Digital Commons Network^™

Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood

Faculty, Staff and Students Publications

Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells with hypersensitivity to a PAINS-like small molecule, MCB-613. Systematic proteomic, functional genomic, and biochemical studies revealed that MCB-613 binds KEAP1 in a covalent, cysteine-independent fashion, acting as a divalent molecular bridge that relies upon lysine residues in the KEAP1 dimerization domain to join monomers of KEAP1 together. Oligomerization of KEAP1 by MCB-613 sets into motion a fatal cascade of KEAP1 …

A Case Comment On Cryogas Equipment V. Inox India, Eashan Ghosh

Indian Journal of Law and Technology

Composite claims for copyright and design have long posed conceptual difficulties under Indian law. A pointed attempt by the Supreme Court in Cryogas Equipment v Inox India (‘Cryogas’) to resolve these difficulties, therefore, is of considerable interest.

In this Comment, I examine Cryogas in detail. I find that, despite adopting a schematic approach that is promising on the surface, Cryogas offers little assistance in untangling the constituent portions of copyright-design claims. For one, its test for telling apart artistic works from designs is entirely self-referential and requires a pre-existing understanding of what outputs statutorily constitute ‘artistic works’ and …

Chatgpt Goes To (National)Law School, Rahul Hemrajani, Vedant Gupta, R Srivatsan, Radhika Singhal, Krishne Tanneerbavi, Shristy Chhaparia, Siddharth Johar, Srujan Sangai, Suvanssh Mahajan, Priyansh Dixit, V Sreedharan, Dhruv Holla, Gunjan Modi, Kajal Jamdare, Pratyay Amrit, Sannah Mudbidri, Ishaan Goel, Akshit Singla, Arjun Mehta, Madhav Mitruka, Mannat Mahaey, Nathaniel Warjri, Swapnil Das, Ojas Chandaniha, Yash Ahirwar, Animesh Tiwari, Aman Meena

Indian Journal of Law and Technology

This paper presents the first comprehensive empirical evaluation of Large Language Models’ (‘LLMs’) performance in Indian legal education. We compare six Artificial Intelligence (‘AI’) chatbots with law students at the National Law School of India University, Bengaluru, across four subjects: Contract Law, Corporate Law, Criminal Procedure, and Jurisprudence. Our findings show that LLMs achieve performance comparable to human students (B+ grade), with newer commercial models consistently outperforming older and open-source alternatives. We also find that while LLMs excel in theoretical subjects and structured legal analysis, they show limitations in handling jurisdiction-specific knowledge and complex scenario-based reasoning. These findings have important …

Ever Onward: The Frontier Myth And The Information Age, Jack Shuler

Fast Capitalism

No abstract provided.

E-Mail: Connections, Contexts, And Another Space, Terry Caesar

Fast Capitalism

No abstract provided.

Media Culture And The Triumph Of The Spectacle, Douglas Kellner

Fast Capitalism

No abstract provided.

Timescapes Of The Network Society, Robert Hassan

Fast Capitalism

Since the late ‘70s, the mutually reinforcing interaction between neoliberal economics and the revolution in information and communication technologies (ICTs) has transformed the world in many ways. “Globalization” is what we have come to call this process, and many aspects of its profound effect have been analyzed from a range of perspectives (e.g. Appadurai 1990; Robertson 1993; Omahe 1993; Waters 1995; Bauman 1998; Steger 2003). This paper discusses a central element of this change through globalization that has so far received relatively little attention—our relationship with time and how this is changing, in turn, the nature of power and politics. …

About The Authors, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

C. Wright Mills: A New Left For A New Day, Charles Lemert

Fast Capitalism

Thomas Paine, during a crucial moment in the American war against its colonizers, said famously: “These are times that try men’s souls.” Many think, I among them, that these too are times that try men’s souls. At such a time, one must look back for clues as to what to think and do. One from not that long ago who lends us wisdom of a sort is C. Wright Mills, who in the 1950s, tried to make sense of America’s changing culture. However, a bad heart killed him in 1962, just after he wrote of the possibility of a New …

Of The Enemy: Scalping As Culture And Commodity On The North American Frontier, James Sandy

