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Full-Text Articles in Entire DC Network
Empowering Audio Recording: Academic Supporting Views, Yoshihiko Ariizumi
Empowering Audio Recording: Academic Supporting Views, Yoshihiko Ariizumi
Learning, Teaching, & Researching Optimization
This paper aims to demonstrate, drawing on findings from cognitive science, educational psychology, and creativity research, the proposition that incorporating voice recording into daily intellectual production activities can substantially enhance individual intellectual productivity.
One of the greatest challenges facing contemporary knowledge workers and learners is the asymmetry between the difficulty of securing uninterrupted time for thinking, on the one hand, and the latent abundance of fragmented “half-released” time in daily life—during commutes, household chores, exercise, waiting, and the like—on the other. This study proposes a methodology for resolving this asymmetry through recording technology.
As the conceptual framework of the paper, …
The Concept 'Pollination' And Bee Pan-Trap Color And Uv Reflectance Determine The Taxonomic Compositions Of Bee Taxa Captures Across An Elevation Gradient And Seasons In The Jemez Mountains Of New Mexico, Esther A. Burton, Kelly B. Miller, Paul J. Watson, David C. Witherington, Steven Poe, David Lightfoot
The Concept 'Pollination' And Bee Pan-Trap Color And Uv Reflectance Determine The Taxonomic Compositions Of Bee Taxa Captures Across An Elevation Gradient And Seasons In The Jemez Mountains Of New Mexico, Esther A. Burton, Kelly B. Miller, Paul J. Watson, David C. Witherington, Steven Poe, David Lightfoot
Biology ETDs
This thesis examines the pollinator concept and tests how sampling methods shape bee communities. Chapter 1 provides a conceptual and philosophical analysis, arguing that pollination is a process and that pollinators are context-dependent functional roles rather than fixed taxonomic categories. It traces the concept’s development from natural history to ecological theory, introduces a dual-goal model separating plant reproduction from visitor foraging, and proposes a classification framework based on evidentiary certainty and pollination potential to resolve ambiguity in pollination research.
Chapter 2 applies these ideas empirically by evaluating how pan-trap color and ultraviolet (UV) reflectance influence bee assemblages across elevation and …
Investigating Changes In The Stable Isotopic Composition Of Juniperus Osteosperma Over 34,000 Years Of Climatic Shifts, Lisa S. Garcia
Investigating Changes In The Stable Isotopic Composition Of Juniperus Osteosperma Over 34,000 Years Of Climatic Shifts, Lisa S. Garcia
Biology ETDs
Isotopic compositions of plants from the past provides empirical evidence for paleoclimatic shifts and plants physiologically response. This study used Neotoma paleomiddens (fossilized debris piles) collected from Death Valley National Park, which contained preserved abundant plant materials. These middens range from modern to >35,000 years and capture different climatic events in Earth history. Employing Juniperus osteosperma (Utah Juniper) leaves found in middens, I investigated variation in carbon and nitrogen stable isotopic composition. To help interpret paleomidden results, we used modern field and herbaria samples of Juniperus from a spatial gradient stretching across their geographic range. Results showed δ 13C …
Continuous Polygenic Trait Evolution Under Brownian Motion With Gaussian Mixture Models, Mary S. Hopkins
Continuous Polygenic Trait Evolution Under Brownian Motion With Gaussian Mixture Models, Mary S. Hopkins
Mathematics & Statistics ETDs
Gaussian mixed-models (GMMs) show promise as a tool for modeling polygenic trait evolution for multiple taxa with established phylogenetic comparative methods (PCMs). When phenotypic traits are influenced by more than one gene, neither a gene tree nor a species tree may be completely adequate to model specific cross-taxa dependencies. In such cases common solutions include using trees inferred from concatenated DNA sequences [35, 95] and consensus gene trees [35]. The GMM-based model, first proposed by Jiang in 2017 [55] allows traits to evolve on more than one tree with distinct topologies. This approach provides a framework for trait evolutionary modeling …
Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri
Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri
Mathematics & Statistics ETDs
Bayesian methods provide a flexible framework for time-to-event analysis by incorporating prior information. The power prior offers a systematic way to borrow information from historical data. This approach is especially valuable in clinical research, where historical data can enhance inference in early-phase trials with limited sample sizes. This dissertation develops Bayesian approaches for two-arm survival studies using both closed-form and simulation-based methods. The closed-form inference is derived under exponential and Weibull survival models. Under the proportional hazards framework, the posterior is derived through a normal approximation to the log hazard ratio, allowing inference on the treatment effect when the variance …
