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Obstetrics And Gynecology Subspecialty Faculty: A Workforce Analysis, Morgan Steffen Jun 2024

Obstetrics And Gynecology Subspecialty Faculty: A Workforce Analysis, Morgan Steffen

Graduate Medical Education Research Journal

NA


Collaboration Between Orthopedic Surgery And Psychiatry Residency Programs To Improve Education About Orthopaedic Pain Management For Patients With Mental Illness, Keagan Gertz Jun 2024

Collaboration Between Orthopedic Surgery And Psychiatry Residency Programs To Improve Education About Orthopaedic Pain Management For Patients With Mental Illness, Keagan Gertz

Graduate Medical Education Research Journal

NA


Changes In Anterior Tibial Translation Are Not Associated With Degradation In Weightbearing Cartilage Of The Knee Following Anterior Cruciate Ligament Reconstruction, Tyler Kallman Jun 2024

Changes In Anterior Tibial Translation Are Not Associated With Degradation In Weightbearing Cartilage Of The Knee Following Anterior Cruciate Ligament Reconstruction, Tyler Kallman

Graduate Medical Education Research Journal

NA


Suprachoroidal Triamcinolone For The Treatment Of Refractory Macular Edema Secondary To Noninfectious Uveitis, Marc Ohlhausen Jun 2024

Suprachoroidal Triamcinolone For The Treatment Of Refractory Macular Edema Secondary To Noninfectious Uveitis, Marc Ohlhausen

Graduate Medical Education Research Journal

NA


Cost-Effectiveness Modeling Of The Use Of Chlorhexidine Gluconate Irrigation Solution To Prevent Postoperative Infection In Inflatable Penile Prosthesis, Alan Quach Jun 2024

Cost-Effectiveness Modeling Of The Use Of Chlorhexidine Gluconate Irrigation Solution To Prevent Postoperative Infection In Inflatable Penile Prosthesis, Alan Quach

Graduate Medical Education Research Journal

NA


The Effects Of Analogy Teaching On Sport Skill Acquisition In Children, Mohsen Afrouzeh, Ferman Konukman, Rabiu Muazu Musa, Mohammad Sadeq Afroozeh, Ertan Tufekcioglu, Bijen Filiz Jun 2024

The Effects Of Analogy Teaching On Sport Skill Acquisition In Children, Mohsen Afrouzeh, Ferman Konukman, Rabiu Muazu Musa, Mohammad Sadeq Afroozeh, Ertan Tufekcioglu, Bijen Filiz

Baltic Journal of Health and Physical Activity

Introduction: The primary task of physical educators is to teach motor skills to beginners, and motor learning studies continually strive to find better ways to optimize the skill acquisition process. In line with this, our study aims to evaluate and compare the effectiveness of two learning methods, analogy learning and explicit learning, in promoting children's acquisition of novel motor skills. We specifically focus on skills that differ biomechanically and kinematically from skills learned through explicit instructions, and we also investigate how the physical form of the skill evolves with practice. Material and Methods: Forty-five right-handed healthy beginner male students (mean …


The Use Of Grasslands To Improve Water Quality In The New York City Watershed, D J. Flaherty, J Drelich Jr Jun 2024

The Use Of Grasslands To Improve Water Quality In The New York City Watershed, D J. Flaherty, J Drelich Jr

IGC Proceedings (1977-2023)

The purpose of this paper is to demonstrate how grasslands are used in the New York City (NYC) Watershed to improve water quality. A Watershed Agricultural Program was established to voluntarily implement Pollution Prevention Best Management Practices on watershed farms. Grasslands have been used in Whole Farm Plans to reduce nutrients, sediments and other toxic materials reaching New York City’s water supply. Rotational grazing has been used to limit access to streams and stream banks and improve nutrient distribution on pastures. Improved grassland management also helps correct the nutrient balance on the farm and facilitates better nutrient management. Brush removal …


Policy Options For Decreasing N And P2o5 Losses From Grassland Based Dairy Farms, P.B M. Berentsen, G.W J. Giesen Jun 2024