Fast Capitalism

In a February 1711 letter home, John Barnwell recounted his campaign’s recent victories in the raging Tuscarora War. Fighting in the western reaches of colonial North Carolina, Barnwell and a group of South Carolina militiamen marched from one Tuscarora village to the next in search of Native American warriors to kill and civilians to harass, enslave, or otherwise brutalize. John “Tuscarora” Barnwell was thorough in his recollection of their campaign, going to great lengths to describe their “valient” task. Barnwell, like many other frontiersmen and militia commanders of his generation, added a flair for the dramatic to his retelling of …

Fighting For Justice In The Neoliberal University: The Promise Of Reflexive And Flexible Solidarity, Timothy Gibson, Bethany Letiecq

Fast Capitalism

In the neoliberal university, faculty are encouraged to build strong connections in virtually every way except one: as workers. In this paper, we will discuss our experiences as leaders of the XXX chapter of the American Association of University Professors, with a focus on our campaign to build across-campus labor coalition connecting faculty, students, staff, and contract workers in the struggle for economic and social justice. We will begin by examining the constellation of structural forces and professional hierarchies that amplify labor exploitation on campus, subvert shared governance and academic freedom, and cultivate a campus culture of disconnection, competition, and …

Full Issue, Fast Capitalism Editorial Team

Fast Capitalism

No abstract provided.

“Rise Of The Resistance” And The Demise Of Social Being: The Autolysis Of Subjectivity In The Twenty-First Century, Reha Kadakal

Fast Capitalism

Structural transformations in the 21st century necessitate radical rethinking of the category of subject that underlie the notions of autonomy, agency and individuality. This paper depicts an onto-genetic transformation of the subject— its autolysis—in the historical present by building on representations and the mediation of categories of social life. The paper first delineates the notion of representation as a central element of critical ontology as a form of social theory by building on Hegel and Durkheim. It then draws on a recent product from the culture industry, namely The Disneyland theme-park ride called “Rise of the Resistance,” which involves a …

The Artificiality Of Digital Scarcity: Contradictions Between Code, Law, Norms, And Value(S), Anthony Jack Knowles

Fast Capitalism

The rise and fall of Napster represented a major turning point in the history of the internet as it simultaneously paved the way for peer-to-peer filesharing as well as ushered in a backlash from incumbent media companies backed by an army of lawyers. This essay grapples with the ramifications of this struggle against filesharing and piracy that forever changed the internet. Much of how and why the internet is structured as it is can be explained through recognizing that this contradictory state of affairs is due to the inherent properties of the internet and digital files when "forced" to fit …

Napster's Mediations, Gavin Mueller

Fast Capitalism

While Napster has often been understood as a force for disintermediation, this essay examines three possible levels that Napster could be theorized as engaged in mediation: the level of protocol, the level of interface, and the level of culture. Each has implications for how we understand the politics of Napster, and peer-to-peer more generally.

Napster "Freedom" At Northeastern University: A Distanced Ethnography, Marcus Breen

Fast Capitalism

This article offers a critical first hand account, from an academic at Northeastern University after Napster's creator Sean Fanniong left the campus in 1999. Reflecting on the impact of Fanning on the campus, drawing on the history of community computer innovation in Boston as a means of activism, the article identifies through Marx, the way monopoly capitalism destroyed Napster's capacity for free music culture. The impact of Intellectual Property law in shutting down digital innovations such as Napster, is considered for the impact it had on the ideals of the liberal university in the United States.

The Shadows Of Wealth, David Mcclough

The Journal of Economics and Politics

No abstract provided.

Threads Of Empathy: An Integrative Model Of Empathy In The Schools, Arthur J. Clark, Tara M. Simpson

Journal of Human Services Scholarship and Interprofessional Collaboration

Empathy has a distinctive and evolving history in education for cultivating human relationships and engendering mutual understanding. Within a school setting, empathic engagement is essential for the social and emotional development of children and adolescents. From an educational perspective, literature from multiple disciplines and specialties illustrate innovative practices to harness empathy in the classroom and beyond. The representative initiatives hold promise for developing an integrative model of empathy within a school or a school district through a program involving interprofessional collaboration.

