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Articles 116131 - 116160 of 1440399
Full-Text Articles in Entire DC Network
The Employment Situation Of Veterans: May 2024, Institute For Veterans And Military Families At Syracuse University
The Employment Situation Of Veterans: May 2024, Institute For Veterans And Military Families At Syracuse University
Institute for Veterans and Military Families
In May 2024, overall employment increased by 272,000 with a stable unemployment rate of 4.0%. Employment gains were notable in health care, government, leisure and hospitality, and professional services. Unemployment rates among veterans varied by age and demographic groups, showing disparities compared to nonveterans, such as higher rates among veterans aged 25-34 and lower rates among veterans aged 18-24 compared to their nonveteran peers.
3d Printing Of Fiber-Reinforced Calcined Clay-Limestone-Based Cementitious Materials: From Mixture Design To Printability Evaluation, Haodao Li, Jingjie Wei, Kamal H. Khayat
3d Printing Of Fiber-Reinforced Calcined Clay-Limestone-Based Cementitious Materials: From Mixture Design To Printability Evaluation, Haodao Li, Jingjie Wei, Kamal H. Khayat
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Sustainability and limitations in embedded reinforcement are the main obstacles in digital fabrication with concrete. This study proposed a 3D printable fiber-reinforced calcined clay-limestone-based cementitious material (FR-LC3). The binder systems incorporating calcined clay (CC) and limestone filler (LF) were optimized by determining the flow characteristics and water retention ability of the paste. The effect of fiber volume on the key fresh and mechanical properties of the fiber-reinforced mortars made with the optimized binder was evaluated. A combination of offline assessments and inline printing were employed to investigate the printability of the FR-LC3 with various binder systems and viscosity-modifying admixture (VMA) …
Forecasting Future Research Trends In The Construction Engineering And Management Domain Using Machine Learning And Social Network Analysis, Gasser G. Ali, Islam H. El-Adaway, Muaz O. Ahmed, Radwa Eissa, Mohamad Abdul Nabi, Tamima Elbashbishy, Ramy Khalef
Forecasting Future Research Trends In The Construction Engineering And Management Domain Using Machine Learning And Social Network Analysis, Gasser G. Ali, Islam H. El-Adaway, Muaz O. Ahmed, Radwa Eissa, Mohamad Abdul Nabi, Tamima Elbashbishy, Ramy Khalef
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Construction Engineering and Management (CEM) is a broad domain with publications covering interrelated subdisciplines and considered a key source of knowledge sharing. Previous studies used scientometric methods to assess the current impact of CEM publications; however, there is a need to predict future citations of CEM publications to identify the expected high-impact trends in the future and guide new research efforts. To tackle this gap in the literature, the authors conducted a study using Machine Learning (ML) algorithms and Social Network Analysis (SNA) to predict CEM-related citation metrics. Using a dataset of 93,868 publications, the authors trained and tested two …
Phases And Dynamics Of Few Fermionic Impurities Immersed In Two-Dimensional Boson Droplets, Jose Carlos Pelayo, Thomás Fogarty, Thomas Busch, Simeon I. Mistakidis
Phases And Dynamics Of Few Fermionic Impurities Immersed In Two-Dimensional Boson Droplets, Jose Carlos Pelayo, Thomás Fogarty, Thomas Busch, Simeon I. Mistakidis
Physics Faculty Research & Creative Works
We unravel the ground state properties and emergent nonequilibrium dynamics of a mixture consisting of a few spin-polarized fermions embedded in a two-dimensional bosonic quantum droplet. For an increasingly attractive droplet-fermion interaction we find a transition from a spatially delocalized fermion configuration to a state where the fermions are highly localized and isolated. This process is accompanied by the rise of induced fermion-fermion interactions mediated by the droplet. Additionally, for increasing attractive droplet-fermion coupling, undulations in the droplet density occur in the vicinity of the fermions manifesting the back-action of the latter. Following interaction quenches from strong to weaker attractive …
Exploring The Role Of Construction Technology Copilots, James S. Thielmann Jr.
Exploring The Role Of Construction Technology Copilots, James S. Thielmann Jr.
