Digital Commons Network^™

Assessing Urinary Phenol And Paraben Mixtures In Pregnant Women With And Without Gestational Diabetes Mellitus: A Case-Control Study, Wei-Jen Chen, Candace Robledo, Erin M. Davis, Jean R. Goodman, Chao Xu, Jooyeon Hwang, Amanda E. Janitz, Tabitha Garwe, Antonia M. Calafat, Jennifer D. Peck

School of Medicine Publications

Prior studies have identified the associations between environmental phenol and paraben exposures and increased risk of gestational diabetes mellitus (GDM), but no study addressed these exposures as mixtures. As methods have emerged to better assess exposures to multiple chemicals, our study aimed to apply Bayesian kernel machine regression (BKMR) to evaluate the association between phenol and paraben mixtures and GDM.

This study included 64 GDM cases and 237 obstetric patient controls from the University of Oklahoma Medical Center. Mid-pregnancy spot urine samples were collected to quantify concentrations of bisphenol A (BPA), benzophenone-3, triclosan, 2,4-dichlorophenol, 2,5-dichlorophenol, butylparaben, methylparaben, and propylparaben. Multivariable …

Multi-Scale Hybridized Topic Modeling: A Pipeline For Analyzing Unstructured Text Datasets Via Topic Modeling, Keyi Cheng, Stefan Inzer, Adrian Leung, Xiaoxian Shen, Michael Perlmutter, Michael Lindstrom, Joyce Chew, Todd Presner, Deanna Needell

School of Mathematical & Statistical Sciences Faculty Publications

We propose a multi-scale hybridized topic modeling method to find hidden topics from transcribed interviews more accurately and efficiently than traditional topic modeling methods. Our multi-scale hybridized topic modeling method (MSHTM) approaches data at different scales and performs topic modeling in a hierarchical way utilizing first a classical method, Nonnegative Matrix Factorization, and then a transformer-based method, BERTopic. It harnesses the strengths of both NMF and BERTopic. Our method can help researchers and the public better extract and interpret the interview information. Additionally, it provides insights for new indexing systems based on the topic level. We then deploy our method …

Impact Of Ethnicity On Parental Health Outcomes And Experiences After Paediatric Intensive Care Unit Discharge: A Mixed-Methods Systematic Review, Pei Fen Poh, Matthew C. Carey, Jan Hau Lee, Joseph C. Manning, Jos M. Latour

School of Nursing and Midwifery

The impact of ethnicity on parental health outcome after paediatric intensive care unit (PICU) discharge remains unclear. Thirteen medical and healthcare databases, unpublished studies and grey literature were searched up to November 5, 2021. We performed a mixed-method systematic review to understand the impact of ethnicity on parental outcomes after PICU discharge, including eight quantitative and eight qualitative studies. Among 1529 parents included, 1064 (72%) were White. Higher prevalence of post-traumatic stress disorder was seen in Black parents (17% White vs 36% Black, p = .03). Latino ethnicity was found to have protective effect against anxiety as compared to White …

Evidence For The Effects Of Decommissioning Man-Made Structures On Marine Ecosystems Globally: A Systematic Map, Anaëlle J. Lemasson, Paul J. Somerfield, Michaela Schratzberger, Caroline Louise Mcneill, Joana Nunes, Christine Pascoe, Stephen C.L. Watson, Murray S.A. Thompson, Elena Couce, Antony M. Knights

School of Biological and Marine Sciences

Background: Many marine man-made structures (MMS), such as oil and gas platforms or offshore wind turbines, are nearing their ‘end-of-life’ and require decommissioning. Limited understanding of MMS decommissioning effects currently restricts the consideration of alternative management possibilities, often leaving complete removal as the only option in certain parts of the world. This evidence-base describes the ecosystem effects of marine MMS whilst in place and following cessation of operations, with a view to informing decision-making related to their potential decommissioning. Method: The protocol used to create this map was published a priori. Systematic searches of published, literature in English were conducted …

In-Vitro Cell Culture Model To Determine Toxic Effects Of Soil Arsenic Due To Direct Dermal Exposure, Manas Warke, Madeline English, Laura De Marchi, Rohan Deep Sarkar, Srinivas Kannan, Rupali Datta, Smitha Rao

