Digital Commons Network^™

Conserved Mechanisms Of Drug Induced Lifespan Extension In S. Cerevisiae And C. Elegans, Christine E. Robbins

Biomedical Sciences ETDs

Aging is a phenomenon that brings aches, pains and a risk of developing diseases. Many researchers have discovered pathways that regulate aging by altering gene expression. Understanding genetic regulation of aging is key but identifying drugs that target aging will result in translatable treatments. Additionally, understanding how drugs are interacting with our cells allows us to create targeted therapies. I study two types of drugs. First, tRNA synthetase inhibitors are a class of drugs that inhibit charging of tRNAs. I identified a mechanism of lifespan extension by upregulation of the conserved transcription factor, Gcn4 / Atf-4. Second, I found that …

Teaching Adults With Developmental Disabilities To Ask "Why?", Mya White

Theses

Mands for information play an important role in language development and are important for successfully acquiring new information from one’s environment. Still, many individuals cannot effectively ask Wh- questions to mand for information, even though they may have extensive tact, intraverbal, and receptive language skills. Recently, Valentino et al. (2019) investigated procedures to teach the MFI “Why?” to children with language delays under the control of the establishing operation and examined the extent to which teaching resulted in generalization. The purpose of this study was to extend Valentino et al. protocol with three adults with developmental disabilities. The procedure involved …

Toward The Development Of A Pan-Lyssavirus Vaccine, Sabrine Ben Hamed, Jacob Myers, Anisha Chandwani, Christoph Wirblich, Drishya Kurup, Nir Paran, Matthias Schnell

Department of Microbiology and Immunology Faculty Papers

In addition to the rabies virus (RABV), 16 more lyssavirus species have been identified worldwide, causing a disease similar to RABV. Non-rabies-related human deaths have been described, but the number of cases is unknown, and the potential of such lyssaviruses causing human disease is unpredictable. The current rabies vaccine does not protect against divergent lyssaviruses such as Mokola virus (MOKV) or Lagos bat virus (LBV). Thus, a more broad pan-lyssavirus vaccine is needed. Here, we evaluate a novel lyssavirus vaccine with an attenuated RABV vector harboring a chimeric RABV glycoprotein (G) in which the antigenic site I of MOKV replaces …

Adaptive Screen Capture Video Analysis, Ugesh Egala

Electrical and Computer Engineering ETDs

This thesis presents a system for analyzing student activities during class sessions to gain insights into the learning process. A dataset consisting of 14 screen recordings, with 2 videos labeled across two stages, was used for training, validation, and testing. The methodology employs adaptive sampling, initially at 10 frames per minute to identify active regions, followed by detailed analysis at 1 frame per second using OCR to detect typing activities through character changes. The results demonstrate over a 50% reduction in computational load while maintaining high accuracy in detecting student engagement. A total of 26 hours of screen capture videos …

Costs And Impact Of Disease In Adults With Sickle Cell Disease: A Pilot Study, Sophie Lanzkron, Nicole Crook, Joanne Wu, Sarah Hussain, Randall G. Curtis, Derek Robertson, Judith R. Baker, Diane Nugent, Amit Soni, Jonathan C. Roberts, Megan M. Ullman, Julie Kanter, Michael B. Nichol

Cardeza Foundation for Hematologic Research

We assessed the feasibility to estimate illness burden in adults with SCD, investigated factors associated with health-related quality of life (HRQoL), and estimated societal burden. We recruited 32 participants and collected data on fatigue, HRQoL, and work productivity and activity impairment via patient survey. Health care utilization was abstracted for the 12 months before enrollment using medical chart review. Mean age was 36.7 years; 84.4% of participants had hemoglobin SS or Sβthal0 disease, and 81.3% reported chronic pain (experiencing pain on ≥3 days per week in the past 6 months). Mean EQ-5D-3L visual analogue scale score was 63.4 and the …

Pafundi, Barbara, Sophia Maier Garcia

Bronx Jewish History Project

Summarizer: Sophia Maier

Barbara Pafundi, born 1952, grew up in Parkchester in the East Bronx. Her grandparents immigrated from Ukraine and Romania, and her father was born in Charleston, South Carolina. Pafundi describes Parkchester as primarily Jewish and Irish and a really beautiful place to grow up, with green areas around the apartment buildings. She would go with her family to the local Chinese restaurant, grocery stores, and library. Reading is a continued love. In the summers, they would go up to Putnam Valley.

