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Understanding Ecological Relationships To Improve Biofouling Management Practices In The Marine Environment, Ann Catherine Wassick Dec 2022

Understanding Ecological Relationships To Improve Biofouling Management Practices In The Marine Environment, Ann Catherine Wassick

Theses and Dissertations

Biofouling, the growth of benthic invertebrates on anthropogenic surfaces, impacts many industries and is a major vector of non-native species worldwide. Understanding the ecological relationships between biofouling organisms and their environment is necessary to assist management practices. This study investigates the biofouling communities at Port Canaveral, Florida, in order to potentially refine biofouling mitigation practices. Recruitment panels were used to document the temporal changes in community composition, biofouling pressure, recruitment, and growth rates. These factors were also used to assess relationships with temperature and salinity. A second component of this work provided documentation on the variation in non-native species abundance …


The Relationship Between Hallucinations And Visuospatial Impairment Among Individuals With Dementia, Ruta Sohoni Dec 2022

The Relationship Between Hallucinations And Visuospatial Impairment Among Individuals With Dementia, Ruta Sohoni

Theses and Dissertations

Objective: This study examines the neuropsychological functioning, specifically using the Hooper Visual Organization Test (VOT), to understand the impact of hallucinations on the level of impairment in the visuospatial domain.

Method: Archival data obtained over three years from a total of 73 patients from the Health First Memory Disorder Clinic was used in this study. Participants were included in the study if they endorsed experiencing hallucinations, were given the VOT during their brief neuropsychological evaluation, and were diagnosed with dementia or unspecified neurocognitive disorder. The patient’s electronic medical record was used to retrospectively gather additional details regarding their hallucinations and …


Call The Doctor! A Study Of Parental Medical Nonadherence Within Child Custody Proceedings, Karissa Lynn Cummons Dec 2022

Call The Doctor! A Study Of Parental Medical Nonadherence Within Child Custody Proceedings, Karissa Lynn Cummons

Theses and Dissertations

Medical nonadherence is a common and formidable problem that many pediatric healthcare providers face when treating children with acute and chronic medical conditions because adhering to a physicians’ treatment recommendations is beneficial for successful treatment, disease prevention, and healthy promotion (Dawood et al., 2010). It was estimated that at least one third of patients are unable to complete or adhere to relatively short treatment regimens (Dawood et al., 2010). Reasons for nonadherence to a physicians’ recommendations range from extended duration of treatment, multiple prescribed medications, and periods of symptom remission (Dawood et al., 2010). Despite a parent’s or family’s reason …


The Uncertainty And Psychological Health Of Family Caregivers Of Patients With Delirium In Intensive Care Units, Amal Shokri Haji Assa Dec 2022

The Uncertainty And Psychological Health Of Family Caregivers Of Patients With Delirium In Intensive Care Units, Amal Shokri Haji Assa

Theses and Dissertations (ETD)

Each year, more than 5 million patients are admitted to an intensive care unit (ICU) in the United States, and up to 80 % of these patients develop delirium. Delirium is a common indicator of acute brain dysfunction in the ICU and a predictor of mortality, longer ICU/hospital stay, and long-term cognitive impairment. Family caregivers are a valuable resource in preventing, detecting, and managing delirium in the ICU. However, witnessing delirium episodes can generate adverse psychological symptoms in family caregivers that may compromise their health and well-being. Research in this area has demonstrated a gap in the literature regarding how …


"The Lady Took Me To The End Of The World!": The Life Of Mrs. N.A. Courtright., Marcus Walker Dec 2022

"The Lady Took Me To The End Of The World!": The Life Of Mrs. N.A. Courtright., Marcus Walker

Faculty and Staff Scholarship

Nellie Almee Courtright was the first female to earn a law degree from the University of Louisville School of Law, but she had an accomplished career before -- and even after -- she stepped foot into a law classroom. This is the account of a woman who made her own way in the world, and made life better for hundreds in doing so.


Wellness And Coping Of Physicians Who Worked In Icus During The Pandemic: A Multicenter Cross-Sectional North American Survey, Karen E. A. Burns, Rachel K. Mcdonald, Et Al. Dec 2022

Wellness And Coping Of Physicians Who Worked In Icus During The Pandemic: A Multicenter Cross-Sectional North American Survey, Karen E. A. Burns, Rachel K. Mcdonald, Et Al.

