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Synthesis And Evaluation Of Novel Membrane Type 1 Matrix Metalloproteinase (Mt1-Mmp) Inhibitors, Nicholas Borges Jan 2024

Synthesis And Evaluation Of Novel Membrane Type 1 Matrix Metalloproteinase (Mt1-Mmp) Inhibitors, Nicholas Borges

Harriet L Wilkes Honors College Theses 2020 - Present

Membrane type 1 matrix metalloproteinase (MT1-MMP)/(MMP-14) is a type I transmembrane metalloproteinase involved in degradation of extracellular matrix (ECM) and non-ECM substrates. MT1-MMP facilitates cell migration, and is associated with multiple physiological processes, such as morphogenesis, skeletal development, and wound healing. However, MT1-MMP overexpression causes cancer cell invasion, metastasis, and growth. Therefore, MT1-MMP activities should be regulated either through endogenous tissue inhibitors of MMPs (TIMPs) or novel synthetic MT1-MMP inhibitors. The specific aim of this thesis work is the synthesis and evaluation of novel MT1-MMP C6 and C12 hit inhibitors obtained from one-bead one-compound (OBOC) libraries in order to aid …

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Natural Or Noxius: An Extensive Look Into Greenwashing And Other Deceptive Marketing Techniques, Morgan Balsley Jan 2024

Natural Or Noxius: An Extensive Look Into Greenwashing And Other Deceptive Marketing Techniques, Morgan Balsley

Harriet L Wilkes Honors College Theses 2020 - Present

This thesis examines greenwashing and other deceptive marketing techniques within the two areas of environmental concern and healthy living. In recent years, there has been an increase in consumer desire for sustainably sourced and natural ingredients. In order to keep up with the shift in demand, companies have implemented new strategies to project an image of ethical practices and clean products. However, sometimes these claims can be deceptive. This paper breaks down fraudulent marketing techniques into three categories: Misleading Imagery, Wording, and Certifications; Deceit Through Lack of Transparency and Informational Context; and Diversion. I provide examples of companies that employ …

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Ketamine's Therapeutic Potential: A Literature Review, Mya Arscott Jan 2024

Ketamine's Therapeutic Potential: A Literature Review, Mya Arscott

Harriet L Wilkes Honors College Theses 2020 - Present

The demand for alternative treatment for depressive disorders has increased in recent years. Our clinical understanding of treatment-resistant depression (TRD) has evolved, highlighting the need for different treatments to develop for this subgroup of depression. Treatment-resistant depression is defined as the absence of significant improvement in depressive symptoms despite standard therapy. Considerable improvement in depressive symptoms can seen in an improvement of functioning in everyday activities and a decrease in negative symptoms such as loss of interest, feelings of worthlessness, etc. Ketamine's rapid method of action has been shown to be notably beneficial for individuals with TRD. Research has proven …

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Semi-Complemented Group Rings, James Branca Jan 2024

Semi-Complemented Group Rings, James Branca

Harriet L Wilkes Honors College Theses 2020 - Present

Within mathematics, the field of algebra focuses primarily on preserving symmetry and structure within a set. This thesis focuses on a given group G over a (commutative) ring R, referred to as the group ring R[G]. Elements within R[G] are finite formal sums of elements of G with coefficients from R. A class of reduced rings that generalizes integral domains is that of complemented rings. We will discuss new subcategories of complemented rings: semi-complemented and almost complemented rings. Since R[G] is a ring itself, we would like to find when R[G] is complemented or perhaps only semi or almost complemented. …

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Disparities In Punishment For Drunk Driving And Using A Cellphone While Driving, Jessica Cordiner Jan 2024

Disparities In Punishment For Drunk Driving And Using A Cellphone While Driving, Jessica Cordiner

Harriet L Wilkes Honors College Theses 2020 - Present

In the United States, driving with a blood alcohol concentration (BAC) of at least .08% is regarded as one of the most serious offenses threatening road safety; meanwhile, driving while using a cell phone (CUD) is considered to be significantly less serious. Whether or not an accident occurs, the BAC driver may face punishment, including fines, license revocation, jail time, probation, and more, while the CUD driver merely faces fines and points against their license at most. Both offenses risk harm to others, but only the BAC driver's offense gets taken seriously. I argue that assuming both are equally culpable …