Pafundi explains they never felt antisemitism, except she is not sure if St Helena’s would purposefully …

Discordant Prenatal Cell-Free Dna Screening Vs. Diagnostic Results Of Sex Chromosome Aneuploidies: Implications For Newborn Screening And Genetic Counseling, Susan Howell, Shanlee M. Davis, Billie Carstens, Mary Haag, Judith L. Ross, Nicole R. Tartaglia

Department of Pediatrics Faculty Papers

Sex chromosome aneuploidies (SCAs) collectively occur in 1 in 500 livebirths, and diagnoses in the neonatal period are increasing with advancements in prenatal and early genetic testing. Inevitably, SCA will be identified on either routine prenatal or newborn screening in the near future. Tetrasomy SCAs are rare, manifesting more significant phenotypes compared to trisomies. Prenatal cell-free DNA (cfDNA) screening has been demonstrated to have relatively poor positive predictive values (PPV) in SCAs, directing genetic counseling discussions towards false-positive likelihood rather than thoroughly addressing all possible outcomes and phenotypes, respectively. The eXtraordinarY Babies study is a natural history study of children …

Perceived Stress, Social Media Usage, And Sleep Quality In United States Adults, Justine P. Scott

Walden Dissertations and Doctoral Studies

The purpose of this quantitative study was to explore the intricate connections among perceived stress, sleep quality, and social media usage metrics, challenging prior assumptions by highlighting social media as a noteworthy stress coping mechanism. The research aimed to understand the relationship between sleep quality, perceived stress, and the frequency and quality of social media use, guided by the biopsychosocial model as the theoretical framework.The study involved adults aged 20-65. A questionnaire incorporated four validated instruments to assess these variables: the Epworth Sleepiness Scale (ESS), Internet Addiction Diagnostic Questionnaire (IADQ), Perceived Stress Scale (PSS), and Social Media Quality Measure (SMQM). …

Students With Intensive Needs In An Inclusive Education System: A Literature Review, Mohammad Idrees Naeemy, Hiroki Yoneda

Journal of ICSAR

Educating students with various types and degrees of disabilities in regular classrooms remains challenging. Despite the global agenda and push for inclusive education, students with disabilities, particularly those with multiple and severe disabilities, are still being educated in segregated environments. In this qualitative study of peer-reviewed research literature, we aim to understand students with intensive needs (SINs), their current situation in inclusive education systems in developed and developing countries, and the best approaches to how they are being or should be educated in inclusive education systems. The results indicate that students who experience severe challenges in their physical, intellectual, developmental, …

Effect Of Audio Tactile Vocabulary (Atv) Media On Reading Difficulties Of Children With Specific Learning Disorder In Inclusive Elementary School, Ni Made Marlin Minarsih, I Ketut Mahendra

Journal of ICSAR

This research aims to know the effect of Audio Tactile Vocabulary (ATV) media on vocabulary reading ability in children with reading difficulties and with specific learning disorders in inclusive elementary schools—research using a quasi-experimental with quantitative approach. The design is One Group Pretest-Posttest Design—data collection techniques based on interviews, observation, and performance assessment. Data analysis used descriptive statistics. The test results show that the scope of substitution has decreased from 21 wrong vocabulary words to 8 vocabulary words in the scope of omission, and there has been a decrease from 47 wrong vocabulary words to 15 vocabulary words. In the …

Universal Design Learning: Rehabilitation And Inclusive Education In Multidisciplinary Perspective For Inclusive Development, Dewi Anggraini, Yohanes Subasno

Journal of ICSAR

Every person has the right to access educational services, considering that education is one of the most important elements of life in society. More specifically, education can be understood as one of the capitals used by individuals to change the order of their lives in the arena of life in various aspects. The paper aims to show the relevance of rehabilitation for persons with disabilities and inclusive education as a way to achieve inclusive development in the future through Universal Design Learning (UDL). UDL ensures the system of education should focus on the right to quality education for every child, …

Development Of Decodable Books To Improve The Beginning Reading Skills Of Reading Disabilities Students At Primary Schools In Malang, Resty Sushanty, Triya Valentina, Karinda Devinta Putri, Bill Billy, Syalia Nazhiyan Arsanti, Ranti Novianti, Rizqi Fajar Pradipta

