Digital Commons Network^™

The Impact Of Exercise On Gene Regulation In Association With Complex Trait Genetics, Nikolai G. Vetr, Nicole R. Gay, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter

Clinical Research Faculty Publications

Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes. To build this map, we integrate this multi-tissue atlas of gene expression changes with gene-disease …

Correction To: Polygenic Effects On The Risk Of Alzheimer’S Disease In The Japanese Population (Alzheimer's Research & Therapy, (2024), 16, 1, (45), 10.1186/S13195-024-01414-X), Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, Michael W. Weiner, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw

Clinical Research Faculty Publications

Following publication of the original article [1], the authors corrected an error in Fig. 2. (Figure presented.) The PRS.noAPOE and PRS.adjLD correlated with CSF Tau/Aβ42 ratios in the MCI. CSF tTau/Aβ42 (A, C) and pTau/Aβ42 (B, D) ratios by decile of PRS are shown in each diagnostic group. The participants were divided into ten groups based on the PRS.noAPOE, ranging from the lowest group (1st decile) to the highest group (10th decile). CN = cognitively normal; MCI = mild cognitive impairment; ADD = Alzheimer’s disease dementia Error: Figs. 2C and D are the same figures as Figs. 2A and B …

Sex Differences In Interacting Genetic And Functional Connectivity Biomarkers In Alzheimer’S Disease, Jordan N. Williamson, Shirley A. James, Sean P. Mullen, Bradley P. Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Balebail Ashok Raj, Kristin Fargher, Amanda Smith, Lisa Raudin, Gloria Chaing, Norman Relkin, Karen Elizabeth Smith, Hyungsub Shim, Laura L.Boles Ponto, Susan K. Schultz, Antero Sarrael, Raymundo Hernando, Nunzio Pomara, Dick Drost, Andrew Kertesz, John Rogers, Irina Rachinsky, Stephen Pasternak, Elizabether Finger, David Bachman, Kenneth Spicer, Jacobo Mintzer, Bruce L. Miller, Howard J. Rosen, Stephen Correia, Paul Malloy

Clinical Research Faculty Publications

As of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer’s disease (AD). Prior research indicates that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. Recent research shows that hippocampal functional connectivity differs by sex and may be related to the observed sex differences in AD, and apolipoprotein E (ApoE) ε4 carriers have reduced hippocampal functional connectivity. The purpose of this study was to determine if the ApoE genotype plays a role in the observed sex differences in …

Cerebrovascular Markers Of Wmh And Infarcts In Adni: A Historical Perspective And Future Directions, Pauline Maillard, Evan Fletcher, Owen Carmichael, Christopher Schwarz, Stephan Seiler, Charles Decarli

Clinical Research Faculty Publications

White matter hyperintensities (WMH) and infarcts found on magnetic resonance imaging (MR infarcts) are common biomarkers of cerebrovascular disease. In this review, we summarize the methods, publications, and conclusions stemming from the Alzheimer's Disease Neuroimaging Initiative (ADNI) related to these measures. We combine analysis of WMH and MR infarct data from across the three main ADNI cohorts with a review of existing literature discussing new methodologies and scientific findings derived from these data. Although ADNI inclusion criteria were designed to minimize vascular risk factors and disease, data across all the ADNI cohorts found consistent trends of increasing WMH volumes associated …

Blood And Mri Biomarkers Of Mild Traumatic Brain Injury In Non-Concussed Collegiate Football Players, Eunhan Cho, Joshua Granger, Bailey Theall, Nathan Lemoine, Derek Calvert, Jack Marucci, Shelly Mullenix, Hollis O’Neal, Tomas Jacome, Brian A. Irving, Neil M. Johannsen, Owen Carmichael, Guillaume Spielmann

Clinical Research Faculty Publications

Football has one of the highest incidence rates of mild traumatic brain injury (mTBI) among contact sports; however, the effects of repeated sub-concussive head impacts on brain structure and function remain under-studied. We assessed the association between biomarkers of mTBI and structural and functional MRI scans over an entire season among non-concussed NCAA Division I linemen and non-linemen. Concentrations of S100B, GFAP, BDNF, NFL, and NSE were assessed in 48 collegiate football players (32 linemen; 16 non-linemen) before the start of pre-season training (pre-camp), at the end of pre-season training (pre-season), and at the end of the competitive season (post-season). …