Michigan Tech Publications, Part 1

Arsenic (As) is one of the most toxic environmental pollutants, classified as a Class I carcinogen. Anthropogenic activities have led to an increase in As contamination of soils. Using animal models to study the health impacts of As is time and cost-prohibitive, hence attempts have been made to develop in-vitro cell culture models. However, most studies so far have not represented realistic environmental exposure conditions. We exposed Human Immortalized Keratinocyte (HaCaT) and Primary Human Dermal Fibroblasts (HDFa) cells to the water-soluble fraction of arsenic extracted from As spiked Immokalee soil to study the effect of soil As on skin cells. …

Social Ecological Influences On Treatment Decision-Making In Men Diagnosed With Low Risk, Localised Prostate Cancer, Megan Mcintosh, Melissa J. Opozda, Camille E. Short, Daniel A. Galvão, Rebecca Tutino, Michael Diefenbach, Behfar Ehdaie, Christian Nelson

Research outputs 2022 to 2026

Objective: Individuals diagnosed with low risk, localised prostate cancer (PCa) face a difficult decision between active surveillance (AS) and definitive treatment. We aimed to explore perceived influences on treatment decision-making from the patient and partner's perspectives. Methods: Patients (and partners) who met AS criteria and had chosen their treatment were recruited. Semi-structured individual interviews were conducted via telephone to explore experiences of diagnosis, impact on patient lifestyle, experiences with physicians, treatment preferences/choice, treatment information understanding and needs, and overall decision-making process. Interviews were audio recorded, transcribed verbatim, and analysed using Reflexive Thematic Analysis. Results: Twenty-four male patients (18 chose AS) …

Discovery Of Two Inhibitors Of The Type Iv Pilus Assembly Atpase Pilb As Potential Antivirulence Compounds, Keane J. Dye, Nancy J. Vogelaar, Megan O'Hara, Pablo Sobrado, Webster Santos, Paul R. Carlier, Zhaomin Yang

Chemistry Faculty Research & Creative Works

With the pressing antibiotic resistance pandemic, Anti virulence has been increasingly explored as an alternative strategy against bacterial infections. The bacterial type IV pilus (T4P) is a well-documented virulence factor and an attractive target for small molecules for Anti virulence purposes. The PilB ATPase is essential for T4P biogenesis because it catalyzes the assembly of monomeric pilins into the polymeric pilus filament. Here, we describe the identification of two PilB inhibitors by a high-throughput screen (HTS) in vitro and their validation as effective inhibitors of T4P assembly in vivo. We used Chloracidobacterium thermophilum PilB as a model enzyme to optimize …

Graph Neural Network With Self-Attention And Multi-Task Learning For Credit Default Risk Prediction, Zihao Li, Xianzhi Wang, Lina Yao, Yakun Chen, Guandong Xu, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

We propose a graph neural network with self-attention and multi-task learning (SaM-GNN) to leverage the advantages of deep learning for credit default risk prediction. Our approach incorporates two parallel tasks based on shared intermediate vectors for input vector reconstruction and credit default risk prediction, respectively. To better leverage supervised data, we use self-attention layers for feature representation of categorical and numeric data; we further link raw data into a graph and use a graph convolution module to aggregate similar information and cope with missing values during constructing intermediate vectors. Our method does not heavily rely on feature engineering work and …

Recipegen++: An Automated Trigger Action Programs Generator, Imam Nur Bani Yusuf, Diyanah Abdul Jamal, Lingxiao Jiang, David Lo

Research Collection School Of Computing and Information Systems

Trigger Action Programs (TAPs) are event-driven rules that allow users to automate smart-devices and internet services. Users can write TAPs by specifying triggers and actions from a set of predefined channels and functions. Despite its simplicity, composing TAPs can still be challenging for users due to the enormous search space of available triggers and actions. The growing popularity of TAPs is followed by the increasing number of supported devices and services, resulting in a huge number of possible combinations between triggers and actions. Motivated by such a fact, we improve our prior work and propose RecipeGen++, a deep-learning-based approach that …

Autopruner: Transformer-Based Call Graph Pruning, Cong Thanh Le, Hong Jin Kang, Truong Giang Nguyen, Stefanus Agus Haryono, David Lo, Xuan-Bach D. Le, Huynh Quyet Thang

Research Collection School Of Computing and Information Systems

Constructing a static call graph requires trade-offs between soundness and precision. Program analysis techniques for constructing call graphs are unfortunately usually imprecise. To address this problem, researchers have recently proposed call graph pruning empowered by machine learning to post-process call graphs constructed by static analysis. A machine learning model is built to capture information from the call graph by extracting structural features for use in a random forest classifier. It then removes edges that are predicted to be false positives. Despite the improvements shown by machine learning models, they are still limited as they do not consider the source code …

