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On The Bookshelf And Streaming, Susan Dumais

UNH Today Archive

No abstract provided.

A Flexible-Hazards Cure Model With Application To Patients With Soft Tissue Sarcoma, Can Xie, Xuelin Huang, Ruosha Li, Peter W T Pisters

Faculty, Staff and Student Publications

In medical research, it is often of great interest to have an accurate estimation of cure rates by different treatment options and for different patient groups. If the follow-up time is sufficiently long and the sample size is large, the proportion of cured patients will make the Kaplan-Meier estimator of survival function have a flat plateau at its tail, whose value indicates the overall cure rate. However, it may be difficult to estimate and compare the cure rates for all the subsets of interest in this way, due to the limit of sample sizes and curse of dimensionality. In the …

Barriers For Small Businesses To Adopt Sustainable Practices In The Sioux Falls Area, Meredith King

Honors Thesis

Sustainability is a broad concept that encompasses environmental, social, and economic factors to meet current and future needs. Many individuals and large businesses are becoming conscious of the effects they have on the planet and the people around them. However, despite the financial benefits and positive publicity of environmentalism, many businesses are not adopting sustainable practices. This study interviewed local business owners to answer the question “What are the main reasons that small businesses in the Sioux Falls area of South Dakota do or do not adopt sustainable practices that benefit the environment and the community?” Five business owners were …

Correlations Between Complex Human Phenotypes Vary By Genetic Background, Gender, And Environment, Michael Elgart, Matthew O Goodman, Carmen Isasi, Han Chen, Alanna C Morrison, Paul S De Vries, Huichun Xu, Ani W Manichaikul, Xiuqing Guo, Nora Franceschini, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Donald M Lloyd-Jones, Myriam Fornage, Adolfo Correa, Nancy L Heard-Costa, Ramachandran S Vasan, Ryan Hernandez, Robert C Kaplan, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from the Trans-Omics in Precision Medicine (TOPMed) program. We demonstrate substantial differences in both heritabilities and genetic correlations for multiple phenotypes and phenotype pairs between individuals of self-reported Black, Hispanic/Latino, and White backgrounds. We similarly observe differences in many of the genetic and environmental correlations between genders. To estimate the contribution of genetics to the observed phenotypic correlation, we …

In-Depth Analysis Of Alternative Splicing Landscape In Multiple Myeloma And Potential Role Of Dysregulated Splicing Factors, Anil Aktas Samur, Mariateresa Fulciniti, Herve Avet-Loiseau, Michael A Lopez, Sanika Derebail, Jill Corre, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Kenneth C Anderson, Giovanni Parmigiani, Mehmet K Samur, Nikhil C Munshi

Faculty, Staff and Student Publications

Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the alternative splicing (AS) landscape. We observed a large number of splicing pattern changes in MM cells compared to normal plasma cells (NPC). The most common events were alterations of mutually exclusive exons and exon skipping. Most of these events were observed in the absence of overall changes in gene expression and often impacted the coding potential of the alternatively spliced genes. To understand the molecular mechanisms driving frequent aberrant AS, we …

Labial Frenotomy For Symptomatic Isolated Upper Lip Tie, Cecilia G Freeman, Jason F Ohlstein, Nicholas A Rossi, John B Mcintire, Luis D Neve, Shiva Daram, Harold S Pine

Faculty, Staff and Student Publications

BACKGROUND: The benefits and challenges of successful breastfeeding for both mother and child have been well-established in the literature. While ankyloglossia, or tongue tie, alone or in combination with upper lip tie has been the focus of several previous studies, very few have directly addressed isolated symptomatic upper lip tie and the role of surgical correction for breastfeeding difficulties.

MATERIALS AND METHODS: Seven infants with isolated upper lip tie and breastfeeding difficulty were taken to the operating room for labial frenotomy. These infants were assessed at their follow-up visits for their degree of weight gain since their procedure. Their mothers …

Structural Insights Into Cardiolipin Replacement By Phosphatidylglycerol In A Cardiolipin-Lacking Yeast Respiratory Supercomplex, Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, Ana-Nicoleta Bondar, John L Spudich

Faculty, Staff and Student Publications

Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic silencing). KCRs are capable of discriminating K+ from Na+ without the conventional K+ selectivity filter found in classical K+ channels. The genome of H. catenoides also encodes a third paralog that is more permeable for Na+ than for K+. To identify structural motifs responsible for the unusual K+ selectivity of KCRs, we systematically analyzed a series of chimeras and mutants of this protein. We found that mutations of three critical residues in the …

Application Of Accuracy And Precision Evaluations Based On The Current United States And Indonesian Pharmacopoeias: A Critical Review, Gunawan Indrayanto

