Digital Commons Network^™

Increasing Social Determinants Of Health Screening Rates Among Six Endocrinology Centers Across The United States: Results From The T1d Exchange Quality Improvement Collaborative, Ori Odugbesan, Trevon Wright, Nana-Hawa Yayah Jones, Selorm Dei-Tutu, Mary Pat Gallagher, Emily Dewit, Roberto E Izquierdo, Marisa Desimone, Nicole Rioles, Osagie Ebekozien

Faculty, Staff and Students Publications

Social determinants of health (SDOH) are strongly associated with outcomes for people with type 1 diabetes. Six centers in the T1D Exchange Quality Improvement Collaborative applied quality improvement principles to design iterative Plan-Do-Study-Act cycles to develop and expand interventions to improve SDOH screening rates. The interventions tested include staff training, a social risk index, an electronic health record patient-facing portal, partnerships with community organizations, and referrals to community resources. All centers were successful in improving SDOH screening rates, with individual site improvements ranging from 41 to 70% and overall screening across the six centers increasing from a baseline of 1% …

Multimodal Prediction Of Obsessive-Compulsive Disorder And Comorbid Depression Severity And Energy Delivered By Deep Brain Electrodes, Saurabh Hinduja, Ali Darzi, Itir Onal Ertugrul, Nicole Provenza, Ron Gadot, Eric A Storch, Sameer A Sheth, Wayne K Goodman, Jeffrey F Cohn

Faculty, Staff and Students Publications

To develop reliable, valid, and efficient measures of obsessive-compulsive disorder (OCD) severity, comorbid depression severity, and total electrical energy delivered (TEED) by deep brain stimulation (DBS), we trained and compared random forests regression models in a clinical trial of participants receiving DBS for refractory OCD. Six participants were recorded during open-ended interviews at pre- and post-surgery baselines and then at 3-month intervals following DBS activation. Ground-truth severity was assessed by clinical interview and self-report. Visual and auditory modalities included facial action units, head and facial landmarks, speech behavior and content, and voice acoustics. Mixed-effects random forest regression with Shapley feature …

Human Plcg2 Haploinsufficiency Results In A Novel Natural Killer Cell Immunodeficiency, Joshua B Alinger, Emily M Mace, Justin R Porter, Annelise Y Mah-Som, Allyssa L Daugherty, Stephanie Li, Allison A Throm, Jeanette T Pingel, Nermina Saucier, Albert Yao, Ivan K Chinn, James R Lupski, Mohammad Ehlayel, Michael Keller, Greg R Bowman, Megan A Cooper, Jordan S Orange, Anthony R French

Faculty, Staff and Students Publications

Background:

Although most individuals effectively control herpesvirus infections, some suffer from severe and/or recurrent infections. A subset of these patients possess defects in NK cells, lymphocytes which recognize and lyse herpesvirus-infected cells; however, the genetic etiology is rarely diagnosed. PLCG2 encodes a signaling protein in NK cell and B cell signaling. Dominant-negative or gain-of-function variants in PLCG2 cause cold urticaria, antibody deficiency, and autoinflammation. However, loss-of-function variants and haploinsufficiency have not been reported to date.

Objective:

We aimed to identify the genetic cause of NK cell immunodeficiency in two families, and herein describe the functional consequences of two novel loss-of-function …

Case Report: P40phox Deficiency Underlying Pediatric-Onset Systemic Lupus Erythematosus, Alejandro Nieto-Patlán, Natalia S Fernández Dávila, Yuqing Wang, Michelle Zelnick, Eyal Muscal, Martha Curry, James R Lupski, Steven M Holland, Bo Yuan, Douglas B Kuhns, Tiphanie P Vogel, Ivan K Chinn

Faculty, Staff and Students Publications

Introduction

Systemic lupus erythematosus is a multi-faceted autoimmune disorder of complex etiology. Pre-pubertal onset of pediatric systemic lupus erythematosus (pSLE) is uncommon and should raise suspicion for a genetic driver of disease. Autosomal recessive p40^phox deficiency is a rare immunologic disorder characterized by defective but not abolished NADPH oxidase activity with residual production of reactive oxygen species (ROS) by phagocytic cells.

