Digital Commons Network^™

Uremic Myopathy And Mitochondrial Dysfunction In Kidney Disease, Eurico Serrano, Diana Whitaker-Menezes, Zhao Lin, Megan Roche, Maria Paula Martinez Cantarin

Kimmel Cancer Center Faculty Papers

Alterations in muscle structure and function in chronic kidney disease (CKD) patients are associated with poor outcomes. As key organelles in muscle cell homeostasis, mitochondrial metabolism has been studied in the context of muscle dysfunction in CKD. We conducted a study to determine the contribution of oxidative metabolism, glycolysis and fatty acid oxidation to the muscle metabolism in CKD. Mice developed CKD by exposure to adenine in the diet. Muscle of CKD mice showed significant weight loss compared to non-CKD mice, but only extensor digitorum longus (EDL) muscle showed a decreased number of fibers. There was no difference in the …

Blockade Of Fgf2/Fgfr2 Partially Overcomes Bone Marrow Mesenchymal Stromal Cells Mediated Progression Of T-Cell Acute Lymphoblastic Leukaemia, Chen Tian, Yueyang Li, Lina Wang, Junqi Si, Yaxin Zheng, Junnan Kang, Yafei Wang, M James You, Guoguang Zheng

Faculty, Staff and Student Publications

The development of acute lymphoblastic leuakemia (ALL) is partly attributed to the effects of bone marrow (BM) microenvironment, especially mesenchymal stromal cells (MSCs), which interact bilaterally with leukaemia cells, leading to ALL progression. In order to find MSCs-based microenvironment targeted therapeutic strategies, Notch1-induced T-cell ALL (T-ALL) mice models were used and dynamic alterations of BM-MSCs with increased cell viability during T-ALL development was observed. In T-ALL mice derived stroma-based condition, leukaemia cells showed significantly elevated growth capacity indicating that MSCs participated in leukaemic niche formation. RNA sequence results revealed that T-ALL derived MSCs secreted fibroblast growth factor 2 (FGF2), which …

The Role Of Telehealth In Reducing Hospital Readmissions For Heart Failure Patients, Tommy Lee Bratcher

Graduate Theses, Dissertations, and Capstones

Heart failure affects over six million people annually, and is expected to increase to over eight million by 2030. Over 60 million people live in the rural United States. Telehealth is a tool to improve access to care, provide early intervention, and follow up with patients within 48 hours of a hospital discharge. Utilizing Telehealth to conduct a medication reconciliation within 48 hours of discharge to address any medication errors or admission, and reinforce adherence is a way to improve access to care to those living in rural areas.

Utilization Of A Multimodal De-Escalation Class To Improve Staff Confidence When Caring For Behaviorally Escalating Patients, Tara B. Neuner

Graduate Theses, Dissertations, and Capstones

Workplace violence is a common challenge seen in the healthcare settings across the world. This problem is steadily increasing in all types of hospitals, including a level one trauma center located in an urban area. There has been a steady rise in the number of assaults and workplace violence reported from bedside staff at this hospital. The leadership of the organization formed a work group to help combat the workplace violence and staff assaults that were occurring. In this process, a behavior response team was created to help nursing staff with escalating behavior in patients, and to help de-escalate the …

Telehealth And Hospital Readmissions For Heart Failure Patients: A Literature Review, Tommy Lee Bratcher

Graduate Theses, Dissertations, and Capstones

Currently heart failure affects over six million people and is expected to increase to over eight million people by 20230. The US Census Bureau estimates over 60 million people live in a rural setting. This literature review seeks to determine the state of the science regarding the utilization of Telehealth to reduce heart failure readmissions in rural areas.

