Digital Commons Network^™

Endothelial Knockdown Of The Tumor Suppressor, Wwox, Increases Inflammation In Ventilator-Induced Lung Injury, Zhenguo Zeng, Eltyeb Abdelwahid, Weiguo Chen, Christian Ascoli, Trinh Pham, Jeffrey R Jacobson, Steven M Dudek, Viswanathan Natarajan, C Marcelo Aldaz, Roberto F Machado, Sunit Singla

Faculty, Staff and Student Publications

Chronic cigarette smoke exposure decreases lung expression of WWOX which is known to protect the endothelial barrier during infectious models of acute respiratory distress syndrome (ARDS). Proteomic analysis of WWOX-silenced endothelial cells (ECs) was done using tandem mass tag mass spectrometry (TMT-MS). WWOX-silenced ECs as well as those isolated from endothelial cell Wwox knockout (EC Wwox KO) mice were subjected to cyclic stretch (18% elongation, 0.5 Hz, 4 h). Cellular lysates and media supernatant were harvested for assays of cellular signaling, protein expression, and cytokine release. These were repeated with dual silencing of WWOX and zyxin. Control and …

Venetoclax And Cobimetinib In Relapsed/Refractory Aml: A Phase 1b Trial, Marina Y Konopleva, Monique Dail, Naval G Daver, Jacqueline S Garcia, Brian A Jonas, Karen W L Yee, Kevin R Kelly, Norbert Vey, Sarit Assouline, Gail J Roboz, Stefania Paolini, Daniel A Pollyea, Agostino Tafuri, Joseph M Brandwein, Arnaud Pigneux, Bayard L Powell, Pierre Fenaux, Rebecca L Olin, Giuseppe Visani, Giovanni Martinelli, Maika Onishi, Jue Wang, Weize Huang, Diana R Dunshee, Habib Hamidi, Marion G Ott, Wan-Jen Hong, Michael Andreeff

Faculty, Staff and Student Publications

Background: Therapies for relapsed/refractory acute myeloid leukemia remain limited and outcomes poor, especially amongst patients who are ineligible for cytotoxic chemotherapy or targeted therapies.

Patients and methods: This phase 1b trial evaluated venetoclax, a B-cell lymphoma-2 (BCL-2) inhibitor, plus cobimetinib, a MEK1/2 inhibitor, in patients with relapsed/refractory acute myeloid leukemia, ineligible for cytotoxic chemotherapy. Two-dimensional dose-escalation was performed for venetoclax dosed daily, and for cobimetinib dosed on days 1-21 of each 28-day cycle.

Results: Thirty patients (median [range] age: 71.5 years [60-84]) received venetoclax-cobimetinib. The most common adverse events (AEs; in ≥40.0% of patients) were diarrhea (80.0%), nausea (60.0%), vomiting …

Dyadic Yoga For Head And Neck Cancer Patients Undergoing Chemoradiation And Their Family Caregivers, Kathrin Milbury, David I Rosenthal, Yisheng Li, An Thuy Ngo-Huang, Smitha Mallaiah, Sania Yousuf, Clifton D Fuller, Carol Lewis, Eduardo Bruera, Lorenzo Cohen

Faculty, Staff and Student Publications

Objectives: Concurrent chemoradiation to treat head and neck cancer (HNC) may result in debilitating toxicities. Targeted exercise such as yoga therapy may buffer against treatment-related sequelae; thus, this pilot RCT examined the feasibility and preliminary efficacy of a yoga intervention. Because family caregivers report low caregiving efficacy and elevated levels of distress, we included them in this trial as active study participants.

Methods: HNC patients and their caregivers were randomized to a 15-session dyadic yoga program or a waitlist control (WLC) group. Prior to randomization, patients completed standard symptom (MDASI-HN) and patients and caregivers completed quality of life (SF-36) assessments. …

Forecasting Acute Kidney Injury And Resource Utilization In Icu Patients Using Longitudinal, Multimodal Models, Yukun Tan, Merve Dede, Vakul Mohanty, Jinzhuang Dou, Holly Hill, Elmer Bernstam, Ken Chen

Faculty, Staff and Student Publications

Background: Advances in artificial intelligence (AI) have realized the potential of revolutionizing healthcare, such as predicting disease progression via longitudinal inspection of Electronic Health Records (EHRs) and lab tests from patients admitted to Intensive Care Units (ICU). Although substantial literature exists addressing broad subjects, including the prediction of mortality, length-of-stay, and readmission, studies focusing on forecasting Acute Kidney Injury (AKI), specifically dialysis anticipation like Continuous Renal Replacement Therapy (CRRT) are scarce. The technicality of how to implement AI remains elusive.

