Digital Commons Network^™

Optimization, Characterization, And Comparison Of Two Luciferase-Expressing Mouse Glioblastoma Models, Louis Rodgers, Julia A. Schulz Pauly, Bryan J. Maloney, Anika M. S. Hartz, Bjoern Bauer

UK CARES Faculty Publications

Glioblastoma (GBM) is the most aggressive brain cancer. To model GBM in research, orthotopic brain tumor models, including syngeneic models like GL261 and genetically engineered mouse models like TRP, are used. In longitudinal studies, tumor growth and the treatment response are typically tracked with in vivo imaging, including bioluminescence imaging (BLI), which is quick, cost-effective, and easily quantifiable. However, BLI requires luciferase-tagged cells, and recent studies indicate that the luciferase gene can elicit an immune response, leading to tumor rejection and experimental variation. We sought to optimize the engraftment of two luciferase-expressing GBM models, GL261 Red-FLuc and TRP-mCherry-FLuc, showing differences …

Recovery Heros: Recruiting Recovery Coaches And Peer Support Specialists At The Coulee Recovery Center, Sascha S. Cromheecke

Strategic Communication Master of Arts Thesis Projects

No abstract provided.

A Parent's Guide To Social Media Safety, Catherine Grimley

Gator Team Child Juvenile Law Clinic

The goal of this White Paper is to provide parents and other caregivers with a compilation of literature from some of the most popular social media platforms in one convenient place. It aims to help parents understand what parental controls and account settings are available, so they can facilitate important conversations with their teens regarding social media safety.

Worldshare Record Manager: Cataloging With Wms, Ashley L. Smith

Library Presentations

WorldShare Record Manager is a cataloging tool provided through WorldShare Management Services (WMS). This presentation will primarily focus on creating original records, copy cataloging, and editing bibliographic records with WorldShare Record Manager. The aim of this presentation is to familiarize anyone involved with their institution’s cataloging with the cataloging components of WMS.

Promoting The Integration Of Direct-To-Consumer Genetic Testing Results Into Clinical Practice, Kanesha Glenn

All Dissertations

In recent years, individuals have become interested in what insights direct-to-consumer genetic testing (DTCGT) can offer about their health. These individuals are recommended to discuss their concerns with a healthcare professional, yet most primary care professionals do not have a genetics-focused practice. This dissertation comprises five chapters to describe the integration of DTCGT results into a patient visit. Chapter I discusses the expanding demand between patients with questions about their DTCGT results and the health professionals who have been tasked to interpret these results. Chapter II is a systematic literature review that identifies what health professionals think about results from …

Visit The Imprisoned: A Heuristic Inquiry Into The Experiences Of Catholic Detention Ministry Volunteers, Christopher Tran

Education (PhD) Dissertations

There exists a wide breadth of literature in regards to the harmful and dehumanizing impact of incarceration on human development and dignity. Through my years as a volunteer in detention ministry, I have witnessed firsthand these effects particularly on youths who have been incarcerated. My experiences have led me to wonder then, “Why does the prison system still exist to harm people despite the array of research condemning its practices?” Through this pondering, I critiqued the larger systems at play: the prison-industrial complex, the sociopolitical rhetoric of “tough on crime,” and the overall demonization of this population. As a response …

Optimization Of Pre-Enrichment And Screening Methods For The Detection Of Salmonella Enterica In Meat Analog Products, Kylie Sacapano

Food Science (MS) Theses

With the growing demand and variety of meat analogs on the commercial market, there is a need to revisit the methodology for the detection of foodborne pathogens in these products. The current Food and Drug Administration (FDA) regulatory methods for Salmonella enterica detection in meat analogs follow the Bacteriological Analytical Manual (BAM) and are time-consuming and costly, requiring pre-enrichment using lactose broth (LB) with a surfactant (e.g., Triton X-100). Therefore, this study aimed to optimize pre-enrichment and screening methods for the detection of Salmonella in meat analogs by comparing the current FDA reference methods to updated techniques. To achieve this, …

A Meta-Analysis Of Seafood Species Mislabeling Rates In The United States, Sarah Ahles

Food Science (MS) Theses

Seafood is vulnerable to species mislabeling due to factors such as complex global supply chains, varying prices, and similar appearance of species. Numerous studies have been published reporting a range of mislabeling rates for various forms of seafood. However, these studies oftentimes focus on lesser-consumed species that are vulnerable to species mislabeling. As a result, the overall mislabeling rate of commercially sold seafood in the U.S. remains unknown, especially for the most consumed species. Thus, the objective of the current study was to compile the results of seafood mislabeling studies into a single resource to provide informative statistics on U.S. …