Case presentation

We report the case of a now 18-year-old female with pSLE onset at 7 years of age. She presented with recurrent fever and malar rash. Aspects of her immune dysregulation over time have included typical pSLE …

The Legal Metaverse And Comparative Taxonomy: A Reappraisal, Ugo Mattei

Faculty Scholarship

The present Article revisits my “Three Patterns of Law: Taxonomy and Change in the World’s Legal Systems”—published in this very Journal a quarter century ago—which acknowledged the ideological nature of the law versus politics distinction and posited taxonomy as a means for understanding law. The original article classified law into professional law, political law, and traditional law, and heralded the tentative and dynamic natures of such classification. The two purposes of the present Article are to (i) reflect on legal transformations that have since occurred as reactions to global geopolitical, technological, and economic changes, and (ii) interrogate whether epistemological assumptions …

Idppub: Illuminating The Dark Phosphoproteome Through Pubmed Mining, Sara R Savage, Yaoyun Zhang, Eric J Jaehnig, Yuxing Liao, Zhiao Shi, Huy Anh Pham, Hua Xu, Bing Zhang

Faculty, Staff and Students Publications

Global phosphoproteomics experiments quantify tens of thousands of phosphorylation sites. However, data interpretation is hampered by our limited knowledge on functions, biological contexts, or precipitating enzymes of the phosphosites. This study establishes a repository of phosphosites with associated evidence in biomedical abstracts, using deep learning-based natural language processing techniques. Our model for illuminating the dark phosphoproteome through PubMed mining (IDPpub) was generated by fine-tuning BioBERT, a deep learning tool for biomedical text mining. Trained using sentences containing protein substrates and phosphorylation site positions from 3000 abstracts, the IDPpub model was then used to extract phosphorylation sites from all MEDLINE abstracts. …

A Comprehensive Analysis Of Neuroblastoma Incidence, Survival, And Racial And Ethnic Disparities From 2001 To 2019, Kevin Campbell, David A Siegel, Puja J Umaretiya, Shifan Dai, Andras Heczey, Philip J Lupo, Jeremy M Schraw, Trevor D Thompson, Michael E Scheurer, Jennifer H Foster

Faculty, Staff and Students Publications

BACKGROUND: We characterize the incidence and 5-year survival of children and adolescents with neuroblastoma stratified by demographic and clinical factors based on the comprehensive data from United States Cancer Statistics (USCS) and the National Program of Cancer Registries (NPCR).

METHODS: We analyzed the incidence of neuroblastoma from USCS (2003-2019) and survival data from NPCR (2001-2018) for patients less than 20 years old. Incidence trends were calculated by average annual percent change (AAPC) using joinpoint regression. Differences in relative survival were estimated comparing non-overlapping confidence intervals (CI).

RESULTS: We identified 11,543 primary neuroblastoma cases in USCS. Age-adjusted incidence was 8.3 per …

Validation Of A New Patient-Reported Outcome Measure Of The Functional Impact Of Essential Tremor On Activities Of Daily Living, Ludy C Shih, Michael T Stevenson, Steven Bellows, Alfonso Fasano, Sheng-Han Kuo, Kelly E Lyons, Henry Moore, Holly A Shill, Aparna Wagle Shukla, Carlos Singer, Rodger J Elble

Faculty, Staff and Students Publications

BACKGROUND: The Essential Tremor Rating Assessment Scale (TETRAS) is a popular scale for essential tremor (ET), but its activities of daily living (ADL) and performance (P) subscales are based on a structured interview and physical exam. No patient-reported outcome (PRO) scale for ET has been developed according to US regulatory guidelines.

OBJECTIVE: Develop and validate a TETRAS PRO subscale.