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You Feel What You Eat: Exploring How Culture And Food Access May Shape Mental Health Via The Gut Microbiome, Drew Burgess Jan 2024

You Feel What You Eat: Exploring How Culture And Food Access May Shape Mental Health Via The Gut Microbiome, Drew Burgess

Harriet L Wilkes Honors College Theses 2020 - Present

Previous research implicates the gut-brain axis in mental health, but factors such as cultural diet and other circumstances that influence the gut-brain axis have not been extensively studied. This thesis aims to investigate cultural factors and other factors, including seasonal and economic conditions, that may influence diet and therefore, the gut microbiota, and in turn, the gut-brain axis. To explore this connection, the relationship between components of diet and changes in the gut microbiota composition was reviewed. To understand how those factors may interact to impact anxiety and depression via the gut-brain axis, a host of influences should be considered, …

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Cell-Type-Specific Consolidation Of Learned Motor Memories In The Neocortex, Rebecca Dicicco Jan 2024

Cell-Type-Specific Consolidation Of Learned Motor Memories In The Neocortex, Rebecca Dicicco

Harriet L Wilkes Honors College Theses 2020 - Present

Motor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill acquisition. This project aims to explore how the brain consolidates the acquired motor skill as a long-term memory. We hypothesize that following motor learning, CaMKII in PT, but not IT, cells activates the …

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“Biological Warfare: Can A War Be Justly Fought Using Biological Weapons?”, Gabrielle Emilio Fagundes Jan 2024

“Biological Warfare: Can A War Be Justly Fought Using Biological Weapons?”, Gabrielle Emilio Fagundes

Harriet L Wilkes Honors College Theses 2020 - Present

Biological agents and toxins have been used as weapons offensively as early as 1320 BCE. Modern ability to manipulate and control biological materials has raised concerns as to how wars will be fought in the future. The Geneva Protocol of 1925 and the subsequent Geneva Conventions have clearly determined biological warfare as unethical and illegal due to the devastating effects it has on both combatants and noncombatants. The International Humanitarian Laws, based on the fourth Geneva Convention, are used as guidelines for fighting just and legal wars. Although the use of biological weaponry has been banned for almost a century, …

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Genetic Doping, Enhancement, And Therapy: An Ethical Analysis In The Context Of Competitive Sport, Damon Farrell Jan 2024

Genetic Doping, Enhancement, And Therapy: An Ethical Analysis In The Context Of Competitive Sport, Damon Farrell

Harriet L Wilkes Honors College Theses 2020 - Present

In the realm of sports, a domain characterized by skill, competition, and entertainment, the consensus stands firm—cheating is unequivocally wrong. Violations extend beyond the traditional realm of illicit substances like stimulants and steroids to encompass emerging technological advancements, notably gene doping. Gene doping involves the utilization of genetic-altering technology to augment human performance, introducing a new dimension to the ethical discourse surrounding sports. Despite its designation as a banned practice by numerous sports agencies, there are scenarios where the deployment of this technology warrants consideration and even ethical approval. This analysis delves into the prospects of gene doping, elucidates fundamental …

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Hearts That Beat The Odds: An Analysis Of The Fontan Procedure, Joseph Farrell Jan 2024

Hearts That Beat The Odds: An Analysis Of The Fontan Procedure, Joseph Farrell

Harriet L Wilkes Honors College Theses 2020 - Present

This thesis delves into the Fontan cardiovascular procedure, a specialized intervention for congenital heart defects. Through historical analysis, preparatory protocols, statistical data, and long-term effects, this paper offers a comprehensive examination of this surgical procedure. It traces its origins, breakthroughs, and milestones, from diagnosis to detailed planning and execution. With approximately 50,000 worldwide cases, statistical analysis explores success rates and demographics. Recognizing its lifelong impact, the research examines postoperative complications, quality of life, and ongoing healthcare needs. This comprehensive scrutiny extends to long-term implications. Additionally, there is a supplementing website conveniently disseminating insights and factual information about the Fontan procedure, …

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Elyrion's Harmony: A 2d Video Game, Jovan Fuller Jan 2024

Elyrion's Harmony: A 2d Video Game, Jovan Fuller

Harriet L Wilkes Honors College Theses 2020 - Present

Elyrion's Harmony' is a 2D side-scrolling game in the fantasy genre. It takes place on the planet Elyrion. Elyrion is home to multiple countries, including Earth, Water, Air, and Fire. The player plays as Lyra, a citizen of Earth who witnesses her village's destruction by the malevolent sorcerer, Malachor. Seeking to tear the world asunder, Malachor's chaos disrupts the once-harmonious planet. As Lyra, players navigate diverse landscapes and battle elemental challenges to save her world.

