Digital Commons Network^™

In Vitro And In Vivo Studies Of Mediator Kinase, Lili Wang

Theses and Dissertations

This project addresses the molecular and in vivo activities of transcriptionregulating module CKM, comprised of CDK8 (or CDK19) kinases, Cyclin C, MED12 and MED13. Our lab has found that CDK8/19 potentiates NFkB-induced transcription. In this study, we confirmed that both CDK8 and CDK19 regulate gene expression in kinasedependent manner. CDK8 and CDK19 are not required for NFkB-induced transcription, which also occurs in HEK293-dKO (CDK8 and CDK19 double knockout) cells, but such transcription becomes CDK8/19-dependent upon re-expression of CDK8 or CDK19 in dKO. Surprisingly. pre-treatment with a CDK8/19 inhibitor decreases the effect of CDK8/19 on NFkB-induced transcription.

In another set of …

Interrogating The Role Of Ing4 In Hematopoietic Stem Cells And Cancer, Zanshé Thompson

Theses and Dissertations

We recently identified the tumor suppressor, Ing4, as a critical regulator of hematopoietic stem cell (HSC) homeostasis. The mis-regulation of Ing4 in human cancers has also been shown to lend malignant cells specific advantages that support carcinogenesis and tumor progression. This activity is, in part, due to Ing4 mediated regulation of overlapping signaling pathways that regulate stem cell activity and cancer cells, including NF-B and c-Myc. In a two-part study, we have investigated the role of Ing4 in murine hematopoiesis and human malignancies. While the specific mechanisms of stem cell self-renewal, maintenance, and differentiation are poorly characterized, we have determined …

Sinclair Lewis Society Newsletter, Vol 30, No. 2, The Sinclair Lewis Society

Sinclair Lewis Society Newsletter

“Backstage with The Life and Loves of Sinclair Lewis“

“Sinclair Lewis Society Announces Virtual Conference for Summer 2022”

“Remembering Daniel Chabris”

“Letter from the Editor: Sinclair Lewis Society Celebrates 30 Years!,” by Sally E. Parry, Illinois State University

“New York Times Book Review Celebrates Lewis and Babbitt“

“Babbitt and Thucydides?,” by Rex Levang

“Significant Writer: Flawed Man: A Review of The Life and Loves of Sinclair Lewis by Bob Beverage,” by Sean C. Denniston

“Sinclair Lewis’s Leading Ladies: Part I: Irene Dunne: Perfect Lady, as Ann Vickers, 1933,” by Susan K. O’Brien

Health Care Services: Utilization And Perception Among Elderly In An Urban Resettlement Colony Of Delhi, Shivani Singh, Somdatta Patra, Amir M Khan

Faculty, Staff and Student Publications

CONTEXT: Health care utilization informs us about the utility of services which are available. We have a paucity of studies related to health care utilization among elderly in India.

AIMS: The aim of this study is to find out utilization of health care services by elderly (≥60 years), pattern, factors associated with, and perception of the elderly population regarding facilitators and barriers for the same.

SETTINGS AND DESIGN: A community based cross-sectional, observational study was conducted in a resettlement colony of East Delhi.

MATERIALS AND METHODS: A pretested, semi-structured, and interviewer-administered questionnaire was used. Duration of data collection was November …

Characteristics And Predictors Of Intensive Care Unit Admission In Pediatric Blunt Abdominal Trauma, Steven C Mehl, Megan E Cunningham, Christian J Streck, Rowland Pettit, Eunice Y Huang, Matthew T Santore, Kuojen Tsao, Richard A Falcone, Melvin S Dassinger, Jeffrey H Haynes, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David Mooney, Jeffrey Upperman, Martin L Blakely, Adam M Vogel

Faculty, Staff and Student Publications

BACKGROUND: Pediatric trauma patients sustaining blunt abdominal trauma (BAT) with intra-abdominal injury (IAI) are frequently admitted to the intensive care unit (ICU). This study was performed to identify predictors for ICU admission following BAT.

