele Richardson, Joanne Mcveigh, Craig Thompson, Phoebe Wan, Bingyan Pang, Hugh Riddell, Stephen Bright, James Clarke, Bronwyn Myers

Research outputs 2022 to 2026

Introduction Sleep impairments are prevalent among individuals recovering from substance use disorders (SUDs) and are associated with poorer treatment outcomes and increased relapse risk. Physical activity (PA) is known to enhance sleep in general populations, but its day-to-day effects on sleep during SUD recovery remain underexplored, especially across different recovery stages. Methods and Analysis In this observational n-of-1 study, we aim to examine within-person associations between daily PA and sleep quality in three groups of individuals at varying stages of substance use recovery (early treatment, continuing care and long-term recovery). A substudy will validate the agreement between two wearable sleepmonitoring …

Research Advances On Foreign Portfolio Investments: A Bibliometric And Thematic Analysis, Ritu Sapra, Dixit Yadav, Kamal Upreti, Nishant Kumar, Rituraj Jain, Akhilesh Tiwari

Markets, Globalization & Development Review

Foreign portfolio investments have been at the center of research in the finance, economics, and international business domains since the early 1990s when developing economies started to relax their capital account and allowed the entry of foreign investments. Over the years, various macroeconomic (country-specific and global), firm-specific, and quality factors have been studied as determinants in relation to these flows, Still, there is no consensus regarding which factor influences more than the others. This paper uses bibliometric analysis to understand the existing literature to build a solid conceptual base in this research topic. For this study, bibliometric data of 731 …

Effectiveness Of Self-Management Education On Behavior Improvement Among Stroke Survivors In Indonesia: A Randomized Controlled Trial, Yurike Septianingrum, Ratna Yunita Sari, Lono Wijayanti, Rizqa Septiana, Andis Yuswanto, Ah Yusuf, Ika Yuni Widyawati, Nor Aziyan Yahaya

Journal of Health Research

Background: This study aimed to investigate the impact of stroke self-management education (SSME) on improving self-management behaviors among stroke survivors.

Methods: An individual randomized controlled trial was conducted from June to August 2024 in an educational hospital in Surabaya, Indonesia. Participants were selected based on the inclusion and exclusion criteria and then randomly assigned via computer-generated randomization to the intervention and control groups. After 3 weeks of intervention, the self-management behavior of stroke survivors was evaluated using the Stroke Self-Management Behavior Questionnaire (SSMBQ). A per-protocol analysis was used to compare the intervention groups, which included only those patients who completed …

Attitude And Confidence In Managing Pre-Existing Type 2 Diabetes Mellitus During Pregnancy Among Thai Women, Ratchanok Phonyiam, Chiao-Hsin Teng, Catherine S. Sullivan, Aunchalee E.L. Palmquist, Eric A. Hodges, Yamnia I. Cortés, Marianne Baernholdt

Journal of Health Research

Background: The trend of rising T2DM prevalence is more pronounced in females and is of particular concern for pregnancy. The rate has jumped from 0.7% to 1.5% of all pregnancies over the past 14 years. Additionally, pregnancies affected by T2DM have higher rates of abortion and perinatal mortality compared to those with type 1 diabetes mellitus and gestational diabetes mellitus. The objective of the study was to explore the attitudes and confidence in managing T2DM among Thai women during pregnancy.

Methods: This qualitative study was a part of a parent study using a convergent parallel mixed-methods design. A purposive sampling …

A Hybrid Roberta–Rule-Based Aspect-Based Sentiment Analysis Model For Hospital Patient Reviews: Development, Validation, And Case Application In India, Akash Gajanan Prabhune, Karpaga Priya P S, Vinay R Sri Hari, Akhila Rayampalli, Ankur S Thakur, Ebin M Yohannan

Journal of Health Research

Background: Patient Online Reviews (PORs) provide real-time, unsolicited feedback that complements traditional satisfaction surveys. However, existing sentiment analysis tools often handle only monolingual data, broad sentiment categories, or lack review authenticity checks. This study develops a hybrid Aspect-Based Sentiment Analysis (ABSA) model combining RoBERTa with a rule-based aspect detection layer to extract fine-grained sentiment insights from Indian hospital reviews.