Evidence For A Shock-Compressed Magnetic Field In The Northwestern Rim Of Vela Jr. From X-Ray Polarimetry, Dmitry A. Prokhorov, Yi Jung Yang, Riccardo Ferrazzoli, Jacco Vink, Patrick Slane, Enrico Costa, Stefano Silvestri, Ping Zhou, Niccolò Bucciantini, Alessandro Di Marco, Martin C. Weisskopf, Luca Baldini, Victor Doroshenko, Steven R. Ehlert, Jeremy Heyl, Philip Kaaret, Dawoon E. Kim, Frédéric Marin, Tsunefumi Mizuno, Chi Yung Ng, Melissa Pesce-Rollins, Carmelo Sgrò, Paolo Soffitta, Douglas A. Swartz, Toru Tamagawa, Fei Xie, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno

Faculty Publications

Synchrotron X-ray emission has been detected from nearly a dozen young supernova remnants (SNRs). X-rays of synchrotron origin exhibit linear polarization in a regular, non-randomly oriented magnetic field. The significant polarized X-ray emission from four such SNRs has already been reported on the basis of observations with the Imaging X-ray Polarimetry Explorer (IXPE). The magnetic-field structure as derived from IXPE observations is radial for Cassiopeia A, Tycho's SNR, and SN 1006, and tangential for RX J1713.7-3946. The latter together with the recent detection of a tangential magnetic field in SNR 1E 0102.2-7219 by the Australia Telescope Compact Array in the …

Identification And Expression Analysis Of Phosphate Transporter 1 (Pht1) Genes In The Highly Phosphorus-Use-Efficient Hakea Prostrata (Proteaceae), Benjamin J. Nestor, Toby Bird, Anita A. Severn-Ellis, Philipp E. Bayer, Kosala Ranathunge, M. Asaduzzaman Prodhan, Maheshi Dassanayake, Jacqueline Batley, David Edwards, Hans Lambers, Patrick M. Finnegan

Faculty Publications

Heavy and costly use of phosphorus (P) fertiliser is often needed to achieve high crop yields, but only a small amount of applied P fertiliser is available to most crop plants. Hakea prostrata (Proteaceae) is endemic to the P-impoverished landscape of southwest Australia and has several P-saving traits. We identified 16 members of the Phosphate Transporter 1 (PHT1) gene family (HpPHT1;1-HpPHT1;12d) in a long-read genome assembly of H. prostrata. Based on phylogenetics, sequence structure and expression patterns, we classified HpPHT1;1 as potentially involved in Pi uptake from soil and HpPHT1;8 and HpPHT1;9 as potentially involved in Pi uptake and root-to-shoot …

Management Strategies For Preventing And Recovering From Bermudagrass Winterkill, W. J. Hutchens, T. Q. Carr, A. J. Patton, C. A. Bigelow, E. J. Deboer, J. M. Goatley, D. L. Martin, D. S. Mccall, G. L. Miller, J. S. Powlen, M. D. Richardson, M. Xiang

Faculty Publications

Bermudagrass (Cynodon spp. Rich) is a warm-season grass that is widely planted throughout tropical, sub-tropical, and even temperate climates, and it generally requires fewer inputs than most cool-season turfgrasses. In recent years, the area of adaptation for bermudagrass has progressively expanded to cooler climates due to the development of more cold-tolerant cultivars. The expanded area of adaptation as well as the reduced inputs required to maintain healthy turfgrass have made bermudagrass a popular choice in areas of marginal adaptation. In these areas, the greatest threat to bermudagrass health and survivability is winterkill. This management guide seeks to describe winterkill: what …

Substituent Effects On The Photophysical Properties Of A Series Of 8(Meso)-Pyridyl-Bodipys: A Computational Analysis Of The Experimental Data †, Petia Bobadova-Parvanova, Dylan Goliber, Elijuah Hernandez, Daniel Lamaster, Maria Da Graça H. Vicente

Faculty Publications

Recently, a series of 8(meso)-pyridyl-BODIPYs (2-pyridyl, 3-pyridyl, and 4-pyridyl) and their 2,6-substituted derivatives were synthesized and their structure and photophysical properties were studied both experimentally and computationally. One of the main observed trends was that the 2-pyridyl-BODIPYs were consistently less fluorescent than their 3-pyridyl and 4-pyridyl analogs, regardless of the 2,6-substituents. Herein, we extend our previous computational studies and model not only the ground but also the excited states of the entire series of previously synthesized meso-pyridyl-BODIPYs with the aim of explaining the observed differences in the emission quantum yields. To better understand the trends and the effect of 2- …

