Digital Commons Network^™

Advancing Clinical Microbiology: Applications And Future Of Next-Generation Sequencing, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Next-generation sequencing (NGS) has reformed infectious disease management, including COVID-19. While real-time polymerase chain reaction (PCR) is widely used for rapid pathogen detection, it requires predefined targets. NGS offers an unbiased approach, detecting multiple pathogens simultaneously without prior knowledge. Despite its potential, NGS implementation in clinical settings faces challenges like high costs and technical complexity. NGS platforms like Illumina, Ion Torrent, and Nanopore provide high-throughput sequencing, identifying pathogens and resistance markers. Applications include whole genome sequencing (WGS), metagenomic NGS (mNGS), and targeted NGS (tNGS). Integrating NGS with conventional methods could improve diagnostics, but current evidence is mixed for supporting its …

Exploring The Associations Of Afterschool Science Participation And Friendships With Science Identities, Patricia Wonch Hill, Grace M. Kelly, Julia Mcquillan, Jorge Ledesma, Miranda Melson, G. Robin Gauthier

Worlds of Connections Resources

Building on previous research that demonstrates the association of youth experiences in afterschool science and higher science identities, this paper presents a network study of 421 middle school students that examines afterschool science participation, friendship ties, and science identities. Participation in afterschool science clubs is associated with higher science identity, but the mechanisms and order of causality are unclear. Youth form friendships inside and outside of school, and peers may influence participation in afterschool activities, as empirical research on friendships shows that they are associated with youth interests. These peer interactions also have the potential to shape identity development during …

Development Of An Effective Predictive Screening Tool For Prostate Cancer Using The Claritydx Machine Learning Platform, M Eric Hyndman, Robert J Paproski, Adam Kinnaird, Adrian Fairey, Leonard Marks, Christian P Pavlovich, Sean A Fletcher, Roman Zachoval, Vanda Adamcova, Jiri Stejskal, Armen Aprikian, Christopher J D Wallis, Desmond Pink, Catalina Vasquez, Perrin H Beatty, John D Lewis

Faculty, Staff and Student Publications

The current prostate cancer (PCa) screen test, prostate-specific antigen (PSA), has a high sensitivity for PCa but low specificity for high-risk, clinically significant PCa (csPCa), resulting in overdiagnosis and overtreatment of non-csPCa. Early identification of csPCa while avoiding unnecessary biopsies in men with non-csPCa is challenging. We built an optimized machine learning platform (ClarityDX) and showed its utility in generating models predicting csPCa. Integrating the ClarityDX platform with blood-based biomarkers for clinically significant PCa and clinical biomarker data from a 3448-patient cohort, we developed a test to stratify patients' risk of csPCa; called ClarityDX Prostate. When predicting high risk cancer …

Gender-Targeted Substance Use Interventions For Young Cisgender Women And Transgender Women – A Scoping Review, Stephanie A. Nairn, Jason Phillips, Thomas Jones, Debbie Schmill

Faculty Scholarship and Creative Works

Polysubstance use among young people has recently become the focus of popular media, public health interventions, and research due to alarming increases in polysubstance use-related morbidity and mortality in younger age groups. Data in Canada and the U.S. indicates that morbidity and mortality due to polysubstance use among youth is increasing. Researchers have shown that adult-focused interventions for polysubstance use cannot simply be ‘mapped onto’ youth, as young people occupy lifeworlds distinct from those of older adults. Adult-focused interventions may be irrelevant and not efficacious for youth. Further, some researchers have argued there need to more gender-targeted interventions to attenuate …

Diagnosing Silent Forgiveness At The Dialogical Limit In Endō Shūsaku’S Novel Silence, Catherine Buescher

Dissertations

I situate this dissertation within the context of the rightly noted deficiencies of dialogue and dialogical hermeneutics, deficiencies that prevent dialogue from effectively addressing the pathological nature of many of today's social issues, e.g., white supremacy, sexual and gender inequality, and climate change. Using the lens and limits of Western dialogical hermeneutics as noted by David Tracy, I conduct a case study of the dialogues of the main characters - Rodrigues, Ferreira, Kichijiro, God—in Endō Shūsaku’s novel Silence, noting the silence active in each of the dialogues at the end of the novel. I then argue that the nature and …

