Digital Commons Network^™

Clinicopathological And Prognostic Significance Of Cxcr4 Expression In Osteosarcoma: A Meta-Analysis, I Gusti Ngurah Ananda Wira Kusuma, Grace Yulia Alphani Yapson, John Nolan, I Gede Eka Wiratnaya, I Gede Putu Supadmanaba

BioMedicine

Background: The C-X-C Motif Chemokine Receptor (CXCR4) is an oncogene that has been widely studied and associated with worse clinicopathological features and prognosis outcomes in many types of cancer. Besides that, significance of CXCR4 expression on clinicopathological features and prognostic factors in osteosarcoma (OS) requires further validation.

Aim: We conducted a meta-analysis to evaluate the association between positive CXCR4 expression with clinicopathological features and prognosis in OS.

Methods: Literature searches on Pubmed, Cochrane Library, and Web of Science were conducted systematically up to December 2021 to find relevant references. The effects of CXCR4 expression on clinicopathological characteristics and prognostic were …

View-Table Update Report, Rohini Ramesh

Defensive Publications Series

The present disclosure relates to a method and system for updating a view-table and generating a report for users. The present disclosure suggests updating details of a new column in the view table and comparing the updated column details with the metadata of a previous view-table. Further, the present disclosure suggests generating a view table report based on the comparison and notifying the view table report to the users. The generated view table report helps users in accessing updated view table data and maintaining a track of all the table updates.

Optimum Synthesis Of Au@Ag Nanoparticle As Plasma Amplifier To Detect Trace Concentration Of Afb1 Via Object-Binder-Metal Sers Method, Wenwen Chen, Qiang Chen, Wei Zhang, De Zhang, Zhi Yu, Ying Song, Xiubing Zhang, Dejiang Ni, Pei Liang

Journal of Food and Drug Analysis

The problem of aflatoxin contamination emerged gradually in the field of food safety. Surface-enhanced Raman spectroscopy (SERS) is an ultra-sensitive and non-destructive spectroscopy technology with extensive application prospects in the detection field. In this paper, with the detection of AFB1 as the target, Au@Ag NPs substrate with uniform morphology and strong SERS effect was prepared. Furthermore, the intermediates formed by hydrogen bonding between AFB1 and melamine facilitate the binding of toxin molecules to the substrate. Moreover, the AFB1-melamine-Au@Ag NPs detection system was established by optimizing the melamine dosage, and the limit of detection can reach 10^-8 mol/L (M). In …

The Effect Of Using Roundhouse Diagram Strategy In Achievement Of English Language For Tenth Grade Female Students' And Their Attitudes Toward It In Jordan, Siham Al-Mashaqbeh

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

This study aimed to identify The Effect of Using Roundhouse Diagram Strategy in Teaching the English language for Tenth Grade Female Students' and their Attitudes Toward it in Jordan. The participants Students were (40) from tenth grade. Female Students' from Umm Al-ma'am Secondary School, and they were distributed in to tow division.

The study was conducted in the second semester of the academic year 2018/2019, with (4) classes per week for each division. The study continued for (4) weeks, The semi-experimental method was used. The sample of the study was divided into two groups, one experimental and the other controlling …

The Reality Of The Application Of Modern Teaching Strategies In University Education At The University Of Amman From The Perspective Of The Members Of The Commission, Maha Khreisat, أسماء عبد المنعم العمري

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The present study aimed to identify the reality of the application of modern teaching strategies in university education at the Amman Private University in Jordan. The study sample consisted of (100) faculty members at Amman Private University in the academic year (2018/2017).The results of the study showed that the reality of the implementation of strategies in university education at the University of Amman was high, and the results showed that there was no effect of the variables of experience and faculty in the in the degree of application of teaching strategies. In light of the results of the study, the …

The Level Of Occupational Stress Among Public School Teachers In Jordan, Khalid Al-Mahasnieh

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The current study aimed to identify the level of occupational pressures that secondary school teachers are exposed to in Jerash Directorate of Education, and proposing some solutions to relieve such kind of pressures.