Labrad : Vol 49, Issue 2 - December 2024, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• EDITORIAL
• ARTICLES
• Anti-Glomerular Basement Membrane (GBM) Disease: Pathogenesis, Presentation, and Diagnostic Insights
• Advanced Total Laboratory Automation (TLA) Workflow: A Comprehensive Approach towards High-Throughput Analyzers in Clinical Chemistry
• Precision Under Pressure: Challenges in Therapeutic Drug Monitoring for Immunosuppressants
• Frozen Section: Diagnostic Accuracy, Pitfalls and Use of Digital Pathology
• Working Environment Perspective of a Learner
• AI Training: A Must-Have Skill for Tomorrow’s Radiologists
• Challenges in Blood Supply: Importance of Voluntary Donations
• Leadership Skills and Emotional Intelligence For Professional Capacity Building in Histopathology – A Broad Perspective
• Factor VIII and XI Deficiency; A Finding That Could Have Been Missed-A Case Report
• Accelerated Phase …

"I Can Give You Something For That": Exploring The Medical Paradigm In Mental Health Through Contemporary American Literature, Brooke Pierson

Masters Theses and Doctoral Dissertations

In this paper, I analyze two contemporary fiction novels, My Year of Rest and Relaxation by Ottessa Moshfegh and My Dark Vanessa by Kate Elizabeth Russell, through the lens of the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Moshfegh satirically critiques diagnostic psychiatry as easily exploitable, and suggests that instead of seeking asylum from pain, we should remind ourselves that happiness and pain exist in harmony; that pain is a part of life. Russell suggests the DSM-5 is imperative to understanding traumatic experiences and the mental disorders which arise from them, such as PTSD. Russell …

Radial, Vortex, And Spiral Solutions To The Nonlinear Schrödinger Equation And Other Reaction--Diffusion Systems, James Redmon Cummins

Masters Theses and Doctoral Dissertations

This dissertation explores various solutions to nonlinear reaction-diffusion systems, focusing primarily on the nonlinear Schrödinger equation. Three types of solutions are investigated: radial solutions (with no angular dependence), vortex solutions (with angular dependence but no radial phase dependence), and spiral solutions (which have radial phase dependence). The study considers free particles without potential and trapped particles inside the cylindrical potential with an impenetrable barrier. We show that spiral solutions to the nonlinear Schrödinger equation only exist for a radially constant phase by considering a related system of nonlinear ordinary differential equations. This system is shown to be a special case …

Predicting Agricultural Sciences Students’ Media Literacy In A Post-Truth Era, Abigail Durheim, Kasey Harmon, Taylor Ruth, Cara Lawson

Journal of Human Sciences and Extension

As more individuals turn to various forms of online media to seek information, misinformation and skepticism are on the rise when considering news media. Media literacy, or how individuals evaluate information they see in the news media, is critical to addressing this growing problem. This study aimed to explore the predictors of agricultural sciences students’ perceived news media literacy to gather preliminary data around this topic. Through an online survey, students enrolled in an agricultural communication class at the University of Nebraska-Lincoln completed a literacy reflection assignment. Students were asked to answer questions about their news media use, perceived media …

73 | ‘Akko Iii: The 1991–1998 Excavations: The Late Periods Part 2: The Knights’ Hotel Site, The Messika Plot And Miscellaneous Studies, Danny Syon, Ayelet Tatcher

IAA Reports—Monograph Series of the Israel Antiquities Authority

Akko III: The Late Periods comprises two parts (IAA Reports 72 and 73), the third and fourth volumes in a series publishing the results of four excavations that took place within and just outside of the Old City of ‘Akko between 1991 and 1998. These two volumes present the archaeological finds from the Early Islamic to Ottoman periods, concentrating on the architecture and small finds from the Crusader period.

The present volume (Part 2; IAA Reports 73) presents the excavations in the Knights’ Hotel Site, which yielded a wealth of small items of daily use, including glass finds, lead ampullae, …

Blinding Of Transcranial Direct Current Stimulation Is Compromised In Typically Developing Children Compared To Young Adults, Sophia Bertrand, Tonya Rich, Samuel Nemanich

Occupational Therapy Faculty Research and Publications

Achieving successful blinding is a persistent challenge for clinical trials involving transcranial direct current stimulation. Studies involving populations with increased sensory sensitivity, such as children, could be at risk for increased bias from inadequate blinding due to unique sensation of stimulation relative to adults. The objectives of this study were 1) To examine differences in transcranial stimulation blinding between children and young adults and its relationship to sensory sensitivity. 2) To test the efficacy of an ActiSham protocol for participant blinding, compared to a traditional sham protocol. Typically developing right-handed children (N = 12, 5–14 yr) and young adults (N …

