Digital Commons Network^™

Serious Bacterial Infections And Hepatitis C Virus Among People Who Inject Drugs, Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean Dejace, Judith Feinberg, April M. Young, Wei Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann

Epidemiology and Environmental Health Faculty Publications

Limited research has examined the possible synergistic interrelationships between serious bacterial infections (SBIs) of the heart (i.e., endocarditis), bone, spine, brain, or joints (e.g., osteomylelitis) and hepatitis C virus (HCV) infections. We examined whether syndemic interactions existed between SBI, HCV, and substance-use-related factors in rural communities, hypothesizing that injection-mediated risks elevated the likelihood for both SBIs and HCV infections, which could be exacerbated by synergistic biological–biological or biological and social interactions. We calculated the prevalence ratios (PRs) of past-year SBI associated with each risk factor in separate models. Effect modification among significant risk factors was assessed using multiplicative interaction. Among …

Viral Transcript And Tumor Immune Microenvironment-Based Transcriptomic Profiling Of Hpv-Associated Head And Neck Squamous Cell Carcinoma Identifies Subtypes Associated With Prognosis, Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

Epidemiology and Environmental Health Faculty Publications

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. Using an AI-based analytical platform on meta cohorts, we profiled expression patterns of viral transcripts and HPV viral genome integration, and classified the tumor microenvironment (TME). Unsupervised clustering analysis revealed five distinct and novel TME subtypes across patients (immune-enriched, highly immune and B-cell enriched, fibrotic, immune-desert, and immune-enriched luminal). These TME subtypes were highly correlated with patient prognosis. In order to understand specific factors associated with prognosis, we used the unsupervised clustering of an HPV-positive HNSCC cohort from The Cancer Genome Atlas …

Document Encoding Effects On Large Language Model Response Time And Consistency, Dianeliz Ortiz Martes, Nezamoddin N. Kachouie

Mathematics and System Engineering Faculty Publications

Large language models (LLMs) such as GPT-4 are increasingly integrated into research, industry, and enterprise workflows, yet little is known about how input file formats shape their outputs. While prior work has shown that formats can influence response time, the effects on readability, complexity, and semantic stability remain underexplored. This study systematically evaluates GPT-4’s responses to 100 queries drawn from 50 academic papers, each tested across four formats, TXT, DOCX, PDF, and XML, yielding 400 question–answer pairs. We have assessed two aspects of the responses to the queries: first, efficiency quantified by response time and answer length, and second, linguistic …

Monte Carlo Gradient Boosted Trees For Cancer Staging: A Machine Learning Approach, Audrey Eley, Thu Thu Hlaing, Daniel Breininger, Zarindokht Helforoush, Nezamoddin N. Kachouie

Mathematics and System Engineering Faculty Publications

Machine learning algorithms are commonly employed for classification and interpretation of high-dimensional data. The classification task is often broken down into two separate procedures, and different methods are applied to achieve accurate results and produce interpretable outcomes. First, an effective subset of high-dimensional features must be extracted and then the selected subset will be used to train a classifier. Gradient Boosted Trees (GBT) is an ensemble model and, particularly due to their robustness, ability to model complex nonlinear interactions, and feature interpretability, they are well suited for complex applications. XGBoost (eXtreme Gradient Boosting) is a high-performance implementation of GBT that …

Education About, In, And For Wetlands: Practices, Premises, Possibilities, And Challenges, Tom Marcinkowski

Mathematics and System Engineering Faculty Publications

The purpose of this paper is to review areas of educational theory, research, and practice relevant to wetlands education, notably education about, in, and for wetlands. Five key areas are reviewed: (a) from the Report of the Intergovernmental Conference on Environmental Education, goals and objectives for wetlands education; (b) from the literature, major curricular and instructional approaches in and elements of wetlands education; (c) from the literature, broad instructional strategies available to and commonly used in wetlands education; (d) from websites of federal agencies in the U.S., education, outreach, and training programs that focus on education about, in, and for …

Ground-Based Cloud Type Classification For Aviation Weather Hazard Detection Using Deep Learning, Marcus P. Cote, Michael E. Splitt, Steven M. Lazarus, Ryan T. White, Cecilia G. Baker