To achieve the objectives of the study, the researcher adopted the descriptive analytical method, both quantitative and qualitative, the study tool was a questionnaire contains (30) paragraphs, and an open question to suggest some possible solutions. The tool was applied to a sample of (274) secondary school teachers in Jerash Directorate of Education.

A set of suggestions were also presented, which it is hoped will work to …

The Reality Of Distance Education In Light Of The Corona Crisis On Students Of The First Three Basic Grades In Jordanian Public Schools From The Point Of View Of Their Teachers, Hanan Mashatelah

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The study aimed to reality the impact of distance education in light of the Corona crisis on students of the first three basic grades in Jordanian public schools from the point of view of their teachers. The researcher used the descriptive survey approach, and the tool was a questionnaire consisting of (40) items distributed into four areas that were distributed to a sample Random number of (250) teachers from all basic schools for the first three basic grades in Jordan amounting to (22150) teachers.

The results of the study showed that all areas of the questionnaire, as seen by teachers …

Transfer Of Administrative Experience In The Light Of The Corona Pandemic And Its Impact On The Quality Of Education In Public Schools In Ajloun Governorate From The Educational Supervisors Point Of View, Ghada Khatatbe

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The study aimed to identify the degree of transferring administrative expertise in light of the Corona pandemic and its impact on the quality of education in public schools in Ajloun Governorate from the Educational Supervisors Point of View. The study used the descriptive survey method. The sample consisted of (31) supervisors who were chosen by the survey method, the questionnaire was used as a tool for the study. The results of the study showed that the degree of the practice of transferring administrative expertise in light of the Corona pandemic in public schools in the Ajloun governorate from the educational …

The Differential Performance Of The Items Of The National Test To Control The Quality Of Education In The Subjects Of Science, Mathematics, Arabic And English For The Eighth Grade In Jordan, Mifleh Salman, Haider Thatha

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The current study aimed to detect the differential item functioning (DIF) of the items of the Jordanian National Test to control educational quality for the 8th grade in the government schools of Jordan according to gender, model of test presentation in 2019 using Generalized Mantel – Haenszel. The data of the study was available from the responses of the 8th grade students, totaling (10,000), to (158) test items in science, mathematics, Arabic and English subjects. The results showed that the mathematics subjects showed the highest percentage of (DIF) Where (77.5%) of them amounted to (17) items according to the model …

The Image-Argument In The Jordanian Media's Discourse On The Corona Pandemic: "Caricature Art Images As A Model", Mamoon Ananzeeh, Ahmad Mohammed Abu Dalu

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

This research aims to explore the elements of argument in caricature images in the Jordanian media discourse, and shows how the argument production of the caricature discourse is carried out. It concluded that the irony, that colors the caricature discourse, is a persuasive method full of connotations that summarize the social and economic situations of the Jordanian citizen in the Corona pandemic aiming to expose reality and criticize the government’s procedures, and reveal a set of socially unacceptable practices through a set of arguments and mechanisms that are mainly made by the irony

Disability As A Motif For Creativity: Philippe Croizon’S Experience In Theater And Cinema, Yassine Slimani

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

Disability is defined as a case of an emotional or physical deviation that hinders the individual from satisfying his natural needs in life due to the inability of performing the physiological or psychological tasks. Based on the social status-quo of the disabled, we notice that he is generally seen as a person who needs pity and is generally downgraded, bullied, and excluded. However, there are many disabled individuals who overcame this definition and vision and defied their disability circumstances and became creative in many domains. Their creativity became a real model even for non-disabled individuals such as Philippe Croizon who …

Solid Pseudopapillary Epithelial Neoplasm Of The Pancreas: A Case Report, Indu B. Dubey, Sajal Gupta, Shivani Paruthy, Vimal Bhandari

