Digital Commons Network^™

Directing A Technical Cyclone, Leonard A. Lively

Theses

In October 2023, the Southern Illinois School of Theater and Dance produced Ride the Cyclone. This thesis documents the participation of the technical director, Leonard Lively, in this collaborative production process. The project involved multimedia construction, CNC technology to manufacture custom components, curtain fabrication, engineering inspiration from anatomical structures, and advanced AutoCAD drafting techniques. Chapter one explores the play’s text, past productions, and the production’s possibilities. The design process is documented in the second chapter. The third chapter covers the production process and the fourth chapter reflects and evaluates the effectiveness of the production.

The Deaf Experience In National Parks With An Emphasis On Rocky Mountain National Park, Madeline Dannewitz

Undergraduate Honors Theses

This research investigated the experiences of Deaf visitors to the Rocky Mountain National Park (RMNP). The little research available focuses on how the National Park Service and its workers interact with Deaf people. Conversely, this study investigated the experiences of Deaf people and their perspective regarding interacting with the park and its members. A study regarding Deaf visitors in Yosemite National Park found that many were invisible to its employees. The desire from the Deaf community and lack of research shows the significance of this study. This analysis is crucial to the human experience as quality of life is improved …

Evaluating Auditory Processing In Adolescents And Adults Following A Sports-Related Concussion, Kelsey Danielle Kiesz

Doctoral Scholarly Projects & Capstones

Sports-related concussions (SRCs) have gained increasing attention in recent years due to the long-lasting effects. While concussions have been extensively studied, the impact on auditory processing in adolescents and adults remains an under-evaluated area within audiology. This gap in research is noteworthy as audiologists are well-positioned to conduct auditory processing disorder (APD) testing, and post-concussion auditory deficits fall within the scope of their practice. This study addresses the lack of consensus on concussion definitions, limited accurate prevalence data, and the absence of guidelines for assessing auditory processing in post-concussion individuals in the audiology field. The research aims to provide a …

Analyzing The Relationship Between Cannabis Use And Hearing Loss, Ashley Howe

Doctoral Scholarly Projects & Capstones

The purpose of this study was to assess the cross-sectional relationship between cannabis use and hearing thresholds to determine if cannabis use is associated with poorer hearing sensitivity while controlling for covariates and other risk factors in a large population-based data set. To answer this question, we analyzed audiometric hearing threshold data, drug use data, and covariate data from the U.S. National Health and Nutrition Examination Survey (NHANES) cycles. A total of 5,140 participants from 2009–2012 and 2015–2016 aged 20–59 years were included in the analyses. Univariable and multivariable main effects logistic regression models were used to compare cannabis use …

Ototoxicity Monitoring Protocols For Common Chemotherapeutics, Megan Pamela Kennedy

Doctoral Scholarly Projects & Capstones

Cancer is a major public health concern and is increasingly prevalent worldwide. Sung et al. (2021) states that there were 19.3 million new cases of cancer across the globe, and almost 10 million deaths related to cancer in 2021. Sung et al. (2021) also notes that the United States accounts for 8% of all global cases, with an average of 1.7 million new cases annually. The top five most common adult cancers in the United States include: (1) breast, (2) prostate, (3) lung and bronchus, (4) colorectal, and (5) invasive melanoma of the skin. These cancers can be treated with …

A Muzzle For The Lamb: A Novel, Scott Beggs

Open Access Theses & Dissertations

No abstract provided.

Effect Of Patient Specific Blood Biomarkers On Nanoparticle - Cell Interactions, Veronica Gabriela Contreras

Open Access Theses & Dissertations

Nanoparticles are currently known to be a promising material class for bio-applications in drug delivery and vaccine development. Using gold nanoparticles of varied sizes, in this case 45 and 100 nanometers as a model nanomaterial system, we investigated how patients' blood physiology and chemistry (such as solute, protein, lipid levels) affect the biological response to bionanomaterials. When nanoparticles are injected into the body, biomolecules in the blood adsorb to the nanoparticle's surface to form a biomolecular corona that is specific to the patient's unique blood composition. This biomolecular corona is important because it affects the in vivo fate and biodistribution …

Water Sufficiency For Organismal Function In Dryland Critical Zones, Lindsey Dacey

Open Access Theses & Dissertations

Water availability is crucial for organismal survival and growth in dryland environments, affecting both ecological interactions and carbon dynamics. The goal of this thesis is to develop soil water release curves (SWRCs) that link soil water potentials (Ψ) to soil water content (θ). Using the SWRCs, temporal soil water sufficiency curves are developed, which quantify the amount of time that dryland critical zones have enough water to sustain the physiology of organisms. These curves allow for effectively indicating water availability across different species, coverage types, and soil conditions, enhancing our understanding of water dynamics in drylands and contributing important parameters …