Catastrophic Progress: A Queer Materialist Analysis Of The 2023 Trans/Bud Light Controversy, Brianna Radke

English (MA) Theses

On April 1, 2023, Dylan Mulvaney, a transgender woman and social media influencer, made a March Madness post on Instagram sponsored by Bud Light. The response from the conservative right was swift and extreme, galvanizing protests against Anheuser-Busch InBev and resulting in a massive loss in sales that is still discussed in news and pop culture circles today. The event offers unique analytic value, particularly through the nexus of queer and materialist theoretical frameworks, providing a glimpse into the growing conflict between big business and queer-allied consumers. From a materialist perspective, the Bud Light/Mulvaney controversy demonstrates how social media – …

Legitimacy Competition: China And The United States Legitimization Of International Criminal Court Referral Decisions, Allison Flame

International Studies (MA) Theses

How do the United States and China legitimize their position regarding United Nations Security Council (UNSC) referrals to the International Criminal Court (ICC)? Existing literature addresses that states seek to gain and maintain legitimacy. However, there is an overall lack of attention given to how state representatives frame key decisions to legitimize the state's stance and if there are correlations between cases. Filling the gap in literature, this project examines how states legitimize their position on referrals to the ICC as permanent members of the UNSC and identifies a pattern in how they do this. Referring to the legitimacy competition …

Waiting For Mahanoy: Examining The Still-Unsettled Jurisprudence Of Online Student Speech, Emily Erickson, Matthew D. Bunker

William & Mary Bill of Rights Journal

This Article first explores the constitutional background of student speech rights, beginning with the Tinker decision and continuing through early court attempts to analyze online, off-campus cases. Next, it examines Mahanoy itself, unpacking the frustratingly murky majority opinion written by Justice Stephen Breyer. The Article then breaks new ground by exploring court decisions in the years since Mahanoy, as jurists continue trying to identify First Amendment boundaries in student speech cases involving bullying, threats, and otherwise offensive speech. A concluding section synthesizes the state of the law and offers perspectives on this vital area of constitutional concern.

This abstract …

Total Hip Arthroplasty Outcomes In A Patient With Moderate To Severe Scoliosis: A Case Study, Rachael Dobbs

Physical Therapy Scholarly Projects

Introduction. The purpose of this case study is to discuss the role of physical therapy in patients who have moderate to severe scoliosis and plan to or have undergone a total hip arthroplasty. In evaluating the case of a female with moderate to severe scoliosis who recently underwent a total hip arthroplasty, it will be determined if physical therapy intervention was successful in improving her symptoms and reducing the risk of further complications.

Case Description. Patient is a 70-year-old female who presents to physical therapy evaluation several weeks post total hip arthroplasty. The patient has comorbidities of osteoarthritis and moderate …

Inpatient Physical Therapy Management Of A Patient Sustaining Multiple Fractures And A Hemorrhagic Temporal Lobe Contusion Due To An Absent Seizure And Fall: A Case Report, Kylie M. Helgeland

Physical Therapy Scholarly Projects

Introduction: A case report for the acute care assessment and treatment of a patient after a seizure and fall that resulted in multiple fractures and a temporal lobe contusion. Every injury has an impact on a patient’s mobility and their ability to perform activities of daily living. Physical therapists need to see each injury and understand how each one can affect the patient and have a barrier on their recovery.

Case description: A 59-year-old female who fell down 3 stairs during an absent seizure resulting in multiple fractures and a temporal contusion. The patient presented with impairments of motor planning, …

Inpatient Rehabilitation And Clinical Decision Making Of A Patient With Severe Stroke And Acute Kidney Injury: A Case Report, Kassandra G. Anshutz

Physical Therapy Scholarly Projects

Background and Purpose: Cerebrovascular accidents (CVA) are common and are estimated to affect around 795,000 people in the United States every year. Cerebrovascular accidents can be detrimental to one’s health and have a wide range of complications including death and decreased independence. Current evidence-based practice supports exercise and movement through physical therapy to restore function and independence. However, current guidelines do not exist for patients with acute kidney injury during stroke recovery.