2020-Current year OA Pubs

OBJECTIVES: Few surveys have focused on physician moral distress, burnout, and professional fulfilment. We assessed physician wellness and coping during the COVID-19 pandemic.

DESIGN: Cross-sectional survey using four validated instruments.

SETTING: Sixty-two sites in Canada and the United States.

SUBJECTS: Attending physicians (adult, pediatric; intensivist, nonintensivist) who worked in North American ICUs.

INTERVENTION: None.

MEASUREMENTS AND MAIN RESULTS: We analysed 431 questionnaires (43.3% response rate) from 25 states and eight provinces. Respondents were predominantly male (229 [55.6%]) and in practice for 11.8 ± 9.8 years. Compared with prepandemic, respondents reported significant intrapandemic increases in days worked/mo, ICU bed occupancy, and …


Examining The Perceived Benefits Of A Career Course For English-Speaking First-Generation Hispanic And Latino Students, David Benjamin Mason Dec 2022

Examining The Perceived Benefits Of A Career Course For English-Speaking First-Generation Hispanic And Latino Students, David Benjamin Mason

Electronic Theses and Dissertations

The problem that provoked this research is the incessant, declining retention, completion, and transfer rates among English-speaking, first-generation Hispanic and Latino students. Educational institutions continue to increase services, improve academic programs, enhance curriculum design, integrate technology, and consider alternative career paths to success with marginal to no improvement. The purpose of this study was to determine the perceived benefits of English-speaking, first-generation Hispanic and Latino students who participated in a career course instructed by a career professional compared to a course instructed by an academic adjunct faculty member. Developing one’s career remains a vital aspect of the college experience, and …


Assessment Of Veteran Satisfaction With Telehealth Services During The Covid-19 Pandemic, Rhonda Kay Howard Dec 2022

Assessment Of Veteran Satisfaction With Telehealth Services During The Covid-19 Pandemic, Rhonda Kay Howard

Electronic Theses and Dissertations

Abstract

With the advent of the COVID-19 public health emergency in the United States, many U.S. veterans were unable to maintain their usual office visits due to safe access concerns. Patients were strongly encouraged to maintain their healthcare needs at home by utilizing online technology resources like telehealth services with their healthcare providers. Providing excellent healthcare services for veterans during COVID-19 became a challenge for primary care providers at many veteran healthcare organizations. Since little was known about the satisfaction of veteran clients with healthcare management using virtual care during the pandemic, this formative program evaluation was designed to survey …


Loss Of Wnt4 In The Gubernaculum Causes Unilateral Cryptorchidism And Fertility Defects, Abhishek Seth, Juan C Bournat, Olga Medina-Martinez, Armando Rivera, Joshua Moore, Hunter Flores, Jill A Rosenfeld, Liya Hu, Carolina J Jorgez Dec 2022

Loss Of Wnt4 In The Gubernaculum Causes Unilateral Cryptorchidism And Fertility Defects, Abhishek Seth, Juan C Bournat, Olga Medina-Martinez, Armando Rivera, Joshua Moore, Hunter Flores, Jill A Rosenfeld, Liya Hu, Carolina J Jorgez

Faculty, Staff and Students Publications

Undescended testis (UDT) affects 6% of male births. Despite surgical correction, some men with unilateral UDT may experience infertility with the contralateral descended testis (CDT) showing no A-dark spermatogonia. To improve our understanding of the etiology of infertility in UDT, we generated a novel murine model of left unilateral UDT. Gubernaculum-specific Wnt4 knockout (KO) mice (Wnt4-cKO) were generated using retinoic acid receptor β2-cre mice and were found to have a smaller left-unilateral UDT. Wnt4-cKO mice with abdominal UDT had an increase in serum follicle-stimulating hormone and luteinizing hormone and an absence of germ cells in the undescended testicle. Wnt4-cKO mice …


Human Loss-Of-Function Variants In The Serotonin 2c Receptor Associated With Obesity And Maladaptive Behavior, Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes De Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi Dec 2022

