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Communicating About A Nicotine Reduction Policy Among People Who Use Little Cigars And Cigarillos, Charity Afi Ntansah Jul 2024

Communicating About A Nicotine Reduction Policy Among People Who Use Little Cigars And Cigarillos, Charity Afi Ntansah

Theses and Dissertations

The U.S. Food and Drug Administration (FDA) has proposed rulemaking to reduce the nicotine content in cigarettes and other combusted tobacco products to non-addictive levels. A very low nicotine content (VLNC) policy aimed primarily at cigarettes could drive people to other combusted products like little cigars and cigarillos (LCCs), potentially undermining its effectiveness. Expanding the policy to include LCCs requires effective messages for people who use LCCs. This dissertation explores how to communicate the reduced nicotine policy to people who use LCCs. The research recruited four populations with the highest prevalence of cigar use: African American and White males and …


Enhancing The Security In High-Speed Networks Using P4 Programmable Switches, Ali Alsabeh Jul 2024

Enhancing The Security In High-Speed Networks Using P4 Programmable Switches, Ali Alsabeh

Theses and Dissertations

Network security has become increasingly essential in today's networks due to the growth of various network applications, such as Machine Learning (ML) and Fifth-Generation (5G) Networks. One fundamental Internet protocol is the Domain Name System (DNS), which maps domain names to Internet Protocol (IP) addresses. Despite its importance, DNS traffic is often forwarded without being analyzed, making it a center of ever-evolving attacks. Traditionally, defense strategies are implemented on fixed-function security middleboxes that are costly, proprietary, and hard to manage. Alternatively, defenses implemented in software use general-purpose servers (e.g., the control plane of a Software-Defined Networking (SDN) network) that cannot …


Neurocognitive Processes As Longitudinal Predictors Of Reading Fluency, Jody Samuels Jul 2024

Neurocognitive Processes As Longitudinal Predictors Of Reading Fluency, Jody Samuels

Theses and Dissertations

Reading fluency involves a complex interaction of different cognitive skills and abilities that develop with instruction and practice and relies on the automaticity of many distinct reading skills (e.g., pacing, word recognition, expression, phonological awareness). Fluent reading frees cognitive resources, such as working memory, for more advanced components of reading including comprehension and synthesis (Kim & Wagner, 2015; Samuels, 2006). Though early identification of students with fluency challenges is critical for providing evidence-based intervention, most screeners assess skills that are dependent upon instruction (e.g., letter identification, sound-symbol correspondence), delaying opportunities for identification. The current study examines the utility for including …


Fan, Friend, Or Foe: An Exploratory Scale Development Of Perception Of Social Media Influencers On Instagram, Katelynn Danyell Stewart Jul 2024

Fan, Friend, Or Foe: An Exploratory Scale Development Of Perception Of Social Media Influencers On Instagram, Katelynn Danyell Stewart

Theses and Dissertations

This study aims to start the scale-building process of perception of social media influencers. This dissertation analyzes lifestyle Instagram influencers' followers’ perceptions of the influencer, their brand, and their communication and interaction efforts with followers through Instagram. This survey will help test the independent variables and dependent variables through the public relations lens using a combination of parasocial relationship theory, source credibility theory, and uses and gratifications theory to determine the effects and behaviors that lifestyle Instagram influencers have on their followers connected to influencer brand and influencer interactivity; and how lifestyle Instagram influencer usage, influencer authenticity, and parasocial relation …


Measuring Evidence Application In Routine Mental Health Settings: Testing A Coding System And Providing A Proof Of Concept, Eleanor Wu Jul 2024

Measuring Evidence Application In Routine Mental Health Settings: Testing A Coding System And Providing A Proof Of Concept, Eleanor Wu

Theses and Dissertations

Over the past 25 years, there have been increasing calls to advance the application of evidence in routine mental health settings for youth and families. Methods in the field for characterizing evidence application have played a critical role in shaping these efforts, which, to-date, have largely focused on measuring providers’ adherence to practices from evidence-based programs in treatment sessions. While this program-centric paradigm for characterizing evidence application has supported the widespread implementation of evidence-based programs in public mental health settings, it is limited in scope and applicability for characterizing all the ways that evidence may be applied across a service …


Essays In Labor Economics, Inclusion, And Diversity, Saharnaz Babaei Balderlou Jul 2024

