Digital Commons Network^™

Impact Of Dietary Walnuts, A Nutraceutical Option, On Circulating Markers Of Metabolic Dysregulation In A Rodent Cachectic Tumor Model, Lauri O. Byerley, Hsiao Man Chang, Brittany Lorenzen, Jessie Guidry, W. Elaine Hardman

School of Medicine Faculty Publications

Background: Nutraceutical foods, like walnuts which are rich in immunonutrients, can have medicinal benefits. Dietary walnuts have been shown to slow or prevent tumor growth in mice genetically programmed to grow breast or prostate tumors. This study investigated whether walnuts could exert the same preventable effect in a transplantable carcinoma rat model. Methods: Eighteen rats were randomly fed a diet containing walnuts (10% of food by weight), and 36 were fed a diet without walnuts (control) for 21 days. On day 22, 18 control diet rats were switched to the walnut diet. All other animals remained on their same diet. …

Politically Speaking: Ethnic Language And Audience Opinion In Southeast Asia, Jacob I. Ricks

Research Collection School of Social Sciences

Language is one of the quintessential markers of ethnicity. It allows co-ethnics to easily identify one another and underscores in-group and out-group boundaries. Recognizing this, politicians frequently employ ethnic tongues to enhance their political appeal. To what extent does this shape the opinions of their audiences? Utilizing a survey experiment, I test the impact of an ethnic tongue against that of the common political language among the Javanese in Indonesia, the Tagalog in the Philippines, and the Isan people in Thailand. The experiment demonstrates that the ethnic language has a significant impact in both Thailand and Indonesia, but there appears …

Epic-Kitchens Visor Benchmark: Video Segmentations And Object Relations, Ahmad Ak Dar Khalil, Dandan Shan, Bin Zhu, Jian Ma, Amlan Kar, Richard Higgins, David Fouhey, Sanja Fidler, Dima Damen

Research Collection School Of Computing and Information Systems

We introduce VISOR, a new dataset of pixel annotations and a benchmark suite for segmenting hands and active objects in egocentric video. VISOR annotates videos from EPIC-KITCHENS, which comes with a new set of challenges not encountered in current video segmentation datasets. Specifically, we need to ensure both short- and long-term consistency of pixel-level annotations as objects undergo transformative interactions, e.g. an onion is peeled, diced and cooked - where we aim to obtain accurate pixel-level annotations of the peel, onion pieces, chopping board, knife, pan, as well as the acting hands. VISOR introduces an annotation pipeline, AI-powered in parts, …

Vfirm: Verifiable Fine-Grained Encrypted Image Retrieval In Multi-Owner Multi-User Settings, Qiuyun Tong, Yinbin Miao, Lei Chen, Jian Weng, Kim-Kwang Raymond Choo, Ximeng Liu, Robert H. Deng

Research Collection School Of Computing and Information Systems

To ensure the security of images outsourced to the malicious cloud without affecting searchability on such outsourced (typically encrypted) images, one could use privacy-preserving Content-Based Image Retrieval (CBIR) primitive. However, conventional privacy-preserving CBIR schemes based on Searchable Symmetric Encryption (SSE) are not capable of supporting efficient fine-grained access control and result verification simultaneously. Therefore, in this article, we propose a Verifiable Fine-grained encrypted Image Retrieval scheme in the Multi-owner multi-user settings (VFIRM). VFIRM first utilizes a novel polynomial-based access strategy to provide efficient fine-grained access control. Then, it employs the dual secure kk-nearest neighbor technique to distribute distinct keys to …

Untouchable Once Revoking: A Practical And Secure Dynamic Ehr Sharing System Via Cloud, Shengmin Xu, Jianting Ning, Xinyi Huang, Yingjiu Li, Guowen Xu

Research Collection School Of Computing and Information Systems

Healthcare Internet-of-Things (IoT) enables lightweight devices to observe patients’ vital signals and outsource them to a remote cloud to enjoy flexible data sharing. However, it faces many security threats as the outsourced data is no longer physically controlled by data owners, and the cloud that hosts the outsourced data is not fully trusted. Many privacy protection technologies have been adopted to solve this problem, among which cryptographic mechanisms have become one of the most promising tools. Unfortunately, current cryptographic mechanisms in healthcare IoT mainly suffer from the following challenges: 1) dynamic user groups for managing users’ accessibility; 2) efficient revocation …