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Feminismo Lésbico Y Movimiento Queer En España: Los Casos De Victorina Durán (1899-1993) Y Gloria Fuertes (1917-1998), Daniela Garcia-Moreno Jan 2024

Feminismo Lésbico Y Movimiento Queer En España: Los Casos De Victorina Durán (1899-1993) Y Gloria Fuertes (1917-1998), Daniela Garcia-Moreno

Harriet L Wilkes Honors College Theses 2020 - Present

Este estudio examina cómo las obras literarias y las figuras públicas de Victorina Durán y Gloria Fuertes han influido significativamente en discurso sobre el género, la sexualidad e la identidad queer en España. El estudio enfatiza particularmente los desafíos históricos y socioculturales que enfrentan estas autoras y su papel pionero en la articulación de la visibilidad y los derechos de las lesbianas. La tesis analiza las experiencias queer de estas dos mujeres en el contexto de la Segunda República, la dictadura de Francisco Franco y La Movida Madrileña. También aborda el impacto que tuvo su literatura en la comunidad queer.

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Predicted Spread In The Southeastern Us Of The Non-Native Lizard, Agama Picticauda, Based On Current And Future Climate, Sebastian Giddings Jan 2024

Predicted Spread In The Southeastern Us Of The Non-Native Lizard, Agama Picticauda, Based On Current And Future Climate, Sebastian Giddings

Harriet L Wilkes Honors College Theses 2020 - Present

Peters’s rock agama, Agama picticauda, is a West African lizard first observed in South Florida in 1975. It has since spread through much of the state and into southernmost Georgia. To better understand the potential spread of this invasive species in the southeastern US, I used Maxent species distribution models with native and non-native occurrences for A. picticauda with current and future bioclimatic variables. The models suggest that by 2100, the species could spread through all of Florida, much of Georgia, South Carolina, and North Carolina, and southern parts of Alabama, Mississippi, Louisiana, and Virginia.

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Precarious Gardening: The Influence Of Victory Gardens In Wwii And Their Relevance With Marketing Sustainable Practices Today, Katherine Mali Hanner Jan 2024

Precarious Gardening: The Influence Of Victory Gardens In Wwii And Their Relevance With Marketing Sustainable Practices Today, Katherine Mali Hanner

Harriet L Wilkes Honors College Theses 2020 - Present

This thesis explores the concept of precarity in relation to sustainability efforts within the United States through a comparison of victory gardens during World War II and the contemporary garden movement in the twenty-first century. Victory gardens were used as a means to promote civilian action in war efforts to supplement food rationing and contemporary gardening has encouraged the average homeowner to grow backyard gardens in the name of sustainability. Both demonstrate how the marketing strategies during perceived crises have utilized precarity rather than progress to propel action among the common man. While some tactics employed then still remain useful …

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A Study To Elucidate The Interaction Of Membrane-Type 1 Matrix Metalloproteinase (Mt1-Mmp) And Hypoxia-Inducible Factor 1-Alpha (Hif-1Α) In Pancreatic Cancer, Michelle E. Gras Jan 2024

A Study To Elucidate The Interaction Of Membrane-Type 1 Matrix Metalloproteinase (Mt1-Mmp) And Hypoxia-Inducible Factor 1-Alpha (Hif-1Α) In Pancreatic Cancer, Michelle E. Gras