Imperial Continuities Beneath A Post-Colonial Pretense: Uncovering The Economic Foundations And Covert Objectives Of Operation Ajax, Fatimah Waqas
Imperial Continuities Beneath A Post-Colonial Pretense: Uncovering The Economic Foundations And Covert Objectives Of Operation Ajax, Fatimah Waqas
Senior Theses
Economic self-determination, that is, the right of a state to protect its national resources and direct its own growth, remains a topic of contention and struggle for numerous countries in the Global South. These nations’ attempts at advancing their economic self-determination are often exploited and sabotaged by industrial Western powers, notably the United States, which frequently employs covert operations and media propaganda to disguise its economic and imperial pursuits in developing, resource-rich nations. The case of Iran during the early 1950s is especially exemplary, as the nationalization of oil under Prime Minister Mohammad Mossadegh presented a direct conflict with U.S. …
Sayyid Qutb: Political Philosophy And The Global Decline Of Jihadist Legitimacy, Jorge A. Ferrara
Sayyid Qutb: Political Philosophy And The Global Decline Of Jihadist Legitimacy, Jorge A. Ferrara
Senior Theses
Historically and culturally, the meaning behind political philosophies has been misappropriated to serve new ideological aims, and understanding how contexts have changed is essential to contemporary debates surrounding militant jihadist ideology. Sayyid Qutb, a political philosopher in Egypt during the mid-twentieth century, whose political philosophy, which sought moral, spiritual, and societal reform in Egypt under Gamal ‘Abd-Nasser’s regime, has been classified as the philosopher of Islamic terror. In this thesis, I argue that Sayyid Qutb’s political philosophy has been misappropriated into a politicized and militant jihad ideology through successive reinterpretations by militant jihadist leaders, and that this misappropriation is evidence …
A De-Dollarizing World: How Sanctions Catalyze De-Dollarizing Efforts In Russia And China, Karina S. Amaach
A De-Dollarizing World: How Sanctions Catalyze De-Dollarizing Efforts In Russia And China, Karina S. Amaach
Senior Theses
For nearly a century, the United States has occupied the title as the world’s leading superpower nation. Such power has granted the US great economic responsibility, particularly highlighting the dollar’s dominant role as the international reserve and trade currency. However, the rise of competing powers– most notably China and Russia– have posed great threats to this continued economic dominance of the United States. This thesis examines how U.S. economic sanctions– often described as America’s greatest financial tool– have inadvertently motivated de-dollarization efforts led by these two nations. Drawing on interdisciplinary scholarship in foreign affairs, international political economy, and intergovernmental financial …
Evangelical Influences On The Prevalence Of Homophobia In 21st Century Brazilian Politics, Griffin M. Bilello
Evangelical Influences On The Prevalence Of Homophobia In 21st Century Brazilian Politics, Griffin M. Bilello
Senior Theses
In recent decades, Brazil has seen a large influx of Evangelical identification among its population, and this religious group has become a prominent political group that has occupied different positions of power in government. This Evangelical prominence has led to the blocking of LGBTQ+ legislative protections, the protection of homophobic governmental policies, and the perpetuation of anti-LGBTQ+ rhetoric that has threatened the well-being of Brazil’s queer community. This thesis analyzes the social media presence of prominent political figures in Brazil to understand the ongoing discourse regarding homosexuality from different perspectives. Three representatives with varying influences and perspectives were chosen and …
Symbolists Beyond The Magic: Appropriation In The Art Of Elihu Vedder And Gustave Moreau, Rebecca B. Shalliker
Symbolists Beyond The Magic: Appropriation In The Art Of Elihu Vedder And Gustave Moreau, Rebecca B. Shalliker
Art & Art History ETDs
This thesis examines the paintings of Elihu Vedder and Gustave Moreau as examples of how the late nineteenth-century Symbolist movement drew on Eastern regions as aesthetic sources for representing the spiritual. Considering the iconographic and conceptual overlap with the Spiritualist movement, it explores how these groups contributed to constructing an image of the “East” as inherently mystical. While existing scholarship analyzes the Symbolist movement’s engagement with psychoanalytical concepts such as the subconscious and dream state, the role of cultural appropriation in shaping the Symbolist aesthetic has been largely overlooked.