Loverboy Rules: A Transtheoretical Exploration Of Andy Bernard's Failed Masculinity, Jessie Marta Olstad

Master's Theses

NBC's U.S adaptation of The Office is one of the most well-known sitcoms to come out of modern television, surpassing its original British counterpart’s two seasons with its own nine. It is a representation, as well, of the time it aired (2005-2013), reflecting on the modern American workplace and the everyday person. Within it, The Office also reflected how society was constructed at the time with its humor surrounding gender, homosexuality, and race – as a tolerant but not welcoming atmosphere to people who were not white, heterosexual, men. More specifically, The Office presents multiple adaptations of masculinity to teach …

Bert-Boosted Adaptive Learning, Dibyanshu Chatterjee

Theses

Knowledge Tracing is a machine learning technique that aids in monitoring a learner’s knowledge in a given learning environment. This thesis introduces a unified approach to adaptive learning, specifically with the use of Knowledge Tracing (KT) and other relevant machine learning models, that can aid in creating a personalized learning environment for a learner on an Intelligent Tutoring System (ITS). While contemporary ITS exemplars, such as Knewton and Adaptemy, strive to provide seamless adaptive learning experience, most such ITS platforms do so by employing individualized models, each tai- lored to distinct tasks, for example, some models may predict correctness of …

An Incidentally Found Mass On The Remnant Stomach After A Roux-En-Y Gastric Bypass, Jennifer E. Geller, Santosh Swaminathan, Kristin Noonan

Abington Jefferson Health Papers

BACKGROUND: Incidentally found masses are a widely discussed area of medicine, and there are conflicting opinions as to how to deal with these findings, particularly in the stomach-which has limited documentation in the literature. Here we present a middle-aged female who was found to have an incidentally found mass on her remnant stomach 10 years after a Roux-en-Y gastric bypass (RYGB) surgery.

CASE PRESENTATION: We present the case of a 66-year-old female who is 10 years post-op from a RYGB. After a bout of self-resolving diarrheal illness prompted a computed tomography (CT) scan in the emergency department, she was diagnosed …

Neuroscience And Organizational Trust: Biological Mechanisms For Enhanced Learning, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Individual representations of trust are deeply rooted in individual consciousness and serve as significant cognitive constraints, influenced by neural processes and psychiatric factors. This paper aims to highlight the often overlooked or under-operationalized role of human trust's biological agency within the context of organizational learning. From a psychiatric and neuroscience perspective, the paper proposes that through intentional management practices, the biological agency of trust, mediated by neural mechanisms, can act as a proxy for organizational learning. It suggests that adopting a more scientific approach to management, informed by an understanding of neural and psychiatric underpinnings, can enhance employee trust from …

Federal Reserve Balance Sheet: Factors Affecting Reserve Balances - H.4.1 - April 18, 2024, Federal Reserve System

Documents

No abstract provided.

Financial Stability Report 2024, Swiss National Bank

Documents

No abstract provided.

Oral History Lessons Outline, Laura Tanenbaum

Open Educational Resources

This lesson plan was developed to integrate oral history practice into an introductory composition class at LaGuardia Community College, in collaboration with the Oral History Seminar of LaGuardia's Center for Teaching and Learning in the Spring of 2024.