Reliable Policy Updating Under Efficient Policy Hidden Fine-Grained Access Control Framework For Cloud Data Sharing, Zuobin Ying, Wenjie Jiang, Ximeng Liu, Shengmin Xu, Robert H. Deng

Research Collection School Of Computing and Information Systems

Ciphertext-Policy Attribute-Based Encryption (CP-ABE) is one of the potent encryption paradigms in protecting data confidentiality in the cloud data sharing scenario. However, the access policy of the traditional CP-ABE is in plaintext form that reveals significant sensitive information of data owners and data visitors. To mitigate this problem, two approaches have been proposed in the literature. One is partially hidden, where the attributes in the access policy are divided into two parts: the plaintext attribute names and the hidden attribute values. The other approach fully hides the attributes in the access policy which, unfortunately, hinders efficient and correct decryption as …

Improving Experience Of Medical Abortion At Home In A Changing Therapeutic, Technological And Regulatory Landscape: A Realist Review, P Baraitser, C Free, Wv Norman, M Lewandowska, R Meiksin, Mj Palmer, R Scott, R French, K Wellings, A Ivory, G Wong

More Faculty of Health Research

Objective. To inform UK service development to support medical abortion at home, appropriate for person and context. Design. Realist review Setting/participants Peer-reviewed literature from 1 January 2000 to 9 December 2021, describing interventions or models of home abortion care. Participants included people seeking or having had an abortion. Interventions. Interventions and new models of abortion care relevant to the UK. Outcome measures. Causal explanations, in the form of context-mechanism-outcome configurations, to test and develop our realist programme theory. Results. We identified 12 401 abstracts, selecting 944 for full text assessment. Our final review included 50 papers. Medical abortion at home …

Are Training And Experience Adapting Evidence-Based Interventions Associated With Self-Efficacy And Attitudes? A Cross-Sectional Survey Of Students And Practitioners With Varying Levels Of Adaptation Experience, Cam Escoffery, Maya Foster, María E Fernández, Regine Haardörfer, Patricia Dolan Mullen

Faculty, Staff and Student Publications

Increasing use of evidence-based interventions (EBIs) in local settings will help reduce the research-practice gap and improve health equity. Because adaptation to new settings and populations is essential to effective EBI use, frameworks to guide practice are receiving more attention; most, however, only provide broad guidelines without instructions for making adaptations in practice. Therefore, practitioners may need additional training or technical assistance (TA) to implement and adapt EBIs. This study explores whether practitioners' and students' general EBI training or TA and level of adaptation experience are associated with self-efficacy in adapting EBIs and with attitudes toward EBI use. We analyzed …

Prevalent Multimorbidity Combinations Among Middle-Aged And Older Adults Seen In Community Health Centers, Ana R Quiñones, Steele H Valenzuela, Nathalie Huguet, Maria Ukhanova, Miguel Marino, Jennifer A Lucas, Jean O'Malley, Teresa D Schmidt, Robert Voss, Katherine Peak, Nathaniel T Warren, John Heintzman

Faculty, Staff and Student Publications

BACKGROUND: Multimorbidity (≥ 2 chronic diseases) is associated with greater disability and higher treatment burden, as well as difficulty coordinating self-management tasks for adults with complex multimorbidity patterns. Comparatively little work has focused on assessing multimorbidity patterns among patients seeking care in community health centers (CHCs).

OBJECTIVE: To identify and characterize prevalent multimorbidity patterns in a multi-state network of CHCs over a 5-year period.

DESIGN: A cohort study of the 2014-2019 ADVANCE multi-state CHC clinical data network. We identified the most prevalent multimorbidity combination patterns and assessed the frequency of patterns throughout a 5-year period as well as the demographic …

Tdap-Hpv Vaccination Bundling In The Usa: Trends, Predictors, And Implications For Vaccine Series Completion, Yenan Zhu, Chi-Fang Wu, Anna R Giuliano, Maria E Fernandez, Ana P Ortiz, Cecilia Ganduglia Cazaban, Ruosha Li, Ashish A Deshmukh, Kalyani Sonawane