Essays In Labor Economics, Inclusion, And Diversity, Saharnaz Babaei Balderlou

Theses and Dissertations

This dissertation presents a comprehensive analysis of various teacher staffing policies and their impact on teacher retention and turnover. It comprises three studies, each addressing a unique aspect of teacher staffing challenges in the United States and in South Carolina. Chapter 2 investigates how different salary structures (frontloading vs. backloading) affect teacher turnover in South Carolina. Using a Difference-in-Differences (DID) approach and data from FY2014 to FY2023, the study finds that frontloading salary schedules do not significantly impact overall teacher turnover, with negligible effects on novice teachers. However, the impact varies with district characteristics: specifically, frontloading may reduce turnover in …


Offshore Detachment Of The Winyah Bay Plume Through Ekman Dynamics Under Upwelling Conditions, Isabella Moore Jul 2024

Offshore Detachment Of The Winyah Bay Plume Through Ekman Dynamics Under Upwelling Conditions, Isabella Moore

Theses and Dissertations

ABSTRACT River plumes play a crucial role in coastal ecosystems by influencing land-ocean interactions, primary production, water quality, and ocean circulation. This study presents observations of a buoyant river plume off Winyah Bay, South Carolina (USA), conducted in 2020 and 2021. Observations comprised CTD casts and shipborne ADCP profiles as well as near surface flow measurements from a floating platform and microstructure profiles in uprising mode. This research focuses on the offshore transport of the buoyant water through Ekman dynamics under upwelling-favorable conditions. Under varying wind forcing and stratification scenarios, the Winyah Bay plume either remains near the coast or …


Multi-Scale Deep Representation Learning In Synthetic Biology, Xiaoyi Liu Jul 2024

Multi-Scale Deep Representation Learning In Synthetic Biology, Xiaoyi Liu

Theses and Dissertations

Synthetic biology advances and combines the expertise of engineers and biologists, bridging the gap between engineering and natural life. Synthetic biology has been generally categorized into two broad branches by developing new biological components, networks, and systems to reprogram organisms. The first branch involves using synthetic molecules to mimic natural biological functions. The second branch focuses on assembling natural biological components in novel ways, aiming to produce systems with unique, practical functions. Thus, the de novo engineering of biological modules and synthetic pathways is used in related practical bioengineering applications, such as drug-targeting strategies and microbial product manufacturing. Therefore, synthetic …


Improving Distributed Health Information Technology Integration Through Enriched Context In Sociotechnical System Components, Jeritt Thayer Jul 2024

Improving Distributed Health Information Technology Integration Through Enriched Context In Sociotechnical System Components, Jeritt Thayer

Dissertations and Theses (Open Access)

The design and architecture of health information technology (HIT) are in the process of a transformative shift. Monolithic code bases, which are several systems intertwined into a single program, are being split into multiple distributed programs that communicate across information networks. Thus far, only sparse knowledge exists about the challenges of distributed HIT, and the interaction of these architectures with other factors of the sociotechnical system, such as clinical content, is not well understood. Existing sociotechnical models describe the components within a healthcare system and the connections between components, but the types of relationships between each component are underspecified. Within …


Chatgpt In The Classroom: A Practical Guide For Educators, Sang-A Lee, Jacob Welch, Ryan J. Wallace, David Cross, Jon M. Loffi Jul 2024

Chatgpt In The Classroom: A Practical Guide For Educators, Sang-A Lee, Jacob Welch, Ryan J. Wallace, David Cross, Jon M. Loffi

Journal of Aviation/Aerospace Education & Research

This paper explores the potential applications of ChatGPT, a powerful Artificial Intelligence (AI) large language model (LLM) developed by OpenAI, for aviation education applications. The authors provide an overview of ChatGPT and its unique features, such as accessibility, conversational abilities, and personalized learning capabilities. The scalability of ChatGPT allows individualized and personalized instruction, a revolutionary aspect that can potentially enhance the student learning experience. This applied research employed an exploratory design to investigate ChatGPT's potential applications to enhance learning at varied levels of learning. The study investigated four research questions: (1) How can ChatGPT be used by students to support …


Mandatory Mediation In England And Wales: A Paradigm Shift In Dispute Resolution, Mckayla Bogda Jul 2024

Mandatory Mediation In England And Wales: A Paradigm Shift In Dispute Resolution, Mckayla Bogda

Journal of Dispute Resolution

In May of 2023, Tribunals in England and Wales had a backlog of nearly 144,000 cases. In a press release issued on July 25, 2023, the Ministry of Justice (MoJ) unveiled a significant policy change to combat this backlog. Under its new directive, individuals or entities wishing to pursue debt recovery claims of £10,000 or less are required to engage in mediation proceedings prior to their case’s adjudication in the small claims courts of England and Wales. This transformative shift signifies a departure from the traditional adversarial litigation model of both of these countries’ judicial systems.


