Digital Commons Network^™

Phenome-Wide Association Study Of P2rx7 Identifies Schizophrenia And Mood Disorders As Primary Associated Phenotypes, Ling Zhu, Qiao Mao, Zhixiong Luo, Bin Chen, Yong Zhang, Xiaowei Lu, Ping Liu, Jiawu Ji, Xiaoping Wang, Kesheng Wang Phd, Ma, Bs, Xinghua Pan, Yuping Cao, Na Liu, Jennifer Luo, Lingjun Zuo, Zhiren Wang, Xingguang Luo, Xiaoyun Guo

Faculty Publications

Objectives: P2RX7 has been implicated in bipolar disorder, major depressive disorder, schizophrenia, anxiety disorders, Alzheimer's disease, and Parkinson's disease. However, the specificity and comparability of these as sociations remain unclear. This study aimed to systematically evaluate multiple neuropsychiatric disorders to identify those most robustly associated with P2RX7.

Methods: We analyzed 1861 imputed SNPs spanning the P2RX7 gene in 1,087,925 individuals from 72 inde pendent cohorts across 18 neuropsychiatric disorders. SNP-disease associations were assessed within each cohort, followed by meta-analysis and false discovery rate (FDR) correction to identify significant disease-risk variants. P2RX7 mRNA and protein expression across tissues or cells …

Option Market Value-Based Reaction And Anticipation Of Corporate-Related Decisions By The United States Supreme Court., Yehuda Davis, Suresh Govindaraj, Yi Liu, Kate Suslava

Faculty Journal Articles

Our paper studies the option market reactions to judicial decisions in the United States Supreme Court (SCOTUS) relating to cases where at least one party involved is a public firm. Prior research finds the stock market is unable to anticipate SCOTUS's actions and registers a significant negative stock market reaction to the grant of certiorari (acceptance of a petition to review a lower court's decision) for respondents and, surprisingly, for petitioners as well. We show the negative price reaction for both petitioner and respondent firms is a consequence of increased uncertainty. We also provide evidence that on the day certiorari …

Seafood, Simone Lee Karlon

Intertidal

No abstract provided.

Daily Problematic Smartphone Use Predicts Decreases In Self-Control Capacity: Evidence From Random-Intercept Cross-Lagged Panel Model, Adalia Yin Hui Goh, Andree Hartanto

Research Collection School of Social Sciences

Amidst the widespread increase in global smartphone screen time and the phenomenon of ‘The Great Exhaustion’, where multiple surveys indicate pervasive tiredness and feelings of being drained, there is growing concern about the link between problematic smartphone use and the capacity for self-control. While numerous studies have investigated the relationship between problematic smartphone use and self-control capacity, they are mostly cross-sectional. Thus, it is unclear whether the lack of capacity for self-control is an antecedent or consequence of problematic smartphone use. Addressing the research gap, we conducted a 7-day diary study to investigate the bidirectional relationship between problematic smartphone use …

On-The-Fly Generation-Quality Enhancement Of Deep Code Models Via Model Collaboration, Weifeng Sun, Naiqi Huang, Meng Yan, Zhongxin Liu, Hongyan Li, Yan Lei, David Lo

Research Collection School Of Computing and Information Systems

The growing prominence of deep code models in automating software engineering tasks is undeniable. However, their deployment encounters significant challenges in on-the-fly performance enhancement, which refers to dynamically improving the performance of deep code models during real-time execution. Conventional techniques, such as retraining or fine-tuning, are effective in controlled pre-deployment scenarios but fall short when adapting to on-the-fly adjustments post-deployment. CodeDenoise, a notable on-the-fly performance enhancement technology, leverages uncertainty-based methods to identify misclassified inputs and applies an input modification strategy to rectify classification errors. While effective for classification tasks, this approach is inapplicable to generative tasks due to two key …

Sam3-Litetext: An Anatomical Study Of The Sam3 Text Encoder For Efficient Vision-Language Segmentation, Chengxi Zeng, Yuxuan Jiang, Ge Gao, Shuai Wang, Duolikun Danier, Bin Zhu, Stevan Rudinac, David Bull, Fan Zhang

Research Collection School Of Computing and Information Systems

Vision-language segmentation models such as SAM3 enable flexible, prompt-driven visual grounding, but inherit large, general-purpose text encoders originally designed for open-ended language understanding. In practice, segmentation prompts are short, structured, and semantically constrained, leading to substantial over-provisioning in text encoder capacity and persistent computational and memory overhead. In this paper, we perform a large-scale anatomical analysis of text prompting in vision–language segmentation, covering 404,796 real prompts across multiple benchmarks. Our analysis reveals severe redundancy: most context windows are underutilized, vocabulary usage is highly sparse, and text embeddings lie on a low-dimensional manifold despite high-dimensional representations. Motivated by these findings, we …