Harriet L Wilkes Honors College Theses 2020 - Present

Pancreatic cancers are difficult to treat with a 13% survival rate. Factors such as hypoxic niches within the cancer promote drug resistance, while enzymes such as membrane-type 1 matrix metalloproteinase (MT1-MMP) are linked to disease etiology. MT1-MMP’s transmembrane region is implicated in cancer invasion and metastasis. However, little is known about the cytoplasmic tail (MT1-MMP-CT). Recent studies have linked MT1-MMP-CT and the transcription factor, hypoxia-inducible-factor-1-subunit-alpha (HIF-1α); a transcription factor that is stable only under hypoxia. This study uses flow cytometry to quantify the co expression of HIF-1α and MT1-MMP-CT among human pancreatic cell lines, under both normoxia and hypoxia. This …

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Beyond Legal Borders: Applying Predictive Modeling To Affirmative Asylum Decisions Using Economic And Political Conditions, Johann Alexander Cifuentes Jan 2024

Beyond Legal Borders: Applying Predictive Modeling To Affirmative Asylum Decisions Using Economic And Political Conditions, Johann Alexander Cifuentes

Harriet L Wilkes Honors College Theses 2020 - Present

The present study investigates the objectivity of the current affirmative asylum approval decision-making process in the United States. It provides a brief history of asylum law and the relevant statutes that determine an applicant’s eligibility to be granted asylum. This study will show that the current strict criteria to be granted affirmative asylum in the United States does not reflect the reality of the decision-making process done by asylum officers and adjudicators. Using affirmative asylum approval data by country from the Department of Homeland Security alongside computational libraries found in Python 3, the study will perform correlation and ordinary least …

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Development And Testing Of A Small Wave Energy Converter For Numerical Simulation Validation, Westin Johnson Jan 2024

Development And Testing Of A Small Wave Energy Converter For Numerical Simulation Validation, Westin Johnson

Harriet L Wilkes Honors College Theses 2020 - Present

Wave energy converters (WECs) are marine renewable energy devices designed to harness the potential and kinetic energy present in waves and convert it into electrical energy. This energy can then be stored or directed to power coastal cities or offshore installations. This thesis discusses a small-scale (~2m diameter) wave energy converter developed to gather open-water performance data for validating the numerical simulation of a 4-body oscillating body type WEC design. This WEC underwent numerical simulation using both WEC-Sim and ProteusDS, and these results were subsequently compared to the in-water testing data to validate the accuracy of the simulation. This research …

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The Acute Effects Of Graphene Nanoflakes On Whole-Cell Cholesterol, Ritvik Kesharaju Jan 2024

The Acute Effects Of Graphene Nanoflakes On Whole-Cell Cholesterol, Ritvik Kesharaju

Harriet L Wilkes Honors College Theses 2020 - Present

Graphene is a novel nanomaterial with great potential in biomedicine owing to its high electron mobility, thermal conductivity, and mechanical strength. In biological applications, graphene often makes direct contact with the plasma membrane and likely affects cellular function. The lack of understanding about graphene-plasmalemma interaction inspired this mechanistic study. Based on published work from our lab about graphene’s chronic effects on cell growth, we used graphene nanoflakes (GNFs) and examined their acute effects in astrocytes. Our tests show that GNFs readily insert into the plasmalemma, focally enrich membrane cholesterol (mChol), stabilize surrounding membrane, and promote membrane protein activity and transmembrane …

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Faith And Governance: Balancing Religious Expression And Government Neutrality In Democratic Republics, Kathaleen Kelly Jan 2024

Faith And Governance: Balancing Religious Expression And Government Neutrality In Democratic Republics, Kathaleen Kelly

Harriet L Wilkes Honors College Theses 2020 - Present

As nations grow more diverse in religious beliefs, the debate intensifies over what, if any, public religious displays governments should allow. Some argue that the separation of church and state does not hinder the state and religious institutions from coexisting peacefully, thereby allowing the public display of some religious symbols. In contrast, others firmly believe in preventing overlap between the two and that public displays of religion are inappropriate. I argue that in democratic republic nations with laws upholding the separation of church and state, the government should not allow religious displays on public, government-owned land by examining John Rawls’ …

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Expanding Meditation Options: Freeze Frame Meditation And Decision Making, Emerson Lee Jan 2024

Expanding Meditation Options: Freeze Frame Meditation And Decision Making, Emerson Lee

Harriet L Wilkes Honors College Theses 2020 - Present

To expand the variety of meditation types researched and available for use in improving mental health, this study examined whether Freeze Frame meditation, a lesser-studied meditation type, increases decision-making capabilities and wellbeing. We hypothesized that, compared to an active control group, participants engaging in Freeze Frame meditation would self-report increased wellbeing and decreased stress, as well as would rate the answers they received during the meditation to be impactful. Our hypothesis was partially supported by our results, which indicated Freeze Frame meditation increased self-reported wellbeing between pre-meditation and post-meditation time points but did not have an effect on decision-making.

