Digital Commons Network^™

Multi-Omic Single-Cell Integration For Understanding T Cell Responses In Acute Myeloid Leukemia, Poonam Desai

Dissertations and Theses (Open Access)

In recent years, translational initiatives have gained significant traction within the medical community. Clinical parameters alone have been insufficient to fully understand the intricate mechanisms governing patient responses to disease and therapy. Additionally, single-cell technologies have rapidly advanced to a point where generation of large patient-based datasets is financially and logistically feasible. The integration of clinical information with multi-omic single-cell technologies enables the formation of data-driven hypotheses pertaining to the mechanisms of disease progression and therapeutic resistance. Acute Myeloid Leukemia (AML) is a rapidly-progressing cancer of the bone marrow with poor prognoses and dismal outcomes. Of the adult patients that …

The Relationship Between Communication Styles And Nonverbal Communication Level: A Study On Tourist Guides, Melike Sak, Ali Turan Bayram, Gül Erkol Bayram, Anuj Kumar, Shakeel Basheer

Journal of Mediterranean Tourism Research

Communication, a fundamental tool in human interaction, encompasses a variety of methods and techniques. One such method, non-verbal communication, is a form of expression that transcends words or language. Instead, it relies on a spectrum of non-verbal cues, such as body language, eye contact, physical posture, gestures, and facial expressions, to convey meaning. In the context of tourist guiding, non-verbal communication is a key element. The non-verbal communication skills of tourist guides are pivotal in shaping the quality of the tour experience. By employing non-verbal communication techniques, guides can significantly enhance the quality of interaction with tourists, thereby optimizing communication …

Multi-Tiered System Of Supports: Positive Student Impacts, Taylor Panoch

Master's Theses & Capstone Projects

Research shows the plethora of benefits that a Multi-Tiered System of Supports (MTSS) has on students of all ages when implemented with fidelity. Through MTSS, students receive leveled interventions appropriate to their needs, which has proven to be valuable. Studies have shown that a Multi-Tiered System of Supports has great impacts on academics, behavior, students with Individualized Education Plans (IEPs), English Language Learners (ELLs), students who have experienced trauma, mental health and professional development (PD) for staff. With these important research findings in mind, this school created a school improvement plan implementing a Multi-Tiered System of Supports within their middle …

Judicial Power And Potential Unconstitutionality: A Scholastic Perspective, Kevin C. Walsh

Catholic University Law Review

This essay is an exercise in constructive retrieval of the traditional American understanding of judicial power with respect to judicial disregard of potentially unconstitutional laws when identifying rules of decision in constitutional adjudication.

This retrieval makes use of the act/potency distinction from Scholastic philosophy, Thomas Aquinas’s distinction between ius and lex, and John Marshall’s canonical account of the judicial application of the Constitution as a rule of decision in Marbury v. Madison to diagnose the cause of contemporary severability doctrine’s problems and to identify a basic framework for replacement doctrine.

I contend that the doctrinal pieces for the replacement …

The Youth Tax In Parole Hearings, David M. N. Garavito, Amelia Hritz, John H. Blume

South Carolina Law Review

No abstract provided.

The Children Are Our Future (Not Our Future Criminals): Protecting South Carolina's Youngest Citizens By Setting A Minimum Age Of Juvenile Court Jurisdiction, Peggy D. Nicholson

South Carolina Law Review

No abstract provided.

Alone & Afraid: The Need For Elimination Of Solitary Confinement In South Carolina, Sydney Ford

South Carolina Law Review

No abstract provided.

Rethinking Youth Release: An Analysis Of The South Carolina Board Of Juvenile Parole In The Context Of The Evolving Landscape Of Reforms Of Juvenile Release Authorities, Aleksandra Chauhan

South Carolina Law Review

No abstract provided.