Faculty, Staff and Student Publications

The Centers for Disease Control and Prevention (CDC) promotes taking a 'bundling approach' (i.e., administering Tetanus, diphtheria toxoids, and acellular pertussis [Tdap] and human papillomavirus [HPV] vaccines in the same way and on the same day) for adolescent vaccinations. Recent trends and patterns in Tdap-HPV vaccination bundling in the USA remain undocumented. In addition, the implications of bundling Tdap-HPV vaccination for HPV vaccine series completion remain unknown. to address these critical knowledge gaps, we performed a retrospective study using a nationwide sample of privately insured adolescents (Optum's de-identified Clinformatics® Data Mart Database). Tdap-HPV vaccination bundling (per 100 Tdap vaccination encounters) …

Assessing Predictive Discrimination Performance Of Biomarkers In The Presence Of Treatment-Induced Dependent Censoring, Cuihong Zhang, Jing Ning, Steven H Belle, Robert H Squires, Jianwen Cai, Ruosha Li

Faculty, Staff and Student Publications

In medical studies, some therapeutic decisions could lead to dependent censoring for the survival outcome of interest. This is exemplified by a study of paediatric acute liver failure, where death was subject to dependent censoring due to liver transplantation. Existing methods for assessing the predictive performance of biomarkers often pose the independent censoring assumption and are thus not applicable. In this work, we propose to tackle the dependence between the failure event and dependent censoring event using auxiliary information in multiple longitudinal risk factors. We propose estimators of sensitivity, specificity and area under curve, to discern the predictive power of …

Assessing Urinary Phenol And Paraben Mixtures In Pregnant Women With And Without Gestational Diabetes Mellitus: A Case-Control Study, Wei-Jen Chen, Candace Robledo, Erin M Davis, Jean R Goodman, Chao Xu, Jooyeon Hwang, Amanda E Janitz, Tabitha Garwe, Antonia M Calafat, Jennifer D Peck

Faculty, Staff and Student Publications

Prior studies have identified the associations between environmental phenol and paraben exposures and increased risk of gestational diabetes mellitus (GDM), but no study addressed these exposures as mixtures. As methods have emerged to better assess exposures to multiple chemicals, our study aimed to apply Bayesian kernel machine regression (BKMR) to evaluate the association between phenol and paraben mixtures and GDM. This study included 64 GDM cases and 237 obstetric patient controls from the University of Oklahoma Medical Center. Mid-pregnancy spot urine samples were collected to quantify concentrations of bisphenol A (BPA), benzophenone-3, triclosan, 2,4-dichlorophenol, 2,5-dichlorophenol, butylparaben, methylparaben, and propylparaben. Multivariable …

Does Hospital Location Matter? Association Of Neighborhood Socioeconomic Disadvantage With Hospital Quality In Us Metropolitan Settings, Nwabunie Nwana, Wenyaw Chan, James Langabeer, Bita Kash, Trudy Millard Krause

Faculty, Staff and Student Publications

An aspect of a hospital's location, such as its degree of socioeconomic disadvantage, could potentially affect quality ratings of the hospital; yet, few studies have granularly explored this relationship in United States (US) metropolitan areas characterized by a wide breadth of socioeconomic disparities across neighborhoods. An understanding of the effect of neighborhood socioeconomic disadvantage on hospital quality of care is informative for targeting resources in poor neighborhoods. We assessed the association of neighborhood socioeconomic disadvantage with hospital quality of care across several areas of quality (including mortality, readmission, safety, patient experience, effectiveness of care, summary and overall star rating) in …

Clinical Significance And Potential Role Of Trimethylamine N-Oxide In Neurological And Neuropsychiatric Disorders, Sowjanya Mudimela, Narahari Koppa Vishwanath, Anilkumar Pillai, Rodrigo Morales, Sean P Marrelli, Tatiana Barichello, Vijayasree V Giridharan

Faculty, Staff and Student Publications

Research in the last three decades has attracted the attention of many scientists and industrialists on the gut microbiome and its metabolites. Among many of these metabolites, trimethylamine oxide. Dietary choline, phosphatidylcholine, carnitine, and betaine produces TMAO that with other gut metabolites such as TMA (trimethylamine), and short-chain fatty acids (SCFA) enter the circulation. Finally they reach the brain through the blood-brain barrier (BBB) where they are involved in several physiological functions such as brain development, neurogenesis, and behavior. Gut-microbiota composition is influenced by diet, lifestyle, antibiotics, and age resulting in dysbiosis. Several studies have confirmed that altered TMAO levels …