The depiction of Eastern iconography as fantastical will be explored through …
From Body Positivity To Body Power: How Music Therapy And Body Liberation Intersect To Address Body Oppression In The Therapeutic Space–A Literature Review, Katherine M. Perkoski
From Body Positivity To Body Power: How Music Therapy And Body Liberation Intersect To Address Body Oppression In The Therapeutic Space–A Literature Review, Katherine M. Perkoski
Expressive Therapies Theses
With the rise of overt fascism, anti–fat bias, anti–intellectualism, anti–multiculturalism, anti–diversity, equity, and inclusion, and the persistence of white, capitalist, cisheteropatriarchy narratives around bodies, music therapists need to recognize how client and therapist bodies show up in practice. In this critical literature review, bodies will be sociopolitically and culturally contextualized, and the intersections of music therapy, body liberation, and body power will be discussed. Music therapists need to address the body oppression faced by sociopolitical identities such as race, gender, disability, age, body size, sexuality, neurodiversity, class, ethnicity, nationality, housing status, and immigration status. The music therapy field needs to …
Bridging The Gap - Integrating Dance/Movement Therapy (Dmt) Into Support Frameworks For Children With Developmental Coordination Disorder: A Literature Review, Anjelica R. Espinoza-Flores
Bridging The Gap - Integrating Dance/Movement Therapy (Dmt) Into Support Frameworks For Children With Developmental Coordination Disorder: A Literature Review, Anjelica R. Espinoza-Flores
Expressive Therapies Theses
Developmental Coordination Disorder (DCD) affects approximately 5% to 6% of school-age children globally. While the primary symptoms involve challenges with motor coordination, the impact often extends to a child’s social and emotional well-being, leading to increased anxiety and social isolation. Current interventions, such as occupational and physical therapy, focus largely on functional skill-building. However, these methods may not fully address the emotional and psychological experiences of the child. This thesis explores how Dance/Movement Therapy (DMT) can serve as a vital link between physical rehabilitation and emotional support. By examining research on neurobiology and therapeutic movement, this paper argues that DMT …
Shattering The Glass: Playmaking As A Therapeutic Intervention For Siblings Of Chronically Ill Children, To Counteract The ‘Glass Child’ Phenomenon: A Literature Review, Sarah Z. Ritter
Expressive Therapies Theses
This literature review investigates how a drama therapy-informed playmaking intervention process may support the healthy siblings (HS) of chronically ill children in processing and expressing their complex emotions. A review of the literature indicates that the HS often experience significant emotional and psychosocial impacts, including anxiety, sadness, anger, guilt, and feelings of neglect and isolation as their parent’s attention becomes focused on the ill child. Research emphasizes that a sibling's illness disrupts family roles, routines, and attachment dynamics and often positions siblings in caregiver roles, and distances them from their peers, where their needs are unintentionally minimized.