METHODS: Fourteen items, rated 0-4, were derived from TETRAS ADL and structured cognitive interviews of 18 ET patients. Convergent validity analyses of TETRAS PRO versus TETRAS ADL, TETRAS-P, and the Quality of Life in Essential Tremor Questionnaire (QUEST) were computed for …

Cisplatin Vestibulotoxicity: A Current Review, Tamara Fleihan, Marc Elie Nader, J David Dickman

Faculty, Staff and Students Publications

Cisplatin, a commonly used chemotherapy drug, is well-established for its ototoxic effects, primarily attributed to the damage it inflicts on cochlear hair cells. However, its impact on the vestibular system remains inadequately understood. Here, we provide a comprehensive review of existing literature concerning cisplatin-induced vestibulotoxicity. Animal studies have shown that cisplatin induces a vestibular hair cell loss that is dose-dependent, with the severity of damage also varying according to the route of administration. Notably, intratympanic and systemic injections in animal models have manifested significant damage primarily to utricular hair cells, with a lesser degree of damage observed for the other …

Blind To The Perils Of Pursuing Food: Behaviors Of Individuals With Smith-Magenis Syndrome, Citrine Elatrash, Jenna Shi, Theresa Wilson, Sarah H Elsea, Stephanie Sisley

Faculty, Staff and Students Publications

PURPOSE: Discrepancies exist between the need to lock food away and satiety scores in the Smith-Magenis syndrome (SMS) population. This study sought to uncover food-related behaviors within this unique group of individuals.

METHODS: Caregivers (

RESULTS: This study identified a global theme of "Blind to the perils while pursuing their goals," supported by 5 organizing themes: (1) Biology-impacting behaviors, (2) Need for personalized strategies, (3) Controlling food experiences, (4) Need for parents to orchestrate life, and (5) Surprising resourcefulness. Subthemes within these organizing themes highlighted that individuals with SMS have unique food-related behaviors and often fixate on certain types of …

Succinic Semialdehyde Dehydrogenase Deficiency: A Metabolic And Genomic Approach To Diagnosis, Kevin E Glinton, Charul Gijavanekar, Abbhirami Rajagopal, Laura P Mackay, Kirt A Martin, Phillip L Pearl, K Michael Gibson, Theresa A Wilson, V Reid Sutton, Sarah H Elsea

Faculty, Staff and Students Publications

Genomic sequencing offers an untargeted, data-driven approach to genetic diagnosis; however, variants of uncertain significance often hinder the diagnostic process. The discovery of rare genomic variants without previously known functional evidence of pathogenicity often results in variants being overlooked as potentially causative, particularly in individuals with undifferentiated phenotypes. Consequently, many neurometabolic conditions, including those in the GABA (gamma-aminobutyric acid) catabolism pathway, are underdiagnosed. Succinic semialdehyde dehydrogenase deficiency (SSADHD, OMIM #271980) is a neurometabolic disorder in the GABA catabolism pathway. The disorder is due to bi-allelic pathogenic variants in

Tracking Updates In Clinical Databases Increases Efficiency For Variant Reanalysis, Lele Li, Xia Tian, Vaughan Woodzell, Richard A Gibbs, Bo Yuan, Eric Venner

Faculty, Staff and Students Publications

PURPOSE: Variant interpretation, guided by American College of Medical Genetics and Genomics guidelines, can inform clinical decision-making. However, interpretations may change over time for a variety of reasons. Periodic reanalysis of previous variant interpretations is important to ensure that reported genetic findings remain accurate according to current knowledge.

METHODS: We performed automated filtering by comparing ClinVar variants available in August 2020 with those from August 2021 to screen for potential reanalysis candidates from 3 projects. These variants were subsequently interpreted based on the American College of Medical Genetics and Genomics/Association for Molecular Pathology variant interpretation guideline or ClinGen revised gene-specific …

Comparative Exploration Of Mammalian Deafness Gene Homologues In The Drosophila Auditory Organ Shows Genetic Correlation Between Insect And Vertebrate Hearing, Daniel C Sutton, Jonathan C Andrews, Dylan M Dolezal, Ye Jin Park, Hongjie Li, Daniel F Eberl, Shinya Yamamoto, Andrew K Groves

Faculty, Staff and Students Publications

Johnston's organ, the Drosophila auditory organ, is anatomically very different from the mammalian organ of Corti. However, recent evidence indicates significant cellular and molecular similarities exist between vertebrate and invertebrate hearing, suggesting that Drosophila may be a useful platform to determine the function of the many mammalian deafness genes whose underlying biological mechanisms are poorly characterized. Our goal was a comprehensive screen of all known orthologues of mammalian deafness genes in the fruit fly to better understand conservation of hearing mechanisms between the insect and the fly and ultimately gain insight into human hereditary deafness. We used bioinformatic comparisons to …