Why Do The Police Reject Counseling? An Examination Of Necessary Changes To Police Subculture. Necessary Changes To Police Subculture., Noel Otu, Ntiense E. Otu

Criminal Justice Faculty Publications

This paper reviews the concept of police subculture and examines its role in the management and acceptance of treatment for stress-related injury. In particular, we examine the impact of stigma that attaches to treatment within this subculture. The persistence of the dominant police subculture remains a significant obstacle to officers seeking treatment for stress-related illnesses. The subculture has historically resisted acknowledging the need for treatment in response to the occupational and/or organizational stress-related injury that results from frequent exposure to work-related trauma. Many police administrators are still embedded within and resist changes to the subculture, which results in an atmosphere …

Interpreting State Statutes In Federal Court, Aaron-Andrew P. Bruhl

Faculty Publications

This Article addresses a problem that potentially arises whenever a federal court encounters a state statute. When interpreting the state statute, should the federal court use the state’s methods of statutory interpretation—the state’s canons of construction, its rules about the use of legislative history, and the like—or should the court instead use federal methods of statutory interpretation? The question is interesting as a matter of theory, and it is practically significant because different jurisdictions have somewhat different interpretive approaches. In addressing itself to this problem, the Article makes two contributions. First, it shows, as a normative matter, that federal courts …

Asking The Right Questions To Solve Algebraic Word Problems, Ege Yi̇ği̇t Çeli̇k, Zeynel Orulluoğlu, Ridvan Mertoğlu, Selma Teki̇r

Turkish Journal of Electrical Engineering and Computer Sciences

Word algebra problems are among challenging AI tasks as they combine natural language understanding with a formal equation system. Traditional approaches to the problem work with equation templates and frame the task as a template selection and number assignment to the selected template. The recent deep learning-based solutions exploit contextual language models like BERT and encode the natural language text to decode the corresponding equation system. The proposed approach is similar to the template-based methods as it works with a template and fills in the number slots. Nevertheless, it has contextual understanding because it adopts a question generation and answering …

Improving (And Avoiding) Interstate Interpretive Encounters, Aaron-Andrew P. Bruhl

Faculty Publications

State courts often encounter the statutes of other states. Any encounter with another state’s statutes raises an interesting but inconspicuous question about choice of law. In particular, the interstate encounter presents a choice of interpretive law. Despite some universal practices in statutory interpretation, there are methodological differences across jurisdictions—both at the level of overall approach and in the details of particular interpretive canons. When a state court encounters the statute of a sister state, may the forum state use its own interpretive methods or must it instead use the methods of the enacting state?

The existing doctrine on this choice-of-law …

Home E-Cigarette Rules And Youth's Vulnerability To Initiate And Sustain E-Cigarette Use, Anne Buu, Joon Kyung Nam, Meng Yang, Wei-Chung Su, Hsien-Chang Lin

Faculty, Staff and Student Publications

Existing studies of the impact of home rules on youth's vulnerability to e-cigarette use were based on cross-sectional data, youth or parent reports alone, as well as youth's perceptions and susceptibility. This study capitalizes on the restricted-use data of the Population Assessment of tobacco and Health (PATH) Study to examine the longitudinal association between home rules for e-cigarette use and youth's vulnerability including initiation of use and regular use two years later. Secondary analysis was conducted on 1203 parent-youth pairs who participated in both Wave 4 (2016-2018) and Wave 5 (2018-2019) assessment of the PATH Study and while the youth …

Good Newsletter November 1, 2022, Seattle University School Of Law Dean

GOOD NEWSletter

No abstract provided.

Primary Failure Of Tooth Eruption: Etiology And Management, Tetsutaro Yamaguchi, Kazuyoshi Hosomichi, Tatsuo Shirota, Yoichi Miyamoto, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

Primary failure of eruption (PFE) is a rare disorder defined as incomplete tooth eruption despite the presence of a clear eruption pathway. PFE is known to be caused by rare variants in the parathyroid hormone 1 receptor gene (PTH1R). Although several PTH1R variants have been reported, the etiology of PFE remains unclear. However, important studies that help elucidate the pathology of PFE have recently been published. The purpose of this review is to summarize current treatment options, clinical symptoms or phenotypes for diagnosis, genetic information including solid evidence in mouse disease models and disease-specific induced pluripotent stem cells, …

Association Of Social Needs And Healthcare Utilization Among Medicare And Medicaid Beneficiaries In The Accountable Health Communities Model, Jennifer Holcomb, Linda Highfield, Gayla M Ferguson, Robert O Morgan

Faculty, Staff and Student Publications

BACKGROUND: Integration of health-related social needs (HRSNs) data into clinical care is recognized as a driver for improving healthcare. However, few published studies on HRSNs and their impact are available. CMS sought to fill this gap through the Accountable Health Communities (AHC) Model, a national RCT of HRSN screening, referral, and navigation. Data from the AHC Model could significantly advance the field of HRSN screening and intervention in the USA.