Construction Management
In the rapidly evolving construction industry, the adoption of software solutions is essential for enhancing efficiency, reducing costs, and ensuring timely project delivery. This paper assesses the effectiveness and usefulness of existing construction software solutions, focusing on their functionalities, strengths, and limitations. Among the prominent solutions gaining traction are Trunk.Tools, Constructable.ai, and ProjectEngineer.ai. The construction industry, although historically slower to adopt new technologies, stands to gain a great deal from these tools in terms of project management and performance. This research includes a thorough examination of ProjectEngineer.ai's reach in the market, feature development, and growing uptake among experts in the …
A New Design Strategy For Sizes Of Polymer Gel Treatments Derived From A Comprehensive Assessment Of Their Case Histories, Munqith Aldhaheri, Abdullah Almansour, Na Zhang, Mingzhen Wei, Baojun Bai
A New Design Strategy For Sizes Of Polymer Gel Treatments Derived From A Comprehensive Assessment Of Their Case Histories, Munqith Aldhaheri, Abdullah Almansour, Na Zhang, Mingzhen Wei, Baojun Bai
Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works
The incentive to revive brownfield oil production extends the interest to apply polymer gel treatments in injection wells. Virtually, volumes of previous remediations implemented in similar reservoir types are used to size new jobs. Such an analogy-Based design procedure imposes a need to evaluate the most frequent designs for each reservoir type based on a comprehensive field survey. This survey provides a new treatment sizing strategy for polyacrylamide-polymer bulk gels by reviewing their field applications in 653 injection wells. the new strategy proposes using the average and most frequent gel volumes per reservoir type as an initial estimate of the …
Maximizing Network Throughput In Heterogeneous Uav Networks, Shuyue Li, Jing Li, Chaocan Xiang, Wenzheng Xu, Jian Peng, Ziming Wang, Weifa Liang, Xinwei Yao, Xiaohua Jia, Sajal K. Das
Maximizing Network Throughput In Heterogeneous Uav Networks, Shuyue Li, Jing Li, Chaocan Xiang, Wenzheng Xu, Jian Peng, Ziming Wang, Weifa Liang, Xinwei Yao, Xiaohua Jia, Sajal K. Das
Computer Science Faculty Research & Creative Works
In this paper we study the deployment of an Unmanned Aerial Vehicle (UAV) network that consists of multiple UAVs to provide emergent communication service for people who are trapped in a disaster area, where each UAV is equipped with a base station that has limited computing capacity and power supply, and thus can only serve a limited number of people. Unlike most existing studies that focused on homogeneous UAVs, we consider the deployment of heterogeneous UAVs where different UAVs have different computing capacities. We study a problem of deploying K heterogeneous UAVs in the air to form a temporarily connected …
An Editorial For The Special Issue “Processing And Application Of Weather Radar Data”, Youcun Qi, Zhe Zhang, Zhanfeng Zhao, Bong Chul Seo, Huiqi Li
An Editorial For The Special Issue “Processing And Application Of Weather Radar Data”, Youcun Qi, Zhe Zhang, Zhanfeng Zhao, Bong Chul Seo, Huiqi Li
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
No abstract provided.
Application Of Multidisciplinary Community Resilience Modeling To Reduce Disaster Risk: Building Back Better, Wanting "Lisa" Wang, John W. Van De Lindt, Blythe Johnston, P. Shane Crawford, Guirong Grace Yan, Thang Dao, Trung Do, Katie Skakel, Mojtaba Harati, Tu Nguyen, Robinson Umeike, Silvana Croope, Andre R. Barbosa
Application Of Multidisciplinary Community Resilience Modeling To Reduce Disaster Risk: Building Back Better, Wanting "Lisa" Wang, John W. Van De Lindt, Blythe Johnston, P. Shane Crawford, Guirong Grace Yan, Thang Dao, Trung Do, Katie Skakel, Mojtaba Harati, Tu Nguyen, Robinson Umeike, Silvana Croope, Andre R. Barbosa
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