Journal of ICSAR

Reading disabilities are someone who experience obstacles in their phonological processes such as identifying letters, distinguishing letter sounds, and their pronunciation, thereby affecting academic development factors, especially aspects of reading. Decodable books can be deciphered and contain code-based phonics learning. This research aims to develop and validate the Decodable book according to the characteristics and needs of students with reading disabilities. This research uses the ADDIE RnD model (Analysis: analysis of needs and characteristics of the subject, Design: design according to initial analysis, Development: design development, Implementation: media application, and Evaluation: evaluation of the entire process). The subjects of this …

Geospatial And How It's Used By Casfer, Eduardo A. Castillo, Olatunde D. Akanbi, Vibha S. Mandayam, Erika I. Barcelos, Roger H. French

Student Scholarship

Project CASFER has a goal to develop the next generation of decarbonized nitrogen based fertilizer. They want to do this by

• Capturing nitrogen from waste, recycling the nitrogen, then producing and distributing CASFER fertilizers to farmers. 

CASFER is made up of 5 different universities that all work together to make up CASFER, Texas Tech University, Case Western University, FAMU, Georgia tech, and MIT.

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Modeling Habitat Suitability And Current Distribution Of The Relicted Maghreb Magpie (Pica Mauritanica), Kamel Eddine Mederbal, Mohcen Menaa, Abdallah Aouadi, Lamia Boutabia, Lamia Bensaâd-Bendjedid, Khalladi Mederbal, Amira Bouderbala, Abderrahmane Chebli, Salah Telailia

Turkish Journal of Zoology

The Maghreb Magpie (Pica mauritanica) is an endemic bird to North Africa, encompassing Algeria, Morocco, and Tunisia. Unfortunately, its population is facing a significant decline primarily attributed to habitat loss and fragmentation resulting from urbanization and agricultural practices. Due to the lack of studies on habitat requirements of Pica mauritanica on a large scale, investigating the habitat preferences of this species and thereby understanding the potential threats, remains crucial for effective conservation strategies. We performed species distribution modeling (SDM), incorporating both occurrence records and predictor variables, to investigate the potentially suitable habitat and the factors influencing the distribution of the …

Identification Of Blood Meals In Field Collected Culex Pipiens, Anopheles Sacharovi And Culex Tritaeniorhynchus (Diptera: Culicidae) Using The Elisa Method, Fatma Bursali, Gi̇zem Anti̇ka, Sare İlknur Yavaşoğlu, Fati̇h Mehmet Şi̇mşek

Turkish Journal of Zoology

Information obtained about the blood feeding behavior of mosquito populations in nature is important for understanding their vectorial capacity and evaluating their potential role in the transmission of vector-borne diseases. This study investigated the feeding patterns of Culex pipiens, Anopheles sacharovi and Culex tritaeniorhynchus by using ELISA method. A total of 435 blood-fed females were collected from the Aegean and Mediterranean regions of Türkiye between May 2021-September 2023. The types and numbers of potential domestic animal hosts were recorded in each village. Of the 372 blood meals tested, 348 gave a single host positive result mainly on bovine and human, …

Parent-Child Interaction And Developing Resilience In Young Children, Seungok Yum

Theses and Dissertations

Early childhood is an especially important period to develop resilience due to social, academic, and emotional benefits for later development. Previous studies pointed out the importance of parent-child interactions, by showing that parental warmth and support can enhance resilience in children by increasing children’s self-esteem and self-regulation. In contrast, hostile parent-child interactions were revealed as risk factors to hinder developing resilience by increasing children’s internalizing symptoms and behavioral difficulties. This study included 85 young children aged 4 to 5 years and 85 parents recruited from the community. Parents completed the Parent Behavior Inventory (PBI) to provide details about two parent-child …

Trec Ikat 2023: A Test Collection For Evaluating Conversational And Interactive Knowledge Assistants, Mohammad Aliannejadi, Zahra Abbasiantaeb, Shubham Chatterjee, Jeffrey Dalton, Leif Azzopardi

Computer Science Faculty Research & Creative Works

Conversational information seeking has evolved rapidly in the last few years with the development of Large Language Models (LLMs), providing the basis for interpreting and responding in a naturalistic manner to user requests. The extended TREC Interactive Knowledge Assistance Track (iKAT) collection aims to enable researchers to test and evaluate their Conversational Search Agent (CSA). The collection contains a set of 36 personalized dialogues over 20 different topics each coupled with a Personal Text Knowledge Base (PTKB) that defines the bespoke user personas. A total of 344 turns with approximately 26,000 passages are provided as assessments on relevance, as well …

