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Potential Energy Landscape Formalism For Quantum Liquids, Yang Zhou Sep 2026

Potential Energy Landscape Formalism For Quantum Liquids, Yang Zhou

Dissertations, Theses, and Capstone Projects

Atomic delocalization due to nuclear quantum effects (NQE) remains poorly understood in low-temperature liquids near the glass state and during vitrification. Many liquids can be described accurately by treating their nuclei as classical particles, but this approximation fails for light elements such as He and H₂, small hydrogen-containing molecules such as water, and systems in which zero-point motion or isotope-substitution effects are important. Developing a general thermodynamic and statistical-mechanical description of such liquids has been challenging. This dissertation extends the potential energy landscape (PEL) formalism, originally developed for classical liquids and glasses, to liquids that obey quantum mechanics and exhibit …


The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose Sep 2026

The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose

Dissertations, Theses, and Capstone Projects

Tobacco is one of the most widely used substances across the United States; tobacco consumption is linked with several diseases and is one of the leading causes of preventable death in the country. Nicotine is the active substrate found in tobacco products, acting as a stimulant, which reinforces continued use. The introduction of tobacco-free options such as e-cigarettes and oral pouches has driven an increase in nicotine exposure across the population, especially in young adults. Acute nicotine use induces neuroadaptations in the mesolimbic dopaminergic system, which mediates reinforcement learning and addiction, that potentiates reward-related neurotransmission. Furthermore, there are clinical studies …


Optimizing Nanoparticle Quality And Function In Applied Research, Angela M. Fried Sep 2026

Optimizing Nanoparticle Quality And Function In Applied Research, Angela M. Fried

Dissertations, Theses, and Capstone Projects

Radiology tests are among the fastest-growing categories of diagnostic analysis, and the gold standard of radiology tests is MRI.  MRI can be more informative if a contrast agent is used, and the standard of care contrasting agents (CA) are gadolinium-based.  Gadolinium is a heavy metal, toxic, and contraindicated for renal-compromised patients and the critically ill.  We propose a nanogel (NG) vehicle for an alternative organic CA.  CNs like 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) and its derivatives have a variety of medical and industrial uses.  These cyclic CNs are stable, synthetic radicals with distinctive EPR/ESR signals and are helpful for various experimental applications, from …


Mapping The Water Quality Of Jamaica Bay, New York (1996-2024): Principal Component Analysis And K-Means Clustering, Sneha Srivastava Sep 2026

Mapping The Water Quality Of Jamaica Bay, New York (1996-2024): Principal Component Analysis And K-Means Clustering, Sneha Srivastava

Dissertations, Theses, and Capstone Projects

Jamaica Bay, located along the southeastern coast of New York City, acts as a biodiverse estuary of wetlands, meadows, and salt marsh islands. The purpose of this study is to analyze the water quality conditions of the region over time, comparing locations around the bay to identify hyperlocal features that influence larger trends in the hydrological system. Ten variables were used as water quality indicators, including total Kjeldahl nitrogen, salinity, pH, Secchi disk depth, and total phosphorus, among others, across five stations in the bay, between 1994 and 2024. After data cleaning and standardization methods were applied, principal component analysis …


Analyzing Harmony In Bulgarian And Bulgarian-Influenced Choral Arrangements From The Radio To The Screen, Annie Beliveau Sep 2026

Analyzing Harmony In Bulgarian And Bulgarian-Influenced Choral Arrangements From The Radio To The Screen, Annie Beliveau

Dissertations, Theses, and Capstone Projects

This dissertation investigates developments in arrangements and compositions made for Bulgarian choirs between 1950 and 2025. Arrangements from Bulgaria’s communist period (1944-1989), when musical radio broadcasts were tailored to promote nationalist sentiment, eventually reached the ears of foreigners on the other side of the Iron Curtain via recordings and ensemble tours. These obrabotki (arrangements of folk tunes) became popular in the “world music” boom of the 1980s, and foreign composers soon began to create new compositions for Bulgarian choirs to sing on albums and in scores for film, television, and video games. Over time, the uses of Bulgarian choir in …


Panopticism And Pan-Oticism: Sound-Power From Foucault To Deleuze, Eric Dillenberger Sep 2026

Panopticism And Pan-Oticism: Sound-Power From Foucault To Deleuze, Eric Dillenberger