Condition And Management Futures In A Quaking Aspen Recreation Area. Final Report To Snyderville Basin Special Recreation District, Paul C. Rogers, Georgie Corkery, Anna B. Miller

Aspen Bibliography

In partnership with Snyderville Basin Special Recreation District (SBSRD), we undertook a study of ecological conditions and user preferences within a quaking aspen recreational destination forest. The location, in two sections know as Run-A-Muk and Right Turn Sage (RAM/RTS), has experienced some forest die-off in the principally aspen dominated forest dissected by ski, bike, and hiking trails. Graduate student Georgie Corkery led the study and successfully completed a Master's degree, in addition to providing needed information to SBSRD regarding the status, uses, and preferred actions at this facility. Key outcomes regarding aspen conditions include assigning causal factors—ungulate browsing and elevated …

Plasma Transfusion In The Intensive Care Unit, Maite M. T. Van Haeren, Senta Jorinde Raasveld, Sanne De Bruin, Merijn C. Reuland, Claudia Van Den Oord, Jimmy Schenk, Cécile Aubron, Jan Bakker, Maurizio Cecconi, Marcus Lance

Anaesthesiology, East Africa

Background: Current guidelines discourage prophylactic plasma use in non-bleeding patients. This study assesses global plasma transfusion practices in the intensive care unit (ICU) and their alignment with current guidelines.

Study Design and Methods: This was a sub-study of an international, prospective, observational cohort. Primary outcomes were in-ICU occurrence rate of plasma transfusion, proportion of plasma events of total blood products events, and number of plasma units per event. Secondary outcomes included transfusion indications, INR/PT, and proportion of events for non-bleeding indications.

Results: Of 3643 patients included, 356 patients (10%) experienced 547 plasma transfusion events, accounting for 18% …

Informing Management Of American Shad (Alosa Sapidissima) In The Carolinas: Evaluating Novel Fish Passage Approaches And Acoustic Tracking Methods, Margaret Gaither

All Theses

Acoustic telemetry is a valuable tool for fisheries scientists to study the movements and migratory behaviors of aquatic organisms. A critical assumption of this method is that tagged fish exhibit similar behaviors and survival rates as their untagged counterparts. To investigate this, we conducted a 12-week laboratory study on adult American Shad (Alosa sapidissima) using gastroesophageal insertion of acoustic transmitters. We implanted 80 fish with dummy transmitters and monitored tag retention and survival. Our analysis, employing a mixed effects Cox’s proportional hazards model, revealed no significant differences in survival between tagged and control fish, regardless of sex. Additionally, …

An Analysis Of The Properties Of Polar Codes, Luke Szramowski

All Theses

Polar Codes have risen to the forefront of practical coding theory, due to their incredible efficiency and ease of construction. Originally introduced by Arikan in his 2009 paper, they are the first code defined with an explicit construction that achieved channel capacity. Moreover, polar codes possess some physically practical properties that make their implementation alluring. In the same paper as mentioned above, Arikan elaborated on his construction and noted that the construction given was one specific instance of a polar code and that there is a family of polar codes that can be produced by the same method. Since this …

Beauty In The Mundane, Madeline Caniglia

Theses

This project focuses on challenging what compositions are considered valuable as art. The primary focus is on the relationship between light and shadow and how it contributes to the revelation of finding beauty in the mundane. This project involves studying old masters like Caravaggio and Edward Hopper while employing their techniques and methods in my artworks. Through a series of oil paintings, I depicted everyday objects and scenes to demonstrate how classical techniques, paired with contemporary subjects, help bridge historical and artistic practices with modern art.

Anticoagulation Strategies After Left Ventricular Thrombus., Corey Uetrecht Pharmd, Jennifer Sposito Pharmd, Bcps, Bcccp, Kassandra Foellinger Pharmd, Bcps, Jamie Gaul Pharmd, Bcps, Sarah Ferrell Pharmd, Bcps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting,

This medication use evaluation found that prescribing practices of DOAC and warfarin did not change after AHA guidance publication. Patients with HFrEF were more often discharged on warfarin, while those with Afib were more often discharged on DOACs. Those discharged on a DOAC had the highest incidence of LV thrombus resolution up to 6 months post-discharge. Physicians within Parkview Health do not routinely utilize a loading dose when discharging a patient on a DOAC.