Mathematics and System Engineering Faculty Publications

General aviation pilots who encounter hazardous weather face a heightened risk of fatal accidents compared to those in other sectors of aviation. To help avoid unplanned weather encounters, accurate information on cloud type and sky conditions can enhance situational awareness and hazard recognition. Among available weather information resources, ground-based webcam networks are growing for aviation meteorology and other interests such as wildfire monitoring. These webcams can provide near-real-time visual weather information to pilots, especially in regions of complex terrain where traditional weather observation methods may lack adequate spatial and temporal coverage. To harness the benefits from webcams while reducing the …

Potentiation Of Gelonin Cytotoxicity By Pulsed Electric Fields, Olga N. Pakhomova, Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, Andrei G. Pakhomov

Bioelectrics Publications

Gelonin is a ribosome-inactivating protein with extreme intracellular toxicity but poor permeation into cells. Targeted disruption of cell membranes to facilitate gelonin entry is explored for cancer and tissue ablation. We demonstrate a hundreds- to thousands-fold enhancement of gelonin cytotoxicity by pulsed electric fields in the T24, U-87, and CT26 cell lines. The effective gelonin concentration to kill 50% of cells (EC₅₀) after electroporation ranged from <1 nM to about 100 nM. For intact cells, the EC₅₀ was unattainable even at the highest gelonin concentration of 1000 nM, which reduced cell survival by only 5–15%. For isoeffective electroporation treatments using 300 ns, 9 µs, and 100 µs pulses, longer pulses were more efficient at lowering gelonin EC₅₀. Increasing the electric field strength of 8, 100 µs pulses from 0.65 to 1.25 kV/cm reduced gelonin EC₅₀ from 128 nM to 0.72 nM. Conversely, the presence of 100 nM gelonin enabled a more than 20-fold reduction in the number of pulses required for equivalent cell killing. Pulsed electric field-mediated delivery of gelonin shows promise for hyperplasia ablation at concentrations sufficiently low to minimize or avoid systemic toxicity.

Anabolic Properties Of The Progestin Altrenogest And Its Regulation As An Environmental Substance In Horse Racing – Review And Analysis, Andreas F. Lehner, Levent Dirikolu, Sarah Jacob, Kimberly Brewer, Abelardo Morales Briceñoe, Robert Holland, George Maylin, Clara Fenger, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Altrenogest is a progestogen substance used in equine medicine for the synchronization of ovulation during the spring breeding season and the control of estrus in mares. It accomplishes its actions by down-regulation of endometrial progesterone receptors and repression of estrogen receptor transcriptional activation. However, various groups have also measured androgen receptor binding activity for altrenogest in vitro; these findings combined with androgenic and anabolic properties roughly 1/20 in potency of testosterone and its structural similarity to the anabolic steroid trenbolone have created concerns among racing authorities of altrenogest’s potential abilities to alter the outcome of equine athletic performance, even though …

“That Middle School Is Trash!!!!”: Public Knowledge About Local Schools On Social Media, Ashley Carey

Education Faculty Publications

Purpose: Americans frequently turn to online social networking sites (OSNs) as a source of news and information. Yet the role of OSNs in knowledge formation about local public schools remains underexamined. This study explores how public knowledge about local schools is constructed on Facebook. Research Methods/Approach: This ethnographic case study centers on a large “private” Facebook group in the community of Oldtown (pseudonym). Drawing on digital public sphere theory, this study examines who posts about the schools on Facebook, what they post, and how interaction shapes the collective knowledge about local schools on Facebook and beyond. Findings: Posts with the …

Scope And Mechanism Of The Ruthenium-Catalyzed Sp3 C–H Coupling Reaction Of 2-Alkylindoles With Enones For The Synthesis Of Carbazole Derivatives, Krishna Prasad Gnyawali, Mina Son, Donghun Hwang, Nuwan Asanka Pannilawithana, Mu-Hyun Baik, Chase S. Yi