Examining The Effectiveness And Acceptability Of A Single-Session Problem-Solving Teleconsultation Package With Caregivers, Tiara J. Rowell

USF Tampa Graduate Theses and Dissertations

This study implemented a single case concurrent multiple baseline design to examine the effects of a single-session problem-solving teleconsultation package for behavioral caregiver training. This study sought to address a gap in the Problem-Solving Consultation (PSC) literature regarding the treatment of children’s challenging behaviors. Participants included three caregivers who received a single-session PSC through teleconsultation. The session focused on creating a Behavior Intervention Plan (BIP) in order to address their child’s challenging behaviors. The BIP was developed based on baseline data, questionnaires, and emails exchanged between the consultant and the three caregivers. Results indicated that two of the three caregivers …

Disruptions In The Experiences Of First-Time Military Family Members, Ana C. Vidal

USF Tampa Graduate Theses and Dissertations

Military service members and their families encounter many obstacles throughout their time in the military (as well as before enlistment/commission and after service), ranging from those unique to the military community to those common within civilian families. Although how military families deal with these challenges/stressors and how to better support these families has been a salient research area, there is still room for expansion of knowledge. This study argues for expanding who is included in the definition of a “military family” to include a service member’s parents/parental figures and siblings, as well as enlarging the period of interest in military …

Spatial Patterns In Anthropomorphic Fremont Rock Imagery Of Central Utah, Alyssa Pitts Merrill

Theses and Dissertations

Rock imagery from the late Fremont period (1000-1300 AD) has captivated the interest of both professional and avocational researchers for the past century. In this thesis, I apply a highly systematized method of cataloguing and analysis to 482 anthropomorphs from Clear Creek Canyon (CCC) and Grand Staircase Escalante National Monument (GSENM). The primary theoretical assumption in this thesis is that the shapes used in anthropomorphic imagery convey ideas about how the Fremont saw people. I therefore recorded the head and body morphology and presence of arms, legs, and genitalia of each anthropomorph. By observing the data spatially, I discovered both …

"Vampire Plastics": An Investigation Of Poly(Olefin Sulfone) Depolymerization And Its Dust Mitigation Abilities, Alexandra Kathryn Kanani Gallion Stapley

Theses and Dissertations

The ubiquity of particulate contamination requires dust mitigation techniques to provide low-scatter surfaces and edges on sensitive optical devices in space. Poly(olefin sulfone)s have been shown to photodegrade with the assistance of a photobase generator when exposed to UV light (254 nm) and heat (120 °C). These polymers may be useful for minimizing dust on optical surfaces for space applications. However, their behavior in vacuum has not been fully characterized. We synthesized poly(2-methyl-1-pentene sulfone) (PMPS) and poly(1-hexene sulfone) (PHS) with and without a photobase generator. We studied the photodegradation (172 nm or 254 nm) of thin films in vacuum. Spectroscopic …

Moving Slow And Fixing Things, Hannibal Travis

Faculty Publications

No abstract provided.

Daring Dames And Dirty Deeds: Chicago Burlesque, Drag, And Censorship Politics, 1850-1980, Lucas Andrew Bensley

Dissertations

"Daring Dames and Dirty Deeds" is a history of burlesque, drag and censorship politics in Chicago from 1850 to 1980. In this period, burlesque and drag entertainers and shows adapted to changes in the tastes and sensibilities of the public. In the late nineteenth and early twentieth centuries, burlesque was primarily a form of parody of "higher culture" entertainment featuring circus performers, comedians, and female dancers in elaborate costume. In Chicago, burlesque gradually changed to become an art form that pushed the boundaries of how women could perform on stage while challenging laws and cultural norms of decency and chastity. …

Tool Life Characterization In Refill Friction Stir Spot Welding, Ruth Guadalupe Belnap

Theses and Dissertations

As light-weighting becomes a priority for the automotive industry, refill friction stir spot welding emerges with enormous potential to supplement or replace conventional spot joining processes. This thesis addresses the limitations of current tooling options by examining materials beyond steel for use in RFSSW. Contained herein is an analysis of weld quality as a function of tool material, a production evaluation of RFSSW using various tool materials, and an assessment of long-term performance of a tungsten carbide tool. Over the course of this research, tungsten carbide emerged as a viable candidate for long-lasting RFSSW tooling.