Makara Journal of Science

New methods for the evaluation of accuracy and precision are mentioned in the latest edition of the United States Pharmacopoeia (USP), whereas other validation parameters, that is, selectivity, linearity, range, and robustness, remained relatively unchanged. In obtaining reliable data from any chemical/pharmaceutical analysis, the analytical procedure must be validated or verified in accordance with the latest edition of the pharmacopoeia. Some review articles on the general validation methods have been published by the author. This present review will focus on the implementation and discussion of the accuracy and precision evaluation based on the current USP and Indonesian pharmacopoeia. Some examples …

Does Receiving A Sars-Cov-2 Antibody Test Result Change Covid-19 Protective Behaviors? Testing Risk Compensation In Undergraduate Students With A Randomized Controlled Trial, Christina Ludema, Molly S Rosenberg, Jonathan T Macy, Sina Kianersi, Maya Luetke, Chen Chen, Lilian Golzarri-Arroyo, Erin Ables, Kevin Maki, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: Risk compensation, or matching behavior to a perceived level of acceptable risk, can blunt the effectiveness of public health interventions. One area of possible risk compensation during the SARS-CoV-2 pandemic is antibody testing. While antibody tests are imperfect measures of immunity, results may influence risk perception and individual preventive actions. We conducted a randomized control trial to assess whether receiving antibody test results changed SARS-CoV-2 protective behaviors.

Purpose: Assess whether objective information about antibody status, particularly for those who are antibody negative and likely still susceptible to SARS-CoV-2 infection, increases protective behaviors. Secondarily, assess whether a positive antibody test …

Menstrual Health Among Adolescents And Young Adults In Rural Haiti., Emily R. Rupe, Jonathan Rodean, Emily A. Hurley, Melissa K. Miller, Marie Daphnee Boncoeur, Abbey R. Masonbrink

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Adolescent and young adult (AYA) females in low- and middle-income countries often face disparities in menstrual health (MH). Poor MH and lack of sexual and reproductive health education leads to school absenteeism, increasing risk for adverse psychosocial and educational outcomes. Further, disasters (e.g., earthquakes) are linked with unsafe living environments and sanitation facilities for women. We sought to describe MH perspectives and practices among AYAs in rural Haiti.

METHODS: We conducted a cross-sectional survey in two rural communities in Haiti. AYA females aged 14-24 years completed questions on demographics, the Menstrual Practice Needs Scale (36 items; MPNS-36) and the …

Emergency Remote Teaching Versus Planned Remote Teaching: Narrowing The Gap With Targeted Professional Development, Bonnie J. Covelli, Sudipta Roy

Higher Learning Research Communications

Objectives: This study reviews faculty members’ comfort level with remote teaching in the Fall 2020 semester to evaluate the effectiveness of the professional development workshops.

Method: Using survey research, we examined professional development activities and subsequent comfort level and ease of adjustment with remote teaching in Fall 2020.

Results: Following the training, faculty reported high planned usage of various online teaching tools and great comfort with using them. The data reveals some differences between part-time and full-time faculty members.

Conclusions: The experience gained in the emergency semester, combined with the targeted professional development workshops offered eased the stress of planned …

Women's Power In Hospital-Based Nursing: A Critical Qualitative Study, Kaitlyn C. George, Bret Lyman, Andy Pilarte Alcantara, Maya Stephenson

Faculty Publications

Aim: To understand the factors that affect power in hospital-based nursing and reveal how the female gender affects an individual's ability to feel empowered.

Design: Critical qualitative research design.

Method: Semi-structured interviews were conducted with nurses working in inpatient hospital settings in Utah and New Mexico. Data were collected from February to March 2022. Interviews were analysed using thematic analysis.

Results: Sixteen participants were interviewed. Six themes were identified from the data, four of which related to nurses' power at work, and two of which specifically related to how gender affects a nurse's ability to use power and feel empowered. …

Comparison Of Endoscopic Thyroidectomy By Complete Areola Approach And Conventional Open Surgery In The Treatment Of Differentiated Thyroid Carcinoma: A Retrospective Study And Meta-Analysis, Yuquan Yuan, Chenyu Sun, Tingjie Yin, Cong Shao, Bin Pan, Dengwei Lu, Shaodong Hou, Scott Lowe, Rachel Bentley, Shuya Chen, Christy Huang, Ce Cheng, Yaru Li, Bethany King, Qin Zhou, Cunye Yan, Fan Zhang

Student Publications

Background: The feasibility of endoscopic thyroidectomy by complete areola approach (ETCA) remains controversial. This study was conducted by combining our clinical data with the data obtained from a systematic review literature search to examine the effectiveness and safety of ETCA compared with conventional open thyroidectomy (COT) in differentiated thyroid carcinoma (DTC).