From december 10 to december 11, 2021, a deadly tornado outbreak struck across several states in the us, including arkansas, illinois, kentucky, and tennessee. This tornado outbreak resulted in at least $3.9 Billion in damage, more than 90 fatalities, and hundreds of injuries. Mayfield, kentucky, a small city in the eastern united states, was hit by a long-track tornado rated as an enhanced fujita 4 (ef4) scale and was one of the communities most heavily damaged during the tornado outbreak. Following the 2021 tornado event, an analysis was performed in the interdependent networked community resilience modeling environment (in-core) for the …
Efemp1 Haploinsufficiency Causes A Marfan-Like Hereditary Connective Tissue Disorder, Irman Forghani, Steven H Lang, Matthew J Rodier, Stephanie A Bivona, Alejo A Morales, Stephan Zuchner, Guney Bademci, Mustafa Tekin
Efemp1 Haploinsufficiency Causes A Marfan-Like Hereditary Connective Tissue Disorder, Irman Forghani, Steven H Lang, Matthew J Rodier, Stephanie A Bivona, Alejo A Morales, Stephan Zuchner, Guney Bademci, Mustafa Tekin
Faculty, Staff and Students Publications
Phenotypic features of a hereditary connective tissue disorder, including craniofacial characteristics, hyperextensible skin, joint laxity, kyphoscoliosis, arachnodactyly, inguinal hernia, and diverticulosis associated with biallelic pathogenic variants in EFEMP1 have been previously described in four patients. Genome sequencing on a proband and her mother with comparable phenotypic features revealed that both patients were heterozygous for a stop-gain variant c.1084C>T (p.Arg362*). Complementary RNA-seq on fibroblasts revealed significantly reduced levels of mutant EFEMP1 transcript. Considering the absence of other molecular explanations, we extrapolated that EFEMP1 could be the cause of the patient's phenotypes. Furthermore, nonsense-mediated decay was demonstrated for the mutant allele …
Genetic Evaluation For Monogenic Disorders Of Low Bone Mass And Increased Bone Fragility: What Clinicians Need To Know, Emily Busse, Brendan Lee, Sandesh C S Nagamani
Genetic Evaluation For Monogenic Disorders Of Low Bone Mass And Increased Bone Fragility: What Clinicians Need To Know, Emily Busse, Brendan Lee, Sandesh C S Nagamani
Faculty, Staff and Students Publications
Purpose of review: The purpose of this review is to outline the principles of clinical genetic testing and to provide practical guidance to clinicians in navigating genetic testing for patients with suspected monogenic forms of osteoporosis.
Recent findings: Heritability assessments and genome-wide association studies have clearly shown the significant contributions of genetic variations to the pathogenesis of osteoporosis. Currently, over 50 monogenic disorders that present primarily with low bone mass and increased risk of fractures have been described. The widespread availability of clinical genetic testing offers a valuable opportunity to correctly diagnose individuals with monogenic forms of osteoporosis, thus instituting …
Rural Veterans With Hiv And Alcohol Use Disorder Receive Less Video Telehealth Than Urban Veterans, Alan Z Sheinfil, Giselle Day, Annette Walder, Julianna Hogan, Thomas P Giordano, Jan Lindsay, Anthony Ecker
Rural Veterans With Hiv And Alcohol Use Disorder Receive Less Video Telehealth Than Urban Veterans, Alan Z Sheinfil, Giselle Day, Annette Walder, Julianna Hogan, Thomas P Giordano, Jan Lindsay, Anthony Ecker
Faculty, Staff and Students Publications
Purpose: Alcohol use disorder (AUD) is highly prevalent among Veterans with HIV. Rural Veterans with HIV are at especially high risk for not receiving appropriate treatment. This retrospective cohort cross-sectional study aimed to investigate patterns of mental health treatment utilization across delivery modality among Veterans diagnosed with HIV and AUD. It was hypothesized that rural Veterans with HIV and AUD would receive a lower rate of mental health treatment delivered via video telehealth than urban Veterans with HIV and AUD.
