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การพัฒนาเครื่องมือปัญญาประดิษฐ์ช่วยตรวจสอบความถูกต้องตามกฎหมายของข้อมูลผลิตภัณฑ์เสริมอาหารบนแพลตฟอร์ม E-Commerce ในประเทศไทย, ชวลิน อินทร์ทอง Jan 2024

การพัฒนาเครื่องมือปัญญาประดิษฐ์ช่วยตรวจสอบความถูกต้องตามกฎหมายของข้อมูลผลิตภัณฑ์เสริมอาหารบนแพลตฟอร์ม E-Commerce ในประเทศไทย, ชวลิน อินทร์ทอง

Chulalongkorn University Theses and Dissertations (Chula ETD)

ปัจจุบันแพลตฟอร์มพาณิชย์อิเล็กทรอนิกส์มีบทบาทสำคัญในระบบสุขภาพในด้านเป็นแหล่งข้อมูลและช่องทางการเข้าถึงผลิตภัณฑ์เสริมอาหารในกลุ่มผู้บริโภคไทย แต่ขณะเดียวกันกลับพบการกระทำผิดกฎหมายเป็นจำนวนมาก วัตถุประสงค์ เพื่อพัฒนาเครื่องมือปัญญาประดิษฐ์ช่วยตรวจสอบความถูกต้องตามกฎหมายของข้อมูลผลิตภัณฑ์เสริมอาหารบนแพลตฟอร์มพาณิชย์อิเล็กทรอนิกส์ในประเทศไทย ใช้รูปแบบการวิจัยแบบผสมผสาน มีกระบวนการ 3 ระยะ ระยะที่ 1 เป็นการพัฒนาต้นแบบปัญญาประดิษฐ์ช่วยตรวจสอบความถูกต้องตามกฎหมายของข้อมูลผลิตภัณฑ์เสริมอาหารบนแพลตฟอร์มพาณิชย์อิเล็กทรอนิกส์ ระยะที่ 2 เป็นการทดสอบความไวและความจำเพาะของต้นแบบ และระยะที่ 3 เป็นการศึกษาความเห็นของผู้ใช้งานเป้าหมายต่อการนำปัญญาประดิษฐ์ไปใช้งาน ผลการวิจัย ระยะที่ 1 พบความชุกของการกระทำผิดเกี่ยวกับการจำหน่ายผลิตภัณฑ์เสริมอาหารบนแพลตฟอร์มพาณิชย์อิเล็กทรอนิกส์ที่นิยมในประเทศไทยอยู่ที่ร้อยละ 84.6 ผู้มีส่วนได้ส่วนเสียหลักมีความเห็นในการพัฒนาต้นแบบว่าควรมีการจัดการที่มาของนวัตกรรมที่น่าเชื่อถือ การเชื่อมโยงการทำงานกับผู้ให้บริการ การออกแบบให้สามารถจำแนกความผิดและรวบรวมข้อมูลส่งกลับให้ผู้เกี่ยวข้องได้ เป็นการสร้างรายได้ การสร้างแรงกดดันทางสังคม และการนำเสนอคุณค่า ในระยะที่ 2 การทดสอบต้นแบบปัญญาประดิษฐ์มีค่าความไว ร้อยละ 56.4 และความจำเพาะ ร้อยละ 89.0 ส่วนระยะที่ 3 พบว่าตัวแทนองค์ผู้ใช้เป้าหมายให้ความสนใจปัญญาประดิษฐ์ อย่างไรก็ตามควรปรับปรุงให้การจำแนกความผิดมีความซับซ้อนลดลงแต่สอดคล้องกับการนำไปใช้งานมากขึ้น กลยุทธ์ที่ควรทำคือ การสื่อสารคุณค่าของปัญญาประดิษฐ์ในส่งเสริมการค้าเชิงสร้างสรรค์ และลดความเสี่ยงทางกฎหมายมากกว่าการบังคับเชิงกฎหมาย ซึ่งองค์ความรู้ที่ได้จากงานวิจัยสามารถนำไปเป็นแนวทางเพิ่มศักยภาพการคุ้มครองผู้บริโภคในยุคดิจิทัลได้

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Sugar Composition Of Thai Desserts And Gut Microbiome Profiles In Healthy Volunteers: A Randomized Controlled Trial, Sayamon Senaprom Jan 2024