Perceptions Of Benefits From Middle School Agricultural Education Programs, Michael Hunter

Murray State Theses and Dissertations

As agriculture education continues to evolve across the state of Georgia and the country, leaders need to understand the dynamic vision and the importance of this industry. Utilizing P-20 education initiatives and new concepts, leaders can implement agriculture education in more schools to increase diversity and provide students with opportunities to participate in the three-component model of agriculture education. This research aimed to explore the perceived benefits that high school principals, CTAE directors, and agriculture teachers have on middle school agriculture education programs. This research was confined to the Georgia FFA North Region. Findings indicated no significant evidence that middle …

Comparison Of Lidocaine Viscous Gargle And Topical Application On Laryngeal Mask Airway In General Anesthesia: A Randomized Clinical Trial, Yan Peng, Ju Qian, Yiqun Mao

Saudi Medical Journal

Objectives: To investigate the effects and safety of lidocaine viscous gargle on postoperative sore throat (POST) in patients receiving a laryngeal mask airway (LMA) in general anesthesia. Methods: In this randomized controlled trial, 90 patients undergoing urological surgery were allocated into 2 treatment arms (n=45): lidocaine viscous gargle before LMA insertion (Group G) and topical application of lidocaine viscous on the LMA (Group T). Outcome data were collected before placement of LMA (T0), after insertion of LMA (T1), immediately (T2), one hour (T3), and 24 hours after removal of LMA (T4). We analyzed the incidence of POST, pharynx dryness, and …

Cross-Cultural Modification Of The University Of Pennsylvania Smell Identification Test For The Saudi Arabian Population: Validation And Normative Values, Saad Alsaleh, Ahmed Alhussien, Nawaf Alsubaie, Ziyad Alajlan, Sakhar Albader, Ibrahim Alarifi, Hussain Albaharna, Ibrahim Sumaily

Saudi Medical Journal

Objectives: To develop a reliable version of the Saudi Arabian-University of Pennsylvania smell identification test (SA-UPSIT) and to establish normative values for both genders. Methods: This cross-sectional study was carried out on voluntarily recruited normal participants in King Saud University Medical City, Riyadh, Saudi Arabia, from April 2018 to May 2023. Culture-familiar odors were chosen and the kit was translated into Arabic for the study. The test was modified 3 times in 4 versions. Following this, a random sample was collected to carry out a re-test after 6 weeks. Results: A total of 288 subjects participated in the development of …

The Effect Of Having A Physician In The Triage Area On The Rate Of Patients Leaving Without Being Seen: A Quality Improvement Initiative At King Fahad Specialist Hospital, Faisal T. Mahmood, Mohammed M. Alghamdi, Mohammad O. Alqithmi, Nasser M. Faris, Muhammad U. Nasir, Ali Salman

Saudi Medical Journal

Objectives: To evaluate the effect of the presence of a physician in the triage area on the number of patients who leave without being seen (LWBS) and some of the factors affecting emergency department (ED) crowding. Methods: This was a pre-post study carried out at King Fahad Specialist Hospital, Dammam, Saudi Arabia. The 3-month study, consisting of 7826 patients, was split into pre-physician and post-physician periods. Variables compared across these periods were the number of LWBS patients, length of hospital stay, time to physician, and time to disposition decision. Statistical analysis was carried out using R version 4.3.0. Results: Our …

How Do Contraception Preferences Change Over Time? Eight Years Of Experience In A Tertiary Hospital, Merve A. Talmac, Seyma C. Yuksek, Selim Afsar, Aysegul Bestel, Izel Gunay, Ismail Ozdemir

Saudi Medical Journal

Objectives: To examine the contraceptive preferences of women based on their age and to track changes in these preferences over time. Methods: This was an observational, retrospective cross-sectional study. Data from 2742 patients were evaluated for this study. The patient group of the first 4 years was classified as Group I (n=1371) and the last 4 years was classified as Group II (n=1371). The preferred contraception methods between the groups and their changes across the years were examined. Results: Coitus interruptus was found to be the prevailing contraceptive method across all age groups, with 304 (70.9%) in 18-24 age group; …

