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Clinical Outcomes, Patient-Reported Outcomes, And Efficiency Of Static Computer-Assisted Sinus Floor Augmentation: A Randomized Controlled Trial, Nattakarn Narongchai Jan 2024

Clinical Outcomes, Patient-Reported Outcomes, And Efficiency Of Static Computer-Assisted Sinus Floor Augmentation: A Randomized Controlled Trial, Nattakarn Narongchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To investigate the patient-reported ,clinical outcomes and efficacy of static computer-assisted sinus floor augmentation (SCA-SFA), compared to freehand approach. Material and methods: 40 patients underwent lateral sinus augmentation (20 freehand-SFA + 20 SCA-SFA). Patient-reported outcomes were recorded in Visual Analog Scale (VAS) on days 1-7, 14 and intra- and post-operative complications were recorded on week 2,4 after surgery. Duration and operators’ assessment of SCA-SFA efficacy were recorded. Results: No statistically significant difference was found between the two groups with regards to PROMs and intra-, post-operative complications, apart from higher level of swelling for SCA-SFA patients on day 2 after …

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Association Between Ageing Perception And Oral Health Dimensions In Thai Older People, Nattapat Khongsirisombat Jan 2024

Association Between Ageing Perception And Oral Health Dimensions In Thai Older People, Nattapat Khongsirisombat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Maintaining good oral health as people age is just as important as overall health. Ageing perception, how individuals perceive their ageing process, has been shown to affect health outcomes. However, the relationship between ageing perception and oral health, including oral health-related quality of life (OHRQoL), remains underexplored. Objective: This study explores the associations between ageing perception, oral health dimensions, and OHRQoL among older Thai people. Methods: The study was conducted in two phases. Phase I translated and validated the Thai version of the short-form Attitudes to Ageing Questionnaire (Thai AAQ-SF). Phase II focused on hypothesis testing through structured interviews …

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The Effect Of Surface Treatments And Coffee Thermocycling On Color Stability And Translucency Of Cad-Cam Polychromatic High-Translucent Zirconia Compared With Lithium Disilicate Glass Ceramic, Ratchaphat Khomprang Jan 2024

The Effect Of Surface Treatments And Coffee Thermocycling On Color Stability And Translucency Of Cad-Cam Polychromatic High-Translucent Zirconia Compared With Lithium Disilicate Glass Ceramic, Ratchaphat Khomprang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To evaluate effects of surface treatments on the color stability (ΔE) and translucency parameter (TP) of Gradient Multilayered yttria-stabilized Zirconia (GMZ), Ultra-translucent multilayered Zirconia (UTML) and lithium disilicate glass ceramic (LD) under coffee thermocycling. Methods: 27 samples from each material were classified into 3 groups (polished, glazed, and glazed+pumice). A dental spectrophotometer was utilized to measure the color coordinates before and after thermocycling. The color and translucency differences (ΔE and ΔTP) measurements were determined using the CIELAB formula, and their corresponding 50%:50% perceptibility and acceptability thresholds (PT and AT) were used for analysis. One-way ANOVA and Two-way ANOVA was …

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Effect Of Chairside Silicone Polishing Systems On The Surface Roughness Of Cad/Cam Milled And Conventional Denture Base Materials, Sarita Apiromwijit Jan 2024

Effect Of Chairside Silicone Polishing Systems On The Surface Roughness Of Cad/Cam Milled And Conventional Denture Base Materials, Sarita Apiromwijit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: The objective of this study was to evaluate the effect of two commercial chairside polishing systems compared with conventional laboratory polishing on the surface roughness of two types of denture base materials. Methods: Square-shaped specimens (8x8x5 mm) were fabricated from CAD/CAM milled and heat-polymerized denture base materials. Each specimen was ground with tungsten carbide and then divided into three groups according to polishing techniques(n=8): Exa technique, AcryPoint, and conventional laboratory polishing. The roughness (Ra) values were measured using a non-contact profilometer after finishing with tungsten carbide bur, every 30 seconds with each subsequent polisher (rough, medium, and fine) of …

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Oral Health-Related Quality Of Life, Patient’S Satisfaction And The Clinical Performance Of Anterior Ceramic Veneers Criteria In 10 Years Clinical Cross-Section Study, Thitiorn Panayong Jan 2024