Methods: A national Veterans Health Association administrative database was used to identify a cohort of Veterans diagnosed with HIV and …
Cadherin-11 Targeted Cell-Specific Liposomes Enabled Skin Fibrosis Treatment By Inducing Apoptosis, Himanshu N Bhatt, Rimpy Diwan, Igor L Estevao, Rui Dong, Jennifer Smith, Chuan Xiao, Sandeep K Agarwal, Md Nurunnabi
Cadherin-11 Targeted Cell-Specific Liposomes Enabled Skin Fibrosis Treatment By Inducing Apoptosis, Himanshu N Bhatt, Rimpy Diwan, Igor L Estevao, Rui Dong, Jennifer Smith, Chuan Xiao, Sandeep K Agarwal, Md Nurunnabi
Faculty, Staff and Students Publications
Continuous and aberrant activation of myofibroblasts is the hallmark of pathological fibrosis (e.g., abnormal wound healing). The deposition of excessive extracellular matrix (ECM) components alters or increases the stiffness of tissue and primarily accounts for multiple organ dysfunctions. Among various proteins, Cadherin-11 (CDH11) has been reported to be overexpressed on myofibroblasts in fibrotic tissues. Anti-apoptotic proteins such as (B cell lymphoma-2) (BCL-2) are also upregulated on myofibroblasts. Therefore, we hypothesize that CDH11 could be a targeted domain for cell-specific drug delivery and targeted inhibition of BCL-2 to ameliorate the development of fibrosis in the skin. To prove our hypothesis, we …
Convolutional Neural Networks To Study Contrast-Enhanced Magnetic Resonance Imaging-Based Skeletal Calf Muscle Perfusion In Peripheral Artery Disease, Bijen Khagi, Tatiana Belousova, Christina M Short, Addison A Taylor, Jean Bismuth, Dipan J Shah, Gerd Brunner
Convolutional Neural Networks To Study Contrast-Enhanced Magnetic Resonance Imaging-Based Skeletal Calf Muscle Perfusion In Peripheral Artery Disease, Bijen Khagi, Tatiana Belousova, Christina M Short, Addison A Taylor, Jean Bismuth, Dipan J Shah, Gerd Brunner
Faculty, Staff and Students Publications
Peripheral artery disease (PAD) is associated with impaired blood flow in the lower extremities and histopathologic changes of the skeletal calf muscles, resulting in abnormal microvascular perfusion. We studied the use of convolution neural networks (CNNs) to differentiate patients with PAD from matched controls using perfusion pattern features from contrast-enhanced magnetic resonance imaging (CE-MRI) of the skeletal calf muscles. We acquired CE-MRI based skeletal calf muscle perfusion in 56 patients (36 patients with PAD and 20 matched controls). Microvascular perfusion imaging was performed after reactive hyperemia at the midcalf level, with a temporal resolution of 409 ms. We analyzed perfusion …
Associations Between Social Determinants Of Health And Cardiovascular Health Of Us Adult Cancer Survivors, Danish Iltaf Satti, Jeffrey Shi Kai Chan, Edward Christopher Dee, Yan Hiu Athena Lee, Abraham Ka Chung Wai, Sourbha S Dani, Salim S Virani, Michael D Shapiro, Garima Sharma, Tong Liu, Gary Tse
Associations Between Social Determinants Of Health And Cardiovascular Health Of Us Adult Cancer Survivors, Danish Iltaf Satti, Jeffrey Shi Kai Chan, Edward Christopher Dee, Yan Hiu Athena Lee, Abraham Ka Chung Wai, Sourbha S Dani, Salim S Virani, Michael D Shapiro, Garima Sharma, Tong Liu, Gary Tse
Faculty, Staff and Students Publications
Background: Relationships between the social determinants of health (SDOH) and cardiovascular health (CVH) of cancer survivors are underexplored.
Objectives: This study sought to investigate associations between the SDOH and CVH of adult cancer survivors.
Methods: Data from the U.S. National Health Interview Survey (2013-2017) were used. Participants reporting a history of cancer were included, excluding those with only nonmelanotic skin cancer, or with missing data for any domain of SDOH or CVH. SDOH was quantified with a 6-domain, 38-item score, consistent with the Centers for Disease Control and Prevention recommendations (higher score indicated worse deprivation). CVH was quantified based on …
Risk Factors For Early Mortality From Lung Cancer: Evolution Over The Last 20 Years In The French Nationwide Kbp Cohorts, T C T Hoang, D Debieuvre, A-S Bravard, S Martinez, G Le Garff, S Jeandeau, L Petit, D Marquette, K Amrane, P Demontrond, M Tiercin, B Jarjour, A Turlotte, P Masson, M Jaafar, P-A Hauss, H Morel
Risk Factors For Early Mortality From Lung Cancer: Evolution Over The Last 20 Years In The French Nationwide Kbp Cohorts, T C T Hoang, D Debieuvre, A-S Bravard, S Martinez, G Le Garff, S Jeandeau, L Petit, D Marquette, K Amrane, P Demontrond, M Tiercin, B Jarjour, A Turlotte, P Masson, M Jaafar, P-A Hauss, H Morel
Faculty, Staff and Students Publications
BACKGROUND: The impact of the most recent advances, including targeted therapies and immune checkpoint inhibitors, on early (3-month) mortality in lung cancer is unknown. The aims of this study were to evaluate the real-world rate of and risk factors for early mortality, as well as trends in early mortality over the last 20 years.