Sugar Composition Of Thai Desserts And Gut Microbiome Profiles In Healthy Volunteers: A Randomized Controlled Trial, Sayamon Senaprom

Chulalongkorn University Theses and Dissertations (Chula ETD)

The glycemic index (GI) measures the blood glucose-raising potential of carbohydrate-rich foods and is associated with obesity and insulin resistance. In addition, an imbalanced gut microbiota has been linked to elevated postprandial blood glucose levels. However, the relationship between consuming Thai desserts predominantly composed of carbohydrates and gut microbiome profiles remains unclear. This study aimed to evaluate the effects of consuming various Thai desserts with different GI values on the gut microbiomes of healthy volunteers. This open-label, parallel randomized clinical trial involved 30 healthy individuals aged 18 to 45 years. Participants were randomly assigned to one of three groups: Phetchaburi’s …

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A Comparative Study Of Portal Versus Peripheral Circulating Tumor Cells In Patients With Stage I-Iii Pancreatic Cancer, Thaninee Prasoppokakorn Jan 2024

A Comparative Study Of Portal Versus Peripheral Circulating Tumor Cells In Patients With Stage I-Iii Pancreatic Cancer, Thaninee Prasoppokakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Portal venous circulating tumor cells (CTCs) detection may better reflect vascular metastasis and predict micro-metastasis risk in pancreatic ductal adenocarcinoma (PDAC) than peripheral blood. We hypothesize that portal CTCs could better represent micro-metastasis and predict survival in PDAC patients. Methods: We conducted a single-center, prospective interventional cohort study of patients with stage I-III PDAC between January 2020 and September 2021, with followed up until February 2024. Portal venous blood was obtained via endoscopic ultrasound (EUS)-guided sampling, and peripheral blood was collected on the same day. CTCs were detected using EpCAM and mucin1 antibodies and reported as cells/8mL of blood. …

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Profiling The Microbiome In Breast Cancer Patients Before And After Treatment With Cannabis Oil, May Soe Thu Jan 2024

Profiling The Microbiome In Breast Cancer Patients Before And After Treatment With Cannabis Oil, May Soe Thu

Chulalongkorn University Theses and Dissertations (Chula ETD)

With long-term cancer treatment, female breast cancer patients encounter debilitating side effects from a current range of cancer therapies. Cannabinoids (CBs) have been widely used due to their efficacy on chemotherapy-associated pain. Although there is some evidence that cannabis oil may enhance quality of life and lessen symptoms in people with breast cancer, this is not very substantial. No randomised trials evaluating the effects of cannabis in breast cancer patients has been conducted before. The microbiome is critical to human health and disease, and accumulating data suggests that it is influenced by a variety of external variables, including marijuana, cannabis, …

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The Analysis Of Electric Vehicle's Adoption And Impact Of The Stimulation Policy In Thailand, Theeradol Techa-Erawan Jan 2024

The Analysis Of Electric Vehicle's Adoption And Impact Of The Stimulation Policy In Thailand, Theeradol Techa-Erawan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Thai government aims to reduce greenhouse gas (GHG) emissions in the transportation sector and establish Thailand as an electric vehicle (EV) hub in Southeast Asia by 2025. This study focuses on battery electric vehicles (BEVs) due to their potential for reducing emissions. Given the importance of the motor vehicles and parts are Thailand’s third most valuable export category, with exports accounting for 59.5% of the country’s GDP in 2019—the study analyzes consumer preferences for EV attributes and explores public attitudes toward EV stimulation policies. A Discrete Choice Experiment (DCE) survey is conducted with 363 participants in Bangkok, revealing that …

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Thailand As Gay-Friendly Destination In Indonesian Gay Men’S Perception, Sarah Geraldine Wullur Jan 2024

Thailand As Gay-Friendly Destination In Indonesian Gay Men’S Perception, Sarah Geraldine Wullur

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research explores the perception of Indonesian gay men toward Thailand as a gay-friendly destination. This study employs a qualitative approach, conducting in-depth interviews with 15 respondents aged 18 to 45 who identify as Indonesian gay individuals and have traveled to Thailand at least once, engaging in gay-related activities during their visit. The findings indicate that Indonesian gay men perceived Thailand favorably as a gay-friendly destination, due to its welcoming and progressive atmosphere. The society was viewed as accepting of gay culture, regardless of how individuals express themselves or their preferences. Moreover, the Y series emerged as the most significant …