Conserving One Of Hawai'i'S Last Endemic Ducks: Genetics And Habitat Associations Of Koloa, Feral Mallards, And Their Hybrids, Kristi Fukunaga

Open Access Theses & Dissertations

Increases in anthropogenic hybridization through introduced species have accelerated the loss of genetic diversity and reductions in population size of native species that are already threatened by population and genetic diversity decline. Fertile hybrids that are common among waterfowl (order Anseriformes) are especially worrisome. A prime example is the endangered Hawaiian duck (Anas wyvilliana; “koloa maoli”), which is the remaining endemic duck species on the main Hawaiian Islands and is threatened by genetic extinction through ongoing hybridization with feral mallards (Anas platyrhynchos). Of note, koloa populations are known to be strongly male-biased (3:1), and this sex bias is known to …

Prelimbic Cortex Neuronal Assemblies In Behaviors Predictive Of Drug-Seeking Before And After Cocaine Self-Administration, Karla J. Galvan

Open Access Theses & Dissertations

Literature has established that there are certain behaviors that are predictive of drug seeking and relapse such as impulsivity, distress tolerance (DT), Pavlovian conditioned approach (PCA), anxiety, and sensation-seeking. However, few studies have examined the behavioral interactions among these tasks and drug-seeking, and none have examined the neural interactions in the prelimbic cortex, which has an essential role in drug-seeking and is implicated in each of the aforementioned behaviors of interest.We therefore hypothesized that certain behaviors including high impulsivity, low distress tolerance, high anxiety, and high locomotor activity would predict high cocaine-seeking. We further hypothesized that the neuronal activity in …

Bilingual Comprehension Of Accented Speech And Spoken Code Switches, Liam John Gleason

Open Access Theses & Dissertations

Across three experiments, the current study explored how accented speech and coarticulation impact how bilingual listeners comprehend code-switches in speech. Eye-tracking methodology was used to compare responses to single-language and code-switched sentences. Experiment 1 observed how accented speech influenced the costs involved in comprehending code-switches by comparing responses to speakers that had North American English accents to speakers with Juarez/El Paso Spanish accents when speaking English. Experiment 2 compared responses to English speech produced by speakers with North American English, Flemish, and Bulgarian accented speakers. To examine coarticulation as a cue to an upcoming code-switch, Experiment 3 compared naturally produced …

Assessing Nordihydroguaiaretic Acid Properties And Its Potential Therapeutic Effect For Glioblastoma, Jose Arturo Guerrero

Open Access Theses & Dissertations

This study employs a combination of theoretical and experimental analysis to spectroscopically investigate the biomechanistic structure relationship and therapeutic effects of the Nordihydroguaiaretic Acid (NDGA) chemical derived from the Larrea Tridentata plant. These relationships are crucial for understanding NDGA's efficacy in disease prevention, treatment, and potential toxicological effects. While the medicinal and antiviral properties of the NDGA have been studied extensively, there remains a gap in optically identifying and reporting its structural changes. The current research successfully reveals evident trends in NDGA's vibrational signatures, particularly highlighting the absence of the Raman feature at 780 〖cm〗^(-1) as indicative of a fully …

Local Map Of The Interstellar Fuv Field, David Lomeli

Open Access Theses & Dissertations

The strength of the far-ultraviolet field is an important parameter in determining the chemistry that takes place in star-forming regions. FUV radiation is produced by bright stars in the galaxy and absorbed by interstellar dust. By using newly available maps of the dust distribution, in conjunction with catalogs of stellar positions and spectra, we created a local map of the FUV field ranging from 6-13.6 eV. We find a value of 6.57*10^-14 erg/cm^3 at the location of the Sun. This value, alongside its spectra, follow previous measurements and estimates of the FUV field at the Sun. We further study the …

My Little Poetic/Prose Book Of Words, Sayings, And Stories In Broken Spanish And A Little Bit Of German / Mi Libro Chiquito De Poética / Prosa De Palabras, Dichos, Y Historias Español Fracturado Y Un Poquetito Alemán, Sharon Ann Lucero

Open Access Theses & Dissertations

Acknowledgements

First and foremost, I would like to thank Jonathan Taylor and Sarah Thompson for the wonderful job they did in providing me with feedback. I took into consideration all their comments. Their comments aligned with Dr. Powers, and I really took a deeper look into my Spanish/English translations on whether I should have them or not. I found a happy medium for all of it. I also went back and looked at the rest of the class’s comments and made sure that I did not miss any of the details that were pointed out to me the first time …