Oral Health-Related Quality Of Life, Patient’S Satisfaction And The Clinical Performance Of Anterior Ceramic Veneers Criteria In 10 Years Clinical Cross-Section Study, Thitiorn Panayong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: The purpose of this study was to evaluate the clinical performance of ceramic veneers after 9-10 years, assess oral health-related quality of life and patient’s satisfaction, and examine the associations between them. Materials and Methods: 30 patients who treated with ceramic veneers aged 9 to 10 years were recalled for a clinical examination. Each participant completed a questionnaire on satisfaction and oral health-related quality of life, using the Oral Impact on Daily Performance (OIDP) scale. The Chi-square or Fisher Exact test was used to assess associations between tooth position and professional evaluations of veneer success and individual items. Consistency …

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The Study On Surface Roughness And Corrosion Resistance Of Electropolished Laser Powder Bed Fusion Ti-6al-4v Eli Alloy, Venus Chatpaiboonwat Jan 2024

The Study On Surface Roughness And Corrosion Resistance Of Electropolished Laser Powder Bed Fusion Ti-6al-4v Eli Alloy, Venus Chatpaiboonwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Ti6Al4V ELI alloy produced via Laser Powder Bed Fusion (L-PBF) has drawn interest for usage in dental applications. However, surface finishing is an important property that can be managed by various methods. The purpose of this study was to investigate the effects of electropolishing (EP) on the surface roughness and corrosion resistance of L-PBF Ti6Al4V ELI alloy. The present study explored the influence of current density, voltage, and distance on the surface quality and corrosion behavior. The results showed that EP significantly reduced the surface roughness and enhanced corrosion resistance of printed Ti6Al4V ELI alloy with the best result …

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Studying The Relationship Between Polyherbal Mouthwash And Oral Microbiome, Waris Wattanawongwan Jan 2024

Studying The Relationship Between Polyherbal Mouthwash And Oral Microbiome, Waris Wattanawongwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: This study aimed to comparatively evaluate the effects of polyherbal, chlorhexidine (CHX), and normal saline (NCC) mouthwashes on oral microbiome composition, microbial metabolic pathways, and patient-reported outcomes, exploring polyherbal alternatives in response to CHX-associated dysbiosis. Methods: A randomized, double-blind trial was conducted among 27 gingivitis patients, randomly assigned to polyherbal, CHX, or NCC mouthwash groups. Participants used the mouthwash twice daily for 7 days. Saliva samples were analyzed via 16S rRNA sequencing. Microbial diversity (alpha and beta diversity) and composition were statistically evaluated. Differential taxa and pathways were identified using FDR-corrected Wilcoxon tests and log₂ fold-change analysis. Patient-reported outcomes …

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Effects Of Ai-Assisted Collaborative Learning On English Speaking Skill Of Myanmar Undergraduate Students, Tin Lin Kyaw Jan 2024

Effects Of Ai-Assisted Collaborative Learning On English Speaking Skill Of Myanmar Undergraduate Students, Tin Lin Kyaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

The present study endeavored to: 1) examine effects of AI-assisted collaborative learning on English speaking skill of Myanmar undergraduate students, and 2) explore opinions of Myanmar undergraduate students towards AI-assisted collaborative learning. This research is a quasi-experimental study. The participants were 32 participants, selected through convenience sampling, as they were administered English speaking lessons for eight class periods. The instructional instrument involved lesson plans, while the research instruments contained pre- and post-tests of English speaking, and semi-structured interviews. The research findings revealed that 1) there were substantial developments in students’ English speaking skill after the implementation of AI-assisted collaborative learning, …

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Contextual Matching And Aggregation Network For Mri Image Super-Resolution, Abdulhamid Muhammad Jan 2024

Contextual Matching And Aggregation Network For Mri Image Super-Resolution, Abdulhamid Muhammad

Chulalongkorn University Theses and Dissertations (Chula ETD)

