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Full-Text Articles in Entire DC Network
A Novel Method Of 3d Reconstruction Of Mitochondrial Morphology In Mouse Models Of Alzheimer's Disease, Jonathan Romanes
A Novel Method Of 3d Reconstruction Of Mitochondrial Morphology In Mouse Models Of Alzheimer's Disease, Jonathan Romanes
Undergraduate Student Symposium
Mutations in Amyloid Precursor Protein (APP) and Presenilin 1 and 2 (PS1, PS2) proteins underlie the progression of familial Alzheimer’s Disease (AD). Neurofibrillary tangles and amyloid plaques are the hallmark of AD. The disease mechanism remains elusive, however, mounting data indicate implication of mitochondrial dysfunction and energetic stress early in disease progression. We have previously demonstrated that loss of mitochondrial motility observed in embryonic neurons from APP/PS1 and PS1 transgenic mice was among the earliest abnormalities detected in these animals prior to the loss of mitochondrial function, the onset of memory or neurological phenotype or deposition of amyloid plaques. These …
A Social Interaction Model For The Formation Of Local Hotspots Of Criminal Activity, Dean Gardner
A Social Interaction Model For The Formation Of Local Hotspots Of Criminal Activity, Dean Gardner
Undergraduate Student Symposium
Areas of highly concentrated criminal activity, or hotspots, are a key concern of law enforcement agencies. A large portion of criminal offenses are committed in a relatively small number of these stable zones. We develop a model to study the mechanisms that lead to the formation of these hotspots. In particular we incorporate the contribution of social interactions to the dynamics of the propensity for a criminal agent to act. Hotspots manifest as a form of equilibrium solution of this model. We develop taxonomy of equilibrium solutions based upon the parameters of the model. We explore effectiveness of various strategies …
Agonism In Marine Fish Species, Kory Evans
Agonism In Marine Fish Species, Kory Evans
Undergraduate Student Symposium
The purpose of this experiment was to observe agonistic interactions between juvenile members of the families Haemulidae and Lutjanidae. Both families are salt water fishes whose habitats and diets frequently overlap. Lutjanidae, commonly referred to as snappers, are a critically important commercial and recreational species that are sought after by fishermen worldwide. It is this fishing pressure that is most likely responsible for the decline in global snapper populations.
Traditionally, grunt (Haemulidae) are more abundant than snapper, and it is not entirely understood why. There are notable differences in the behavior of the juvenile members of these two families, with …
Apoptotic Effect Of Lithocholic Acid On Lncap Prostate Cancer Cell Line, Shivali Patel, Nikki Joseph
Apoptotic Effect Of Lithocholic Acid On Lncap Prostate Cancer Cell Line, Shivali Patel, Nikki Joseph
Undergraduate Student Symposium
Lithocholic acid (LCA), CHO is a bile acid naturally produced in the liver that helps to digest fats. LCA has been reported to produce cytotoxic effects on cancer cells while leaving healthy cells unharmed. Recently, based on previous studies conducted, an apoptotic mechanism was proposed for LCA in neuroblastoma (NB) cells, rat glioma cells and breast cancer cells. Therefore, the main purpose of this experiment was to confirm the apoptosis inducing mechanisms of LCA in LNCaP prostate cancer cells. In addition, a combination of LCA and topotecan (TPT), a chemotherapeutic drug, was used to evaluate its potency as well. The …
Are Working Memory And Response Inhibition Correlated With Executive Function?, Laurie Cruz, Lauren Adames, Katie Dabrowski, Shannon Dugan
Are Working Memory And Response Inhibition Correlated With Executive Function?, Laurie Cruz, Lauren Adames, Katie Dabrowski, Shannon Dugan
Undergraduate Student Symposium