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Influence Of Out-Of-Home Advertising Value On Consumer Attitude And Purchase Intention Of Samsung Smartphones, Napat Kusolrerkdee Jan 2024

Influence Of Out-Of-Home Advertising Value On Consumer Attitude And Purchase Intention Of Samsung Smartphones, Napat Kusolrerkdee

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research investigates the influence of out-of-home (OOH) advertising value on consumer attitudes and purchase intention towards Samsung smartphones. Data were collected via an online survey from 304 male and female respondents, aged 25 to 60 years, residing in Bangkok, who had encountered at least one of Samsung's OOH advertisements, including outdoor, transit, and in-store advertisements, in the past week. The study reveals that all five dimensions of advertising value (i.e. informativeness, credibility, entertainment, irritation, and overall advertising value) significantly influenced attitude towards the advertisement while the credibility dimension was the sole dimension of advertising value impacting attitude towards the …

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Thai Millennial Consumers’ Behavior Towards Nutrition And Health Claims On Food Packaging, Ruth Maura Prabaswara Wijayanti Jan 2024

Thai Millennial Consumers’ Behavior Towards Nutrition And Health Claims On Food Packaging, Ruth Maura Prabaswara Wijayanti

Chulalongkorn University Theses and Dissertations (Chula ETD)

This survey study examines the Thai millennial consumers' behavior towards nutrition and health claims (NHCs) on food packaging by studying the influences of consumers' perception on understanding, attitude, and purchase intention respectively. Data was collected through an online questionnaire from 272 Thai respondents, aged 28 to 43, and who had purchased food products with NHCs on the packaging. The findings reveal that among the influences between the four variables, consumer understanding has the highest degree of influence towards consumer attitude, followed by influences of consumer perception towards understanding, and consumer attitude towards purchase intention. The study concluded that consumer behavior …

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Generation Z'S Consumer Attitudes, Social Media Engagement, And Purchase Intentions In The Art Toys Blind Box Market, Supanut Anuwongpukdeechat Jan 2024

Generation Z'S Consumer Attitudes, Social Media Engagement, And Purchase Intentions In The Art Toys Blind Box Market, Supanut Anuwongpukdeechat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study explores Generation Z's consumer attitudes, social media engagement, and purchase intentions within the art toy blind box market, a niche yet rapidly growing industry driven by this demographic’s unique preferences. Using a quantitative approach, this research surveyed 205 Thai Generation Z respondents aged 18-27 to assess the relationship between their attitudes, levels of social media engagement, and purchase intentions related to art toy blind boxes. The findings reveal a strong positive correlation (r = 0.797) between social media engagement (M = 3.94) and purchase intentions (M = 4.07), highlighting the significant impact of online interactions on consumer behavior …

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The Impact Of Customer Engagement On User Retention In E-Commerce Apps In Vietnam, Vu Nguyen Tran Jan 2024

The Impact Of Customer Engagement On User Retention In E-Commerce Apps In Vietnam, Vu Nguyen Tran

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study examines how customer engagement impacts user retention in Vietnamese e-commerce apps, focusing on symbolic, hedonic, and utilitarian dimensions. A survey of 465 Vietnamese Millennials and Gen Z users (18–34) who used Shopee and/or Lazada in the past six months found symbolic engagement, aligning apps with users' values and identity, to be the strongest predictor of retention. Hedonic engagement showed a minor negative impact, while utilitarian engagement had no significant effect. The findings underscore the importance of symbolic engagement in offering actionable insights for branding and retention strategies in Vietnam’s e-commerce market.

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Effects Of Environmental Policy On Packaging Industry, Kittipong Nupak Jan 2024

Effects Of Environmental Policy On Packaging Industry, Kittipong Nupak

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study examines the impact of Thailand's 2020 single-use plastic bag ban on the packaging industry, focusing on the comparative analysis of plastic and paper firms. Utilizing a SWOT analysis framework, the study evaluates the strengths, weaknesses, opportunities, and threats posed by the policy implementation. Data spanning from 2018 to 2022 on return on assets (ROA) for both industries is analyzed to discern trends and correlations with the policy. Findings reveal significant reductions in plastic pollution and heightened public awareness as strengths of the policy. However, challenges such as incomplete enforcement and market shifts to paper alternatives emerge as weaknesses. …