Functional Multivariable Logistic Regression With An Application To Hiv Viral Suppression Prediction, Siyuan Guo, Jiajia Zhang Ph.D., Yichao Wu, Alexander C. Mclain Ph.D., James W. Hardin, Bankole Olatosi Ph.D., Xiaoming Li Ph.D. Jul 2024

Functional Multivariable Logistic Regression With An Application To Hiv Viral Suppression Prediction, Siyuan Guo, Jiajia Zhang Ph.D., Yichao Wu, Alexander C. Mclain Ph.D., James W. Hardin, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Motivated by improving the prediction of the human immunodeficiency virus (HIV) suppression status using electronic health records (EHR) data, we propose a functional multivariable logistic regression model, which accounts for the longitudinal binary process and continuous process simultaneously. Specifically, the longitudinal measurements for either binary or continuous variables are modeled by functional principal components analysis, and their corresponding functional principal component scores are used to build a logistic regression model for prediction. The longitudinal binary data are linked to underlying Gaussian processes. The estimation is done using penalized spline for the longitudinal continuous and binary data. Group-lasso is used to …


Let’S Speak Chinese! 我们来讲中文!4th Edition, Jasmine Kong-Yan Tang Jul 2024

Let’S Speak Chinese! 我们来讲中文!4th Edition, Jasmine Kong-Yan Tang

Geneseo Authors

This book is for those with experience learning Mandarin but who need confidence interacting in everyday situations. What distinguishes Let’s Speak Chinese! from other language acquisition guides is the emphasis on practical usage and the promotion of self-learning. There are eight chapters based on common themes, each illustrating typical dialogue: Shopping, Food & Drink, Asking for Help, Personal Information & Daily Conversation, Family & Relationships, Travel, In the Classroom, and Time & Seasons. This latest edition features more activities and resources. Now, dive in! The Traditional Characters edition can be purchased here.


Association Of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma And Skin Carotenoid Concentrations In Adults Provided A Lycopene-Rich Juice, Anna C Norman, Daniel G Palmer, Nancy E Moran, James N Roemmich, Shanon L Casperson Jul 2024

Association Of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma And Skin Carotenoid Concentrations In Adults Provided A Lycopene-Rich Juice, Anna C Norman, Daniel G Palmer, Nancy E Moran, James N Roemmich, Shanon L Casperson

Children’s Nutrition Research Center Staff Publications

Background: Carotenoids are fat-soluble phytochemicals with biological roles, including ultraviolet protective functions in skin. Spectroscopic skin carotenoid measurements can also serve as a noninvasive biomarker for carotenoid consumption. Single-nucleotide polymorphisms (SNPs) in metabolic genes are associated with human plasma carotenoid concentrations; however, their relationships with skin carotenoid concentrations are unknown.

Objectives: The objective of this study was to determine the relationship between 13 candidate SNPs with skin and plasma carotenoid concentrations before and after a carotenoid-rich tomato juice intervention.

Methods: In this randomized, controlled trial, participants (n = 80) were provided with lycopene-rich vegetable juice providing low (13.1 mg), medium …


The Role Of Executive Function In Cognitive Reappraisal: A Meta-Analytic Review, Wei Xing Toh, Jun Sheng Keh, James J. Gross, Laura L. Carstensen Jul 2024

The Role Of Executive Function In Cognitive Reappraisal: A Meta-Analytic Review, Wei Xing Toh, Jun Sheng Keh, James J. Gross, Laura L. Carstensen

Research Collection School of Social Sciences

Cognitive reappraisal refers to the reinterpretation of a situation to alter its emotional meaning. Theoretically, executive functions (EFs), such as inhibition, updating, and shifting, are core elements of reappraisal processes. However, empirical studies have yielded inconsistent evidence as to whether and to what extent EFs are associated with reappraisal. To address this issue, we conducted a meta-analysis of the literature in which 179 effect sizes from 59 independent samples (N = 4,703) were included. Using random-effects metaregression with robust-variance estimates and small-sample corrections, we also examined whether variation in effect sizes could be accounted for by potential moderators, such as …


Attribute-Based Fine-Grained Access Control Using Verifiable Credentials, Srinivasa Dumpa Jul 2024

Attribute-Based Fine-Grained Access Control Using Verifiable Credentials, Srinivasa Dumpa