Dissertations, Theses, and Capstone Projects

From Muzak to long range acoustic devices (LRADs), the contemporary proliferation of sonic technologies for governing moods, behaviors, and potentialities complicates the virtual absence of sound within Michel Foucault's primarily visual modality of disciplinary power in Discipline and Punish, exemplified by his central conceptual model of the panopticon. This thesis develops the corollary concept of pan-oticism to theorize the transformation of sound-power and its political function within administered sonic ecologies from Foucault's disciplinary societies to Gilles Deleuze's societies of control. Within the enclosed spaces constitutive of disciplinary societies, sound-power remains subordinated to Foucault's visual logic of panopticism, extending …


Investigating The Role Of Striatal Cholinergic Interneuron D2 Receptors In Behavioral Flexibility, Janyn J. Alfred Sep 2026

Investigating The Role Of Striatal Cholinergic Interneuron D2 Receptors In Behavioral Flexibility, Janyn J. Alfred

Dissertations, Theses, and Capstone Projects

Dopamine (DA) and acetylcholine (ACh) interact within the striatum to shape reward-based learning and choice behavior. DA D2 receptors on cholinergic interneurons (CIN D2Rs) were genetically knocked out to investigate their role in choice allocation using a two-lever matching paradigm. Behaviorally, both knockout (KO) and wild-type (WT) mice learned the initial task equally well. When shifted to asymmetric matching schedules (VI-90 vs. VI-180), ideal matching predicts that mice should allocate exactly 67% of their total responses to the rich lever. Neither group matched as predicted by the matching law. Instead, the KO mice showed a pattern where the higher rate …


Urban Counterpoint (1992–2003): The Piano Music Of Ed Bland, Joseph Vaz Sep 2026

Urban Counterpoint (1992–2003): The Piano Music Of Ed Bland, Joseph Vaz

Dissertations, Theses, and Capstone Projects

This dissertation analyzes the piano music of Ed Bland, a politically and philosophically vocal composer active in the second half of the twentieth century, whose music draws on both the European and American twentieth-century avant-garde, and on African American vernacular music genres from ragtime to hip-hop. A review of the historical and personal context for these pieces, and a detailed examination of the compositional processes used in this music, work together to demonstrate how Bland thought about the relationship between different musical genres and languages.

Through this combination of theory of musical genre, historical and biographical study, and detailed analysis …


Retrieval Information From Working Memory: The Output Gating Framework Perspective And Its Underlying Processes, Chen Tiferet-Dweck Sep 2026

Retrieval Information From Working Memory: The Output Gating Framework Perspective And Its Underlying Processes, Chen Tiferet-Dweck

Dissertations, Theses, and Capstone Projects

Working memory (WM) keeps information accessible and available for further processing. However, not all the information we maintain in WM is behaviorally relevant at any given moment. To act effectively, we must dynamically control which memory representations are accessed to support ongoing goal-directed behavior. While the mechanisms underlying the selection of single items from WM access are comparatively well-studied, less is known about the principles governing multi-item access. Existing models of WM access imply that selecting multiple items should take longer and be more error-prone than single-item access. Yet, paradoxically, prior studies have shown that retrieving all items in WM …


The Role Of Temperament In Criminal Trajectories: Development, Stability, And Predictive Power Across The Life Course, Joshua A. Lang Sep 2026

The Role Of Temperament In Criminal Trajectories: Development, Stability, And Predictive Power Across The Life Course, Joshua A. Lang

Dissertations, Theses, and Capstone Projects

Temperament, an individual's largely innate tendency to experience and regulate responses to their environment, has long been studied but was only recently introduced as a primary predictor of criminal behavior (DeLisi & Vaughn, 2014). While prior criminological theories have incorporated temperament-related constructs, such as negative affect (Agnew, 1992; Moffitt, 1993) and self-control (Gottfredson & Hirschi, 1990), no other theory has explicitly positioned temperament as the central factor in offending. DeLisi and Vaughn’s temperament-based theory of antisocial behavior posits that individuals with low effortful control and high negative emotionality—features of a difficult temperament—are more likely to engage in criminal behavior. Despite …


The Role Of External Factors In Shaping Carbohydrate Conformational Landscapes, Murat Yaman Sep 2026

The Role Of External Factors In Shaping Carbohydrate Conformational Landscapes, Murat Yaman

Dissertations, Theses, and Capstone Projects

Carbohydrates (glycans) are among the most structurally diverse biomolecules and participate in a wide range of biological processes, including molecular recognition, cell adhesion, immune response, host-pathogen interactions, and cellular signaling. Their biological functions are governed by a complex interplay between sequence, stereochemistry, conformational flexibility, and environmental factors. However, the structural heterogeneity and dynamic nature of glycans present significant challenges for both experimental characterization and theoretical modeling. In particular, the relationships between glycan structure, conformational dynamics, and the resulting potential energy surfaces remain incomplete.