Journal of Medicine in Scientific Research

Solid pseudopapillary epithelial neoplasm (SPEN) of the pancreas is a rare neoplasm of the pancreas accounting for only 0.17–2.7% of all pancreatic neoplasms, often detected initially on imaging. Despite advances in imaging, pseudocysts and other cystic neoplasms feature in the differential diagnosis. We report a case of solid pseudopapillary epithelial neoplasm in a young female who presented with a progressively increasing abdominal lump in whom the diagnosis was considered based on imaging studies. She underwent exploratory laparotomy, pancreaticoduodenectomy, pancreaticojejunostomy, hepaticojejunostomy, gastrojejunostomy, and made an uneventful recovery in the postoperative period. Histopathological examination and immunohistochemistry confirmed the diagnosis. This case highlights …

Final Master's Portfolio, Anji Straayer

Master of Arts in English Plan II Graduate Projects

The following is a final portfolio for the Master's of English with a specialization in teaching. It is the culmination of my course of study and includes pieces reflective of the various courses I took and my various interests with literature and teaching. It opens with an analytical narrative overviewing my growth and learning at BGSU. The substantive research project is on multimodality and incorporating multimodal techniques into the secondary classroom. The second piece is a unit plan for the Greek play Antigone. The third and fourth pieces are literary analyses; one is a critique of the Victorian mindset as …

The Final Few Weeks, Falicity Fulton

2022-23 Postcards

Postcard from Felicity Fulton, during the Linfield University Semester Abroad Program, Fall 2022, at Aix en Provence in France.

Molecular Insights And Clinical Outcomes Of Drugs Of Abuse Adulteration: New Trends And New Psychoactive Substances, Annagiulia Di Trana, Diletta Berardinelli, Eva Montanari, Paolo Berretta, Giuseppe Basile, Marilyn A. Huestis, Francesco Paolo Busardò

Institute of Emerging Health Professions Faculty Papers

Adulteration is a well-known practice of drug manufacturers at different stages of drug production. The intentional addition of active ingredients to adulterate the primary drug may enhance or mask pharmacological effects or may produce more potent drugs to increase the number of available doses and the dealer's profit. Adulterants found in different drugs change over time in response to different factors. A systematic literature search in PubMed and Scopus databases and official international organizations' websites according to PRISMA guidelines was performed. A total of 724 studies were initially screened, with 145 articles from PubMed and 462 from Scopus excluded according …

Whispering Gallery Modes Of A Triatomic Photonic Molecule, Vladimir Shuvayev, Stanislav Kreps, Tal Carmon, Lev Deych

Publications and Research

In this paper, we present the results of numerical simulations of the optical spectra of a three-sphere photonic molecule. The configuration of the system was continuously modified from linear to triangular, in-plane with the fundamental mode excited in one of the spheres and perpendicular to it. We found the relative insensitivity of the spectra to the in-plane deviation from the linear arrangement up to about 110°. For larger angles, the spectra show significant modification consisting of the major spectral peaks splitting and shifting. On the contrary, the spectra are quite sensitive to out-of-plane molecule deviation, even at small angles. Thus, …

Methylone And Mdma Pharmacokinetics Following Controlled Administration In Humans, Lourdes Poyatos, Alfredo Fabrizio Lo Faro, Diletta Berardinelli, Giorgia Sprega, Sara Malaca, Simona Pichini, Marilyn A. Huestis, Esther Papaseit, Clara Pérez-Mañá, Francesco Paolo Busardò, Magí Farré

Institute of Emerging Health Professions Faculty Papers

The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50–200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone, MDMA, and their metabolites in plasma. The study was a randomized, cross-over, double-blinded and placebo-controlled study, with a total of 468 plasma samples collected. First, 10 µL of MDMA-d5, MDA-d5 and methylone-d3 internal standards were added to 100 µL of plasma. Two mL of chloroform and ethyl acetate 9:1 (v/v) were then added, mixed well and centrifuged. The supernatant was fortified with …

Transradial-Transfistula Access For Cardiac Catheterization In Patients With Abandoned Hemodialysis Fistulas, Noah Q. Haroian, Michael P. Savage, David L. Fischman

Department of Medicine Faculty Papers

Guidelines consider radial access a relative contraindication in patients with end-stage renal disease as part of a vessel preservation strategy. Radial access distal to a hemodialysis fistula, what we term transradial-transfistula access, offers a solution to radially access this population without affecting their vessel preservation plan. (Level of Difficulty: Advanced.)