Doing Personal Laps: Llm-Augmented Dialogue Construction For Personalized Multi-Session Conversational Search, Hideaki Joko, Shubham Chatterjee, Andrew Ramsay, Arjen P. De Vries, Jeff Dalton, Faegheh Hasibi

Computer Science Faculty Research & Creative Works

The future of conversational agents will provide users with personalized information responses. However, a significant challenge in developing models is the lack of large-scale dialogue datasets that span multiple sessions and reflect real-world user preferences. Previous approaches rely on experts in a wizard-of-oz setup that is difficult to scale, particularly for personalized tasks. Our method, LAPS, addresses this by using large language models (LLMs) to guide a single human worker in generating personalized dialogues. This method has proven to speed up the creation process and improve quality. LAPS can collect large-scale, human-written, multi-session, and multi-domain conversations, including extracting user preferences. …

Understanding The Relationship Between Genetic And Epigenetic Variation At A Species And Individual Level, Kara Quaid

Arts & Sciences Graduate Student Theses and Dissertations

Genetic sequences and epigenetic features work together to regulate gene expression, which can vary across species, individuals, and cell-types. Understanding this relationship between genetics and epigenetics is a key step to revealing the connection between genotype and phenotype on a systematic, genome-wide level. The first chapter of my thesis outlines the ways genetic variation and epigenetic variation may interact to shape gene regulation across scales, as well as how we can question it further. One of the most studied mechanisms is genetic variation that has a direct impact on epigenetic variation. At the species level, it is documented that species-specific …

Moved: Affective Blooms In Online Japanese Literary Media, Laurel Ann Taylor

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation implements affective modes of thick and messy reading practices toward the understanding and analysis of unglamorous literatures originating in Japanese online literary production. The period of study begins with the cellphone novel in the early 2000s and follows the flows of online literary production through the mid-2010s as changes in socio-historical circumstances and technological developments impacted and transformed these literatures. Within this dissertation I contend that we must take into account more quotidian motives for reading—escape, self-soothing, commercial enterprise—especially as they pertain to pop literatures such as cellphone novels, Twitter novels, and Twitter poetry. At the same time, …

The Roles Of Library In Digital Language Documentation Of The Ethnic Minorities Of Bangladesh, Md. Aktarul Islam, Md. Habibur Rahman

Library Philosophy and Practice (e-journal)

From the dawn of human civilization, language has been considered a significant medium for conveying ideas, information, viewpoints, and feelings between one person and another or among a group of people. In Bangladesh, Bengali has been used as the medium of education and communication by the majority of the populace where the languages of ethnic minorities face different challenges, and a good number of languages are on the verge of extinction due to the lack of proper conservation policies and other issues. This paper focused on the roles of libraries in language documentation for ethnic minorities by applying the scientific …

Ragopathies And The Rising Influence Of Raggtpases On Human Diseases, Irene Sambri, Marco Ferniani, Andrea Ballabio

Duncan NRI Faculty and Staff Publications

RagGTPases (Rags) play an essential role in the regulation of cell metabolism by controlling the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and Transcription factor EB (TFEB). Several diseases, herein named ragopathies, are associated to Rags dysfunction. These diseases may be caused by mutations either in genes encoding the Rags, or in their upstream regulators. The resulting phenotypes may encompass a variety of clinical features such as cataract, kidney tubulopathy, dilated cardiomyopathy and several types of cancer. In this review, we focus on the key clinical, molecular and physio-pathological features of ragopathies, aiming to shed light on …

Development And Operationalizing Of The Learning Experience Design Process To Create Integrated Stem Interventions, Vanessa Begat

LSU Doctoral Dissertations

Globally, the demand for people prepared to enter Science, Technology, Engineering and Math (STEM) careers is increasing. To help fill this demand, many formal and informal STEM educational interventions have been implemented in the K-12 domain. However, due to the lack of a clearly defined framework for documenting the nature and scope of the intervention (National Research Council, 2014), the interventions vary greatly in their success, sustainability, and replicability. This research is grounded in Educational Design Research and uses the principle of Learning Experience Design (LXD) to develop a framework for thoughtfully designing and documenting a STEM intervention. This framework …

Inverted Triplications Formed By Iterative Template Switches Generate Structural Variant Diversity At Genomic Disorder Loci, Mira Gandhi, Ming Yin Lun, Michele G Mehaffey, Kyunghee Park, Wolfram Höps, Eva Benito, Patrick Hasenfeld, Jan O Korbel, Medhat Mahmoud, Luis F Paulin, Shalini N Jhangiani, James Paul Hwang, Sravya V Bhamidipati, Donna M Muzny, Jawid M Fatih, Richard A Gibbs, Matthew Pendleton, Eoghan Harrington, Sissel Juul, Anna Lindstrand, Fritz J Sedlazeck, Davut Pehlivan, James R Lupski, Claudia M B Carvalho