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Effects Of The Japan – Thailand Economic Partnership Agreement (Jtepa) On Thailand’S Agricultural Trade With Japan, Kantawat Teeravithayapinyo Jan 2024

Effects Of The Japan – Thailand Economic Partnership Agreement (Jtepa) On Thailand’S Agricultural Trade With Japan, Kantawat Teeravithayapinyo

Chulalongkorn University Theses and Dissertations (Chula ETD)

This independent study investigates the impact of the Japan-Thailand Economic Partnership Agreement (JTEPA) on agricultural trade between Thailand and Japan. By employing the gravity model framework, the study analyzes the determinants of bilateral agricultural trade flows, focusing on key commodities such as meat, fish, seafood, edible preparations, and rice.The literature review highlights the significance of free trade agreements (FTAs) in facilitating trade and the potential benefits they offer to member countries. Studies on FTAs across various regions underscore the importance of reducing trade barriers and tariffs to promote agricultural trade flows.Utilizing panel data techniques, the empirical analysis examines the relationship …

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Circular Economy Strategies For Sustainable Growth And Development In The Paper And Packaging Industry, Suwimon Saret Jan 2024

Circular Economy Strategies For Sustainable Growth And Development In The Paper And Packaging Industry, Suwimon Saret

Chulalongkorn University Theses and Dissertations (Chula ETD)

The paper and packaging industry in Southeast Asia is experiencing rapid growth, driven by economic expansion and a growing demand for sustainable solutions. This research investigates the potential of circular economy practices within this industry, focusing on the Thai market. A case study of SCG Packaging demonstrates a positive correlation between circular practices and economic performance, with their revenue from circular packaging products (reusable, recyclable, and compostable) increasing from 16% to 57% of total revenue within five years. However, limitations exist. The economic impact analysis relies on data from a single company, and further research encompassing a broader industry scope …

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Market Entry Strategy For Black Garlic Supplements In Myanmar Through Partnership With Cmhl, Saw Yoon Yu Nan Jan 2024

Market Entry Strategy For Black Garlic Supplements In Myanmar Through Partnership With Cmhl, Saw Yoon Yu Nan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The COVID-19 pandemic has significantly increased the demand for supplements, vitamins, and minerals as people seek to boost their immune systems and overall wellness. Among these, black garlic has gained popularity for its unique flavor and perceived health benefits. This research explores the feasibility of entering the Myanmar market with black garlic supplements through a strategic partnership with City Mart Holdings Limited (CMHL), Myanmar's largest retail conglomerate.The study aims to assess market demand, regulatory requirements, and CMHL's distribution network to develop an effective market entry strategy. Key objectives include evaluating consumer interest, understanding regulatory hurdles, and leveraging CMHL's extensive distribution …

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The Impact Of Foreign Direct Investment On Employment In The Asean Region, Kaichen Tang Jan 2024

The Impact Of Foreign Direct Investment On Employment In The Asean Region, Kaichen Tang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigates the impact of foreign direct investment (FDI) inflows on employment levels in ASEAN countries from 1992 to 2022. Utilizing descriptive statistics, correlation matrices, and econometric models including the pooled ordinary least squares, fixed effects and random effects models, the findings indicate that FDI inflows generally have a positive and significant effect on employment. However, this impact varies across countries, with some experiencing positive effects while others face negative impacts. The study also controls for economic growth, inflation, trade openness, education levels, and political stability. The results highlight the necessity for policymakers to consider country-specific conditions when developing …

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Exploring Market Dynamic And Strategies For Food Supplement Industry In Thailand: A Case Study Of Black Garlic, Nan Su Wai Jan 2024

Exploring Market Dynamic And Strategies For Food Supplement Industry In Thailand: A Case Study Of Black Garlic, Nan Su Wai

Chulalongkorn University Theses and Dissertations (Chula ETD)

The food supplement industry in Thailand has been experiencing rapid growth due to increasing health consciousness, an aging population, rising disposable incomes, and urbanization. Within this industry, black garlic has become one of the significant products in Thailand due to its enhanced nutrient profile compared to fresh garlic. The paper aims to provide a comprehensive understanding of the current market landscape, consumer preferences and trends, and to recommend strategic approaches for the development of the black garlic sector. This paper focuses on analyzing the macro and micro-environmental factors affecting the food supplement industry, specifying the black garlic market in Thailand. …