Crafting Effective Regulatory Policies For Psychedelics: What Can Be Learned From The Case Of Cannabis?, Amanda J. Abraham, Christina M. Andrews Ph.D., Samantha J. Harris, Melissa M. Westlake, Colleen M. Grogan

Faculty Publications

Importance: Medicaid is a key policy lever to improve opioid use disorder treatment, covering approximately 40% of Americans with opioid use disorder. Although approximately 70% of Medicaid beneficiaries are enrolled in comprehensive managed care organization (MCO) plans, little is known about coverage and prior authorization (PA) policies for medications for opioid use disorder (MOUD) in these plans. Objective: To compare coverage and PA policies for buprenorphine, methadone, and injectable naltrexone across Medicaid MCO plans and fee-for-service (FFS) programs and across states. Design, Setting, and Participants: This cross-sectional study analyzed MOUD data from 266 Medicaid MCO plans and FFS programs in …

Introduction To Film, 2nd Edition, Teresa Fisher

Open Educational Resources

This textbook explores the world of cinema providing a students a look at the various elements of filmmaking to develop an appreciation for the film form. The textbook begins with a look at film history and the fundamentals of cinematic language. It then continues looking at film through a different lens for each chapter -- mise-en-scene, narrative, cinematography, editing, acting, and sound. The book ends with a look at documentary films, experimental films, and animation.

Technology-Based Obesity Prevention Interventions Among Hispanic Adolescents In The United States: Scoping Review, Erica G Soltero, Callie Lopez, Edith Hernandez, Teresia M O'Connor, Debbe Thompson

Children’s Nutrition Research Center Staff Publications

Background: Given that today's adolescents are digital front-runners, technology-based obesity prevention strategies are age-appropriate for this population. The use of remote and wireless technologies may be suitable for extending the reach and engagement of obesity prevention efforts among high-risk Hispanic youths, as this subgroup is disproportionately affected by barriers that limit participation in traditional, in-person interventions.

Objective: The purpose of this scoping review was to examine the intervention and sample characteristics of technology-based obesity prevention interventions among Hispanic adolescents. We also examined feasibility criteria to assess the acceptability and appropriateness of technology-based strategies among Hispanic youths.

Methods: A comprehensive search …

Senior Food Insecurity In The Usa: A Systematic Literature Review, Bertille Octavie Mavegam Tango Assoumou, Courtney Coughenour, Amruta Godbole, Ian Mcdonough

Environmental & Global Health Faculty Research

Objective:

Understanding the factors associated with senior food insecurity is key to understanding senior-specific needs to develop targeted interventions and ultimately lower the prevalence and the incidence of food insecurity. We aimed to systematically review published literature and summarise the associated factors of food insecurity in older adults in the USA.

Design:

We searched PubMed, Scopus, Web of science, EconLit and JSTOR databases for peer-reviewed articles published in English between January 2005 and September 2019 that assessed food security or its associated factors for US adults aged 60 years and older. After a two-step screening process, twenty articles were retained …

Nursing Students' Self-Efficacy To Care For Older Adults In Acute Care Settings In Ghana: A Mixed Method Study, Diana Abudu-Birresborn

Dissertations

Self-efficacy has been reported to serve as a motivator for goal achievement and to impact care quality and career development choices. Understanding nursing students' self-efficacy to care for older adults can provide an opportunity to identify gaps and develop strategies to shape nursing students' interest in caring for older adults. This study sought to identify the relationship between nursing students' knowledge about, attitudes towards, and self-efficacy to care for older adults and explored nursing students' understanding of their self-efficacy to care for older adults. The study also examined stakeholders' perceptions about nursing students' self-efficacy to care for older adults and …

Growth In High-Paying Jobs: Mountain West Metros, Joshua Padilla, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet examines data from a Stessa report titled, “U.S. Cities with the Largest Growth in High-Paying Jobs.” Data are presented for 25 metros in the Mountain West (Arizona, Colorado, Nevada, New Mexico, and Utah).

