Digital Commons Network^™

Consensus Pharmacophore Strategy For Identifying Novel Sars-Cov-2 Mpro Inhibitors From Large Chemical Libraries, Angel J Ruiz-Moreno, Raziel Cedillo-González, Luis Cordova-Bahena, Zhiqiang An, José L Medina-Franco, Marco A Velasco-Velázquez

The Brown Foundation: Institute of Molecular Medicine

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main Protease (Mpro) is an enzyme that cleaves viral polyproteins translated from the viral genome and is critical for viral replication. Mpro is a target for anti-SARS-CoV-2 drug development, and multiple Mpro crystals complexed with competitive inhibitors have been reported. In this study, we aimed to develop an Mpro consensus pharmacophore as a tool to expand the search for inhibitors. We generated a consensus model by aligning and summarizing pharmacophoric points from 152 bioactive conformers of SARS-CoV-2 Mpro inhibitors. Validation against a library of conformers from a subset of ligands showed that …

Quality Of Life After A Prostatectomy In Men Who Have Sex With Men, Jéaux Alexander Rinedahl

Walden Dissertations and Doctoral Studies

No abstract provided.

North Park Holdings, Llc Appellant V. Duke Rental Co, Llc, Appellee : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

APPEAL FROM THE FIRST JUDICIAL DISTRICT COURT CACHE COUNTY, STATE OF UTAH HONORABLE SPENCER WALSH

Matthew N. Evans, Attorneys for Appellee

Joseph M. Chambers, Attorneys for Appellant

Tamara Lee Powell, Appellant V. Dean Deloy Powell, Appellee : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from a Judgment of the Third Judicial District Court Salt Lake County, Honorable Mark Kouris

Dennis R. James, Attorney for Appellant

David Corbett, Attorney for Appellee

S ( M ) Othering: A Rhetorical Analysis Of Republican Motherhood, Caroline King

Theses and Dissertations

This study examines seven Republican rhetors who utilize motherhood as a rhetorical strategy in speeches between the years of 1972 and 2020. Specifically, speeches, newsletters, and debate transcripts are analyzed using four theoretical lenses to curate an archetype of the “Republican Mother” – a concept constructed of an amalgamation of the historic “mother of the republic” from the nation’s conception and the ideological values assigned to women within the Republican party, such as traditional gender and spousal roles. I argue that it is the unique combination of womanhood, motherhood, and Republicanism that creates a unique rhetorical strategy seen in these …

High-Accuracy Reconstruction Of Missing Ground-Penetrating Radar Signals Based On Projection Onto Convex Sets In The Curvelet Domain, Wu Qiming, Wang Honghua, Xi Yuhe, Wang Yucheng

Coal Geology & Exploration

Influence by the acquisition environments and instrument performance, missing signals and destructed channels are inevitable in measured ground-penetrating radar (GPR) profiles. They can cause event discontinuity of reflected and diffracted waves generated by targets, severely impairing the accuracy and resolution of subsequent processing and imaging. Hence, by combining the projection onto convex sets (POCS) algorithm extensively used in image processing with the curvelet transform exhibiting high sparsity, this study proposed a high-accuracy reconstruction method for missing GPR signals based on curvelet-domain POCS. Building on the compressive sensing theory, the objective function for missing signal reconstruction based on discrete curvelet transform …

Profiles Of Latinx Cultural Orientation Among Adolescents: Associations With Internalizing Symptoms And Moderation By Ethnic-Racial Discrimination, Miriam Ortiz, Fantasy T. Lozada, Oswaldo Moreno, Chelsea D. Williams, Brendesha M. Tynes

Psychological Science Faculty Publications

Introduction: The objectives of the current study were the following: (1) to explore multidimensional profiles of Latinx cultural orientation using Spanish language use, familismo, and ethnic-racial identity (ERI) affirmation among Latinx adolescents, (2) to test how Latinx cultural orientation profiles were associated with adolescents' internalizing symptoms (i.e., depressive symptoms and anxiety symptoms), and (3) to test whether associations between profiles and internalizing symptoms were moderated by adolescents' ethnic-racial discrimination experiences.

Methods: The study was conducted among a sample of 204 Latinx adolescents (52.4% female; Mage = 14.35, SDage = 1.75).