Policy Options For Decreasing N And P2o5 Losses From Grassland Based Dairy Farms, P.B M. Berentsen, G.W J. Giesen

IGC Proceedings (1977-2023)

Policy instruments for reducing nutrient losses include extension and education, research, financial incentives such as subsidies and levies, and regulations. The potential of these instruments for reducing nitrogen (N), phosphate (P2O5), and ammonia (NH3) losses is examined for Dutch specialized dairy farms on sandy soils. A linear programming model is used to estimate policy impacts. Results indicate that efficiency improvements through extension, education, and research alone have the potential to decrease total N losses to government target levels in 2005 and to erase 92% of the gap between base and target P2O5 losses, but only 24% of the corresponding NH3 …


Benefits Of Coding In The Elementary Classroom, Samantha Panek Jun 2024

Benefits Of Coding In The Elementary Classroom, Samantha Panek

Graduate Teacher Education

This capstone project focused on the potential benefits of coding, specifically for elementary-aged children. The literature review analyzed fifteen studies from around the world about benefits that could be gained from coding. Students coded with unplugged methods, block-based programs, and robots. Problem-solving was a common benefit found in research about elementary coding. Research also supported that specific content areas could be positively impacted through coding such as computational thinking and mathematical reasoning. Coding encouraged transferable life skills such as planning, collaboration, and creativity. (Arslan & Çelik, 2022; Murcia et al., 2020; O’Grady-Jones & Grant,2023;Wilson, 2020). Additionally, exposure to coding at …


Shattering The Mask: Unveiling The Destructive Force Of Misogynoir, Ledominique Hubbard Jun 2024

Shattering The Mask: Unveiling The Destructive Force Of Misogynoir, Ledominique Hubbard

Dissertations

As a Black woman, my professional journey has been consistently marred by encounters with racism and gender bias. In this research, I employed autoethnography to shed light on my experiences and meticulously examine the challenges of misogynoir I faced while holding pivotal positions, including that of a detested team leader, an ingenious instructional teacher, and an anti-racist assistant principal across three distinct school campuses in two states. My narrative unfolds in various contexts, notably as the sole Black female teacher and team leader within nine elementary schools in a predominantly white, female-staffed rural district. Furthermore, I underscore my role as …


Assessing The Effects Of Repetitive Mild Traumatic Brain Injury On Risk/Reward Decision Making And Catecholamine Associated Proteins, Christopher Knapp Jun 2024

Assessing The Effects Of Repetitive Mild Traumatic Brain Injury On Risk/Reward Decision Making And Catecholamine Associated Proteins, Christopher Knapp

Theses and Dissertations

Mild traumatic brain injury (mTBI) disrupts cognitive processes that influence risk taking behavior; however, the effects of repetitive mild injury (rmTBI) or whether these outcomes are sex specific are unknown. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is densely innervated by catecholaminergic fibers. Aberrant PFC catecholamine activity has been documented following TBI and may underlie TBI-induced risky behavior. Here, we exposed rats to sham (no injury), single, or three closed-head controlled cortical impact (CH-CCI) injuries to characterize the effects of rmTBI on 1) risk/reward decision making behavior using a probabilistic discounting task (PDT) and 2) levels …


Black Men Who Participate In An Urban Community College Men Of Color Initiative: A Phenomenological Study, Steven Hardy Jun 2024

Black Men Who Participate In An Urban Community College Men Of Color Initiative: A Phenomenological Study, Steven Hardy

Theses and Dissertations

This phenomenological study explored the perceptions and experiences of Black men who participated in the MOCI. The study uncovered insights into what aspects of the program were effective and where improvements could be made according to the student participants. Employing a phenomenological design, the research identified commonalities among the participants' experiences (Creswell & Creswell, 2018; Moustakas, 1994; Rubin & Rubin, 2012). The structure of understanding surrounding participants in the MOCI program was meticulously facilitated using phenomenology (Creswell & Creswell, 2018). The interviews were not just semi-structured but also empathetic, with prepared open-ended questions followed by probing inquiries, all aimed at …