Implementation Of Tai Chi Fall Prevention Program In A Community-Based Setting, Shabnampreet Kaur

Dissertations

The increasing rate of falls among older adults is a health concern that may lead to injuries and reduced quality of life. At the project site there was no systematic process to impact fall rates, so an evidence-based solution was sought. The purpose of this quality improvement project was to determine if the translation of Li et al.'s research regarding the Tai Chi fall prevention program would impact the rate of falls among adults 65 years and older. The project was piloted over 12 weeks in a community-based setting in urban New York. Imogene King's goal attainment theory and Kurt …

Examining Psychosocial Stressors Among African American Women With Postpartum Depression, Audrey Rose Morris

Walden Dissertations and Doctoral Studies

Psychosocial stressors are among the causative factors of postpartum depression (PPD) in African American women. This study was a qualitative meta-analysis examining the psychosocial stressors that contribute to PPD among African American women. The aim was to identify the psychosocial stressors among African American women with PPD by examining existing literature and identifying common themes. The integrative model (IM) by Fishbein and Yzer assisted in understanding the significance of psychosocial stressors in African American women with PPD. Thematic analysis was used to generate new, more substantive meanings than those taken from individual investigations. Ten research studies were selected and examined …

Liberating Bioethics Through Agape: A Feminist Perspective From The Periphery, Kimberly Vargas Barreto

Dissertations

Despite the vast number of cultures and peoples that reside in the West, ethical action in bioethics is determined through the perspective of la Totalidad, which does not include the Other or individuals from the periphery. In my dissertation, I argue that the universalization of U.S. clinical bioethics (la bioética estadounidense) and the coloniality of knowledge that extends from it are, at its core, imperialistic in nature and result in the exclusion of patients with intersectional identities. While clinical bioethics was first conceived as a critical tool for medicine, the acceptance of principlism as the central theory in the field …

Gender Diversity In U.S. Adolescents: An Exploration Of Multidimensional Survey Measures Of Gender And Their Associations With Health And Social Outcomes Using A National Sample Of Adolescent-Parent Dyads, Christopher Hansen

Dissertations

The measurement of gender is an evolving area of survey research. Extant research has assessed different approaches for measuring gender identity and expression among adults; however, comparatively less research has evaluated their use among adolescents who are developing their gender identity and expression. This dissertation uses data from a nationally representative survey of U.S. teens and their parents to evaluate multidimensional measures of gender in adolescents. Three research questions represent separate empirical chapters of the dissertation. The first research question examines the measurement of femininity and masculinity in adolescents based on a comparison of different survey scales. The second research …

Reconceiving Virtue: A Mengzian Adaptation Of Eudaimonic Virtue Ethics In Response To Contemporary Criticisms, Gina Elizabeth Lebkuecher

Dissertations

The primary question my dissertation aims to answer is: how might eudaimonic virtue ethics be reimagined to respond to contemporary criticisms from disability scholars, feminists, and empirical psychology? To answer this, I introduce the Eudaimonic View of Virtue, or EV, and propose a Mengzian adaptation of the EV (EV-M) in response to these criticisms. The EV captures the four core claims to which eudaimonic virtue ethical theories are committed: (i) virtues, in the sense of excellent character traits or dispositions, are the foundation of ethics or ethical action (i.e., aretaicism); (ii) virtue is at least partially constitutive of human well-being/flourishing …

The Osteological Neutral Pose Of The Neck Of An Apatosaurine Sauropod Based On Virtual And Physical Models, Colin Don Boisvert

Theses and Dissertations

An array of sauropod taxa coexisted in Late Jurassic North America. How so many giant genera coexisted without competing for food is puzzling considering their potential metabolic requirements. One aspect of this question is neck posture, which has been much contested, both in terms of the intrinsic curvature of the neck and the resultant elevation of the head. Neck curvature is characterized by the Osteological Neutral Pose (ONP), wherein the intervertebral joints are in an undeflected state. This pose is crucial to understanding neck posture. The articulated series of presacral vertebrae 2-19 of an exceptionally well-preserved apatosaurine, BYU 18531, are …