Student Theses

In the era of digital transformation, ensuring secure and privacy-preserving access control mechanisms is of paramount importance. Traditional identity-based access control systems often fall short in providing granular control and user autonomy over digital identities. This thesis presents a novel approach to access control by leveraging the power of verifiable credentials and attribute-based access control. The proposed system introduces a decentralized and user-centric framework that enables fine-grained access control based on specific attributes encapsulated within verifiable credentials. These tamper-evident digital credentials, stored in a user's digital wallet, contain a rich set of attributes that can be selectively disclosed to grant …


Understanding The Genetic Complexity Of Puberty Timing Across The Allele Frequency Spectrum, Katherine A Kentistou, Lena R Kaisinger, Stasa Stankovic, Marc Vaudel, Edson Mendes De Oliveira, Andrea Messina, Robin G Walters, Xiaoxi Liu, Alexander S Busch, Hannes Helgason, Deborah J Thompson, Federico Santoni, Konstantin M Petricek, Yassine Zouaghi, Isabel Huang-Doran, Daniel F Gudbjartsson, Eirik Bratland, Kuang Lin, Eugene J Gardner, Yajie Zhao, Raina Y Jia, Chikashi Terao, Marjorie J Riggan, Manjeet K Bolla, Mojgan Yazdanpanah, Nahid Yazdanpanah, Jonathan P Bradfield, Linda Broer, Archie Campbell, Daniel I Chasman, Diana L Cousminer, Nora Franceschini, Lude H Franke, Giorgia Girotto, Chunyan He, Marjo-Riitta Järvelin, Peter K Joshi, Yoichiro Kamatani, Robert Karlsson, Jian'an Luan, Kathryn L Lunetta, Reedik Mägi, Massimo Mangino, Sarah E Medland, Christa Meisinger, Raymond Noordam, Teresa Nutile, Maria Pina Concas, Ozren Polašek, Eleonora Porcu, Susan M Ring, Cinzia Sala, Albert V Smith, Toshiko Tanaka, Peter J Van Der Most, Veronique Vitart, Carol A Wang, Gonneke Willemsen, Marek Zygmunt, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Paul L Auer, Catriona L K Barnes, Matthias W Beckmann, Amy Berrington De Gonzalez, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Julie E Buring, Federico Canzian, Jenny Chang-Claude, Fergus J Couch, Angela Cox, Laura Crisponi, Kamila Czene, Mary B Daly, Ellen W Demerath, Joe Dennis, Peter Devilee, Immaculata De Vivo, Thilo Dörk, Alison M Dunning, Miriam Dwek, Johan G Eriksson, Peter A Fasching, Lindsay Fernandez-Rhodes, Liana Ferreli, Olivia Fletcher, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Anna González-Neira, Harald Grallert, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Hakon Hakonarson, Roger J Hart, Martha Hickey, Maartje J Hooning, Reiner Hoppe, John L Hopper, Jouke-Jan Hottenga, Frank B Hu, Hanna Huebner, David J Hunter, Helena Jernström, Esther M John, David Karasik, Elza K Khusnutdinova, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Lenore J Launer, Penelope A Lind, Annika Lindblom, Patrik K E Magnusson, Arto Mannermaa, Mark I Mccarthy, Thomas Meitinger, Cristina Menni, Kyriaki Michailidou, Iona Y Millwood, Roger L Milne, Grant W Montgomery, Heli Nevanlinna, Ilja M Nolte, Dale R Nyholt, Nadia Obi, Katie M O'Brien, Kenneth Offit, Albertine J Oldehinkel, Sisse R Ostrowski, Aarno Palotie, Ole B Pedersen, Annette Peters, Giulia Pianigiani, Dijana Plaseska-Karanfilska, Anneli Pouta, Alfred Pozarickij, Paolo Radice, Gad Rennert, Frits R Rosendaal, Daniela Ruggiero, Emmanouil Saloustros, Dale P Sandler, Sabine Schipf, Carsten O Schmidt, Marjanka K Schmidt, Kerrin Small, Beatrice Spedicati, Meir Stampfer, Jennifer Stone, Rulla M Tamimi, Lauren R Teras, Emmi Tikkanen, Constance Turman, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Babette S Zemel, Wei Zheng, Ko W Van Dijk, Behrooz Z Alizadeh, Stefania Bandinelli, Eric Boerwinkle, Dorret I Boomsma, Marina Ciullo, Georgia Chenevix-Trench, Francesco Cucca, Tõnu Esko, Christian Gieger, Struan F A Grant, Vilmundur Gudnason, Caroline Hayward, Ivana Kolčić, Peter Kraft, Deborah A Lawlor, Nicholas G Martin, Ellen A Nøhr, Nancy L Pedersen, Craig E Pennell, Paul M Ridker, Antonietta Robino, Harold Snieder, Ulla Sovio, Tim D Spector, Doris Stöckl, Cathie Sudlow, Nic J Timpson, Daniela Toniolo, André Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J Wareham, Elisabeth Widen, James F Wilson, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Paul D P Pharoah, Liming Li, Douglas F Easton, Pål R Njølstad, Patrick Sulem, Joanne M Murabito, Anna Murray, Despoina Manousaki, Anders Juul, Christian Erikstrup, Kari Stefansson, Momoko Horikoshi, Zhengming Chen, I Sadaf Farooqi, Nelly Pitteloud, Stefan Johansson, Felix R Day, John R B Perry, Ken K Ong Jul 2024