City Of Concord, Fy 2024 Annual Report, Concord Town Representatives

Concord, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Digital Transformation Of The Accounting And Audit Industry In Kosovo, Lis Musa

Theses

This capstone project analyzes how Kosovo's audit and accounting industry is being affected by digital transformation. Its aim is to explore how digitalization affects skills gaps, job accuracy, company costs, and productivity in different sectors at a time when technological breakthroughs are drastically changing industry. Professionals from Big 10 accounting and audit firms as well as a local Kosovo accounting business were interviewed to gather insights on the potential and difficulties brought about by digital tools and technologies. Research findings show that digital transformation is considerably bridging the skills gap in the industry, imposing constant professional development and adjustment to …

Inefficiencies Of Carbon Trading Markets, Nicola Borri, Yukun Liu, Aleh Tsyvinski, Xi Wu

Cowles Foundation Discussion Papers

The European Union Emission Trading System is a prominent market-based mechanism to reduce emissions. While the theory is well-understood, we are the first to study the whole cap-and-trade mechanism as a financial market. Analyzing the universe of transactions in 2005-2020 (more than one million records of granular transaction data), we show that this market features significant inefficiencies undermining its goals. First, about 40% of firms never trade in a given year. Second, many firms only trade during surrendering months, when compliance is immediate and prices are predictably high. Third, a number of operators engage in speculative trading, exploiting private information.

Eric Rambert V. Warden Greene Sci

2024 Decisions

USDC for the Eastern District of Pennsylvania

Saaed Moslem V. Stephen Strauhs

2024 Decisions

USDC for the District of New Jersey

Usa V. Arthur Rowland

2024 Decisions

USDC for the Eastern District of Pennsylvania

Luis Diaz Almanzar V. Attorney General United States

2024 Decisions

Agency

Swosu Fact Book Summer 2024, Joel Harrel Kendall, Diane Fitzsimmons, Kelsi Burghardt

Fact Books

Starting in 2024SU, Southwestern Oklahoma State University will produce a Summer Fact Book, which will provide information on enrollment, student demographics, and academic programs for the summer semester. The report is designed to help faculty, staff, administrators, and external stakeholders better understand the student body and university trends. The data analyzed for this report was collected on the 5^th day of each summer semester 2015 through 2024.

Community Health Volunteers’ Experiences Of Implementing Covid-19 Vaccine Education And Promotion In Kenya: A Qualitative Descriptive Study, Constance Shumba, Peterson Kiraithe, Isabel Kambo, Sheila Shaibu

School of Nursing & Midwifery, East Africa

Background: Vaccination was a key measure in the COVID-19 pandemic response, though much work was needed to promote vaccine uptake and acceptance. In Kenya, Community Health Volunteers (CHVs) played a key role in vaccine education and promotion. We conducted this study to explore CHVs’ experiences of implementing COVID-19 vaccine education and promotion during the pandemic to increase COVID-19 vaccine uptake in two areas of Kenya.

Methods: In a qualitative descriptive study, we conducted 30 structured in-depth interviews with 20 CHVs and 10 Community Health Assistants from rural Kilifi County and Kangemi, an urban informal settlement of Nairobi County in Kenya …

Formula Integrated Monocoque Development, Hayden Wagner, Aaron Fang, Elijah Schulz, Carson Smith

Mechanical Engineering

Every year the Cal Poly Racing FSAE club set out to create two separate race cars to compete in the upcoming formula combustion and formula electric competitions. Both the combustion and electric formula cars operated on the same vehicle platform with the powertrain systems being the main difference between the two cars. Cal Poly Racing FSAE is the only school in California to run a full carbon fiber monocoque chassis, with each chassis design operating on a roughly four year design cycle. A new FSAE senior project team has set out to improve upon the previous chassis design as the …

Using Data-Driven Decision-Making To Guide Instructional Strategies In The Classroom: A School Improvement Plan, Samantha Dolezal

Master's Theses & Capstone Projects

This paper explores the use of data-driven decision-making in educational settings to improve instructional strategies and student outcomes. Educators can utilize various data sources, such as state summative assessments and classroom formative assessments, to make informed decisions tailored to their students' diverse needs. This school improvement plan suggests that data-driven decision-making can lead to a more personalized learning experience, targeted instructional strategies, and better teacher responsiveness to student needs. The plan also outlines the responsibilities, resources, and process for monitoring success and challenges for each student in schools looking to implement data-driven approaches in teaching and learning.