Human Loss-Of-Function Variants In The Serotonin 2c Receptor Associated With Obesity And Maladaptive Behavior, Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes De Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi

Children’s Nutrition Research Center Staff Publications

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT2CR (HTR2C) in 19 unrelated people (3 males and 16 females). Eleven variants caused a loss of function in HEK293 cells. All people who carried variants had hyperphagia and some degree of maladaptive behavior. Knock-in male mice harboring a human loss-of-function HTR2C variant developed …


Propranolol Modulates Cerebellar Circuit Activity And Reduces Tremor., Joy Zhou, Meike E Van Der Heijden, Luis E Salazar Leon, Tao Lin, Lauren N Miterko, Dominic J Kizek, Ross M Perez, Matea Pavešković, Amanda M Brown, Roy V Sillitoe Dec 2022

Propranolol Modulates Cerebellar Circuit Activity And Reduces Tremor., Joy Zhou, Meike E Van Der Heijden, Luis E Salazar Leon, Tao Lin, Lauren N Miterko, Dominic J Kizek, Ross M Perez, Matea Pavešković, Amanda M Brown, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Tremor is the most common movement disorder. Several drugs reduce tremor severity, but no cures are available. Propranolol, a β-adrenergic receptor blocker, is the leading treatment for tremor. However, the in vivo circuit mechanisms by which propranolol decreases tremor remain unclear. Here, we test whether propranolol modulates activity in the cerebellum, a key node in the tremor network. We investigated the effects of propranolol in healthy control mice and Car8wdl/wdl mice, which exhibit pathophysiological tremor and ataxia due to cerebellar dysfunction. Propranolol reduced physiological tremor in control mice and reduced pathophysiological tremor in Car8wdl/wdl mice to control levels. …


Clinical And Demographic Factors Contributing To Asparaginase-Associated Toxicities In Children With Acute Lymphoblastic Leukemia, Priyadarshani Dharia, Michael D Swartz, M Brooke Bernhardt, Han Chen, M Monica Gramatges, Philip J Lupo, Austin L Brown, Michael E Scheurer Dec 2022

Clinical And Demographic Factors Contributing To Asparaginase-Associated Toxicities In Children With Acute Lymphoblastic Leukemia, Priyadarshani Dharia, Michael D Swartz, M Brooke Bernhardt, Han Chen, M Monica Gramatges, Philip J Lupo, Austin L Brown, Michael E Scheurer

Center for Medical Ethics and Health Policy Staff Publications

A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3%). Odds ratios (OR) and 95% confidence intervals (CI) evaluated associations between clinical factors and each toxicity, cumulative number of toxicities, and toxicity clusters identified using k-mode analysis. Most (68.9%) did not experience any toxicity, 24.6% experienced one toxicity, and 6.3% two or more. Age >10 years was associated with hyperbilirubinemia (OR = 3.83; 95% CI: 1.64-8.95), pancreatitis (OR = 3.72; 95% CI: 1.29-10.68), VTE (OR = 4.65; …


Germline Genetic And Treatment-Related Risk Factors For Diabetes Mellitus In Survivors Of Childhood Cancer: A Report From The Childhood Cancer Survivor Study And St Jude Lifetime Cohorts, Melissa A Richard, Sogol Mostoufi-Moab, Nisha Rathore, Jessica Baedke, Austin L Brown, Stephen J Chanock, Danielle N Friedman, M Monica Gramatges, Rebecca M Howell, Kala Y Kamdar, Wendy M Leisenring, Lillian R Meacham, Lindsay M Morton, Kevin Oeffinger, Leslie L Robison, Yadav Sapkota, Charles A Sklar, Gregory T Armstrong, Smita Bhatia, Philip J Lupo Dec 2022

Germline Genetic And Treatment-Related Risk Factors For Diabetes Mellitus In Survivors Of Childhood Cancer: A Report From The Childhood Cancer Survivor Study And St Jude Lifetime Cohorts, Melissa A Richard, Sogol Mostoufi-Moab, Nisha Rathore, Jessica Baedke, Austin L Brown, Stephen J Chanock, Danielle N Friedman, M Monica Gramatges, Rebecca M Howell, Kala Y Kamdar, Wendy M Leisenring, Lillian R Meacham, Lindsay M Morton, Kevin Oeffinger, Leslie L Robison, Yadav Sapkota, Charles A Sklar, Gregory T Armstrong, Smita Bhatia, Philip J Lupo

Center for Medical Ethics and Health Policy Staff Publications

Purpose: To characterize germline genetic risk factors of diabetes mellitus among long-term survivors of childhood cancer.