Methods: We curated and manually annotated 4,862 Google Maps reviews from 25 Indian hospitals across six aspects—Doctor Behavior, Staff Behavior, Cleanliness, Facility Experience, Cost, and Waiting Time. Though the scheme included positive/negative/neutral labels, the final model used binary polarity (positive vs. …

Prediction Of Lung Vital Capacity Value From Thoracoabdominal Expansion In Young Adults, Aung Myo Htun, Aung Aung Nwe, Chatchaya Jaimanee, Thiwaphon Chatprem, Saowanee Nakmaroeng, Chatchai Phimphasak

Journal of Health Research

Background: Vital capacity (VC) is a fundamental indicator of pulmonary health, but its routine assessment often depends on spirometry devices that may be unavailable (i.e. because of access, cost) in many clinical or community settings. In contrast, lower costal (LC) and upper abdominal (AB) expansions are simple, equipment-free methods commonly used in physiotherapy.

Method: This cross-sectional study was aimed at developing prediction equations for VC using LC or upper AB expansion alongside demographic and anthropometric variables. The study involved 116 healthy nonsmokers (53 male and 63 female individuals) aged 18–39 years. VC was measured via spirometry using a …

Intrapersonal, Interpersonal, And Environmental Factors Associated With Self-Directed Ageism Among Older Thai Adults, Jirawan Wittayanukorn, Piyawat Katewongsa, Yothin Sawangdee, Rossarin Gray, Tawanchai Jirapramukpitak

Journal of Health Research

Background: Self-directed ageism occurs when older adults internalize negative age-related stereotypes, a process that undermines self-esteem, reduces social participation, and leads to poorer health outcomes. Understanding the intrapersonal, interpersonal, and environmental factors that contribute to self-directed ageism is essential for developing more effective interventions to reduce it.

Method: Data were drawn from the Survey on Conditions of Society, Culture, and Mental Health (Thai Happiness) 2014, a nationally representative survey. Managed by checking for completeness, duplicates, and missingness, 8,998 people (aged 60 years and over) were included. Factors associated with self-directed ageism were analyzed using binary logistic regression analysis, taking into …

Absolute Extraction: Utilizing Rural Critical Criminology To Examine Appalachia’S Toxic Dependence On Extractive Industries, Andrew Kennedy

The Mid-Southern Journal of Criminal Justice

Brought forth by common rhetoric, Appalachia is often viewed as the closest space to that of an empyrean domain. Separated from the sleepless city, its allure rests in its created identity of a quiet, green escape from the city, which offers serenity on all fronts. Although Appalachia can fulfill this profile, such an ascension ignores the burning yellow grass below. The purpose of this paper is to examine the history of the destruction of Appalachia through the lens of extractive industries and the region’s designation as a sacrifice zone. Through the application of rural critical criminology, this paper holds that …

Lost In Translation: How Health Literacy Impacts Pharmaceutical Transactions From Healthcare Professionals To Patients, Grace Nwaege

2025 Fall Honors Capstones Projects - Archive

Health literacy is a core element of public health, involving the ability to access, understand, evaluate, and use information to maintain well-being. In the United States, it aligns with an average reading level of about an eighth grader, which continues to decline over time. As pharmacists serve as the final point of contact in most outpatient settings, their ability to communicate effectively at this literacy level is crucial. This study examines how pharmacies address this challenge using qualitative methods, including health literacy assessments of patient consent forms and stakeholder interviews with pharmacy technicians about resource use. Findings show materials higher …

Resting Autonomic Activity, Emotional Reactivity, And Executive Function In Preschool-Age Children Who Stutter, Dana J. Meyerson