MATERIALS AND METHODS: The KBP prospective observational multicenter studies have been conducted every 10 years since 2000. These studies collect data on all newly diagnosed patients with lung cancer (all stages and histologies) over 1 year in non-academic public hospital pulmonology or oncology units in France. …
Myocardial Infarction Suppresses Protein Synthesis And Causes Decoupling Of Transcription And Translation, Shijie Liu, Vaibhav Deshmukh, Fangfei Wang, Jie Liang, Jenna Cusick, Xiao Li, James F Martin
Myocardial Infarction Suppresses Protein Synthesis And Causes Decoupling Of Transcription And Translation, Shijie Liu, Vaibhav Deshmukh, Fangfei Wang, Jie Liang, Jenna Cusick, Xiao Li, James F Martin
Faculty, Staff and Students Publications
Gene expression involves transcription, translation, and mRNA and protein degradation. Advanced RNA sequencing measures mRNA levels for cell state assessment, but mRNA level does not fully reflect protein level. Identifying heart cell proteomes and their stress response is crucial. Using a cardiomyocyte-specific mouse model, we tracked protein synthesis after myocardial infarction. Our results showed that myocardial infarction suppresses protein synthesis and unveils a decoupling of translation and transcription regulation in cardiomyocytes.
Humanism Rounds: A Multifaceted "Back To Bedside" Initiative To Improve Meaning At Work For Internal Medicine Residents, Jennifer M Kaplan, Suchi Agrawal, Disha Kumar, Ann Xu, Kristen A Staggers, Anna G Symmes, Reina U Styskel, Brett Styskel, Anoop Agrawal, Stacey R Rose
Humanism Rounds: A Multifaceted "Back To Bedside" Initiative To Improve Meaning At Work For Internal Medicine Residents, Jennifer M Kaplan, Suchi Agrawal, Disha Kumar, Ann Xu, Kristen A Staggers, Anna G Symmes, Reina U Styskel, Brett Styskel, Anoop Agrawal, Stacey R Rose
Faculty, Staff and Students Publications
INTRODUCTION: Burnout is an increasingly prevalent problem among resident physicians. To address this problem, the Accreditation Council on Graduate Medical Education (ACGME) created the Back to Bedside initiative, supporting resident-driven projects focused on increasing direct interactions with patients. In 2017, Baylor College of Medicine (BCM) Internal Medicine Residency received a Back to Bedside grant to develop and implement “Humanism Rounds,” a multifaceted program which sought to promote personal connections between residents and patients and foster reflection about patients’ non-clinical stories, with the hopes of reducing burnout and increasing residents’ sense of meaning at work.
MATERIALS AND METHODS: Between 2018 and …
Kcnk1 Promotes Proliferation And Metastasis Of Breast Cancer Cells By Activating Lactate Dehydrogenase A (Ldha) And Up-Regulating H3k18 Lactylation, Xiangchan Hou, Jiawei Ouyang, Le Tang, Pan Wu, Xiangying Deng, Qijia Yan, Lei Shi, Songqing Fan, Chunmei Fan, Can Guo, Qianjin Liao, Yong Li, Wei Xiong, Guiyuan Li, Zhaoyang Zeng, Fuyan Wang
Kcnk1 Promotes Proliferation And Metastasis Of Breast Cancer Cells By Activating Lactate Dehydrogenase A (Ldha) And Up-Regulating H3k18 Lactylation, Xiangchan Hou, Jiawei Ouyang, Le Tang, Pan Wu, Xiangying Deng, Qijia Yan, Lei Shi, Songqing Fan, Chunmei Fan, Can Guo, Qianjin Liao, Yong Li, Wei Xiong, Guiyuan Li, Zhaoyang Zeng, Fuyan Wang
Faculty, Staff and Students Publications
Breast cancer is the most prevalent malignancy and the most significant contributor to mortality in female oncology patients. Potassium Two Pore Domain Channel Subfamily K Member 1 (KCNK1) is differentially expressed in a variety of tumors, but the mechanism of its function in breast cancer is unknown. In this study, we found for the first time that KCNK1 was significantly up-regulated in human breast cancer and was correlated with poor prognosis in breast cancer patients. KCNK1 promoted breast cancer proliferation, invasion, and metastasis in vitro and vivo. Further studies unexpectedly revealed that KCNK1 increased the glycolysis and lactate production in …