Co-Designing With Autistic Livestreamers: Care, Constraints, And Trade-Offs In Livestreaming, Terrance Mok, Anthony Tang, Lora Oehlberg

Research Collection School Of Computing and Information Systems

Autistic livestreamers use platforms like Twitch for social connection, self-expression, and community, but these spaces also impose ongoing social and emotional demands. Prior work has documented these experiences, but less is known about what autistic creators themselves envision for the tools and platforms they use. We address this gap through a Research through Design (RtD) co-design study with three autistic Twitch streamers, using speculative artefacts as discussion prompts to explore how participants reasoned about potential livestreaming technologies. Across three co-design activities, we identify three overarching tensions shaping autistic streaming practice: Expression versus Misinterpretation and Harm; Public Participation versus Control and …

“Grandpa, Can You Speak Nicer?”: Envisioned Chatbot Roles And Design Tensions In Intergenerational Communication Conflicts, Tianyi Zhang, Emran Bin Elias Poh, Yueyue Hou, Yi-Chieh Lee, Renwen Zhang, Jiannan Li, Anthony Tang

Research Collection School Of Computing and Information Systems

Intergenerational conversations often break down when differences in tone, language, or expectations lead participants to feel dismissed or misunderstood. In this work, we explore how people envision AI-driven chatbot interventions for addressing communication problems in text-based intergenerational family chat. We conducted a scenario-based design interview with 10 pairs of family members from different generations, in which participants designed chatbot interventions that varied in intervention target and timing. Our findings show that participants expect chatbots to perform multiple themes of intervention, including mediating understanding, providing emotional support, offering evaluative commentary, and guiding interaction through behavioral suggestions. These expectations varied systematically across …

The Stars Align: Modeling User Rating Calibration With Sparse Semantic Review Features, Rodrigo Alves, Antoine Ledent

Research Collection School Of Computing and Information Systems

User ratings are often treated as comparable across users, although identical scores may reflect different experiences. We study whether ratings can be viewed as user-specific discretizations of a shared semantic continuum derived from review text. Our method maps reviews into sparse semantic features with a sparse autoencoder and learns user-specific filters for each rating level. On Amazon Electronics, the learned embeddings align along a shared low-dimensional rating axis. Users differ mainly in how they anchor and partition this continuum, while preserving its overall ordinal structure. These findings support a semantic view of calibration beyond scalar bias correction.

Hide-And-Sweep: Detecting Concealed Cameras Via Led Illumination Sweeps, Jonghyuk Yun, Jaeyoung Moon, Yunseo Park, Sean Rui Xiang Tan, Byunghyun Kim, Rajesh Krishna Balan, Jun Han

Research Collection School Of Computing and Information Systems

Hidden cameras have increasingly infiltrated hotel and Airbnb rooms, posing serious privacy risks. Detecting such cameras is challenging because they are visually inconspicuous and often embedded inside everyday objects. Even worse, existing handheld detectors are manual and also rely on single-angle illumination and hence suffer from high false-positive rates. We present SweepLED (pronounced "sweepled")1, a practical hidden camera detection system that operates on a commodity smartphone augmented with an unobtrusive LED-embedded case. SweepLED performs LED sweeping - a controlled sequence of multi-angle illumination - while the user simply holds the phone still by hand, enabling the camera to capture how …

Rc-Nf: Robot-Conditioned Normalizing Flow For Real-Time Anomaly Detection In Robotic Manipulation, Shijie Zhou, Bin Zhu, Jiarui Yang, Xiangyu Zhao, Jingjing Chen, Yu-Gang Jiang

Research Collection School Of Computing and Information Systems

Recent advances in Vision-Language-Action (VLA) models have enabled robots to execute increasingly complex tasks. However, VLA models trained through imitation learning struggle to operate reliably in dynamic environments and often fail under Out-of-Distribution (OOD) conditions. To address this issue, we propose Robot-Conditioned Normalizing Flow(RC-NF), a real-time monitoring model for robotic anomaly detection and intervention that ensures the robot's state and the object's motion trajectory align with the task. RC-NF decouples the processing of task-aware robot and object states within the normalizing flow. It requires only positive samples for unsupervised training and calculates accurate robotic anomaly scores during inference through the …