Improving Fine Motor And Handwriting Skills, Anne Weber

Master's Theses & Capstone Projects

Early childhood years are a crucial time for the development of fine motor and handwriting skills. Research links these skills to success in other academic content such as letter identification and counting skills. Gripping, pinching, and manipulating interventions have been shown to improve fine motor and handwriting skills. A school improvement plan was created to address the lack of time dedicated to these two skills in a rural Iowa public school. A plan to implement fine motor and handwriting curriculums in preschool through first grade is described in detail. With successful implementation, fine motor and handwriting skills will significantly improve.

Hd-Tdcs Over Left Supplementary Motor Area Differentially Modulated Neural Correlates Of Motor Planning For Speech Vs. Limb Movement, Fatemeh Tabari, Celeste Patron, Hope Cryer, Karim Johari

Faculty Publications

The supplementary motor area (SMA) is implicated in planning, execution, and control of speech production and limb movement. The SMA is among putative generators of pre-movement EEG activity which is thought to be neural markers of motor planning. In neurological conditions such as Parkinson's disease, abnormal pre-movement neural activity within the SMA has been reported during speech production and limb movement. Therefore, this region can be a potential target for non-invasive brain stimulation for both speech and limb movement. The present study took an initial step in examining the application of high-definition transcranial direct current stimulation (HD-tDCS) over the left …

Application Of Near-Infrared Spectroscopy For Hay Evaluation At Different Degrees Of Sample Preparation, Eun Chan Jeong, Kun Jun Han, Farhad Ahmadi, Yan Fen Li, Li Li Wang, Young Sang Yu, Jong Geun Kim

Faculty Publications

Objective: A study was conducted to quantify the performance differences of the near-infrared spectroscopy (NIRS) calibration models developed with different degrees of hay sample preparations. Methods: A total of 227 imported alfalfa (Medicago sativa L.) and another 360 imported timothy (Phleum pratense L.) hay samples were used to develop calibration models for nutrient value parameters such as moisture, neutral detergent fiber, acid detergent fiber, crude protein, and in vitro dry matter digestibility. Spectral data of hay samples prepared by milling into 1-mm particle size or unground were separately regressed against the wet chemistry results of the abovementioned parameters. Results: The …

A Longitudinal Evaluation Of Personalized Intrinsic Network Topography And Cognitive Decline In Parkinson's Disease, Renxi Li, Vincent Pozorski, Kevin Dabbs, Maureen Haebig, Christopher R. Cox, Colleen Pletcher, Alexandra Wey, Amy Barzgari, Frances Theisen, Ozioma Okonkwo, Catherine L. Gallagher

Faculty Publications

Resting state functional magnetic resonance imaging (R-fMRI) offers insight into how synchrony within and between brain networks is altered in disease states. Individual and disease-related variability in intrinsic connectivity networks may influence our interpretation of R-fMRI data. We used a personalized approach designed to account for individual variation in the spatial location of correlation maxima to evaluate R-fMRI differences between Parkinson's disease (PD) patients who showed cognitive decline, those who remained cognitively stable and cognitively stable controls. We compared fMRI data from these participant groups, studied at baseline and 18 months later, using both network-based statistics (NBS) and calculations of …

Effects Of The Menstrual Cycle And Hormonal Contraceptive Use On Metabolic Outcomes, Strength Performance, And Recovery: A Narrative Review, Hannah E. Cabre, Lacey M. Gould, Leanne M. Redman, Abbie E. Smith-Ryan

Clinical Research Faculty Publications

The effects of female sex hormones on optimal performance have been increasingly recognized as an important consideration in exercise and sport science research. This narrative review explores the findings of studies evaluating the effects of menstrual cycle phase in eumenorrheic women and the use of hormonal contraception (oral contraceptives and hormonal intrauterine devices) on metabolism, muscular strength, and recovery in active females. Ovarian hormones are known to influence metabolism because estrogen is a master regulator of bioenergetics. Importantly, the menstrual cycle may impact protein synthesis, impacting skeletal muscle quality and strength. Studies investigating muscular strength in eumenorrheic women report equivocal …

Toward Concurrent Identification Of Human Activities With A Single Unifying Neural Network Classification: First Step, Andrew Smith, Musa Azeem, Chrisogonas O. Odhiambo, Pamela J. Wright, Hanim E. Diktas, Spencer Upton, Corby K. Martin, Brett Froeliger, Cynthia F. Corbett, Homayoun Valafar