Efficient Navigation For Constrained Shortest Path With Adaptive Expansion Control, Wenwen Xia, Yuchen Li, Wentian Guo, Shenghong Li

Research Collection School Of Computing and Information Systems

In many route planning applications, finding constrained shortest paths (CSP) is an important and fundamental problem. CSP aims to find the shortest path between two nodes on a graph while satisfying a path constraint. Solving CSPs requires a large search space and is prohibitively slow on large graphs, even with the state-of-the-art parallel solution on GPUs. The reason lies in the lack of effective navigational information and pruning strategies in the search procedure. In this paper, we propose SPEC, a Shortest Path Enhanced approach for solving the exact CSP problem. Our design rationales of SPEC rely on the observation that …

Basalt Fibers For Underwater Fatigue Repair Of Steel Panels, Guillermo Riveros, Emad M. Hassan, Lauren Hudak, Hussam Mahmoud

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Fatigue damage is a major threat to the safety and integrity of many steel structures. Steel hydraulic structures (SHS), in particular, experience fatigue loading during operation and are exposed to harsh environmental conditions that can further reduce fatigue life through mechanisms. The traditional inspection and repair process for SHS is time-consuming and leads to economic losses. Studies investigating the behavior and advantages of using bonded carbon fiber-reinforced polymer (CFRP) to repair fatigue cracks in SHS are lacking. The main objectives of this study are to increase the bonding of CFRP, investigate the effectiveness of different fiber-reinforced polymers, and test different …

Addictive Social Media Use: Examination Of The Psychometric Properties Of The Arabic Bergen Social Media Addiction Scale And The Mediational Role Of Sense Of Control In The Relationship Between Depression And Social Media Addiction, Louis J. Fourie

Theses

The period of COVID-19 has proven to be a turbulent period where extreme psychological trends can be examined due to lockdown procedures, social isolation, and public fear. The use of technology such as social media has increased with research highlighting the harm of overuse. The purpose of the current study is to investigate the psychometric properties of an Arabic translated version of the Bergen Social Media Addiction Scale (BSMAS) to assess for addictive social media use. Secondly, the study further examines the association between depression, social media addiction, and an individual’s sense of control. Specifically, the potential mediational role of …

The Status Of Homogeneous Grouping Implication In English Language Classrooms In The United Arab Emirates, Eman Mohamed Abdelwahab

Theses

This thesis is concerned with the status of homogeneous grouping implication in English language classrooms in the United Arab Emirates public schools. The study aims at exploring students’ and teachers’ perceptions toward homogeneous learning in English language classrooms, encountered challenges and possible suggestions of improvement. The Mixed method was used for data collection and analysis, by using both qualitative (Interview and short-essay questions) and quantitative (Likert-scale questionnaires) data as main sources of data.

The Study sample included 645 participants, consisting of 30 English language teachers and 615 high school students from 13 public schools in the United Arab Emirates. The …

The Impact Of Stem-Based Curriculum On The Development Of Creative Thinking Of High School Students In The United Arab Emirates, Rana Yousef Khalil

Theses

STEM-based curriculum is an integrated structure for teaching science, technology, engineering, and mathematics using project- and inquiry-based learning to produce creative outcomes. This study aims to assess the impact of STEM-based curriculum on the development of creative thinking of high school students while studying physics. Further, this study aims to assess the impact of students’ gender and grade level on the development of creative thinking after implementing a STEM-based curriculum. For this purpose, a quasi-experimental design was used to collect data using the Torrance Test of Creative Thinking (TTCT) and its metrics (fluency, elaboration, flexibility, and originality). In one of …

The Impact Of Internal And External Factors On Female Enrollment In Vocational Training Institutes In The United Arab Emirates: A Phenomenological Qualitative Study, Saada Mubarak Amro

Dissertations

Educational institutes around the world and vocational training institutes, in particular, are concerned with students’ participation and enrollment rates. Great emphasis is placed on the vocational sector and its role in establishing a knowledge-based economy in the United Arab Emirates (UAE), as articulated in the UAE Vision 2021, its economic foresight 2030, and in the recent 50th-anniversary statement released in 2019 by HH Mohammed Rashed Al Maktoum. The importance of this sector is its significance in diversifying the economy, providing employment, and equipping both employed and unemployed nationals with the vocational skills required by local and international markets and industries. …