METHODS: Prospective study of children (< 16 years) who presented to 14 Level-One Pediatric Trauma Centers following BAT over a 1-year period. Patients were categorized as ICU or non-ICU patients. Data collected included vitals, physical exam findings, laboratory results, imaging, and traumatic injuries. A multivariable hierarchical logistic regression model was used to identify predictors of ICU admission. Predictive ability of the model was assessed via tenfold cross-validated area under the receiver operating characteristic curves (cvAUC).

RESULTS: Included were 2,182 children with 21% (n = 463) admitted to the ICU. On univariate analysis, ICU patients were associated with abnormal age-adjusted shock index, increased injury severity scores (ISS), lower Glasgow coma scores (GCS), traumatic brain injury (TBI), and severe solid organ injury (SOI). With multivariable logistic regression, factors associated with ICU admission were severe trauma (ISS > 15), …

Mrna Coronavirus Disease 2019 Vaccine-Associated Myopericarditis In Adolescents: A Survey Study, Utkarsh Kohli, Lavina Desai, Devyani Chowdhury, Ashraf S Harahsheh, Alexandra B Yonts, Annette Ansong, Arash Sabati, Hoang H Nguyen, Tarique Hussain, Danyal Khan, David A Parra, Jennifer A Su, Jyoti K Patel, Christina Ronai, Monique Bohun, Bishara J Freij, Matthew J O'Connor, Joseph W Rosanno, Aamisha Gupta, Arash Salavitabar, Adam L Dorfman, Jesse Hansen, Olivia Frosch, Elizabeth L Profita, Shiraz Maskatia, Deepika Thacker, Shubhika Shrivastava, Tyler H Harris, Brian Feingold, Stuart Berger, Michael Campbell, Salim F Idriss, Srikant Das, Markus S Renno, Ken Knecht, S Yukiko Asaki, Sunil Patel, Ravi Ashwath, Renata Shih, John Phillips, Bibhuti Das, Preeti Ramachandran, Eyal Sagiv, Aarti H Bhat, Jonathan N Johnson, Nathaniel W Taggart, Jason Imundo, Natasha Nakra, Shashank Behere, Anjlee Patel, Avichal Aggarwal, Saif Aljemmali, Sean Lang, Sarosh P Batlivala, Daniel E Forsha, Gregory P Conners, Jana Shaw, Frank C Smith, Linda Pauliks, Joseph Vettukattil, Kenneth Shaffer, Stefanie Cheang, Sonia Voleti, Rajesh Shenoy, Rukmini Komarlu, Shea J Ryan, Christopher Snyder, Neha Bansal, Madhu Sharma, Jeffrey A Robinson, Sandra R Arnold, Christine M Salvatore, Madan Kumar, Michael A Fremed, Julie S Glickstein, Melissa Perrotta, William Orr, Tamika Rozema, Muthayipalayam Thirumoorthi, Charles J Mullett, Jocelyn Y Ang

Faculty, Staff and Student Publications

In this survey study of institutions across the US, marked variability in evaluation, treatment, and follow-up of adolescents 12 through 18 years of age with mRNA coronavirus disease 2019 (COVID-19) vaccine-associated myopericarditis was noted. Only one adolescent with life-threatening complications was reported, with no deaths at any of the participating institutions.

Survey Of Pediatric Critical Care Fellows On Postresuscitation Debriefing, Nicholas A Rossi, Mia Benavidez, Harold S Pine, Shiva Daram, Wasyl Szeremeta

Faculty, Staff and Student Publications

Choanal atresia is a rare congenital airway malformation that presents a unique surgical challenge for pediatric otolaryngologists. Here we report two classic cases of choanal atresia and examine the surgical approaches to this entity. The first case was a four-day-old female with a history of CHARGE syndrome and bilateral mixed membranous and bony choanal atresia confirmed by a CT scan. After undergoing transnasal endoscopic repair, choanal stents were placed for four weeks, and the patient was seen three months postoperatively and found to be doing well with no respiratory concerns. The second case involved a healthy three-year-old female presenting with …

