Digital Commons Network^™

Exome Sequencing Efficacy And Phenotypic Expansions Involving Esophageal Atresia/Tracheoesophageal Fistula Plus, Mary R Sy, Jaynee Chauhan, Katrina Prescott, Aliza Imam, Alison Kraus, Ana Beleza, Lee Salkeld, Saraswati Hosdurga, Michael Parker, Pradeep Vasudevan, Lily Islam, Himanshu Goel, Nicole Bain, Soo-Mi Park, Shehla Mohammed, Klaus Dieterich, Charles Coutton, Véronique Satre, Gaëlle Vieville, Alan Donaldson, Claire Beneteau, Jamal Ghoumid, Kris Van Den Bogaert, Anneleen Boogaerts, Elise Boudry, Clémence Vanlerberghe, Florence Petit, Laura Bernardini, Barbara Torres, Teresa Mattina, Diana Carli, Giorgia Mandrile, Michele Pinelli, Nicola Brunetti-Pierri, Katherine Neas, Rachel Beddow, Pernille M Tørring, Flavio Faletra, Beatrice Spedicati, Paolo Gasparini, Alessandro Mussa, Giovanni Battista Ferrero, Anne Lampe, Wayne Lam, Weimin Bi, Carlos A Bacino, Akela Kuwahara, Jeffrey O Bush, Xiaonan Zhao, Pamela N Luna, Chad A Shaw, Jill A Rosenfeld, Daryl A Scott

Faculty, Staff and Students Publications

Esophageal atresia/tracheoesophageal fistula (EA/TEF) is a life-threatening birth defect that often occurs with other major birth defects (EA/TEF+). Despite advances in genetic testing, a molecular diagnosis can only be made in a minority of EA/TEF+ cases. Here, we analyzed clinical exome sequencing data and data from the DECIPHER database to determine the efficacy of exome sequencing in cases of EA/TEF+ and to identify phenotypic expansions involving EA/TEF. Among 67 individuals with EA/TEF+ referred for clinical exome sequencing, a definitive or probable diagnosis was made in 11 cases for an efficacy rate of 16% (11/67). This efficacy rate is significantly lower …

Long-Term Relugolix Combination Therapy For Symptomatic Uterine Leiomyomas, Ayman Al-Hendy, Andrea S Lukes, Alfred N Poindexter, Roberta Venturella, Claudio Villarroel, Laura Mckain, Yulan Li, Rachel B Wagman, Elizabeth A Stewart

Faculty, Staff and Students Publications

OBJECTIVE: In the LIBERTY 1 and LIBERTY 2 placebo-controlled trials, once-daily relugolix combination therapy reduced menstrual blood loss volume and pain in women with heavy menstrual bleeding associated with uterine leiomyomas and was well tolerated, with preservation of bone mineral density (BMD) through 24 weeks. Here we report the long-term efficacy and safety of relugolix combination therapy treatment for up to 52 weeks.

METHODS: Women with uterine leiomyoma-associated heavy menstrual bleeding who completed any treatment arm in either the LIBERTY 1 or LIBERTY 2 trial were eligible to enroll in a 28-week long-term extension study. All participants received once-daily relugolix …

An Open-Access, Interactive Decision-Support Tool To Facilitate Guideline-Driven Care For Hepatocellular Carcinoma, Robert J Wong, Channa Jayasekera, Patricia Jones, Fasiha Kanwal, Amit G Singal, Aijaz Ahmed, Robert Taglienti, Zobair Younossi, Laura Kulik, Neil Mehta

Faculty, Staff and Students Publications

Hepatocellular carcinoma (HCC) is increasing in incidence and is a leading cause of cancer-related mortality worldwide. Adherence to HCC surveillance guidelines and appropriate treatment triage of liver lesions may improve receipt of curative-intent treatment and improved survival. Late-stage HCC diagnosis reflects sub-optimal implementation of effective HCC surveillance, whereas inappropriate treatment triage or linkage to care accounts for the non-receipt of curative-intent in close to half of early-stage HCC in the USA. A free, open-access decision-support tool for liver lesions that incorporates current guideline recommendations in a user-friendly interface could improve appropriate and timely triage of patients to appropriate care. This …

Renal Osteodystrophy: A Historical Review Of Its Origins And Conceptual Evolution, Garabed Eknoyan, Sharon M Moe