This dissertation investigates how external factors modulate the potential energy surfaces of carbohydrates through a combination of …


‘A Sense Of The Sea’: Grassroots Culture, Care, And Endurance In Swansea, Cymru, Katy Clark Sep 2026

‘A Sense Of The Sea’: Grassroots Culture, Care, And Endurance In Swansea, Cymru, Katy Clark

Dissertations, Theses, and Capstone Projects

This thesis argues that under present conditions, everyday political-aesthetic life is not only about resistance or reproduction but about holding: the work of keeping people, practices, and attachment present and oriented as conditions change. Holding takes the form of care and maintenance; as practices of making, assembling, and imagining; and as the work that keeps open the possibility of renewed attachment to public things and to each other. In the field, this was named as ‘a sense of the sea’, an affective register characterized by wariness, attunement, attentiveness, orientation, and endurance. I am calling this a fragile infrastructure of …


Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric Sep 2026

Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric

Dissertations, Theses, and Capstone Projects

Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder with a lifetime prevalence of 5-6% in men, and 10-12% in women (National Center for PTSD). Generalized anxiety disorder (GAD) is a highly prevalent anxiety- and depression-related psychiatric disorder with a lifetime prevalence of 1-2% in men, and 3-4% in women (National Institutes of Health). Both of these disorders disproportionately affect women. A hallmark feature of both disorders is the maladaptive generalization of fear, in which defensive responses extend beyond the original traumatic or threatening stimulus to neutral or unrelated cues. This overgeneralization can become debilitating, disrupting cognitive, emotional, and …


New York City Women’S Experiences With Perinatal Depression Inquiries, Diagnosis, And Treatment Initiation, Caterina Pisciotta Sep 2026

New York City Women’S Experiences With Perinatal Depression Inquiries, Diagnosis, And Treatment Initiation, Caterina Pisciotta

Dissertations, Theses, and Capstone Projects

Perinatal depression represents a significant public health concern, yet many women who experience depression symptoms during the perinatal period (either during pregnancy and/or after birth) do not receive treatment. Initiatives, such as ThriveNYC, were designed to address these gaps by screening and treating perinatal women for maternal depression, integrating screening into routine perinatal care and strengthening pathways to treatment. Using representative survey data collected between 2016 and 2021 via the Center for Disease Control and Prevention’s Pregnancy Risk Assessment Monitoring System (PRAMS), this study examined trends in perinatal depression inquiries (a proxy for “screening”) and postpartum diagnosis, as well as …


Ultrafast Spectroscopy Of Organic Materials In Strong Light–Matter Interaction And Terahertz Optics, Kamyar Rashidi Sep 2026

Ultrafast Spectroscopy Of Organic Materials In Strong Light–Matter Interaction And Terahertz Optics, Kamyar Rashidi

Dissertations, Theses, and Capstone Projects

Ultrafast spectroscopy is a powerful tool for investigating phenomena that occur on extremely short timescales and for probing ultrabroadband spectral responses enabled by its ultrashort laser pulses. These capabilities are essential for advancing both the fundamental understanding of light–matter interactions and the development of next-generation optoelectronic technologies. The first part of this thesis investigates the ultrafast dynamics of organic exciton–polaritons and their application to controlling molecular excited-state processes using momentum-resolved pump–probe spectroscopy. A major challenge in these systems is the dark-state problem, where photoexcitation predominantly populates long-lived excitonic reservoir states that obscure the in trinsic dynamics of the hybrid light–matter …


Self-Organized Criticality In Biased Activated Random Walk, Joshua Meisel Sep 2026

Self-Organized Criticality In Biased Activated Random Walk, Joshua Meisel

Dissertations, Theses, and Capstone Projects

We demonstrate many of the conjectured universality and self-organized criticality (SOC) properties of the interacting particle system Activated Random Walk (ARW) in the setting of one-dimensional biased walks, as formulated for instance in Levine and Silvestri’s 2024 survey. Namely, there exists the same limiting critical state for two finite ARW models, as well as for the infinite model as the density approaches its critical value from below. Many of the desired properties hold, including heavy-tailed avalanches, but spatial correlations decay exponentially fast, a deviation from the SOC paradigm. Nonetheless, the obtained decay rate vanishes with the bias. Since the critical …