Impacts Of Intermediate And Long-Term Vitamin D Deficiency On The Murine Gastric Epithelial Cells And Acid Secretion, Shaima Raji Sirajudeen

Dissertations

The biological functions of vitamin D (VD) are diverse. It influences immunological response, cell proliferation and differentiation, and calcium homeostasis. However, over one billion people globally are VD deficient. The VD receptors, VDR and PDIA3, mediate the biological activities of VD. Studies on the biological roles of VD are numerous but very little on the stomach. The stomach is divided into three main parts – forestomach, corpus and antrum. Gastric glands, which make up the functional units of the stomach, are made up of numerous cell lineages and are located in the corpus and antrum, which are the glandular parts …

The Relationship Between School Principals’ Resilience, Job Satisfaction, Self-Efficacy, Perceived Organizational Support, And Thriving In School Leadership Positions In The Uae Government Schools, Noura Abdulla Al Azzani

Dissertations

This dissertation is concerned with school principals who often come across adversities and hardships that challenge their strength and flexibility and impose immense pressure on them. Some of them break; others cope or overcome the adversities. The main objective of this dissertation is to explain why school leaders thrive in the face of their pressing mediating roles whereas others may not even survive within the UAE context. The socially embedded model of thriving at work is adapted to explain the relationship between the thriving level and five variables that could influence and mediate the relationship: the internal factors of resilience, …

Monitoring Quality Of Care In Hepatocellular Carcinoma: A Modified Delphi Consensus, Ashika D. Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey Mccaughan, Eu-Ling Neo, Jennifer Philip, Simone I. Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibballs, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Michael Fink, Mark Goodwin, Christos S. Karapetis, Miriam T. Levy, Kate Muller, James O'Beirne, David Pryor, James Seow, Nicholas Shackel, Caroline Tallis, Nick Butler, John K. Olynyk, Kate Reed-Cox, John R. Zalcberg, Stuart K. Roberts

Research outputs 2022 to 2026

Although there are several established international guidelines on the management of hepatocellular carcinoma (HCC), there is limited information detailing specific indicators of good quality care. The aim of this study was to develop a core set of quality indicators (QIs) to underpin the management of HCC. We undertook a modified, two-round, Delphi consensus study comprising a working group and experts involved in the management of HCC as well as consumer representatives. QIs were derived from an extensive review of the literature. The role of the participants was to identify the most important and measurable QIs for inclusion in an HCC …

Wetting Of Paper Towels: A Method To Determine The Two-Dimensional Absorption Capacity, Hossein Abedsoltan

Chemical and Biochemical Engineering Faculty Research & Creative Works

This study proposes a method to determine the two-dimensional absorption capacity of paper towels. Individual plies were tested to minimize the effects of transverse wicking on wetting. The method involves arbitrary point source injection of liquid into the towel surface while recording microscopic images of the wetted areas. The samples were selected from the main manufacturing processes: conventional wet pressing and through-air drying. Wetting graphs that illustrate the dynamic and static wetting behaviors were generated. The driving force was found to have a negligible effect on the maximum wetted area. The maximum wetted area and the paper grammage were used …

Transcriptional Regulatory Network Topology With Applications To Bio-Inspired Networking: A Survey, Satyaki Roy, Preetam Ghosh, Nirnay Ghosh, Sajal K. Das

Computer Science Faculty Research & Creative Works

The advent of the edge computing network paradigm places the computational and storage resources away from the data centers and closer to the edge of the network largely comprising the heterogeneous IoT devices collecting huge volumes of data. This paradigm has led to considerable improvement in network latency and bandwidth usage over the traditional cloud-centric paradigm. However, the next generation networks continue to be stymied by their inability to achieve adaptive, energy-efficient, timely data transfer in a dynamic and failure-prone environment - the very optimization challenges that are dealt with by biological networks as a consequence of millions of years …

Digital Services Trade And Trade Agreements, Henry S. Gao

Research Collection Yong Pung How School Of Law

Trade agreements have become the main forum for the regulation of digital services trade issues over the past decade. This chapter provides a comprehensive examination of the regulation of digital services trade in trade agreements, first reviewing the rules in the World Trade Organization (WTO), then comparing the approaches between the United States (US), the People’s Republic of China (PRC), and the European Union (EU), and explaining the reasons for their deep differences. This chapter further analyzes such provisions in trade agreements in Asia and the Pacific, which has become one of the most dynamic regions in terms of new …