High-resolution (HR) Magnetic Resonance Imaging (MRI) provides detailed visualization of healthy and pathological tissues, making it a vital tool for accurate diagnosis, and enhancing physicians’ ability to detect lesions with better precision. However, obtaining HR MRI images in practice is often challenging due to hardware limitations, extended scan durations, and patient discomfort. Super-resolution (SR) techniques have been developed to recover HR image from LR image. However, capturing and integrating local and global features remains a significant challenge, as many approaches inadequately model the complex contextual correlations across multiple scales thereby degrading reconstruction quality. To address these limitations, we propose an …

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Modelling Of Competing Compensation And Excess Revenue Sharing In Project-Based Ppp Contracts: Machine Learning And Real Option Approaches, Lykeang Sorin Jan 2024

Modelling Of Competing Compensation And Excess Revenue Sharing In Project-Based Ppp Contracts: Machine Learning And Real Option Approaches, Lykeang Sorin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Public Private Partnership (PPP) is now considered as a very common approach for the delivery of infrastructure projects, especially in developing countries in which fiscal budgets are limited. Most PPP projects are usually implemented as project-based, connecting existing infrastructure projects. However, transportation infrastructure projects as a whole work as a network of systems such as highway systems and mass rail transit (MRT) systems. Currently, the project-based approach to PPP implementation has created two unintended consequences: (1) fragmentation of the systems and (2) non-compete clause in PPP contracts preventing new development that may affect the future revenues of the concessionaire. The …

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A High-Gain Wideband Antenna Employing Novel Partial Reflective Surfaces, Mia Maria Ulfah Jan 2024

A High-Gain Wideband Antenna Employing Novel Partial Reflective Surfaces, Mia Maria Ulfah

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this dissertation, different partially reflective surfaces (PRS) are investigated to improve the gain and bandwidth of a Fabry–Perot cavity (FPC) antenna for wireless local-area network (WLAN) and vehicle-to-vehicle (V2V) communication applications. Each of the proposed PRSs has the phase of a reflection coefficient that increases with frequency. This property of the PRS is required for a broadband characteristic of the FPC antenna, which is desirable for the intended applications. A U-shaped microstrip patch antenna (MPA) with a parasitic rectangular patch is used as a feed antenna. It is designed for operation in the WLAN and V2V frequency bands. The …

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Development Of Calcium Oxide Sorbent From Waste Natural Materials For Co2 Capture, Muhammad Dody Isnaini Jan 2024

Development Of Calcium Oxide Sorbent From Waste Natural Materials For Co2 Capture, Muhammad Dody Isnaini

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to develop calcium oxide (CaO) sorbents for carbon oxide (CO2) capture by using various waste natural materials: eggshells, crab shells, and green mussel shells. These natural materials were used as precursors for the synthesis of CaO sorbents using the citric acid-assisted sol-gel method. Various characterization techniques, including N2 physisorption, XRD, XRF, CO2-TPD, TG/DTG, and FE-SEM, were performed to assess the physicochemical and thermal properties of the synthesized sorbents. The sorbent is investigated for its CO2 adsorption and recycle ability, as it has been a major issue for large-scale deployment of cyclic CO2 capture technology. This study also …

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Development Of Porous Poly(Methylmethacrylate) Beads For Toxic Cytokine Removal Application, Nutchanon Putthabucha Jan 2024

Development Of Porous Poly(Methylmethacrylate) Beads For Toxic Cytokine Removal Application, Nutchanon Putthabucha

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sepsis is a vital cause of death globally, primarily due to the uncontrolled secretion of cytokines that disrupt homeostasis. Hemoperfusion is an extracorporeal blood purification technique to treat sepsis that is uncomplicated and effective. The adsorbent material is the essence part of this technique. Since it has to direct contact with blood, the material requires necessary properties, including hemocompatibility, biocompatibility, mechanical stability, etc. Here in this thesis, we developed a new adsorbent material for hemoperfusion using PMMA beads suspension polymerization. Five different porogens, including ethyl acetate, tributyrin (short-chain triglycerides), MCT oil (medium-chain triglyceride), soybean oil (long-chain triglyceride), and toluene were …

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Investigation Of Molecular Interactions In Electrocatalysis Using Atomic Force Microscopy, Parivat Phiphatbunyabhorn Jan 2024