Data Source Selection In Federated Learning: A Submodular Optimization Approach, Ruisheng Zhang, Yansheng Wang, Zimu Zhou, Ziyao Ren, Yongxin Tong, Ke Xu

Research Collection School Of Computing and Information Systems

Federated learning is a new learning paradigm that jointly trains a model from multiple data sources without sharing raw data. For the practical deployment of federated learning, data source selection is compulsory due to the limited communication cost and budget in real-world applications. The necessity of data source selection is further amplified in presence of data heterogeneity among clients. Prior solutions are either low in efficiency with exponential time cost or lack theoretical guarantees. Inspired by the diminishing marginal accuracy phenomenon in federated learning, we study the problem from the perspective of submodular optimization. In this paper, we aim at …

A Review Of Standardized Testing And Its Relevance To Public Education, Johnny Salinas, Cassia Guajardo

Teaching and Learning Faculty Publications

In this paper, we seek to understand the complexity of standardized testing while promoting the inclusion of cultural representation within the current curriculum and effects. In the past decades South Texas schools have been forced to use standardized testing as a form of teacher and student classroom assessment. Good measurement and classroom management for the improvement of teachers and students’ achievement levels need to be supported with other styles forms of testing. Our methodology is based on the analysis of literature and current strategies. The significance of this study is to implement possible enhancements to the current curriculum and testing. …

Papal Blessing

Spiritan Horizons

No abstract provided.

The Nephrocheck Bedside System For Detecting Stage 3 Acute Kidney Injury After Open Thoracoabdominal Aortic Repair, Mark Hwang, Michael H Weisman

Faculty, Staff and Student Publications

No abstract provided.

Decree Of Erection Of The Province: Decree Of November 16, 1873

Spiritan Horizons

No abstract provided.

Superior General’S Message, Alain Mayama C.S.Sp.

Spiritan Horizons

No abstract provided.

Usd Magazine Spring 2022, University Of San Diego

University of San Diego Magazine (1992- )

Torero News; Torero Athletics; The Philanthropists; The Team Builder; The Enthusiast; Class Notes

2022 April, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for April of 2022.

Decolonizing My Classroom During The Covid-19 Pandemic: An Autoethnographic Study, Nadia Khan-Roopnarine

Theses & Dissertations

American schooling is a colonized construct that seeks to maintain white patriarchal hegemony (Battiste, 2013). As a critical educator whose personal epistemologies are shaped by Indo-Caribbean feminism and Coolie feminism, I continually grapple with a large bureaucratic system that thrives on the perpetual dehumanization of teachers, families, and students. The sudden shift to remote learning surfaced the particular cognitive dissonance I navigate, both within myself and in my professional spaces, as I work to decolonize my classroom spaces while inadvertently perpetuating them.

As a high school English teacher serving a population of exclusively BIPOC students in a small urban school, …

“...Reveling In That Freedom”: Roxane Gay’S Hunger As 21st-Century Freedom Narrative, Kendra R. Parker

Literature: Faculty Publications

Work published in South Atlantic Review.

Pilot Trial Of A Technology Assisted Treatment For Trichotillomania, Jordan T. Stiede, Douglas W. Woods, Aneela K. Idnani, John Pritchard, Kirk Klobe, Sameer Kumar

Psychology Faculty Research and Publications

The present study examined the usability, acceptability, feasibility, and preliminary efficacy of a prototype wrist-worn motion detection device and accompanying mobile app, developed by HabitAware®, as a system for delivering self-administered Habit Reversal Training (HRT). As an exploratory aim, the effect of the device and HRT app combination was compared to a reminder bracelet. The pilot trial included 15 adults with trichotillomania who interacted with the device and app system (n = 10) or reminder bracelet (n = 5) for 4 weeks. Participants in the device and app condition reported high usability, acceptability, and perceived efficacy of the …