Faculty, Staff and Students Publications

Long considered an inert supporting framework, bone studies went neglected until the 17th century when they began as descriptive microscopic studies of structure which over time progressed into that of chemistry and physiology. It was in the mid-19th century that studies evolved into an inquisitive discipline which matured into the experimental investigation of bone in health and disease in the 20th century, and ultimately that of molecular studies now deciphering the genetic language of bone biology. These fundamental studies were catalyzed by increasing clinical interest in bone disease. The first bone disease to be identified was rickets in 1645. Its …

Understanding Post-Covid-19 Interstitial Lung Disease (Ild): A New Fibroinflammatory Disease Entity, Puja Mehta, Ivan O Rosas, Mervyn Singer

Faculty, Staff and Students Publications

Immunomodulation and immunity from vaccination and natural infection have reduced mortality from coronavirus disease 2019 (COVID-19). However, there are ongoing concerns regarding emerging variants and residual pulmonary sequelae in survivors, given that the lungs are the principal site for the triumvirate of infection, inflammation and injury. The initial waves of acute, severe COVID-19 were profoundly inflammatory, usually manifest as organising pneumonia ± acute respiratory distress syndrome (ARDS). The extent of the fibrogenic potential of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the modifiability of the pathogenic processes and disease course are unclear. Interestingly patients can develop ‘post-COVID interstitial lung disease’ …

Loss Of Wnt4 In The Gubernaculum Causes Unilateral Cryptorchidism And Fertility Defects, Abhishek Seth, Juan C Bournat, Olga Medina-Martinez, Armando Rivera, Joshua Moore, Hunter Flores, Jill A Rosenfeld, Liya Hu, Carolina J Jorgez

Faculty, Staff and Students Publications

Undescended testis (UDT) affects 6% of male births. Despite surgical correction, some men with unilateral UDT may experience infertility with the contralateral descended testis (CDT) showing no A-dark spermatogonia. To improve our understanding of the etiology of infertility in UDT, we generated a novel murine model of left unilateral UDT. Gubernaculum-specific Wnt4 knockout (KO) mice (Wnt4-cKO) were generated using retinoic acid receptor β2-cre mice and were found to have a smaller left-unilateral UDT. Wnt4-cKO mice with abdominal UDT had an increase in serum follicle-stimulating hormone and luteinizing hormone and an absence of germ cells in the undescended testicle. Wnt4-cKO mice …

Growth Parameters In Children With Achondroplasia: A 7-Year, Prospective, Multinational, Observational Study, Ravi Savarirayan, Melita Irving, Paul Harmatz, Borja Delgado, William R Wilcox, John Philips, Natalie Owen, Carlos A Bacino, Louise Tofts, Joel Charrow, Lynda E Polgreen, Julie Hoover-Fong, Paul Arundel, Ignacio Ginebreda, Howard M Saal, Donald Basel, Rosendo Ullot Font, Keiichi Ozono, Michael B Bober, Valerie Cormier-Daire, Kim-Hanh Le Quan Sang, Genevieve Baujat, Yasemin Alanay, Frank Rutsch, Daniel Hoernschemeyer, Klaus Mohnike, Hiroshi Mochizuki, Asako Tajima, Yumiko Kotani, David D Weaver, Klane K White, Clare Army, Kevin Larrimore, Keith Gregg, George Jeha, Claire Milligan, Elena Fisheleva, Alice Huntsman-Labed, Jonathan Day

Faculty, Staff and Students Publications

Purpose: This study was undertaken to collect baseline growth parameters in children with achondroplasia who might enroll in interventional trials of vosoritide, and to establish a historical control.

Methods: In this prospective, observational study, participants (≤17 years) underwent a detailed medical history and physical examination and were followed every 3 months until they finished participating in the study by enrolling in an interventional trial or withdrawing.

Results: A total of 363 children were enrolled (28 centers, 8 countries). Mean (SD) follow up was 20.4 (15.0) months. In participants < 1 year, mean annualized growth velocity (AGV) was 11.6 cm/year for girls and 14.6 cm/year for boys. By age 1 year, mean AGV decreased to 7.4 cm/year in girls and 7.1 cm/year in boys. By age 10 years, mean AGV decreased to 3.6 cm/year for both sexes. Mean height z-score in participants < 1 year was -2.5 for girls and -3.2 for boys and decreased up to the age 5 years (-5.3 for girls; -4.6 for boys). Girls and boys had a disproportionate upper-to-lower body segment ratio. Mean ratio was highest in participants aged < 1 year (2.9 for girls; 2.8 for boys) and decreased gradually to approximately 2 in both sexes from 4 years of age onward.