Expressive and narrative-based …
Implementing A Coatt Inspired Process To Support Adolescents And Young Adults With Neurodevelopmental Disorders In Transition: Development Of A Method, Andromeda Faber
Implementing A Coatt Inspired Process To Support Adolescents And Young Adults With Neurodevelopmental Disorders In Transition: Development Of A Method, Andromeda Faber
Expressive Therapies Theses
This capstone thesis project explored the use of a Coactive Therapeutic Theatre (CoATT) inspired process with folks who have neurodevelopmental disorders (NDDs) as they transitioned out of the high level of care at their therapeutic school into a lower level of care in college and the workforce. CoATT is a recovery-based model that is time bound as the step between a higher level of care and a lower level of care. This project culminated in a CoATT inspired transition-based process to meet the needs of the neurodiverse population. Themes that were identified from this method included joy, resilience, taboo, tolerating …
Exploring Expressive Arts Journaling For Older Adults In A Psychiatric Hospital Using Mindfulness, Self-Compassion And Open Studio, Lesley Rodriguez
Exploring Expressive Arts Journaling For Older Adults In A Psychiatric Hospital Using Mindfulness, Self-Compassion And Open Studio, Lesley Rodriguez
Expressive Therapies Theses
This thesis presents the findings of an expressive arts therapy group intervention for adults in a geriatric unit of a psychiatric hospital in the greater Boston area. The twice weekly, 6-week intervention aimed to explore the central question of what occurs when a method of expressive arts journaling is introduced to older adults for symptom management of anxiety and mood disorders during their hospital stay. Through arts-based research and participant feedback, this capstone thesis charts the group experiences. The MOSS Visual Journaling model is named after its domains; Mindfulness, Open-studio, Story-telling, and Self-compassion. Themes generated through thematic analysis of the …
Between Cultures: An Expressive Arts Community Engagement Project On Identity, Belonging, And Cultural Transition Among International Students, Shilpa Ivaturi
Between Cultures: An Expressive Arts Community Engagement Project On Identity, Belonging, And Cultural Transition Among International Students, Shilpa Ivaturi
Expressive Therapies Theses
International students navigating cultural transition often experience disruptions not only in social adjustment but also in their sense of identity, belonging, and meaning-making. Grounded in expressive arts therapy, cross-cultural psychology, and mythopoetic frameworks of transformation, this thesis explores how creative processes can support international students in reflecting on and integrating their evolving identities during periods of cultural transition. A four-hour trauma-informed expressive arts workshop, structured around the Hero’s Journey arc of departure, initiation, and return, was facilitated across two sessions at a university in the northeastern United States. Seven international students from diverse cultural backgrounds engaged in multimodal practices including …
From Regulation To Meaning-Making: An Integrative Literature Review Of Sensory Integration And Drama Therapy In Neurodiversity-Affirming Practice, Kerry Richmond
Expressive Therapies Theses
This integrative literature review examines the relationship between drama therapy core processes and sensory integration theory in supporting adolescents with neurodevelopmental differences. Existing literature indicates that sensory integration interventions support regulation and functional engagement, while drama therapy processes—embodiment, role, dramatic projection, and engagement with dramatic reality—facilitate relational interaction and expressive capacity. Grounded in neurodiversity, sensory integration, and drama therapy frameworks, this review situates sensory processing as a key component of regulation, social participation, and emotional development.