Methods: Adult survivors of childhood cancer from the Childhood Cancer Survivor Study (CCSS) Original Cohort (n = 5,083; 383 with diabetes) were used to conduct a discovery genome-wide association study. Replication was performed using the CCSS Expansion (n = 2,588; 40 with diabetes) and the St Jude Lifetime (SJLIFE; n = 3,351; 208 with diabetes) cohorts. Risk prediction models, stratified on exposure to abdominal radiation, were calculated using logistic regression including attained age, sex and body mass index, diagnosis, alkylating chemotherapy, age at cancer …


Prenatal Phenotyping Of Fetal Tubulinopathies: A Multicenter Retrospective Case Series, Bobby K Brar, Marisa Gilstrop Thompson, Neeta L Vora, Kelly Gilmore, Karin Blakemore, Kristen A Miller, Jessica Giordano, Andreas Dufke, Beatrix Wong, Samantha Stover, Billie Lianoglou, Ignatia Van Den Veyver, Esther Dempsey, Mara Rosner, Karen Chong, David Chitayat, Teresa N Sparks, Mary E Norton, Ronald Wapner, Kristin Baranano, Angie C Jelin, Fetal Sequencing Consortium Dec 2022

Prenatal Phenotyping Of Fetal Tubulinopathies: A Multicenter Retrospective Case Series, Bobby K Brar, Marisa Gilstrop Thompson, Neeta L Vora, Kelly Gilmore, Karin Blakemore, Kristen A Miller, Jessica Giordano, Andreas Dufke, Beatrix Wong, Samantha Stover, Billie Lianoglou, Ignatia Van Den Veyver, Esther Dempsey, Mara Rosner, Karen Chong, David Chitayat, Teresa N Sparks, Mary E Norton, Ronald Wapner, Kristin Baranano, Angie C Jelin, Fetal Sequencing Consortium

Center for Medical Ethics and Health Policy Staff Publications

Objective: Tubulinopathies refer to conditions caused by genetic variants in isotypes of tubulin resulting in defective neuronal migration. Historically, diagnosis was primarily via postnatal imaging. Our objective was to establish the prenatal phenotype/genotype correlations of tubulinopathies identified by fetal imaging.

Methods: A large, multicenter retrospective case series was performed across nine institutions in the Fetal Sequencing Consortium. Demographics, fetal imaging reports, genetic screening and diagnostic testing results, delivery reports, and neonatal imaging reports were extracted for pregnancies with a confirmed molecular diagnosis of a tubulinopathy.

Results: Nineteen pregnancies with a fetal tubulinopathy were identified. The most common prenatal imaging findings …


Effect Of Problem-Solving Treatment On Self-Reported Disability Among Veterans With Gulf War Illness: A Randomized Clinical Trial, Lisa M Mcandrew, Karen S Quigley, Shou-En Lu, David Litke, Joseph F Rath, Gudrun Lange, Susan L Santos, Nicole Anastasides, Beth Ann Petrakis, Lauren Greenberg, Drew A Helmer, Wilfred R Pigeon Dec 2022

Effect Of Problem-Solving Treatment On Self-Reported Disability Among Veterans With Gulf War Illness: A Randomized Clinical Trial, Lisa M Mcandrew, Karen S Quigley, Shou-En Lu, David Litke, Joseph F Rath, Gudrun Lange, Susan L Santos, Nicole Anastasides, Beth Ann Petrakis, Lauren Greenberg, Drew A Helmer, Wilfred R Pigeon

Center for Medical Ethics and Health Policy Staff Publications

Importance: Few evidence-based treatments are available for Gulf War illness (GWI). Behavioral treatments that target factors known to maintain the disability from GWI, such as problem-solving impairment, may be beneficial. Problem-solving treatment (PST) targets problem-solving impairment and is an evidence-based treatment for other conditions.