Common ailments such as dementia and attention deficit disorders show a decrease in the individual's ability to perform tasks that utilize executive functioning. To measure executive functioning, we focus on two important components: working memory and response inhibition. Working memory measures the ability to handle multiple tasks at once and has been correlated with IQ. Response inhibition is the ability to stop an ongoing response. There is a debate about whether response inhibition and working memory are separate or overlapping functions when performing cognitive tasks. The stop-signal task was used to measure response inhibition under two conditions of high or …
Belief In Paranormal Prophecies: Motivated By Narcissism, The Need For Meaning, Or Self-Focused Sensation Seeking, Laurie Cruz, Scott Earley, Alex Pop
Belief In Paranormal Prophecies: Motivated By Narcissism, The Need For Meaning, Or Self-Focused Sensation Seeking, Laurie Cruz, Scott Earley, Alex Pop
Undergraduate Student Symposium
Many Americans believe in paranormal phenomena despite a lack of credible evidence. The acceptance of systems such as astrology and numerology can leave people vulnerable to financial and emotional exploitation. This study explores personality variables associated with the acceptance of personal information generated by a scientific or astrological system. Participants were randomly assigned to receive either a positive or negative personal statement, generated from either a scientific or an astrological source. The following hypotheses were tested: positive statements would be accepted more than negative statements, participants who exhibit subclinical narcissism will more strongly reject negative statements and will more strongly …
Communication Trends In The Pathographies Of Leiomyosarcoma Patients, Samuel Falk
Communication Trends In The Pathographies Of Leiomyosarcoma Patients, Samuel Falk
Undergraduate Student Symposium
Historically, the term pathography has been interpreted exclusively as written, printed narratives of illness in Hawkins, Reconstructing Illness: Studies in Pathography (1999). Since this publication, the digital age has emerged and new forms of media have become standard tools for communication. Thus, this research expands on the term pathography to include current technological forms of communication as well as printed texts. It explores the recurring trends that comprise Leiomyosarcoma (LMS) pathographies, while incorporating interpretive models from various communication theories as they apply to patients' communication strategies. These theories help to unravel the connotative meaning of LMS patient narratives, which include …
Discovery Of A Branching Coral (Pocillopora Damicornis) Aggregation In Concha Y Perla Lagoon, Galápagos Islands, Ecuador, Francesca Fourney
Discovery Of A Branching Coral (Pocillopora Damicornis) Aggregation In Concha Y Perla Lagoon, Galápagos Islands, Ecuador, Francesca Fourney
Undergraduate Student Symposium
Aggregations of the branching reef-building coral Pocillopora damicornis, located in the Concha y Perla lagoon on Isabela Island, Galapagos Islands, Ecuador, were surveyed in the summer of 2012. This undescribed Pocillopora community is now unique in the archipelago since all other Pocillopora accumulations have been destroyed due to impacts associated with El Niño – Southern Oscillation events. One hundred twenty-two photographic images were taken of the colonies that included approximately 95% of the total coral area. These images were analyzed using CPCe software for live and dead tissue areas as well as colony fragments. Within the surveyed area there …
Environmental Enrichment And Stereotypical Behavior In North American River Otters, Carolina Segarra
Environmental Enrichment And Stereotypical Behavior In North American River Otters, Carolina Segarra
Undergraduate Student Symposium
The goal of this study was to determine factors governing stereotypic behaviors of North American river otters on display at the Palm Beach Zoo. Stereotypic behaviors in captivity occur for no apparent reason, are repetitive and at times may cause harm. Zookeepers strive to provide challenging environments, objects, and activities (enrichments), whether physical, social or mental, to prevent or eliminate stereotypic behaviors and to encourage natural behaviors crucial to animal welfare. For this study, three otters (1 male, 2 females) were chosen based on their consistent stereotypic behaviors. We collected data following an ethogram designed around the natural history of …