Draft Final 2022 Residential Metals Abatement Program (Rmap) Cherokee Park Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final 2022 Residential Metals Abatement Program (Rmap) Koprivica Park Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Mitochondrial Protective Effects Caused By The Administration Of Mefenamic Acid In Sepsis, Diogo Dominguini, Monique Michels, Leticia B Wessler, Emilio L Streck, Tatiana Barichello, Felipe Dal-Pizzol

Faculty, Staff and Student Publications

The pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), mitochondrial and oxidative damages. One of the primary essential oxidation products is 8-oxoguanine (8-oxoG), and its accumulation in mitochondrial DNA (mtDNA) induces cell dysfunction and death, leading to the hypothesis that mtDNA integrity is crucial for maintaining neuronal function during sepsis. In sepsis, the modulation of NLRP-3 activation is critical, and mefenamic acid (MFA) is a potent drug that can reduce inflammasome activity, attenuating the acute cerebral inflammatory process. Thus, this study aimed to evaluate the administration of MFA and its implications for …

The Mid‑Pleistocene Transition: A Delayed Response To An Increasing Positive Feedback?, Anne Willem Omta, Peter Thomas

Faculty Scholarship

Glacial–interglacial cycles constitute large natural variations in Earth’s climate. The Mid-Pleistocene Transition (MPT) marks a shift of the dominant periodicity of these climate cycles from ∼40 to ∼100 kyr. Recently, it has been suggested that this shift resulted from a gradual increase in the internal period (or equivalently, a decrease in the natural frequency) of the system. As a result, the system would then have locked to ever higher multiples of the external forcing period. We find that the internal period is sensitive to the strength of positive feedbacks in the climate system. Using a carbon cycle model in which …

2022-2023 Performance Forum - November 4, 2022, Elisabeth Thomashoff, Alexander Walden, Olivia Oakland, Sheng Yuan Kuan, Esther Platt, Ruvit Bracho, Sheila Browne, Jon Cruz, Jafet Diaz, Matthew Montelione, Baran Zolfaghari, Miguelangel Garcia Marquez, Fabiola Parra, Jeremiah Grace

Performance Forum

No abstract provided.

"Musical Smiles": The Cuban Contradanza And Its Impact On Latin American Music, Jeriel K. Jorguenson

Electronic Theses and Dissertations Archive

This study examines the influence of the Cuban contradanza, paying special interest on the lives of two Cuban figures who advanced the form most: Manuel Saumell (1818-1870) and Ignacio Cervantes (1847-1905). The document will begin with an introduction to Cuba in the nineteenth century in order to learn about the environment in which these two composers were forged. Next, the history of the contradanza will be assessed, detailing how the dance was performed and how the music was structured. Following this, the lives of Saumell and Cervantes will be detailed, from their biographies and training to the danzas which they …

Diagnostic Accuracy Of Artificial Intelligence For Detecting Gastrointestinal Luminal Pathologies: A Systematic Review And Meta-Analysis, Om Parkash, Asra Tus Saleha Siddiqui, Uswa Jiwani, Fahad Rind, Zahra Ali Padhani, Arjumand Rizvi, Zahra Hoodbhoy, Jai K. Das

Section of Gastroenterology

Background: Artificial Intelligence (AI) holds considerable promise for diagnostics in the field of gastroenterology. This systematic review and meta-analysis aims to assess the diagnostic accuracy of AI models compared with the gold standard of experts and histopathology for the diagnosis of various gastrointestinal (GI) luminal pathologies including polyps, neoplasms, and inflammatory bowel disease.
Methods: We searched PubMed, CINAHL, Wiley Cochrane Library, and Web of Science electronic databases to identify studies assessing the diagnostic performance of AI models for GI luminal pathologies. We extracted binary diagnostic accuracy data and constructed contingency tables to derive the outcomes of interest: sensitivity and specificity. …

The Enigma Of Primary Hypertension In Childhood, Bonita Falkner

Department of Medicine Faculty Papers

Beginning in the 1970s, hypertension in children and adolescents has been defined as systolic and/or diastolic blood pressure (BP) that is equal to or greater than the 95th percentile of the normal BP distribution in healthy children. The definition of hypertension in adults is based on longitudinal data that links a BP level with an increased risk for subsequent adverse outcomes related to hypertension including heart failure, kidney failure, stroke, or death. The statistical definition of hypertension continues to be used in childhood because there have been no data that link a BP level in childhood with a heightened risk …

Preventive Behaviors And Information Sources During Covid-19 Pandemic: A Cross-Sectional Study In Japan, Manae Uchibori, Cyrus Ghaznavi, Michio Murakami, Akifumi Eguchi, Hiroyuki Kunishima, Satoshi Kaneko, Keiko Maruyama-Sakurai, Hiroaki Miyata, Shuhei Nomura

2020-Current year OA Pubs

BACKGROUND: individual preventive behaviors are one of the key measures needed to prevent the spread of COVID-19. This study sought to identify the factors associated with the adoption of COVID-19 preventive measures, focusing specifically on information sources.

