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Teacher Language Ideologies Concerning The Reclassification Of Emergent Bilingual Students: Navigating The Levels Of Power In Reclassification, Claudia Cabrera May 2024

Teacher Language Ideologies Concerning The Reclassification Of Emergent Bilingual Students: Navigating The Levels Of Power In Reclassification, Claudia Cabrera

Open Access Theses & Dissertations

Reclassification is a crucial educational student outcome when a school system determines that a student is English proficient and ready for mainstream instruction without language support services (Umansky et al., 2020). This study examined the relationship between crucial and complex language ideologies of dual language teachers and the reclassification of emergent bilingual students1.. Language ideologies were the theoretical framework for the study through which the voices of dual language teachers were captured. The analysis of data sources, including teacher interviews, classroom observations and evidence of biliteracy development, helped to understand and reveal how dual language teachers navigate the dynamics of …


Examining The Effects Of Acute And Chronic Stress On The Interrogative Suggestibility Of Young Adults, Claudia Cota May 2024

Examining The Effects Of Acute And Chronic Stress On The Interrogative Suggestibility Of Young Adults, Claudia Cota

Open Access Theses & Dissertations

High-stress situations, like police interrogations, can hinder an individual's decision-making and critical-thinking ability (Liston et al., 2009), making them more susceptible to suggestive or leading messages during questioning. While research on suggestibility mainly focuses on children and adolescents, young adults may also be vulnerable to suggestion because of their sensitivity to social feedback (Blakemore & Mills, 2014; Redlich & Goodman, 2003). Since the legal consequences of suggestibility for young adults are more severe than for children or adolescents, it is essential to examine the role of stress in young adults' suggestibility. The present study used objective and subjective methods to …


Using Genetic Algorithm And Geographic Information System For Equity-Driven Transportation Planning And Analysis, Emiliano Del Rio Reyes May 2024

Using Genetic Algorithm And Geographic Information System For Equity-Driven Transportation Planning And Analysis, Emiliano Del Rio Reyes

Open Access Theses & Dissertations

Efforts to address equitable access in public transit planning have gained momentum, spurred by incentives for Metropolitan Planning Organizations (MPOs) and State Departments of Transportation (DOTs). However, traditional strategies often fall short of meeting the needs of disadvantaged communities, particularly in underserved areas. This study presents a pioneering methodology leveraging Genetic Algorithms (GA) and Geographic Information Systems (GIS) to optimize bus stop placement, aiming to enhance equitable access in public transit systems. Focusing on Route 16 of Sun Metro in El Paso, Texasâ??a critical feeder route linking the Westside Transit Center to Upper Valley neighborhoodsâ??the research commences with a comprehensive …


Exploring Peer Perspectives On Autistic Students: A Vignette Study, Justin Linville May 2024

Exploring Peer Perspectives On Autistic Students: A Vignette Study, Justin Linville

Electronic Theses and Dissertations

A 2x2 design was undertaken to determine the effects of vignette character gender and autism disclosure status on social distance scores, reading comprehension performance, and false memory induction. The introduction focuses on the theoretical threads taken from the autism, false memory, and gender literatures and how they combine to create the underpinning of the current design. A second more controlled study was compelled by initial false impressions of the deleterious effects of fast completion times. This second study resulted in lengthened completion times and improved vignette comprehension. Two-way MANOVAs with gender and autism disclosure serving as independent variables on the …


Engaging Students In Learning Music Theory Fundamentals And Preparing For College Level Music Theory, Marissa Aronson May 2024

Engaging Students In Learning Music Theory Fundamentals And Preparing For College Level Music Theory, Marissa Aronson

Electronic Theses and Dissertations

The goal of this thesis is to provide teachers resources to prepare students for college-level music theory by using the keyboard. By providing visualization of patterns, the keyboard provides a superior tool to create a smooth transition between pre-college and college-level music theory instruction. In search of easing the passage between these levels, I interviewed numerous piano teachers who provided suggestions on how they include the keyboard to teach theory. After the interviews, I compared piano lesson theory books and college theory textbooks to compare their approaches. To assist with any gaps found in the theory books, I provide some …