Investigation Of Molecular Interactions In Electrocatalysis Using Atomic Force Microscopy, Parivat Phiphatbunyabhorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Electrocatalysis at the nanoscale is fundamentally governed by molecular interactions, but these processes remain poorly understood due to their difficulty to directly investigate and their complex nature. In this study, atomic force microscopy (AFM)-based force spectroscopy is employed to investigate interfacial forces and reactivity in two representative systems: the electrochemical deterioration and healing of Au nanothin films on n-type silicon and the electrocatalytic reduction of MEA-CO2 adduct on Cu electrocatalysts. In the Au nanothin film system, observing that surface degradation is mediated by anionic cluster interactions and modulated by intrinsic band bending and surface energy effects. Remarkably, 20-nm Au films …

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Leveraging Gpt-4 For Thai Land And Building Tax Calculation In The Bangkok Area, Sadanan Arsaibun Jan 2024

Leveraging Gpt-4 For Thai Land And Building Tax Calculation In The Bangkok Area, Sadanan Arsaibun

Chulalongkorn University Theses and Dissertations (Chula ETD)

This paper explores the application of large language models (LLMs), particularly GPT-4, in the context of Thai land and building tax computation. We address challenges arising from the complexity of Thai tax regulations, the scarcity of Thai-language training data, and the structured, multi-variable nature of tax computation tasks. To enhance model performance, we employ few-shot prompting, decomposition-based reasoning, and retrieval-augmented generation (RAG). We further introduce a JSON-style output format to support structured conversational interactions, allowing the model to identify missing user inputs and guide data collection. A secondary o3-mini pass is used as an answer verifier, helping to assess the …

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Design And Multi-Objective Optimization Of Methanol Reforming, High-Temperature Proton Exchange Membrane Fuel Cell And Organic Rankine Cycle Integrated System, Supawat Taweekayujan Jan 2024

Design And Multi-Objective Optimization Of Methanol Reforming, High-Temperature Proton Exchange Membrane Fuel Cell And Organic Rankine Cycle Integrated System, Supawat Taweekayujan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The growing demand for electricity across all sectors has led researchers to focus on developing advanced electric generation technologies that offer high performance and are environmentally friendly. This study presents the design and multi-objective optimization of an integrated system combining sorption-enhanced chemical looping reforming of methanol (SECL-OSRM), high-temperature proton exchange membrane fuel cells (HT-PEMFCs), and a Recuperative-Regenerative Organic Rankine Cycle (RR-ORC). The hybrid system was simulated using Aspen Plus, focusing on energy, exergy, and exergoeconomic analyses. Sensitivity analyses of SECL-OSRM and ORC subsystems were performed to identify optimal operating conditions and working fluids. A Box-Behnken design of experiments approach generated …

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An Attention-Guided Image Super-Resolution For Scene Text, Tithnorakneath Em Jan 2024

An Attention-Guided Image Super-Resolution For Scene Text, Tithnorakneath Em

Chulalongkorn University Theses and Dissertations (Chula ETD)

Scene Text Image Super-Resolution (STISR) is crucial in enhancing text recognition for low-resolution images, often degraded due to environmental and device limitations. While many existing STISR approaches leverage super-resolution techniques to refine image quality, they frequently need specialized mechanisms to extract text-specific features. Most existing methods were based on feature extraction methods that missed critical details, such as edges and text-background contrasts, that are usually important for recognition. In this work, we propose a new feature extraction method that uses Channel Attention and Spatial Attention mechanisms to emphasize features related to text, namely edges, contours, and spatial alignment. We add …

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Uv-Vulcanized Natural Rubber Grafted With Methyl Methacrylate For Production Of Ultrafine Fully Vulcanized Natural Rubber Powder, Torntawat Kiratiphongwut Jan 2024

Uv-Vulcanized Natural Rubber Grafted With Methyl Methacrylate For Production Of Ultrafine Fully Vulcanized Natural Rubber Powder, Torntawat Kiratiphongwut

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aimed to develop ultrafine fully vulcanized powdered natural rubbers (UFPNRs). The preparation process began with grafting methyl methacrylate (MMA) monomers onto natural rubber particles, followed by UV irradiation using an acrylate-based coagent and a photoinitiator. The final product was dried using a spray-drying technique. The successful grafting of MMA onto the natural rubber particles was confirmed using Fourier-transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). At a monomer concentration of 15 parts per hundred parts of dry rubber weight (phr), the highest grafting efficiency of 89 ± 0.7% was achieved. The research investigated the use of acrylate …