Chemistry Faculty Research and Publications

The catalytic system consisting of a cationic Ru–H complex 1 and 3,4,5,6-tetrachloro-1,2-benzoquinone (L1) was found to be highly effective for the dehydrative sp³ C–H coupling reaction of 2-alkyl substituted indoles with enones to form 2,4-disubstituted carbazole products. The analogous coupling reaction of 2-alkylindoles with linear enones bearing the cyclic olefinic group afforded tetracyclic carbazole products. A normal deuterium kinetic isotope effect was measured from the coupling reaction of 1,2-dimethylindole versus 1-methyl-2-(methyl-d₃)indole with (E)-3-penten-2-one (k_H/k_D = 2.5). The Hammett plot was constructed from the reaction of para-substituted …

Self-Compassion And Law Student Professional Identity Formation, Janice Craft

Law Faculty Publications

The American Bar Association’s Standards for Legal Education and Admissions to the Bar require law schools to provide students with “substantial opportunities” for “[t]he development of a professional identity.” The Standards do not require a particular curriculum or mode of instruction but offer two guideposts for legal educators: one, that “professional identity focuses on what it means to be a lawyer and the special obligations lawyers have to their clients and society,” and two, that professional formation “should involve an intentional exploration of the values, guiding principles, and well-being practices considered foundational to successful legal practice.” The guidance and concomitant …

Minor V. Happersett, Dobbs V. Jackson Women's Health Organization, And The Supreme Court's Refusal To Reconstruct America, Henry L. Chambers Jr.

Law Faculty Publications

One hundred and fifty years ago, in the wake of the ratification of the Reconstruction Amendments, the United States Supreme Court decided Minor v. Happersett. In Minor, the Court ruled Missouri could continue to deny women the right to vote based on their sex. The decision was simply reasoned. In the absence of clear constitutional text requiring Missouri to provide the right to vote to women or proof that the right to vote was a right of citizenship, Missouri had no obligation to allow women to vote. Some states had banned women citizens from voting since the country’s founding. Missouri …

Keynote: Promoting Disability Equality Behind Bars, Margo Schlanger

Articles

A few years back, I finished a five-year appointment as a “settlement monitor” in a state prison system for a civil rights case about deaf and hard-of hearing people incarcerated there. With the consent of the parties, I had been appointed by a federal court to spend time in the state’s prisons, talking to prisoners and staff, and reviewing records and facilities. I saw some obvious problems. I recall one deaf prisoner; he used American Sign Language to communicate and could not speak at all. He was found to have committed a disciplinary infraction at a proceeding where he could …

Social Media, Populism, And Militant Democracy: An Argument For A Change In First Amendment Doctrine, Arvid Kerschnitzki

Chapman Law Review

The First Amendment is often hailed as the cornerstone of American self-government, but the digital age has transformed the public discourse it was meant to protect. Social media platforms, once envisioned as a modern marketplace of ideas, now amplify misinformation, entrench echo chambers, and enable mass manipulation, threatening the democratic ideal of an informed citizenry.

While the current First Amendment doctrine rightly emphasizes the importance of public discourse, that discourse must be inclusive, rational, and reliable to serve its democratic function. Drawing on the concept of militant democracy, this Article argues that contemporary doctrine has lost sight of free speech’s …

Fingerprints Of Injustice: The Truth Behind Artificial Intelligence And Algorithmic-Driven Evidence,, Aubrey Butler

Chapman Law Review

Artificial intelligence (AI) has steadily grown in prominence, reaching into nearly every aspect of daily life, and the legal system is not immune from its influence. As various forms of machine evidence have been admitted in court, there has been an accompanying rise in concerns from researchers, judges, and defense attorneys as to the trustworthiness and reliability of this new category of evidence.

Though AI and machine evidence takes various forms, this Note focuses on some of the most prominent programs being used in courtrooms today, namely the probabilistic genotyping software TrueAllele and the recidivism rate prediction software COMPAS. The …

New York Environmental Legislation In 2024, Michael B. Gerrard

Faculty Scholarship

In 2024, New York State enacted several laws aimed either at dealing with the adverse impacts of climate change such as extreme heat and increasingl severe and frequent storms or at helping to mitigate greenhouse gas emissions to avoid or minimize the adverse impacts. The final bill signed by Governor Kathy Hochul in 2024 was the most high-profile of these laws — the Climate Change Superfund Act, which will require fossil fuel companies to pay for adaptation measures.