Formalization Of A Security Framework Design For A Health Prescription Assistant In An Internet Of Things System, Thomas Rolando Mellema May 2024

Formalization Of A Security Framework Design For A Health Prescription Assistant In An Internet Of Things System, Thomas Rolando Mellema

Electronic Theses and Dissertations

Security system design flaws will create greater risks and repercussions as the systems being secured further integrate into our daily life. One such application example is incorporating the powerful potential of the concept of the Internet of Things (IoT) into software services engineered for improving the practices of monitoring and prescribing effective healthcare to patients. A study was performed in this application area in order to specify a security system design for a Health Prescription Assistant (HPA) that operated with medical IoT (mIoT) devices in a healthcare environment. Although the efficiency of this system was measured, little was presented to …


Adding Parasite Resistance To A Hair Sheep Breeding Objective, Robert M. Forbes May 2024

Adding Parasite Resistance To A Hair Sheep Breeding Objective, Robert M. Forbes

Department of Animal Science: Dissertations, Theses, and Student Research

The United States Hair Sheep Index was designed to increase total weight of lamb weaned per ewe lambing (TW) using estimated breeding values (EBV) for direct (DWWT) and maternal (MWWT) weaning weight, and number of lambs born (NLB) and weaned (NLW), as selection criteria. Producers are interested in adding post-weaning fecal egg count EBV (PFEC), an indicator of parasite resistance, to the index to achieve genetic change in both TW and PFEC.

First, the effects of adding PFEC alongside TW to the breeding objective of indexes that used either phenotypes or EBV as selection criteria were studied. Since MWWT …


Feeding Dried Distillers' Grains With Solubles To Lactating Dairy Cattle: Whole Animal Energy Utilization And Manure Biogas Production, Grant Michael Fincham May 2024

Feeding Dried Distillers' Grains With Solubles To Lactating Dairy Cattle: Whole Animal Energy Utilization And Manure Biogas Production, Grant Michael Fincham

Department of Animal Science: Dissertations, Theses, and Student Research

When DDGS are fed to lactating dairy cattle, the observed response in energy supply, milk production, and methane production varies among studies. One potential reason for these observed discrepancies is the nature of the diet formulation itself. Furthermore, little research has been conducted to examine how dietary changes can affect dairy cattle manure composition and methane production in an anaerobic manure digester. In order to gain a better understanding of these topics, we conducted two experiments. The first experiment was conducted to test how the manipulation of lactating dairy cattle diets affects energy utilization, milk production, methane production, and manure …


Perceptions Of Applied Behavior Analysis Therapy On Children With Autism Spectrum Disorder Via Social Media, Kaitlyn Drilling May 2024

Perceptions Of Applied Behavior Analysis Therapy On Children With Autism Spectrum Disorder Via Social Media, Kaitlyn Drilling

Honors Thesis

The use of Applied Behavioral Analysis Therapy (ABA) on children with Autism Spectrum Disorder (ASD) is a controversial topic. Stakeholders have strong opinions, and the use of social media allows them to reach a bigger audience to share their perceptions. Stakeholders such as parents of children with ASD, adults with ASD who have been treated using ABA therapy, and ABA clinicians themselves may post on long-form social media such as Reddit or Facebook to ASD specific forums. These forums provide stakeholders with information, community, and support that they might not have otherwise. The perceptions of ABA on children with ASD …


The Effects Of Selected Demographic Factors On The Reading Achievement Of Middle School Students, Kendrea J. Bryant May 2024

The Effects Of Selected Demographic Factors On The Reading Achievement Of Middle School Students, Kendrea J. Bryant

Dissertations (2016-Present)

Middle school is one of the most important times during which students gain knowledge. However, a large proportion of adolescents have continued to complete middle school without mastering essential knowledge of, and skills in, vocabulary and reading comprehension. Adolescents who miss school in the 30–60 days leading up to high-stakes exams experience declines in their reading scores. The aim of this study was to examine the effects of selected demographic factors on the reading achievement scores and attendance of middle school students. Specifically, this study involved examination of the effects of socioeconomic status (SES), gender, and ethnicity—both separately and in …


Development And Pilot Testing Of A Surface Discrimination Test For People With Lower Limb Amputation, Colin Kruger, Kyle Mcknight, Sharlene Lim, Samuel Straus May 2024

Development And Pilot Testing Of A Surface Discrimination Test For People With Lower Limb Amputation, Colin Kruger, Kyle Mcknight, Sharlene Lim, Samuel Straus

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: There is a lack of understanding as to how sensory loss and sensory deficits impact those with LLA. The purpose of this research is to determine the extent to which people with LLA can discriminate between surfaces underfoot, in order to better understand the relationship between people with LLA and their perception of the ground they are walking on. We developed a test to determine which qualities of surfaces may be easier to distinguish.