An integrative review methodology was used to synthesize interdisciplinary literature from occupational therapy, psychology, and drama therapy. Peer-reviewed sources were systematically identified, reviewed in …
Ecodramatherapy To Support Recovery From Religious And Spiritual Trauma, Ashton Eleazer
Ecodramatherapy To Support Recovery From Religious And Spiritual Trauma, Ashton Eleazer
Expressive Therapies Theses
Religious and spiritual (R/S) trauma is an often unrecognized form of complex trauma that results from religious beliefs, practices, or experiences that fracture survivors’ connection to the self, the body, meaning, safety, and community. An estimated 27-33% of U.S. adults are affected (Slade et al., 2023). R/S trauma shares features with complex PTSD and Developmental Trauma Disorder, but also includes moral injury, existential questioning, communal, and embodied shame. This literature review examines the potential of ecodramatherapy, a combined approach of drama therapy and ecotherapy, to support reconnection and recovery in survivors of R/S trauma. A targeted review of peer-reviewed literature …
Exploring Immigration-Related Trauma With Trauma-Informed, Culturally Relevant Creative Processes, Alexandra Gadway
Exploring Immigration-Related Trauma With Trauma-Informed, Culturally Relevant Creative Processes, Alexandra Gadway
Expressive Therapies Theses
The Latinx population is one of the fastest growing racial and ethnic groups in the United States, yet there is still a great need for culturally appropriate training tools and screenings to support folks experiencing immigration-related trauma. This study explores ways art therapy can foster connection and empowerment for a Latinx child impacted by immigration-related post-traumatic stress, if only the field considers expanding its culturally relevant and trauma-informed creative-based processes. Newer literature in trauma-informed expressive therapies suggests a bottom-up approach, wherein tapping into the kinesthetic and sensory levels of the Expressive Therapies Continuum (ETC) allows us to process through movement, …
From Worry To Invention: Developing The Lunch Bunch As A Multimodal Expressive Arts Model For Regulation, Collaboration, And Peer Connection In Elementary Schools, Pascale Lauren Mimran-Ugbabe
From Worry To Invention: Developing The Lunch Bunch As A Multimodal Expressive Arts Model For Regulation, Collaboration, And Peer Connection In Elementary Schools, Pascale Lauren Mimran-Ugbabe
Expressive Therapies Theses
This thesis documents the development of the Multimodal Expressive Arts Lunch Bunch, a small group intervention for elementary students delivered during the school lunch period at a public elementary school in Boston, Massachusetts. Grounded in multimodal expressive arts therapy, intermodal transfer theory, polyvagal-informed co-regulation, and principles of externalization, the intervention was designed as a low-barrier creative support group accessible regardless of diagnosis, referral status, or family pursuit of clinical services. Two cohorts of teacher-nominated students, one group of fourth-grade girls and one mixed-gender third-grade group, participated in a sequenced arc moving from worry externalization through collaborative invention, prototype construction, and …
Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez
Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez
Psychology ETDs
Fetal Alcohol Spectrum Disorders involve morphologic and neurobiological abnormalities in offspring subjected to prenatal alcohol exposure. Although not as well studied as high exposure, moderate prenatal alcohol exposure represents the most common and undetected form in humans. While learning and memory deficits have been well characterized at the behavioral level in humans with Fetal Alcohol Spectrum Disorders and in animal models of moderate prenatal alcohol exposure, few studies have determined the circuit or systems level mechanisms of the behavioral deficits. A complete understanding of the neural bases of memory deficits after moderate prenatal alcohol exposure is needed to ultimately identify …
The Pastoral Implications Of John Calvin's Genevan Psalter For Church Music Ministry In Hong Kong, Sze Man Symantha Leung
The Pastoral Implications Of John Calvin's Genevan Psalter For Church Music Ministry In Hong Kong, Sze Man Symantha Leung
Doctor of Pastoral Music Projects and Theses
The aim of this thesis is to interpret the pastoral meaning and function of Calvin’s Genevan Psalter and to illustrate how it can be applied to Hong Kong church music ministry today. Through the Genevan Psalter, Calvin advocates congregational and vernacular psalm‑singing in Reformed worship. He emphasizes piety, Scripture, congregational participation, and the shaping of daily spirituality beyond Sunday worship. The pastoral insights drawn from the use of the Genevan Psalter in Reformed worship offer five valuable implications for music ministry in Hong Kong today: Spirituality, Unity of the Church in Faith, Theological Education, Liturgical‑Musical Interrelationship, and Inclusiveness.