Clinical Research Faculty Publications

The characterization of human behavior in real-world contexts is critical for developing a comprehensive model of human health. Recent technological advancements have enabled wearables and sensors to passively and unobtrusively record and presumably quantify human behavior. Better understanding human activities in unobtrusive and passive ways is an indispensable tool in understanding the relationship between behavioral determinants of health and diseases. Adult individuals (N = 60) emulated the behaviors of smoking, exercising, eating, and medication (pill) taking in a laboratory setting while equipped with smartwatches that captured accelerometer data. The collected data underwent expert annotation and was used to train a …

Validity And Reliability Of Meu Educativo®: A New Tool To Assess Fundamental Movement Skills In School-Aged Children, Fernando Garbeloto, Sara Pereira, Go Tani, Jean Philippe Chaput, David F. Stodden, Rui Garganta, Donald Hedeker, Peter T. Katzmarzyk, José Maia

Population and Public Health Science Faculty Publications

Objectives: There is evidence showing that children's proficiency in fundamental movement skills (FMS) is positively related to weight status, physical activity, fitness levels, cognitive development, as well as academic performance. Yet, the feasibility of FMS assessment is challenging, especially with relatively large samples of children. This article presents a new tool named Meu Educativo® to assess children's FMS levels, including its validity and reliability. Methods: We relied on the validity evidence approach based on test content to develop the FMS assessment checklist and the rating system with a team of experts. In this article, we used five FMS (stationary dribbling, …

Gradient Synchronization For Multivariate Functional Data, With Application To Brain Connectivity, Yaqing Chen, Shu Chin Lin, Yang Zhou, Owen Carmichael, Hans Georg Müller, Jane Ling Wang

Clinical Research Faculty Publications

Quantifying the association between components of multivariate random curves is of general interest and is a ubiquitous and basic problem that can be addressed with functional data analysis. An important application is the problem of assessing functional connectivity based on functional magnetic resonance imaging (fMRI), where one aims to determine the similarity of fMRI time courses that are recorded on anatomically separated brain regions. In the functional brain connectivity literature, the static temporal Pearson correlation has been the prevailing measure for functional connectivity. However, recent research has revealed temporally changing patterns of functional connectivity, leading to the study of dynamic …

Grb 180128a: A Second Magnetar Giant Flare Candidate From The Sculptor Galaxy, Aaron C. Trigg, Eric Burns, Oliver J. Roberts, Michela Negro, Dmitry S. Svinkin, Matthew G. Baring, Zorawar Wadiasingh, Nelson L. Christensen, Igor Andreoni, Michael S. Briggs, Niccolò Di Lalla, Dmitry D. Frederiks, Vladimir M. Lipunov, Nicola Omodei, Anna V. Ridnaia, Peter Veres, Alexandra L. Lysenko

Faculty Publications

Magnetars are slowly rotating neutron stars that possess the strongest magnetic fields known in the cosmos (10¹⁴-10¹⁵ G). They display a range of transient high-energy electromagnetic activity. The brightest and most energetic of these events are the gamma-ray bursts (GRBs) known as magnetar giant flares (MGFs), with isotropic energies Eiso10⁴⁴10⁴⁶ erg. Only seven MGF detections have been made to date: three unambiguous events occurred in our Galaxy and the Magellanic Clouds, and the other four MGF candidates are associated with nearby star-forming galaxies. As all seven identified MGFs are bright at Earth, additional weaker …

The Chemistry Of Heavy Elements: Probing Relativistic Chemical Bonding, Barbara Maria Teixeira Costa Peluzo

Chemistry Theses and Dissertations

The bottommost part of the periodic table has a unique chemistry, where the high velocities of the inner-shell electrons prevent their description by the usual Schrödinger equation. The resulting so-called relativistic effects have numerous chemical implications, on both macro and microscale, ranging from physical properties to reactivity. However, experimental probes on these intriguing atoms are limited by their natural availability and, more importantly, the danger associated with their radioactivity. Quantum chemical calculations, on the other hand, face the challenge of far more complex algebra, which demands substantial computational resources. Relativistic Hamiltonians, which act over all electrons in the system, are …

Lawrence, Spring/Summer 2024, Lawrence University

Alumni Magazines

No abstract provided.