OBJECTIVE: to present data from the Greater Houston AHC (GH-AHC) Model site on HRSN frequency and the association between HRSNs, sociodemographic factors, and self-reported ED utilization using a cross-sectional design. …

Using Audience Segmentation Approaches To Inform Integrated Family Planning And Maternal Health Programs In Niger, Breakthrough Research

Sexual and Reproductive Health, Rights, and Choices

Understanding the specific behavioral determinants and barriers to health-seeking for reproductive and maternal health services is critical to developing social and behavior change (SBC) programs that can best address the needs of the community. Effective SBC interventions can incorporate audience segmentation, the practice of dividing an audience into subgroups based on demographic, psychographic, and/or behavioral factors to develop tailored SBC approaches that are most likely to resonate with each audience subgroup. This brief presents study results of audience profiles for women of reproductive age in Niger with a focus on three reproductive and maternal health behaviors. It is intended to …

Rare Genetic Variants Explain Missing Heritability In Smoking, Seon-Kyeong Jang, Luke Evans, Allison Fialkowski, Donna K Arnett, Allison E Ashley-Koch, Kathleen C Barnes, Diane M Becker, Joshua C Bis, John Blangero, Eugene R Bleecker, Meher Preethi Boorgula, Donald W Bowden, Jennifer A Brody, Brian E Cade, Brenda W Campbell Jenkins, April P Carson, Sameer Chavan, L Adrienne Cupples, Brian Custer, Scott M Damrauer, Sean P David, Mariza De Andrade, Carla L Dinardo, Tasha E Fingerlin, Myriam Fornage, Barry I Freedman, Melanie E Garrett, Sina A Gharib, David C Glahn, Jeffrey Haessler, Susan R Heckbert, John E Hokanson, Lifang Hou, Shih-Jen Hwang, Matthew C Hyman, Renae Judy, Anne E Justice, Robert C Kaplan, Sharon L R Kardia, Shannon Kelly, Wonji Kim, Charles Kooperberg, Daniel Levy, Donald M Lloyd-Jones, Ruth J F Loos, Ani W Manichaikul, Mark T Gladwin, Lisa Warsinger Martin, Mehdi Nouraie, Olle Melander, Deborah A Meyers, Courtney G Montgomery, Kari E North, Elizabeth C Oelsner, Nicholette D Palmer, Marinelle Payton, Anna L Peljto, Patricia A Peyser, Michael Preuss, Bruce M Psaty, Dandi Qiao, Daniel J Rader, Nicholas Rafaels, Susan Redline, Robert M Reed, Alexander P Reiner, Stephen S Rich, Jerome I Rotter, David A Schwartz, Aladdin H Shadyab, Edwin K Silverman, Nicholas L Smith, J Gustav Smith, Albert V Smith, Jennifer A Smith, Weihong Tang, Kent D Taylor, Marilyn J Telen, Ramachandran S Vasan, Victor R Gordeuk, Zhe Wang, Kerri L Wiggins, Lisa R Yanek, Ivana V Yang, Kendra A Young, Kristin L Young, Yingze Zhang, Dajiang J Liu, Matthew C Keller, Scott Vrieze

Faculty, Staff and Student Publications

Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability ([Formula: see text]) was estimated from 0.13 to 0.28 (s.e., 0.10-0.13) in European ancestries, with 35-74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5-4 times higher than past …

The Association Between Egocentric Sexual Networks And Sexual Meeting Venues With Prep Conversation And Encouragement For Use Among Latinx Men Who Have Sex With Men, Mariano Kanamori, Cho-Hee Shrader, Juan Flores-Arroyo, Ariana Johnson, Edda Rodriguez, Stephen Fallon, John Skvoretz, Victor Gonzalez, Susanne Doblecki-Lewis, Adam Carrico, Kayo Fujimoto, Mark Williams, Steven Safren