Methods: 10 unimpaired adults and 2 adults with LLA participated. Participants compared surfaces underfoot that consisted of ceramic, rough tile, gravel, sand, and sandpaper to …


Barriers To A Real Second Chance: Seeking Redemption While Set Up For Failure, Kara Forrai May 2024

Barriers To A Real Second Chance: Seeking Redemption While Set Up For Failure, Kara Forrai

UNLV Theses, Dissertations, Professional Papers, and Capstones

With the enactment of the Second Chance Act in 2008, there has been a need to better understand the effectiveness of prisoner reentry programs and the services that are provided within these programs. Since then, numerous articles have described the barriers that previously incarcerated persons encounter during reentry and how this increases the likelihood of recidivism. The goal of this current study is to understand what current barriers exist for individuals within a local reentry program and then to suggest future implementations that could reduce the impact of these barriers. To achieve this goal, qualitative research methods are employed to …


Discerning Moral Injury, Alexandra A. Merletti May 2024

Discerning Moral Injury, Alexandra A. Merletti

UNLV Theses, Dissertations, Professional Papers, and Capstones

Moral injury is a recently developed psychological construct used to explain trauma that cannot be adequately explained by post-traumatic stress disorder (PTSD). It arises from experiences in which sufferers feel that they have violated deeply held moral beliefs and has multiple negative long term health and professional consequences for individuals affected. In order to better understand moral injury, this study seeks to understand how it is identified in individuals by others and utilizes Christie’s (2018) Ideal Victim Theory and Gray and Wegner’s (2009) Moral Typecasting Theory as a theoretical framework. Participants for this study were 374 undergraduate students at the …


Simulation And Design Of Ion Traps Using The Method Of Fundamental Solutions, Trevor Taylor May 2024

Simulation And Design Of Ion Traps Using The Method Of Fundamental Solutions, Trevor Taylor

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this thesis I apply the numeric method, the Method of Fundamental Solutions (MFS), to solve for the fields create by ion traps in various configurations, such as quadrupole ion traps, linear ion traps, toroidal ion traps, and toroidal surface ion traps. The traps are then designed to maximize desired qualities such as minimization of their anharmonicity, and their ability to shuttle ions. A particular focus will be on the toroidal surface ion trap, as well as its ability to shuttle ions. This trap is planned for future experiments involving measurement of the electron Electric Dipole Moment.


Raise The Dead, Kendall Cruise May 2024

Raise The Dead, Kendall Cruise

Gandy Dancer Archives

No abstract provided.


Gandy Dancer 12.2, Gandy Dancer May 2024

Gandy Dancer 12.2, Gandy Dancer

Gandy Dancer Archives

Gandy Dancer is a literary magazine, publishing fiction, poetry, creative nonfiction, and visual art. We invite submissions from student writers and artists at all of the SUNY campuses. Edited by students at SUNY Geneseo, Gandy Dancer is published twice yearly. For more information, visit www.gandydancer.org. Gandy Dancer 12.2 is the twenty-third issue, published Spring 2024.