Understanding The Genetic Complexity Of Puberty Timing Across The Allele Frequency Spectrum, Katherine A Kentistou, Lena R Kaisinger, Stasa Stankovic, Marc Vaudel, Edson Mendes De Oliveira, Andrea Messina, Robin G Walters, Xiaoxi Liu, Alexander S Busch, Hannes Helgason, Deborah J Thompson, Federico Santoni, Konstantin M Petricek, Yassine Zouaghi, Isabel Huang-Doran, Daniel F Gudbjartsson, Eirik Bratland, Kuang Lin, Eugene J Gardner, Yajie Zhao, Raina Y Jia, Chikashi Terao, Marjorie J Riggan, Manjeet K Bolla, Mojgan Yazdanpanah, Nahid Yazdanpanah, Jonathan P Bradfield, Linda Broer, Archie Campbell, Daniel I Chasman, Diana L Cousminer, Nora Franceschini, Lude H Franke, Giorgia Girotto, Chunyan He, Marjo-Riitta Järvelin, Peter K Joshi, Yoichiro Kamatani, Robert Karlsson, Jian'an Luan, Kathryn L Lunetta, Reedik Mägi, Massimo Mangino, Sarah E Medland, Christa Meisinger, Raymond Noordam, Teresa Nutile, Maria Pina Concas, Ozren Polašek, Eleonora Porcu, Susan M Ring, Cinzia Sala, Albert V Smith, Toshiko Tanaka, Peter J Van Der Most, Veronique Vitart, Carol A Wang, Gonneke Willemsen, Marek Zygmunt, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Paul L Auer, Catriona L K Barnes, Matthias W Beckmann, Amy Berrington De Gonzalez, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Julie E Buring, Federico Canzian, Jenny Chang-Claude, Fergus J Couch, Angela Cox, Laura Crisponi, Kamila Czene, Mary B Daly, Ellen W Demerath, Joe Dennis, Peter Devilee, Immaculata De Vivo, Thilo Dörk, Alison M Dunning, Miriam Dwek, Johan G Eriksson, Peter A Fasching, Lindsay Fernandez-Rhodes, Liana Ferreli, Olivia Fletcher, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Anna González-Neira, Harald Grallert, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Hakon Hakonarson, Roger J Hart, Martha Hickey, Maartje J Hooning, Reiner Hoppe, John L Hopper, Jouke-Jan Hottenga, Frank B Hu, Hanna Huebner, David J Hunter, Helena Jernström, Esther M John, David Karasik, Elza K Khusnutdinova, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Lenore J Launer, Penelope A Lind, Annika Lindblom, Patrik K E Magnusson, Arto Mannermaa, Mark I Mccarthy, Thomas Meitinger, Cristina Menni, Kyriaki Michailidou, Iona Y Millwood, Roger L Milne, Grant W Montgomery, Heli Nevanlinna, Ilja M Nolte, Dale R Nyholt, Nadia Obi, Katie M O'Brien, Kenneth Offit, Albertine J Oldehinkel, Sisse R Ostrowski, Aarno Palotie, Ole B Pedersen, Annette Peters, Giulia Pianigiani, Dijana Plaseska-Karanfilska, Anneli Pouta, Alfred Pozarickij, Paolo Radice, Gad Rennert, Frits R Rosendaal, Daniela Ruggiero, Emmanouil Saloustros, Dale P Sandler, Sabine Schipf, Carsten O Schmidt, Marjanka K Schmidt, Kerrin Small, Beatrice Spedicati, Meir Stampfer, Jennifer Stone, Rulla M Tamimi, Lauren R Teras, Emmi Tikkanen, Constance Turman, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Babette S Zemel, Wei Zheng, Ko W Van Dijk, Behrooz Z Alizadeh, Stefania Bandinelli, Eric Boerwinkle, Dorret I Boomsma, Marina Ciullo, Georgia Chenevix-Trench, Francesco Cucca, Tõnu Esko, Christian Gieger, Struan F A Grant, Vilmundur Gudnason, Caroline Hayward, Ivana Kolčić, Peter Kraft, Deborah A Lawlor, Nicholas G Martin, Ellen A Nøhr, Nancy L Pedersen, Craig E Pennell, Paul M Ridker, Antonietta Robino, Harold Snieder, Ulla Sovio, Tim D Spector, Doris Stöckl, Cathie Sudlow, Nic J Timpson, Daniela Toniolo, André Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J Wareham, Elisabeth Widen, James F Wilson, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Paul D P Pharoah, Liming Li, Douglas F Easton, Pål R Njølstad, Patrick Sulem, Joanne M Murabito, Anna Murray, Despoina Manousaki, Anders Juul, Christian Erikstrup, Kari Stefansson, Momoko Horikoshi, Zhengming Chen, I Sadaf Farooqi, Nelly Pitteloud, Stefan Johansson, Felix R Day, John R B Perry, Ken K Ong