Thermal Anharmonicity Of Transition Metals: A Case Study Of Tantalum, Bimal K C

Open Access Theses & Dissertations

Density functional theory (DFT) is commonly used for evaluating the thermal propertiesand equation of state of solids, usually within the quasi-harmonic approximation (QHA). In transition metals, thermodynamic quantities such as the thermal pressure and Gruneisen parameter are poorly reproduced compared with experimental values or with direct computational methods like quantum-molecular dynamics (QMD) simulations. Surprisingly, there has not been to date, a systematic study aimed at understanding the reasons for these discrepancies. Using Tantalum as a case study, we have evaluated the temperature dependence of the phonon frequencies employing Harmonic Ensemble Lattice Dynamics (HELD) combined with classical and quantum molecular dynamics. …

Restoration Of The Cantilever Deck Structure, Calvin P. Vigeant, Roger G. Biddle, Calvin S. Morgan

Architectural Engineering

The Restoration of the Cantilever Deck Structure is an inter-disciplinary project seeking to provide public safety, the continuity of a historic structure, and contribute to the life of the Poly Canyon Experimental Structures Laboratory. This project brought together architectural engineering students Roger Biddle and Calvin Vigeant and construction management student Calvin Morgan for a year long journey of Learn by Doing. The structure is visually stunning and gives the impression of a ship cresting a wave, featuring two prominent steel masts and large tapered wood beams. The deck is perched on a steep hillside site over a seasonal creek that …

A Novel Interpretation Of Average Run Length For Assessing The Performance Of Control Charts, Gonçalo Sousa

Masters Theses

The Average Run Length (ARL) is a performance measure of Control Charts widely used within Statistical Process Control. In this study we propose a new approach for the computation of the ARL that is based on a novel interpretation of out-of-control signals produced by a Control Chart. Specifically, out-of-control signals used to calculate traditional ARLs may correspond to Type I errors and may not reflect a Control Chart’s true performance. To compensate for this issue, for Shewhart and EWMA charts, constraints are applied to the calculation of ARLs so that only out-of-control signals that occur when the corresponding statistic is …

Overdose Watch: Educate, Prevent, And Respond…Equitably, Amber Childress, Christine Nava, Genevie Porlaris

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Indisposed To Write: Teaching A Visceral Poetics, Miriam L. Atkin

The Journal of the Assembly for Expanded Perspectives on Learning

This essay begins from the premise that acts of thinking and writing are shaped immanently by corporeal need. Accordingly, my aim is to sketch a vision of composition pedagogy that acknowledges the moves and modulations of the thinking body. The route I take to get there explores four works of critical prose that mobilize form and content toward a radical re-orientation of body-in-space and body-in-writing. These texts—by Eleni Stecopoulos, Robert Kocik, William James, and Eli Clare—are to varying degrees experimental, demonstrating a manner of textual difficulty that signals the visceral difficulty implied in any act of writing. What follows is …

Contributors To Jaepl, Vol. 29, Wendy Ryden

The Journal of the Assembly for Expanded Perspectives on Learning

Contributors to JAEPL, Vol. 29

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Valor: Villains, Creatures And Foes - A Tabletop Roleplaying Game Expansion And A Methodology For Planning And Managing Tabletop Roleplaying Game Projects, Erik Ryan Ottosen

Student Projects for Graduate Degrees

Valorous Games, an independent developer and producer of Tabletop Roleplaying Games (or TTRPGs), has successfully executed three book development projects over the past seven years (the third project being a reprint and update of their first book), in addition to smaller ancillary projects. In 2023, it was determined that rescoping and restarting their third book, Valor: Villains, Creatures and Foes, would better align with future goals for the company and its proprietor. Initial research showed that little to no academic material exists for study of Project Management (or PM) in the context of the Tabletop Role-Playing Game hobby; thus, it …

How Detrimental Is Transunion V. Ramirez, Really? Understanding The Impact On Environmental Law, Lauren Young

Washington Law Review

In 2021, the United States Supreme Court issued a controversial opinion with the potential to constrict the standing doctrine. TransUnion v. Ramirez appeared to alter standing’s “concrete harm” requirement, which would significantly restrict plaintiffs’ ability to invoke the jurisdiction of federal district courts. Building off its 2016 case, Spokeo v. Robins, the Court declared that intangible harms are only concrete when “plaintiffs have identified a close historical or common-law analog[] for their asserted injury.” The “common-law analog[]” required a “close relationship to harms traditionally recognized as providing a basis for lawsuits in American courts.” The Court mandated this requirement …