Latinos In Massachusetts: Salvadorans, Phillip Granberry, Florita Coto Tristán, Daniel Gascón Sep 2026

Latinos In Massachusetts: Salvadorans, Phillip Granberry, Florita Coto Tristán, Daniel Gascón

Gastón Institute Publications

As part of The Gastón Institute’s 2026 Latinos in Massachusetts series, we present here a profile of Salvadorans living in Massachusetts in 2024. This report analyzes Public Use Microdata Sample (PUMS) data from the 2024 American Community Survey (ACS), conducted by the U.S. Census Bureau. Our descriptive analysis uses both household- and individual-level data to estimate population size and percentages and to compare Salvadorans to Other Latinos and Non-Latinos in the state.


Parenthood And Re-Appraisal Of Childhood Maltreatment, Gayathri Cheran Sep 2026

Parenthood And Re-Appraisal Of Childhood Maltreatment, Gayathri Cheran

Dissertations, Theses, and Capstone Projects

Background: Child maltreatment is associated with poorer physical and mental health outcomes across the lifespan.  Individuals’ appraisals of childhood maltreatment have important implications for these outcomes.  Appraisal is shaped by biological, psychological, and social-cultural factors, each of which undergoes change in parenthood.  Parenthood may prompt re-appraisal of childhood maltreatment in that being a parent evokes one’s experience of being parented.

Hypotheses: (1) Re-appraisal will be more likely in parents than non-parents.  In parents, re-appraisal will be more likely among: (2) primiparous parents, (3) parents with offspring of the same sex, and (4) parents who experienced maltreatment older in childhood (at …


Architects Of Mrna Fate: Molecular And Cellular Control Of P-Body Organization In The Drosophilia Melanogaster Female Germline, Samantha Milano Sep 2026

Architects Of Mrna Fate: Molecular And Cellular Control Of P-Body Organization In The Drosophilia Melanogaster Female Germline, Samantha Milano

Dissertations, Theses, and Capstone Projects

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein condensates that regulate mRNA storage, translational repression, and decay. While the biochemical principles governing condensate assembly have been extensively studied in vitro, how P-body organization is established and dynamically regulated in vivo to control specific mRNA populations remains poorly understood. This dissertation investigated the molecular and cellular mechanisms that govern P-body architecture and function in the Drosophila melanogaster female germline. First, I identified the conserved LSm protein Trailer Hitch (Tral) as a central organizer of P-body architecture. Using quantitative confocal and super-resolution microscopy combined with chemical perturbations, I showed that Tral coordinates the …


New Cities, Old Names, Jason J. Palladino Sep 2026

New Cities, Old Names, Jason J. Palladino

Dissertations, Theses, and Capstone Projects

This thesis investigates instances of etymology-based wordplay of words from languages other than Latin and Greek in the Aeneid. There are instances of etymology-based wordplay (also known as etymological glosses) of multiple languages other than Greek and Latin. Books 1, 4, and 6 have etymological glosses of the Punic language, and Books 7, 9, and 12 have etymological glosses of various other languages of Italy, such as Oscan, Umbrian, and Etruscan. This thesis is divided into two sections that examine Punic etymological glosses and Italic etymological glosses, respectively. It aims to place Virgil’s use of non-Greek and Latin etymological wordplay …


Scrolling Through Stress: Physiological Stress Recovery Shapes Risk For Problematic Social Media Use In Young Adults With Depressive Symptoms, Abigail Findley Sep 2026

Scrolling Through Stress: Physiological Stress Recovery Shapes Risk For Problematic Social Media Use In Young Adults With Depressive Symptoms, Abigail Findley

Dissertations, Theses, and Capstone Projects

Depression is among the most consistent correlates of problematic social media use (PSMU), yet how depressive symptoms confer this risk, and for whom, remains poorly understood. The present study examined whether stress regulation explains the link between depressive symptoms and PSMU in young adults, testing specifically whether stress recovery acts as a mechanism linking the two or as a vulnerability that determines for whom they are linked, and whether distress tolerance (DT) shapes these pathways. Participants (N = 77) were young adults (18–25) with elevated depressive symptoms. Following the Trier Social Stress Test, participants completed a 15-minute social media …