Information Literacy Tutorials For High Enrollment Courses: An Iterative Design-Based Approach, Kimberly Casey, Rebekah Heleen

Communications in Information Literacy

The purpose of this paper is to provide academic librarians practical guidance on how to provide information literacy support to high enrollment, general education courses. It includes a detailed description and analysis of our approach and findings throughout the project, as well as reflections and lessons learned. The project team developed asynchronous information literacy tutorials for first-year students at the University of Arkansas, utilizing a flipped classroom approach, to address challenges in delivering personalized instruction to high-enrollment courses. Collaborating with program directors, the team created online tutorials embedded with feedback surveys, which collected nearly 2,000 student responses. We also surveyed …

Detection And Evaluation Of Hazardous Mercury Contamination In Various Biological Samples, Krish Italiya

Biochemistry and Molecular Biology

Mercury is a toxic environmental pollutant that threatens ecosystems and human health. This study investigates mercury contamination in Lactuca sativa (lettuce) and selected fish species, including tuna and salmon, focusing on plant responses and the limitations of X-ray fluorescence (XRF) analysis. In a controlled experiment, lettuce plants were exposed to mercury to evaluate uptake and toxicity, and XRF spectroscopy was used for quick, non-destructive elemental analysis. Results confirmed mercury accumulation in lettuce, along with visible stress symptoms such as leaf yellowing, purple pigmentation, and tissue damage. Mercury was not detected in tuna and salmon samples, likely due to concentrations below …

The Fellowship Of Christ's Sufferings: Toward A Practical Philosophy Of Worship For Missions In The Latin American Church, Moriah Hope Joseph

Senior Honors Theses

Within Latin America, evil and suffering are ever-present realities that cannot be concealed, and the Hispanic society is aching for relief. Liberation Theology and the prosperity gospel – and their accompanying worship practices – have been offered as tools to help alleviate the experience of suffering. But these theological perspectives and practices have accomplished little in edifying the Church by way of truth. Thus, the call for the modern missionary is to instead preach worship that is a response to the incarnate Christ in suffering. The missionary must advocate for worship practices that provide space for biblical lament, reveal a …

The Impact Of Economic Stability On Diagnostic Timing Of Autism Spectrum Disorder In Children, Leslie Box Simms

ETDs from 2020-2029

Diagnosis of neurodevelopmental delays in children, including autism spectrum disorder, is an often lengthy and burdensome process, potentially placing children with economic instability at risk for diagnostic delay. The first aim of this dissertation was to explore the impact of economic stability on diagnostic timing of autism spectrum disorder via a scoping review of the literature. Papers were summarized by study design, data sourcing, handling of variables, statistical methodology, and the effect of economic stability factors on diagnostic timing of autism. Income and healthcare insurance were the most frequently employed measures of economic stability, with transportation, housing, and food security …

Electrophysiological Retinal Changes In Aging And Its Implication In Alzheimer’S Disease, Samuel Jacob Haskins

ETDs from 2020-2029

Alzheimer’s disease remains one of the most expensive and fatal diseases facing medical practitioners to this day. According to the CDC, statistics show that it is the seventh leading cause of death worldwide. In addition to fatalities, there is a tremendous financial and emotional cost of dementia to the patient and surrounding caregivers. Improved screening techniques and new treatments for this disease are a priority of several institutes within the NIH. Early detection and early intervention are critical to improve the outcomes of patients worldwide. Amyloid beta plaques and neurofibrillary tangles (NFT) are two of the most important protein aggregates …

Comparative Evaluation Of Translucency, Fluorescence, And Structural Analysis Of 3d-Printed Vs. Conventionally Fabricated 3y, 4y And 5y Zirconia, Surabhi Chhabra

ETDs from 2020-2029

Statement of Problem: Additive manufacturing has emerged as an alternative to conventional milling for zirconia-based dental restorations because of its potential to reduce material waste and increase design flexibility. However, whether 3D-printed zirconia can provide optical and structural properties comparable with those of conventionally milled zirconia for esthetic applications remains unclear. Purpose: The purpose of this in vitro study was to compare the optical properties of 3D-printed zirconia and conventionally milled 3Y, 4Y, and 5Y zirconia, as measured by translucency and fluorescence, and to evaluate their structural characteristics, as measured by density, porosity, phase composition, and surface morphology. Materials and …

Bridging Gaps In Federally Qualified Health Centers: Examining Enabling Services And Their Role On Care Delivery, Shanequa Roscoe-Nelson