Faculty, Staff and Student Publications

Despite the increasing availability of pre-exposure prophylaxis (PrEP), Latinx men who have sex with men (LMSM) are not receiving PrEP-related information. To understand the influence of LMSM sexual networks on PrEP-related conversations and encouragement to use PrEP, this cross-sectional egocentric network study characterized the PrEP-related communication of 130 LMSM egos with 507 sexual partners (alters). Participants were recruited using respondent-driven sampling methods from a Miami-Dade County community-health organization. Egocentric-level data were collected from 2018-2019 and analyzed using multilevel modeling. Of egos, 30% reported using PrEP. Closeness between participants and sexual partners played a role in PrEP conversation and encouragement. Participants …

The Influence Of Language On Thematic Apperception Test Assessment Of Defenses In International Spanish-Speaking College Students, Ilenia Perez-Palen

Theses and Dissertations

Cultural influences, including the use of language, have been shown to affect personality development and are also likely to impact personality assessment results. The influence of language is particularly relevant in story-telling measures such as the Thematic Apperception Test (TAT; Morgan & Murray, 1935). The purpose of this study was to analyze TAT narratives delivered in English and Spanish to assess the application of defense mechanisms based on the Defense Mechanism Manual (DMM; Cramer, 1991) among Hispanic international students. No study to date has provided insight into Hispanic individuals’ use of language with the TAT, specifically on scores for the …

Risk For Preeclampsia Associated With Nutritional Deficiencies And Modified By Apol1 Genotype, Winter S. Bruner

Theses and Dissertations (ETD)

Preeclampsia (PE) is a hypertensive disorder of pregnancy that is associated with micronutrient deficiencies. Nutrients involved in placental health and maintenance, such as vitamin D and folate, are important nutrients to assess in the risk of PE. As gestational age increases, the levels of vitamin D and folate potentially have incrementally increasing concentrations associated with PE. In addition to micronutrient deficiencies, PE is also associated with the presence of APOL1 high-risk (HR) variants. It was also hypothesized that a potential additive effect exists between HR APOL1 genotype status and nutritional deficiencies that would place individuals at a higher risk of …

Period, Break, Form, David Sergeant

School of Law, Humanities and Social Sciences

This essay examines the relationship between novelistic form and a historical moment shaped by new technologies in Dave Eggers's The Circle (2013) and Kim Stanley Robinson's Red Moon (2018). In both, the novel form is itself positioned as a major counterforce against the malignant powers that are attempting to form the age. Also in both, new technologies are understood not as primary or independent shaping forces but as enabling components of a larger political and economic form, a variant of capitalism. However, the crucial difference between the two novels is in how they periodize this capitalism, an act that is …

Do Time-Compressed General Education Courses Increase Course And Semester Retention Rates?, Michael Lee Dixon

Electronic Theses and Dissertations

Access to higher education remains a fundamental principle of the community college mission. Community colleges provide a critical starting point for many traditional and nontraditional students who enter higher education. Yet, in recent years, community colleges have endured public criticism for low graduation rates and the extended time students take to graduate. Many community colleges adapted long-held practices by implementing student success initiatives, including offering time-compressed courses to address concerns. The purpose of this study was to examine the effects of time-compressed courses on course retention rates and fall-to-spring semester retention rates of students. Quantitative methods were used to compare …

Effects Of Escalating Temporary Mechanical Circulatory Support In Patients With Worsening Cardiogenic Shock, Iyad N Isseh, Sarah Gorgis, Carina Dagher, Shivani Sharma, Mir B Basir, Sachin Parikh

The Texas Heart Institute Journal

BACKGROUND: Cardiogenic shock-related mortality is substantial, and temporary mechanical circulatory support (MCS) devices are frequently used. The authors aimed to describe patient characteristics and outcomes in patients with worsening cardiogenic shock requiring escalation of temporary MCS devices.

METHODS: Worsening cardiogenic shock was defined as persistent hypotension, increasing doses of vasopressors/inotropes, worsening hypoperfusion, or worsening invasive hemo-dynamics. Escalation of temporary MCS devices was defined as adding or exchanging an existing MCS device. Variables were evaluated by logistic regression models and receiver operating characteristic curves.

RESULTS: From July 1, 2016, to July 1, 2018, a total of 81 consecutive patients experienced worsening …