Applications Of Entanglement In Quantum Information, Nada Ali Sep 2026

Applications Of Entanglement In Quantum Information, Nada Ali

Dissertations, Theses, and Capstone Projects

Entanglement is the resource that most sharply distinguishes quantum information processing from its classical counterpart, and this thesis examines it from two complementary directions: how it can be detected and quantified, and how it, together with the broader machinery of quantum correlations, interference, and measurement, can be put to use. We first study two simple, measurable conditions that detect bipartite entanglement, and show that the extent to which either is violated yields a lower bound on the negativity of a state. The bound is established for two qubits, extended to systems of arbitrary finite dimension, and sharpened when partial knowledge …


The Development And Piloting Of A Novel Client-Rated Trans And Gender Expansive Clinical Competence Scale For Mental Health Providers, Karen Abraham Sep 2026

The Development And Piloting Of A Novel Client-Rated Trans And Gender Expansive Clinical Competence Scale For Mental Health Providers, Karen Abraham

Dissertations, Theses, and Capstone Projects

Transgender and gender expansive individuals (TGEI) are people who encompass a broad and comprehensive set of experiences of gender diverse individuals and identities that exist both within and beyond a binary framework. In the United States, the Williams Institute identified a proportion of 0.5% of American adults identifying as transgender (Herman et al., 2022). TGE samples report poorer physical and mental health than their cisgender counterparts across the lifespan (Rastogi et al., 2025; Reisner et al., 2015; Reisner, Poteat, et al., 2016). Health disparities of TGEI relative to their non-TGE counterparts can be seen in the prevalence of mood disorders …


Performing Hybridity: Solo Cello Works By Diasporic Korean Composers Isang Yun And Younghi Pagh-Paan, Sarah Song Sep 2026

Performing Hybridity: Solo Cello Works By Diasporic Korean Composers Isang Yun And Younghi Pagh-Paan, Sarah Song

Dissertations, Theses, and Capstone Projects

This dissertation follows my personal exploration of solo cello works by Korean diasporic composers Isang Yun and Younghi Pagh-Paan. While the study of postwar Korean music has long been discussed within an “East meets West” framework, my research aims to abandon such divisive binaries and explores the activity between two musical cultures during learning and performance. By engaging with a wide network of meaning (e.g., score-based, extra-musical knowledge, historical context), I track cumulative layers of discovery while considering a multitude influences from Korean and Austro-Germanic cultures as a second-generation Korean American. My methodology includes a reflective approach categorized in two …


Object (Im)Permanence: Toward A Hauntology Of The Violin, Pala Garcia Sep 2026

Object (Im)Permanence: Toward A Hauntology Of The Violin, Pala Garcia

Dissertations, Theses, and Capstone Projects

Object (Im)permanence goes looking for the violin’s ontological uncertainties, its persistent historical specters, and its relation to things not fully present, no longer, or yet to come. Drawing on the history of the author’s own instrument as an inherited object, this study explores the violin’s strangest affordances: its capacity to hold a psychic charge, sustain absent presence, remotely activate somatic memory, and invite reciprocal relationality. Adapting the Derridean concept of “hauntology” as a framing for the violin’s spectral vitality, Object (Im)permanence imagines how a hauntology of the violin can account for its ontological uncertainties, logic of absent presence, and persistent …


Reimagining Folk Songs: A Bridge Between Tradition And Innovation In Georgy Sviridov’S Music, Polina Nazaykinskaya Sep 2026

Reimagining Folk Songs: A Bridge Between Tradition And Innovation In Georgy Sviridov’S Music, Polina Nazaykinskaya

Dissertations, Theses, and Capstone Projects

Georgy Sviridov (1915–1998), one of the most prominent Soviet composers of his generation, remains largely underrepresented in Western performance and scholarship. This dissertation examines the compositional language of Sviridov’s Kursk Songs (1964) through direct comparison with the seven folk songs published in Anna Rudneva’s 1957 collection Kurskie pesni that served as the work’s source material. The study addresses a central paradox of Sviridov’s musical language: how remarkably economical, predominantly diatonic materials can produce powerful and highly individual expressive results.