Evaluating The Impact Of Cruise Ship Emissions On The Air Quality In South Florida, Aarabhi Rajagopal
Evaluating The Impact Of Cruise Ship Emissions On The Air Quality In South Florida, Aarabhi Rajagopal
Undergraduate Student Symposium
South Florida enjoys the reputation of being the cruise capital of the world, for it has two of the busiest cruise ports in Miami and Fort Lauderdale, respectively. Cruise ships, while bringing tremendous recreational pleasure, emit substantial quantities of gases, such as nitrogen dioxide, and aerosols that pose health risks for the public, especially to those in the elder and sensitive groups. This study attempts to understand the impact of ship emissions on the regional air quality in South Florida. Specifically, the distributions of high and low cruise seasons, as well as heavy and light emission days, are assessed based …
Expression Levels Of Various Proteins In Wild-Type And Transfected Lncap Prostate Cancer Cells, Rebecca Zeller
Expression Levels Of Various Proteins In Wild-Type And Transfected Lncap Prostate Cancer Cells, Rebecca Zeller
Undergraduate Student Symposium
The MDM2 oncogene has become one of the major fields of cancer research since this oncogenic protein is expressed in several common human cancers including prostate cancer. MDM2 interacts with many proteins in the cells such as p53 and leads to over expression of PI3K, HIF-1α, VEGF. Hence exploring the role of alterations associated with these genes at the transcription level has become a major part of our prostate cancer research. LNCaP cells that have been transfected (LNCaP-MSI) with a gene silencer specific for MDM2 was speculated to become a good model for some of our advanced studies in prostate …
Ferling,' The Brightest City Light, Sasha Strelitz
Ferling,' The Brightest City Light, Sasha Strelitz
Undergraduate Student Symposium
Lawrence Ferlinghetti, owner of the famed City Lights Bookstore, is not only considered as the premiere publisher of Beat literature, but he is also an accomplished Beat writer himself. This project will explore the fact that Ferlinghetti’s works mirror themes and stylistic nuances typical of the literature of the Beat Generation. These include: Eastern religious influences, a modernist American perspective, creatively unique poetic alignment, elements of jazz composition and drug experimentation that Beatniks are notorious for, and lastly, methodology that is visibly a legacy of Walt Whitman – for instance, cataloging, eclectic internal rhyme, and a like-minded, all-encompassing moral consciousness. …
Halo Or Noose?, Arielle Mejia-Garcia
Halo Or Noose?, Arielle Mejia-Garcia
Undergraduate Student Symposium
This paper analyzes Coventry Patmore’s “The Angel in the House,” John Ruskin’s “Of Queens’ Gardens,” and Virginia Woolf’s “Professions for Women.” The role of women in the Victorian age was a major issue of dissention which inspired many literary works reflecting divergent viewpoints. The expectations of women are very clearly defined in Ruskin’s essay “Of Queens’ Gardens,” in which he discusses the specific differences and varying capabilities of men and women. Patmore’s poem “The Angel in the House” epitomizes the “ideal” woman and wife, portraying the oppressive standards inflicted upon women of that era. Virginia Woolf's essay, “Professions for Women,” …
Happy Me, Miranda Schumes, Malischa Oge
Happy Me, Miranda Schumes, Malischa Oge
Undergraduate Student Symposium
“Happy Me” is a short documentary film about the lives of four different homosexual students – specifically, how they dealt with their various situations in the past, and how they adapt to life now as college students. The film takes an intimate look at what these people decide to share, and how they are “Happy” as themselves. The film is directed by Miranda Schumes and Malischa Oge.