The Role Of Stakeholder Involvement In Enhancing Safe Drinking Water Infrastructure: An Interpretative Structural Modeling Approach, Awlya Rahmanea, Ayomi Dita Rarasati Jun 2024

The Role Of Stakeholder Involvement In Enhancing Safe Drinking Water Infrastructure: An Interpretative Structural Modeling Approach, Awlya Rahmanea, Ayomi Dita Rarasati

CSID Journal of Infrastructure Development

One of the primary goals listed in the Sustainable Development Goals (SDGs) is to “Achieve universal and equitable access to safe and affordable drinking water for all,” as stated in SDG 6.1. To obtain this goal, the Government of Indonesia has developed the 2020-2024 National Medium-Term Development Plan (RPJMN), which has set specific targets including achieving 100% access to decent drinking water, 15% access to safe drinking water, and establishing 10 million house connections. The Ministry of National Development Planning has established a goal of achieving 45% access to safe drinking water by 2030 as part of the SDGs. However, …


Comparison Of The Accuracy Of Contour Data In Photogrammetric And Terrestrial Surveys, Hendra Saputra, Roma Rizki, Marhadi Sastra Jun 2024

Comparison Of The Accuracy Of Contour Data In Photogrammetric And Terrestrial Surveys, Hendra Saputra, Roma Rizki, Marhadi Sastra

CSID Journal of Infrastructure Development

Understanding and accurately representing the Earth's surface is crucial in various scientific and practical fields. Over the past decades, measurement technology has seen remarkable advancements, offering an array of methods for recording and analyzing Earth's surface with increasing precision and efficiency. Two primary approaches have risen to the forefront of this field: the Digital Terrain Model (DTM) and terrestrial measurements using a Total Station. Although both technologies offer unique advantages and constraints, a comprehensive direct comparison between these two methods often remains an underexplored area. The Digital Elevation Model (DEM) represents the height of the ground surface resulting from acquisition …


Neural Circuits Expressing The Serotonin 2c Receptor Regulate Memory In Mice And Humans, Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin, Katherine Lawler, Julia M. Keogh, Elana Henning, Dong Kee Lee, Meng Yu, Longlong Tu, Nan Zhang, Kristine M. Conde, Junying Han, Zili Yan, Nikolas A. Scarcelli, Lan Liao, Jianming Xu, Qingchun Tong, Hui Zheng, Zheng Sun, Yongjie Yang, Chunmei Wang, Yanlin He, I. Sadaf Farooqi, Yong Xu Jun 2024

Neural Circuits Expressing The Serotonin 2c Receptor Regulate Memory In Mice And Humans, Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin, Katherine Lawler, Julia M. Keogh, Elana Henning, Dong Kee Lee, Meng Yu, Longlong Tu, Nan Zhang, Kristine M. Conde, Junying Han, Zili Yan, Nikolas A. Scarcelli, Lan Liao, Jianming Xu, Qingchun Tong, Hui Zheng, Zheng Sun, Yongjie Yang, Chunmei Wang, Yanlin He, I. Sadaf Farooqi, Yong Xu

Division of Basic Science Faculty Publications

Declined memory is a hallmark of Alzheimer’s disease (AD). Experiments in rodents and human postmortem studies suggest that serotonin (5-hydroxytryptamine, 5-HT) plays a role in memory, but the underlying mechanisms are unknown. Here, we investigate the role of 5-HT 2C receptor (5-HT2CR) in regulating memory. Transgenic mice expressing a humanized HTR2C mutation exhibit impaired plasticity of hippocampal ventral CA1 (vCA1) neurons and reduced memory. Further, 5-HT neurons project to and synapse onto vCA1 neurons. Disruption of 5-HT synthesis in vCA1-projecting neurons or deletion of 5-HT2CRs in the vCA1 impairs neural plasticity and memory. We show that a selective 5-HT2CR agonist, …