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The Impact Of Inward Foreign Direct Investment (Fdi) On Total Factor Productivity Growth (Tfpg) In Asian Countries, Jiao Lu Jan 2024

The Impact Of Inward Foreign Direct Investment (Fdi) On Total Factor Productivity Growth (Tfpg) In Asian Countries, Jiao Lu

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study examines the impact of inward foreign direct investment (FDI) on total factor productivity (TFP) growth in 23 Asian countries from 1991 to 2018. Using a dynamic panel data model, this study analyzes how FDI, together with GDP growth, capital and labor inputs, human capital, export growth, internet usage, and distance to the technology frontier, affects total factor productivity (TFP) growth. The results indicate that, while FDI remains significant, its impact on total factor productivity (TFP) growth is negative.The negative impact may be caused by the lack of sufficient human capital and absorptive capacity in host countries, along with …

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Optimal Dual-Time-Point Dynamic 68ga-Psma-11 Pet/Ct Protocols For Parametric Imaging Generation In Prostate Cancer Patients, Paphawarin Burasothikul Jan 2024

Optimal Dual-Time-Point Dynamic 68ga-Psma-11 Pet/Ct Protocols For Parametric Imaging Generation In Prostate Cancer Patients, Paphawarin Burasothikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Globally, prostate cancer is the second most common cancer for men. Prostate cancer patients presenting metastasis exhibit a poor prognosis, consequently leading to diminished survival rates. Thus, 68Ga-PSMA-11 PET/CT examination plays a critical role in prostate cancer diagnosis. Parametric imaging techniques offer the potential to improve the accuracy of quantification analysis in PET/CT diagnosis, but their effectiveness is constrained by lengthy acquisition protocols. This study developed optimal dual-time-point (DTP) parametric imaging using shortened dynamic 68Ga-PSMA-11 PET/CT scans in prostate cancer patients and investigated the feasibility of parametric images in terms of image quality by comparing them with a routine standardized …

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การสร้างแอนิเมชัน 3 มิติ ของใบหน้าขณะพูดภาษาไทยสําหรับใช้ในการพัฒนาเกม, ภัทรานิษฐ์ มุสิกะประยูร Jan 2024

การสร้างแอนิเมชัน 3 มิติ ของใบหน้าขณะพูดภาษาไทยสําหรับใช้ในการพัฒนาเกม, ภัทรานิษฐ์ มุสิกะประยูร

Chulalongkorn University Theses and Dissertations (Chula ETD)

โครงงานมหาบัณฑิตนี้จึงเสนอวิธีการสร้างแอนิเมชัน 3 มิติ ของใบหน้าขณะพูดภาษาไทยสำหรับใช้ในการพัฒนาเกม ในการสร้างแบบจำลองเพื่อทำนายการเคลื่อนไหวของใบหน้าขณะพูดภาษาไทย ได้ใช้ชุดข้อมูลออดิโอวิชวล TSynC-3miti: Audiovisual Speech Synthesis Database from Found Data ร่วมกับแนวคิดจาก งานวิจัย A Decision Tree Framework for Spatiotemporal Sequence Prediction ที่ได้เสนอวิธีการสำหรับการทำนายลำดับข้อมูลที่มีจำนวนมิติสูงและต่อเนื่อง โดยใช้เทคนิคการแบ่งย่อยด้วยหน้าต่างเลื่อนร่วมกับวิธีการรวมกลุ่มของต้นไม้ตัดสินใจ ซึ่งสามารถนำมาประยุกต์ใช้ในการสร้างแอนิเมชันสำหรับการพูดได้ ในการทำนายการเคลื่อนไหวของใบหน้าขณะพูดภาษาไทยในโครงงานมหาบัณฑิตนี้ จะใช้ข้อมูลนำเข้าเป็นลำดับของสัญลักษณ์โฟเนติก จากจึงต้องมีการเตรียมชุดข้อมูลใหม่จากชุดข้อมูลออิดิโอวิชวล TSynC-3miti จากนั้นนำชุดข้อมูลไปฝึกสอนโมเดล และพัฒนาเครื่องมือที่ใช้ในการสร้างแอนิเมชัน โดยเป็นรูปแบบของส่วนเสริมสำหรับใช้ในเกมเอนจิน Unreal Engine โดยรับอินพุตเป็นข้อความภาษาไทย และจะได้ค่าการเคลื่อนไหวใบหน้ามาอ้างอิงบนใบหน้าของตัวละครในแต่ละช่วงเวลา ผลลัพธ์ของการทำงานของส่วนเสริมนี้จะได้เป็นแอนิเมชัน 3 มิติของโมเดลตัวละคร MetaHuman ที่สามารถพูดภาษาไทยได้อย่างสมจริง โดยผลการทดสอบพบว่าแอนิเมชันมีความสมจริงจากมุมมองทั้งหน้าตรงและหน้าเอียง โดยมุมมองหน้าเอียงดูสมจริงมากกว่า และการออกเสียงแต่ละโฟเนติกมีความสมจริงเช่นกัน