Epidemiology Of Tuberculosis In Saudi Arabia Following The Implementation Of End Tuberculosis Strategy: Analysis Of The Surveillance Data 2015-2019, Maha M. Alawi, Haleema A. Alserehi, Ahmed O. Ali, Abeer M. Albalawi, Mashael K. Alanizi, Fatima M. Nabet, Modhi A. Alkamaly, Abdullah M. Assiri, Hani Jokhdar, Mohammed O. Qutub, Moahmmed A. Khoja, Esam I. Azhar, Wael A. Taskandi, Annes A. Sindi, Muhammad Yasir

Saudi Medical Journal

Objectives: To analyze the evolution of tuberculosis (TB) epidemiology in Saudi Arabia in the 5 years following the implementation of the end-TB Strategy. Methods: A retrospective analysis of surveillance data, reported by the national tuberculosis control program from 2015-2019, was carried out. The annual incidence and the percentage of yearly changes were calculated and compared to the World Health Organization (WHO) milestones, which anticipate a 4-5% annual decline. Additionally, various other epidemiological indicators of TB were examined. Results: The national TB incidence declined from 10.55% per 100,000 in 2015 to 8.76% per 100,000 in 2019, aligning with the WHO’s 2019 …

Developing, Translating, And Validating A Survey Instrument For Assessing Hospital Food Service Staff’S Food Safety Knowledge, Perceptions, And Practices During The Covid-19 Pandemic, Nisreen M. Abdulsalam, Hajar B. Alnomani

Saudi Medical Journal

Objectives: To develop and validate a questionnaire to assess the food safety knowledge, perceptions, and practices (KPPs) of hospital food service staff (FSS) amidst the challenges of the coronavirus disease-2019 (COVID-19) pandemic. Methods: The questionnaire was subjected to a rigorous evaluation process, which included a literature review and focus groups comprising the general public, FSS, and key experts in food service. The pilot testing highlighted its utility and determined its content validity ratio (CVR). Results: Most items received high CVR scores of 0.96, indicating excellent content validity. A subsequent pilot study involved 40 FSS. Reliability testing, using Cronbach’s alpha value …

Bolt Family Papers - Accession 476, Bolt Family

Manuscript Collection

The Bolt Family Papers consist mostly with family records related to the deaths of family members. It contains several handwritten funeral announcements, several obituaries and one piece of formal correspondence dealing with the death of A.W. Green. This collection also contains two bound volumes: a Methodist Hymnal, and a family Bible with genealogical entries documenting the births, deaths, and marriages of family members. A small collection of photographs is also included. For a list of family names consult Appendix I.

Ruth Williams Cupp Papers - Accession 467, Ruth Williams Cupp

Manuscript Collection

Ruth Williams Cupp (1928-2016) was a Charleston attorney, writer, historian and graduate of Winthrop College (Class of 1950) and USC Law School (Class of 1954). Ruth practiced law in the Charleston area until she became the first woman to be elected to the South Carolina House of Representatives (1962-1964). She lost her bid for reelection in 1964, partially due to her support for Lyndon B. Johnson and his reelection efforts. The Collection consists mostly from newspaper clippings ranging from 1961 to 1965 and mostly refers to her political, professional, community and personal life. Also included are several photographs related to …

Greenville Women's History Week Records - Accession 592, Women's History Week, Greenville

Manuscript Collection

The Greenville Women’s History Week Records consist of correspondence, advertisements, program evaluations, introductions, magazine articles, newspaper clippings, minutes, agenda, pamphlets, notes, addresses, photographs, proclamations, radio spots, receipts, resume, and exhibits. The Women’s History Week was created to honor the roles women have played in the history of the United States and this collection documents the organization of the women’s history week celebration in Greenville, SC from 1982-1985.