Results: Latent profile analysis indicated four profiles of Latinx cultural …

Dissociating Reading And Auditory Comprehension In Persons With Aphasia, Rachael M. Harrington, Sigfus Kristinsson, Janina Wilmskoetter, Natalie Busby, Dirk B. Den Ouden, Chris Rorden, Julius Fridriksson, Leonardo Bonilha

Communication Sciences and Disorders Faculty Articles and Research

Language comprehension is often affected in individuals with post-stroke aphasia. However, deficits in auditory comprehension are not fully correlated with deficits in reading comprehension and the mechanisms underlying this dissociation remain unclear. This distinction is important for understanding language mechanisms, predicting long-term impairments and future development of treatment interventions. Using comprehensive auditory and reading measures from a large cohort of individuals with aphasia, we evaluated the relationship between aphasia type and reading comprehension impairments, the relationship between auditory versus reading comprehension deficits and the crucial neuroanatomy supporting the dissociation between post-stroke reading and auditory deficits. Scores from the Western Aphasia …

Mochon, Lynne, Patricia Scully

Bronx Jewish History Project

Summarizer: Sophia Maier

Lynne Mochon, born 1951, grew up on the campus of Maritime College. Her father, who left Warsaw in 1922, was educated in pre-state Israel and then MIT, before becoming a professor of science at Maritime. Her mother, born in Queens, worked at Maritime, and, as the only Jewish people working there together at the time, they got married, have Mochon and her older sister. Mochon describes Maritime as a small community of about 14 families, where the children were similar in age and played together by the water. She remembers some antisemitism among the staff, her father …

Improving The Accuracy Of Medical Records In Healthcare Institutions, Tarkessa Frazier

Walden Dissertations and Doctoral Studies

No abstract provided.

The Effect Of Teacher Identity On The Level Of Cultural Inclusion In The Classroom, Jennifer Jones

Dissertations

The purpose of this qualitative phenomenographical study was to investigate high school teachers’ perceptions of cultural inclusion and the impact of teacher identity on the level of cultural inclusion in the classroom. This research study utilized semi-structured one-on-one interviews as the primary source of data and participant surveys and researcher notes taken during the interviews as the secondary sources. This study sought to address two research questions: (1) What can we learn from teachers' experiences at a southeastern suburban high school regarding the post-COVID perceptions of cultural inclusion in the classroom? (2) How does teacher identity affect cultural inclusion in …

News Deserts And Voter Turnout: How Local News Shortages Decrease Voter Participation, Lauren Penington

Honors Program: Senior Projects (Public)

How does local news impact a county’s registered voter population, associated voting patterns, and political participation? Electoral turnout is one of the most studied topics in political science, and substantial research exists into demographic factors — including race, age, and socioeconomic status — that influence an individual’s likelihood to vote. Recent studies have begun to examine the impact of societal factors — such as the internet, social media, and news — on an individual’s ability to and likelihood of fulfilling their civic obligation. This paper explores the relationship between expanding news deserts and decreasing voter turnout, proposing that as a …

Adolescent Algorithm Addiction, Canyon Skare

Honors Program: Senior Projects (Public)

There’s no question that online Social Networking Sites have contributed to the sharp decline in mental health among adolescents. This thesis explores a number of Addictive Online Behaviors that have contributed to negative mental health outcomes, namely examining at total screentime, level of engagement, and total number of accounts one has in relation to phone addiction and social media addiction. It was found that total screentime and total number of accounts were more strongly correlated with social media addiction than phone addiction. Additionally, differences in app usage among gender was explored, finding that boys favored YouTube and Discord while Girls …

Dopamine Lesions Alter The Striatal Encoding Of Single-Limb Gait, Long Yang, Deepak Singla, Alexander K Wu, Katy A Cross, Sotiris C Masmanidis

Faculty, Staff and Student Publications

The striatum serves an important role in motor control, and neurons in this area encode the body's initiation, cessation, and speed of locomotion. However, it remains unclear whether the same neurons also encode the step-by-step rhythmic motor patterns of individual limbs that characterize gait. By combining high-speed video tracking, electrophysiology, and optogenetic tagging, we found that a sizable population of both D1 and D2 receptor expressing medium spiny projection neurons (MSNs) were phase-locked to the gait cycle of individual limbs in mice. Healthy animals showed balanced limb phase-locking between D1 and D2 MSNs, while dopamine depletion led to stronger phase-locking …

Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Affects Nitrate Metabolism, But Not Vascular Function Or Blood Pressure In Older Adults With Hypertension, Rebeka Fejes, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Karl-Heinz Wagner, Hans-Peter Stüger, Jonathan M. Peake, Richard J. Woodman, Kevin D. Croft, Catherine P. Bondonno, Jonathan M. Hodgson, Michael Wolzt, Oliver Neubauer

Research outputs 2022 to 2026

The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via nitric oxide (NO) translate into improved vascular function and blood pressure-lowering in 15 men and women (age range: 56-71 years) with treated hypertension. We investigated the effects of a single ∼400 mg-dose at 3 hours post-ingestion (3H POST) and the daily consumption of 2 × ∼400 mg of nitrate through nitrate-rich compared with nitrate-depleted (placebo) beetroot juice over 4 weeks (4WK POST). Measurements …

In Silico Analysis Of C-Type Lectins As Co-Infection Receptors Of Dengue And Chikungunya Viruses In Aedes Aegypti, Munawir Sazali, R. C. Hidayat Soesilohadi, Nastiti Wijayanti, Tri Wibawa, Arif Nur Muhammad Ansori

Makara Journal of Science

Aedes aegypti is a primer vector of dengue virus (DENV) and chikungunya virus (CHIKV). The susceptibility of mosquitoes to DENV and CHIKV depends on their recognition receptor of pathogens. C-type lectins (CTLs) are an important mediator of virus infection in A. aegypti. This study aims to identify potential receptors and determine the binding affinity between ligand–receptor interaction, CTLs and virus envelopes (DENV-1, 2, 3, and 4 and CHIKV) interaction based on in silico analysis. Sample sequences were obtained from GenBank (NCBI), and 10 CTLs were acquired from VectorBase. Homology modeling based on a minimum standard of 20% was processed …

An Analysis Of Ben Moore’S Comedy Songs Using J. Peter Burkholder’S Music-Borrowing Techniques, Bradley Sowell

Electronic Theses and Dissertations Archive

Ben Moore's comedy songs have found favor as the final song on recitals due to their humor. In addition to those themes, the songs have continued a compositional style using music-borrowing techniques. J. Peter Burkholder was the first researcher to codify a set of specific techniques outside the designation of "quotation" or "parody." Using the methodology of Burkholder, Moore's comedy songs and their uses of existing music can be analyzed and situated in the musical borrowing field of study. The techniques found in Moore’s songs include paraphrase, quotation, stylistic allusion, quodlibet, and interjection. Paraphrase is when the borrowed music is …

Mitigation Of Potential Risks In Chemical Laboratories: A Focused Review, Hossein Abedsoltan, Mark B. Shiflett

Chemical and Biochemical Engineering Faculty Research & Creative Works

This review paper presents an analysis of safety practices in chemical laboratories. It encompasses a systematic exploration of various facets including risk assessment, hazard mitigation, and the implementation of safety protocols. Emphasis is placed on the critical role of continuous education and training, advocating a proactive safety culture, and adapting to technological advancements. Additionally, the paper underscores the importance of adhering to regulatory standards, promoting exceeding baseline compliance toward establishing best practices in laboratory safety. This comprehensive approach highlights the dynamic, multifaceted nature of laboratory safety, positioning it as a fundamental aspect of scientific research.

Factorization In Cybersecurity: A Dual Role Of Defense And Vulnerability In The Age Of Quantum Computing, Himateja Arukala

Theses and Dissertations

One of the most critical components of modern cryptography and thus cybersecurity is the ability to factor large integers quickly and efficiently. RSA encryption, one of the most used types, is based largely on the assumption that factoring for large numbers is computationally infeasible for humans and computers alike. However, with quantum computers, people can use an algorithm like Shor’s algorithm to perform the same task exponentially faster than any normal device ever could. This investigation will go into the strength and vulnerability of RSA encryption using the power of factorization in an age of quantum computers.We start by looking …

Towards A Blockchain-Based Data Trading Protocol, Manish Adhikari

Theses and Dissertations

In an era where Artificial Intelligence (AI) and the Internet of Things (IoT) are pushing data to the forefront of industrial and academic pursuits, the dynamics of data trading are rapidly evolving. Blockchain technology, celebrated for its inherent security features like non-repudiation and traceability, plays a critical role in this transformation. However, integrating blockchain into data trading platforms presents significant challenges, especially in achieving the sophisticated security properties required for practical applications.