Computational Study Of Fluorescent Molecular Probes For The Early Detection Of Alzheimer's Disease, Gabriela Elizabeth Molina Aguirre

Open Access Theses & Dissertations

Alzheimer's disease is a debilitating brain disorder that affects memory, thinking, and behavior. It is the most prevalent form of dementia and the seventh leading cause of death in the United States. As, researchers have identified biomarkers that can indicate the presence of the disease many years before the first symptoms appear, so there is an opportunity for early detection and treatment follow-ups, which could significantly improve the quality of life for those affected by this disease.This dissertation investigates the relationship between molecular structure and optical properties of donor-bridge-acceptor (DBA) fluorescent molecular probes designed for detecting Amyloid-β and p-Tau protein …

Analysis Of Drying Behavior Of Robocasted Barium Titanate, Abigail Ortega

Open Access Theses & Dissertations

Finding an adequate ceramic formulation for material extrusion is a time-consuming process. The necessary equipment may be unavailable to perform the desired test. This study demonstrated an alternative to observe a material after extrusion to understand its drying process. This study focused on 55 solid loading volume percent and a 39 solid loading volume percent, each with two different binder treatments focusing on fresh same day made binder, a 30 day old, aged binder and lastly an artificial binder obtained by a fuming process. Firstly, a formulation was created and loaded onto a pressure-based syringe to be extruded with a …

Building Positive Gender Expressions Among Mexican-American College Students, Nezahualcóyotl Paniagua-Jiménez

Open Access Theses & Dissertations

This thesis explores the need for college programs to nurture and support positive gender expressions among Mexican-American college students. It does so through a historical and cultural analysis of gender identities and expressions within the Mexican community and how they impact the lives of Mexican-American college students. Additionally, it offers an exploration of potential practices and programs that support the development of positive identity and gender expressions, with a lens of intersectionality, to ensure students are allowed to critically explore and develop gender identities that move away from domination/subservience power structures and that are founded on their unique cultural background.

Establishing The Validity Of A Measure Of Implicit Bias Toward People With Alcohol Use Disorder, Erin Marie Portillo

Open Access Theses & Dissertations

Alcohol use disorder has been identified as one of the major burdens of disease but also remains one of the disorders with the lowest treatment prevalence. For individuals who seek treatment for their alcohol use disorder, they may experience barriers that impact their treatment for alcohol use disorder. These barriers may extend to a person’s beliefs, attitudes, and stigma. While attitudes and beliefs refer to their perceived need for treatment and beliefs of self-reliance, stigma is multistep process that makes way for stereotypes, prejudice, and acts of discrimination to take place. With labels such as “alcoholic” implying negative connotation and …

Characterizing The Mentoring Landscape In An Online Biology Cure: An Examination Of Student And Graduate Teaching Assistant Perspectives And Outcomes, Karen Alejandra Santillan

Open Access Theses & Dissertations

Both undergraduate research experiences (UREs) and course-based undergraduate research experiences (CUREs) provide students with benefits and opportunities such as improving technical skills and making connections that provide resources. Where these two experiences differ is accessibility. Similar to their URE counterpart, CUREs entail mentorship on the part of the faculty/graduate teaching assistant (GTA) instructor (Dolan, 2016). There is general agreement that mentoring has many benefits for undergraduate STEM students, such as an improvement in retention rates, increased confidence and self-efficacy, and a more established sense of belonging and science identity (Dolan, 2016). CURE instructors often adopt the role of “mentor” in …

Physics-Guided Scan Paths Optimization For Controlled Microstructure In Laser Powder Bed Fusion, Augustine Twumasi

Open Access Theses & Dissertations

Laser Powder Bed Fusion (L-PBF) is a renowned additive manufacturing technique, celebrated for its capability to construct intricate metal components with remarkable precision. However, one of the main challenges with L-PBF is the formation of complex microstructures, which can significantly impact the final material properties. To address this issue, our study proposes a physics-guided and machine-learning-aided approach to optimize scan paths for achieving desired microstructure outcomes, such as the generation of equiaxed grains that enhance material properties. By using phase-field modeling, a physics-based computational method, we gain insights into microstructure evolution. To reduce computational costs, we train a surrogate machine-learning …

Automated Composition Of Multivariable Scientific Workflows Considering Scientific Assumptions, Raul Alejandro Vargas Acosta

