Digital Commons Network^™

Supporting Bibliodiversity And Access Through Library Resource Sharing, J. Silvia Cho

Publications and Research

Librarians, with their core values of access, intellectual freedom, stewardship and democracy, share bibliodiversity advocates’ vision of an eco-social system of diverse cultures and reading as a democratic and emancipatory practice. Librarians bolster bibliodiversity by collecting inclusively, critically reviewing and decolonizing library collections, and centering access. Building on previous discussions on the role of open access in strengthening bibliodiversity, this paper acknowledges and articulates how interlibrary loan and library resource sharing also support bibliodiversity. Doing so is important to augment advocacy and support for these services. Advancing solutions to challenges in resource sharing means also advancing towards bibliodiversity goals, supporting …

Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil

Faculty Research 2026

The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of therapeutics in Tg32 and Tg276 mice is essential to preclinical characterization. While Tg32 mice have been well established as indispensable in their ability to model the PK properties of antibody therapeutics, their intact immunity leaves them capable of mounting anti-drug antibody responses that interfere with PK interpretation. Here, we demonstrate the negative impact anti-drug responses can have on PK parameters derived from Tg32 mice, and provide strong evidence …

Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil

Faculty Research 2026

The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of therapeutics in Tg32 and Tg276 mice is essential to preclinical characterization. While Tg32 mice have been well established as indispensable in their ability to model the PK properties of antibody therapeutics, their intact immunity leaves them capable of mounting anti-drug antibody responses that interfere with PK interpretation. Here, we demonstrate the negative impact anti-drug responses can have on PK parameters derived from Tg32 mice, and provide strong evidence …

Using Randomization To Compare Ai And Expert-Generated Formative Assessment Questions In Medical Education, Akshat Kumar, Katie Stinson, Litao Wang, Elizabeth Nugent, Yongsu Lee, Mark Hormann, Latanya Jones Love, Toufeeq Ahmed Syed

Faculty, Staff and Student Publications

Background: AI-generated content is being used across the education spectrum and is beneficial for creating complex multiple-choice questions, such as those used in medical education. However, evaluating AI-generated content is challenging, and existing testing and evaluation methods are falling short. This study uses randomization to compare medical students' performance on and subjective evaluation of AI versus expert-generated questions. We hypothesized that there would be no difference in student performance or subjective evaluation of AI vs expert-generated questions.

Methods: We designed a single-center, randomized study where medical student participants received either one AI- or expert-generated question per day over four weeks. …

Toward Mapping Multiphase Multicomponent Mixtures With Neural Networks, Kristen L. Hallas, Melissa De Jesus, Christine J. Wu, Jianzhi Li, Jason Bernstein, Philip C. Myint

School of Mathematical & Statistical Sciences Faculty Publications

Equation of state (EOS) tables are commonly used in hydrodynamic simulations of high-pressure, high-temperature phenomena in fields like planetary science, astrophysics, and high-energy-density science. However, generating and storing EOS tables for multiphase, multicomponent mixtures over a wide range of pressures and temperatures is computationally infeasible due to their memory-intensive nature. To address this issue, we have developed a neural network-based machine learning model to predict new EOS tables for binary mixtures. In particular, a deep feedforward neural network trained on a set of ten EOS tables at particular mixture compositions is able to predict nine new (hold-out) EOS tables at …

Limosilactobacillus Reuteri Promotes Melatonin Release From Human Intestinal Organoids Via 5′Ectonucleotidase Activity, Micah D Forshee, Erika J Nachman, Esha R Shenoy, Heather A Danhof, Ludwig Ermann Lundberg, Stefan Roos, Robert A Britton

Faculty, Staff and Students Publications

Strains of Limosilactobacillus reuteri have been used to prevent or treat various conditions; however, the mechanisms by which they exert beneficial effects are not completely understood. Infant colic is one example in which L. reuteri DSM 17938 reduces clinical symptoms. While the etiology of colic is unknown, abnormal melatonin levels in infants have been suggested as a possible contributor. L. reuteri DSM 17938 has been shown to produce adenosine from AMP via production of the extracellular enzyme 5′ectonucleotidase (5′NT). Adenosine is a potent signaling molecule that impacts several important aspects of host physiology, including the release of melatonin from the …

Reducing The Detrimental Effects Of Post-Stroke Social Isolation Through Inhibition Of Mirna-10a-5p In A Mouse Model, Peijun Zhao

Summer Research Program Abstracts

No abstract provided.

Dysregulation Of Lipid Metabolism In Chronic Hypoxia In Neonates, Mason L. Wong

Summer Research Program Abstracts

No abstract provided.

The Impact Of Sex Hormones On Heritable Thoracic Aortic Disease: A Montalcino Aortic Consortium Study, Catherine E. Wilson

Summer Research Program Abstracts

No abstract provided.