Lincoln's Carnegie Library: A History Of Community And Philanthropy, Emily Blomstedt May 2024

Lincoln's Carnegie Library: A History Of Community And Philanthropy, Emily Blomstedt

Honors Program: Senior Projects (Public)

Nebraska received 69 Carnegie libraries from the Carnegie foundation between 1899 and 1922. The first and most expensive Nebraska Carnegie library was granted to Lincoln in December 1899, after a fire destroyed Lincoln’s previous library. Lincoln’s main Carnegie library served the community between 1902 and 1960 before it was torn down in 1961 to build the present-day Bennett Martin library. This thesis explores the 60-year history of Lincoln’s Carnegie library, how it connects to national trends surrounding Carnegie libraries, and the role community and philanthropy played in the development of Lincoln’s public library system. These themes are examined through a …


Lululemon Strategic Audit, Tessa Mozingo, Olivia Eno, Molly Mitchell, Connor Morrissey, James Eshleman May 2024

Lululemon Strategic Audit, Tessa Mozingo, Olivia Eno, Molly Mitchell, Connor Morrissey, James Eshleman

Honors Program: Senior Projects (Public)

This case study focuses on lululemon, a prominent athleisure apparel company. Our team conducted an audit of the company revolving around strategic business management principles. Our research used publicly available information that included the company’s website, SEC filings, news articles, lululemon’s annual reports, financial statements, IBIS industry reports, and online sources. The goal of this strategic audit is to develop an understanding of lululemon’s business activities and strategies, collect and analyze both internal and external data, and evaluate lululemon based on strategic management concepts.

In this strategic audit, we conduct internal, external, performance, and competitive analyses and an examination of …


Immune Cell Pair Ratio Captured By Imaging Mass Cytometry Has Superior Predictive Value For Prognosis Of Non-Small Cell Lung Cancer Than Cell Fraction And Density, Jian-Rong Li, Chao Cheng May 2024

Immune Cell Pair Ratio Captured By Imaging Mass Cytometry Has Superior Predictive Value For Prognosis Of Non-Small Cell Lung Cancer Than Cell Fraction And Density, Jian-Rong Li, Chao Cheng

Faculty, Staff and Students Publications

No abstract provided.


New York City Corporation Counsel Sylvia O. Hinds-Radix Named Keynote Speaker At New York Law School’S 132nd Commencement, New York Law School May 2024

New York City Corporation Counsel Sylvia O. Hinds-Radix Named Keynote Speaker At New York Law School’S 132nd Commencement, New York Law School

NYLS Community News

No abstract provided.


Filling In The Gaps: A Service Ecosystem Perspective On Purchase Groups As Interstitial Markets, Aditya Gupta, Sheila Roy, Renuka Kamath May 2024

Filling In The Gaps: A Service Ecosystem Perspective On Purchase Groups As Interstitial Markets, Aditya Gupta, Sheila Roy, Renuka Kamath

Faculty Publications – Marketing

Purpose

Given the continuing need to study service marketing adaptations that emerged in the wake of Covid-19, this paper looks at the formation and evolution of purchase groups (PGs) that arose in Indian gated communities during the pandemic and have continued functioning in the post-pandemic marketplace. Not only did these groups act as much-needed interstitial markets during a time of significant external disruption, but they also served as sites of value co-creation with consumers collaborating with each other and with service providers.

Methodology

Using a phenomenological research approach, we conduct 22 in-depth interviews with Indian consumers and small service providers …


Critical Risk Assessment, Diagnosis, And Survival Analysis Of Breast Cancer, Shamiha Binta Manir, Priya Deshpande May 2024

Critical Risk Assessment, Diagnosis, And Survival Analysis Of Breast Cancer, Shamiha Binta Manir, Priya Deshpande

Electrical and Computer Engineering Faculty Research and Publications

Breast cancer is the most prevalent type of cancer in women. Risk factor assessment can aid in directing counseling regarding risk reduction and breast cancer surveillance. This research aims to (1) investigate the relationship between various risk factors and breast cancer incidence using the BCSC (Breast Cancer Surveillance Consortium) Risk Factor Dataset and create a prediction model for assessing the risk of developing breast cancer; (2) diagnose breast cancer using the Breast Cancer Wisconsin diagnostic dataset; and (3) analyze breast cancer survivability using the SEER (Surveillance, Epidemiology, and End Results) Breast Cancer Dataset. Applying resampling techniques on the training dataset …


Texture-Based Classification To Overcome Uncertainty Between Covid-19 And Viral Pneumonia Using Machine Learning And Deep Learning Techniques, Omar Farghaly, Priya Deshpande May 2024

Texture-Based Classification To Overcome Uncertainty Between Covid-19 And Viral Pneumonia Using Machine Learning And Deep Learning Techniques, Omar Farghaly, Priya Deshpande

