Digital Commons Network^™

Combating Hypertension Beyond Genome-Wide Association Studies: Microbiome And Artificial Intelligence As Opportunities For Precision Medicine, Sachin Aryal, Ishan Manandhar, Xue Mei, Beng S Yeoh, Ramakumar Tummala, Piu Saha, Islam Osman, Jasenka Zubcevic, David J Durgan, Matam Vijay-Kumar, Bina Joe

Faculty, Staff and Students Publications

The single largest contributor to human mortality is cardiovascular disease, the top risk factor for which is hypertension (HTN). The last two decades have placed much emphasis on the identification of genetic factors contributing to HTN. As a result, over 1,500 genetic alleles have been associated with human HTN. Mapping studies using genetic models of HTN have yielded hundreds of blood pressure (BP) loci but their individual effects on BP are minor, which limits opportunities to target them in the clinic. The value of collecting genome-wide association data is evident in ongoing research, which is beginning to utilize these data …

Open-Source, Highly Efficient, Post-Acquisition Synchronization For 4d Dual-Contrast Imaging Of The Mouse Embryonic Heart Over Development With Optical Coherence Tomography, Andre C Faubert, Irina V Larina, Shang Wang

Faculty, Staff and Students Publications

Dynamic imaging of the beating embryonic heart in 3D is critical for understanding cardiac development and defects. Optical coherence tomography (OCT) plays an important role in embryonic heart imaging with its unique imaging scale and label-free contrasts. In particular, 4D (3D + time) OCT imaging enabled biomechanical analysis of the developing heart in various animal models. While ultrafast OCT systems allow for direct volumetric imaging of the beating heart, the imaging speed remains limited, leading to an image quality inferior to that produced by post-acquisition synchronization. As OCT systems become increasingly available to a wide range of biomedical researchers, a …

Optical Coherence Tomography For Dynamic Investigation Of Mammalian Reproductive Processes, Kohei Umezu, Irina V Larina

Faculty, Staff and Students Publications

The biological events associated with mammalian reproductive processes are highly dynamic and tightly regulated by molecular, genetic, and biomechanical factors. Implementation of live imaging in reproductive research is vital for the advancement of our understanding of normal reproductive physiology and for improving the management of reproductive disorders. Optical coherence tomography (OCT) is emerging as a promising tool for dynamic volumetric imaging of various reproductive processes in mice and other animal models. In this review, we summarize recent studies employing OCT-based approaches toward the investigation of reproductive processes in both, males and females. We describe how OCT can be applied to …

Sphingolipids In Neurodegenerative Diseases, Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J Bellen

Faculty, Staff and Students Publications

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia (HSP), infantile neuroaxonal dystrophy (INAD), Friedreich’s ataxia (FRDA), as well as some forms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Many of these diseases have been modeled in Drosophila melanogaster and are associated with elevated levels of ceramides. Similar changes have also been reported in vertebrate cells and mouse models. Here, we …

Chromosomal Microarray Analysis Supplements Exome Sequencing To Diagnose Children With Suspected Inborn Errors Of Immunity, Breanna J Beers, Morgan N Similuk, Rajarshi Ghosh, Bryce A Seifert, Leila Jamal, Michael Kamen, Michael R Setzer, Colleen Jodarski, Rylee Duncan, Devin Hunt, Madison Mixer, Wenjia Cao, Weimin Bi, Daniel Veltri, Eric Karlins, Lingwen Zhang, Zhiwen Li, Andrew J Oler, Kathleen Jevtich, Yunting Yu, Haley Hullfish, Bibiana Bielekova, Pamela Frischmeyer-Guerrerio, An Dang Do, Laryssa A Huryn, Kenneth N Olivier, Helen C Su, Jonathan J Lyons, Christa S Zerbe, V Koneti Rao, Michael D Keller, Alexandra F Freeman, Steven M Holland, Luis M Franco, Magdalena A Walkiewicz, Jia Yan

Faculty, Staff and Students Publications

PURPOSE: Though copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine the diagnostic contribution of CNVs using genome-wide chromosomal microarray analysis (CMA) in children with IEI.

METHODS: We performed exome sequencing (ES) and CMA for 332 unrelated pediatric probands referred for evaluation of IEI. The analysis included primary, secondary, and incidental findings.