December 1, 2022: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the December 1, 2022, meeting of the University Senate. 26 pages

Factors Influencing The Decision To Initiate Orthodontic Treatment And The Choice Of Appliance Type In A Lebanese Sample During The Covid-19 Pandemic And The Economic Crisis. A Cross-Sectional Study., Liliane Alameh, Elie Khoury, Elie Amm

International Arab Journal of Dentistry

Background: The spread of Coronavirus Disease 2019 (COVID-19) has led to a major public health issue. This study aimed to assess the factors that influence the Lebanese people in undergoing an orthodontic treatment after the outbreak of COVID-19, as well as the factors that influence their choice of orthodontic appliance type. Methods: 489 Lebanese participants (199 men and 290 women) were invited to fill a questionnaire developed on Google Forms. Eligible participants were simply Lebanese people including those who immigrated during the crisis. Dentists, dental students and foreigners were excluded from the study. The link for the questionnaire was sent …

Effects Of Substance Use Disorder On Oxidative And Antioxidative Stress Markers: A Systematic Review And Meta-Analysis, Thiago Wendt Viola, Rodrigo Orso, Luisa Fossati Florian, Miguel Gomes Garcia, Marco Giovanni Signor Gomes, Eduarda Mascarenhas Mardini, João Paulo Ottolia Niederauer, Aline Zaparte, Rodrigo Grassi-Oliveira

School of Medicine Faculty Publications

Recently, it has been suggested that central and peripheral toxicities identified in persons with substance use disorder (SUD) could be partially associated with an imbalance in reactive oxygen species and antioxidant defenses. We conducted a systematic review and meta-analysis to investigate whether SUD is associated with oxidative stress and to identify biomarkers possibly more affected by this condition. We have included studies that analysed oxidant and antioxidant markers in individuals with SUD caused by stimulants, alcohol, nicotine, opioids, and others (cannabis, inhalants, and polysubstance use). Our analysis showed that persons with SUD show higher oxidant markers and lower antioxidant markers …

The Effects Of Cross-Training On A Barrel Horse, Autumn Gallagher

Honors Theses

No abstract provided.

Epigenetic Regulation In Chromium-, Nickel- And Cadmium-Induced Carcinogenesis, Lei Zhao, Ranakul Islam, Yifang Wang, Xiujuan Zhang, Ling-Zhi Liu

Department of Medical Oncology Faculty Papers

Environmental and occupational exposure to heavy metals, such as hexavalent chromium, nickel, and cadmium, are major health concerns worldwide. Some heavy metals are well-documented human carcinogens. Multiple mechanisms, including DNA damage, dysregulated gene expression, and aberrant cancer-related signaling, have been shown to contribute to metal-induced carcinogenesis. However, the molecular mechanisms accounting for heavy metal-induced carcinogenesis and angiogenesis are still not fully understood. In recent years, an increasing number of studies have indicated that in addition to genotoxicity and genetic mutations, epigenetic mechanisms play critical roles in metal-induced cancers. Epigenetics refers to the reversible modification of genomes without changing DNA sequences; …

Qualitative Analysis Of A Twitter-Disseminated Survey Reveals New Patient Perspectives On The Impact Of Urinary Tract Infection, Marissa Valentine-King, Lindsey Laytner, Casey Hines-Munson, Kiara Olmeda, Barbara Trautner, Sheryl Justice, Christina Ching, Larissa Grigoryan