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Efficacy Of Reticulocyte Hemoglobin Equivalent-Guided Versus Transferrin Saturation-Guided Iron Supplement Protocol In Hemodialysis Patients: A Cluster Randomized Controlled Trial, Chalermchon Suttaluang Jan 2024

Efficacy Of Reticulocyte Hemoglobin Equivalent-Guided Versus Transferrin Saturation-Guided Iron Supplement Protocol In Hemodialysis Patients: A Cluster Randomized Controlled Trial, Chalermchon Suttaluang

Chulalongkorn University Theses and Dissertations (Chula ETD)

BackgroundIron deficiency increases cardiovascular risk and all-cause mortality in hemodialysis patients. However, standard diagnostic tests, serum ferritin and transferrin saturation (TSAT), have limitations and are costly. Reticulocyte hemoglobin equivalent (RET-He) is a novel, less expensive marker for diagnosing iron deficiency. This study aimed to assess the non-inferiority of RET-He-guided intravenous (IV) iron supplementation compared with TSAT-guided supplementation in hemodialysis patients. MethodsA total of 138 hemodialysis patients were randomized into TSAT-guided (n = 68) and RET-He-guided (n = 70) groups. Both groups received intravenous iron according to a prespecified protocol. The primary outcome was the erythropoietin resistance index (ERI) at the …

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Cost-Utility Analysis And Dosimetric Comparison Of Proton Beam Therapy And X-Ray Beam Therapy In Pediatric Medulloblastoma In Thailand, Chonnipa Nantavithya Jan 2024

Cost-Utility Analysis And Dosimetric Comparison Of Proton Beam Therapy And X-Ray Beam Therapy In Pediatric Medulloblastoma In Thailand, Chonnipa Nantavithya

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The benefits of proton beam therapy (PBT) are evident in pediatric cancer, as survivors face long-term radiation-related side effects and lifetime costs. However, the higher cost of PBT presents a challenge, particularly in middle-income countries, like Thailand. This study analyzed dose to organs at risk (OARs), excess-relative risk (ERR) of cardiac mortality and the cost-utility of PBT versus X-ray beam therapy (XRT) for medulloblastoma in the context of Thailand. Methods: In the dosimetric phase, craniospinal irradiation (CSI) plans were generated using three-dimensional conformal radiotherapy (3D-CRT), volumetric modulated arc therapy (VMAT), and PBT. Vertebral body reduced dose (VBR)-CSI contouring was …

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Antenatal Dexamethasone For Late Preterm Deliveries: A Randomized Controlled Trial, Hoang Minh Chau Le Jan 2024

Antenatal Dexamethasone For Late Preterm Deliveries: A Randomized Controlled Trial, Hoang Minh Chau Le

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Antenatal corticosteroids (ACS) have been found to have beneficial effects on neonatal lung function, reducing mortality and morbidities, especially in very preterm infants. The World Health Organization recommends ACS for women at risk of preterm birth from 24 to 34 weeks of gestation; however, specific recommendations ACS use in late preterm deliveries remain lacking. This study aimed to assess the effect of antenatal dexamethasone on reducing the need for respiratory support, neonatal morbidities and mortality, NICU admission, and length of hospital stay in late preterm infants. Methods: This single-centre, parallel group, open-label randomized controlled trial enrolled women with singleton …

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The Efficacy And Palatability Of Developed Polyethylene Glycol-Based Formula For Children With Functional Constipation, Duc Long Tran Jan 2024

The Efficacy And Palatability Of Developed Polyethylene Glycol-Based Formula For Children With Functional Constipation, Duc Long Tran

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Polyethylene glycol (PEG) is the first-line treatment for childhood functional constipation (FC). Inactive ingredients like sweeteners and flavors may improve the palatability of PEG, leading to good compliance and favorable treatment outcomes. This study aimed to compare the efficacy, safety and palatability of a developed PEG-based formula (PEG-Chula) with the commercial formula available in Thailand for treating childhood FC.Method: This randomized controlled trial enrolled children aged 6 months to 18 years with FC diagnosed by the Rome IV criteria. Participants were randomly assigned (1:1) to receive PEG-Chula (four flavors: strawberry, lychee, green apple, lychee-rose) or Forlax (orange-grapefruit flavor) for …