Electrical and Computer Engineering Faculty Research and Publications

The SARS-CoV-2 virus, responsible for COVID-19, often manifests symptoms akin to viral pneumonia, complicating early detection and potentially leading to severe COVID pneumonia and long-term effects. Particularly affecting young individuals, the elderly, and those with weakened immune systems, the accurate classification of COVID-19 poses challenges, especially with highly dimensional image data. Past studies have faced limitations due to simplistic algorithms and small, biased datasets, yielding inaccurate results. In response, our study introduces a novel classification model that integrates advanced texture feature extraction methods, including GLCM, GLDM, and wavelet transform, within a deep learning framework. This innovative approach enables the effective …


Virtual Scribes And Physician Time Spent On Electronic Health Records, Lisa Rotenstein, Edward R Melnick, Christine Iannaccone, Jianyi Zhang, Aqsa Mugal, Stuart R Lipsitz, Michael J Healey, Christopher Holland, Richard Snyder, Christine A Sinsky, David Ting, David W Bates May 2024

Virtual Scribes And Physician Time Spent On Electronic Health Records, Lisa Rotenstein, Edward R Melnick, Christine Iannaccone, Jianyi Zhang, Aqsa Mugal, Stuart R Lipsitz, Michael J Healey, Christopher Holland, Richard Snyder, Christine A Sinsky, David Ting, David W Bates

Faculty, Staff and Students Publications

Importance: Time on the electronic health record (EHR) is associated with burnout among physicians. Newer virtual scribe models, which enable support from either a real-time or asynchronous scribe, have the potential to reduce the burden of the EHR and EHR-related documentation.

Objective: To characterize the association of use of virtual scribes with changes in physicians' EHR time and note and order composition and to identify the physician, scribe, and scribe response factors associated with changes in EHR time upon virtual scribe use.

Design, setting, and participants: Retrospective, pre-post quality improvement study of 144 physicians across specialties who had used a …


Looking Beyond Mortality Prediction: Primary Care Physician Views Of Patients' Palliative Care Needs Predicted By A Machine Learning Tool, Lisa Rotenstein, Liqin Wang, Sophia N Zupanc, Akhila Penumarthy, John Laurentiev, Jan Lamey, Subrina Farah, Stuart Lipsitz, Nina Jain, David W Bates, Li Zhou, Joshua R Lakin May 2024

Looking Beyond Mortality Prediction: Primary Care Physician Views Of Patients' Palliative Care Needs Predicted By A Machine Learning Tool, Lisa Rotenstein, Liqin Wang, Sophia N Zupanc, Akhila Penumarthy, John Laurentiev, Jan Lamey, Subrina Farah, Stuart Lipsitz, Nina Jain, David W Bates, Li Zhou, Joshua R Lakin

Faculty, Staff and Students Publications

Objectives: To assess primary care physicians' (PCPs) perception of the need for serious illness conversations (SIC) or other palliative care interventions in patients flagged by a machine learning tool for high 1-year mortality risk.

Methods: We surveyed PCPs from four Brigham and Women's Hospital primary care practice sites. Multiple mortality prediction algorithms were ensembled to assess adult patients of these PCPs who were either enrolled in the hospital's integrated care management program or had one of several chronic conditions. The patients were classified as high or low risk of 1-year mortality. A blinded survey had PCPs evaluate these patients for …


The Effect Of Crime On Mental Health In South Africa, Magda Tsaneva, Lauren-Kate Laplante May 2024

The Effect Of Crime On Mental Health In South Africa, Magda Tsaneva, Lauren-Kate Laplante

Economics

This paper examines the impact of district-level crime rates in South Africa on individual depression symptoms. We use panel data from the National Income Dynamics Survey collected between 2008 and 2014 and estimate an individual fixed effects regression model, thus controlling for characteristics of the individual's environment that could affect crime and mental health. We find that an increase of one standard deviation in property (violent) crime is associated with a 7.2 (8.7) percentage point increase in the probability of depression symptoms. Analysis of potential mechanisms suggests that indirect exposure to crime likely affects mental health by increasing stress rather …