Other new laws last year related to extreme heat in schools and prisons, food waste, expanded polystyrene containers, community gardens, and native …

The Politics Of Bank Supervision: From Eccles To Bessent, Kathryn Judge

Faculty Scholarship

Throughout his tenure as chair of the Federal Reserve Board, Marriner Eccles pressed President Franklin D. Roosevelt to over­haul bank supervision. Eccles eventually made his ongoing service as chair contingent on FDR agreeing to support the effort. This initiative is commonly depicted as a power grab. Federal bank regulation and supervision, then and now, is divvied up among three agencies, the Federal Reserve, the Federal Deposit Insurance Corporation, and the Comptroller of the Currency. Eccles wanted the Fed, and the Fed alone, to be the federal bank supervisor. Having already succeeded in enhancing his power once, by spearheading reforms that …

Characterizing A Rad23 Dependent Ultraviolet Radiation Resistance In Tetrahymena Thermophila, Emma June Liimatta

Graduate Theses/Dissertations

In 2020, 10 million deaths were attributed to cancer, with multidrug resistance being responsible for over 90% of deaths in cancer patients receiving treatment. This study utilized the model organism Tetrahymena thermophila to study how cells become resistant to Ultraviolet Radiation (UV) radiation, a process similar to multidrug resistance, specifically focusing on the nucleotide excision repair and ubiquitin shuttle protein Rad23. The National Cancer Institute documented 30-60% of cancers tested had a mutation in RAD23. Knockdown of RAD23 in Tetrahymena thermophila demonstrated a UV resistance phenotype with decreased nucleotide excision repair and differential expression of proteins active within caspase-independent …

Providing Preschool Classrooms With Sensory Kits To Measure The Effectiveness Of Sensory Input On Motor Functioning And Sensory Integration, Elena Tedeschi

Graduate Theses/Dissertations

This study measured the effectiveness of sensory kits in preschool classrooms. Preschool children ages 2 years 9 months to 4 years old were divided into a control group classroom that did not receive sensory kits and an experimental group classroom that did receive sensory kits. Both groups were assessed in a pre-test and a post-test using 10 subsets of the Evaluation of Ayres Sensory Integration assessment to measure sensory integration and using the Peabody Developmental Motor Scale to evaluate motor progression. The control group post-test scores moved farther from norm and average scores, while the experimental group post-test scores showed …

Multiple Timescales Of Context Influence Perceptual Sensitivity To Common Pairings Of Musical Pitch And Timbre, Christian E. Stilp, Isabel Adames, Anya E. Shorey

Speech Pathology and Audiology Faculty Research and Publications

Previous studies have established that musical pitch and timbre (specifically, spectral shape) perceptually covary: lower pitches are associated with darker timbres (less higher-frequency energy) and higher pitches are associated with brighter timbres (more higher-frequency energy). In four experiments, perceptual sensitivity to this relationship was assessed in pitch labeling tasks when instrument timbre varied in ways that respected or violated this pattern (Consistent or Reversed trials). Performance was influenced by context at multiple timescales: block-level (stimulus type), experimental session-level (block order or configuration), and longer-term experience (musical training background). Across experiments, participants performed near ceiling accuracy for Consistent stimuli, but were …

Popular Originalism, Thomas G. Donnelly

Law Faculty Publications

Scholars are obsessed with the Roberts Court’s recent turn to history and tradition. But another source of authority has also emerged as an important feature of the Roberts Court’s approach to constitutional cases. In previous work, I have referred to this source of authority as popular meaning. While original meaning identifies the best reading of the Constitution’s text at the time of its ratification, popular meaning draws on sources of authority outside the courts to capture the constitutional views of the American people today. In this Article, I demonstrate how interpreters might draw on the Constitution’s popular meaning to help …

Operationalizing A Pedagogy Of Antiracism In Legal Education, Doron Samuel-Siegel

Law Faculty Publications

To reckon with structural racism in legal education, legal educators collectively must do much more than we have done thus far. A true reckoning will occur only once we provide an education that ensures racially minoritized students can learn free of the harms of traditional legal education, and that all students are equipped to contribute to the dismantlement of structural racism in the law and legal profession. A pedagogy that centers these two goals counteracts the effects of structural racism while also creating conditions for its dismantlement, making it a pedagogy of antiracism.