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A Pragmatic, Open-Label, Randomized Controlled Trial Of Ringer’S Lactate Solution Versus Normal Saline Plus 5% Dextros Solution On Metabolic Acidosis In The First Week Of Post-Operative Period Of Kidney Transplantation, Kornrawee Sawasdichai Jan 2024

A Pragmatic, Open-Label, Randomized Controlled Trial Of Ringer’S Lactate Solution Versus Normal Saline Plus 5% Dextros Solution On Metabolic Acidosis In The First Week Of Post-Operative Period Of Kidney Transplantation, Kornrawee Sawasdichai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Backgroud: Post-operative fluid management in kidney transplantation (KT) has shifted from Normal Saline Solution (NSS) to balanced crystalloid solutions due to NSS associated with hyperchloremic metabolic acidosis and higher rates of delayed graft function(DGF). This study aimed to compare the efficacy of NSS+D5W versus Ringer’s Lactate Solution (RLS) in preventing metabolic acidosis in KT recipients during the first post-operative week.Methods: An open-label, randomized controlled trial conducted at King Chulalongkorn Memorial Hospital, included adult KT recipients from both living and deceased donors. Patients were randomized to receive either NSS+D5W or RLS as the post-operative IV fluid. Exclusion criteria were multiorgan transplantation …

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Effect Of Vancomycin Loading Dose On Auc0-24 Target Attainment In Pediatric Sepsis Patients, Kritsaporn Sujjavorakul Jan 2024

Effect Of Vancomycin Loading Dose On Auc0-24 Target Attainment In Pediatric Sepsis Patients, Kritsaporn Sujjavorakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Sepsis is a leading cause of mortality in hospitalized children, with a significant proportion of deaths occurring within the first 24-48 hours post-diagnosis. Early management, including appropriate antibiotic administration, is crucial. Vancomycin, often used for multidrug-resistant pathogens, presents dosing challenges due to altered pharmacokinetics in sepsis.Objectives: This study aims to evaluate the accuracy of first-order pharmacokinetic equations for calculating the area under the concentration-time curve (AUC) of vancomycin in pediatric sepsis patients and to assess the efficacy of a loading dose strategy in achieving target AUC0-24.Methods: The study was conducted in two sections:1. Evaluation of First-Order Pharmacokinetics Analytic Equations: …

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Exploring The Skin Microbiome Of Alopecic Cynomolgus Macaques (Macaca Fascicularis) Based On Oxford Nanopore Technologies, Natthanit Phokkhasub Jan 2024

Exploring The Skin Microbiome Of Alopecic Cynomolgus Macaques (Macaca Fascicularis) Based On Oxford Nanopore Technologies, Natthanit Phokkhasub

Chulalongkorn University Theses and Dissertations (Chula ETD)

Alopecia or hair loss in captive non-human primates (NHPs) such as cynomolgus macaques is a major concern of animal welfare in many primate facilities. The purpose of this study is to investigate the association between alopecic and healthy skin microbiome in cynomolgus macaques. This study included skin swab samples (head, arm, leg, ventral, and dorsal areas) collected from 33 healthy and 50 alopecic macaques housed at the NPRCT-CU. LEfSe analysis revealed the significant bacteria found in multiple areas of the alopecic group, including P. copri and L. animalis. The significant fungi found in double areas (arm-dorsal, dorsal-head, and leg-ventral) of …

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Combining Ultrasound Of Inferior Vena Cava And Laboratory Markers To Enhance Diagnosis Of Euvolemic Hyponatremia In Siad, Natthasit Suphavejkornkij Jan 2024

Combining Ultrasound Of Inferior Vena Cava And Laboratory Markers To Enhance Diagnosis Of Euvolemic Hyponatremia In Siad, Natthasit Suphavejkornkij