The Investment Chapter In The Regional Comprehensive Economic Partnership: Enhanced Rules Without Enforcement Mechanism, Henry S. Gao

Research Collection Yong Pung How School Of Law

This Chapter examines the legal rules in the investment chapter in the Regional Comprehensive Economic Partnership (RCEP). It starts with an overview and summary of the main provisions in the chapter, followed by an assessment of the rules by comparing established free trade agreements (FTAs), especially the Comprehensive and Progressive Trans-Pacific Partnership. In particular, it notes that the chapter, whilst largely following the established approaches to investment in other FTAs, also includes important twists to the common rules to favour the host states. The last part discusses the conspicuous absence of an investor-state dispute settlement mechanism, its pros and cons, …

Book Review: Mediation Ethics: A Practitioner's Guide Edited By Omer Shapira Ed, Dorcas Quek Anderson

Research Collection Yong Pung How School Of Law

A review of the book Mediation ethics: A practitioner's guide, edited by Omer Shapira. Mediation ethics have been consistently featured in mediation training courses and mediation ethical principles have also been encapsulated in mediation providers’ codes of conduct for mediators. However, mediation ethics have probably inspired fewer publications and academic discussions than the popular topic of mediation skills. It is thus timely that Shapira has edited this publication focusing on mediation ethics. Published in 2021, this collection of reflections on mediation ethics has been written primarily for the American mediation profession, with frequent references made to the US Model Standards …

Amplitude Synchronization Of Spontaneous Activity Of Medial And Lateral Temporal Gyri Reveals Altered Thalamic Connectivity In Patients With Temporal Lobe Epilepsy, Anish V. Sathe, Michael Kogan, Kichang Kang, Jingya Miao, Mashaal Syed, Isaiah Ailes, Caio M. Matias, Devon Middleton, Feroze B. Mohamed, Scott Faro, Joseph Tracy, Ashwini Sharan, Mahdi Alizadeh

Department of Neurosurgery Faculty Papers

In this study, we examined whether amplitude synchronization of medial (MTL) and lateral (LTL) temporal lobes can detect unique alterations in patients with MTL epilepsy (mTLE) with mesial temporal sclerosis (MTS). This was a retrospective study of preoperative resting-state fMRI (rsfMRI) data from 31 patients with mTLE with MTS (age 23-69) and 16 controls (age 21-35). fMRI data were preprocessed based on a multistep preprocessing pipeline and registered to a standard space. Using each subject's T1-weighted scan, the MTL and LTL were automatically segmented, manually revised and then fit to a standard space using a symmetric normalization registration algorithm. Dual …

Privacy Qui Tam, Peter Ormerod

Faculty Publications

Privacy law keeps getting stronger, but surveillance-based businesses have proven immune to these new legal regimes. The disconnect between privacy law in theory and in practice is a multifaceted problem, and one critical component is enforcement.

Today, most privacy laws are enforced by governmental regulators—the Federal Trade Commission, the nascent California Privacy Protection Agency, and state attorneys general. An enduring impasse for proposed privacy laws is whether to supplement public enforcement by using a private right of action to authorize individuals to enforce the law.

Both of these conventional enforcement schemes have significant shortcomings. Public enforcement has proven inadequate because …

“Everything…Fell Apart Once Covid-19 Hit”—Leveraging The Covid-19 Response To Strengthen Public Health Activities Toward Ending The Hiv Epidemic: A Qualitative Study, Samantha A. Devlin, Moctezuma Garcia, Kayo Fujimoto, Camden Hallmark, Marlene Mcneese, John Schneider, Moira C. Mcnulty

Faculty Research, Scholarly, and Creative Activity

COVID-19 caused widespread disruption of activities for Ending the HIV Epidemic (EHE). In this study we assessed public health perspectives on leveraging the COVID-19 response to advance the goals of EHE. We conducted a qualitative study with 33 public health partners in the Midwestern and Southern United States from October 2020 to February 2022. Participants were asked how the strategies developed for COVID-19 could be applied to the HIV epidemic. Interviews were recorded, transcribed, and examined using rapid qualitative analysis. Four themes emerged: (1) Rebuilding teams and adapting culture for success in EHE activities; (2) Recognizing and modernizing the role …

How I Perform Totally Endoscopic Robotic Mitral Valve Repair., Colin C Yost, Jake L Rosen, Meagan Wu, Caroline M Komlo, Jordan E Goldhammer, T Sloane Guy

Department of Medicine Faculty Papers

A sixty-two-year-old male presented with significant symptoms related to severe mitral regurgitation with posterior leaflet flail and prolapse on transesophageal echocardiogram (TEE). Preoperative computed tomography (CT) angiography showed normal caliber thoracoabdominal aorta and patent access vessels. The patient underwent totally endoscopic robotic mitral valve repair (rMVr) with left atrial CryoMAZE procedure.