ETDs from 2020-2029

Federally Qualified Health Centers (FQHCs) are a vital provider of comprehensive healthcare for vulnerable and underserved communities. They serve populations that are disproportionately impacted by chronic health conditions and socioeconomic related barriers to healthcare. To provide adequate support and reduce barriers faced by patients, some FQHCs deliver not only primary and preventative care but also a range of enabling services. These enabling services range from providing transportation to health education and case management. This dissertation includes three studies that examine how environmental conditions are related to the use of enabling services in FQHCs, the relationship between enabling services and process …

How Did We Get Here? Mental Health Accessibility For Adults In Alabama, 1819-Present, Juliana Sea

ETDs from 2020-2029

Alabama remains one of the worst states in the nation for adult mental health access despite decades of reform and explicit commitments to improving care. Framing access as the ability to recognize need, locate services, reach them, enter care in a reasonable time, and continue or adjust care, this mixed-methods, three-paper dissertation examines how Alabama’s adult mental health system structures those pathways and how adults and providers navigate its constraints. It argues that inadequate access in Alabama contributes not only to suicide, psychiatric hospitalization, and disability, but also to shortened lifespan in the context of high burdens of chronic disease, …

Short Arc Angles-Only Initial Orbit Determination For Reliable Reacquisition Of Low Earth Orbit Objects, Isabella Rackemann

Master's Theses

Low Earth orbit (LEO) is becoming increasingly congested, furthering the need for accurate tracking and catalog maintenance. Initial orbit determination (IOD) is the first step in this process, providing a preliminary estimate of an object’s state given observations. When it comes to LEO optical observations, a large portion of them are inherently short in duration. Angles-only IOD methods struggle with this data, often producing highly inaccurate solutions that limit reacquisition capabilities. This study expands on prior short arc IOD research, testing seven classical and assumed circular orbit (ACO)-modified angles-only IOD algorithms on real LEO observational data spanning 0-4 degrees of …

Experimental Methods For Cryogenic Rare Event Detection: Cuore And Cupid, Alessandro Libenson

Physics

This senior project was written with the primary purpose of serving as a introductory guide for undergraduate students learning about the experimental methods used in the CUORE and CUPID Collaborations. In particular, this project is geared towards getting students in Dr. Gutierrez's research group at Cal Poly up to speed on what CUORE and CUPID actually do. I wrote this as an undergraduate aiming to help future undergraduates. For Cal Poly students, I would suggest the following prerequisites before reading this paper: Electronics and Instrumentation, Quantum Laboratory 1, and the equivalent of the coding/analysis class. It is also important to …

Rehabilitation Or Retribution? A Socio-Legal Comparison Of Criminal Sanctions And Social Reintegration In Indonesia And Spain, Ridwan Arifin, Izan Mateo Cassandro

The Indonesian Journal of Socio-Legal Studies

This study examines the legal, institutional, and socio-cultural mechanisms influencing the social reintegration of ex-offenders in Indonesia and Spain. Despite a global trend toward rehabilitative approaches, practical implementation reveals significant divergence due to structural, cultural, and economic factors. Indonesia’s penal system, guided by Law No. 22 of 2022 and the new Criminal Code (KUHP), emphasizes statutory rehabilitation and vocational and spiritual programs. However, challenges such as prison overcrowding, limited post-release support, and societal stigma constrain effectiveness. Judicial decisions indicate cautious application of restorative provisions, reflecting both public expectations and institutional limitations. In Spain, rehabilitation is constitutionally entrenched under Article 25(2) …

Kinetic Sculpture For The San Luis Obispo Botanical Garden, Yotam Barr, Reynaldo Farias, Natalie Krueger, Priscilla Puei Ci Lam

General Engineering

Flower Power designed, fabricated, tested, and installed a wind-driven metal lavender and bee sculpture for the San Luis Obispo Botanical Garden Children's Garden. The project provides a colorful kinetic installation that complements the existing poppy sculpture while remaining child-safe, durable outdoors, manufacturable with campus resources, and low cost to the sponsor. The final sculpture consists of a steel main stem installed in a sleeve-style concrete foundation, three green branch clusters, independently rotating purple lavender bud assemblies, decorative leaves, and a bee. The sculpture was fabricated from steel tube, sheet metal, bearings, printed ASA components, paint, and foundation materials. The installed …

Science-Related Rhetoric And Action By United States Presidents From 1977-2017, Amanda E. Shea

Interdisciplinary Studies

Presidential rhetoric and executive action have played an important role in shaping how scientific issues are presented to the American public. This project examined how United States presidents from Jimmy Carter through Barack Obama (1977–2017) employed science-related rhetoric and policy regarding climate science and reproductive health. Findings suggest that reproductive health remained a partisan issue throughout the study period, while climate science shifted from a largely bipartisan concern to a more partisan one over time. The results also indicate that presidential rhetoric and executive action were not always aligned, with several administrations using science-related rhetoric more extensively than corresponding policy.