In addition …
Exemplars Of Faith: The Biblical Legacy Of Women In Chaplaincy, April M. Knoke
Exemplars Of Faith: The Biblical Legacy Of Women In Chaplaincy, April M. Knoke
Doctor of Ministry Projects and Theses
Abstract This dissertation argues that women in Scripture are not marginal figures but foundational to both the theological understanding and practical expression of chaplaincy. By integrating biblical exegesis, historical theology, socio-cultural analysis, womanist interpretation, and pastoral theology, the study identifies a consistent divine pattern of inclusion and empowerment. This pattern affirms the essential role of women in providing spiritual care within contemporary institutional settings.
Chapter 2 examines four Old Testament figures, Miriam, Deborah, Huldah, and Abigail, highlighting their leadership within patriarchal contexts through prophetic, judicial, diplomatic, and intercessory roles. Chapter 3 turns to the New Testament and explores the ministries …
The Church As Provider Of Pastoral Care: Relational Presence, Narrative Listening, Preaching, And Advocacy In African American Missionary Baptist Churches In Southside Fort Worth, Texas, Michael R. Timberlake
The Church As Provider Of Pastoral Care: Relational Presence, Narrative Listening, Preaching, And Advocacy In African American Missionary Baptist Churches In Southside Fort Worth, Texas, Michael R. Timberlake
Doctor of Ministry Projects and Theses
Abstract
Michael R. Timberlake, Sr.
May 1, 2026
THE CHURCH AS PROVIDER OF PASTORAL CARE: RELATIONAL PRESENCE, NARRATIVE LISTENING, PREACHING, AND ADVOCACY IN AFRICAN AMERICAN MISSIONARY BAPTIST CHURCHES IN SOUTHSIDE FORT WORTH, TEXAS
The purpose of this research project is to restore and maintain the resiliency in the African American Missionary Baptist churches in the Southside of Fort Worth, Texas. The research identified a high level of importance for African American churches in Fort Worth to resemble the historic legacy of spiritual leadership, communal care, and social advocacy while ministering within contexts marked by racial and economic marginalization. Enabling practical …
Essays On Development Economics, Environmental Economics, And Political Economy, Weihong Li
Essays On Development Economics, Environmental Economics, And Political Economy, Weihong Li
Economics Theses and Dissertations
Chapter 1 explores the strategic behavior of provincial leaders in China in response to visits by central government leaders. I find that such behavior is correlated with provincial leaders’ personal characteristics and their connections with the visitors. Meanwhile, acting strategically during these visits has a positive and significant effect on overall promotions, but a positive and insignificant effect on promotions to the most important positions in the Politburo.
Chapter 2 examines the impact of the Confucian norms on the spatial heterogeneity of fertility rates and sex-selective abortions in contemporary China. To overcome the challenge of quantifying cultural norms, I construct …
Predictive Natural Language Metrics Of Alzheimer's Disease And Cognitive Decline Trend Analysis, Zerui Ma
Predictive Natural Language Metrics Of Alzheimer's Disease And Cognitive Decline Trend Analysis, Zerui Ma
Computer Science and Engineering Theses and Dissertations
Inspired by Dr. David Snowden's Nun Study, which linked early-life Propositional Idea Density (PID) to later-life Alzheimer's disease, this thesis investigates two questions: whether fine-tuned Transformer-based large language models (LLM) can detect cognitive decline from patient speech transcripts with meaningful feature attribution, and whether longitudinal PID trends are observable across large-scale internet and academic text corpora. We evaluate dementia prediction on the DementiaBank Pitt Corpus and conduct an exploratory longitudinal PID analysis across seven diverse datasets spanning up to 29 years and over 12.6 million documents. This work suggests that linguistic ability metrics, traditional PID metrics and novel LLM-based analysis, …
Machine Learning And Formal Methods In Quantum Chemistry: Theory And Application, Ishna Satyarth
Machine Learning And Formal Methods In Quantum Chemistry: Theory And Application, Ishna Satyarth
Computer Science and Engineering Theses and Dissertations
In recent years, the progress in inter-disciplinary application of machine learning and artificial intelligence (ML/AI) have truly transformed various fields, from weather forecasting and drug development to medical diagnostics, energy, and sustainability. Computational chemistry uses computational tools to model, predict, analyze, and explain chemical phenomena, while the Quantum chemistry specifically uses techniques based on quantum mechanics (as opposed to classical mechanics or empirical models). Quantum chemistry or Computational chemistry has also observed a momentum in application of ML techniques over the past decade significantly accelerating results and providing valuable insights into vast datasets, often surpassing traditional methods.