RESULTS: Of the 332 probands, 134 (40.4%) received molecular diagnoses. Of these, 116/134 (86.6%) were diagnosed by ES alone. An additional 15/134 (11.2%) were diagnosed by …

Understanding Advanced Practice Providers' Personal Factors That Influence Evaluating And Referring For Sleep Disorders In Pediatric And Adolescent Young Adult Cancer Survivors, Lindsay R. Melson

Dissertations

Pediatric and adolescent young adult (AYA) cancer survivors disproportionately experience sleep disorders compared to healthy peers. This dissertation examines the facilitators and barriers that influence advanced practice providers' (APPs) ability to evaluate and refer pediatric/AYA hematology oncology cancer survivors to sleep specialists. The first manuscript provides an integrative review of APPs' behaviors in screening for sleep disorders in pediatric/AYA cancer survivors using the Social Cognitive Theory as a guide. The second manuscript defines the concept of sleep disorders in pediatric cancer survivors using the Walker and Avant method. The third manuscript provides a qualitative analysis from interviews with hematology/oncology (heme/onc) …

Community-Based Early Dementia Advance Care Planning In The United States, Christine Noelle Flaherty

Dissertations

Dementia Advance Care Planning (ACP) promotes quality of life through discussions and decisions about goals of care and end-of-life wishes. However, ACP is rarely introduced in the community setting, and ACP is commonly deferred until advanced dementia when the patient can no longer communicate. The purpose of this three-manuscript dissertation was to advance the understanding of community-based early dementia ACP through an examination of the literature (manuscript one), the development of the dementia public health exposome conceptual framework (manuscript two), and the exploration of perceptions of ACP amongst dementia clinicians, dementia caregivers, and individuals with preclinical dementia in a dementia …

The Radical Reformers (Anabaptists) And Seventh-Day Adventism, Trevor O'Reggio

Faculty Publications

No abstract provided.

From Market Making To Matchmaking: Does Bank Regulation Harm Market Liquidity?, Gideon Saar, Jian Sun, Ron Yang, Haoxiang Zhu

Research Collection Lee Kong Chian School Of Business

Post-crisis bank regulations raised market-making costs for bank-affiliated dealers. We show that this can, somewhat surprisingly, improve overall investor welfare and reduce average transaction costs despite the increased cost of immediacy. Bank dealers in OTC markets optimize between two parallel trading mechanisms: market making and matchmaking. Bank regulations that increase market-making costs change the market structure by intensifying competitive pressure from non-bank dealers and incentivizing bank dealers to shift their business toward matchmaking. Thus, post-crisis bank regulations have the (unintended) benefit of replacing costly bank balance sheets with a more efficient form of financial intermediation.

The Effect Of A Plasma Next-Generation Sequencing Test On Antimicrobial Management In Immunocompetent And Immunocompromised Patients-A Single-Center Retrospective Study, Denise Marie A Francisco, Laila Woc-Colburn, Travis J Carlson, Todd Lasco, Miriam Barrett, Mayar Al Mohajer

Faculty, Staff and Students Publications

Objective: To describe the use of next-generation sequencing (NGS) and to determine whether NGS leads to changes in antimicrobial management.

Design and setting: This retrospective cohort study included patients aged ≥18 years admitted to a single tertiary-care center in Houston, Texas, with an NGS test performed between January 1, 2017, and December 31, 2018.

Patients: In total, 167 NGS tests were performed. Most patients were of non-Hispanic ethnicity (n = 129), white (n = 106), and male (n = 116), with a mean age of 52 years (SD, 16). Moreover, 61 patients were immunocompromised: solid-organ transplant (n = 30), patients …

Healthcare Workers' Well-Being: A Systematic Review Of Positive Psychology Interventions, Alexandra P Townsley, Jenny Li-Wang, Rajani Katta

Faculty, Staff and Students Publications

Given persistent occupational stressors and multiple challenges in the delivery of healthcare, there is an increased focus on the well-being of healthcare workers. Responding to these challenges will require a multipronged approach, focusing on system level, organization, and individual actions. Positive psychology interventions (PPIs) represent a promising area for individual action. This systematic review indicates that PPI, delivered via many methods, holds promise for improving the well-being of healthcare workers, although there is a clear need for additional randomized controlled trials utilizing defined and standardized outcome measures. In this review, the most commonly evaluated PPIs were mindfulness-based or gratitude-based interventions. …

The Current Burden And Future Solutions For Preoperative Cataract-Refractive Evaluation Diagnostic Devices: A Modified Delphi Study, Bonnie An Henderson, Jaime Aramberri, Robin Vann, Adi Abulafia, Margaret Ainslie-Garcia, John Berdahl, Nicole Ferko, Kjell Gunnar Gundersen, So Goto, Preeya Gupta, Samuel Multack, Elizabeth Persaud, Duna Raoof, Giacomo Savini, H John Shammas, Li Wang, Wendy Zhi Wang

Faculty, Staff and Students Publications

Purpose: To obtain consensus on the key areas of burden associated with existing devices and to understand the requirements for a comprehensive next-generation diagnostic device to be able to solve current challenges and provide more accurate prediction of intraocular lens (IOL) power and presbyopia correction IOL success.