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Colonial Legacies, Modern Woes: A Study Of Guatemala’S Battle With Corruption, Emma N. Solórzano Leonardo Jan 2024

Colonial Legacies, Modern Woes: A Study Of Guatemala’S Battle With Corruption, Emma N. Solórzano Leonardo

Harriet L Wilkes Honors College Theses 2020 - Present

Utilizing data sets from the Corruption Perceptions Index and Latino Barometer, this thesis investigates the persistent corruption within the Guatemalan government, examining the influence of colonial and liberal legacies and their continuation through the Guatemalan Civil War in perpetuating systemic corruption and impunity. It explores the rise of a progressive anti-establishment presidential ticket in 2023, despite oligarchic opposition, emphasizing the role of resilient democratic values in shaping election outcomes. By detailing the fluctuations of corruption levels in relation to regime changes from 2012-2023, this study underscores the impact of anti-corruption efforts, such as the International Commission Against Impunity in Guatemala …

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Loot Box…Gambling?, Carolyn Mas Jan 2024

Loot Box…Gambling?, Carolyn Mas

Harriet L Wilkes Honors College Theses 2020 - Present

The ‘loot box’ has become a prevalent monetization method in the gaming industry where users receive a randomly selected in-game reward after paying a fee. The items in these boxes can range from cosmetic items to valuable tools that help players gain a competitive advantage. This mechanism is akin to gambling because players can utilize in-game trading platforms or third-party platforms to trade in-game items for actual currency. This thesis will argue that the elements of chance, purchase, and reward involved with this mechanism exploit the same neurological reward pathways associated with gambling in a way that leaves audiences of …

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Ethical Dilemmas In Glioblastoma Patient Care: A Case Study, Laura-Lee Mc Comie Jan 2024

Ethical Dilemmas In Glioblastoma Patient Care: A Case Study, Laura-Lee Mc Comie

Harriet L Wilkes Honors College Theses 2020 - Present

This thesis investigates the ethical implications surrounding the sudden death of a 46-year-old male patient from glioblastoma, a highly aggressive brain tumor. The analysis focuses on the intricate details of the case, dissecting the events that transpired, and identifying the medical and ethical mistakes that were made. Further, this thesis critically examines the decisions made by both the healthcare professionals and the patient, and the deficiencies in diagnosis, communication, and treatment strategy in the case. Because of delayed diagnosis and inadequate treatment, the patient suffered an untimely death. By unraveling the complexities of this case, this thesis seeks to contribute …

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Power Of The Spine: The Impact Of Non-Invasive Chiropractic Care On Patients, Jaden Mekled Jan 2024

Power Of The Spine: The Impact Of Non-Invasive Chiropractic Care On Patients, Jaden Mekled

Harriet L Wilkes Honors College Theses 2020 - Present

Chiropractic care is a form of alternative medicine involving the non-invasive treatment of musculoskeletal disorders. I spent 5 months working as an intern at Spine Design Chiropractic in Jupiter, Florida. For my thesis, I observe the current state of chiropractic care, using two case studies. The details I present display the use of chiropractic care in the diagnosis and treatment of two representative cases of patients at the clinic, outlining their different care plans and their outcomes.