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Green Urbanisam And Human Well-Being In Developing Countries, Phenphit Boonhor Jan 2024

Green Urbanisam And Human Well-Being In Developing Countries, Phenphit Boonhor

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigates the relationship between green urbanism and human well-being in developing countries, focusing on the influence of individual and cultural values on the utilization of urban green spaces (UGS). As rapid urbanization transforms cities, there is a pressing need to address the environmental and health challenges that arise, particularly in regions with limited infrastructure and resources. The research highlights significant disparities between developed and developing nations regarding sustainability efforts, with developing countries facing increasing urban population growth alongside declining environmental conditions. Through a comprehensive literature review and empirical analysis, this study aims to elucidate how cultural perspectives on …

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Exploring Sustainable Initiatives, Innovations, And Challenges In Sports Sustainability : A Case Study Of The Olympic Games, Suwanna Silpaarcha Jan 2024

Exploring Sustainable Initiatives, Innovations, And Challenges In Sports Sustainability : A Case Study Of The Olympic Games, Suwanna Silpaarcha

Chulalongkorn University Theses and Dissertations (Chula ETD)

The progress of sustainability in sports mega-events have been more prominent than ever due to its substantial impact on society, the economy, and the environment. The Olympic Games’ immense magnitude has sparked apprehensions regarding their ecological and societal ramifications—increased energy usage and waste, transportation demands, new infrastructural constructions—which all have significant impacts on the environment and carbon emissions. Because of this, the IOC, host cities, and related sports authorities are constantly evolving and seeking innovative solutions towards sustainability while overcoming challenges faced. Given the importance of sustainable development in sports, this study examines sustainable approaches and solutions adopted by the …

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The Association Of Mirnas As Biomarkers For Severe Liver Dysfunction In Severe Dengue Infection, Napat Pas-Arj Jan 2024

The Association Of Mirnas As Biomarkers For Severe Liver Dysfunction In Severe Dengue Infection, Napat Pas-Arj

Chulalongkorn University Theses and Dissertations (Chula ETD)

Identification early biomarkers for severe liver dysfunction in severe dengue patients is essential. Currently, there is no any data on circulating miRNAs to predict this important complication, Therefore, this study aimed to explore the role of circulating miRNAs in severe liver dysfunction in dengue infection. On the initial day of admission, serum samples were gathered from patients with dengue infection. These patients were monitored for 14 days post-admission to ascertain their final diagnosis. Following the WHO 2009 criteria, participants were categorized into severe liver dysfunction and non-severe liver dysfunction group. To conduct a transcriptomic analysis of circulating miRNAs used the …

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Gene Expression By Nanostring Rna Profiling Of Monocytic Myeloid-Derived Suppressor Cells In Knee Osteoarthritis, Varote Shotelersuk Jan 2024

Gene Expression By Nanostring Rna Profiling Of Monocytic Myeloid-Derived Suppressor Cells In Knee Osteoarthritis, Varote Shotelersuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Osteoarthritis (OA) is a widespread degenerative joint disease marked by cartilage destruction. This study investigates the role of monocytic myeloid-derived suppressor cells (M-MDSCs) in OA, focusing on their gene expression profiles and their relationship with body mass index (BMI) in knee OA patients. Previous research has shown a positive correlation between M-MDSCs and BMI in OA. We explored the role of M-MDSCs derived from the infrapatellar fat pad (IPFP) in OA patients.Using NanoString technology, we examined the transcriptional profile of M-MDSCs from the IPFP of knee OA patients undergoing total knee replacement surgery, categorized into different BMI groups. Flow cytometry …

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Association Between Volunteering, Wellbeing, And Homo-Negativity: An Analysis Of World Values Survey, Amirhossein Khanehpaza Jan 2024