Conclusion: This study represents one of the largest datasets of prospectively collected …

Randomized Placebo-Controlled Trial Of Oral Tannin Supplementation On Covid-19 Symptoms, Gut Dysbiosis And Cytokine Response, Silvia Molino, Andrea Pisarevsky, Shyam Badu, Qinglong Wu, Fabiana López Mingorance, Patricia Vega, Juan Pablo Stefanolo, Julieta Repetti, Guillermina Ludueña, Pablo Pepa, Juan Ignacio Olmos, Marcelo Rodriguez Fermepin, Tatiana Uehara, Elisa Viciani, Andrea Castagnetti, Tor Savidge, María Marta Piskorz

Faculty, Staff and Students Publications

The clinical study aim was to investigate whether a tannin-based dietary supplementation could improve the efficacy of standard-of-care treatment of hospitalized COVID-19 patients by restoring gut microbiota function. Adverse events and immunomodulation post-tannin supplementation were also investigated. A total of 124 patients receiving standard-of-care treatment were randomized to oral tannin-based supplement or placebo for a total of 14 days. Longitudinal blood and stool samples were collected for cytokine and 16S rDNA microbiome profiling, and results were compared with 53 healthy controls. Although oral tannin supplementation did not result in clinical improvement or significant gut microbiome shifts after 14-days, a reduction …

Perfect Polar Alignment Of Parallel Beloamphiphile Monolayers: Synthesis, Characterization, And Crystal Architectures Of Unsymmetrical Phenoxy-Substituted Acetophenone Azines, Harmeet Bhoday, Michael Lewis, Steven P. Kelley, Rainer Glaser

Chemistry Faculty Research & Creative Works

It remains a great challenge to achieve polar order in organic molecular crystals because anti-parallel alignment of side-by-side molecules is intrinsically preferred. We have addressed this problem with a rational design that focuses on the polar stacking of parallel beloamphiphile monolayers (PBAMs) with strong lateral quadrupole-quadrupole attractions. We employ arene-arene interactions as lateral synthons. The first successes were achieved with unsymmetrical donor (X), acceptor (Y) substituted acetophenone azines which form polar PBAMs with double T-contacts between the azines. Near-perfect alignment was achieved with the methoxy series of (MeO, Y)-azines with Y=Cl, Br, I. Here, we report on the synthesis, the …

Wellness And Coping Of Physicians Who Worked In Icus During The Pandemic: A Multicenter Cross-Sectional North American Survey, Karen E. A. Burns, Rachel K. Mcdonald, Et Al.

2020-Current year OA Pubs

OBJECTIVES: Few surveys have focused on physician moral distress, burnout, and professional fulfilment. We assessed physician wellness and coping during the COVID-19 pandemic.

DESIGN: Cross-sectional survey using four validated instruments.

SETTING: Sixty-two sites in Canada and the United States.

SUBJECTS: Attending physicians (adult, pediatric; intensivist, nonintensivist) who worked in North American ICUs.

INTERVENTION: None.

MEASUREMENTS AND MAIN RESULTS: We analysed 431 questionnaires (43.3% response rate) from 25 states and eight provinces. Respondents were predominantly male (229 [55.6%]) and in practice for 11.8 ± 9.8 years. Compared with prepandemic, respondents reported significant intrapandemic increases in days worked/mo, ICU bed occupancy, and …

Building On The Lasting Benefits Of Attending A Voluntary Prekindergarten Program, Ashley Swickle

Dissertations

The expectations of kindergarten students have drastically changed over the years. Kindergarten students who have not attended a voluntary pre-kindergarten (VPK) program may be at a disadvantage in behavior and academics. The purpose of this study is to show the benefits of a VPK program. My study includes kindergarten students at the school under study whose progress monitoring scores in the beginning of the year are compared to student’s scores who have never attended a VPK program, the amount of behavior referrals is also compared. The anticipated results are that kindergarten students who attended VPK will out-perform their peers who …

Mission Possible: Collaborative Practice Promoting Student Success, Danita Smith

Dissertations

Educators working with underserved populations of students seek strategies that promote student engagement and success. Relationship-focused, collaborative practices can provide a framework to promote student success. In this study, I evaluated the program Individualized Student Success Plans used in five charter high schools whose focus was working with underserved students. I surveyed and interviewed administrators, teachers, and support personnel about the implementation practices of the program. This research study yielded recommendations for the effective implementation of a schoolwide initiative to promote active student engagement through positive adult-to-student mentorship.