Faculty, Staff and Student Publications

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, …


High Throughput Plasma Proteomics And Risk Of Heart Failure And Frailty In Late Life, Diego Ramonfaur, Leo F Buckley, Victoria Arthur, Yimin Yang, Brian L Claggett, Chiadi E Ndumele, Keenan A Walker, Thomas Austin, Michelle C Odden, James S Floyd, Sandra Sanders-Van Wijk, Joyce Njoroge, Jorge R Kizer, Dalane Kitzman, Suma H Konety, Jennifer Schrack, Fangyu Liu, B Gwen Windham, Priya Palta, Josef Coresh, Bing Yu, Amil M Shah Jul 2024

High Throughput Plasma Proteomics And Risk Of Heart Failure And Frailty In Late Life, Diego Ramonfaur, Leo F Buckley, Victoria Arthur, Yimin Yang, Brian L Claggett, Chiadi E Ndumele, Keenan A Walker, Thomas Austin, Michelle C Odden, James S Floyd, Sandra Sanders-Van Wijk, Joyce Njoroge, Jorge R Kizer, Dalane Kitzman, Suma H Konety, Jennifer Schrack, Fangyu Liu, B Gwen Windham, Priya Palta, Josef Coresh, Bing Yu, Amil M Shah

Faculty, Staff and Student Publications

Importance: Heart failure (HF) and frailty frequently coexist and may share a common pathobiology, although the underlying mechanisms remain unclear. Understanding these mechanisms may provide guidance for preventing and treating both conditions.

Objective: To identify shared pathways between incident HF and frailty in late life using large-scale proteomics.

Design, setting, and participants: In this cohort study, 4877 aptamers (Somascan v4) were measured among participants in the community-based longitudinal Atherosclerosis Risk In Communities (ARIC) cohort study at visit 3 (V3; 1993-1995; n = 10 638) and at visit 5 (V5; 2011-2013; n = 3908). Analyses were externally replicated among 3189 participants …


The Impact Of Ribosome Biogenesis In Cancer: From Proliferation To Metastasis, Nitish Mittal, Faisal S Ali, Antonio Pizuorno Machado, Sean Ngo, Malek Shatila, Tomas Davee, Nirav Thosani, Vaibhav Wadhwa Jul 2024

The Impact Of Ribosome Biogenesis In Cancer: From Proliferation To Metastasis, Nitish Mittal, Faisal S Ali, Antonio Pizuorno Machado, Sean Ngo, Malek Shatila, Tomas Davee, Nirav Thosani, Vaibhav Wadhwa

Faculty, Staff and Student Publications

A proportion of patients who undergo intraoperative cholangiogram (IOC) do not have bile duct stones at the time of endoscopic retrograde cholangiopancreatography (ERCP), either due to the spontaneous passage of stones or a false-positive IOC. Glucagon has been utilized as an inexpensive tool to allow the passage of micro-choledocholithiasis to the duodenum and resolve filling defects caused by stones or air bubbles. The purpose of our study is to understand the change in diagnostic accuracy of IOC to detect choledocholithiasis with intraoperative glucagon. We conducted a retrospective study at a tertiary care center on adult patients who underwent laparoscopic cholecystectomy …


Personal Light Exposure Patterns And Incidence Of Type 2 Diabetes: Analysis Of 13 Million Hours Of Light Sensor Data And 670,000 Person-Years Of Prospective Observation, Daniel P Windred, Angus C Burns, Martin K Rutter, Chris Ho Ching Yeung, Jacqueline M Lane, Qian Xiao, Richa Saxena, Sean W Cain, Andrew J K Phillips Jul 2024