Piezo1 Regulates Meningeal Lymphatic Vessel Drainage And Alleviates Excessive Csf Accumulation, Dongwon Choi, Eunkyung Park, Joshua Choi, Renhao Lu, Jin Suh Yu, Chiyoon Kim, Luping Zhao, James Yu, Brandon Nakashima, Sunju Lee, Dhruv Singhal, Joshua P Scallan, Bin Zhou, Chester J Koh, Esak Lee, Young-Kwon Hong May 2024

Piezo1 Regulates Meningeal Lymphatic Vessel Drainage And Alleviates Excessive Csf Accumulation, Dongwon Choi, Eunkyung Park, Joshua Choi, Renhao Lu, Jin Suh Yu, Chiyoon Kim, Luping Zhao, James Yu, Brandon Nakashima, Sunju Lee, Dhruv Singhal, Joshua P Scallan, Bin Zhou, Chester J Koh, Esak Lee, Young-Kwon Hong

Faculty, Staff and Students Publications

Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment with the chemical agonist Yoda1 is sufficient to increase cerebrospinal fluid (CSF) outflow by improving lymphatic absorption and transport. The abnormal accumulation of CSF, which often leads to hydrocephalus and ventriculomegaly, currently lacks effective treatments. We discovered that meningeal lymphatics in mouse models of Down syndrome were incompletely developed and abnormally formed. Selective overexpression of …


Safety And Tolerability Of Online Adaptive High-Field Magnetic Resonance-Guided Radiotherapy, Jasmijn M Westerhoff, Lois A Daamen, John P Christodouleas, Erwin L A Blezer, Ananya Choudhury, Rosalyne L Westley, Beth A Erickson, Clifton D Fuller, Shaista Hafeez, Uulke A Van Der Heide, Martijn P W Intven, Anna M Kirby, Susan Lalondrelle, Bruce D Minsky, Stella Mook, Marlies E Nowee, Corrie A M Marijnen, Kristina M Orrling, Arjun Sahgal, Christopher J Schultz, Corinne Faivre-Finn, Robbert J H A Tersteeg, Alison C Tree, Chia-Lin Tseng, Tine Schytte, Dustin M Silk, Dave Eggert, Marco Luzzara, Jochem R N Van Der Voort Van Zyp, Helena M Verkooijen, William A Hall May 2024

Safety And Tolerability Of Online Adaptive High-Field Magnetic Resonance-Guided Radiotherapy, Jasmijn M Westerhoff, Lois A Daamen, John P Christodouleas, Erwin L A Blezer, Ananya Choudhury, Rosalyne L Westley, Beth A Erickson, Clifton D Fuller, Shaista Hafeez, Uulke A Van Der Heide, Martijn P W Intven, Anna M Kirby, Susan Lalondrelle, Bruce D Minsky, Stella Mook, Marlies E Nowee, Corrie A M Marijnen, Kristina M Orrling, Arjun Sahgal, Christopher J Schultz, Corinne Faivre-Finn, Robbert J H A Tersteeg, Alison C Tree, Chia-Lin Tseng, Tine Schytte, Dustin M Silk, Dave Eggert, Marco Luzzara, Jochem R N Van Der Voort Van Zyp, Helena M Verkooijen, William A Hall

Faculty, Staff and Student Publications

Importance: In 2018, the first online adaptive magnetic resonance (MR)-guided radiotherapy (MRgRT) system using a 1.5-T MR-equipped linear accelerator (1.5-T MR-Linac) was clinically introduced. This system enables online adaptive radiotherapy, in which the radiation plan is adapted to size and shape changes of targets at each treatment session based on daily MR-visualized anatomy.

Objective: To evaluate safety, tolerability, and technical feasibility of treatment with a 1.5-T MR-Linac, specifically focusing on the subset of patients treated with an online adaptive strategy (ie, the adapt-to-shape [ATS] approach).