Theses - ALL

Purpose: This study investigated whether preschool-aged children who stutter (CWS) differ from children who do not stutter (CWNS) in autonomic physiological reactivity and regulation during a phrase-repetition task paired with affective image-viewing conditions. Additionally, the study investigated whether individual differences in executive function skills, specifically inhibitory control, predicted variability in physiological responses across participants. Methods: Forty-three preschool-aged children (18 CWS, 25 CWNS) completed three laboratory visits that involved collection of electrocardiogram (ECG) recordings at rest and during a phrase-repetition task paired with visual stimuli of either neutral (fixation cross) or negative (IAPS) emotional valence. Inhibitory control was assessed using the …

Intersectionality, Epistemic Injustice, And Silencing: The Operationalization And Reification Of Intersectionality In Academic Research And Institutional Practices, Emery Lockwood

Theses - ALL

Intersectionality is a powerful analytic tool that can be used to better understand the role that oppression plays in society and how it shapes the way people affected by multiple systems of oppression interact with society. Recently, the unit of analysis for intersectionality has started to shift from intersecting systems of oppression to overlapping identities, which has changed intersectionality from being a tool used to analyze systemic oppression to individual’s experiences. This work explores the implications this shift has on academic research and the practice of several disciplines. Using a lens of epistemic injustice through theories of hermeneutical bastardization (Drury, …

Investigating The "Tend-And-Befriend" Stress Response As A Risk Factor For Sexual Victimization Among College Women, Emily Kathleen Presutti

Theses - ALL

Sexual victimization of college women is a significant public health concern on U.S. college campuses. Traditional research on the human stress response has focused on the "fight-or-flight" model, which may not adequately capture female-typical responses in stress-inducing situations. Using a mixed-methods design, we sought to determine whether the "tend-and-befriend" stress response serves as a potential correlate of sexual victimization among college women and examine whether it contributes additional variance beyond established correlates of sexual victimization such as alcohol use, history of sexual victimization, and involvement in campus party culture. The study was conducted in two phases. In Phase I, 128 …

Research On Pavement Roughness Evaluation Method Based On Smartphones, Siriguleng Bai, Yili Guoqi, A Rong, Guo Guoying, Wang Jing

Journal of China & Foreign Highway

To address the low efficiency and high cost of current detection methods,as well as the insufficient accumulation of pavement damage data on rural low-grade roads,this study developed a vehicle vibration data acquisition application based on smartphones and proposed a conversion method for calculating an index equivalent to the international roughness index (IIRI).Vertical acceleration signals collected during vehicle travel were proposed through high-pass filtering and denoising to calculate the vertical displacement,from which a converted I'IRI was derived.Experimental results show that although the data collected by smartphones has slightly lower accuracy than that collected by professional detection equipment,the proposed I'IRI exhibits a …

Surgical Treatment Of Post-Traumatic Elbow Stiffness In Pediatric Patients: A Systematic Review And Meta-Analysis, Roya Khorram, Areeb Ahmad, Reza Vafadar, Ronald Joseph Shamus, Surena Namdari, G. Russell Huffman, Amir R. Kachooei

Rothman Institute Papers

BACKGROUND: Post-traumatic elbow stiffness (PTES) has been reported in up to 21% of pediatric patients following elbow fractures and can profoundly compromise a child's function, and independence. The primary surgical approaches include open and arthroscopic arthrolysis, both of which have demonstrated improvements in range of motion (ROM) and functional scores. This systematic review and meta-analysis aims to compare the effectiveness, ROM, and complication rates between open and arthroscopic release in pediatric patients with PTES.

METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were utilized to conduct a systematic review and meta-analysis on surgical treatment for PTES. Comprehensive …

Intercultural Communicative Competence (Icc) Among Efl Learners And Teachers And The Potential For Ai As A Guide, Zeynep Saka

Theses - ALL

This study investigates the Intercultural Communicative Competence (ICC) of English as a Foreign Language (EFL) students and instructors in Turkey by examining both perceived and observed aspects of ICC, as well as the potential role of Artificial Intelligence (AI) in supporting intercultural communicative competence education. Guided by Byram’s (1997) model and informed by Speech Act Theory (Searle, 1969) and Politeness Theory (Brown & Levinson, 1987), the study adopted a mixed-methods design including 89 students and 46 instructors from nine state universities. Data were collected through a 25-item ICC questionnaire and a series of Discourse Completion Tasks (DCTs) completed under self-guided …