Assessing The Impact Of Visitors On Airborne Particle Deposition In The Giant Gypsum Geode Of Pulpí (Se Spain), Ana Camila Mendoza, Ángel Fernández-Cortés, Fernando Gázquez, Jesús Morilla, Milagros Carretero, Jose Maria Calaforra, David Benavente

International Journal of Speleology

The Giant Geode of Pulpí is a unique mineralogical phenomenon worldwide, remarkable for its large selenite gypsum crystals. Its recent development as a tourist site and inclusion on UNESCO’s Tentative World Heritage List, highlight the need to assess the impact of visits on its conservation. This study investigates airborne particle dynamics inside the Geode, focusing on tourist activity and natural ventilation. We measured deposition rates and composition of airborne particles using passive traps and a continuous laser-optical particle counter. Microenvironmental variables linked to ventilation, such as temperature and radon gas concentration (²²²Rn), were simultaneously monitored. Results show a predominance of …

Influence Of Co2 Curing On Carbonation Depth, Phase Composition, And Micro-Mechanical Properties Of Fbc Ash-Blended Cementitious Materials, Heejung Jun, Seongho Han, Sanghwon Wi, Jinyoung Yoon

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This study investigates the physicochemical and mechanical performance of cementitious composites incorporating fluidized bed combustion (FBC) ash under accelerated carbon dioxide (CO₂) curing. FBC ash, due to its high contents of free calcium oxide (CaO) and sulfate (SO₃), has been reported to cause challenges, such as volume instability and lower early-age strength. To address these limitations, CO2 curing was applied to promote accelerated carbonation and stabilize the hydration products. Cement paste and mortar samples, made with up to 40 % by cement weight replacement with FBC ash (labelled CF), were subjected to either CO₂ curing …

Industrial Metal Supply Shocks And Heterogeneous Macroeconomic Effects: Evidence From Copper, Andrea Bastianin, Luca Rossini, Alessandra Testa

Fondazione Eni Enrico Mattei Working Papers

This paper studies the macroeconomic effects of global copper supply shocks. We identify exogenous disruptions to copper supply using a Bayesian structural VAR of the world copper market that combines sign and narrative restrictions. We then trace the international transmission of the identified shock using a two-step approach based on country-level models for major copper-importing and exporting economies. We find that copper supply shocks raise producer prices and depress industrial activity in importing economies, while exporters benefit from higher world prices through improved terms of trade. Importer-exporter status alone is insufficient to characterize exposure: heterogeneity in responses reflects differences in …

Classroom To Campus: A Qualitative Case Study Of Exemplary First-Year Seminar Instructors In Student Transitions At A Louisiana University, Brianna J. Doucet

Doctoral Dissertations

This qualitative case study examined how exemplary first-year seminar (FYS) instructors design and implement pedagogical strategies that support students’ transitions into higher education through the lens of Schlossberg’s (1981) Transition Theory. Conducted at a public university in Louisiana, the study explored how university-identified, award-winning instructors foster academic, social, and emotional adjustment among first-year students, a critical priority amid the impending enrollment cliff and the growing need to retain enrolled students. Using semi-structured interviews and thematic analysis, findings revealed exemplary instructors design intentional, relational, and reflective learning environments. They view transition as a shared institutional process, model adaptability and lifelong learning, …

Optimized Photoemission From Organic Molecules In 2d Layered Halide Perovskites, Muhammad S. Muhammad, Dilruba A. Popy, Hamza Shoukat, John M. Lane, Neeraj Rai, Vojtěch Vaněček, Zdeněk Remeš, Romana Kučerková, Vladimir Babin, Chenjia Mi, Yitong Dong, Mark D. Smith, Novruz G. Akhmedov, Daniel T. Glatzhofer, Bayram Saparov

Faculty Publications

In recent years, hybrid organic–inorganic metal halides have been at the forefront of materials research. Typically, the functional (e.g., optoelectronic) properties of hybrid halides are derived from the inorganic structural part, whereas the organic structural units can add extra advantages in terms of stability, rigidity, and processability. Here, we report the design, synthesis, and characterization of two new hybrid materials in which the outstanding photophysical properties originate from the organic structural part. The new compounds, (C₁₅H16N)₂CdCl₄ and((Br)C₁₅H₁₅N)₂CdCl₄, have 2D layered Ruddlesden–Popper-type perovskite structures. These hybrids are blue-white …

Disease Burden Of Asthma Patients Utilizing Short-Acting Beta-2 Agonist-Only Inhalers As Rescue In The United States, Njira Lugogo, Rena C. Moon, Yen Chung, Joy David, Omar Motawakel, Ning A. Rosenthal, Neil Skolnik