Design, setting, and participants: This cohort study included adults with solid tumors treated with a …


Benefit Of Axicabtagene Ciloleucel Versus Chemoimmunotherapy In Older Patients And/Or Patients With Poor Ecog Performance Status With Relapsed Or Refractory Large B-Cell Lymphoma After 2 Or More Lines Of Prior Therapy, Matthew A Lunning, Hai-Lin Wang, Zhen-Huan Hu, Frederick L Locke, Tanya Siddiqi, Caron A Jacobson, Sairah Ahmed, David B Miklos, Yi Lin, Brian T Hill, Armin Ghobadi, Sattva S Neelapu, Jason Westin, Chrisopher Dieyi, Polly Field, Harry Miao, Shilpa A Shahani, Anik Patel, Clare Spooner, Christine Fu, David Muramoto, Hairong Xu, Marcelo C Pasquini May 2024

Benefit Of Axicabtagene Ciloleucel Versus Chemoimmunotherapy In Older Patients And/Or Patients With Poor Ecog Performance Status With Relapsed Or Refractory Large B-Cell Lymphoma After 2 Or More Lines Of Prior Therapy, Matthew A Lunning, Hai-Lin Wang, Zhen-Huan Hu, Frederick L Locke, Tanya Siddiqi, Caron A Jacobson, Sairah Ahmed, David B Miklos, Yi Lin, Brian T Hill, Armin Ghobadi, Sattva S Neelapu, Jason Westin, Chrisopher Dieyi, Polly Field, Harry Miao, Shilpa A Shahani, Anik Patel, Clare Spooner, Christine Fu, David Muramoto, Hairong Xu, Marcelo C Pasquini

Faculty, Staff and Student Publications

Axicabtagene ciloleucel (axi-cel) in trials has demonstrated favorable efficacy compared with historical controls after ≥2 lines of therapy for the treatment of relapsed or refractory (R/R) large B cell lymphoma (LBCL). Herein, we compared the real-world effectiveness of axi-cel with efficacy and effectiveness of chemoimmunotherapy (CIT) in patients aged ≥65 years and patients with Eastern Cooperative Oncology Group performance status (ECOG PS) of 2. A total of 1146 patients treated with commercial axi-cel for R/R LBCL with ≥2 lines of prior therapy were included from the Center for International Blood and Marrow Transplantation Research prospective observational study, and 469 patients …


Effect Of Delayed Cell Infusion In Patients With Large B-Cell Lymphoma Treated With Chimeric Antigen Receptor T-Cell Therapy, Andrew P Jallouk, Naishu Kui, Ryan Sun, Jason R Westin, Raphael E Steiner, Ranjit Nair, Loretta J Nastoupil, Luis E Fayad, Ajlan Al Zaki, Misha Hawkins, Sherry Adkins, Mansoor Noorani, Kaberi Das, Jared Henderson, Elizabeth J Shpall, Partow Kebriaei, Jeremy Ramdial, Christopher R Flowers, Sattva S Neelapu, Sairah Ahmed, Paolo Strati May 2024

Effect Of Delayed Cell Infusion In Patients With Large B-Cell Lymphoma Treated With Chimeric Antigen Receptor T-Cell Therapy, Andrew P Jallouk, Naishu Kui, Ryan Sun, Jason R Westin, Raphael E Steiner, Ranjit Nair, Loretta J Nastoupil, Luis E Fayad, Ajlan Al Zaki, Misha Hawkins, Sherry Adkins, Mansoor Noorani, Kaberi Das, Jared Henderson, Elizabeth J Shpall, Partow Kebriaei, Jeremy Ramdial, Christopher R Flowers, Sattva S Neelapu, Sairah Ahmed, Paolo Strati

Faculty, Staff and Student Publications

Complications occurring after lymphodepleting chemotherapy (LDC) may delay chimeric antigen receptor (CAR) T-cell infusion. The effect of these delays on clinical outcomes is unclear. We performed a retrospective analysis of 240 patients with relapsed/refractory large B-cell lymphoma treated with standard-of-care axicabtagene ciloleucel (axi-cel) and identified 40 patients (16.7%) who had delay in axi-cel infusion. Of these, 85% had delay due to infection. At time of LDC initiation, patients with delayed infusion had lower absolute neutrophil count (P=0.006), lower platelets (P=0.004), lower hemoglobin (P5 days (4.6 vs. 8.2 months; P=0.036), but not 1 day (5.7 vs. 8.2 months; P=0.238). Following propensity …