Objective: This study aims to elucidate the important factors and methods that are required to develop effective predictive models of …

Developing A Computational Representation Of Human Physical Activity And Exercise Using Open Ontology-Based Approach: A Tai Chi Use Case, Eloisa Nguyen, Rebecca Z Lin, Yang Gong, Cui Tao, Muhammad Tuan Amith

Faculty, Staff and Student Publications

Many studies have examined the impact of exercise and other physical activities in influencing the health outcomes of individuals. These physical activities entail an intricate sequence and series of physical anatomy, physiological movement, movement of the anatomy, etc. To better understand how these components interact with one another and their downstream impact on health outcomes, there needs to be an information model that conceptualizes all entities involved. In this study, we introduced our early development of an ontology model to computationally describe human physical activities and the various entities that compose each activity. We developed an open-sourced biomedical ontology called …

A New Computed Tomography Score-Based Staging For Melioidosis Pneumonia To Predict Progression, Yang Chen, Dehuai He, Yehua Wu, Xiangying Li, Kaifu Yang, Yuefu Zhan, Jianqiang Chen, Xiaobo Zhou

Faculty, Staff and Student Publications

infectious disease prevalent in tropical regions. Chest computed tomography (CT) has emerged as a valuable tool for assessing the severity and progression of lung involvement in melioidosis pneumonia. However, there persists a need for the quantitative assessment of CT characteristics and staging methodologies to precisely anticipate disease progression. This study aimed to quantitatively extract CT features and evaluate a CT score-based staging system in predicting the progression of melioidosis pneumonia.

Methods: This study included 97 patients with culture-confirmed melioidosis pneumonia who presented between January 2002 and December 2021. Lung segmentation and annotation of lesions (consolidation, nodules, and cavity) were used …

Clinical Information Retrieval: A Literature Review, Sonish Sivarajkumar, Haneef Ahamed Mohammad, David Oniani, Kirk Roberts, William Hersh, Hongfang Liu, Daqing He, Shyam Visweswaran, Yanshan Wang

Faculty, Staff and Student Publications

UNLABELLED: Clinical information retrieval (IR) plays a vital role in modern healthcare by facilitating efficient access and analysis of medical literature for clinicians and researchers. This scoping review aims to offer a comprehensive overview of the current state of clinical IR research and identify gaps and potential opportunities for future studies in this field. The main objective was to assess and analyze the existing literature on clinical IR, focusing on the methods, techniques, and tools employed for effective retrieval and analysis of medical information. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted an …

Ai Competency Acquisition Online? Engaging Undergraduate Students In An Ai 101 Course Through A Chatbot Workshop, Thomas Menkhoff, Lydia Teo

Research Collection Lee Kong Chian School Of Business

In recent years, digital transformation has dominated industries at an unprecedented rate. Alongside the proliferation of Artificial ntelligence (AI) technologies in the workplace, institutions of higher learning are experiencing an unprecedented push to integrate AI into the education ecosystem (Popenici & Kerr, 2017; Renz & Hilbig, 2020). AI in education (AIED) has the propensity to enrich teaching and learning in higher education by personalising students’ learning courses, automating assessment tasks, or providing24/7 access to learning resources (Karandish, 2021). According to estimates by the AI Market in the US Education Report, the AIEDmarket will grow at a CAGR of 47.77% during …

Spring Migration Ecology Of Snow Buntings In Southwest Yukon Territory, 2014-2023, Cyndi M. Smith, Julie Bauer, Terry Skjonsbert

North American Bird Bander

No abstract provided.

A New Longevity Record For The Seaside Sparrow And Documentation Of Its Successful Reproduction, Phillip L. Vasseur

North American Bird Bander

No abstract provided.

North American Bird Banding Program Longevity Records, Lauren Walker, Matthew Rogosky, Kyra Harvey

North American Bird Bander

No abstract provided.

2023 Atlantic Flyway Review (Fall Migration), Aaron Given

North American Bird Bander

No abstract provided.

Species Snapshot: Brown-Headed Cowbird (Molothrus Ater)- 1959 And Earlier, Steven Gabrey

North American Bird Bander

No abstract provided.

2023-2024 Wbba Webinar Series Presentations, Danielle Kaschube

North American Bird Bander

No abstract provided.

Inland Flyway Review Maps 2023, Steven Gabrey

North American Bird Bander

No abstract provided.

Front Matter, North American Bird Bander

North American Bird Bander

No abstract provided.

Back Matter, North American Bird Bander

North American Bird Bander

No abstract provided.