Identifying Motivations Of New Counselors For Continuing Professional Development Of Multicultural Competencies: A Qualitative Study, Larry English

Dissertations

The need to increase multicultural counseling skills is a crucial area of focus in the continued evolution of the counseling profession. This necessity is due to a number of factors, including the ongoing demographic and societal changes in the United States. The research has helped to bring awareness of the need for increased and continued professional development in the area of cultural literacy and multicultural competencies skills for beginning counselors and others in counseling-related programs. At the micro level, the research investigated new clinicians’ self-awareness of their own biases, assumptions, internalized/externalized actions, and beliefs toward other cultures. The purpose of …

Baseline Microperimetry And Oct In The Rush2a Study: Structure-Function Association And Correlation With Disease Severity, Eleonora M Lad, Jacque L Duncan, Wendi Liang, Maureen G Maguire, Allison R Ayala, Isabelle Audo, David G Birch, Joseph Carroll, Janet K Cheetham, Todd A Durham, Abigail T Fahim, Jessica Loo, Zengtian Deng, Dibyendu Mukherjee, Elise Heon, Robert B Hufnagel, Bin Guan, Alessandro Iannaccone, Glenn J Jaffe, Christine N Kay, Michel Michaelides, Mark E Pennesi, Ajoy Vincent, Christina Y Weng, Sina Farsiu

Faculty, Staff and Students Publications

PURPOSE: To investigate baseline mesopic microperimetry (MP) and spectral domain optical coherence tomography (OCT) in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study.

DESIGN: Natural history study METHODS: Setting: 16 clinical sites in Europe and North AmericaStudy Population: Participants with Usher syndrome type 2 (USH2) (N = 80) or autosomal recessive nonsyndromic RP (ARRP) (N = 47) associated with biallelic disease-causing sequence variants in USH2AObservation Procedures: General linear models were used to assess characteristics including disease duration, MP mean sensitivity and OCT intact ellipsoid zone (EZ) area. The associations between mean sensitivity and EZ area with other measures, …

Evolutionary Cartographies Of Language Diversification: Quantitative Approaches To The Geolinguistic Mapping Of The Kayanic Languages (Central Borneo), Deandré A. Espree-Conaway

Theses and Dissertations

Why are there so many languages in the world and how did this diversity come about? Every day, humans around the world speak over 7,000 languages. One of the most impactful theories describing the processes and mechanisms of language diversification is that of the Linguistic Niche Hypothesis (Lupyan & Dale 2010). The Linguistic Niche Hypothesis suggests that languages adapt to their environments (Lupyan & Dale 2010: 1). Lupyan and Dale describe it, stating that "just as biological organisms are shaped by ecological niches, languages structures...adapt to the environment (niche) in which they are being learned and used" (2010: 1). Taking …

Linguistic Imperialism: A Critical Analysis Of English Hegemony And Its Effect On English Language Learners, Linley King

Honors Theses

This study uses previous research and qualitative data to determine how foreign language teachers can present English to learners as an international communicative tool while also preserving their native L1 identity amidst hegemonic cultural influences. Since becoming a lingua franca, the majority of English users are non-native speakers, and the findings of this study explain how English has globally spread to create distinctive linguistic groups among these speakers and the importance of promoting the equality of their English variations against the “standard” dialect used in current monolingual English language teaching (ELT) policies (Canagarajah, 1999; Duff, 2005; Schmitz, 2014). Responses from …

Examining The Perceived Benefits Of A Career Course For English-Speaking First-Generation Hispanic And Latino Students, David Benjamin Mason

Electronic Theses and Dissertations

The problem that provoked this research is the incessant, declining retention, completion, and transfer rates among English-speaking, first-generation Hispanic and Latino students. Educational institutions continue to increase services, improve academic programs, enhance curriculum design, integrate technology, and consider alternative career paths to success with marginal to no improvement. The purpose of this study was to determine the perceived benefits of English-speaking, first-generation Hispanic and Latino students who participated in a career course instructed by a career professional compared to a course instructed by an academic adjunct faculty member. Developing one’s career remains a vital aspect of the college experience, and …

Assessment Of Veteran Satisfaction With Telehealth Services During The Covid-19 Pandemic, Rhonda Kay Howard