This dissertation explores …
Advanced Finite Element Modeling And Design Enhancement Of Slender Square Concrete-Filled Double-Skin Steel Tubular Columns, Mahmoud T. Nawar, Ayman El-Zohairy, Mohamed Emara, Raghda I. Halima
Advanced Finite Element Modeling And Design Enhancement Of Slender Square Concrete-Filled Double-Skin Steel Tubular Columns, Mahmoud T. Nawar, Ayman El-Zohairy, Mohamed Emara, Raghda I. Halima
Faculty Publications
Limited research exists on the behavior of square CFDST slender columns, especially under the consideration of the relation global buckling and confinement effect. This study evaluates square concrete-filled double-skin steel tubular (CFDST) columns using nonlinear finite element analysis (FEA) to simulate structural behavior under axial and eccentric loads until failure. Parametric analyses of extensive specimens of square CFDST pinended columns evaluate various parameters, providing design insights for engineering applications. The study was conducted over a wide range of slenderness ratios. Four concrete varieties with compressive strengths were tested: normal concrete (NC), engineered cementitious composites (ECCs), high-strength concrete (HSC), and ultra-high-strength …
Characterizing A Potential Cbp/P300 Histone Acetyltransferase Homolog In Tardigrade Germline Specification And Development, Brittney Michelle Hartshorn
Characterizing A Potential Cbp/P300 Histone Acetyltransferase Homolog In Tardigrade Germline Specification And Development, Brittney Michelle Hartshorn
Honors Projects
Germline specification is a fundamental process that ensures the proper development of germ cells. Germline specification occurs either through germ cell determinants maternally inherited through the mechanism of preformation or through induction, where cell interaction and epigenetic modifications direct specification. Determining how these mechanisms evolved and diverged remains an important question in developmental biology. Despite research on germline regulation in model organisms such as Caenorhabditis elegans or Drosophila melanogaster, such regulation remains poorly understood in many other animal groups. Tardigrades are an emerging model system for investigating developmental mechanisms due to their phylogenetic placement and experimentally tractable embryos. CBP/P300 is …
Technical Advancements In Single-Molecule Spectroscopy For High-Throughput Measurement Of Long-Time Dynamics, Quyen B. Le
Technical Advancements In Single-Molecule Spectroscopy For High-Throughput Measurement Of Long-Time Dynamics, Quyen B. Le
Chemical and Biological Engineering ETDs
Single-molecule fluorescence spectroscopy is a powerful technique for resolving transient biomolecular dynamics and quantifying free energy landscapes, kinetics, and binding interactions. However, two fundamental limitations restrict its broader application: slow, labor-intensive data acquisition and the limited observation time imposed by fluorophore photobleaching. These limitations hinder its use in drug discovery and biomedical engineering applications that require both high-throughput and access to long-time dynamics. In this work, both challenges are addressed through technical advancements. First, a simple, generalizable approach is introduced to automate data acquisition, eliminating manual intervention during experiments. This increases the acquisition rate by more than an order of …