Objective: To examine the efficacy of PST to reduce disability, problem-solving impairment, and physical symptoms in GWI.

Design, setting, and participants: This multicenter randomized clinical trial conducted in the US Department of Veterans Affairs compared PST with health education in a volunteer sample of 511 Gulf War veterans with GWI and disability (January 1, 2015, to …


Simultaneous Use Of Endobronchial And Endoscopic Ultrasound Guidance As Primary Tools In The Diagnosis Of Malignant Pleural Mesothelioma, Babith Mankidy, Jordan Sparkman, Shreyes Boddu, Quillann Huang, Munish Sharma Dec 2022

Simultaneous Use Of Endobronchial And Endoscopic Ultrasound Guidance As Primary Tools In The Diagnosis Of Malignant Pleural Mesothelioma, Babith Mankidy, Jordan Sparkman, Shreyes Boddu, Quillann Huang, Munish Sharma

Faculty, Staff and Students Publications

Malignant pleural mesothelioma (MPM) is related to exposure to asbestos. It is insidious in nature and is generally diagnosed at an advanced stage. MPM is aggressive and portends a poor prognosis. Definitive diagnosis is usually established by obtaining pathological samples of the pleura by medical or surgical thoracoscopy. However, these procedures are invasive and carry a risk of seeding of biopsy sites with tumors. We herein report an infrequently encountered case of simultaneous use of endobronchial ultrasound and endoscopic ultrasound-guided biopsy of malignant pleural mesothelioma in a 48-year-old female patient.


A Systematic Scoping Review Of Faropenem And Other Oral Penems: Treatment Of Enterobacterales Infections, Development Of Resistance And Cross-Resistance To Carbapenems, Sumanth Gandra, Satoshi Takahashi, Fanny S Mitrani-Gold, Aruni Mulgirigama, Diogo A Ferrinho Dec 2022

A Systematic Scoping Review Of Faropenem And Other Oral Penems: Treatment Of Enterobacterales Infections, Development Of Resistance And Cross-Resistance To Carbapenems, Sumanth Gandra, Satoshi Takahashi, Fanny S Mitrani-Gold, Aruni Mulgirigama, Diogo A Ferrinho

2020-Current year OA Pubs

BACKGROUND: Antimicrobial resistance is an urgent global healthcare concern. Beyond carbapenems as broad-spectrum, often 'last resort' antibiotics, oral penem antibiotics currently are approved only in Japan and India, used for the treatment of indications including urinary tract infections (UTIs). Exploring oral penem use to better understand the impact of antibiotic resistance on public health would help inform the management of infectious diseases, including UTIs.

SCOPING REVIEW METHODOLOGY: This scoping review investigated the impact of faropenem and other oral penems on Enterobacterales infection treatment and evaluated evidence for faropenem resistance and cross-resistance to carbapenems. PubMed, Embase, J-STAGE and CiNii were searched …


Better-Than-Chance Prediction Of Cooperative Behaviour From First And Second Impressions, Eric Schniter, Timothy W. Shields Dec 2022

Better-Than-Chance Prediction Of Cooperative Behaviour From First And Second Impressions, Eric Schniter, Timothy W. Shields

ESI Working Papers

Could cooperation among strangers be facilitated by adaptations that use sparse information to accurately predict cooperative behaviour? We hypothesize that predictions are influenced by beliefs, descriptions, appearance, and behavioural history available for first and second impressions. We also hypothesize that predictions improve when more information is available. We conducted a two-part study. First, we recorded thin-slice videos of university students just before their choices in a repeated Prisoner’s Dilemma with matched partners. Second, a worldwide sample of raters evaluated each player using either videos, photos, only gender labels, or neither images nor labels. Raters guessed players’ first-round Prisoner’s Dilemma choices …


Support-Seeking By Cancer Caregivers Living In Rural Australia, Elizabeth A. Johnston, Belinda C. Goodwin, Larry Myers, Sonja March, Joanne F. Aitken, Suzanne K. Chambers, Jeff Dunn Dec 2022