Histological Techniques Investigating The Occurrence Of Metaplasia In Crassostrea Virginica, Rina Bhalani, Timothy Chung
Histological Techniques Investigating The Occurrence Of Metaplasia In Crassostrea Virginica, Rina Bhalani, Timothy Chung
Undergraduate Student Symposium
The Macondo oil spill occurred in Louisiana bay in 2010. It was caused by the explosion of the Deepwater Horizon oil rig. Approximately 4.9 million barrels of oil were spilled into the waters of the Gulf of Mexico. Although immediate environmental effects were easily observed, studies are now underway investigating the long- term effects of the disaster. This study focuses on the effects on shellfish, in particular the Eastern oyster Crassostrea virginica. It is hypothesized that oysters might have undergone metaplasia in their gills. Metaplasia is the replacement of one cell type with another. Since oysters are filter feeders, …
How Quorum-Sensing Based Synthetic Circuits Have Revolutionized Our Understanding Of Evolutionary Dynamics, Lauren Boudreau
How Quorum-Sensing Based Synthetic Circuits Have Revolutionized Our Understanding Of Evolutionary Dynamics, Lauren Boudreau
Undergraduate Student Symposium
Synthetic biology uses gene circuits to explore and answer fundamental questions in biology. A gene circuit consists of a rationally engineered series of genetic elements all of which interact leading to a novel behavior in a cell. One genetic element that has revolutionized our ability to control cell behavior is quorum sensing, defined as the ability of cells to communicate using small diffusible molecules. Implementation of genetic elements that allow quorum sensing has led to the engineering of gene circuits that have addressed important evolutionary questions in areas such as altruistic cell death, predator-prey growth dynamics, the evolutionary benefits of …
Implicit Attitudes Toward Gay Adoption Through Public Policy Recommendations, Scott Earley
Implicit Attitudes Toward Gay Adoption Through Public Policy Recommendations, Scott Earley
Undergraduate Student Symposium
In the current study, we sought to measure people’s implicit attitudes towards gay adoption. As of today, the review of the scientific literature has revealed little to no effect of parents’ sexual orientation on the long-term psychological well-being of their adoptive children. The belief that straight couples are much better at raising children is therefore likely to be derived from ideology rather than the best available evidence. We investigated people’s feelings on gay adoption. To minimize social desirability bias in participants’ response, the purpose of the study was obscured by distractor questions about other public policy issues and by using …
Landslide Hazards Mapping, Badlands National Park, South Dakota: Applications In Gis, Shari Blaker
Landslide Hazards Mapping, Badlands National Park, South Dakota: Applications In Gis, Shari Blaker
Undergraduate Student Symposium
The goal of this project is to create an interactive hazards map that can be rapidly updated, and used to analyze emerging landslide hazards in Badlands National Park, South Dakota. Digital map technology is a dramatic improvement on the analytical and predictive power of traditional paper maps, allowing us to integrate photographs, digital maps, investigator data and commentary with GIS modeling and analysis. We believe that the Norbeck Ridge Slide, which is approximately 814 meters and is adjacent to State Route 240, the main road into the Badlands National Park, is an intermittently active, slump-induced slide with destructive potential. Ephemeral …
Lord British Is Dead: An Analysis Of The Execution And Consequences Of Emergent Gameplay Within Massively Multiplayer Online Video-Game Communities, Joseph Cirino
Undergraduate Student Symposium
It is a common perception that video-games contain rules and restrictions that force players to react in specific ways to a variety of situations. The milieu of games are rightfully believed to put a limit on player responses as intended by the developers of such games, for video-games are simply graphical representations of programmed environments. While video-games provide an accepted form of social interaction and traditional problem-solving based on pre-created environments of game design, it also creates unprecedented opportunities for players to create revolutionary new forms of play that are not expected by the developers of the game.
The patterns …
Madness: Sense, Consequence, And Freedom, Melissa Villalobos
Madness: Sense, Consequence, And Freedom, Melissa Villalobos
Undergraduate Student Symposium
This essay analyzes the shared plight of Bertha Mason, from Charlotte Brontë’s Jane Eyre, and the protagonist from Charlotte Perkins Gillman’s “The Yellow Wallpaper” against the backdrop of prevailing gender and societal attitudes in the mid and late 19th century. The paper argues that in spite of gender roles advocating male dominance and female submissiveness that imprison them, both “madwomen” find enlightenment and qualified autonomy in their attic of seclusion, consistent with the ethos of the time in which each author wrote.