Mars Mini Rover Sample Retrieval Robotic Claw, Cami Chambers, Ani Lachikian, Alexa Ramirez, Alex Power

Mechanical Engineering

This project involves several key stakeholders, including the Poly1 Rover Club, Professor Rich Murray, and NASA’s Jet Propulsion Laboratory (JPL). The primary objective is to develop an improved robotic claw capable of retrieving sample tubes left by the Perseverance Rover on the Martian surface. In tackling this challenge, the design must account for the harsh Mars climate while integrating cameras and electrical components, durable structure, and a rotational component to the Mini-Rover claw without incorporating an additional motor, sample storage unit, structural aspects or unnecessary weight. The current Mini-Rover consists of a four-degree-of-freedom robotic arm with joints often referred to …

Sensory, Light, And Sound Box, Galilea Andrea Portillo, Hannah Elizabeth Henderson, Marcus Kiyoshi Kanenaga

Mechanical Engineering

The Sensory, Light, and Sound Box senior project outlined an adaptable, mobile sensory environment designed to improve cognitive and visual processing skills for students with Cerebral Visual Impairment (CVI) at the Oceano Education Center. Currently, the market lacks accessible solutions tailored to these non-verbal, low-mobility students, making traditional classrooms overwhelming. This project outlines the modification of an existing static layout into a functional, three-sided wooden over-bed frame that accommodates a standard hospital bed. Our team manufactured a structurally stable verification prototype under a $500 budget, integrating slow-closing outward-hinged walls for safety, dual Bluetooth speakers, and a synchronized LED projector that …

Elevate Grill, Tanner Bachmann, Lance Anderson, Caden Huang, Jonathan Li, Brady Alexander

Mechanical Engineering

Santa Maria-style grills are a defining cooking tool of California’s Central Coast and are valued for their open fire cooking method and adjustable grate height. While this design provides direct control over cooking conditions, maintaining a consistent cooking temperature requires frequent manual adjustment of the grate position. This process relies heavily on operator experience and continuous attention, making temperature consistency difficult to maintain in a commercial kitchen environment. The Elevate Grill project was developed for Mike Ahrens and Wren Provisions to address this challenge while preserving the traditional Santa Maria grilling experience. The system uses temperature feedback from multiple thermocouples …

Toro Cover For Bob Packer, Bailey Smolinski, Brandon Petty, Arturo Ramirez, Kathryn Proctor

Mechanical Engineering

Small pools, spas, and hot tubs are common in residential homes, yet small pool owners face persistent tradeoffs between critical features such as weight, ease of use, and appearance in pool covers currently available on the market. Most products optimize a single attribute at the expense of others. For example, solar covers are energy efficient but structurally weak, safety meshes are cost-saving but intensive to install, and retractable covers are automated but expensive. Beyond these tradeoffs, existing solutions often demand multiple people to install, take time and effort, occupy valuable deck space, and sacrifice the surrounding aesthetic. Therefore, small pool …

Foldable Transfer Platform, Toby Sagi, Ashton Heiati, Triton Johnson, Zachary Denis

Mechanical Engineering

The report details the design and results of a Hoyer lift to transfer patients between wheelchairs and our sponsor's, Beacon VTC Santa Maria, vans. The lift disassembles into 3 main pieces, allowing the lift to be stored in the back of the van. The lift uses a hydraulic actuator to rotate the boom. We handed over our project to Beacon VTC Santa Maria for use in their facility!

Package Access Platform, Tyler Connor Moyers, Austin Sien, Brooke Almaraz, Aiden Montano

Mechanical Engineering

This Final Design Review (FDR) presents the completed package access platform project following fabrication, assembly, and verification testing of the final prototype. The project focused on the development of an adjustable and modular access platform capable of adapting to varying workspace requirements while maintaining operator safety and structural stability. The finalized design incorporates adjustable platform dimensions, modular frame expansion, integrated OSHA-compliant handrailing, and adjustable support legs to accommodate uneven surfaces and changing operational needs.