Open Access Theses & Dissertations

Many ground-breaking scientific experiments require the execution of multiple complex scientific computations. Thus, scientific workflows (i.e., a sequence of scientific computations) have received significant attention, more specifically, the automated composition of scientific workflows. Scientific workflows that repurpose data may have unique scientific assumptions that need to be considered when composing a workflow. Workflow composition tools have enabled a wider range of stakeholders (e.g., policymakers, the general public, and researchers) to create and execute workflows; however, domain expertise is still required for these tasks. The overarching goal of this work is to further improve the automatic composition of scientific workflows by …

Will Consumer-Generated Reviews And Electronic Word-Of-Mouth Communications Affect Subjective Norm Perceptions, Attitudes Toward Social Commerce, And Social Shopping Intensions Among Gen Z Consumers?, Adebusola Azeezat Adewale

Open Access Theses & Dissertations

Social commerce has become a global phenomenon in recent years. Its convenience and accessibility have revolutionized how consumers shop and interact with brands and merchants. Gen Z consumers make up the majority (55.5%) of social buyers, and they are likely to be influenced by consumer-generated reviews (CGRs) and electronic word-of-mouth (eWOM) on social media. This thesis draws on the Theory of Planned Behavior (TPB) and employs a quantitative online questionnaire to determine whether CGRs and eWOM influence subjective norms (SN) perceptions, attitudes toward social commerce (ASC), and social shopping intention (SSI) of Gen Z consumers. The theoretical framework also included …

Fighting For A Health Diagnosis: An Autoethnographic Journey Into The Role Of Access And Limitations Of Resilience In The Face Of Poverty, Josette Pelatan

Open Access Theses & Dissertations

This research represents a highly personalized account of the complexities, interpretations, and reflections of the journey of a doctoral student navigating the challenges of health through access on a U.S.-Mexico border. Using myself as the subject and the researcher in the social context of schooling provided the impetus for this self-study. Through an insider’s vantage point, I have chronicled and traced the experiences of my own identities’ transitions and multilayered intersectionality using the qualitative methodology of autoethnography. This genre of qualitative research brings the reader closer to the subculture studied through the author’s experiences.

While every story has its unique …

Mapping Genotypes To Chromatin Accessibility Profiles In Single Cells, Franco Izzo, Robert M Myers, Saravanan Ganesan, Levan Mekerishvili, Sanjay Kottapalli, Tamara Prieto, Elliot O Eton, Theo Botella, Andrew J Dunbar, Robert L Bowman, Jesus Sotelo, Catherine Potenski, Eleni P Mimitou, Maximilian Stahl, Sebastian El Ghaity-Beckley, Joann Arandela, Ramya Raviram, Daniel C Choi, Ronald Hoffman, Ronan Chaligné, Omar Abdel-Wahab, Peter Smibert, Irene M Ghobrial, Joseph M Scandura, Bridget Marcellino, Ross L Levine, Dan A Landau

Faculty, Staff and Student Publications

In somatic tissue differentiation, chromatin accessibility changes govern priming and precursor commitment towards cellular fates1-3. Therefore, somatic mutations are likely to alter chromatin accessibility patterns, as they disrupt differentiation topologies leading to abnormal clonal outgrowth. However, defining the impact of somatic mutations on the epigenome in human samples is challenging due to admixed mutated and wild-type cells. Here, to chart how somatic mutations disrupt epigenetic landscapes in human clonal outgrowths, we developed genotyping of targeted loci with single-cell chromatin accessibility (GoT-ChA). This high-throughput platform links genotypes to chromatin accessibility at single-cell resolution across thousands of cells within a single assay. …

Automated, High-Throughput Platform To Generate A High-Reliability, Comprehensive Rectal Cancer Database, Neal Bhutiani, Mahmoud M G Yousef, Abdelrahman Yousef, Mohammad Zeineddine, Mark Knafl, Olivia Ratliff, Uditha P Fernando, Anastasia Turin, Fadl A Zeineddine, Jeff Jin, Kristin Alfaro-Munoz, Drew Goldstein, George J Chang, Scott Kopetz, John Paul Shen, Abhineet Uppal

Faculty, Staff and Student Publications

Purpose: Dynamic operations platforms allow for cross-platform data extraction, integration, and analysis, although application of these platforms to large-scale oncology enterprises has not been described. This study presents a pipeline for automated, high-fidelity extraction, integration, and validation of cross-platform oncology data in patients undergoing treatment for rectal cancer at a single, high-volume institution.