Cultural Adaptation Profiles Among Mexican-Descent Latinxs: Acculturation, Acculturative Stress, And Depression., Mark W. Driscoll, Lucas Torres

Psychology Faculty Research and Publications

Objectives: Person-centered analysis was used to examine profiles of acculturation and acculturative stress among Mexican-descent adults in relation to depression. It was hypothesized that identified profiles would support multiple acculturation styles, that acculturation profiles would differentially relate to acculturative stress dimensions, and that those profiles with greater Latinx acculturation and lower acculturative stress would report less severe depression. Method: Mexican-descent Latinx adults (n = 230) completed self-report measures of Latinx and Anglo acculturation, acculturative stress, and depression symptom severity. Latent profile analysis was used to derive acculturation–acculturative stress profiles. Results: Three distinct profiles emerged. One profile was notable for …

Text Analysis Of Airline Tweets, Essa Altamimi

Theses

By acting as a succinct summary, keywords and key phrases can be a useful tool for swiftly assessing enormous amounts of textual material. A "keyword" is defined as a "word that briefly and accurately characterises the subject, or an aspect of the subject, presented in a text," according to the International Encyclopaedia of Information and Library Science (Bolger et al., 1989) (Feather et al., 1996). People are more likely to complain when they are anxious, according to research (Bolger et al., 1989)(Meier et al., 2013), and moods are affected by time (Ryan et al., 2010). Due to this study, airlines …

Perceptions Of Secondary Music Educators On The Transition To, And First Years Of The Every Student Succeeds Act, Thomas Rizzuto

Theses & Dissertations

The Every Student Succeeds Act (ESSA) of 2015 has the potential to be important for American music education. Unlike its predecessor, No Child Left Behind (NCLB), ESSA mentions music by name as one of the components of a “well-rounded education,” rather than including it under the arts. However, there is much that is unknown about ESSA and how it pertains to music education. The purpose of this qualitative case study was to better understand the perceptions of music educators on the transition to and the first years of ESSA. The primary source of data included 18 semi-structured interviews with secondary …

The Gay Agenda: Being Accepted In Children’S Media, Tiffany Wells

Honors College Theses

For many LGBTQ+ children, there is a lack of representation of their identities in the television shows they see growing up. We turn to objects, like television characters, to help “find our way,” which becomes limited for individuals who are part of the minority (Ahmed 1). When television shows reflect a variety of lived experiences, they can increase cultural competence in their viewers. While LGBTQ+ representation in children’s media has increased, it is still difficult to implement such representation. This thesis we will discuss three shows, Gravity Falls, Steven Universe, and The Owl House, that have struggled with the implementation …

Rescuecastr: Exploring Photos And Live Streaming To Support Contextual Awareness In The Wilderness Search And Rescue Command Post, Brennon Jones, Anthony Tang, Carman Neustaedter

Research Collection School Of Computing and Information Systems

Wilderness search and rescue (WSAR) is a command-and-control activity where a Command team manages field teams scattered across a large area looking for a lost person. The challenge is that it can be difficult for Command to maintain awareness of field teams and the conditions of the field. We designed RescueCASTR, an interface that explores the idea of deploying field teams with wearable cameras that stream live video or sequential photos periodically to Command that aid contextual awareness. We ran a remote user study with WSAR managers to understand the opportunities and challenges of such a system. We found that …

The Politics Of Bank Opacity, Heng Yue, Liandong Zhang, Qinlin Zhong

Research Collection School Of Accountancy

The distribution of power in the political system shapes the financial reporting opacity of banks. Specifically, banks located in states with senators on the Senate Banking Committee (BC senators) have greater abnormal loan loss provisions than banks in other states. The result is stronger for larger banks and banks with higher risk. In addition, BC senators have a negative effect on the likelihood of banks in their home states receiving enforcement actions, and, more importantly, this effect is stronger for more opaque banks. These findings suggest that politicians, regulators, and banks use opaque financial reporting to facilitate regulatory forbearance. Moreover, …