Critical Success Factors In Pump Production To Increase Lean Manufacturing Project Performance, I Bayu Dwianditya, Leni Sagita Riantini, Yusuf Latief Jun 2024

Critical Success Factors In Pump Production To Increase Lean Manufacturing Project Performance, I Bayu Dwianditya, Leni Sagita Riantini, Yusuf Latief

CSID Journal of Infrastructure Development

Floods represent a significant global disaster, occurring more frequently and causing severe damage. The effective production of pumps is crucial in supporting flood infrastructure projects. Lean Manufacturing (LM) and Project Management (PM) approaches must be incorporated to improve pump production manufacturing. Therefore, this study aims to identify the critical success factors that enhance LM performance in pump production projects for flood management through surveys conducted among pump manufacturers, governmental bodies, and relevant stakeholders engaged in flood infrastructure projects. The study's results highlight the importance of understanding and analyzing project complexity, aligning pump design with project requirements, and mastering processes and …


Analyzing The Effect Of The Construction Safety Audit Model Using The Business Process Model And Notation (Bpmn) Method On Improving Communication And Collaboration Between Stakeholders., Muhammad Ghazali, Danang Budi Nugroho, Yusuf Latief Jun 2024

Analyzing The Effect Of The Construction Safety Audit Model Using The Business Process Model And Notation (Bpmn) Method On Improving Communication And Collaboration Between Stakeholders., Muhammad Ghazali, Danang Budi Nugroho, Yusuf Latief

CSID Journal of Infrastructure Development

The significant increase in infrastructure development is directly proportional to the rising accident rate in the construction sector, making it one of the highest-risk sectors for accidents. This phenomenon indicates that existing construction safety audits have not been effective in preventing accidents, largely because audits are generally conducted only at the construction stage. Audits at the design stage, however, have the potential to impact accident prevention significantly. Therefore, this research aims to develop a construction safety audit model using the Business Process Model and Notation (BPMN) and analyzes the impacts on stakeholder communication and collaboration. BPMN was chosen because it …


Investigating The Relationship Among The Construction Safety Plan, Knowledge Management, Audit Process, Information System, Web, And Bim With Construction Safety Performance, Zafira Alysha Fadli, Yusuf Latief, Danang Budi Nugroho Jun 2024

Investigating The Relationship Among The Construction Safety Plan, Knowledge Management, Audit Process, Information System, Web, And Bim With Construction Safety Performance, Zafira Alysha Fadli, Yusuf Latief, Danang Budi Nugroho

CSID Journal of Infrastructure Development

The rapid growth of high-rise building construction in Indonesia has led to a significant increase in accidents, necessitating a robust audit process for construction safety. This research investigates the relationship between construction safety plans (CSPs), audit processes, knowledge management (KM), information systems, the web, and BIM on construction safety performance, aiming to develop a BIM-based KM audit process. To analyze the significance level of various indicators for each variable considerable importance, a mixed-methods approach was employed, combining qualitative insights from expert interviews with quantitative analysis using Structural Equation Modeling (SEM) via SmartPLS. The findings in the study reveal that the …


The Fate Of Fixed Nitrogen In Santa Barbara Basin Sediments During Seasonal Anoxia, Xuefeng Peng, David J. Yousavich, Annie Bourbonnais, Frank Wenzhöfer, Felix Janssen, Tina Treude, David L. Valentine Jun 2024

The Fate Of Fixed Nitrogen In Santa Barbara Basin Sediments During Seasonal Anoxia, Xuefeng Peng, David J. Yousavich, Annie Bourbonnais, Frank Wenzhöfer, Felix Janssen, Tina Treude, David L. Valentine