METHODS: we conducted a nationally representative cross-sectional survey of 30,053 Japanese adults in February 2021. The survey asked about socioeconomic, health-related, and psychological characteristics, attitudes toward immunization, and the use of information sources regarding COVID-19. We have constructed multivariable logistic regression to estimate the factors associated with the adoption of three preventive measures: 3Cs avoidance, hand hygiene and respiratory hygiene.

RESULTS: socioeconomic variables, …

Heidegger And The Origin Of Authenticity, John J. Preston

USF Tampa Graduate Theses and Dissertations

Since the publication of Sein und Zeit in 1927, scholars have coupled Martin Heidegger’s reflections on authenticity with a rich tradition of thought which reminds us that philosophy can, from time to time, function as a catalyst for self-discovery. While this function is an undeniable feature of Heideggerian authenticity, I would like to suggest that it is secondary to the role that authenticity plays in Heidegger’s philosophical investigations. By analyzing the full phenomena of authenticity and tracing its first technical uses back to Heidegger’s early lectures on Aristotle, I show that Heidegger’s methodological breakthrough in the early 1920s, the development …

Closing The Gap: Supporting Equity, Diversity, & Inclusivity Plans In The Modern Library, Jameson Paul Ghalioungui

Library Philosophy and Practice (e-journal)

Equity, diversity, and inclusivity (EDI) plans and initiatives are at the forefront of many library’s strategic planning (Mallon, 2019). Efforts, big or small, such as mandatory all-staff EDI training sessions (DGPL, 2021), EDI focused patron programming, or simply promoting the local library as a place of opportunity for all (ALA, 2019), demonstrate the American Library Association (ALA)’s Core Values in practice (ALA, 2006). The ALA has historically promoted themselves as supporters, allies, and anti-racists, playing an important role in many libraries’ strategic plans and philosophies. But, despite libraries being regarded as the ‘most inclusive’ institutions in the United States (Jaeger, …

Human Amniotic Membrane As A Dural Substitute In Neurosurgery: A Systematic Review, Zara Shah, Saqib Kamran Bakhshi, Mohammad Hamza Bajwa, Mujtaba Khalil, Michael C. Dewan, Muhammad Shahzad Shamim

Medical College Documents

Background: Several studies have highlighted the use of human amniotic membrane (HAM) in neurosurgical procedures as an effective dural substitute. HAM has inherent antifibrotic and anti-inflammatory properties and exhibits immunomodulatory effect that makes it an ideal dural substitute. Other advantages including easy availability, low cost of procurement, and storage also render it a promising dural substitute especially in low- and middle-income countries.
Methods: A systematic literature search was performed using PubMed, Scopus, and Google Scholar databases, using the search terms "human amniotic membrane," "dural repair," and "neurosurgery." To be eligible for inclusion in our review, papers had to report primary …

Roundtable 1: Putting It All Together: Utilizing Student-Curated Portfolio Projects To Engage And Immerse Students From Week 1, Christi M. Navarro

Learning and Educational Center Virtual Teaching and Learning Conference

It is not uncommon for educators to assign semester- or weeks-long projects giving students ample time to plan and execute, only to realize that many students choose to complete the assignment the night before the due date. Although the results may vary in the quality of submissions, the intent of educators to have students synthesize course content over the span of the semester may fall flat. The objective of this session is to present a multi-faceted portfolio project that will meaningfully engage students and synthesize course concepts from the onset.

Learning Outcomes:

1. Define the Gradual Release of Responsibility Framework.
2. Describe …

Paying For Our Keep: Grasslands Decision Support In More-Developed Countries, Andrew D. Moore

IGC Proceedings (1977-2023)

“Models in grassland science have come to stay, and so they must be made to pay for their keep. To do that, it will be necessary to improve their scientific sophistication and their management relevance...” (Seligman, 1993).