Department of Family & Community Medicine Faculty Papers

Purpose: We aimed to describe the disease burden of asthma and examine relationships between short-acting beta-2 agonist (SABA) use and asthma exacerbations. Patients and Methods: This retrospective cohort study used geographically diverse Premier Healthcare Database (PHD) and linked insurance claims (10/01/2021-09/30/2022) for US patients aged ≥18 years with a SABA-only prescription and a history of asthma exacerbation within 12 months before index date (the earliest SABA prescription date). Three asthma control groups were defined based on SABA usage: well controlled-low (0–1 prescriptions), not well controlled-medium (2–3 prescriptions), very poorly controlled-high (≥4 prescriptions). Four asthma severity groups were defined using asthma …

Regeneration Of Swimming Antennae After Partial Amputation In Long- And Short-Lived Daphnia, Charles Schumpert, Rekha C. Patel, Jeffry L. Dudycha

Faculty Publications

Regeneration, the ability of an animal to restart a developmental process and thus rebuild itself following injury or loss, is generally thought to be inversely related to aging, the progressive decline of organismal functions and fitness that occurs as adults get older. We sought to test whether recently evolved differences of aging in the crustacean Daphnia were accompanied by evolutionary divergence of regenerative ability. Using the short-lived D. pulex and the long-lived D. pulicaria, we conducted an assessment of regenerative ability in which we amputated part of the swimming antenna and observed subsequent regeneration. In four clones isolated from …

Jwst Interferometric Imaging Reveals The Dusty Torus Obscuring The Supermassive Black Hole Of Circinus Galaxy, Enrique Lopez Rodriguez, Joel Sanchez-Bermudez, Omaira González-Martín, Robert Nikutta, Ryan M. Lau, Deepashri Thatte, Julien H. Girard, Ismael García-Bernete, Matthew J. Hankins

Faculty Publications

The dusty and molecular torus is an elusive structure surrounding supermassive black holes, yet its importance is unequivocal for understanding feedback and accretion mechanisms. The torus and accretion disk feed the inspiraling gas onto the active nucleus, launching outflows that fundamentally connect the active nucleus’s activity to the host galaxy. In this work, we utilize the aperture-masking interferometric mode onboard the JWST to achieve a resolution of 0.08" at 4.3 μm and bring out the fainter features in the central 10 pc of the Circinus galaxy. We show that most of the dust mass is located along the equatorial …

Respiratory Health And Environmental Risks Among California Children: The Role Of Socioeconomic Status, Wen Chieh Chia

Walden Dissertations and Doctoral Studies

Abstract Air pollution has been cited as a factor in the development of respiratory illness in children. Socioeconomic differences can intensify the effects of air pollution exposure on low-income children compared to higher-income children. This correlational study examined the relationship between air pollution exposure and respiratory health outcomes among California children, as well as the moderating role of socioeconomic status. The study was guided by the environmental health disparities framework and used secondary data from the California Environmental Health Tracking Program, analyzing data from 49 California counties (n = 49). Independent variables were PM2.5 concentrations and the number of ozone …

Contact Binary Stars: A Roadmap To Their Nature And Evolution, Larry A. Molnar, M. Chalov, R. Deaton, R. Reynolds

University Faculty Publications and Creative Works

A complete life cycle for W UMa systems

• Mass transfer from secondary driven by primary
• Sign of flow essential to stability criteria 
• Consistent with observations of distributions of M, T, P, q, dP/dt, (P,q)merger

Ongoing

• THEORY 
• Understand f distribution 
• Compute grid of models to compare with populations of various ages • 

OBSERVATION:Rubin observatory data

• Establish parameter distributions vs. location or kinematics 
• Find the next red nova before it explodes

Public Perspectives On Sharing Profits With Biospecimen Donors, Aaron Eli Segal, Xiaobai Li, David Wendler

Faculty and Staff Publications

Introduction: In current practice, individuals rarely share in the profits of research using their biospecimens. Many commentators defend this practice on the grounds that the contributions donors make are not important enough to merit a share of the profits. Others argue that if researchers and sponsors profit, donors should too. Despite the importance of this debate, there are no data on the public’s views. Methods: Online survey of US adults selected to approximate the 2020 US census on age, gender, race, ethnicity, and geographic region. Respondents were asked whether biospecimen donors should share in the profits or receive payments across …