This thesis introduces a blockchain-based Secure Data Trading (SDT) protocol, crafted to refine the security frameworks of data exchange platforms by emphasizing two critical aspects: data multiple sellability …

A Clinical Practice Guideline For The Management Of Patients With Acute Spinal Cord Injury: Recommendations On Hemodynamic Management, Brian K. Kwon, Lindsay A. Tetreault, Allan R. Martin, Paul M. Arnold, Rex A.W. Marco, Virginia F.J Newcombe, Carl M. Zipser, Stephen L. Mckenna, Radha Korupolu, Chris J. Neal, Rajiv Saigal, Nina E. Glass, Sam Douglas, Mario Ganau, Vafa Rahimi-Movaghar, James S. Harrop, Bizhan Aarabi, Jefferson R. Wilson, Nathan Evaniew, Andrea C. Skelly, Michael G. Fehlings

Department of Neurosurgery Faculty Papers

STUDY DESIGN: Clinical practice guideline development following the GRADE process.

OBJECTIVES: Hemodynamic management is one of the only available treatment options that likely improves neurologic outcomes in patients with acute traumatic spinal cord injury (SCI). Augmenting mean arterial pressure (MAP) aims to improve blood perfusion and oxygen delivery to the injured spinal cord in order to minimize secondary ischemic damage to neural tissue. The objective of this guideline was to update the 2013 AANS/CNS recommendations on the hemodynamic management of patients with acute traumatic SCI, acknowledging that much has been published in this area since its publication. Specifically, we sought …

Tmem106b Coding Variant Is Protective And Deletion Detrimental In A Mouse Model Of Tauopathy, George A Edwards, Caleb A Wood, Yang He, Quynh Nguyen, Peter J Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L Jankowsky

Duncan NRI Faculty and Staff Publications

TMEM106B is a risk modifier of multiple neurological conditions, where a single coding variant and multiple non-coding SNPs influence the balance between susceptibility and resilience. Two key questions that emerge from past work are whether the lone T185S coding variant contributes to protection, and if the presence of TMEM106B is helpful or harmful in the context of disease. Here, we address both questions while expanding the scope of TMEM106B study from TDP-43 to models of tauopathy. We generated knockout mice with constitutive deletion of TMEM106B, alongside knock-in mice encoding the T186S knock-in mutation (equivalent to the human T185S variant), and …

Hazardous Explosive Eruptions Of A Recharging Multi-Cyclic Island Arc Caldera, Jonas Preine, Jens Karstens, Christian Hübscher, Tim Druitt, Steffen Kutterolf, Paraskevi Nomikou, Michael Manga, Ralf Gertisser, Katharina Pank, Sarah Beethe, Carole Berthod, Gareth Crutchley, Iona Mcintosh, Thomas Ronge, Masako Tominaga, Acacia Clark, Susan Debari, Raymond Johnston, Zenon Mateo, Ally Peccia, Christopher Jones, Günther Kletetschka, Abigail Metcalfe, Alexis Bernard, Hehe Chen, Shun Chiyonobu, Tatiana Fernandez-Perez, Kumar Batuk Joshi, Olga Koukousioura, Molly Mccanta, Antony Morris, Paraskevi Polymenakou, Adam Woodhouse, Yuzuru Yamamoto, Kuo Lung Wang, Hao Yang Lee, Xiaohui Li, Dimitrios Papanikolaou

School of Geography, Earth and Environmental Sciences

Caldera-forming eruptions of silicic volcanic systems are among the most devastating events on Earth. By contrast, post-collapse volcanic activity initiating new caldera cycles is generally considered less hazardous. Formed after Santorini’s latest caldera-forming eruption of ~1600 bce, the Kameni Volcano in the southern Aegean Sea enables the eruptive evolution of a recharging multi-cyclic caldera to be reconstructed. Kameni’s eruptive record has been documented by onshore products and historical descriptions of mainly effusive eruptions dating back to 197 bce. Here we combine high-resolution seismic reflection data with cored lithologies from International Ocean Discovery Program Expedition 398 at four sites to determine …

Advocacy Connection Team-Now Educational Program For Headache Fellows And Patients/Caregivers: Assessment Of Educational Objectives, Courtney Seebadri-White, Hsiangkuo Yuan, William B. Young, Karissa N. Arca

Department of Neurology Faculty Papers

OBJECTIVE: To assess for improvement in comfort in participating in advocacy for migraine and headache disorders and knowledge needed for successful advocacy.