Faculty Publications

Despite long-standing interest in the biogeochemistry of the Santa Barbara Basin (SBB), there are no direct rate measurements of different nitrogen transformation processes. We investigated benthic nitrogen cycling using in situ incubations with 15NO 3̅  addition and quantified the rates of total nitrate (NO 3̅) uptake, denitrification, anaerobic ammonia oxidation (anammox), N2O production, and dissimilatory nitrate reduction to ammonia (DNRA). Denitrification was the dominant NO 3̅ reduction process, while anammox contributed 0 %–27 % to total NO 3̅ reduction. DNRA accounted for less than half of NO 3̅ reduction except at the …


An Evaluation Of The Premack Contingency To Increase Physical Activity In Teenagers With Autism Spectrum Disorder, Shreeya S. Deshmukh Jun 2024

An Evaluation Of The Premack Contingency To Increase Physical Activity In Teenagers With Autism Spectrum Disorder, Shreeya S. Deshmukh

USF Tampa Graduate Theses and Dissertations

The United States Department of Health and Human Services (2018) recommends that teenagers engage in physical activity to improve their cardiovascular health and muscle and bone strength. Yet, most teenagers with and without autism spectrum disorder do not meet the recommended guidelines for physical activity. Research related to promoting physical activity has evaluated group contingencies, reinforcement-based interventions, and antecedent interventions; however, these interventions are time-intensive, require many resources, or are ineffective. The purpose of this study was to extend Allen and Iwata (1980) by reinforcing completion of a low-probability exercise to a specified criterion with access to a high-probability exercise. …


The Effect Of A Contextualized Dosage Calculation Learning Intervention On Pre-Nursing Students' Math Self-Efficacy And Ability To Pass High Stakes Dosage Calculation Examination On First Attempt, Eileen V. Weatherby Jun 2024

The Effect Of A Contextualized Dosage Calculation Learning Intervention On Pre-Nursing Students' Math Self-Efficacy And Ability To Pass High Stakes Dosage Calculation Examination On First Attempt, Eileen V. Weatherby

Dissertations

Many students in pre-licensure nursing programs struggle with calculating accurate medication dosages even though they meet the numeracy requirements for application to the nursing programs. Most pre-licensure programs require that nursing students pass dosage calculation exams at a specified level of accuracy before progressing to the next term. Students typically have three tries to pass at the specified level and should they not succeed, they must withdraw. If they wish to continue in the program, they must complete the requirements for reentry which may include space availability restrictions. Factors influencing dosage calculation performance include fear of mathematics, low math self-efficacy, …


Neutrophil To Lymphocyte Ratio As A Prognostic Marker For Cardiovascular Outcomes In Patients With St-Segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention: A Systematic Review And Meta-Analysis, Hassan Ul Hussain, Kanwal Ashok Kumar, Marium Zahid, Muhammad Husban Burney, Zayeema Khan, Muqaddus Asif, Syeda Tayyaba Rehan, Huzaifa Ahmad Cheema, Sarya Swed, Farah Yasmin, Waqas Ullah, M. Chadi Alraies Jun 2024

Neutrophil To Lymphocyte Ratio As A Prognostic Marker For Cardiovascular Outcomes In Patients With St-Segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention: A Systematic Review And Meta-Analysis, Hassan Ul Hussain, Kanwal Ashok Kumar, Marium Zahid, Muhammad Husban Burney, Zayeema Khan, Muqaddus Asif, Syeda Tayyaba Rehan, Huzaifa Ahmad Cheema, Sarya Swed, Farah Yasmin, Waqas Ullah, M. Chadi Alraies

Abington Jefferson Health Papers

BACKGROUND: Neutrophil to lymphocyte ratio (NLR) has been considered a prognostic biomarker of mortality and other major cardiac events. This study investigates NLR's efficacy in predicting in-hospital and long-term outcomes in patients with ST-segment elevated myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI).