This article is about moving toward the …

Leading The Church Out Of White Supremacy And Toward Biblical Justice And Reconciliation: A Leadership Approach Using The Arc Model, Keenan Tyler

Doctor of Ministry Projects

Problem

Seventh-day Adventist church members need to be equipped to respond faithfully to injustice in their communities, beginning with an understanding as to how to respond to systemic racism rooted in White Supremacy.

Method

This Doctor of Ministry project implemented an adapted form of Jamar Tisby’s ARC model—Awareness, Relationships, Commitment—contextualized for a Seventh-day Adventist theological and ecclesial setting. The immediate goal was to move beyond raising awareness of racial injustice to equipping congregations to actively resist systemic racism and dismantle the lingering influence of white supremacy in church life and mission. Over six interactive sessions, 18 participants engaged in historical, …

Family Law Wordpress Blog (Vol 2. 2011-2016), Julie Shapiro, Ronald C. Slye, Annette E. Clark

Professor Julie Shapiro Legacy Project

No abstract provided.

Clinicians In The Loop Of Medical Ai, W. Nicholson Price Ii

Articles

As medical AI begins to mature as a health-care tool, the task of governance grows increasingly important. Ensuring that medical AI works, works where it’s used, and works for the patient in the moment is a challenging, multifaceted task. Some of this governance can be centralized—in review by FDA or by national accreditation labs, for instance. Some must be local, performed by the hospital or health system about to use the product in their own, unique environment. But a large amount of governance is left to the individual provider in the room, the human in the loop who presumably knows …

Should Harvard And Other Large Nonprofits Be Taxed?, Reuven S. Avi-Yonah

Articles

In this installment of Reflections With Reuven Avi-Yonah, Avi-Yonah examines justifications for exempting Harvard University and other large nonprofits from tax and argues that treating those organizations like large C corporations would not be such a bad thing. The proposal to subject large university endowment investment income to the corporate tax rate of 21 percent instead of the current 1.4 percent rate has engendered significant debate. More recently, President Trump’s threat to strip Harvard University of its tax-exempt status and treat it as a taxable corporation has likewise been controversial. In their recent Tax Notes article, Harvey Dale, Daniel Hemel, …

The Irs Approach To Periodic Adjustments: Losing Bet Or Royal Flush?, Jeffery M. Kadet, Reuven S. Avi-Yonah, David G. Chamberlain, Stephen L. Curtis

Articles

In this article, the authors argue that GLAM 2025-001 is consistent with the terms and purposes of the commensurate with income provision, relevant legislative history, and applicable case law and that the IRS approach to commensurate with income enforcement is a valid application of discretion delegated by Congress to the Treasury under Loper Bright.

Consensus And Conflict Over Context: Select Criminal Law And Procedure Cases From The Supreme Court's 2024-25 Term, Eve Brensike Primus, Elena Schultz

Articles

In its 2024-2025 Term, the Supreme Court emphasized the utility—and necessity—of context-based, fact-sensitive analyses throughout its criminal law and procedure cases. Though the Justices sparred over how to derive meaning from factual, structural, legal, and historical contexts, they tended to agree that courts should not be artificially restricted from considering the breadth of the record before them.

Periodic Adjustments And The Arm's Length Principle, Reuven S. Avi-Yonah

Articles

The Internal Revenue Service (IRS) recently issued AM 2025-001, whichrepresents a significant change in its interpretation of the periodic adjustment rules for transfers of intangibles within a multinational and forcost-sharing agreements.Arguably, this finally brings the IRS into compliancewith the “commensurate with income” language added to Code Sec. 482 in1986.

The State Capacity Crisis, David Schleicher, Nicholas Bagley

Articles

Crumbling infrastructure, inadequate housing supply, failing schools, public disorder—few government services seem to work as they should. For a decade, a nascent scholarly movement has been warning that America faces a crisis of state capacity. Although the major figures in this “state capacity movement” have identified the right problem, they concentrate almost exclusively on the federal government. That yields a misdiagnosis of why the American government lacks capacity and leads to solutions that are unlikely to accomplish much. In the United States, it is state and local governments that do most of what “the state” does, and they suffer from …