Personal Light Exposure Patterns And Incidence Of Type 2 Diabetes: Analysis Of 13 Million Hours Of Light Sensor Data And 670,000 Person-Years Of Prospective Observation, Daniel P Windred, Angus C Burns, Martin K Rutter, Chris Ho Ching Yeung, Jacqueline M Lane, Qian Xiao, Richa Saxena, Sean W Cain, Andrew J K Phillips

Faculty, Staff and Student Publications

BACKGROUND: Light at night disrupts circadian rhythms, and circadian disruption is a risk factor for type 2 diabetes. Whether personal light exposure predicts diabetes risk has not been demonstrated in a large prospective cohort. We therefore assessed whether personal light exposure patterns predicted risk of incident type 2 diabetes in UK Biobank participants, using ∼13 million hours of light sensor data.

METHODS: Participants (N = 84,790, age (M ± SD) = 62.3 ± 7.9 years, 58% female) wore light sensors for one week, recording day and night light exposure. Circadian amplitude and phase were modeled from weekly light data. Incident …


Transgender Women With Suppressed Testosterone Display Lower Burden Of Coronary Disease Than Matched Cisgender Men, Jordan E Lake, Han Feng, Ana N Hyatt, Hongyu Miao, Paula Debroy, Nicholas Funderburg, Kate Ailstock, Adrian Dobs, Sabina Haberlen, Jared W Magnani, Joseph B Margolick, Kate Mcgowan, Frank J Palella, Mallory D Witt, Shalender Bhasin, Matthew J Budoff, Wendy S Post, Todd T Brown Jul 2024

Transgender Women With Suppressed Testosterone Display Lower Burden Of Coronary Disease Than Matched Cisgender Men, Jordan E Lake, Han Feng, Ana N Hyatt, Hongyu Miao, Paula Debroy, Nicholas Funderburg, Kate Ailstock, Adrian Dobs, Sabina Haberlen, Jared W Magnani, Joseph B Margolick, Kate Mcgowan, Frank J Palella, Mallory D Witt, Shalender Bhasin, Matthew J Budoff, Wendy S Post, Todd T Brown

Faculty, Staff and Student Publications

Context: Cardiovascular disease (CVD) in transgender women (TW) may be affected by gender-affirming hormone therapy (GAHT) and HIV, but few data compare TW on contemporary GAHT to well-matched controls.

Objective: We compared CVD burden and biomarker profiles between TW and matched cisgender men (CM).

Methods: Adult TW on GAHT (n = 29) were recruited for a cross-sectional study (2018-2020). CM (n = 48) from the former Multicenter AIDS Cohort Study were matched 2:1 to TW on HIV serostatus, age ±5 years, race/ethnicity, BMI category and antiretroviral therapy (ART) type. Cardiac parameters were measured by CT and coronary atherosclerosis by coronary …


Long-Term Immune Response To Sars-Cov-2 Infection And Vaccination In Children And Adolescents, Sarah E Messiah, Yashar Talebi, Michael D Swartz, Rachit Sabharwal, Haoting Han, Emma Bergqvist, Harold W Kohl, Melissa Valerio-Shewmaker, Stacia M Desantis, Ashraf Yaseen, Steven H Kelder, Jessica Ross, Lindsay N Padilla, Michael O Gonzalez, Leqing Wu, David Lakey, Jennifer A Shuford, Stephen J Pont, Eric Boerwinkle Jul 2024

Long-Term Immune Response To Sars-Cov-2 Infection And Vaccination In Children And Adolescents, Sarah E Messiah, Yashar Talebi, Michael D Swartz, Rachit Sabharwal, Haoting Han, Emma Bergqvist, Harold W Kohl, Melissa Valerio-Shewmaker, Stacia M Desantis, Ashraf Yaseen, Steven H Kelder, Jessica Ross, Lindsay N Padilla, Michael O Gonzalez, Leqing Wu, David Lakey, Jennifer A Shuford, Stephen J Pont, Eric Boerwinkle

Faculty, Staff and Student Publications

BACKGROUND: This analysis examined the durability of antibodies present after SARS-CoV-2 infection and vaccination in children and adolescents.

METHODS: Data were collected over 4 time points between October 2020-November 2022 as part of a prospective population-based cohort aged 5-to-19 years (N = 810). Results of the (1) Roche Elecsys® Anti-SARS-CoV-2 Immunoassay for detection of antibodies to the SARS-CoV-2 nucleocapsid protein (Roche N-test); and (2) qualitative and semi-quantitative detection of antibodies to the SARS CoV-2 spike protein receptor binding domain (Roche S-test); and (3) self-reported antigen/PCR COVID-19 test results, vaccination and symptom status were analyzed.