Two Cases Of Pigmented Basal Cell Carcinoma In African American Patients, Angelique Ruml, Joan K Fernandez, Ibeth Caceres, Nisha Ramani, Ida Orengo, Theodore Rosen
Two Cases Of Pigmented Basal Cell Carcinoma In African American Patients, Angelique Ruml, Joan K Fernandez, Ibeth Caceres, Nisha Ramani, Ida Orengo, Theodore Rosen
Faculty, Staff and Students Publications
Basal cell carcinoma (BCC) is the most common cutaneous malignancy, comprising approximately 80% of non-melanoma skin cancers. There are numerous subtypes, including pigmented basal cell carcinoma (pBCC), a rare clinical and histological variant. Skin cancers in African American patients, although rare, still do occur. BCC is an uncommon neoplasm in this population, but when it does occur, pigmentation is present in more than 50% of tumors compared with only 5% to 6% of BCCs in Caucasians. This report presents two cases of histologically verified pBCC in African American patients from dermatology clinics at the Veterans Affairs Hospital located in the …
Challenges And Implications For Substance Use And Mental Healthcare Among Under-Resourced Women In The Covid-19 Era, Maria C Mejia, Alicia Kowalchuk, Sandra J Gonzalez, Muktha Nair, Lisa Webb, Nadine Scamp
Challenges And Implications For Substance Use And Mental Healthcare Among Under-Resourced Women In The Covid-19 Era, Maria C Mejia, Alicia Kowalchuk, Sandra J Gonzalez, Muktha Nair, Lisa Webb, Nadine Scamp
Faculty, Staff and Students Publications
BACKGROUND: The COVID-19 pandemic exacerbated disparities in mental healthcare and substance use disorder (SUD) treatment access, especially in under-resourced communities. This study aimed to comprehend the experiences of under-resourced women with SUD during the pandemic, their knowledge and attitudes toward it, and its impact on substance use and treatment access.
METHODS: A cross-sectional study included 66 under-resourced women receiving medically managed withdrawal treatment at a community residential SUD center. Data collection occurred between November 2021 and August 2022, utilizing a 75-item instrument covering COVID-19 exposure and its impact on health, substance use, treatment access, vaccination status, beliefs, and knowledge. Descriptive …
Covid-19 Ethics: Unique Aspects And A Review As Of Early 2024, Wayne X Shandera
Covid-19 Ethics: Unique Aspects And A Review As Of Early 2024, Wayne X Shandera
Faculty, Staff and Students Publications
COVID-19 presents a variety of ethical challenges in a set of arenas, arenas not always considered in past pandemics. These challenges include issues related to autonomy, distributive ethics, and the establishment of policies of equity and justice. Methods are a literature review based on regular editing of an online textbook during the COVID-19 outbreak and a literature review using key ethical terms. Patients are confronted with new issues related to autonomy. Providers need to expand their concepts of ethical issues to include decisions based on proportionality and public health ethics. The public health sector needs to assess the beneficence of …
Autologous Her2-Specific Car T Cells After Lymphodepletion For Advanced Sarcoma: A Phase 1 Trial, Meenakshi Hegde, Shoba Navai, Christopher Derenzo, Sujith K Joseph, Khaled Sanber, Mengfen Wu, Ahmed Z Gad, Katherine A Janeway, Matthew Campbell, Dolores Mullikin, Zeid Nawas, Catherine Robertson, Pretty R Mathew, Huimin Zhang, Birju Mehta, Raksha R Bhat, Angela Major, Ankita Shree, Claudia Gerken, Mamta Kalra, Rikhia Chakraborty, Sachin G Thakkar, Olga Dakhova, Vita S Salsman, Bambi Grilley, Natalia Lapteva, Adrian Gee, Gianpietro Dotti, Riyue Bao, Ahmed Hamed Salem, Tao Wang, Malcolm K Brenner, Helen E Heslop, Winfried S Wels, M John Hicks, Stephen Gottschalk, Nabil Ahmed