METHODS: Electronic databases (PUBMED, Cochrane CENTRAL, ERIC, Embase, Ovid, and Google Scholar) were searched till June 2022 to identify studies having STEMI patients who underwent PCI. Risk ratios and mean differences (MDs), along with their corresponding 95% confidence intervals (Cis) and standard deviations (SDs), were pooled using a random-effect model. This meta-analysis has been registered on Prospero …


Redefining Culture And Climate In The Alternative Setting: Dumping Grounds Or Where Students Are Found?, Joan Louise Barbagiovanni Jun 2024

Redefining Culture And Climate In The Alternative Setting: Dumping Grounds Or Where Students Are Found?, Joan Louise Barbagiovanni

Theses and Dissertations

This autoethnographic study aims to answer the following questions: How can a school leader design a culturally sensitive, inclusive alternative education program? What type of systemic change does an alternative school leader believe to be most effective in supporting students in attaining a high school diploma and a solid postsecondary plan to become productive members of society? What characteristics of culture and climate are most critical in an alternative school setting? The study focused on 4 years and tells how a school leader successfully changed the school culture and climate to best serve students and staff in the alternative school …


Matrix Processing With Photonic Analog Computing, James Michael Garofolo Jun 2024

Matrix Processing With Photonic Analog Computing, James Michael Garofolo

Theses and Dissertations

In the digital age, a wide variety of engineering problems have been solved, to a great deal of success, by digital computing techniques. The flexibility of software and relatively low cost of digital computing hardware make it an ideal starting point for solving a majority of tasks, and the numerical stability of software solutions make it highly appealing as the major workhorse for computational tasks. Despite this, many problems are actually suboptimally solved by digital methods, leading to systems with high latency, low throughput, power hungry parallel processing units and an excess of memory for discretizing sensor inputs. Computational photonic …


Analysis Of The Pid Controller Parameters For A Surface Mobility Platform Mobile Robot, Lwin Ma Ma Maung, Aung Myat San, Wai Mar Myint, Wut Yi Win, Min Thu Soe Jun 2024

Analysis Of The Pid Controller Parameters For A Surface Mobility Platform Mobile Robot, Lwin Ma Ma Maung, Aung Myat San, Wai Mar Myint, Wut Yi Win, Min Thu Soe

Platform: A Journal of Engineering (PAJE)

Surface mobility control is a fundamental challenge in robotics, and its applications range from autonomous vehicles to industrial automation. The main aim of the paper is to analyse the PID controller parameters for the speed control of a surface mobility platform mobile robot. MATLAB simulation toolbox and mathematical model of the DC motor are used to find the optimal PID controller parameters to complete the DC motor speed control system. For the SMP motion control system, the mobile robot kinematic model is supported as a differential drive system. In this paper, the PID controller parameters for the DC motor control …


Dynamic Modeling And Tracking Of 3-Wheels Omni-Directional Mobile Robot With Manual Pid Tuning Method, Soe Soe Htay, Khaing Win Phyu, Su Yadanar, Wut Yi Win, Min Thu Soe Jun 2024

Dynamic Modeling And Tracking Of 3-Wheels Omni-Directional Mobile Robot With Manual Pid Tuning Method, Soe Soe Htay, Khaing Win Phyu, Su Yadanar, Wut Yi Win, Min Thu Soe

Platform: A Journal of Engineering (PAJE)

This paper presents the dynamic modelling and tracking control of a holonomic 3-wheel omni-directional mobile robot. A proportional integral derivative (PID) controller is used, and its performance depends on the dynamic model’s accuracy. The controller design for the switched non-linear system is based on both a dynamic model and a kinematic design. A proposed dynamic model averages the contact radius of the 3-wheels. The resultant dynamic model, on average, is non-linear and smooth, serving as a potential solution for model-based control design. The closed-loop simulation results clearly illustrate the dynamic characteristics of the 3-wheels omni-directional mobile robot, offering valuable insights …


Repair And Surface Functionalization Of Fiber Reinforced Polymer Composites By Cold Spray, Ibnaj Anamika Anni Jun 2024

Repair And Surface Functionalization Of Fiber Reinforced Polymer Composites By Cold Spray, Ibnaj Anamika Anni