Methods: A dynamic operations platform was used to identify patients with rectal cancer treated at MD Anderson Cancer Center between 2016 and 2022 who had magnetic resonance imaging (MRI) imaging and preoperative treatment details available in the electronic health record (EHR). Demographic, clinicopathologic, tumor mutation, radiographic, and …

Genomic Landscape Of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens For Immunoprevention, Ana M Bolivar, Fahriye Duzagac, Nan Deng, Laura Reyes-Uribe, Kyle Chang, Wenhui Wu, Charles M Bowen, Melissa W Taggart, Selvi Thirumurthi, Patrick M Lynch, Y Nancy You, Jesus Rodriguez-Pascual, Steven M Lipkin, Scott Kopetz, Paul Scheet, Gregory A Lizee, Alexandre Reuben, Krishna M Sinha, Eduardo Vilar

Faculty, Staff and Student Publications

Background & aims: Lynch syndrome (LS) carriers develop mismatch repair-deficient neoplasia with high neoantigen (neoAg) rates. No detailed information on targetable neoAgs from LS precancers exists, which is crucial for vaccine development and immune-interception strategies. We report a focused somatic mutation and frameshift-neoAg landscape of microsatellite loci from colorectal polyps without malignant potential (PWOMP), precancers, and early-stage cancers in LS carriers.

Methods: We generated paired whole-exome and transcriptomic sequencing data from 8 colorectal PWOMP, 41 precancers, 8 advanced precancers, and 12 early-stage cancers of 43 LS carriers. A computational pipeline was developed to predict, rank, and prioritize the top 100 …

Transfer-Learning-Enhanced Regression Generative Adversarial Networks For Optimal Evtol Takeoff Trajectory Prediction, Shuan Tai Yeh, Xiaosong Du

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Electric vertical takeoff and landing (eVTOL) aircraft represent a crucial aviation technology to transform future transportation systems. The unique characteristics of eVTOL aircraft include reduced noise, low pollutant emission, efficient operating cost, and flexible maneuverability, which in the meantime pose critical challenges to advanced power retention techniques. Thus, optimal takeoff trajectory design is essential due to immense power demands during eVTOL takeoffs. Conventional design optimizations, however, adopt high-fidelity simulation models in an iterative manner resulting in a computationally intensive mechanism. In this work, we implement a surrogate-enabled inverse mapping optimization architecture, i.e., directly predicting optimal designs from design requirements (including …

Conversion Of Microcrystalline Cellulose To Hexane Using Hydrogenated Metal Oxides At Low Temperature And Pressure, Mubarak Osman

Electronic Theses and Dissertations

Increasing global energy demand and environmental concerns have fueled the exploration of sustainable and efficient methods for renewable fuel production. The conversion of cellulosic waste to hydrocarbon fuels using hydrogenated metal oxides presents a novel and eco-friendly approach to sustainably address energy demand. In this study, hydrogenated metal oxides were used as catalysts in a relatively low-temperature and atmospheric-pressure environment to facilitate the conversion of cellulosic waste into hydrocarbon fuels. Hydrogenated metal oxides have been introduced as potential hydrogen transfer catalysts. The expected result is the selective conversion of cellulose to hexane at relatively low temperatures, which significantly reduces energy …

The Role Of The Speech-Language Pathologist With Survivors Of Traumatic Brain Injury From Intimate Partner Violence And Providers’ Knowledge Of This Role, Nicolle Mcadams

Electronic Theses and Dissertations

Intimate partner violence occurs globally at alarming rates. Many experience adverse health impacts such as traumatic brain injury. Healthcare providers do not know the role of the speech-language pathologist, or the rehabilitation needs of survivors.

Aims: This scoping review aims to identify speech-language pathology services for survivors of intimate partner violence with a resulting traumatic brain injury, and knowledge of healthcare providers on the rehabilitation needs of this population. A search was completed in May to October 2023, resulting in a total of 13 articles reviewed.

Main contributions: Speech-language pathologists lack knowledge to provide services to intimate partner violence survivors …

Beyond The Screen: Understanding College Students’ Perspectives On Cyberstalking, Gabrielle Jackson

Electronic Theses and Dissertations

Previous research regarding the victimization of college students is primarily geared toward physical or sexual encounters. There is a limited scope of research regarding the online victimization of college students, specifically those involved in Greek life organizations. Furthermore, there is a misinterpretation of the definition of cyberstalking among college students, as many students are unaware that they have been personally victimized (Cass, 2011). This study seeks to examine college students’ perceptions of online victimization and how they may vary. The different student impressions and the prevalence of online victimization were examined using self-reported data from students enrolled in a university …