The analysis considers how Sviridov preserves essential characteristics of the folk sources while transforming their harmony, rhythm, form, texture, orchestration, and …


Skipping Town: An Examination Of Fugitive Travel Patterns, Flight Duration, And "Journey-From-Crime", Shun Q. Feng Sep 2026

Skipping Town: An Examination Of Fugitive Travel Patterns, Flight Duration, And "Journey-From-Crime", Shun Q. Feng

Dissertations, Theses, and Capstone Projects

Purpose: Existing research on fugitive mobility has largely examined fugitive travel patterns and flight duration as separate phenomena, often relying on limited geographic areas or a cross-section of the fugitive population. This dissertation addresses these gaps by examining where fugitives travel relative to their originating county, and how long they avoid apprehension. Utilizing a national sample of fugitives with data provided by the United States Marshals Service (USMS), the study investigates how individual characteristics, situational warrant factors, and county-level characteristics influence fugitive travel patterns across a broader, more comprehensive scope.

Methods: Using data from the Justice Detainee Information System (JDIS) …


Quaternionic Analogues Of Zagier’S Sums Of Binary Quadratic Forms, Ajmain A. Yamin Sep 2026

Quaternionic Analogues Of Zagier’S Sums Of Binary Quadratic Forms, Ajmain A. Yamin

Dissertations, Theses, and Capstone Projects

Let K be the real numbers R, complex numbers C or quaternions H. Let O ⊂ K be a full rank discrete Euclidean subring of K. We investigate certain functions F_{k,Δ,O} : K → R indexed by positive integers k, Δ with k odd. When K = R or C, these functions recover Zagier’s sums of binary quadratic forms and Karabulut’s sums of binary Hermitian forms respectively. When K = H, the F_{k,Δ,O} functions are new quaternionic analogues of Zagier's sums whose definition involves sums of binary Hamiltonian forms as defined by Parkkonen-Paulin.

We prove that for fixed "weight" k …


Outcomes For Congenitally Corrected Transposition Of Great Arteries Using Various Surgical Techniques: A Systematic Review And Network Meta-Analysis., S U Hasan, Sur Usmani, S H Ahmed, A Pervez, M A Kamalia, A D Shah, Mujeeb Zubair Sep 2026

Outcomes For Congenitally Corrected Transposition Of Great Arteries Using Various Surgical Techniques: A Systematic Review And Network Meta-Analysis., S U Hasan, Sur Usmani, S H Ahmed, A Pervez, M A Kamalia, A D Shah, Mujeeb Zubair

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Congenitally corrected transposition of the great arteries (ccTGA) is a rare disorder. Here, we evaluated the effectiveness of physiological, anatomical and Fontan repair techniques for ccTGA.

METHODS: A systematic database search in PubMed, Embase and Cochrane Central Register of Controlled Trials was conducted from inception to 5 June 2023. Random-effects network meta-analysis was performed, comparing mortality, postoperative arrhythmias, reintervention after definitive surgery and transplant-free survival in patients undergoing physiological, anatomical and Fontan repair.

FINDINGS: A total of 1,209 patients were included from nine studies. Fontan repair was associated with a higher rate of transplant-free survival (absolute risk [AR] 0.999 …


Perioperative Depression And Anxiety Care In Older Patients: A Randomized Clinical Trial, Joanna Abraham, Katherine J Holzer, Simon Haroutounian, Bethany Pennington, Ana Baumann, Ryan Calfee, Theresa Cordner, Kenneth E Freedland, Thomas Kannampallil, Benjamin Kozower, Emily Lenard, J Philip Miller, Mary Politi, Michael Yingling, Michael S Avidan, Eric J Lenze Sep 2026

Perioperative Depression And Anxiety Care In Older Patients: A Randomized Clinical Trial, Joanna Abraham, Katherine J Holzer, Simon Haroutounian, Bethany Pennington, Ana Baumann, Ryan Calfee, Theresa Cordner, Kenneth E Freedland, Thomas Kannampallil, Benjamin Kozower, Emily Lenard, J Philip Miller, Mary Politi, Michael Yingling, Michael S Avidan, Eric J Lenze

2020-Current year OA Pubs

IMPORTANCE: Depression and anxiety are common among older adults undergoing surgery and are associated with adverse postoperative outcomes. However, effective tailored perioperative mental health interventions are lacking.

OBJECTIVE: To evaluate a perioperative intervention to optimize mental health.

DESIGN, SETTING, AND PARTICIPANTS: A single-blind, hybrid, type 1, effectiveness-implementation randomized clinical trial was conducted (November 1, 2022, to March 31, 2025), with 3-month postoperative follow-up, at a US academic and community practice hospital network. Participants were 60 years or older; scheduled for cardiac, oncologic, or orthopedic surgery; and had clinically meaningful symptoms of depression and/or anxiety based on the Patient Health Questionnaire-Anxiety …