Implicit Commitments To Workplace Environment And Corporate Information Production: Evidence From Indoor Environment Quality, Summer Rui Huang, Leonard Leye Li, Louise Yi Lu, Rencheng Wang

Research Collection School Of Accountancy

This study investigates the effect of a firm’s indoor environment quality (IEQ) on its information production. Leveraging a third-party sustainability building rating system that provides IEQ scores for office buildings, we first show that employees in a firm’s headquarters with better IEQ scores are more likely to leave positive building-related feedback on Glassdoor, indicating employees’ recognition and appreciation of a workplace with superior IEQ. Next, we find robust evidence that firms headquartered in buildings with better IEQ issue more frequent and more accurate management forecasts. Furthermore, we show that a firm’s commitment to better IEQ (1) enhances occupational wellbeing of …

Leader-Expressed Humility: Development And Validation Of Scales Based On A Comprehensive Conceptualization, Kraivin Chintakananda, James M. Diefendorff, Burak Oc, Michael A. Daniels, Gary J. Greguras, Michael R. Bashshur

Research Collection Lee Kong Chian School Of Business

We introduce new leader humility scales capturing a theoretically rich conceptualization of leader-expressed humility aligned with traditional and ethically-grounded philosophies. These scales draw from recent inductive research (Oc et al., 2015) identifying nine dimensions of leader-expressed humility: (1) having an accurate view of self, (2) recognizing follower strengths and achievements, (3) modeling teachability and being correctable, (4) leading by example, (5) showing modesty, (6) working together for the collective good, (7) empathy and approachability, (8) showing mutual respect and fairness, and (9) mentoring and coaching. The first three dimensions overlap with the most prominent conceptualization of leader-expressed humility in the …

Job Insecurity And Well-Being: Integrating Life History And Transactional Stress Theories, Nina Sirola

Research Collection Lee Kong Chian School Of Business

The current research proposes and tests a novel model explaining how job insecurity shapes well-being and has consequences for stratification and inequality. I draw on evolutionary life history theory, which proposes that growing up in a poorer versus wealthier environment impacts the sense of control people feel when exposed to threat in adulthood. I integrate this perspective with transactional stress theory to propose that job insecurity has a disproportionately negative effect on employees from poorer backgrounds, leading to lower engagement and higher emotional exhaustion among such employees, while those from wealthier backgrounds are buffered against these effects. These responses to …

Nationalist Sentiments And The Multinational Enterprise: Insights From Organizational Sociology, Jesper Edman, Ilya R. P. Cuypers, Gokhan Ertug, Ruth V. Aguilera

Research Collection Lee Kong Chian School Of Business

International business scholars have recognized the impact of political and economic nationalism on the multinational enterprise (MNE). We complement these approaches by highlighting the sociological manifestations of nationalism and their implications for the MNE. We argue that nationalist sentiments, i.e. widely-shared assumptions of superiority over other nations and cultures, constitute an under-researched but critical element in international business (IB). Drawing insights from organizational sociology, we elucidate how nationalist sentiments manifest in the MNE’s external and internal environment. Specifically, we suggest that nationalist sentiments accentuate national institutional logics, generate status-based categorizations of foreign and domestic firms, and heighten emphasis on national …

Lessons From The Demise Of The Brent Crude Oil Futures Contract On The Singapore Exchange, Kuan Yong David Ding, Wui Boon Lim

Research Collection Lee Kong Chian School Of Business

This paper highlights the lessons drawn from the demise of the Brent Crude Oil futures contract that was traded on the Singapore Stock Exchange (SGX). We analyze the market microstructure of the contract prior to its failure—specifically, the number of trades, trading volume, open interest, bid–ask spread, and volatility. We find a steady decline in the mean volume, open interest, and number of trades as the contracts near their demise. The bid–ask spread of the contract also widens. Investigations of the mutual offset feature of the Brent Crude Oil futures contract between SGX and the International Commodity Exchange (ICE) provides …

What Drives Employers’ Favorability Ratings On Employer Review Platforms? The Role Of Symbolic, Personal, And Emotional Content, Christoph E. Höllig, Andranik Tumasjan, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Employer review platforms have changed the recruitment landscape by allowing current and former employees to post messages about an employer outside of direct company control. Therefore, they have emerged as an important form of third-party employer branding. However, we know little about how such open-ended comments relate to the key variable in employer reviews: employers’ favorability rating. Therefore, we start by situating this variable among other constructs in the employer branding space. Next, we build theory on how content in the open-ended comments of an employer review relates to the positivity or negativity of the reviews’ favorability rating. We test …

Politically Connected Emncs In A (De)Globalising World: A Review And Future Research Directions, Dongdong Huang, Lai Si Tsui-Auch, Marleen Dieleman, David Gomulya