Bankhead Family Papers - Accession 594, Bankhead Family, Beard Storment Bankhead

Manuscript Collection

The Bankhead Family Papers contains personal correspondence and financial correspondence, Beard Storment “B. S.” Bankhead (1892-1973) papers relating to his magistracy, papers relating to insurance, mortgages and loans, legal papers, receipts, cancelled checks, photographs and miscellaneous papers relating to the Bankhead Family of Chester County.

Ebenezer Presbyterian Church Of Rock Hill, South Carolina Records - Accession 700, Ebenezer Presbyterian Church

Manuscript Collection

This collection consists of records and historical information, pertaining to the Ebenezer Presbyterian Church of Rock Hill, South Carolina. The collection also contains information in family history, general history of the Rock Hill area and brief histories of related Presbyterian Churches of York, Chester and Lancaster counties. Ebenezer Presbyterian Church was founded around 1785 in what was then known as Ebenezerville, SC

Evening Herald Photographs - Accession 626, Evening Herald, Rock Hill Herald

Manuscript Collection

This Evening Herald Photograph Collection consists of positive prints and negatives. The photographs were used in news stories published by the Rock Hill, SC newspaper, the Evening Herald (Rock Hill Herald). The positive print photographs were printed without emulsion and are degrading quickly. The photographs depict people, events, and places in the area and include Rock Hill, Fort Mill, Chester, Clover, and York scenes. There are photographs of area churches, landmarks, identified and unidentified people, mayors of Rock Hill. They also show scenes from Mrs. Lyndon B. “Lady Bird” Johnson, Astronaut, Charles M. Duke, I. DeQuincey Newman, and Richard Nixon’s …

Junior Keystone Club Records - Accession 1759, Junior Keystone Club Of Rock Hill, Book Club Of Rock Hill, Junior Keystone

Manuscript Collection

The Junior Keystone Club Records document the history and activities of the Junior Keystone Club of Rock Hill, South Carolina, a women’s book club organized in 1955 by members of the Keystone Club of Rock Hill. Founded with the purpose of fostering intellectual growth and civic engagement, the Junior Keystone Club sought to advance the cultural, educational, and social interests of its members through the study and appreciation of books, while also promoting community involvement and civic welfare.

The collection spans from 1955 to 2014 and consists primarily of three bound volumes containing both original and reproduced materials. Included are …

Developing And Implementing A Sexually Transmitted Disease Screening Program To Decrease Chlamydia Cases On A College Campus, Amanda C. Harris

All Capstone Projects

Introduction: Sexually active college students were experiencing a high incidence, spread, and reinfection of the sexually transmitted Disease (STD) chlamydia on a university campus.
Purpose: To determine if implementing of a quality improvement program on campus utilizing a holistic approach would help decrease chlamydia cases. This program focused on fast-track STD screening, increasing knowledge about STDs, and addressing mental health issues.
Methods & Study Design: This was a descriptive/quasi-experimental design. Participants utilized the fast-track STD screening and completed surveys. Descriptive statistics and frequency tables were used to summarize survey responses for 1) the pre-and post-sexually transmitted disease (STD) education survey, …

Hampton Mcneely Jarrell Papers - Accession 1697, Hampton Mcneely Jarrell

Manuscript Collection

This collection consists of Dr. Jarrell’s draft compilation for the book, As Felt in the Hearts, a collection of poems written by Confederate Civil War era poets. These papers includes poems selected for the final draft as well as poems considered, but not selected. Along with the manuscript draft is a signed copy of the book, Songs of the Heart, by Cora Hardin. The papers include articles written by Hampton Jarrell on York County in the American Revolution and a signed book, Wade Hampton and the Negro, by Hampton Jarrell.

G. Donald Harrison Papers - Accession 1548, G. Donald Harrison

Manuscript Collection

The papers originally belonged to G. Donald Harrison (1889-1956), a notable organ designer and president of the Aeolian-Skinner Organ Company. G. Donald Harrison designed and built the D.B. Johnson Memorial Organ in Byrnes Auditorium in 1955. The collection includes photos, correspondence, journal articles, news clippings, an opus list of Aeolian-Skinner Organ Company, programs, pamphlets, and birth certificates. The majority of these are original copies. The collection also includes a set of vinyl records, two bound volumes, two DVDs, and a WWI dog tag.