Methods: A total of 136 patients with a diagnosis of DTC who underwent unilateral thyroidectomy with central neck dissection from August 2020 to June 2021 were enrolled. The enrolled patients were divided into the ETCA group (n = 73) and the COT group (n = 63). The …

Human-Machine Communication: Complete Volume 5. Gender And Human-Machine Communication

Human-Machine Communication

This is the complete volume of HMC Volume 5

Designing A Loving Robot: A Social Construction Analysis Of A Sex Robot Creator’S Vision, Annette Masterson

Human-Machine Communication

In 2018, one of the world’s first sex robots was released by CEO Matt McMullen and his company, RealDoll. With artificial intelligence capabilities, the Harmony model is meant to support and converse with users. Using a social construction of technology theory lens, this study develops the theory’s fourth level of analysis, emphasizing mass media’s construction abilities. A critical discourse analysis of 38 publicity interviews found a tendency to emphasize the companionship of sex robots while envisioning a future where integration is normalized, and a sentient robot is possible. As the creator, McMullen’s vision could determine the future of robotic design, …

Gender Ambiguity In Voice-Based Assistants: Gender Perception And Influences Of Context, Sandra Mooshammer, Katrin Etzrodt

Human-Machine Communication

Recently emerging synthetic acoustically gender-ambiguous voices could contribute to dissolving the still prevailing genderism. Yet, are we indeed perceiving these voices as “unassignable”? Or are we trying to assimilate them into existing genders? To investigate the perceived ambiguity, we conducted an explorative 3 (male, female, ambiguous voice) × 3 (male, female, ambiguous topic) experiment. We found that, although participants perceived the gender-ambiguous voice as ambiguous, they used a profoundly wide range of the scale, indicating tendencies toward a gender. We uncovered a mild dissolve of gender roles. Neither the listener’s gender nor the personal gender stereotypes impacted the perception. However, …

Gender And Human-Machine Communication: Where Are We?, Leopoldina Fortunati, Autumn P. Edwards

Human-Machine Communication

In this introduction to the fifth volume of the journal Human-Machine Communication, we present and discuss the five articles focusing on gender and human-machine communication. In this essay, we will analyze the theme of gender, including how this notion has historically and politically been set up, and for what reasons. We will start by considering gender in in-person communication, then we will progress to consider what happens to gender when it is mediated by the most important ICTs that preceded HMC: the telephone, mobile phone, and computer-mediated communication (CMC). We outline the historical framework necessary to analyze the last section …

Review Of A Revolution In Canvas: The Rise Of Women Artists In Britain And France, 1760-1830, By Paris A. Spies-Gans, Gabrielle Stecher

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Paris A. Spies-Gans, A Revolution on Canvas: The Rise of Women Artists in Britain and France, 1760-1830 by Gabrielle Stecher

Review Of Placing Charlotte Smith, Eds Elizabeth A. Dolan And Jacqueline M. Labbe, Heather Heckman-Mckenna

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Placing Charlotte Smith edited by Elizabeth A. Dolan and Jacqueline M. Labbe, written by Heather Heckman-McKenna

Review Of Female Husbands: A Trans History, By Jen Manion, Jeremy Chow

ABO: Interactive Journal for Women in the Arts, 1640–1830

This review evaluates Jen Manion's Female Husbands: A Trans History.

Review Of The Life And Legend Of Catterina Vizzani: Sexual Identity, Science And Sensationalism In Eighteenth-Century Italy And England, By Clorinda Donato, Ula E. Lukszo Klein

ABO: Interactive Journal for Women in the Arts, 1640–1830

Review of The Life and Legend of Catterina Vizzani: Sexual Identity, Science and Sensationalism in Eighteenth-Century Italy and England, by Clorinda Donato, written by Ula Lukszo Klein. Oxford University Studies in the Enlightenment, Liverpool University Press, 2020, 347 pp., 3 b/w images. ISBN: 978-1-789-62221-8

Review Of The Novel Stage: Narrative Form From The Restoration To Jane Austen, By Marcie Frank, Kathleen E. Urda

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Marcie Frank's The Novel Stage: Narrative Form from the Restoration to Jane Austen by Kathleen E. Urda

Negotiating Gender, Representing Landscape: Teaching Lady Anne Lindsay Barnard’S Letters, Journals And Watercolours From The Cape Colony (1797–1801), Lenka Filipova