Theses and Dissertations

Fiber-reinforced polymer composites are widely used in industries and applications such as energy, automotive, defense, and aerospace. This study investigates the application of polymer cold spray, an emerging additive manufacturing process, for coating and repair of fiber-reinforced polymer (FRP) composites. The research starts with feasibility studies focused on the cold spray deposition of thermoplastic nylon-6 particles on woven glass fiber-reinforced composites (GFRP). A parametric study determines critical process parameters window, ensuring successful deposition and bonding without compromising the macroscale mechanical behavior. These findings indicate that the cold spray process does not adversely affect the fiber integrity or surface quality of …


Chemotherapy Drug Release From Hollow Core Polyethyleneimine Nanoparticles, Brian Boyle Jun 2024

Chemotherapy Drug Release From Hollow Core Polyethyleneimine Nanoparticles, Brian Boyle

Theses and Dissertations

Novel anticancer delivery vehicles are arising from engineered nanostructured materials. This work involved the synthesis, characterization, and release of novel hollow core polymeric nanoparticles (HCPNPs) for controlled drug delivery. Polyethyleneimine (PEI) was bound to AuNPs, forming polymer-shell nanoparticles with dissolution of the gold core via iodine forming HCPNPs with drug intercalated DNA bound to the surface. A high density (85 molecules/particle) of DNA intercalated with daunorubicin was conjugated. Particles were spherical with an average diameter of 105.7 ± 17.3 nm and zeta potential of 20.4 ± 3.54 mV. We hypothesize the DNA backbone electrostatically condensed to the primary amines on …


Kibra Anchoring The Action Of Pkmζ Maintains The Persistence Of Memory, Panayiotis Tsokas, Changchi Hsieh, Rafael E Flores-Obando, Matteo Bernabo, Andrew Tcherepanov, A Iván Hernández, Christian Thomas, Peter J Bergold, James E Cottrell, Joachim Kremerskothen, Harel Z Shouval, Karim Nader, André A Fenton, Todd C Sacktor Jun 2024

Kibra Anchoring The Action Of Pkmζ Maintains The Persistence Of Memory, Panayiotis Tsokas, Changchi Hsieh, Rafael E Flores-Obando, Matteo Bernabo, Andrew Tcherepanov, A Iván Hernández, Christian Thomas, Peter J Bergold, James E Cottrell, Joachim Kremerskothen, Harel Z Shouval, Karim Nader, André A Fenton, Todd C Sacktor

Faculty, Staff and Student Publications

How can short-lived molecules selectively maintain the potentiation of activated synapses to sustain long-term memory? Here, we find kidney and brain expressed adaptor protein (KIBRA), a postsynaptic scaffolding protein genetically linked to human memory performance, complexes with protein kinase Mzeta (PKMζ), anchoring the kinase's potentiating action to maintain late-phase long-term potentiation (late-LTP) at activated synapses. Two structurally distinct antagonists of KIBRA-PKMζ dimerization disrupt established late-LTP and long-term spatial memory, yet neither measurably affects basal synaptic transmission. Neither antagonist affects PKMζ-independent LTP or memory that are maintained by compensating PKCs in ζ-knockout mice; thus, both agents require PKMζ for their effect. …


Manufacturing Strategies For Optimizing Supply Chains And Mitigating Disruption, Rudolph Smith Jun 2024

Manufacturing Strategies For Optimizing Supply Chains And Mitigating Disruption, Rudolph Smith

Walden Dissertations and Doctoral Studies

Shifts in consumer demands, access to raw materials, and rapid growth can influence supply chain performance. Tool and Die (T&D) manufacturing leaders tend to be concerned with ineffective supply chains, which can harm firms’ competitiveness and profitability. Grounded in Porter’s Value Chain theory, the purpose of this qualitative pragmatic inquiry was to identify and explore strategies that some leaders in the U.S. tool and die industry use to manage supply chains successfully. The participants were five T&D manufacturing leaders in the eastern United States who successfully managed T&D supply chains. Data were collected using purposeful sampling via semistructured interviews and …