Autologous Her2-Specific Car T Cells After Lymphodepletion For Advanced Sarcoma: A Phase 1 Trial, Meenakshi Hegde, Shoba Navai, Christopher Derenzo, Sujith K Joseph, Khaled Sanber, Mengfen Wu, Ahmed Z Gad, Katherine A Janeway, Matthew Campbell, Dolores Mullikin, Zeid Nawas, Catherine Robertson, Pretty R Mathew, Huimin Zhang, Birju Mehta, Raksha R Bhat, Angela Major, Ankita Shree, Claudia Gerken, Mamta Kalra, Rikhia Chakraborty, Sachin G Thakkar, Olga Dakhova, Vita S Salsman, Bambi Grilley, Natalia Lapteva, Adrian Gee, Gianpietro Dotti, Riyue Bao, Ahmed Hamed Salem, Tao Wang, Malcolm K Brenner, Helen E Heslop, Winfried S Wels, M John Hicks, Stephen Gottschalk, Nabil Ahmed
Faculty, Staff and Students Publications
In this prospective, interventional phase I study (NCT00902044) for patients with advanced sarcoma, we infused autologous HER2-specific chimeric antigen receptor T-cells (HER2-CART) after lymphodepletion with cyclophosphamide (Cy) +/− fludarabine (Flu): 1×108 T-cells/m2 after Flu (cohort A) or Flu/Cy (cohort B), and 1×108 CAR-positive T-cells/m2 after Flu/Cy (cohort C). The primary outcome was assessment of safety of one dose of HER2-CART after lymphodepletion. The determination of antitumor responses was the secondary outcome. Thirteen patients were treated in 14 enrollments with 7 receiving multiple infusions. HER2-CART expanded after 19 of 21 infusions. Nine of 12 patients in cohorts A and …
Racial And Ethnic Disparities In Cardiovascular Disease – Analysis Across Major Us National Databases, Abdul Mannan Khan Minhas, Khawaja M Talha, Dmitry Abramov, Heather M Johnson, Steve Antoine, Fatima Rodriguez, Marat Fudim, Erin D Michos, Arunima Misra, Layla Abushamat, Vijay Nambi, Gregg C Fonarow, Christie M Ballantyne, Salim S Virani
Racial And Ethnic Disparities In Cardiovascular Disease – Analysis Across Major Us National Databases, Abdul Mannan Khan Minhas, Khawaja M Talha, Dmitry Abramov, Heather M Johnson, Steve Antoine, Fatima Rodriguez, Marat Fudim, Erin D Michos, Arunima Misra, Layla Abushamat, Vijay Nambi, Gregg C Fonarow, Christie M Ballantyne, Salim S Virani
Faculty, Staff and Students Publications
Background: There are several studies that have analyzed disparities in cardiovascular disease (CVD) health using a variety of different administrative databases; however, a unified analysis of major databases does not exist. In this analysis of multiple publicly available datasets, we sought to examine racial and ethnic disparities in different aspects of CVD, CVD-related risk factors, CVD-related morbidity and mortality, and CVD trainee representation in the US.
Methods: We used National Health and Nutrition Examination Survey, National Ambulatory Medical Care Survey, National Inpatient Sample, Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research, United Network for Organ Sharing, …
Nk Cells As Powerful Therapeutic Tool In Cancer Immunotherapy, Mao Huang, Yixuan Liu, Qijia Yan, Miao Peng, Junshang Ge, Yongzhen Mo, Yumin Wang, Fuyan Wang, Zhaoyang Zeng, Yong Li, Chunmei Fan, Wei Xiong
Nk Cells As Powerful Therapeutic Tool In Cancer Immunotherapy, Mao Huang, Yixuan Liu, Qijia Yan, Miao Peng, Junshang Ge, Yongzhen Mo, Yumin Wang, Fuyan Wang, Zhaoyang Zeng, Yong Li, Chunmei Fan, Wei Xiong
Faculty, Staff and Students Publications
Background: Natural killer (NK) cells have gained considerable attention and hold great potential for their application in tumor immunotherapy. This is mainly due to their MHC-unrestricted and pan-specific recognition capabilities, as well as their ability to rapidly respond to and eliminate target cells. To artificially generate therapeutic NK cells, various materials can be utilized, such as peripheral blood mononuclear cells (PBMCs), umbilical cord blood (UCB), induced pluripotent stem cells (iPSCs), and NK cell lines. Exploiting the therapeutic potential of NK cells to treat tumors through in vivo and in vitro therapeutic modalities has yielded positive therapeutic results.