BACKGROUND: The Advocacy Connection Team (ACT)-Now program is an educational program offered through Miles for Migraine, a non-profit advocacy organization. It is designed to teach headache fellows and patients advocacy skills.

METHODS: In a cross-sectional pre-test-post-test design, the 2021 ACT-Now cohort of 98 participants were administered a set of 11 pre-course survey questions identifying their role (healthcare provider/headache fellow or patient/caregiver), baseline knowledge of migraine-related disability and stigma, and baseline engagement and comfort with advocating. The post-course survey …

Patterns Of Social Responsibility Among Gifted Students And Their Relationship To Certain Variables, Suhair Al-Tal, Fuad Al-Jawaldeh, Heyam Al-Taj, Wafaa Al-Eid

Jordan Journal of Applied Science-Humanities Series

The current study aimed to identify the degree of prevalence of social responsibility patterns among gifted students in schools in Cairo during the second semester of the academic year 2019/2020. The study sample consisted of 196 male and female students from grades eight and ten, all of whom achieved an average of 90% or higher. The sample included 102 female students and 94 male students. The researchers developed and applied a social responsibility scale encompassing three patterns: self, family, and social, after verifying its validity and reliability. The results indicated that the prevalence of social responsibility patterns among gifted students …

Developmental Differences In Reported Speech And Internal State Language In Preschoolers’ Personal Narratives, Megan E. Welliver, Alice J. Davidson, Alexandra Mccrary

Faculty Publications

The present study explored developmental differences in preschoolers’ use of reported speech and internal state language in personal narratives. Three-, four-, and five-year-olds attending a laboratory preschool shared 204 stories about ‘a time when you were happy/sad’. Stories were audio-recorded, transcribed, and coded for reported speech (direct, indirect, narrativized) and internal state language (cognitive states, total emotion terms, unique emotion terms). Personal narratives told by five-year-olds included more cognitive states and more narrativized speech than those told by three- and four-year-olds, even when accounting for children’s vocabulary skills, and that reported speech (narrativized, direct) were positively correlated with cognitive state …

The Chronicle, Kennedy Ballinger, Lara Jones, Dashae Engler, Bella Perez, Emily Riley, Riley Dickerson, Maya Pierce, Andy Langager

Campus Chronicle

No abstract provided.

Ohio’S Failure To Protect Motorcyclists' Heads: A Law Enforcement Perspective, B. Thomas

Et Cetera

As a former police officer, the aftereffects of helmetless motorcycle crashes will forever haunt me. This Article discusses the need for helmet laws for all motorcyclists.

Inequitable By Design: The Strategic Distribution Of Costs And Benefits By Business Improvement Districts And Special Assessments, Molly Gillespie

Et Cetera

Business Improvement Districts (BIDs) are most commonly credited for their innovative strategies in rejuvenating the economic vitality in American cities. However, their implementation raises concerns about fairness and equity. The current practice of financing BIDs through special assessments, particularly applying the front footage method, disproportionately burdens certain property owners for the benefit of others. Consequently, property owners face a range of issues, including financial strain, involuntary annexation, and potential threats to property ownership. However, the existing framework of state constitutions lack the necessary provisions to adequately address these challenges, underscoring the need for significant reform.

This Note addresses these concerns …

The Invasive Bank Vole (Clethrionomys Glareolus); A Longitudinal Investigation Into Rodents And Their Pathogen Communities, Using The Irish Rodent Invasion As A Model System., Andrew Mcmanus

Theses

The recent emergence of zoonotic pathogens such as, SARS-CoV-2, Ebola and Mpox, have emphasised the necessity to study wildlife and their pathogens. A knowledge gap currently exists in longitudinal studies of biological invasions, which are needed to understand the change in pathogen communities caused as the invader becomes more established. The invasion of Clethrionomys glareolus in Ireland provides a unique model system to study these changes at different stages of the bio-invasion. This is due to the depauperate small mammal community in Ireland, identifiable source population, introduction point, and ongoing expansion of C. glareolus in Ireland. Extensive work has been …