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The diagnosis of Syndrome of Inappropriate Antidiuresis (SIAD) relies heavily on clinical assessment of euvolemia and laboratory parameters, which are often influenced by various confounding factors. Accurate volume status assessment remains a challenge.Objective: To evaluate the diagnostic performance of combining Inferior Vena Cava Collapsibility Index (IVC CI) and Body Composition Monitoring (BCM) in detecting euvolemic status to enhance SIAD diagnosis.Methods: We conducted a prospective cross-sectional study on 32 patients with hyponatremia (serum sodium 115–134 mmol/L) at King Chulalongkorn Memorial Hospital from January to February 2025. All patients underwent physical examination, laboratory testing, IVC ultrasonography, and BCM. The final SIAD …

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Thai Version Of The Brief Assessment Of Social Skills-Dementia (Bass-D Th): A Validation And Functional Near-Infrared Spectroscopy Study, Pornsinee Laisathit Jan 2024

Thai Version Of The Brief Assessment Of Social Skills-Dementia (Bass-D Th): A Validation And Functional Near-Infrared Spectroscopy Study, Pornsinee Laisathit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Brief Assessment of Social Skills – Dementia (BASS-D) was developed to provide a concise and effective measure of social cognition across four domains. This study aimed to validate the Thai version of BASS-D (BASS-D TH), examining its psychometric properties and factors associated with BASS-D TH, as well as anatomical correlates using functional Near-Infrared Spectroscopy (fNIRS). BASS-D was forward and back -translated between Thai and English language. Minor modifications were made to enhance cultural replicability. The BASS-D TH was administered to 28 elderly controls and 13 dementia patients. Age and number of years in formal education were statistically different (t=-3.67, …

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Epigenetic Regulation Of Cancer Testis Antigens In Hepatocellular Carcinoma, Rinrada Klankajorn Jan 2024

Epigenetic Regulation Of Cancer Testis Antigens In Hepatocellular Carcinoma, Rinrada Klankajorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatocellular carcinoma (HCC) represents one of the most common causes of cancer-related death worldwide, with few available treatment options. Cancer-testis antigens (CTAs), notably from the MAGE gene family, have opened new possibilities for improving immunotherapy in HCC due to their tumor-specific expression and high immunogenicity. However, the mechanisms regulating MAGE gene expression are largely unknown. This study explored mechanisms controlling the expression of MAGE-A3 and MAGE-C2. We utilized HCC organoid cultures derived from patient HCC tissues known to represent cancer epigenetic status more accurately than cell lines to study the MAGE gene family expression patterns and promoter methylation patterns. Our …

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Incidence, Risk Factors, And Outcome Of Anti-Tuberculosis Drug-Induced Hepatotoxicity In People With And Without Hiv In Thailand And The Philippines, Ryan Christopher Atuel Jan 2024

Incidence, Risk Factors, And Outcome Of Anti-Tuberculosis Drug-Induced Hepatotoxicity In People With And Without Hiv In Thailand And The Philippines, Ryan Christopher Atuel

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Anti-tuberculosis drug-induced hepatotoxicity (DIH) is a common complication among people living with HIV (PLWH), potentially leading to treatment interruptions. Objective: To determine the incidence of DIH and identify risk factors in Thai and Filipino PLWH on tuberculosis (TB) treatment, compared with those with TB mono-infection. Materials and Methods: We conducted a cohort study of Thai and Filipino adults with active TB using retrospective data from Thailand (2000–2024) and prospective data from the Philippines (2024). Eligible participants had AST/ALT results at TB treatment initiation and follow-up. DIH was defined as AST or ALT ≥3 times the upper limit of normal. …

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Evaluating The Severity Of Disc Herniation : A Comparative Analysis Of Standing Spine Radiographs And Mri Findings, Suttinont Surapuchong Jan 2024

Evaluating The Severity Of Disc Herniation : A Comparative Analysis Of Standing Spine Radiographs And Mri Findings, Suttinont Surapuchong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: The degree of spinal canal compromise in lumbar disc herniation (LDH) significantly influences treatment outcomes. Although magnetic resonance imaging (MRI) remains the gold standard for assessing LDH severity, limited access in primary and secondary care settings can delay diagnosis and referral. This study aimed to determine whether radiological parameters observed on standing spine radiographs can predict the severity of LDH and support timely referral for advanced care. Methods: In this retrospective cross-sectional study, patients diagnosed with LDH who underwent both standing whole-spine radiographs and lumbar MRI between June 2014 and January 2024 were included. Radiographic parameters evaluated included disc …

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