Espacios De Cambio: Evaluating Community-Based Art Therapy Within The Latinx Community, Bennie Guzman

Theses - ALL

This research presented in this graduate thesis explores the social-emotional benefits of community-based approaches of art therapy within the Latinx community. The literature contextualizes the socio-historical experiences of the Latinx community and presents an argument for the use of a community-based approach of art therapy. This study evaluates the social-emotional benefits of the “Arts as Mindfulness” program, an initiative created by the author in collaboration with La Casita Cultural Center at Syracuse University. Methods of data collection include creative reflections and a focus group with program participants. The research conducted data analysis using a hermeneutic phenomenological approach. Themes that arose …

Using A Heuristic Tool To Improve Symptom Self-Management In Adolescents And Young Adults With Cancer: Protocol For A Randomized Controlled Trial., Suzanne Ameringer, Grace Hodges, R K Elswick, Lauri Linder, Catherine Fiona Macpherson, Kristin Stegenga

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Adolescents and young adults (AYAs) with cancer experience multiple distressing symptoms during treatment, yet few developmentally relevant resources have been developed to help them self-manage their symptoms. Empowering patients to have a more active role in self-management during cancer treatment may lessen their symptom severity and distress.

OBJECTIVE: The aim of this study is to test an intervention designed to improve symptom self-management, the Computerized Symptom Capture Tool (C-SCAT), by helping AYAs understand their unique symptom experience and discuss it with their health care providers.

METHODS: We are conducting a multisite, 2-group randomized controlled trial to evaluate the effects …

Mapping Research Trends On Mental Health Literacy Among University Students: A Bibliometric Systematic Review, Eko Pramudya Laksana, Muslihati Muslihati, Arbin Janu Setiyowati, Salsabila Kholifahtun Nisa, Muhammad Nur Hudha, Margaret Kehinde Soetan

Jurnal Kajian Bimbingan dan Konseling

Mental health is a global issue that has received increasing attention, particularly among university students. Mental health literacy (MHL) is an important factor in promoting students' psychological well-being through knowledge, attitudes, and the ability to recognize and address mental health problems. This study aims to map the developmental trends of MHL research among university students in order to provide a comprehensive overview of the direction and focus of studies in this field. This research employed a bibliometric literature review approach by analyzing 48 journal articles indexed in the Scopus database and published between 2021 and 2025. The findings indicate that …

Mobile Markets And Farmers’ Markets: Evaluating Food Accessibility For Underserved Communities In The Bay Area, Rajeshwari Rajesh

Master's Theses

Studies indicate including farmers’ markets, mobile markets, and other local food systems improve fresh food access for low-income communities, especially when paired with food assistance programs that offer financial incentives. This study aims to evaluate mobile markets and farmers’ markets in the Bay Area using the five dimensions of food access: accessibility, availability, acceptability, affordability, and accommodation. The study is based on primary data collected from 173 in-person surveys at six mobile and eight farmers’ markets in the Santa Clara and Contra Costa counties. Key survey participants were market shoppers participating in food assistance programs. A mixed research methodology included …

Variety Of Study Methods In Ophthalmology Residency, Muhammad Rizqy Abdullah, Evelyn Komaratih

Folia Medica Indonesiana

Effective study methods are critical in ophthalmology residency, which must balance cognitive learning with surgical skill development. This systematic review examined non-surgical cognitive strategies and surgical training techniques to inform curriculum design and enhance resident performance. A structured literature search was conducted in PubMed and Scopus (2016–2025) using keywords (“study method” OR “effective study” OR “learning strategy” OR “educational intervention” OR “training approach”) AND (“ophthalmology residency” OR “resident education”). After screening and applying eligibility criteria, 17 studies were included. Methods were categorized as non-surgical (n = 5) and surgical learning (n = 12). This review revealed that non-surgical strategies, including …