Association Between Volunteering, Wellbeing, And Homo-Negativity: An Analysis Of World Values Survey, Amirhossein Khanehpaza

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: Homonegativity adversely affects the health and well-being of homosexuals in society, making it vital to identify factors associated with it. This study investigates whether active membership in voluntary organizations correlates with homonegativity, examining how this varies by gender and age.Methods: Using the World Values Survey data (2017-2022) from 87,777 participants in 63 countries, we performed binary logistic regression to assess relationships between homonegativity and factors including socioeconomic status, demographics, and voluntary activity participation.Results: Our findings suggest that active membership in certain voluntary organizations correlates with homonegativity levels among both men and women across various age groups. Specifically, active participation …

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Zero-Shot Adaptation Of Molecular Generative Adversarial Network For Specific Protein Targets, Ravipas Aphikulvanich Jan 2024

Zero-Shot Adaptation Of Molecular Generative Adversarial Network For Specific Protein Targets, Ravipas Aphikulvanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

Drug discovery, crucial for identifying new potential drug candidates to treat diseases and improve health, is increasingly enhanced by deep learning approaches such as molecular generation models. However, creating drug candidates with desired properties, such as the quantitative estimate of drug-likeness (QED), synthetic accessibility (SA), and binding affinity (BA), remains a significant challenge, especially when training generative models for specific protein targets with limited pharmaceutical data. Addressing these challenges, this thesis presents Mol-Zero-GAN, a novel framework designed to generate drug candidates tailored to specific protein targets without additional data by employing zero-shot adaptation techniques and Bayesian optimization (BO). By fine-tuning …

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Machine Learning Model For Skill Level Prediction Inmultiplayer Online Battle Arena, Vachirawit Pepatang Jan 2024

Machine Learning Model For Skill Level Prediction Inmultiplayer Online Battle Arena, Vachirawit Pepatang

Chulalongkorn University Theses and Dissertations (Chula ETD)

The ranked matchmaking system in MOBA games like DotA 2 matches players with similar skill levels, enhancing enjoyment, fairness, and competitiveness. However, current MOBA ranking systems calculate a player's ranking based on match outcomes rather than the player's individual performance, resulting in unfairness for players who perform better or worse than the rest of the team. Therefore, it is necessary to use multiple match data to correctly rate players' skills. Additionally, boosting leads to players using accounts that do not match their actual skill level. This causes negative experiences for other players and ultimately makes the game less enjoyable. This …

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Multiple Face Detection And Recognition For System-On-Chip Fpgas, Siraphop Santiwiwat Jan 2024

Multiple Face Detection And Recognition For System-On-Chip Fpgas, Siraphop Santiwiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recognizing multiple faces within a single frame or image presents a significant challenge in facial recognition tasks. This challenge demands robust algorithms capable of handling variations in facial position, unstable brightness, and the presence of accessories such as glasses or hats. However, in current surveillance applications, multiple face recognition is vital for maintaining various security measures. In such applications, there is a need for processors that are compact and deployable in diverse environments. FPGA is popular due to its compact size, cost-effectiveness, and high performance. In this thesis, we proposed the implementation of multiple face detection and recognition on an …

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Mixed-Reality Learning Environment In Studio-Based Learning To Enhance Creative Problem-Solving For Architecture, Thadharphut Limapornvanitr Jan 2024

Mixed-Reality Learning Environment In Studio-Based Learning To Enhance Creative Problem-Solving For Architecture, Thadharphut Limapornvanitr

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research and development aim to 1) address the factor structure of creative problem-solving skills for undergraduate architecture students in Thailand. 2) identify what technology-fostered, mixed-reality learning environment for studio-based design learning could enhance the creative problem-solving of undergraduate architecture students in Thailand. 3) design and develop a mixed-reality learning environment in studio-based learning to enhance creative problem-solving for architecture. 4) define mixed-reality learning environments in studio-based learning to enhance creative problem-solving for architecture. Samples are a multistage random sampling of 655 undergraduate architecture students in Thailand. Three experts in the first phase validated the self-evaluation form. Nineteen undergraduate students …

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Magnetic Particles With Molecularly Imprinted Polymer For Aflatoxin Adsorption In Food, Wanrasa Bilhod Jan 2024

Magnetic Particles With Molecularly Imprinted Polymer For Aflatoxin Adsorption In Food, Wanrasa Bilhod