Conclusion: This review …
Chagasin From Trypanosoma Cruzi As A Molecular Scaffold To Express Epitopes Of Tsa-1 As Soluble Recombinant Chimeras, Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López
Chagasin From Trypanosoma Cruzi As A Molecular Scaffold To Express Epitopes Of Tsa-1 As Soluble Recombinant Chimeras, Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López
Faculty, Staff and Students Publications
Trypanosoma cruzi is the causative agent of Chagas disease, a global public health problem. New therapeutic drugs and biologics are needed. The TSA-1 recombinant protein of T. cruzi is one such promising antigen for developing a therapeutic vaccine. However, it is overexpressed in E. coli as inclusion bodies, requiring an additional refolding step. As an alternative, in this study, we propose the endogenous cysteine protease inhibitor chagasin as a molecular scaffold to generate chimeric proteins. These proteins will contain combinations of two of the five conserved epitopes (E1 to E5) of TSA-1 in the L4 and L6 chagasin loops. Twenty …
Plagiarism, Richard Alweis, Nagesh Jadhav
Plagiarism, Richard Alweis, Nagesh Jadhav
Rochester Regional Health authored publications and proceedings
Learning objectives:
- Plagiarism overview
- A special case: large language models (LLM) and academic writing
The Myth Of Slavery Abolition, Jocelyn Getgen Kestenbaum
The Myth Of Slavery Abolition, Jocelyn Getgen Kestenbaum
Articles
In many countries today, slavery and the slave trade continue with impunity. International human rights law prohibits both abuses, but states are rarely held accountable and people who are enslaved or slave traded rarely receive redress. This Article offers a novel account of why international human rights law advocacy neglects slavery and the slave trade. Specifically, this Article demonstrates that the abolition of the Transatlantic and East African slave trades was achieved through a legal framework that marginalized the human rights of enslaved persons while consolidating empire. In the wake of World War II, prohibitions on slavery and the slave …
Validation Of The Spanish Version Of The Ivi_C Vrqol In Children From 8 To 18 Years Old, Carlos Fresno Cañada, Joan Gispets Parcerisas, Nazaret Fresno, Héctor Salvador Hernandez, Ana Llorca Cardeñosa, Alejandro Martinez Roda, Joan Prat Bartomeu
Validation Of The Spanish Version Of The Ivi_C Vrqol In Children From 8 To 18 Years Old, Carlos Fresno Cañada, Joan Gispets Parcerisas, Nazaret Fresno, Héctor Salvador Hernandez, Ana Llorca Cardeñosa, Alejandro Martinez Roda, Joan Prat Bartomeu
Writing and Language Studies Faculty Publications
Purpose
To validate the Spanish version of the Impact of Vision Impairment for Children (IVI_C), a vision-related quality of life (VRQoL) questionnaire, using Rasch Analysis.
Methods
A translation and adaptation of the English IVI_C test was performed according to the standards published in PedsQL. The IVI_C Spanish version of the test was administered by email to 101 Sant Joan de Déu Hospital patients who were invited to respond twice, with a minimum interval of two months. The age of the patients ranged from 8 to 18 years. Statistical software SPSS 19.0 (Armonk, NY: IBM Corp.) was used to perform the …
Spanish Heritage Speakers’ Processing Of Lexical Stress, Ramsés Ortín
Spanish Heritage Speakers’ Processing Of Lexical Stress, Ramsés Ortín
Writing and Language Studies Faculty Publications
This study examines the status of lexical stress in the processing system of heritage speakers of Spanish and whether or not it is influenced by their experience with English. Participants completed an ABX matching task with auditory stimuli differing in the location of stress or in one consonantal sound. Findings reveal that heritage speakers are more accurate in consonant-based trials than in stress-based ones, but only when matching stimuli were non-adjacent, which suggests that their stress-processing strategies pattern more closely with those of native English speakers. Furthermore, dominance and knowledge of Spanish appear to be associated with increased phonological sensibility …