Case Description: In this case study, we examine a 63-year-old male with a diagnosis of acute ischemic stroke further complicated by severe rhabdomyolysis. Upon initial evaluation and examination, …

Trajectories Of Depression Severity In The First Semester Of College, Nicole A. Kelso

Theses and Dissertations

Depression is a major public health concern among students in higher education. Prior work suggests that depressive symptoms increase during the transition to college. Transfer students face unique challenges during the transition to a new academic institution that may make them particularly vulnerable. There is a critical need to expand prevention efforts. Research that improves identification of students at greatest risk for developing impairing depressive symptoms, and etiological processes contributing to depressive symptoms could aid in the provision of limited prevention resources. Furthermore, longitudinal research tracking symptom trajectories during the transition to college could help inform the timing of preventive …

Understanding Road Users’ Use And Misuse Of Fluorescent And Retroreflective Materials At Night, Savana King

All Dissertations

Nighttime pedestrian fatality rates in the U.S. continue to rise. Nighttime visibility aids – including retroreflective garments – can enhance the conspicuity of pedestrians to drivers at night. Yet, pedestrians rarely take advantage of retroreflectivity and instead often wear fluorescent garments that are not useful at night. This research explored whether road users’ misunderstandings of two critical principles – retroreflectivity and fluorescence – support the misuse of visibility-enhancing garments. This project also explored whether materials that combine retroreflectivity and fluorescence (“combined-performance materials”) circumvent road users’ misconceptions. Two experiments quantified observers’ expectations for how bright fluorescent, retroreflective, or fluorescent-retroreflective materials will …

Release Of Small Molecules From Rubber: Effects Of Materials Properties, Mechanical Loading And Molecular Interactions, Yongcan Du

All Dissertations

Release of small molecules from polymeric materials has wide applications in the delivery systems of active molecules such as drug, fragrance, and semiochemical. Rubber materials are good candidates for the excipients of those systems due to properties such as good flexibility, permeability, and biocompatibility. Factors like material properties, mechanical loading, and molecular interactions may affect the release of small molecules in those systems. Therefore, understanding how those factors affect the release is key to the formulation, design, and evaluation of those systems.

To study the effects of materials properties, vulcanized natural rubber sheets with different crosslink densities, loaded with small …

Scarebnb: An Analysis Of Maryland’S Efforts To Curb The Long-Term Housing Effects Of Short-Term Rentals, Devyn King

University of Baltimore Law Review

No abstract provided.

Witness Recall For Conversation: An Empirical Check On The Hearsay Rule, Susan E. Provenzano, Sarah Brown-Schmidt

Faculty Publications By Year

No abstract provided.

The Olmsted Fault, Southernmost Illinois: A Key To Understanding Seismic Hazard In The Northern New Madrid Seismic Zone, Christopher E. Bexfield

Theses and Dissertations

The northernmost extent of the New Madrid seismic zone in the central USA has been investigated using an integrated approach involving both compressional-wave (P) and horizontally polarized-wave (SH) seismic reflection and regional and dedicated borehole geophysical information in order to assess seismic hazard and risk. Our study area, centered around southernmost Illinois and western Kentucky, USA, represents an area of concentrated facilities (e.g., lock and dam sites and chemical plants on the Ohio River near its confluence with the Mississippi River) as well as an area of high potential soil amplification due to earthquake shaking. Integrated high-resolution seismic reflection profiles …

Parallel Development: Analyzing The Relationship Between Active Transportation Planners And Real Estate Developers In Northwest Arkansas, Jared Davenport

Architecture Undergraduate Honors Theses

The emergence of active transportation infrastructure in the United States has garnered attention from real estate developers, presenting opportunities for capitalizing on a growing market. This trend has prompted shifts in development patterns in various cities, notably in Northwest Arkansas. This region has seen substantial growth in active transportation infrastructure, exemplified by the Razorback Greenway, alongside remarkable economic expansion fueled by corporate investments, notably from Walmart and the Walton family. As real estate development and active transportation infrastructure intersect, it's essential to understand their implications for sustainability. This study aims to explore the strategies, motivations, and perspectives of planners and …

Towards A New Urbanism- Using Artificial Intelligence To Reconcile Modernist Aesthetics With New Urbanist Principles, Nicholas Hurley

Architecture Undergraduate Honors Theses

As urbanization and densification of cities have become undeniable trends of the past few centuries, designers have theorized ways of building the ideal environment for its inhabitants to thrive. These methods include the Garden Cities, Late Modern Housing Estates, and New Urbanism. This study will focus on New Urbanism. Known for its reluctance to embrace new architectural styles and ways of building, incorporating contemporary architectural styles presents a challenge to the future applicability of New Urbanism.