Support-Seeking By Cancer Caregivers Living In Rural Australia, Elizabeth A. Johnston, Belinda C. Goodwin, Larry Myers, Sonja March, Joanne F. Aitken, Suzanne K. Chambers, Jeff Dunn

Research outputs 2022 to 2026

Objective: Rural cancer caregivers report poor wellbeing and high unmet needs for support. This study investigates sources of support sought by cancer caregivers living in rural Australia, and factors associated with support-seeking. Methods: Informal caregivers of people with cancer completed a questionnaire assessing sociodemographic characteristics, caregiver factors and support-seeking. Descriptive statistics, bivariate analyses and logistic regression were used to identify common sources of support and factors associated with support-seeking. Alluvial and radar plots were used to identify and describe support-seeking profiles. Findings: Of 244 rural caregivers, 64 % reported seeking support for themselves, 72 % for the cancer patient, and …


Psychedelic Forum Member Preferences For Carer Experience And Consumption Behavior: Can “Trip Sitters” Help Inform Psychedelic Harm Reduction Services?, Liam B. Engel, Sascha B. Thal, Stephen J. Bright Dec 2022

Psychedelic Forum Member Preferences For Carer Experience And Consumption Behavior: Can “Trip Sitters” Help Inform Psychedelic Harm Reduction Services?, Liam B. Engel, Sascha B. Thal, Stephen J. Bright

Research outputs 2022 to 2026

Background: There is limited research on the provision of harm reduction services to people who use psychedelics. Little is known about provision of care to people consuming psychedelics outside of clinical trials.

Methods: We investigated how people who used psychedelics discussed their preferences for care (or “trip sitting”) on two online forums: The Shroomery and DMT Nexus. A thematic analysis of the discussion was conducted to better understand consumer preferences for harm reduction services and resources.

Conclusion: Demand for trip sitters with lived psychedelic experience is likely influenced by stigma and empathy. Trip sitters who could relate to the effects …


Research Methodology In Acupuncture And Moxibustion For Managing Primary Dysmenorrhea: A Scoping Review, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang Dec 2022

Research Methodology In Acupuncture And Moxibustion For Managing Primary Dysmenorrhea: A Scoping Review, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang

Research outputs 2022 to 2026

Background: Acupuncture and moxibustion have promising effects in managing primary dysmenorrhea. However, some evidence from clinical trials remains controversial due to methodological flaws in study designs that involve acupuncture and its related modalities and require urgent attention and dialogue. Methods: Allied and Complementary Medicine Database (AMED), Cochrane Library, Excerpta Medica database (EMBASE), PubMed, Web of Sciences, Chinese Biological Medicine (CBM), China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), and Wanfang database were searched from their inception to July 2021. Data were extracted based on the types of study design, primary outcome measures, adverse events (AEs), and …


Prevalence Of Distress And Its Associated Factors Among Caregivers Of People Diagnosed With Cancer: A Cross-Sectional Study, Deborah L. Kirk, Istvan Kabdebo, Lisa Whitehead Dec 2022

Prevalence Of Distress And Its Associated Factors Among Caregivers Of People Diagnosed With Cancer: A Cross-Sectional Study, Deborah L. Kirk, Istvan Kabdebo, Lisa Whitehead

Research outputs 2022 to 2026

Aims and Objectives: To (i) determine prevalence of distress among caregivers of people living with cancer, (ii) describe caregivers’ most commonly reported problems and (iii) investigate which factors were associated with caregivers’ distress. Background: The psychological distress associated with a cancer diagnosis jointly impacts those living with cancer and their caregivers(s). As the provision of clinical support moves towards a dyadic model, understanding the factors associated with caregivers’ distress is increasingly important. Design: Cross-sectional study. Methods: Distress screening data were analysed for 956 caregivers (family and friends) of cancer patients accessing the Cancer Council Western Australia information and support line …