Faculty, Staff and Students Publications

Few studies have harnessed social media to explore patients’ experiences with urinary tract infection (UTI); therefore, we captured UTI experiences and future research suggestions through a Twitter-disseminated survey. The survey posed three qualitative questions inquiring about the impact of UTIs, greatest UTI management hurdle, and research suggestions. We also asked participants to rate how seriously others perceive UTIs and the importance of UTIs in their life (scale: 1–100 (highest)). The study period spanned from January to June 2021. Coding was performed in duplicate, followed by thematic analysis. Of 466 participants from 22 countries, 128 considered their UTIs recurrent (n …

What Multi-Disciplinary Delivery Models For Occupational Health Services Are Effective For Whom? An Umbrella Review, Elizabeth Shaw, M Nunns, Stuart Spicer, Hassanat Lawal, G. J. Melendez-Torres, Ruth Garside, Kristin Liabo, J Thompson-Coon

Peninsula Medical School

No abstract provided.

Predictions Of Household Water Affordability Under Conditions Of Climate Change, Demographic Growth, And Fresh Groundwater Depletion In A Southwest Us City Indicate Increasing Burdens On The Poor, Josiah M. Heyman, Alex S. Mayer, Jessica Alger

Michigan Tech Publications, Part 1

Reduced river flows and groundwater depletion as a result of climate change and population growth have increased the effort and difficulty accessing and processing water. In turn, residential water costs from municipal utilities are predicted to rise to unaffordable rates for poor residential water customers. Building on a regional conjunctive use model with future climate scenarios and 50-year future water supply plans, our study communicates the effects of climate change on poor people in El Paso, Texas, as water becomes more difficult and expensive to obtain in future years. Four scenarios for future water supply and future water costs were …

The Glycemic, Cholesterol, And Weight Effects Of L-Carnitine In Diabetes: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Jennifer Ko, Eva Y. Wong, Huyentran N. Tran, Rebecca J.C. Tran, Diana X. Cao

Pharmacy Faculty Articles and Research

Introduction

L-carnitine possibly impacts insulin sensitivity and glucose metabolism. However, its therapeutic role in diabetes is poorly understood.

Methods

A systematic review and meta-analysis were conducted using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception through June 30, 2021. Included studies evaluated the use of L-carnitine in diabetes on fasting blood glucose (FBG), hemoglobin A1c (HbA1c), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), weight, or body mass index (BMI). Weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated using the DerSimonian and Laird random-effects model.

Results

Seventeen studies …

Temporal Regulation Of Notch Activation Improves Arteriovenous Fistula Maturation, Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang, Jizhong Cheng

Faculty, Staff and Students Publications

Background: Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally controlled Notch activation to promote AVF maturation while avoiding neointima formation.

Methods: Temporal Notch activation was controlled by regulating the expression of Notch transcription factor, RBP-Jκ, or dnMAML1 (dominant negative MAML2) in vascular smooth muscle cells (VSMCs). AVF mouse model was created and VSMC phenotype dynamic changes during AVF remodeling were determined.

Results: Activated Notch was found in the nuclei of neointimal VSMCs in AVFs from uremic …

Commodity Fetishism And The Crisis Of Contemporary Art, E. San Juan Jr.

Mabini Review

Special Feature Article

Muslim-Christian Goodness Of Life As A Philosophical Perspective, Fr. Jaime Del Rosario

Mabini Review

Being Filipinos delving into philosophical discussions necessitates expanding the majority Christian viewpoint that crosses religious affiliation into the Muslim viewpoint as well. In Mindanao, particularly where Filipinos are a blending of Muslims, Christians, various Indigenous People’s communities, and mestizos of genetic and/or cultural hybridity of human identification even extend to various others for further consideration while in the paper the focus is on Muslim-Christian understanding of the notion of goodness of life. Philosophizing in this locality can expand the horizon of Filipinos who philosophize outside of Mindanao. A philosophical perspective needs to understand the ongoing blending of the Muslim and …