ABO: Interactive Journal for Women in the Arts, 1640–1830

The article focuses on Lady Anne Lindsay Barnard’s letters, journals and watercolours that she produced during her stay at the Cape Colony (1797–1801). Combining a series of tasks focused on close reading of Barnard’s work and a critical discussion of the historical context, the article provides a teaching strategy to examine her work with respect to the gendered discourse of the eighteenth century, and her approach to the Cape landscape and its inhabitants which both employs and, significantly, subverts contemporaneous conventions. More specifically, the tasks draw attention to Barnard’s use of ‘the modesty topos’ and the way she uses rhetorical …

Teaching Mary Wollstonecraft's Travelogue Of Historical Trauma, Annette Hulbert

ABO: Interactive Journal for Women in the Arts, 1640–1830

Abstract: I teach Mary Wollstonecraft’s Letters Written During a Short Residence in Sweden, Norway, and Denmark (1796) in an undergraduate English literature course on “Survival Narratives of the Eighteenth Century” at the University of California, Davis. The aim of this course is to show how significant perilous voyages were to the ways in which writers in eighteenth-century Britain imagined and interpreted their world. The course draws from the burst of new scholarship on rethinking the traditional “rise of the novel” narrative in imperial, oceanic, and global contexts and develops interpretive frameworks for the eighteenth century’s changing relationship to commerce and …

Ripped From The Headlines: Teaching Lady Mary Wortley Montagu's Turkish Letters In The Context Of 21st-Century Controversies, Susan Spencer

ABO: Interactive Journal for Women in the Arts, 1640–1830

In the long shadow of 9/11 and the ongoing COVID pandemic, Lady Mary Wortley Montagu’s Turkish Embassy Letters connect with the lived experience of today’s students, especially the cluster of eight letters dated 1 April 1717. By emphasizing parallels between Montagu’s observations and the students’ own lives, The Turkish Embassy Letters can add a modern dimension to the eighteenth century in general, challenges of gender, and texts written in and about the Muslim world.

Teaching Eliza Fay's Original Letters From India (1817) Through Classroom Editing, Lacy Marschalk

ABO: Interactive Journal for Women in the Arts, 1640–1830

Travel writing is an ever-growing area of interest in eighteenth-century studies, but it can be difficult to teach. Students often find the writing dry and unrelatable, and faculty who have had little experience with travel writing in their own educations may not know which texts would prove useful to their courses. In this article, I discuss the travel narrative with which I've found the most pedagogical success, Eliza Fay's Original Letters from India (1817). Fay's initial journey to India includes a range of captivating adventures, including encounters with Marie Antoinette in Paris, bandits in Egypt, and Hyder Ali in Calicut, …

Concise Collections: Teaching British Women Travelers, Tiffany Potter

ABO: Interactive Journal for Women in the Arts, 1640–1830

No abstract provided.

Cooking Up Knowledge: Materiality, Recipes, And Jane Barker’S A Patch-Work Screen For The Ladies, Carolin Boettcher

ABO: Interactive Journal for Women in the Arts, 1640–1830

The recipes included in Jane Barker’s A Patch-Work Screen for the Ladies (1723) appear to be some of the most jarring and out-of-context inclusions in the narrative. This article explores the relationship between Barker’s novel and the form of the recipe collection in the late seventeenth and early eighteenth centuries on both a material and an epistemological level. The entanglements between recipes and the patchwork screen not only point to the processes of constructing and conveying knowledge, but also to the materiality of these processes as Galesia and the Lady build the patchwork screen. Her focus on the materiality of …

Postures After The Antique In Eighteenth-Century Portraits Of Women, Lauren K. Disalvo

ABO: Interactive Journal for Women in the Arts, 1640–1830

This paper re-examines the relationship between eighteenth-century portraiture and the antique where women adopt the postures of floating female figures from Pompeiian wall paintings in eighteenth-century portraiture. I argue that eighteenth-century floating portraits afforded their female sitters an opportunity to assert classical knowledge while adhering to typical conventions of femininity.

Taking Chardin's Kitchen Maids Seriously, Danielle Ezor

ABO: Interactive Journal for Women in the Arts, 1640–1830

Historically, Jean-Siméon Chardin’s The Kitchen Maid and Return from the Market have been characterized as austere images of middle-class virtue. However, the engravings made after these paintings include verses that place the paintings within the satirical tradition. Thus, there is a misalignment between the canonical interpretation of Chardin’s kitchen maids as virtuous and the satirical understanding of these paintings. I reconcile these two contradictory interpretations by offering a feminist reinterpretation of Chardin’s The Kitchen Maid and Return from the Market, juxtaposing the prints and their satirical verses and considering the female viewer. In my analysis, I focus on small, …