Developing Future-Ready Talent Through ‘Real-World’ Digital Projects, Gary Pan, Benjamin Huan Zhou Lee, Yuanto Kusnadi

Research Collection School Of Accountancy

A close collaboration between university and industry partners through ‘real-world’ digital projects could help develop future-ready accountants

Non-Gaap Earnings And Stock Price Crash Risk, Charles Hsu, Rencheng Wang, Benjamin C. Whipple

Research Collection School Of Accountancy

We investigate whether non-GAAP earnings disclosures increase stock price crash risk. Consistent with non-GAAP disclosures allowing managers to inflate investors' perceptions about firm performance, our results indicate that income increasing non-GAAP reporting increases crash risk. We also find that managers can use non-GAAP reporting as a substitute for earnings management to withhold bad news from investors (the traditional explanation for crashes). Finally, we find a positive association between non-GAAP reporting and the likelihood of subsequent events that can trigger a crash. Overall, our evidence is consistent with some non-GAAP disclosures exposing investors to risks of large and sudden price declines.(c) …

Executive Function Moderates The Effect Of Reappraisal On Life Satisfaction: A Latent Variable Analysis, Wei Xing Toh, Hwajin Yang

Research Collection School of Social Sciences

Emotion regulation strategies, such as reappraisal and suppression, have been shown to dissimilarly affect life satisfaction. Specifically, reappraisal is linked to higher life satisfaction, while suppression is associated with lower life satisfaction. Less is known, however, about the potential moderators of these established relations. Given that reappraisal and suppression are contingent, in part, on executive function (EF), which comprises a group of adaptive, goal-orientated control processes (i.e., inhibitory control, working memory, and shifting), we explored whether different components of EF could moderate the impact of reappraisal and suppression on life satisfaction. Using latent moderated structural equation analyses, we found that …

Borderline Personality Traits And Romantic Relationship Dissolution, Kenneth Tan, Samantha H. Ingram, Laura Anne Lau, Susan South

Research Collection School of Social Sciences

Many studies have found that borderline personality disorder (BPD) is associated with romantic relationship instability, with relationship dissolution being a recurring theme. Scant research, however, has examined the dissolution strategies and post-breakup outcomes for individuals with elevated levels of borderline traits. Findings from two studies revealed that there was an association between BPD criteria and tendency to employ less adaptive dissolution strategies when terminating a relationship. Furthermore, elevated levels of BPD traits were associated with less self-concept clarity and more unwanted pursuit of ex-partners. These findings both provide insight into how individuals with BPD traits experience relationship dissolution and suggest …

Important To Me And My Society: How Culture Influences The Roles Of Personal Values And Perceived Group Values In Environmental Engagements Via Collectivistic Orientation, Tengjiao Huang, Angela K. Y. Leung, Kimin Eom, Kam Pong Tam

Research Collection School of Social Sciences

Despite extensive works examining the influence of personal values on environmental engagements, scarce research has examined the influence of group values that are perceived as important in the society. To address this lacuna and recent calls for more cross-cultural environmental research, we investigated whether and how culture, via collectivistic orientation, influences the roles of personal values and perceived group values, namely egoistic and biospheric values, in motivating environmental engagements in a Western (the U.S.; N = 469) and an Asian (Singapore; N = 410) country. To highlight a few findings, the study showed that personal values and perceived group values …

Class(Ify)Ing Christianity In Singapore: Tracing The Interlinked Spaces Of Privilege And Position, Orlando Woods, Lily Kong

Research Collection School of Social Sciences

This paper considers how two facets of identity – religion and class – are performed, (re)produced and negotiated within the spaces of the Christian school, home and church in Singapore. We show how the social structuring of one space can inform and influence the structuring of another. Spaces of Christianity in Singapore tend to be mutually reinforcing, strengthening the linkages between religion and class, and in particular reifying the position of Christianity as a religion of the privileged classes. However, the ways in which Christian spaces are reified can become problematic when space is in fact shared with less privileged …