Electronic Theses and Dissertations

Abstract

With the advent of the COVID-19 public health emergency in the United States, many U.S. veterans were unable to maintain their usual office visits due to safe access concerns. Patients were strongly encouraged to maintain their healthcare needs at home by utilizing online technology resources like telehealth services with their healthcare providers. Providing excellent healthcare services for veterans during COVID-19 became a challenge for primary care providers at many veteran healthcare organizations. Since little was known about the satisfaction of veteran clients with healthcare management using virtual care during the pandemic, this formative program evaluation was designed to survey …

Limiting Limited Liability: Requiring More Than Mere Subsequence Under Federal Rule Of Evidence 407, Cynara Hermes Mcquillan

Scholarly Works

Rule 407 of the Federal Rules of Evidence, the “Subsequent Remedial Measures” Rule, is troubling. This exclusionary rule of evidence prohibits using subsequent remedial measures to demonstrate negligence, culpable conduct, or product defect. But, other than in the title of the rule, the phrase “subsequent remedial measures” does not appear anywhere in the rule’s text and the rule itself does not expressly define what measures fall within its purview. This omission creates space for different judicial interpretations of the rule’s language and ultimately disparate judicial outcomes. Although the Federal Rules of Evidence lend themselves to fact-specific inquiries that can lead …

Bonhoeffer: Pacifism And Resistance Revisited With Help From Karl Barth, Roger Newell

Faculty Publications - George Fox School of Theology

This essay will look at some details of Bonhoeffer’s reflections on pacifism and resistance, with special attention to the influence of Karl Barth on his path. I will also look at the implications for our own troubled times as the Church again responds to war in Europe.

Federal Pleading Standards In State Court, Marcus Gadson

Michigan Law Review

Most state courts cannot follow both their state constitutions and federal pleading standards. Even if they could, policy considerations unique to states compel state courts to reject federal pleading standards. This is because federal courts have changed pleading standards to allow judges to make factual determinations on a motion to dismiss and to require more factual detail in complaints. While scholars have vigorously debated whether these changes are wise, just, and permissible under the federal rules and the Constitution, they have ignored the even more important questions of whether state courts can and should adopt those pleading standards. The oversight …

Risk And Reputation, Taylor J. Wilson

Michigan Law Review

Direct listing is an innovative alternative to a traditional initial public offering. Since direct listing was revived in 2018, there have been many lingering questions, particularly about the liability of financial advisors involved in the process. In a traditional IPO, a company retains an investment bank as an underwriter; the underwriter takes on a degree of financial risk and lends credibility to the company’s offering, often directly marketing the offering to potential investors. In a direct listing, however, investment banks act as financial advisors but do not assume financial risk or market the sale of securities. Section 11 is an …

Algorithmic Elections, Sarah M.L. Bender

Michigan Law Review

Artificial intelligence (AI) has entered election administration. Across the country, election officials are beginning to use AI systems to purge voter records, verify mail-in ballots, and draw district lines. Already, these technologies are having a profound effect on voting rights and democratic processes. However, they have received relatively little attention from AI experts, advocates, and policymakers. Scholars have sounded the alarm on a variety of “algorithmic harms” resulting from AI’s use in the criminal justice system, employment, healthcare, and other civil rights domains. Many of these same algorithmic harms manifest in elections and voting but have been underexplored and remain …

Development Of Sustainable, Efficient And Economic Manufacturing Methods For Fabricating Novel Nano-Layered Materials For Multifunctional Applications, Maharshi Dey

Theses and Dissertations

Non-oxide ternary and/or quaternary ceramics called MAX and MAB Phases have attracted a lot of interest in the recent years due to their remarkable properties like damage tolerance, and triboactive behavior as compared to their binary counterparts. These properties make these materials a strong candidate for several high temperature, hypersonic and structural applications. A wide variety of compounds including Cr2AlC and MoAlB, belonging to the same class of materials, have also been reported over the last few decades. These materials have been used as bulk materials, reinforcements and matrices for different composites and coatings on different substrates, apart from different …

Perceptions And Identities Of Adolescent Reader: A Mini Ethnographic Case Study, Rebecca Rose Johnson

Theses and Dissertations

This research explored ways in which educators can provide learners with differentiated instruction through student choice that provides engagement to positively interact with a student’s reading identity. Throughout their learning journey, learners may have both positive and negative experiences with reading that directly affect their reading identity. Students need support and guidance through multiple learning opportunities of choice in their reading and making positives connections with literature while reaching set learning objectives.In this dissertation, relevant literature was reviewed, investigating the benefits of student choice in reading and the effects that choice has on a student’s reading identity. The primary goals …