Research Collection Lee Kong Chian School Of Business

Emerging market multinational corporations (EMNCs) have emerged as significant global players, driven by their home country political connections that present both opportunities and challenges. Despite the insights gained from current studies, we still lack a clear conceptualisation of diverse political connections and the distinctiveness of politically connected EMNCs. Our study conducts a comprehensive review to bridge those gaps. We identify and compare two types of political connections, delve into major theories and highlight their main focus, key arguments, mechanisms and outcome predictions. Consequently, we propose a context-mechanism-outcome framework across three contextual levels, emphasising theoretical convergence and divergence between politically connected …

Performance Analysis Of Hybrid Deep Learning Framework Using A Vision Transformer And Convolutional Neural Network For Handwritten Digit Recognition, Vanita Agrawal, Jayant Jagtap, Shruti Patil, Ketan Kotecha

Faculty, Staff and Student Publications

Digitization created a demand for highly efficient handwritten document recognition systems. A handwritten document consists of digits, text, symbols, diagrams, etc. Digits are an essential element of handwritten documents. Accurate recognition of handwritten digits is vital for effective communication and data analysis. Various researchers have attempted to address this issue with modern convolutional neural network (CNN) techniques. Even after training, CNN filter weights remain unchanged despite the high identification accuracy. As a result, the process cannot flexibly adapt to input changes. Hence computer vision researchers have recently become interested in Vision Transformers (ViTs) and Multilayer Perceptrons (MLPs). The shortcomings of …

Navigating Transience, Nina Liu

Masters Theses

With advancing age, does the act of collecting and collections serve a purpose? Experimental psychologist Daniel Krawczyk claims that the act of collecting is deeply embedded in how the human brain registers time. Building upon the premise of Krawczyk’s research, I delve into a journey of collecting as I trace its evolution from childhood to adulthood, and its significance amidst the rapid digitalization of the modern world.

Through the lens of the transitional object and with a commitment to the preservation of memories, this thesis examines the intricate relationship between humans and their possessions. It proposes that the intimate activity …

Building The Body, Jasmine Flowers

Masters Theses

Bodies and space co-produce each other and the process of co-production originates racializing and gendering work.

The concept, thesis, and subsequent design are informed by the historical context around the House for Josephine Baker by Adolf Loos. Presented here is the culmination of research which grounds itself in the relationship between Primitivism and Modernism, theory on the body and flesh, architectural graphic standards, spectacle, gaze, surveillance, hypervisibility, invisibility, implications of privacy versus publicity, expressions of Blackness and its place in femmehood (a neologism that expands “womanhood” to be trans-inclusive), all of which directly engage in co-production.

This co-production changes how …

Intangible Shells, Elena Bulet

Masters Theses

The following essay mimics the constant disruption of a fragmented memory. It reflects on intergenerational gendered family dynamics since the civil war and dictatorship-era Spain and how memory articulates narratives of belonging within the matrilineal lineage. A process of excavation departs from personal memories, familial archives, contemporary interviews, theoretical readings, photographic reenactments, and observations of traces in the landscape of Almayate’s town. The author attempts to retrace her roots, as well as her family history, acknowledging the impossibility of making personal histories tangible.

Sircling The Cquare, Latika Balachander

Masters Theses

As we journey into an increasingly virtual and intangible reality, is there an opportunity for our tactile fabrics to journey with, and even reorient us? Can they exist in our future worlds to remind us of the value of current traditional, low-tech practices that we may soon forget?

Referencing the fundamental fabric languages of knitted and woven structures, this collection of garments, that I term “Earthsuits,” embody the stages of metamorphosis as we adjust to a new phase of our perceptive reality. With an emphasis on circling, we loop through virtual squares like screens and pixels, to the circles of …

A Thesis, Or Digressions On Sculptural Practice: In Which, Concepts & Influences Thereof Are Explained, Set Forth, Catalogued, Or Divulged By Way Of Commentaries To A Poem, First Conceived By The Artist, Fed Through Chatg.P.T., And Re-Edited By The Artist, To Which Are Added, Annotated References, Impressions And Ruminations Thereof, Also Including Private Thoughts & Personal Accounts Of The Artist, Jaimie An

Masters Theses

This thesis is an exercise in, perhaps a futile, attempt to trace just some of the ideas, stories, and musings I might meander through in my process. It’s not quite a map, nor is it a neat catalogue; it is a haphazard collection of tickets and receipts from a travel abroad, carelessly tossed in a carry-on, only to be stashed upon returning home. These ideas are derived from much greater thinkers and authors than myself; I am a mere collector or a translator, if that, and not a very good one, for much is lost. I do not claim comprehensive …