Efficacy And Safety Of Lifileucel, A One-Time Autologous Tumor-Infiltrating Lymphocyte (Til) Cell Therapy, In Patients With Advanced Melanoma After Progression On Immune Checkpoint Inhibitors And Targeted Therapies: Pooled Analysis Of Consecutive Cohorts Of The C-144-01 Study, Jason Chesney, Karl D Lewis, Harriet Kluger, Omid Hamid, Eric Whitman, Sajeve Thomas, Martin Wermke, Mike Cusnir, Evidio Domingo-Musibay, Giao Q Phan, John M Kirkwood, Jessica C Hassel, Marlana Orloff, James Larkin, Jeffrey Weber, Andrew J S Furness, Nikhil I Khushalani, Theresa Medina, Michael E Egger, Friedrich Graf Finckenstein, Madan Jagasia, Parameswaran Hari, Giri Sulur, Wen Shi, Xiao Wu, Amod Sarnaik Dec 2022

Efficacy And Safety Of Lifileucel, A One-Time Autologous Tumor-Infiltrating Lymphocyte (Til) Cell Therapy, In Patients With Advanced Melanoma After Progression On Immune Checkpoint Inhibitors And Targeted Therapies: Pooled Analysis Of Consecutive Cohorts Of The C-144-01 Study, Jason Chesney, Karl D Lewis, Harriet Kluger, Omid Hamid, Eric Whitman, Sajeve Thomas, Martin Wermke, Mike Cusnir, Evidio Domingo-Musibay, Giao Q Phan, John M Kirkwood, Jessica C Hassel, Marlana Orloff, James Larkin, Jeffrey Weber, Andrew J S Furness, Nikhil I Khushalani, Theresa Medina, Michael E Egger, Friedrich Graf Finckenstein, Madan Jagasia, Parameswaran Hari, Giri Sulur, Wen Shi, Xiao Wu, Amod Sarnaik

Department of Medical Oncology Faculty Papers

Background: Patients with advanced melanoma have limited treatment options after progression on immune checkpoint inhibitors (ICI). Lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, demonstrated an investigator-assessed objective response rate (ORR) of 36% in 66 patients who progressed after ICI and targeted therapy. Herein, we report independent review committee (IRC)-assessed outcomes of 153 patients treated with lifileucel in a large multicenter Phase 2 cell therapy trial in melanoma.

Methods: Eligible patients had advanced melanoma that progressed after ICI and targeted therapy, where appropriate. Melanoma lesions were resected (resected tumor diameter ≥1.5 cm) and shipped to a central good manufacturing …


A Thematic Analysis Of Resilient Experiences Of People Who Use Drugs And Are Living With Hiv Adhering To Hiv Medicine, Valeria Duenas Dec 2022

A Thematic Analysis Of Resilient Experiences Of People Who Use Drugs And Are Living With Hiv Adhering To Hiv Medicine, Valeria Duenas

Open Access Theses & Dissertations

Human immunodeficiency virus (HIV) is a disease acquired through sex, from mother to child, sharing needles, and open wound exposure to the blood-borne virus. The disease leads to the rapid weakening of the immune system which renders the individual vulnerable to various opportunistic infections, cancer, disease progression into acquired immunodeficiency virus (AIDS), and possibly death. Unfortunately, US Latinos are disproportionately affected by HIV as they account for nearly 30% of all new HIV infections. A subpopulation disproportionately affected also are people who inject drugs (PWID) which account for 1 in 10 HIV diagnosis in the U.S. Modern medicine has allowed …


Using Culturally Responsive Teaching And Funds Of Knowledge To Engage Culturally And Linguistically Diverse Students In Authentic Learning, Marybelle Gonzales Dec 2022

Using Culturally Responsive Teaching And Funds Of Knowledge To Engage Culturally And Linguistically Diverse Students In Authentic Learning, Marybelle Gonzales

Open Access Theses & Dissertations

ABSTRACT

This study employed the theoretical frameworks of Culturally Responsive Teaching and Funds of Knowledge as lens for understanding how English as a Second Language (ESL) teachers in the Texas border region use culturally responsive teaching and funds of knowledge to engage culturally diverse students in authentic learning. The results of this study include the following themes: Curriculum, instruction and assessment of culturally and linguistically diverse students; lessons learned from virtual/online teaching and learning during the COVID-19 pandemic; culturally responsive teaching practices; funds of knowledge; and authentic learning. The results indicated that while English as a Second Language (ESL) in …