Model System For Design Of A Medical Diagnostic Device: Hemoglobin A1c, Jose Cabrera, Ifaz Parvez, Natalie Buzaglo, Oliver Moreira
Model System For Design Of A Medical Diagnostic Device: Hemoglobin A1c, Jose Cabrera, Ifaz Parvez, Natalie Buzaglo, Oliver Moreira
Undergraduate Student Symposium
The country is experiencing a dramatic increase in the incidence of Diabetes Type II. In an effort to develop a medical device to both screen and monitor for Diabetes, we commenced a research project that embraced a team approach.
The overall objective was the design and development of a simple device that measures glycated hemoglobin, referred to as hemoglobin A1c, by electrochemical means. Patient blood can be accessed by finger prick, and after applying a drop of the blood to a device, lysis occurs by hemolyzing agents. Enzymatic activity will then perform the following steps: (a) digestion of the hemoglobin …
Neural Stem Cells Proliferate In Vascular Niches In The Adult Mayan Cichlid Brain, Ahmed Ali, Jonathan P. Romanes, Sameed Ashfaq, Joseph V. Dellavecchia
Neural Stem Cells Proliferate In Vascular Niches In The Adult Mayan Cichlid Brain, Ahmed Ali, Jonathan P. Romanes, Sameed Ashfaq, Joseph V. Dellavecchia
Undergraduate Student Symposium
The birth of new neurons (neurogenesis) has been observed in all adult mammalian brains examined to date. Adult neural stem cells are located close to blood vessels in each of the two neurogenic regions observed in all mammals. A regulatory role for blood vessels has recently been suggested as a mechanism to regulate neurogenesis. In recent studies, postnatal neurogenesis has been reported in several regions of the fish brain including the olfactory bulb, dorsal zones of the telencephalon, hypothalamus, and divisions of the cerebellum. While fish brain is reported to contain more neurogenic regions than mammalian brain, little else is …
No Service, Lauren Mcgarrett
No Service, Lauren Mcgarrett
Undergraduate Student Symposium
“No Service” is a short film about a young college student named Katy, who is constantly dependent upon her technological devices. When her smartphone and laptop are suddenly stolen, her life is sent into chaos. How will she make it through the day when even the most basic of everyday activities become difficult for her? The film is directed by Lauren McGarrett.
Nucleotide Excision Repair: A New Component In The Study Of Breast Cancer, Monica Azer
Nucleotide Excision Repair: A New Component In The Study Of Breast Cancer, Monica Azer
Undergraduate Student Symposium
Breast cancer is a prevalent cancer that occurs in many women and men today. There are many exogenous and endogenous causes of DNA damage as well as a multitude of repair mechanisms to fix the damage; however, if it is not fixed, the damage becomes a permanent mutation. A series of these mutations lead to cancer. Deficient Nucleotide Excision Repair (NER) is being studied as one of the main mechanisms of carcinogenesis. Deficient NER was found in stage I breast cancers as compared to normal breast epithelium and may be due to over-expression of microRNA. In order to verify this …
Porphyrin Geometry- Associated Energy And Binding Conformation, Jessica Millar
Porphyrin Geometry- Associated Energy And Binding Conformation, Jessica Millar
Undergraduate Student Symposium
Meso substituted cationic porphyrins are large, naturally occurring macrocylces that are highly substituted, thereby giving them a wide variety of unique properties including the ability bind to DNA. The degree of distortion of these porphyrins caused by peripheral substitution can determine each molecules particular type of binding to DNA sequences. Previous studies have shown that highly substituted porphyrins with less planar conformations (such as saddle, ruffle, wave, etc.) often have a harder time binding to regions of DNA due to an increase in steric clashes and a larger destabilization of the strand. This experiment’s focus is the relationship between conformation …
Repeatability Of Prebrush And Postbrush Plaque Measured Via Image Analysis, Nohora Duque
Repeatability Of Prebrush And Postbrush Plaque Measured Via Image Analysis, Nohora Duque
Undergraduate Student Symposium
Objective: This research used image analysis to evaluate the reproducibility of natural plaque accumulation and removal measured instrumentally.