Chulalongkorn University Theses and Dissertations (Chula ETD)

Aflatoxins (AF) are harmful carcinogens found in feeds and foods. Aflatoxin B1, the most known natural carcinogen, was classified as a Group I carcinogen by the International Agency for Research on Cancer (IARC). To respond to this problem, molecularly imprinted polymers coated on Fe3O4 nanoparticles (Fe3O4@MIP) were synthesized by polymerization method using 5,7-dimethoxycoumarin (DMC) as the template and methacrylic acid (MAA) as the functional monomer. Fe3O4 magnetic nanoparticles were used as a core structure to enhance recycling performance. After the removal of the template, Fe3O4@MIP composites were characterized using x-ray powder diffraction spectroscopy (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating …

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System Of Stochastic Grey Differential Equations With Singular Spectrum Analysis For Precious Metal Prices Forecasting, Rammarat Panadsako Jan 2024

System Of Stochastic Grey Differential Equations With Singular Spectrum Analysis For Precious Metal Prices Forecasting, Rammarat Panadsako

Chulalongkorn University Theses and Dissertations (Chula ETD)

โลหะมีค่าเป็นกลุ่มโลหะที่มีมูลค่าทางเศรษฐกิจสูงกว่าโลหะทั่วไป ดังนั้นการพยากรณ์ราคาของโลหะมีค่าจึงเป็นหนึ่งปัญหาที่น่าสนใจ ซึ่งการพยากรณ์ราคาของโลหะมีค่ามีหลากหลายวิธี โดยวิทยานิพนธ์ฉบับนี้มีจุดประสงค์เพื่อพัฒนาระบบสมการเชิงอนุพันธ์เกรย์สโตแคสติกกับการวิเคราะห์สเปกตรัมเอกฐาน (SGDE+SSA) ในการพยากรณ์ราคาของทองคำ เงิน แพลทินัม และแพลเลเดียม ในขั้นตอนแรกจะทำการสร้างแบบจำลอง SGDE+SSA แบบหนึ่งมิติ เพื่อพยากรณ์ราคาของโลหะมีค่าทั้งสี่ชนิดโดยไม่พิจารณาค่าสหสัมพันธ์ของโลหะเหล่านี้ แต่ในความเป็นจริงราคาของโลหะเหล่านี้มีความสัมพันธ์กัน ดังนั้นแบบจำลอง SGDE+SSA แบบหลายมิติจึงถูกสร้างขึ้น โดยมีการพิจารณาค่าสหสัมพันธ์ที่เกิดจากการวิเคราะห์ข้อมูลราคาในอดีตเพื่อให้แบบจำลองมีความเหมาะสมกับสถานการณ์จริงมากยิ่งขึ้น สำหรับการวิเคราะห์ความอ่อนไหวจะศึกษาโดยการพัฒนาวิธีการคัดเลือกค่าพารามิเตอร์เพื่อเพิ่มประสิทธิภาพของแบบจำลอง นอกจากนี้ค่าคาดหวังและค่าความแปรปรวนของผลเฉลยทางตัวเลขถูกแสดงโดยคำนวณจากแบบจำลอง ความแม่นยำของแบบจำลอง SGDE+SSA แบบหนึ่งมิติ และแบบจำลอง SGDE+SSA แบบหลายมิติ จะถูกแสดงผ่านค่า MAPE ซึ่งเป็นการเปรียบเทียบระหว่างราคาจากแบบจำลองและราคาของโลหะมีค่าในอดีตตั้งแต่เดือนมกราคม พ.ศ. 2548 ถึง เดือนมกราคม พ.ศ. 2567 ผลการศึกษาครั้งนี้พบว่าแบบจำลอง SGDE+SSA แบบหนึ่งมิติสำหรับราคาการพยากรณ์ในช่วงชุดการเรียนรู้ และสำหรับสำหรับราคาที่พยากรณ์ในช่วงข้อมูลชุดทดสอบ แบบจำลอง SGDE+SSA แบบหนึ่งมิติมีความเชี่ยวชาญในการคาดการณ์ราคาของเงิน ในขณะที่แบบจำลอง SGDE+SSA แบบหลายมิติมีประสิทธิภาพในการทำนายราคาของทองคำและแพลทินัม โดยรวมแล้วแบบจำลองเหล่านี้มีประสิทธิภาพในการทำนายราคาทองคำ เงินและแพลทินัม

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