No Better Than Any: An Exploration Of Masculinity And Modes Of Violence, Brian Daniel Lee Dec 2022

No Better Than Any: An Exploration Of Masculinity And Modes Of Violence, Brian Daniel Lee

Open Access Theses & Dissertations

In these seventeen short stories, I attempt to elicit and unmask hegemonic structures for what they are: destructive, dehumanizing, and unnatural. In these stories, I have positioned seemingly benevolent or at least nonviolent male and female protagonists in worlds somewhat removed, but not foreign from our own. The stories are intended to convey a sort of bathetic majority response to the destructive forces at work in society. The purpose for these settings and largely nonplussed characters is to better trace the fault lines of the masculine hegemonic structures and to pull symbolic and systemic violence into an atmosphere where it …


Faculty Experiences Teaching In An Mba Program In The Context Of Covid-19 A Sensemaking Approach, Jesus Rolando Nuñez Dec 2022

Faculty Experiences Teaching In An Mba Program In The Context Of Covid-19 A Sensemaking Approach, Jesus Rolando Nuñez

Open Access Theses & Dissertations

The Sensemaking framework is often utilized when disruptive events create ambiguity and force individuals to make sense of things differently, personally and professionally, by "structuring the unknown" (Waterman, 1990, p.41). By way of example, the COVID-19 pandemic was a significant disruptor to the education sector. Institutional decisions driven by the initial crisis kept daily functions and the educational process moving forward in 2020 by faculty members leveraging existing technology to continue teaching their students. The pandemic disrupted the daily routine of brick-and-mortar operations and many institutions' face-to-face delivery of academic content. The implications of the pandemic forced every faculty member …


Rhetorical Conversations: Race, Class, And Gender In The Works Of Jacqueline Jones Royster And Shirley Wilson Logan, Tanya Robertson Dec 2022

Rhetorical Conversations: Race, Class, And Gender In The Works Of Jacqueline Jones Royster And Shirley Wilson Logan, Tanya Robertson

Open Access Theses & Dissertations

This project is an examination of Jacqueline Jones Royster and Shirley Wilson Logan as knowledge-makers in the field of rhetoric and composition. There is a large gap in research on the contemporary African American women scholars who act as knowledge makers of rhetorical theory and rhetorical pedagogy. There is circularity in the notion that as Royster and Logan examine the history of the fieldâ??African American rhetorical practices, feministic rhetorical practices, English language studies and literacy, and classroom practicesâ??they are, themselves, having an impact on the field.


Vatra: A Poetic Memoir, Ashley Nichole Stevens Dec 2022

Vatra: A Poetic Memoir, Ashley Nichole Stevens

Open Access Theses & Dissertations

When I initially began researching for and composing this collection, the idea I had in mind was a simple one: tell my great grandfather's story, on many Lemko-American immigrants lived in the early 1900s. However, it took several months for me to realize this was not the complete story. It required refinement. While I had always felt a significant connection to this particular side of my family, I could never articulate why. The genealogical and historical research I conducted spoke for me. My great grandfather survived numerous traumas associated with being an ethnic minority in his homeland as well as …


Teachers' Perspectives On Decolonizing U.S. Curriculum For Latinx Through Ethnic Studies Programs At The Middle And High School Levels, Richard Varela Dec 2022

Teachers' Perspectives On Decolonizing U.S. Curriculum For Latinx Through Ethnic Studies Programs At The Middle And High School Levels, Richard Varela

Open Access Theses & Dissertations

The purpose of this study was to understand the implementation of an ethnic studies program with an emphasis on Mexican American Studies at the middle and high school level, in a district located along the Mexican/U.S. frontera. Ethnic Studies are a critical, interdisciplinary academic field of study that acknowledges that race, and racism are embedded in every U.S. system, especially our educational institution. As a critical pedagogy, ethnic studies validate and encourages the voices and viewpoints of the marginalized, while analyzing and criticizing dominant influences that promote â??normalizingâ?? of racialized inequality (de los Rios, 2013). At the center of ethnic …