Factors That Influence School Nurses' Intent To Report Child Maltreatment, Catherine M. Jordan

Theses and Dissertations

Introduction: Child maltreatment is a global problem that causes harm to the well-being of a child that extends to adulthood. In the United States alone, there are 158,900 child victims in 2019 and 1,779 child fatalities. Despite national attention and the availability of child abuse education, the victimization statistics have remained essentially unchanged in the last 11 years. Nurses are mandated reporters of child maltreatment. School nurses are frequent observers in a child’s life, thus leaving them uniquely qualified for real-time assessment. The purpose of this study is to determine what factors correlate with the school nurse’s intent to report …

A Cross-Sectional Exploratory Study On Voluntary Reporting Of Professional Groups In U.S. Commercial Aviation, James Norman

Theses and Dissertations

Aviation safety culture research does not exist regarding the specific factors that either promote or discourage voluntary safety reporting among different frontline groups in U.S. Part 121 operations. Moreover, while safety culture has been shown to vary across workgroups, cross-sectional research across multiple aviation organizations regarding voluntary reporting is lacking. To address this gap in the literature, an exploratory study was conducted utilizing a sequential, confirmatory mixed methods approach. A 28-item survey was distributed to air traffic controllers, dispatchers, maintenance technicians, and pilots. The instrument quantitatively assessed organizational safety values, reporting friction, previous reporting experience, just culture, and voluntary reporting …

Willow, Abuelo, & Me, Robin Jewel Smith

Theses and Dissertations

My dissertation, Willow, Abuelo & Me is a collection of 50 poems that interrogates the site of deep childhood sexual trauma that I experienced when I was five years old at the hands of my step-grandfather, and the consequences of that trauma on my adult life. This collection has several strands woven together in order to come to understand and relay this trauma. The first strand is a poetic retelling of dark Germanic fairy tales where children are often put through tests by their abusive caretakers. The second being “breaks” from the darkness or moments of brevity and light to …

Indigenizing The Outbreak Narrative: How Lee Maracle, Richard Van Camp, And Cherie Dimaline Critique Settler Colonialism And Medical Racism, Deanne Michelle Sparks

Theses and Dissertations

The dissertation analyzes how Lee Maracle's Ravensong, Richard Van Camp's "I Am Filled with a Trembling Heart", and Cherie Dimaline's The Marrow Thieves critique the traditional outbreak narrative structures identified by Charles Rosenberg and Priscilla Wald. Specifically, these Indigenous texts decenter the microbe for a more miasmic perspective that takes into consideration how settler colonialism and medical racism complicates the disease experience and its social epidemic.

Γ-Ray Emission From Classical Nova V392 Per: Measurements From Fermi And Hawc, A. Albert, R. Alfaro, C. Alvarez, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A.Ayala Solares, R. Babu, E. Belmont-Moreno, C. Blochwitz, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, O. Chaparro-Amaro, U. Cotti, J. Cotzomi, E. De La Fuente, C. De León, S. Coutino De Leon, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, M. Durocher, J. C. Diaz-Velez, K. Engel, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, M. M. Gonzalez, J. A. Goodman, J. P. Harding, S. Hernandez, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, V. Joshi, A. Lara, W. H. Lee, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, J. Lundeen, K. Malone, V. Marandon, O. Martinez, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, M. Newbold, M. U. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, D. Salazar-Gallegos, F. Salesa Greus, A. Sandoval, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, L. Villasenor, Xiaojie Wang, E. Willox, A. Zepeda, H. Zhou, L. Chomiuk, E. Aydi, K. L. Li, B. D. Metzgar, I. Vurm

Physics Faculty Research & Creative Works

This paper reports on the γ-ray properties of the 2018 Galactic nova V392 Per, spanning photon energies ∼0.1 GeV-100 TeV by combining observations from the Fermi Gamma-ray Space Telescope and the HAWC Observatory. As one of the most rapidly evolving γ-ray signals yet observed for a nova, GeV γ-rays with a power-law spectrum with an index Γ = 2.0 ± 0.1 were detected over 8 days following V392 Per's optical maximum. HAWC observations constrain the TeV γ-ray signal during this time and also before and after. We observe no statistically significant evidence of TeV γ-ray emission from V392 Per, but …