Bacteriophage Encapsulation With Type A And Type B Gelatin Microparticles To Treat Antimicrobial-Resistant Orthopedic Device-Related Infections, Aiden A. Willis

Summer Research Program Abstracts

No abstract provided.

Leveraging Sports Analytics And Intraoperative Video To Improve Surgical Quality And Outcomes, Jasie L. Williams-Roberts

Summer Research Program Abstracts

No abstract provided.

Incidence And Risk Factors For Heterotopic Ossification After Acetabular Fracture Fixation Using A Kocher-Langenbeck Approach: A Single-Center Retrospective Cohort, Weston W. Wilber

Summer Research Program Abstracts

No abstract provided.

The Impact Of Narrative Interventions On Cognitive And Emotional Well-Being In Elders, Jasmine N. White

Summer Research Program Abstracts

No abstract provided.

A New Tool To Improve Prediction Of Clinical Outcomes After Endovascular Therapy For Patients With Large Infarct Core., Demi K. Waworuntu

Summer Research Program Abstracts

No abstract provided.

Sleep Respiratory Biomarkers Of Sudden Unexpected Death In Epilepsy (Sudep): A Case Control, Cat Tien Tran

Summer Research Program Abstracts

No abstract provided.

Age And Sex Modulation Of No Signaling In Mouse Brain, Emmaline R. Thorpe

Summer Research Program Abstracts

No abstract provided.

Reducing Acute Healthcare Services With Self-Management Of Blood Pressure Monitoring Through Remote Patient Monitoring For Hypertensive Patients A Quality Improvement Project, Becky J. Wagner

Doctor of Nursing Practice (DNP) Manuscripts

Hypertension (HTN) affects nearly half of U.S. adults and remains a leading cause of preventable emergency department (ED) visits, hospitalizations, and healthcare costs due to poor blood pressure (BP) control (Fryar et al., 2024; Mullins et al., 2019). Traditional care models often lack the continuous monitoring and timely intervention needed for effective chronic disease management. Remote Patient Monitoring (RPM) provides an innovative approach by delivering real-time BP data, enabling early clinical intervention, and encouraging patient engagement in self-management (Omboni et al., 2020).

This Doctor of Nursing Practice (DNP) project evaluated the effectiveness of an RPM intervention in reducing acute healthcare …

Is Your Cyst Really A Ganglion Cyst? A Case Report Of Angioleiomyoma Mimicking A Plantar Fascia Cystic Lesion, Christopher Anjorin Ms Dpmc, Joseph Bender Dpm

School of Podiatric Medicine - Student Research

Ganglion cysts are among the most common benign soft tissue masses encountered in podiatric clinical practice, and their diagnosis is often presumed based on location, clinical observation, and transillumination. However, this case highlights a diagnostic idiosyncrasy: a lesion clinically presumed to be a ganglion cyst within the plantar fascia was ultimately identified as an angioleiomyoma following surgical excision and histopathological evaluation. This finding underscores the importance of maintaining a broad differential diagnosis when assessing cystic lesions, particularly those that transilluminate, as benign vascular tumors may closely mimic more common entities in both clinical presentation and imaging. More importantly, what if …

Gauging Understanding Of Information In Discharge Education In Trauma And Burn Patients, Marissa N. Thibodeaux

Summer Research Program Abstracts

No abstract provided.

Improving Adherence To The Ticket-To-Test C. Difficile Protocol In A Medical-Surgical Microsystem, Georgette Marie D. Lim

Master's Projects and Capstones

Problem: Poor adherence to the ticket-to-test protocol on the 3 South unit led to unnecessary C. difficile testing, inappropriate isolation, and workflow variation. These issues mirror national concerns about over-testing and misdiagnosis, which can inflate hospital‑onset C. difficile rates and increase costs.

Context: This project was implemented on a medical‑surgical unit, a team with a strong culture of collaboration, education, and engagement in quality improvement. The unit benefits from structured oversight through the C. difficile committee, which reports to the performance improvement team.

Interventions: The Institute for Healthcare Improvement Model for Improvement guided four PDSA cycles, with …

Operating Room Waste Reduction In Watts And Water: Savings Beyond The Shift To Reusable Textiles, Taylor R. Sweeney

Summer Research Program Abstracts

No abstract provided.

Robust Statistical Methods For Microbiome Abundance Data, Yiming Shi

WUSM Theses and Dissertations – All Programs

Differential abundance analysis in microbiome studies aims to identify taxa whose abundance differs across biological or clinical conditions. The observed data are typically taxon-specific sequencing read counts, representing reads assigned to different taxa within each sample. These counts are indirect measurements of the underlying microbial abundance profile and are constrained by sample-specific library sizes. Microbiome count data are also typically sparse, overdispersed, and heteroscedastic. Together, these characteristics create substantial challenges for differential abundance analysis and make the results highly sensitive to normalization procedures, model specification, and the statistical methods used for inference.