RESULTS: N antibody levels reached a …


The Needless Search For A Founding-Era "Hearsay" Definition, Jeffrey Bellin Jul 2024

The Needless Search For A Founding-Era "Hearsay" Definition, Jeffrey Bellin

Vanderbilt Law School Faculty Publications

Modern Confrontation Clause doctrine permits only unconfronted "out-of-court statements that would have been admissible in a criminal case at the time of the founding." To operationalize this concept, the Supreme Court identifies "testimonial hearsay" as the Clause's primary concern. Its opinions regularly dive into the historical record to refine what counts as "testimonial" but ignore that record in defining "hearsay." This omission cannot last. Cases in the lower courts, and one on the Court's recent docket, concern testimonial but (arguably) non-hearsay statements. And while confrontation jurisprudence is supposed to be tied to founding-era evidence law, the "hearsay" definition, casually referenced …


A "Profoundly Contractarian Predisposition": Delaware Courts Decide Recent Drafting Disputes By Limiting Their Review To Four Corners Of Contracts, Robert S. Reder, Kathleen E. Sharkey Jul 2024

A "Profoundly Contractarian Predisposition": Delaware Courts Decide Recent Drafting Disputes By Limiting Their Review To Four Corners Of Contracts, Robert S. Reder, Kathleen E. Sharkey

Vanderbilt Law School Faculty Publications

In the decisions discussed herein, both the Delaware Supreme Court ("Supreme Court") and the Delaware Court of Chancery ("Chancery Court") reaffirmed the Delaware judiciary's commitment to honoring contract language, whenever possible, to settle contractual disputes. Absent irreconcilable ambiguity, no coloring outside the lines will be considered. The goal generally is to reflect the intent of the parties while avoiding absurd or illogical results. Ironically, in each of these cases, better drafting could have ensured the parties were on the same page: " In Arwood v. AW Site Services, Vice Chancellor Slights, confirming Delaware's status as "'more contractarian' than most states," …


The Effects Of Relational Human Resource Management: A Moderated Mediation Model Of Positive Affective Climate And Collective Occupational Calling, Pingshu Li, Yuanmei (Elly) Qu, Mengwei Li, Patrick E. Downes, Guofeng Wang Jul 2024

The Effects Of Relational Human Resource Management: A Moderated Mediation Model Of Positive Affective Climate And Collective Occupational Calling, Pingshu Li, Yuanmei (Elly) Qu, Mengwei Li, Patrick E. Downes, Guofeng Wang

Management Faculty Publications

Relationship-oriented human resource management (HRM) contributes to organizational functioning by promoting employee relationships, coordination, and cooperation. We propose unit-level positive affective climate as a motivational mechanism through which relationship-oriented HR systems can positively influence unit service quality and relationships with beneficiaries, and prevent individual emotional exhaustion. Moreover, we propose collective occupational calling serves as an alternative motivational source that can substitute for the positive effects of positive affective climate. In analyzing a sample composed of 742 nurses from 48 nursing units of two hospitals in China with data collection at three time points before and after the COVID-19 outbreak, our …


Activity And Assignment - Imagine Your Democracy— Creative Writing Responses, Daneen Bergland Jul 2024

Activity And Assignment - Imagine Your Democracy— Creative Writing Responses, Daneen Bergland

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.


Student Development (Sdv) Module - Civic Engagement And Learning For Democracy, Russ Wood Jul 2024

Student Development (Sdv) Module - Civic Engagement And Learning For Democracy, Russ Wood

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.


Course Syllabus - Key Issues In State And Federal Constitutional Government, Megan Vangorder Jul 2024

Course Syllabus - Key Issues In State And Federal Constitutional Government, Megan Vangorder

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.


Classroom Activity Or Homework Assignment - Federalism Flares: Connecting Civic Concepts To Current Eve, Megan Vangorder Jul 2024

Classroom Activity Or Homework Assignment - Federalism Flares: Connecting Civic Concepts To Current Eve, Megan Vangorder

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.


Course Syllabus - American Democracy A Draft Syllabus Outline For A University-Level, Advanced Undergraduate Course, Michael Landis Jul 2024

Course Syllabus - American Democracy A Draft Syllabus Outline For A University-Level, Advanced Undergraduate Course, Michael Landis

Civic Engagement & Voting Rights Teacher Scholars

No abstract provided.