Patients and methods: Thirteen expert refractive cataract surgeons including three steering committee (SC) members constituted the voting panel. Three rounds of voting included a Round 1 structured electronic questionnaire, Round 2 virtual face-to-face meeting, and Round 3 electronic questionnaire to obtain consensus on topics related to current limitations and future solutions for preoperative …

Editorial: Identifying Genetics-Based Mechanisms And Treatments For Neurodevelopmental And Psychiatric Disorders Through Data Integration, Kaifang Pang, Li Wang, Suhua Chang

Faculty, Staff and Students Publications

No abstract provided.

Cumulative Comorbid Conditions Influence Mortality Risk After Staged Palliation For Hypoplastic Left Heart Syndrome And Variants, Emily R Backes, Natasha S Afonso, Danielle Guffey, James S Tweddell, Sarah Tabbutt, Nancy A Rudd, Ginny O'Harrow, Silvana Molossi, George M Hoffman, Garick Hill, Jeffrey S Heinle, Priya Bhat, Jeffrey B Anderson, Nancy S Ghanayem

Faculty, Staff and Students Publications

Objective: Prematurity, low birth weight, genetic syndromes, extracardiac conditions, and secondary cardiac lesions are considered high-risk conditions associated with mortality after stage 1 palliation. We report the impact of these conditions on outcomes from a prospective multicenter improvement collaborative.

Methods: The National Pediatric Cardiology Quality Improvement Collaborative Phase II registry was queried. Comorbid conditions were categorized and quantified to determine the cumulative burden of high-risk diagnoses on survival to the first birthday. Logistic regression was applied to evaluate factors associated with mortality.

Results: Of the 1421 participants, 40% (575) had at least 1 high-risk condition. The aggregate high-risk group had …

Lymphocytic Panhypophysitis Mimicking Glaucoma: Case Report, Phillip Howard Keys, Patrick J Hunt, Clement Anozie, Samir Cayenne, Pamela Davila-Siliezar, Noor Laylani, Andrew G Lee

Faculty, Staff and Students Publications

Lymphocytic hypophysitis (LH) is a primary inflammatory disorder of the pituitary gland and infundibulum that commonly manifests in both mass effect and endocrinologic symptoms. Although the exact pathophysiology remains unclear, it has been increasingly linked to an autoimmune process. Complications arise by two separate mechanisms. Inflammation in the sella can lead to headaches and visual field defects. Pituitary inflammation and, chronically, fibrosis interfere with the gland's hormone-secreting capacity, often resulting in various endocrinopathies such as polyuria, polydipsia, amenorrhea, and others. While final histologic classification requires pathologic evaluation, diagnosis can often be made clinically with appropriate imaging. Treatment often consists of …

Imaging Synaptic Density In Depression, Sophie E Holmes, Chadi Abdallah, Irina Esterlis

Faculty, Staff and Students Publications

Major depressive disorder is a prevalent and heterogeneous disorder with treatment resistance in at least 50% of individuals. Most of the initial studies focused on the monoamine system; however, recently other mechanisms have come under investigation. Specific to the current issue, studies show synaptic involvement in depression. Other articles in this issue report on reductions in synaptic density, dendritic spines, boutons and glia associated with stress and depression. Importantly, it appears that some drugs (e.g., ketamine) may lead to rapid synaptic restoration or synaptogenesis. Direct evidence for this comes from preclinical work. However, neuroimaging studies, such as magnetic resonance imaging …

Clinical Trial Design Challenges And Opportunities For Emerging Treatments For Opioid Use Disorder: A Review, Brian D Kiluk, Bethea A Kleykamp, Sandra D Comer, Roland R Griffiths, Andrew S Huhn, Matthew W Johnson, Kyle M Kampman, Marco Pravetoni, Kenzie L Preston, Ryan Vandrey, Cecilia L Bergeria, Michael P Bogenschutz, Randall T Brown, Kelly E Dunn, Robert H Dworkin, Patrick H Finan, Peter S Hendricks, Elisabeth J Houtsmuller, Thomas R Kosten, Dustin C Lee, Frances R Levin, Aimee Mcrae-Clark, Charles L Raison, Kurt Rasmussen, Dennis C Turk, Roger D Weiss, Eric C Strain