Sensory Asic3 Channel Exacerbates Psoriatic Inflammation Via A Neurogenic Pathway In Female Mice, Chen Huang, Pei-Yi Sun, Yiming Jiang, Yuandong Liu, Zhichao Liu, Shao-Ling Han, Bao-Shan Wang, Yong-Xin Huang, An-Ran Ren, Jian-Fei Lu, Qin Jiang, Ying Li, Michael X Zhu, Zhirong Yao, Yang Tian, Xin Qi, Wei-Guang Li, Tian-Le Xu

Faculty, Staff and Student Publications

Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerbates psoriatic inflammation through a sensory neurogenic pathway. Global or nociceptor-specific Asic3 knockout (KO) in female mice alleviates imiquimod-induced psoriatic acanthosis and type 17 inflammation to the same extent as nociceptor ablation. However, ASIC3 is dispensable for IL-23-induced psoriatic inflammation that bypasses the need for nociceptors. Mechanistically, ASIC3 activation induces the activity-dependent release of calcitonin gene-related peptide (CGRP) from sensory neurons to promote neurogenic inflammation. Botulinum neurotoxin A and CGRP antagonists prevent sensory neuron-mediated …

Understanding Enterprise Data Warehouses To Support Clinical And Translational Research: Impact, Sustainability, Demand Management, And Accessibility, Thomas R Campion, Catherine K Craven, David A Dorr, Elmer V Bernstam, Boyd M Knosp

Faculty, Staff and Student Publications

OBJECTIVES: Healthcare organizations, including Clinical and Translational Science Awards (CTSA) hubs funded by the National Institutes of Health, seek to enable secondary use of electronic health record (EHR) data through an enterprise data warehouse for research (EDW4R), but optimal approaches are unknown. In this qualitative study, our goal was to understand EDW4R impact, sustainability, demand management, and accessibility.

MATERIALS AND METHODS: We engaged a convenience sample of informatics leaders from CTSA hubs (n = 21) for semi-structured interviews and completed a directed content analysis of interview transcripts.

RESULTS: EDW4R have created institutional capacity for single- and multi-center studies, democratized access …

The Sound Of Silence: Listening For God In Cormac Mccarthy's The Road, Brittany Higgins Maloy

Theses and Dissertations

In the decimated and silent post-apocalyptic setting of Cormac McCarthy's The Road, the main characters spend a significant amount of time listening to silence, listening for signs of danger, but also listening for the voice of God. Many have discussed the hopeless nihilism juxtaposed with the heavy use of Christian iconography in the novel classifying it within one of these dichotomies or somewhere on the spectrum in between. This paper argues that the hopelessness and stark silence is required to reveal hope and the opportunity to hear God's voice. To demonstrate my argument, I define the characteristics of silence, stillness, …

Investigating The Intersections Of Vulnerability Detection And Iomts In Healthcare, A Scoping Review Protocol For Remote Patient Monitoring, Kulsoom S. Bughio, David M. Cook, Syed Afaq Shah

Research outputs 2022 to 2026

Due to the rapid and ubiquitous development and acceptance of IoT, healthcare providers have changed their locational settings from solely based in clinics to extend more broadly into the reach of patients’ domestic homes. This IoMT focus extends to various medical devices and applications within the healthcare domain, such as any form of smartphones, surveillance cameras, wearable sensors, and actuators, that hold the capability to access IoT technologies. The aim of this scoping review has two important objectives. The first is to understand the best approaches towards acquisition and refinement of data in favour of an optimised cyber security posture …

Epigenetic Regulation Of Skeletal Development, Austin Bell-Hensley

McKelvey School of Engineering Graduate Student Theses & Dissertations

Treatment of disorders that disrupt homeostasis of skeletal tissues, such as osteoarthritis, and developmental skeletal diseases, such as overgrowth syndromes, requires a precise understanding of skeletal development. Osteoarthritis is a whole joint disorder that can be caused by articular cartilage defects that illicit an inflammatory immune response. Articular cartilage does not have intrinsic processes for repair or regeneration, so it is necessary to develop tissue constructs to repair the native tissue. Since articular cartilage is not capable of repair, it is difficult to engraft cartilage tissue constructs. As such, it is necessary to develop a layered osteochondral construct that can …