Genome-Wide Meta-Analyses Reveal Novel Loci For Verbal Short-Term Memory And Learning, Jari Lahti, Samuli Tuominen, Qiong Yang, Giulio Pergola, Shahzad Ahmad, Najaf Amin, Nicola J Armstrong, Alexa Beiser, Katharina Bey, Joshua C Bis, Eric Boerwinkle, Jan Bressler, Archie Campbell, Harry Campbell, Qiang Chen, Janie Corley, Simon R Cox, Gail Davies, Philip L De Jager, Eske M Derks, Jessica D Faul, Annette L Fitzpatrick, Alison E Fohner, Ian Ford, Myriam Fornage, Zachary Gerring, Hans J Grabe, Francine Grodstein, Vilmundur Gudnason, Eleanor Simonsick, Elizabeth G Holliday, Peter K Joshi, Eero Kajantie, Jaakko Kaprio, Pauliina Karell, Luca Kleineidam, Maria J Knol, Nicole A Kochan, John B Kwok, Markus Leber, Max Lam, Teresa Lee, Shuo Li, Anu Loukola, Tobias Luck, Riccardo E Marioni, Karen A Mather, Sarah Medland, Saira S Mirza, Mike A Nalls, Kwangsik Nho, Adrienne O'Donnell, Christopher Oldmeadow, Jodie Painter, Alison Pattie, Simone Reppermund, Shannon L Risacher, Richard J Rose, Vijay Sadashivaiah, Markus Scholz, Claudia L Satizabal, Peter W Schofield, Katharina E Schraut, Rodney J Scott, Jeannette Simino, Albert V Smith, Jennifer A Smith, David J Stott, Ida Surakka, Alexander Teumer, Anbupalam Thalamuthu, Stella Trompet, Stephen T Turner, Sven J Van Der Lee, Arno Villringer, Uwe Völker, Robert S Wilson, Katharina Wittfeld, Eero Vuoksimaa, Rui Xia, Kristine Yaffe, Lei Yu, Habil Zare, Wei Zhao, David Ames, John Attia, David A Bennett, Henry Brodaty, Daniel I Chasman, Aaron L Goldman, Caroline Hayward, M Arfan Ikram, J Wouter Jukema, Sharon L R Kardia, Todd Lencz, Markus Loeffler, Venkata S Mattay, Aarno Palotie, Bruce M Psaty, Alfredo Ramirez, Paul M Ridker, Steffi G Riedel-Heller, Perminder S Sachdev, Andrew J Saykin, Martin Scherer, Peter R Schofield, Stephen Sidney, John M Starr, Julian Trollor, William Ulrich, Michael Wagner, David R Weir, James F Wilson, Margaret J Wright, Daniel R Weinberger, Stephanie Debette, Johan G Eriksson, Thomas H Mosley, Lenore J Launer, Cornelia M Van Duijn, Ian J Deary, Sudha Seshadri, Katri Räikkönen

Faculty, Staff and Student Publications

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during …

Effects Of Escalating Temporary Mechanical Circulatory Support In Patients With Worsening Cardiogenic Shock, Iyad N Isseh, Sarah Gorgis, Carina Dagher, Shivani Sharma, Mir B Basir, Sachin Parikh

The Texas Heart Institute Journal

BACKGROUND: Cardiogenic shock-related mortality is substantial, and temporary mechanical circulatory support (MCS) devices are frequently used. The authors aimed to describe patient characteristics and outcomes in patients with worsening cardiogenic shock requiring escalation of temporary MCS devices.

METHODS: Worsening cardiogenic shock was defined as persistent hypotension, increasing doses of vasopressors/inotropes, worsening hypoperfusion, or worsening invasive hemo-dynamics. Escalation of temporary MCS devices was defined as adding or exchanging an existing MCS device. Variables were evaluated by logistic regression models and receiver operating characteristic curves.

RESULTS: From July 1, 2016, to July 1, 2018, a total of 81 consecutive patients experienced worsening …