Faculty, Staff and Students Publications

Importance: Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD treatments that target the endogenous μ-opioid receptor (MOR) system. The goal of this review is to highlight unique clinical trial design considerations for the study of emerging treatments for OUD that address targets beyond the MOR system. In November 2019, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the US Food and Drug Administration sponsored a meeting to discuss the current evidence regarding potential treatments for OUD, including cannabinoids, …

Unchoreographed Dance: Trust And Venture Into Vulnerability—Building A Plural, Organic, And Recursive Collective, Miryam Espinosa-Dulanto, Eunice Lerma, Karin A. Lewis, Vejoya Viren

Bilingual and Literacy Studies Faculty Publications

In this autoethnography, we—four Hispanic Serving Institution colleagues at the USA–Mexican frontera—share our process of building a collective where a plural, organic, vulnerable, and recursive space was created. In this space, through readings, conversations, feedings, discussions, and memories, un/anticipated stories emerge…in our unchoreographed writings, we whirl, twirl, collide, and craft our collective space, which was at once chaotic, cathartic, and sustaining.

Primary Spinal Intramedullary Anaplastic Ganglioglioma In A Pediatric Patient, Huy Dang, Abdul Basit Khan, Nisha Gadgil, Marc Prablek, Frank Y Lin, Melissa M Blessing, Guillermo Aldave, David Bauer

Faculty, Staff and Students Publications

BACKGROUND: Gangliogliomas (GGs) are rare tumors of the central nervous system composed of neoplastic neural and glial cells and are typically low-grade. Intramedullary spinal anaplastic GGs (AGG) are rare, poorly understood, and often aggressive tumors that can result in widespread progression along the craniospinal axis. Due to the rarity of these tumors, data are lacking to guide clinical and pathologic diagnosis and standard of care treatment. Here, we present a case of pediatric spinal AGG to provide information on our institutional approach to work-up and to highlight unique molecular pathology.

CASE DESCRIPTION: A 13-year-old female presented with signs of spinal …

Survive And Thrive: An Exploration Of Methods Implemented By Small Businesses In The Construction Industry To Sustain Their Business Beyond 5 Years, Tamar Barsoumian

Theses and Dissertations

Small businesses represent an influential portion of the American economy yet retain a high rate of closure especially in their early years, therefore; this study sought to address a lack of available research regarding small businesses in the construction industry, by investigating the methods and strategies existing small business owners use to support business survivability, in the regionally specific area of Southern California. The purpose of this study was to investigate strategies used by existing construction industry small businesses, identify the challenges experienced as a construction industry small business organization in Southern California, and determine how the small business owners …

Reasonable Accommodation Requests: Fair Evaluation And The Role Of Decision Makers, Mona Hawkins

Theses and Dissertations

The purpose of this qualitative study was to examine fair evaluations and the role of the decision-makers in the reasonable accommodation process. In many instances, fair evaluations in the reasonable accommodation process which disabled employees experienced, were challenging and looked upon as perceived discrimination in decision-making process. A review of the literature identified further clarification and insight into educating decision-makers about the disability laws, and then altering their behavior in granting reasonable accommodations. The literature progressed with discussions surrounding why every qualified disabled employee should be accommodated as long as the reasonable accommodation is not an undue hardship to the …

Marketization Without Marginalization? Approaches To Integration In A Dual Enrollment Magnet School, Shannon Mumolo

Theses and Dissertations

Despite the well-documented benefits of integration and Southern California’s racial, socioeconomic, and linguistic diversity, California and U.S. efforts to promote integrated magnet schools have been minimal and primarily driven by local districts. Attempts to evaluate magnet programs primarily focus on student outcomes, yet surprisingly few studies examine approaches used by school leaders to establish and achieve program outcomes. This study contributes to the knowledge and practice of magnet implementation by exploring one California high school’s efforts to establish a dual enrollment magnet program. An explanatory mixed methods case study design was used to understand how school leaders promoted student integration …

A Systematic Review On The Relationship Between Attachment Styles And Chronic Pain, Samantha M. Cohen

Theses and Dissertations

Chronic pain (CP), a leading cause of disability, is associated with addiction, physical and psychosocial impairment and tremendous financial burden. Childhood experiences contribute to the genesis of different attachment styles. Attachment theory offers a useful framework for the conceptualization of CP, with different attachment styles impacting the experience and clinical manifestations of CP. This systematic review aims to evaluate the relationship between attachment styles and CP, to investigate which attachment styles pose the greatest risk for CP, to examine how CP is expressed in the context of different attachment styles, and to gain insight regarding the treatment approach to CP. …

The Meta-Leadership Inventory: Developing A Valid And Reliable Instrument For International School Leaders, Matthew D. Wilkens