To analyze this issue, this study will leverage the ability of Artificial Intelligence image generation software to evaluate the compatibility of New Urbanism principles …

Geometric Principles In Architecture Aesthetics, Vincent Gemmiti

Architecture Undergraduate Honors Theses

This study focuses on geometric formalism in three major monuments across different architectural eras in time. The use of three distinct geometric principles to outline the use of pure or manufactured shapes and figures helps to discover and isolate an aesthetic component of architecture within which it is contained. A collection of studies are implemented and are focused on orthographic drawings from each monument in horizontality and verticality, consisting of a dual set of overlay and interpretative drawings for each type of orthographic representation for each monument. A discussion follows and highlights the changes or similarities over time the role …

Who Will Speak For The Trees? How The Save Our Sequoias Act Underscores The Urgent Need To Protect Giant Sequoias And The Tule River Indian Reservation From Wildfire Destruction, Bradly Demoll

UC Law Environmental Journal

Increasing rates of high-severity wildfires threaten the existence of giant sequoia trees, as well as the reservation and sacred cultural sites of the Tule River Indian Tribe. Decades of fire suppression have created a ticking time bomb across millions of acres of land. The result: the last two fire seasons alone wiped out nearly 20% of all giant sequoias on the planet and burned thousands of acres of forests across the Tribe’s land. This Article explores the ecological background and significance of the giant sequoias and their relationship to the Tribe. It then examines the existing legal framework for sequoia …

Real-Time Measurements From Wearable Sensors To Enhance Stability On Uneven Terrain, Sophie Copelin

Biomedical Engineering Undergraduate Honors Theses

The presented thesis is a study of sensation associated with inversion/eversion movement about the anterior/posterior axis. The long-term goal is to create a system that provides feedback to a prosthesis user, so their chances of falling is decreased. This feedback system would use wearable sensors to detect certain angles, so that sensory feedback could be provided. The study aimed to determine if Xsens Movella DOT sensors could be used in a system like this, so the accuracy of the Xsens Movella DOT sensors was assessed and the difference in angles that could be determined by them when compared to that …

Evaluating The Epidemiological, Hormonal, And Psychosocial Sex-Based Differences In Sports-Related Concussion Outcomes, Samantha Kanny

All Dissertations

Sports-related concussions (SRCs) affect approximately 3.8 million athletes in the United States per year. A multitude of risk factors including age, sex, concussion history and prior medical conditions have been observed to significantly increase sports-related concussion symptom burden. Researchers have posited many reasons to explain sex-based differences in SRC outcomes, often categorized by biological characteristics or sociocultural factors, however, females are vastly underrepresented in sports-related concussion research, making it difficult to understand the true mechanisms underlying SRC sex-based differences. The goal of this dissertation is to help fill the current gap in knowledge on sex-based differences in sports-related concussion outcomes. …

The Development Of A Convenient And Consistent Methodology For Flight Proficiency To Certify Multi-Rotor Uas Pilots For State Departments Of Transportation, Colin Dees

All Dissertations

To fly an unmanned aircraft system (UAS), commonly referred to as a “drone,” the Federal Aviation Administration (FAA) requires pilots to pass a knowledge test. There is no requirement at the state or federal level for drone operators to demonstrate the ability to operate a UAS. The National Institute of Science and Technology (NIST) has created an exam for public and private entities to assess basic UAS flight proficiency. It is the only nationally recognized flight proficiency protocol. NIST does not provide a scoring recommendation and leaves it to the user to determine the minimum criteria to pass. There is …

Rhettech Wrtc Undergraduate Journal Volume 6 Full Issue

RhetTech

No abstract provided.

My Literacy Adventure With People, Ai, And A Piglet, Shota Maeda

RhetTech

This work is a "multiliteracy narrative," describing my history of literacy development from four perspectives: Japanese, English, digital literacy, and global citizenship. The main focus of this paper is how I overcame the challenge of acquiring high language skills through interaction with the people around me. Also, I explore how literacy skills can empower me to survive in today’s world. Firstly, this narrative starts with my literacy development in my native language (Japanese), which began at a young age when my parents started reading me a book. As I entered elementary school, my love for reading deepened. Even though I …

The Media’S Representation Of Female Athletes During Drug Scandals, Cassandra Leigh Lavigne

Honors Program Theses and Projects

No abstract provided.