Decision support (DS) tools in grassland agriculture have also come to stay. This review will examine the ways and means by which DS tools are being made to pay for their keep, with a focus upon DS efforts from the last decade and on the lessons that arise for those who develop DS tools for grasslands. A survey of the present state of …

A Qualitative Investigation: Black & Brown Men Retention And Recruitment In The Grow Your Own Program And Partners Colleges Of Education And Universities, Sunni Ali, Alberto Lopez

Journal of Research Initiatives

Three decades ago, the U.S. Department of Education identified increasing the number of teachers of color as a priority. Three decades later, the nation is still confronting a gap between the number of students of color and teachers of color serving in our classrooms. Black and brown men make up less than three percent of the teaching workforce (Bryk, A., Gomez, L., Grunow, A. 2011). Regardless of race, all students benefit from having black and brown male teachers working in urban settings because it counters the deficit model while affirming minority male students' cultural efficacy. Through focus groups, we interviewed …

A Glimpse Behind The Curtain: The Detailed Structure Of The May Literacy Center, A University-Based Literacy Clinic, Brian M. Flores, Amber Meyer

Journal of Research Initiatives

Literacy centers have existed in the United States since the 1920s and have seen many changes over their vast and essential history. Initially, clinics focused on remediation with a deficit view that positioned struggling readers as lazy and unmotivated. Over time, clinics shifted to a medical model, which also held a deficit view that involved pathologizing, testing, and diagnosing to "fix what was wrong" with the struggling reader. Today, university-based reading clinics focus on research-based literacy practices providing opportunities for undergraduate teacher candidates and graduate students to support struggling readers. Research on literacy clinics primarily focused on funding, student demographics, …

Not All Competitions Are The Same: Digital Game-Based Learning Environments That Incorporate Competition Facilitates Students' Learning Motivation, Yong Zeng, John E. Mceneaney

Journal of Research Initiatives

This text presents an argument that competition, as a pedagogical design element, facilitates students’ learning motivation in digital game-based learning environments (DGBLEs). Since competition has long been regarded as an adverse pedagogical element for fostering students’ learning motivation, a considerable proportion of educators and researchers in the U.S. have a variety of concerns about implementing competition in educational practices. However, the function of competition in DGBLEs could be fundamentally different. By reviewing major concerns about competition, this text refutes two major concerns about competition and claims that DGBLEs that incorporate competition facilitate students' learning motivation

Exercise Based Cancer Rehabilitation Program Improves Phase Angle In Breast Cancer Survivors, Trevor Short, Cheri Teranishi-Hashimoto, Paulette Yamada

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 1444-1456, 2022. Phase angle (PhA) is an index of cell membrane integrity and prognostic indicator of survival and quality of life in cancer survivors. The efficacy of exercise-based cancer rehabilitation programs (ExCR) on PhA is unknown. To assess the effect of ExCR on PhA in breast cancer survivors. Fifty-nine female breast cancer survivors (61 ± 9 years) were referred to the ExCR by their oncologist and participated in one-on-one exercise-based training for 90 minutes, 3 times a week, for 12 weeks. Training sessions included 45 minutes of resistance training at intensities between 40-85% of …

The Association Of Field Test Outcomes With Peak Oxygen Uptake In Patients With Cystic Fibrosis: A Systematic Review, Natália E. Campos, Fernanda M. Vendrusculo, Gisele A. Da Costa, Ingrid S. De Almeida, Nicolas A. Becker, Márcio V F Donadio

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 1381-1394, 2022. The purpose of the study was to evaluate the association of field test outcomes with peak oxygen uptake (VO₂peak) in patients with cystic fibrosis (CF) and to describe the main prediction equations available. Data searches were performed in five databases (Pubmed, Embase, LILACs, Scopus and Web of Science) and also in the reference lists of articles included. The following inclusion criteria were used: studies including individuals with CF, presenting both a field test and a cardiopulmonary exercise testing (CPET), and describing a predictive equation or coefficient of correlation/determination. Case studies, …