Normalization defines the scale on which samples are …

Investigating The Ability Of Presequences To Influence Mitochondrial Protein Import, Youmian Yan

WUSM Theses and Dissertations – All Programs

Mitochondria are essential organelles housing over 1000 proteins, 99% of which are nuclear-encoded and synthesized in the cytosol. Most mitochondrial proteins are targeted by a positively charged sequence called the presequence, which lacks a common sequence motif and is poorly conserved across evolution. Accumulating evidence suggests that presequences encode meaningful information that influences mitochondrial protein uptake. For instance, multiple stress response models propose that stress sensing proteins contain “weak” presequences which allows them to monitor mitochondrial health. However, there is a lack of systematic examination about how presequences influence import kinetics and what constitutes presequence strength. These gaps in knowledge …

The Hemostatic Properties Of Green Plasma, David J. Sun

Summer Research Program Abstracts

No abstract provided.

Sar Ship Detection Based On Shallow Feature Guidance, Chenxu Xia, Peng Chen, Ya Zhang, Ying Li

Journal of Marine Science and Technology–Taiwan

Maritime ship detection is of great significance for both military security and civilian applications. Synthetic Aperture Radar (SAR), with its all-weather and all-day imaging capability, plays a vital role in maritime surveillance. Nevertheless, SAR ship targets typically appear small in scale, embedded in complex backgrounds, blurred at boundaries, and easily confused with near-shore features, which pose substantial challenges for accurate detection. To address these issues, we propose a SAR ship detection network that integrates dual enhancements of small-object representation and edge information. The network introduces two key components: the Small Target Refine Pyramid (STRP) to strengthen shallow feature representation for …

Enhancing Shipboard Safety Management Under The Ism Code: An Innovative Risk Assessment Framework With A Stern Tube Case Study, Pi-Yen Lin

Journal of Marine Science and Technology–Taiwan

The shipboard safety management system (SMS) is designed to enhance safe operations, risk management, and emergency response to improve overall ship safety and efficiency. This paper demonstrates the use of an engine room simulator (ERS) for collecting failure modes and applies it to a comprehensive failure analysis of the stern tube lubricating oil system. A new risk closeness coefficient method was developed, integrating expert background knowledge and weighted risk assessments. The analysis, based on multiple expert evaluations, covered five subsystems, eight main components, 23 failure modes, and 112 failure causes. This study presents 26 recommendations for maritime practitioners and onboard …

Improvements Upon Reprocessing Of Orthopedic Single-Use Instruments, Alyssa P. Nguyen

Master's Projects and Capstones

Internal Medline data for Hospital A, a level I academic trauma center, identified a quality gap due to improper segregation and underutilization of orthopedic single-use device reprocessing bins. The baseline reprocessing rate of 4% for orthopedic products results in missed sustainability opportunities, financial strain, and increased regulated waste. A proposed quality improvement intervention implemented updated communication strategies, visual management tools, and education modules to reinforce current reprocessing workflows and close knowledge gaps. Outcome measures include the percentage of SUDs collected for reprocessing, survey results on reprocessing awareness, and potential financial savings in Appendix I. Early data showed a 10% year-to-year …

Firms’ Darq Readiness And Marketing Implications: A Systematic Literature Review, Ali N. Tehrani, K. Roy, Richard Gruner

Research outputs 2022 to 2026

Purpose – This study aims to systematically review literature across diverse disciplines, including marketing, management and information systems, to synthesise insights on firms’ readiness to adopt and implement DARQ technologies and their marketing implications. DARQ technologies are emerging and cutting-edge technologies, including Distributed Ledger Technology, Artificial Intelligence, Extended Reality and Quantum Computing (hence, DARQ). Design/methodology/approach – Through a systematic review of over 2, 500 papers across three databases, this study distilled a focused sample of 88 papers. It comprehensively explores the reported dimensions, antecedents, outcomes and marketing implications of firms’ readiness for DARQ technologies. Findings – This study identified three …

Bridging The Gap: Assessing Barriers To Patch Testing Across Diverse Skin Tones, Ritesh V. Soule

Summer Research Program Abstracts

No abstract provided.

Knowledge, Attitudes, And Practices (Kap) Of Parents Regarding The Prevention And Control Of Childhood Iron Deficiency Anemia In Egypt: A Cross-Sectional Study, Omnia Soliman

Theses and Dissertations

Childhood Iron Deficiency Anemia (IDA) remains a major public health challenge in Egypt, where its persistently high and rising prevalence carries substantial consequences for child growth, cognitive development, immunity, and long-term health outcomes. Globally, approximately 40% of children aged 6–59 months are affected by anemia (World Health Organization, 2025), and Egypt mirrors this burden, with national data showing a worsening trend in recent years. In Egypt, national strategies have traditionally focused on biomedical interventions such as iron supplementation and food fortification, while less attention has been directed toward behavioral and household-level determinants, particularly parental knowledge, attitudes, and practices (KAP) related …