Method: After institutional review and informed consent, healthy adults were enrolled in a study to assess the between-visit consistency of plaque measurement for overnight and post-brush plaque. At Day 1, subjects with overnight (unbrushed) plaque swished with a fluorescein rinse and expectorated, cheek retractors were inserted, and a single digital image was collected under standardized lighting conditions. After routine hygiene with a regular anticavity dentifrice (Crest® Cavity Protection) and standard manual toothbrush, disclosing and imaging were repeated. Approximately 1-week later, the imaging-brush-imagining …
Side-Bridge Hold Times Are Not Related To Injury Prevalence In Female Rowers, Amber Morrell
Side-Bridge Hold Times Are Not Related To Injury Prevalence In Female Rowers, Amber Morrell
Undergraduate Student Symposium
Rowing injuries are primarily overuse related and occur commonly to the knee, lumbar spine and ribs. Core tests of strength, stability and/or endurance are used in clinical practice to predict injury. The side-bridge hold test (SBH) is a valid and reliable test of core endurance with female norms of 75±.32 and 78±.32 seconds for right and left sides. The purpose of this study was to determine if SBH performance can predict core injuries (ribs, lumbar spine, hip, knee) in intercollegiate female rowers (ROW). A sample of convenience was utilized; 33 ROW free of recent musculoskeletal injury performed the SBH on …
Synthesis Of The Next Compound In A Homologous Series Of Metal-Organic Frameworks, Rachel Salveson
Synthesis Of The Next Compound In A Homologous Series Of Metal-Organic Frameworks, Rachel Salveson
Undergraduate Student Symposium
Porous compounds, clays and activated charcoal, have been used as adsorbents in a number of different settings such contrast for x-rays in the medical field. Unfortunately, these adsorbents are not very selective and adsorb just about everything. A new class of adsorbents known as MOF's have become of great interest because these materials are easily altered synthetically and thus offer the promise of improved control over selectivity.
Our interest has been in the derivatives of NBAII, shown below. Notice that structure A has one six membered ring in the backbone while structure B has two. When crystals of these molecules …
The Effects Of Pre Versus Post Exercise Consumption Of An Amino-Acid Based Nutritional Supplement: Effects On Body Composition And Performance, Anamaria Cretu, Sapphire Aragon
The Effects Of Pre Versus Post Exercise Consumption Of An Amino-Acid Based Nutritional Supplement: Effects On Body Composition And Performance, Anamaria Cretu, Sapphire Aragon
Undergraduate Student Symposium
Purpose: The role of nutrient timing in combination with heavy resistance is unclear. There is research to suggest that the consumption of protein pre- or post-exercise may enhance muscular size and strength. The purpose of this investigation was to ascertain the effects Pre versus Post exercise consumption of an amino-acid based supplement (NO Synthesize®) as it relates to the adaptive response to exercise.
Methods: Twenty healthy (n=20) well trained adult males and females (21.6 yrs ± 4.3, 67.9kg ± 9.8, 170.0cm ± 11) were recruited to participate in this 28 day intervention. Subjects were given informed consent and were subsequently …
The Influence Of Alcohol And Caffeine On Cockroach Motor Function, Isaac Chayo
The Influence Of Alcohol And Caffeine On Cockroach Motor Function, Isaac Chayo
Undergraduate Student Symposium
The cockroach has proven to be an excellent model for investigating the pharmacological effects of different substances on nervous system functionality. The increased vigilance and wakefulness associated with caffeine is primarily mediated by its interactions with monoamine neurotransmitters in addition to its role as an antagonist for adenosine receptors. In the case of alcohol, it is an agonist for the inhibitory neurotransmitter GABA, which partly explains its sedative properties and disruptive effects on motor function. In this experiment, we will examine the influence of caffeine and alcohol on motor function in Blaberus Discoidalis by designing an enclosed running strip marked …