Faculty, Staff and Students Publications

The duplication-triplication/inverted-duplication (DUP-TRP/INV-DUP) structure is a complex genomic rearrangement (CGR). Although it has been identified as an important pathogenic DNA mutation signature in genomic disorders and cancer genomes, its architecture remains unresolved. Here, we studied the genomic architecture of DUP-TRP/INV-DUP by investigating the DNA of 24 patients identified by array comparative genomic hybridization (aCGH) on whom we found evidence for the existence of 4 out of 4 predicted structural variant (SV) haplotypes. Using a combination of short-read genome sequencing (GS), long-read GS, optical genome mapping, and single-cell DNA template strand sequencing (strand-seq), the haplotype structure was resolved in 18 samples. …

Longitudinal Program Evaluation Of An Inter-Institutional Mentorship Network For Pediatric Rheumatology Using A Quality Improvement Framework, Peter A Nigrovic, Kelly A Rouster-Stevens, Kaveh Ardalan, Linda Hiraki, L Nandini Moorthy

Faculty, Staff and Students Publications

BACKGROUND: The American College of Rheumatology (ACR)/Childhood Arthritis and Rheumatology Research Alliance (CARRA) Mentoring Interest Group (AMIGO) is an inter-institutional mentorship program launched to target mentorship gaps within pediatric rheumatology. Initial program evaluation indicated increased mentorship access. Given the small size of the pediatric rheumatology workforce, maintaining a consistent supply of mentors was a potential threat to the longevity of the network. Our aims were to: (i) describe the sustainability of AMIGO over the period 2011-2018, (ii) highlight ongoing benefits to participants, and (iii) describe challenges in the maintenance of a mentorship network.

METHODS: A mixed-methods approach centered on a …

Predictive Value Of Has-Bled And Hemorr2hages Bleeding Risk Scores After Percutaneous Coronary Intervention, Ianis Doomun, Daphné Doomun, Sara Schukraft, Diego Arroyo, Selma T Cook, Tibor Huwyler, Jean-Jacques Goy, Jean-Christophe Stauffer, Mario Togni, Serban Puricel, Stéphane Cook

The Texas Heart Institute Journal

BACKGROUND: Various scoring systems have been developed to assess the risk of bleeding in medical settings. HAS-BLED and HEMORR2HAGES risk scores are commonly used to estimate bleeding risk in patients receiving anticoagulation for atrial fibrillation, but data on their predictive value in patients undergoing percutaneous coronary intervention (PCI) are limited.

METHODS: This study evaluated and compared the predictive abilities of the HAS-BLED and HEMORR2HAGES bleeding risk scores in all-comer patients undergoing PCI. The PARIS score, specifically designed for patients undergoing PCI, was used as a comparator. The scores were calculated at baseline and compared with the occurrence of events during …

Barriers To And Facilitators Of Implementing Colorectal Cancer Screening Evidence-Based Interventions In Federally Qualified Health Centers: A Qualitative Study, Bijal A Balasubramanian, Roshanda S Chenier, Maria E Fernandez

Faculty, Staff and Student Publications

Background: There is an urgent need to increase colorectal cancer screening (CRCS) uptake in Texas federally qualified health centers (FQHCs), which serve a predominantly vulnerable population with high demands. Empirical support exists for evidence-based interventions (EBIs) that are proven to increase CRCS; however, as with screening, their use remains low in FQHCs. This study aimed to identify barriers to and facilitators of implementing colorectal cancer screening (CRCS) evidence-based interventions (EBIs) in federally qualified health centers (FQHCs), guided by the Consolidated Framework for Implementation Research (CFIR).

Methods: We recruited employees involved in implementing CRCS EBIs (e.g., physicians) using data from a …

On Emily Dickinson, Katelyn Confer

2024 Symposium

The following paper will explore the relationship between Emily Dickinson’s poetry, the circumstances of her life, and the historical context in which she lived to glean an understanding of how her mental health influenced her work. Selected poems by Dickinson will be reviewed and analyzed, along with a brief overview of nineteenth century attitudes towards female mental health with a particular emphasis on the medical diagnosis of female hysteria.

Vol. 6 No. 1, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.