Theses and Dissertations

International school leaders must be prepared to steer their schools through ongoing crises and changes, regardless of the factors creating the crises and the need for swift change. To achieve the best possible outcomes from these dynamic situations, international school leaders must strategically deploy skills and abilities delineated by the Meta-leadership framework developed by Marcus et al.(2015). This study aimed to develop a valid and reliable instrument that measures the Meta-leadership competencies of international school leaders: the Meta-leadership Inventory for International School Leaders (MLI-ISL). This instrument development study involved a three-phase design. An initial set of items based on a …

Exploring Leaders' Sensemaking Of Emergent Global Norms For Open Science: A Mixed Methods Discourse Analysis Of Unesco’S Multistakeholder Initiative, Lisa Cuevas Shaw

Theses and Dissertations

In November 2021, all 193 United Nations Member States adopted the United Nations Educational, Scientific, and Cultural Organization’s (UNESCO) Recommendation on Open Science (UNESCO, 2021a), which signaled a shared commitment to globally recognized standards for open science. However, as with other normative instruments established by intergovernmental organizations (IGOs) such as UNESCO, the ways in which local, national, and regional leaders will implement the recommendation can and will vary (Finnemore, 1993). Top-down and bottom-up coordination across international stakeholders in the research system is critical for the framework to be effective in driving global policy implementation and enabling sustained research culture change. …

Effective Approaches To Establishing And Maintaining A Strong Therapeutic Alliance With Men: A Qualitative Systematic Review, Ferdinand Aliga

Theses and Dissertations

Consequences of mental health issues in men that are left untreated can affect a man’s partner, friends, family, and co-workers. While much research has described the efficacy of psychotherapy with this population, adult male clients may be hesitant to even start treatment. This is due to several reasons including stigma, toxic masculinity, and accessibility. To combat this, the American Psychological Association published Guidelines for Psychological Practice with Boys and Men in 2018. Research from 2005--the year the guidelines were conceived--to 2021 suggests that three therapeutic approaches are among the most effective in establishing or maintaining a therapeutic alliance. The approaches …

Transformational Leadership Strategies In U.S. Public Universities, Jason C. Hardman

Theses and Dissertations

This qualitative study explores the transformational leadership strategies used by university leaders to transform their respective institutions of higher education in the post-pandemic era. The study builds on Bass's (1985a) transformational leadership model, and the guiding research question is, "What transformational leadership strategies do university leaders use to transform university environments?" The study utilizes a narrative inquiry approach to collect and analyze data from publicly available and accessible sources. The data analysis highlights four themes of transformational leadership practices, including idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration. The findings reveal that transformational leaders exhibit high moral standards, personal …

African American Coaches In Athletics: A Study Of Enabling And Inhibiting Factors Impacting Leadership Success, Lamar Lawrence

Theses and Dissertations

This qualitative research focused on identifying and addressing the enabling and inhibiting factors that have influenced the careers of African American National Collegiate Athletic Association (NCAA) Division I head basketball coaches. The researcher used a phenomenological approach to discover and understand the lived experiences of African American NCAA Division I men's head basketball coaches that are considered to be successful leaders in their field in order to gain their perspective and personal insight into barriers and potential solutions to those barriers in this particular field. Active and systemic discrimination, along with institutionalized racism and bias, are essential factors in this …

Couple-Based Therapeutic Interventions Aimed At Treating The Individual And Relational Impact Of Childhood Abuse, Megan A. Maguire

Theses and Dissertations

Childhood abuse can have a significant and lasting impact on an individual's mental health and relationships, including their ability to trust, communicate, and form healthy attachments. While the greater literature focuses on individual interventions to address childhood trauma, there is limited research on the potential positive impact of a couple-based therapeutic approach on outcomes of individual mental health and relationship distress. This dissertation sought to summarize empirically researched couples-based psychotherapies designed to address the effects of childhood abuse and review evidence regarding therapeutic outcomes. The dissertation implemented the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to ensure a …

A Preliminary Exploration Of The Workplace Expectations Of Generation Z Amidst Covid-19, Elizabeth Robertson

Theses and Dissertations

For the first time in modern history, up to five generations are working side-by-side in the same organizations. The high number of generations working together can cause intergenerational conflict. Generation Z (Gen Z), born after 1995, is significantly different from previous generations due to the cultural realities that have shaped their development. Gen Z has their own attitudes, beliefs, and expectations about the workplace and the centrality of work. The purpose of this qualitative phenomenological study was to explore the attitudes, beliefs, values, and expectations about work and toward leadership in the workplace and how those expectations may have been …