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Change Of Bacterial Diversity Within The Fecal Samples Of Gopherus Polyphemus For One Month, Gabrielle Ruiz Jan 2024

Change Of Bacterial Diversity Within The Fecal Samples Of Gopherus Polyphemus For One Month, Gabrielle Ruiz

Harriet L Wilkes Honors College Theses 2020 - Present

The microbiome plays a significant role in the strength of the immune system; it aids in the recovery of nutrition, is essential for the prevention of invading pathogens, and helps in the remediation of harmful toxicants. The microbiome is largely unknown, especially in reptiles like the gopher tortoise. Gopher tortoises are threatened in Florida and multiple other states. Therefore, it is important to understand how the bacterial population changes over time outside of the organism. We humanely harvested fresh feces from three gopher tortoises in the Jupiter Abacoa greenway, and left the feces in the field. We re-took samples at …

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The Enigma Of The Successful Psychopath: An In-Depth Examination, Josette Mobley Jan 2024

The Enigma Of The Successful Psychopath: An In-Depth Examination, Josette Mobley

Harriet L Wilkes Honors College Theses 2020 - Present

In this thesis, I examine three psychological characteristics – psychopathy, autism, and intelligence – and consider how they are related. Psychopathy is a condition that has long captured the public imagination. Articles and blogs are devoted to murderers with psychopathic features. Movies and TV shows have been based on real-life famous psychopaths narrating the horrible crimes they have committed. Psychopathy is a personality disorder characterized by a lack of empathy and guilt, manipulation of other people, and violent antisocial behavior. Intelligence is the ability to acquire and apply knowledge and skills. “Successful psychopaths” are those who have all the traits …

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Invictus: Nigredo & Calcinatio, Christian Soares Deoliveira Jan 2024

Invictus: Nigredo & Calcinatio, Christian Soares Deoliveira

Harriet L Wilkes Honors College Theses 2020 - Present

Invictus is a narrative virtual reality (VR) game which makes use of 16th century alchemical concepts on becoming spiritually whole. As an alchemist, the player begins their first steps in achieving The Great Work – a state of perfect being; synonymous with creating The Philosopher’s Stone. To begin, players embark into a stage called Nigredo, where the many is transmuted into one through the processes of alchemical Fire – calcination – as a method of purification. Players begin in an alchemical laboratory, learning about and preparing the first stage and process. To experience being transmuted by the power of Fire, …

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Is Airbnb Impacting Home Prices? Evidence From Fort Lauderdale, Michael Thayer Jan 2024

Is Airbnb Impacting Home Prices? Evidence From Fort Lauderdale, Michael Thayer

Harriet L Wilkes Honors College Theses 2020 - Present

Airbnb has attracted significant attention from municipal governments due to its potential to influence housing affordability. This paper assesses the role of Airbnb concentration on home prices in Fort Lauderdale from October 2021 to December 2022 using a first difference fixed effect model and data scraped from the Airbnb website via InsideAirbnb. The results from the model suggest higher Airbnb concentration leads to higher home prices. For a home priced between the 35th and 65th percentile, an additional one percentage point of Airbnb concentration causes prices to increase by 3.2 percent.

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Exploring The Relationship Between Amazon Badges And Star Ratings In Online Reviews, Trish Tran Jan 2024

Exploring The Relationship Between Amazon Badges And Star Ratings In Online Reviews, Trish Tran

Harriet L Wilkes Honors College Theses 2020 - Present

This thesis investigates the relationship between three Amazon badges (Vine Voice, Vine Customer of a Free Product, and Verified Purchase) and the star ratings. The status and incentives associated with badges pose a concern of credibility in online reviews. This thesis examines whether the Vine Voice badge and Vine Review of a Free Product badge are more likely to have higher star ratings, and whether the Verified Purchase badge is more likely to have lower star ratings. Amazon reviews on two different battery products were manually collected and parsed to extract variables relevant to the research question. An ordinal logistic …

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Could Solar Energy Be Our Future? Literary Analysis, Tyler Martin Jan 2024

Could Solar Energy Be Our Future? Literary Analysis, Tyler Martin

Harriet L Wilkes Honors College Theses 2020 - Present

As energy consumption increases, the need for an efficient, cheap-to-make, and low-maintenance power converter is increasingly sought after. Solar energy has the potential to fill all these requirements as it is not only the most abundant source of energy on the planet, but the devices themselves require little to no cost post-installation. Solar cells convert photon particles into flowing current, producing voltage by merely remaining stationary, something that fossil fuel production cannot achieve. The efficiency of these devices has drastically improved over the last 30 years, jumping from less than 10% to nearly 30%, and with some of the practices …

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